FAM84B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)5.40827277
2regulation of branching involved in prostate gland morphogenesis (GO:0060687)5.29326845
3notochord development (GO:0030903)4.39171317
4desmosome organization (GO:0002934)4.36679488
5cysteine metabolic process (GO:0006534)4.28757821
6chemical homeostasis within a tissue (GO:0048875)4.26497173
7paraxial mesoderm development (GO:0048339)4.15820314
8prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.15100540
9epithelial cell differentiation involved in prostate gland development (GO:0060742)3.85779700
10negative regulation of cell fate specification (GO:0009996)3.85167555
11branching involved in salivary gland morphogenesis (GO:0060445)3.78266974
12regulation of cardioblast differentiation (GO:0051890)3.76078313
13sulfur amino acid catabolic process (GO:0000098)3.72931918
14hepatocyte apoptotic process (GO:0097284)3.69891817
15UDP-N-acetylglucosamine metabolic process (GO:0006047)3.61421808
16planar cell polarity pathway involved in neural tube closure (GO:0090179)3.59442110
17Golgi transport vesicle coating (GO:0048200)3.57144450
18COPI coating of Golgi vesicle (GO:0048205)3.57144450
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.56912382
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.56912382
21intestinal cholesterol absorption (GO:0030299)3.52709750
22peptide catabolic process (GO:0043171)3.45805259
23apical protein localization (GO:0045176)3.45581401
24gap junction assembly (GO:0016264)3.42761761
25negative regulation of cell fate commitment (GO:0010454)3.38624360
26regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.38358630
27regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.34307481
28negative regulation of keratinocyte proliferation (GO:0010839)3.31337477
29positive regulation of catenin import into nucleus (GO:0035413)3.31072816
30intestinal absorption (GO:0050892)3.24629026
31drug catabolic process (GO:0042737)3.24293139
32maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.23147986
33asymmetric protein localization (GO:0008105)3.22334995
34ear development (GO:0043583)3.20927613
35intestinal epithelial cell development (GO:0060576)3.18297845
36transcytosis (GO:0045056)3.13320503
37hormone catabolic process (GO:0042447)3.12533524
38growth hormone receptor signaling pathway (GO:0060396)3.10993687
39exocrine pancreas development (GO:0031017)3.10043450
40epithelial cell-cell adhesion (GO:0090136)3.08119085
41homocysteine metabolic process (GO:0050667)3.08044633
42ethanol oxidation (GO:0006069)3.08028085
43sodium-independent organic anion transport (GO:0043252)3.07770017
44valine metabolic process (GO:0006573)3.07457732
45alpha-linolenic acid metabolic process (GO:0036109)3.07073401
46epithelial tube branching involved in lung morphogenesis (GO:0060441)3.05907439
47cell surface receptor signaling pathway involved in heart development (GO:0061311)3.05277196
48epithelial cell maturation (GO:0002070)2.99914737
49hippo signaling (GO:0035329)2.99478822
50regulation of cell fate specification (GO:0042659)2.98509752
51lung lobe morphogenesis (GO:0060463)2.98324254
52antigen processing and presentation of endogenous antigen (GO:0019883)2.97356660
53fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.94656095
54embryonic retina morphogenesis in camera-type eye (GO:0060059)2.90757198
55protein retention in ER lumen (GO:0006621)2.89838019
56regulation of centriole replication (GO:0046599)2.88172246
57bundle of His cell to Purkinje myocyte communication (GO:0086069)2.88016100
58regulation of cholesterol homeostasis (GO:2000188)2.87928362
59Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.86148027
60angiotensin maturation (GO:0002003)2.85873173
61lysine catabolic process (GO:0006554)2.85451562
62lysine metabolic process (GO:0006553)2.85451562
63urate metabolic process (GO:0046415)2.85267631
64cardiac right ventricle morphogenesis (GO:0003215)2.84779145
65lateral sprouting from an epithelium (GO:0060601)2.84720962
66regulation of hippo signaling (GO:0035330)2.81525488
67branching involved in mammary gland duct morphogenesis (GO:0060444)2.81516862
68branching involved in prostate gland morphogenesis (GO:0060442)2.80591518
69negative regulation of sterol transport (GO:0032372)2.79435179
70negative regulation of cholesterol transport (GO:0032375)2.79435179
71limb bud formation (GO:0060174)2.79127151
72convergent extension (GO:0060026)2.79050042
73embryonic eye morphogenesis (GO:0048048)2.78805970
74hemidesmosome assembly (GO:0031581)2.78726982
75dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.77313122
76positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.77177315
77drug transmembrane transport (GO:0006855)2.77083011
784-hydroxyproline metabolic process (GO:0019471)2.76693490
79pre-miRNA processing (GO:0031054)2.75557806
80regulation of establishment of planar polarity (GO:0090175)2.74035387
81establishment of tissue polarity (GO:0007164)2.73043250
82establishment of planar polarity (GO:0001736)2.73043250
83protein complex localization (GO:0031503)2.72622228
84establishment of apical/basal cell polarity (GO:0035089)2.71856366
85regulation of cell proliferation involved in kidney development (GO:1901722)2.69222556
86dorsal/ventral axis specification (GO:0009950)2.68821310
87regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.68235076
88amino-acid betaine metabolic process (GO:0006577)2.67747003
89regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.66101869
90ethanol metabolic process (GO:0006067)2.65650857
91face development (GO:0060324)2.63581353
92cellular response to growth hormone stimulus (GO:0071378)2.63523535
93cellular protein complex localization (GO:0034629)2.63135073
94tight junction assembly (GO:0070830)2.61366994
95non-canonical Wnt signaling pathway (GO:0035567)2.61333420
96embryonic camera-type eye morphogenesis (GO:0048596)2.61107018
97calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.60816160
98ectodermal placode formation (GO:0060788)2.60653430
99response to nitrosative stress (GO:0051409)2.59397143
100phosphate ion transmembrane transport (GO:0035435)2.59180747
101G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.58007157
102embryonic skeletal joint morphogenesis (GO:0060272)2.57371775
103reverse cholesterol transport (GO:0043691)2.57262808
104axis elongation (GO:0003401)2.55900047
105high-density lipoprotein particle remodeling (GO:0034375)2.55744208
106erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.54605229
107L-phenylalanine catabolic process (GO:0006559)2.54605229
108urea cycle (GO:0000050)2.53213331
109urea metabolic process (GO:0019627)2.53213331
110developmental induction (GO:0031128)2.53039811
111erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.52968496
112L-phenylalanine metabolic process (GO:0006558)2.52968496
113morphogenesis of an epithelial sheet (GO:0002011)2.52922219
114negative regulation of chondrocyte differentiation (GO:0032331)2.52100843
115cell-cell signaling involved in cell fate commitment (GO:0045168)2.50802467
116canonical Wnt signaling pathway (GO:0060070)2.50489227
117regulation of transforming growth factor beta2 production (GO:0032909)2.50392534
118COPII vesicle coating (GO:0048208)2.50218709
119proline biosynthetic process (GO:0006561)2.49226551
120heterochromatin organization (GO:0070828)2.49064392
121L-serine metabolic process (GO:0006563)2.48939935
122regulation of water loss via skin (GO:0033561)2.47994063
123flavonoid metabolic process (GO:0009812)2.47822906
124drug transport (GO:0015893)2.46885434
125phosphate ion transport (GO:0006817)2.45888685
126peptidyl-glutamic acid carboxylation (GO:0017187)2.45663967
127protein carboxylation (GO:0018214)2.45663967
128renal absorption (GO:0070293)2.45274756
129activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.44624399
130regulation of cholesterol biosynthetic process (GO:0045540)2.44205571
131establishment or maintenance of apical/basal cell polarity (GO:0035088)2.44161006
132establishment or maintenance of bipolar cell polarity (GO:0061245)2.44161006
133regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.43949510
134positive regulation of glycoprotein metabolic process (GO:1903020)2.43622220
135hair follicle development (GO:0001942)2.43397213
136dorsal/ventral neural tube patterning (GO:0021904)2.42866430
137embryonic foregut morphogenesis (GO:0048617)2.42474103
138maternal placenta development (GO:0001893)2.41534748
139phospholipid homeostasis (GO:0055091)2.39846479
140outflow tract septum morphogenesis (GO:0003148)2.39713104
141cellular modified amino acid catabolic process (GO:0042219)2.39075294
142regulation of endothelial cell differentiation (GO:0045601)2.38595540
143short-chain fatty acid metabolic process (GO:0046459)2.38566661
144positive regulation of endothelial cell differentiation (GO:0045603)2.38502317
145triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.38404050
146mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.38359481
147response to growth hormone (GO:0060416)2.38064257
148cell adhesion mediated by integrin (GO:0033627)2.37843433
149midgut development (GO:0007494)2.37425747
150mitotic sister chromatid cohesion (GO:0007064)2.36466009
151exogenous drug catabolic process (GO:0042738)2.36321200
152establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.36006386
153lung epithelium development (GO:0060428)2.35472519
154response to xenobiotic stimulus (GO:0009410)2.34900437
155carnitine metabolic process (GO:0009437)2.34899880
156negative regulation of fibrinolysis (GO:0051918)2.34870535
157fatty acid oxidation (GO:0019395)2.34421140
158mesenchymal cell proliferation (GO:0010463)2.34042506
159morphogenesis of an endothelium (GO:0003159)2.33826898
160endothelial tube morphogenesis (GO:0061154)2.33826898
161cholesterol transport (GO:0030301)2.33426342
162sterol transport (GO:0015918)2.33426342
163columnar/cuboidal epithelial cell development (GO:0002066)2.33386216
164protein localization to microtubule (GO:0035372)2.33179918
165regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.33024778
166positive regulation of nuclease activity (GO:0032075)2.33012605
167lipoprotein metabolic process (GO:0042157)2.33009907
168mesodermal cell differentiation (GO:0048333)2.32174066
169endoplasmic reticulum unfolded protein response (GO:0030968)2.31717961
170organ growth (GO:0035265)2.31387946
171negative regulation of lipid transport (GO:0032369)2.30982349
172xenobiotic catabolic process (GO:0042178)2.30576854
173biotin metabolic process (GO:0006768)2.30321214
174regulation of catenin import into nucleus (GO:0035412)2.29644268
175fatty acid beta-oxidation (GO:0006635)2.29537803
176apoptotic cell clearance (GO:0043277)2.29237766
177lipid oxidation (GO:0034440)2.29193875
178regulation of triglyceride catabolic process (GO:0010896)2.28475130
179lung-associated mesenchyme development (GO:0060484)2.27894301
180mammary gland alveolus development (GO:0060749)2.27270887
181regulation of keratinocyte proliferation (GO:0010837)2.26950415
182positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.25888672
183positive regulation of cell cycle G2/M phase transition (GO:1902751)2.25888672
184regulation of posttranscriptional gene silencing (GO:0060147)2.25757139
185regulation of gene silencing by miRNA (GO:0060964)2.25757139
186regulation of gene silencing by RNA (GO:0060966)2.25757139
187regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.25029202
188cell-cell junction assembly (GO:0007043)2.24889697
189nephron tubule formation (GO:0072079)2.24859076
190cell migration involved in gastrulation (GO:0042074)2.24146247
191regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.23911460
192negative regulation of striated muscle cell apoptotic process (GO:0010664)2.23906508

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.74462517
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.47934163
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.76517223
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.54800735
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.42176454
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.30931170
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.16064501
8CLOCK_20551151_ChIP-Seq_293T_Human2.75180106
9E2F7_22180533_ChIP-Seq_HELA_Human2.73315445
10GATA1_22025678_ChIP-Seq_K562_Human2.72323070
11STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.72310220
12ESR1_15608294_ChIP-ChIP_MCF-7_Human2.71943956
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.69317159
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.68307112
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.65579957
16SOX2_27498859_Chip-Seq_STOMACH_Mouse2.63607298
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.51662164
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.46104649
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.41298518
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.41298518
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.41298518
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.37680037
23ESR2_21235772_ChIP-Seq_MCF-7_Human2.35367596
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29727253
25GATA4_25053715_ChIP-Seq_YYC3_Human2.25816481
26RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20225489
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.17765895
28* SOX2_20726797_ChIP-Seq_SW620_Human2.10400497
29IRF8_22096565_ChIP-ChIP_GC-B_Human2.07709157
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06904919
31CDX2_20551321_ChIP-Seq_CACO-2_Human2.06101155
32EGR1_23403033_ChIP-Seq_LIVER_Mouse2.05858188
33* PPAR_26484153_Chip-Seq_NCI-H1993_Human2.01534883
34RBPJ_22232070_ChIP-Seq_NCS_Mouse2.00698481
35FOXO3_23340844_ChIP-Seq_DLD1_Human2.00569190
36* AHR_22903824_ChIP-Seq_MCF-7_Human1.97041561
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.97013685
38GATA6_25053715_ChIP-Seq_YYC3_Human1.96680739
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.96345458
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.94350056
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.91020763
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.90970174
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.87543344
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.83270038
45* ESR1_20079471_ChIP-ChIP_T-47D_Human1.82323809
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.78280041
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.78014618
48ZNF263_19887448_ChIP-Seq_K562_Human1.74676167
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.74448642
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.72543626
51SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.70320009
52FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.70150602
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70043453
54* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69489336
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67711788
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64936305
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.62089998
58* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.60235406
59* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.60235406
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.57128665
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53050684
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.52015047
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.51076088
64* RUNX1_27514584_Chip-Seq_MCF-7_Human1.50787214
65FOXA2_19822575_ChIP-Seq_HepG2_Human1.49214335
66ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.48089250
67SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.47757481
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.46313836
69AR_21909140_ChIP-Seq_LNCAP_Human1.46239336
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46133668
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45826917
72SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.45600646
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44961660
74SALL4_18804426_ChIP-ChIP_XEN_Mouse1.44459680
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43793694
76* ARNT_22903824_ChIP-Seq_MCF-7_Human1.43397463
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41308783
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39432936
79NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.36524991
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36522262
81CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.35126810
82* RACK7_27058665_Chip-Seq_MCF-7_Human1.34931962
83ISL1_27105846_Chip-Seq_CPCs_Mouse1.33924777
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.33834328
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33589048
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33463805
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.32831353
88* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.32213075
89* GATA3_24758297_ChIP-Seq_MCF-7_Human1.31491573
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31334498
91* ATF3_27146783_Chip-Seq_COLON_Human1.31207508
92NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30044474
93E2F1_21310950_ChIP-Seq_MCF-7_Human1.29890046
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28538262
95NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27183562
96TCF3_18692474_ChIP-Seq_MESCs_Mouse1.26245445
97* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25473786
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25430807
99SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24322560
100EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.23899402
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21968599
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21802378
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20014605
104NANOG_16153702_ChIP-ChIP_HESCs_Human1.19981332
105* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19809571
106PKCTHETA_26484144_Chip-Seq_BREAST_Human1.19158466
107* ELF5_23300383_ChIP-Seq_T47D_Human1.18787128
108HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18682742
109MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18392707
110MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18094870
111NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.17908478
112POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16818063
113ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16121410
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.14706775
115SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14483217
116HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11286684
117* CJUN_26792858_Chip-Seq_BT549_Human1.09934306
118NANOG_21062744_ChIP-ChIP_HESCs_Human1.09516363
119MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09034347
120TBX20_22080862_ChIP-Seq_HEART_Mouse1.08964903
121TBX20_22328084_ChIP-Seq_HEART_Mouse1.08964903
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07881595
123NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07363897
124FOXA1_25552417_ChIP-Seq_VCAP_Human1.07283704
125SOX2_16153702_ChIP-ChIP_HESCs_Human1.05843603
126* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05524617
127E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04736211
128ELK3_25401928_ChIP-Seq_HUVEC_Human1.04395203
129FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04204423
130KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03650644
131ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02859181
132E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02552791
133TCF7_22412390_ChIP-Seq_EML_Mouse1.02422635
134SOX17_20123909_ChIP-Seq_XEN_Mouse1.02209589
135BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01995813
136RING1B_27294783_Chip-Seq_NPCs_Mouse1.01646061
137FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01190793
138KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00939699
139STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00390860
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99901021
141POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99841508
142TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.99577906
143GATA2_19941826_ChIP-Seq_K562_Human0.97950311
144JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97418715
145KLF5_25053715_ChIP-Seq_YYC3_Human0.96864554
146HNF4A_19822575_ChIP-Seq_HepG2_Human0.96738304
147P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95975554
148IRF8_27001747_Chip-Seq_BMDM_Mouse0.95138429
149PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.94780087
150NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93556813
151SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91486234
152FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91044433
153* TP63_23658742_ChIP-Seq_EP156T_Human0.90635625
154* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90626712
155MYC_22102868_ChIP-Seq_BL_Human0.90465694
156PIAS1_25552417_ChIP-Seq_VCAP_Human0.90439745
157CHD1_26751641_Chip-Seq_LNCaP_Human0.88609817
158FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.88595091
159* UBF1/2_26484160_Chip-Seq_HMECs_Human0.83846941
160EP300_21415370_ChIP-Seq_HL-1_Mouse0.83702716
161CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83572246
162RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83344717

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.25490677
2MP0002139_abnormal_hepatobiliary_system4.07071344
3MP0005360_urolithiasis3.69402433
4MP0010030_abnormal_orbit_morphology3.19402123
5MP0003300_gastrointestinal_ulcer3.18874189
6MP0002138_abnormal_hepatobiliary_system3.13708385
7MP0005365_abnormal_bile_salt3.09724818
8MP0001666_abnormal_nutrient_absorption2.90288667
9MP0003941_abnormal_skin_development2.89371743
10MP0005085_abnormal_gallbladder_physiolo2.87792891
11MP0000579_abnormal_nail_morphology2.73574474
12MP0004782_abnormal_surfactant_physiolog2.71512308
13MP0008875_abnormal_xenobiotic_pharmacok2.70267654
14MP0004264_abnormal_extraembryonic_tissu2.56405514
15MP0003252_abnormal_bile_duct2.53786819
16MP0005083_abnormal_biliary_tract2.30365795
17MP0006054_spinal_hemorrhage2.01135136
18MP0000762_abnormal_tongue_morphology1.99428728
19MP0002697_abnormal_eye_size1.89400330
20MP0010368_abnormal_lymphatic_system1.88783771
21MP0001958_emphysema1.86416194
22MP0003937_abnormal_limbs/digits/tail_de1.84114745
23MP0005220_abnormal_exocrine_pancreas1.82727376
24MP0003890_abnormal_embryonic-extraembry1.80051504
25MP0003191_abnormal_cellular_cholesterol1.75156603
26MP0010329_abnormal_lipoprotein_level1.73585567
27MP0004019_abnormal_vitamin_homeostasis1.73482519
28MP0003705_abnormal_hypodermis_morpholog1.69414137
29MP0001873_stomach_inflammation1.69199242
30MP0001293_anophthalmia1.68850587
31MP0009643_abnormal_urine_homeostasis1.67034406
32MP0004957_abnormal_blastocyst_morpholog1.61319909
33MP0002233_abnormal_nose_morphology1.57199629
34MP0010678_abnormal_skin_adnexa1.55664587
35MP0005501_abnormal_skin_physiology1.53798417
36MP0008004_abnormal_stomach_pH1.53707638
37MP0010352_gastrointestinal_tract_polyps1.51863225
38MP0005084_abnormal_gallbladder_morpholo1.50439343
39MP0003566_abnormal_cell_adhesion1.49504641
40MP0009672_abnormal_birth_weight1.49141276
41MP0002249_abnormal_larynx_morphology1.47562026
42MP0003693_abnormal_embryo_hatching1.47186210
43MP0005332_abnormal_amino_acid1.46433677
44MP0005408_hypopigmentation1.46170415
45MP0001286_abnormal_eye_development1.44694582
46MP0000537_abnormal_urethra_morphology1.43350473
47MP0002928_abnormal_bile_duct1.41906527
48MP0006292_abnormal_olfactory_placode1.41303113
49MP0003878_abnormal_ear_physiology1.41192570
50MP0005377_hearing/vestibular/ear_phenot1.41192570
51MP0003942_abnormal_urinary_system1.40403922
52MP0000428_abnormal_craniofacial_morphol1.36469863
53MP0000467_abnormal_esophagus_morphology1.34514614
54MP0003755_abnormal_palate_morphology1.34504605
55MP0002084_abnormal_developmental_patter1.33748748
56MP0002085_abnormal_embryonic_tissue1.33081866
57MP0009840_abnormal_foam_cell1.32205940
58MP0003119_abnormal_digestive_system1.31406342
59MP0002092_abnormal_eye_morphology1.30788632
60MP0002111_abnormal_tail_morphology1.29924101
61MP0002098_abnormal_vibrissa_morphology1.28722263
62MP0000566_synostosis1.27998261
63MP0001881_abnormal_mammary_gland1.27386857
64MP0001672_abnormal_embryogenesis/_devel1.27133407
65MP0005380_embryogenesis_phenotype1.27133407
66MP0010155_abnormal_intestine_physiology1.26660998
67MP0003136_yellow_coat_color1.26583244
68MP0002234_abnormal_pharynx_morphology1.25864628
69MP0000609_abnormal_liver_physiology1.25197392
70MP0002088_abnormal_embryonic_growth/wei1.23073337
71MP0003984_embryonic_growth_retardation1.22897785
72MP0003868_abnormal_feces_composition1.21212276
73MP0002877_abnormal_melanocyte_morpholog1.21211198
74MP0008932_abnormal_embryonic_tissue1.20781871
75MP0001879_abnormal_lymphatic_vessel1.19600398
76MP0003935_abnormal_craniofacial_develop1.19514887
77MP0002136_abnormal_kidney_physiology1.18603669
78MP0005167_abnormal_blood-brain_barrier1.18501221
79MP0000647_abnormal_sebaceous_gland1.17436781
80MP0000534_abnormal_ureter_morphology1.13699984
81MP0000432_abnormal_head_morphology1.13250354
82MP0004197_abnormal_fetal_growth/weight/1.12998817
83MP0001765_abnormal_ion_homeostasis1.12618653
84MP0003453_abnormal_keratinocyte_physiol1.10584205
85MP0009764_decreased_sensitivity_to1.10146949
86MP0003123_paternal_imprinting1.10061175
87MP0009703_decreased_birth_body1.08170232
88MP0009384_cardiac_valve_regurgitation1.07806455
89MP0004233_abnormal_muscle_weight1.06961186
90MP0003936_abnormal_reproductive_system1.06833513
91MP0003077_abnormal_cell_cycle1.06274799
92MP0001697_abnormal_embryo_size1.06130156
93MP0001756_abnormal_urination1.05459828
94MP0002166_altered_tumor_susceptibility1.05241771
95MP0003315_abnormal_perineum_morphology1.05100064
96MP0003938_abnormal_ear_development1.02925965
97MP0002118_abnormal_lipid_homeostasis1.02869830
98MP0000490_abnormal_crypts_of1.02805062
99MP0001340_abnormal_eyelid_morphology1.02621405
100MP0002796_impaired_skin_barrier1.02621185
101MP0001730_embryonic_growth_arrest1.01904088
102MP0005248_abnormal_Harderian_gland1.01654767
103MP0002116_abnormal_craniofacial_bone1.01149039
104MP0005636_abnormal_mineral_homeostasis1.01026035
105MP0003861_abnormal_nervous_system1.00950401
106MP0005319_abnormal_enzyme/_coenzyme1.00720515
107MP0009780_abnormal_chondrocyte_physiolo0.98468764
108MP0000427_abnormal_hair_cycle0.97952015
109MP0005058_abnormal_lysosome_morphology0.96768821
110MP0002938_white_spotting0.96252752
111MP0000049_abnormal_middle_ear0.96114170
112MP0002086_abnormal_extraembryonic_tissu0.95671814
113MP0002254_reproductive_system_inflammat0.94892121
114MP0002089_abnormal_postnatal_growth/wei0.93398826
115MP0005187_abnormal_penis_morphology0.92467957
116MP0002282_abnormal_trachea_morphology0.92151546
117MP0000613_abnormal_salivary_gland0.91451668
118MP0003806_abnormal_nucleotide_metabolis0.90424247
119MP0004272_abnormal_basement_membrane0.89978677
120MP0001849_ear_inflammation0.89199059
121MP0004043_abnormal_pH_regulation0.88183816
122MP0003724_increased_susceptibility_to0.87782253
123MP0005499_abnormal_olfactory_system0.86849718
124MP0005394_taste/olfaction_phenotype0.86849718
125MP0000377_abnormal_hair_follicle0.85936157
126MP0004185_abnormal_adipocyte_glucose0.84000995
127MP0000465_gastrointestinal_hemorrhage0.83460438
128MP0000383_abnormal_hair_follicle0.83400524
129MP0010771_integument_phenotype0.83226744
130MP0005023_abnormal_wound_healing0.83166671
131MP0005310_abnormal_salivary_gland0.83096704
132MP0000350_abnormal_cell_proliferation0.82414161
133MP0002080_prenatal_lethality0.82296570
134MP0002295_abnormal_pulmonary_circulatio0.82126148
135MP0003385_abnormal_body_wall0.82007917
136MP0004947_skin_inflammation0.81117396
137MP0000598_abnormal_liver_morphology0.80787064
138MP0003866_abnormal_defecation0.80645593
139MP0000516_abnormal_urinary_system0.80303201
140MP0005367_renal/urinary_system_phenotyp0.80303201
141MP0003186_abnormal_redox_activity0.79903517
142MP0000477_abnormal_intestine_morphology0.79311818
143MP0001663_abnormal_digestive_system0.79134425
144MP0008789_abnormal_olfactory_epithelium0.78165477
145MP0005076_abnormal_cell_differentiation0.78002519
146MP0003111_abnormal_nucleus_morphology0.77749761
147MP0010094_abnormal_chromosome_stability0.77434192
148MP0002135_abnormal_kidney_morphology0.77134182
149MP0004133_heterotaxia0.76756486
150MP0001944_abnormal_pancreas_morphology0.75759144
151MP0000627_abnormal_mammary_gland0.75580116
152MP0001216_abnormal_epidermal_layer0.75317718
153MP0003436_decreased_susceptibility_to0.74521737
154MP0001346_abnormal_lacrimal_gland0.74410310
155MP0001664_abnormal_digestion0.73570109
156MP0003183_abnormal_peptide_metabolism0.73560553
157MP0000462_abnormal_digestive_system0.73367052
158MP0003943_abnormal_hepatobiliary_system0.73183693
159MP0001845_abnormal_inflammatory_respons0.72795526
160MP0005647_abnormal_sex_gland0.72571939
161MP0008057_abnormal_DNA_replication0.72396722
162MP0002932_abnormal_joint_morphology0.72344319
163MP0002896_abnormal_bone_mineralization0.71051690
164MP0009053_abnormal_anal_canal0.70390840
165MP0005166_decreased_susceptibility_to0.68273196
166MP0002006_tumorigenesis0.67617841
167MP0005381_digestive/alimentary_phenotyp0.65942657
168MP0003115_abnormal_respiratory_system0.64665006
169MP0003303_peritoneal_inflammation0.63422765
170MP0008469_abnormal_protein_level0.63232283
171MP0003195_calcinosis0.61800809
172MP0002060_abnormal_skin_morphology0.61534420

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)5.31361607
2Hyperactive renin-angiotensin system (HP:0000841)4.33424479
3Gout (HP:0001997)4.23641683
4Esophageal varix (HP:0002040)3.85680066
5Right ventricular cardiomyopathy (HP:0011663)3.66561265
6Deep venous thrombosis (HP:0002625)3.37783562
7Abnormality of chloride homeostasis (HP:0011422)3.23964424
8Abnormality of purine metabolism (HP:0004352)3.19876422
9Tubulointerstitial fibrosis (HP:0005576)3.17943158
10Hematochezia (HP:0002573)3.13139530
11Subacute progressive viral hepatitis (HP:0006572)3.00126749
12Onycholysis (HP:0001806)2.97335133
13Abnormality of glutamine family amino acid metabolism (HP:0010902)2.94418112
14Micronodular cirrhosis (HP:0001413)2.84104715
15Intrahepatic cholestasis (HP:0001406)2.83938742
16Vascular calcification (HP:0004934)2.82497173
17Rectal prolapse (HP:0002035)2.82164973
18Facial shape deformation (HP:0011334)2.81183781
19Potter facies (HP:0002009)2.81183781
20Glomerulosclerosis (HP:0000096)2.80056992
21Abnormality of monocarboxylic acid metabolism (HP:0010996)2.72323560
22Hyperglycinuria (HP:0003108)2.72202775
23Polycythemia (HP:0001901)2.71200376
24Concave nail (HP:0001598)2.70291081
25Abnormality of the intrinsic pathway (HP:0010989)2.70153534
26Chronic bronchitis (HP:0004469)2.65006847
27Malnutrition (HP:0004395)2.62667607
28Abnormality of the common coagulation pathway (HP:0010990)2.61789448
29Fat malabsorption (HP:0002630)2.61737994
30Partial duplication of thumb phalanx (HP:0009944)2.59919445
31Hepatocellular carcinoma (HP:0001402)2.59646286
32Aplasia involving bones of the upper limbs (HP:0009823)2.57242857
33Aplasia of the phalanges of the hand (HP:0009802)2.57242857
34Aplasia involving bones of the extremities (HP:0009825)2.57242857
35Hypoglycemic coma (HP:0001325)2.56571787
36Hyperuricemia (HP:0002149)2.55256212
37Increased purine levels (HP:0004368)2.55256212
38Septate vagina (HP:0001153)2.51057939
39Cardiovascular calcification (HP:0011915)2.50959695
40Renal salt wasting (HP:0000127)2.48320687
41Focal segmental glomerulosclerosis (HP:0000097)2.47080788
42Esophageal atresia (HP:0002032)2.45577920
43Abnormality of the distal phalanx of the thumb (HP:0009617)2.45375445
44Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.38733246
45Vertebral hypoplasia (HP:0008417)2.38733246
46Missing ribs (HP:0000921)2.38507714
47Hydroxyprolinuria (HP:0003080)2.38376584
48Abnormality of proline metabolism (HP:0010907)2.38376584
49Autoimmune thrombocytopenia (HP:0001973)2.36186565
50Aortic aneurysm (HP:0004942)2.32745132
51Vertebral clefting (HP:0008428)2.31700569
52Abnormality of the dental root (HP:0006486)2.31623979
53Taurodontia (HP:0000679)2.31623979
54Abnormality of permanent molar morphology (HP:0011071)2.31623979
55Abnormality of nucleobase metabolism (HP:0010932)2.31459847
56Selective tooth agenesis (HP:0001592)2.30897418
57Pterygium (HP:0001059)2.30892641
58Microglossia (HP:0000171)2.30404985
59High anterior hairline (HP:0009890)2.29424005
60Breast carcinoma (HP:0003002)2.29131453
61Abnormality of aromatic amino acid family metabolism (HP:0004338)2.24916088
62Abnormality of renal excretion (HP:0011036)2.21048418
63Abnormality of the nasal mucosa (HP:0000433)2.20577567
64Abnormality of the parietal bone (HP:0002696)2.20352018
65Milia (HP:0001056)2.20199800
66Tachypnea (HP:0002789)2.19910926
67Abnormality of serine family amino acid metabolism (HP:0010894)2.19597400
68Abnormality of glycine metabolism (HP:0010895)2.19597400
69Xanthomatosis (HP:0000991)2.19259791
70Pili torti (HP:0003777)2.17828204
71Ketoacidosis (HP:0001993)2.17746229
72Proximal tubulopathy (HP:0000114)2.17648651
73Dehydration (HP:0001944)2.17398025
74Sensorimotor neuropathy (HP:0007141)2.17371364
75Partial duplication of the phalanx of hand (HP:0009999)2.16606456
76Vacuolated lymphocytes (HP:0001922)2.15957222
77Flat acetabular roof (HP:0003180)2.13732310
78Asymmetry of the thorax (HP:0001555)2.12689153
79Hyperaldosteronism (HP:0000859)2.12657783
80Abdominal distention (HP:0003270)2.12639615
81Visceral angiomatosis (HP:0100761)2.12537948
82Spastic diplegia (HP:0001264)2.11843773
83Exocrine pancreatic insufficiency (HP:0001738)2.11370583
84Ketosis (HP:0001946)2.07667754
85Long toe (HP:0010511)2.06880749
86Pustule (HP:0200039)2.06077765
87Absent eyebrow (HP:0002223)2.05926129
88Hemangiomatosis (HP:0007461)2.05195122
89Curly hair (HP:0002212)2.04772596
90Spontaneous hematomas (HP:0007420)2.04652861
91Aplasia cutis congenita (HP:0001057)2.03079786
92Neonatal death (HP:0003811)2.02645862
93Germ cell neoplasia (HP:0100728)2.01977872
94Absent frontal sinuses (HP:0002688)2.01678046
95Papillary thyroid carcinoma (HP:0002895)2.00880848
96Steatorrhea (HP:0002570)1.99745353
97Fragile nails (HP:0001808)1.99668815
98Abnormality of the dental pulp (HP:0006479)1.99480884
99Abnormality of molar morphology (HP:0011070)1.99410091
100Abnormality of molar (HP:0011077)1.99410091
101Hypokalemic alkalosis (HP:0001949)1.98998520
102Arterial tortuosity (HP:0005116)1.98921697
103Menorrhagia (HP:0000132)1.98887884
104Abnormality of renin-angiotensin system (HP:0000847)1.96674450
105Urinary glycosaminoglycan excretion (HP:0003541)1.96068882
106Mucopolysacchariduria (HP:0008155)1.96068882
107Bronchomalacia (HP:0002780)1.95972845
108Cutaneous finger syndactyly (HP:0010554)1.95533418
109Absent eyelashes (HP:0000561)1.95366854
110Myocardial infarction (HP:0001658)1.93747366
111Abnormality of the lacrimal duct (HP:0011481)1.93685310
112Abnormality of sulfur amino acid metabolism (HP:0004339)1.93621357
113Hypobetalipoproteinemia (HP:0003563)1.93582402
114Hyperammonemia (HP:0001987)1.92547165
115Midline defect of the nose (HP:0004122)1.92156273
116Hyperglycinemia (HP:0002154)1.91796382
117Bicornuate uterus (HP:0000813)1.91570704
118Hypercholesterolemia (HP:0003124)1.91299650
119Respiratory distress (HP:0002098)1.91190443
120Anophthalmia (HP:0000528)1.89567926
121Abnormal biliary tract morphology (HP:0012440)1.89519788
122Abnormality of the gastric mucosa (HP:0004295)1.89446633
123Tracheal stenosis (HP:0002777)1.88743550
124Aneurysm (HP:0002617)1.87600578
125Hyperacusis (HP:0010780)1.87257662
126Maternal diabetes (HP:0009800)1.87157129
127Abnormality of the proximal phalanges of the hand (HP:0009834)1.85652474
128Impaired platelet aggregation (HP:0003540)1.85238080
129Abnormal platelet function (HP:0011869)1.85238080
130Tetany (HP:0001281)1.85066846
131Abnormality of the nasal septum (HP:0000419)1.85033994
132Bilateral microphthalmos (HP:0007633)1.84426156
133Increased nuchal translucency (HP:0010880)1.84172356
134Cutaneous syndactyly (HP:0012725)1.83750521
135Myelomeningocele (HP:0002475)1.83719812
136Joint hemorrhage (HP:0005261)1.83717858
137Abnormality of the distal phalanges of the toes (HP:0010182)1.83677092
138Abnormality of fatty-acid metabolism (HP:0004359)1.83271173
139Bifid tongue (HP:0010297)1.83047667
140Exostoses (HP:0100777)1.81953468
141Cerebral aneurysm (HP:0004944)1.81655873
142Increased mean platelet volume (HP:0011877)1.81626267
143Conjugated hyperbilirubinemia (HP:0002908)1.80927029
144Anal stenosis (HP:0002025)1.80903973
145Deviation of the thumb (HP:0009603)1.80760450
146Ileus (HP:0002595)1.80651576
147Overriding aorta (HP:0002623)1.79349968
148Abnormal vertebral ossification (HP:0100569)1.79301879
149Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79153333
150Abnormality of polysaccharide metabolism (HP:0011012)1.79153333
151Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79153333
152Biliary tract neoplasm (HP:0100574)1.78680883
153Hepatoblastoma (HP:0002884)1.78419530
154Duplication of thumb phalanx (HP:0009942)1.77239148
155Vascular tortuosity (HP:0004948)1.77045797
156Choanal stenosis (HP:0000452)1.76830077
157Abnormality of the ischium (HP:0003174)1.76443876
158Lip pit (HP:0100267)1.74672763
159Nephritis (HP:0000123)1.73976542
160Facial cleft (HP:0002006)1.73969400
161Tubulointerstitial abnormality (HP:0001969)1.73478469
162Abnormal foot bone ossification (HP:0010675)1.73382309
163Hypotrichosis (HP:0001006)1.72896594
164Bifid scrotum (HP:0000048)1.72462683
165Preaxial foot polydactyly (HP:0001841)1.72182613
166Atrophic scars (HP:0001075)1.71729635
167Septo-optic dysplasia (HP:0100842)1.70019245
168Pigmentary retinal degeneration (HP:0001146)1.68829883
169Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.68624621
170Coronal craniosynostosis (HP:0004440)1.68476025
171Abnormality of the salivary glands (HP:0010286)1.66849398
172Renal dysplasia (HP:0000110)1.64705219
173Absent radius (HP:0003974)1.64479586
174Proximal placement of thumb (HP:0009623)1.64401646
175Abnormality of the septum pellucidum (HP:0007375)1.62938038
176Abnormality of the pubic bones (HP:0003172)1.60710749
177Advanced eruption of teeth (HP:0006288)1.59547857
178Absent forearm bone (HP:0003953)1.59341231
179Aplasia involving forearm bones (HP:0009822)1.59341231
180Abnormality of the nasolacrimal system (HP:0000614)1.58535356
181Abnormality of the phalanges of the hallux (HP:0010057)1.58459278
182Ectopic anus (HP:0004397)1.57955024
183Renal hypoplasia (HP:0000089)1.57861610
184Deep philtrum (HP:0002002)1.57125906
185Abnormality of the 2nd finger (HP:0004100)1.56991803
186Hypoplastic ischia (HP:0003175)1.56909765
187Abnormal tarsal ossification (HP:0008369)1.56791641
188Mixed hearing impairment (HP:0000410)1.55603025
189Hypoplastic pelvis (HP:0008839)1.54987737
190Broad nasal tip (HP:0000455)1.54921674
191Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.54527450
192Skull defect (HP:0001362)1.53972718
193Hypoplastic labia majora (HP:0000059)1.53747680
194Neonatal short-limb short stature (HP:0008921)1.53242756
195Arnold-Chiari malformation (HP:0002308)1.53096337

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.66289146
2FRK3.30648556
3ERN13.26238053
4TAOK33.01322563
5TRIB32.92689861
6MST42.75807792
7EPHA22.60691746
8PKN22.31540816
9PTK62.19330745
10LMTK22.17766858
11MST1R2.17092870
12TGFBR22.15749317
13EEF2K2.02420037
14SIK11.83151077
15LRRK21.82082920
16TIE11.78856399
17RIPK11.73788481
18MAP3K91.71011996
19STK101.70616222
20LATS21.69442353
21BCKDK1.67597452
22STK38L1.62890448
23MAP3K31.61461081
24FGFR31.59655827
25FGFR41.57046780
26STK31.54385200
27SMG11.49483902
28MAP3K21.48074714
29PBK1.46698526
30TTK1.46372538
31FER1.46206482
32NUAK11.44578634
33EPHA31.41811384
34TSSK61.41736305
35CASK1.35901912
36PAK41.35353559
37STK391.30093338
38NEK61.28060141
39SRPK11.27878167
40ZAP701.27155402
41TRIM281.26137037
42EPHB11.25276486
43INSRR1.24227010
44WEE11.21686586
45JAK31.19339269
46BRSK21.17644387
47TAF11.16989693
48FGFR11.15832566
49KDR1.14526619
50CDK61.14219250
51IRAK31.14092663
52MKNK21.12564099
53TRPM71.12535677
54BUB11.11199808
55MAP3K121.08542192
56PTK21.08417187
57BCR1.08324280
58NEK91.06226707
59MAP2K21.03701051
60MAP3K101.03049169
61RPS6KA41.01036368
62JAK10.97037298
63RPS6KB20.96678906
64FGFR20.95384981
65MKNK10.95136882
66FLT30.94368445
67PDGFRA0.92135564
68STK240.92101108
69CDK70.88246207
70GRK10.87619978
71PNCK0.87282523
72EIF2AK10.86140950
73PASK0.84880643
74PRKG20.84835828
75VRK20.84315984
76PIK3CG0.84179321
77MET0.83934301
78HIPK20.83370331
79MAPKAPK30.81828087
80TBK10.81333818
81TTN0.78722465
82TNIK0.76086426
83MAPK150.76030581
84CHUK0.75987879
85EPHB20.75014794
86WNK40.75013854
87MAP3K140.74980017
88ICK0.74477158
89NLK0.74123406
90PDGFRB0.74084825
91CAMK1D0.74052918
92CDK120.72372305
93EIF2AK20.70702724
94SIK30.69881705
95PRKCI0.69314671
96TYK20.69207728
97ERBB40.67886674
98YES10.67649801
99MYLK0.65893244
100JAK20.65555755
101BMX0.65080185
102MAP3K80.61724129
103MAP3K70.60739657
104GSK3A0.59938987
105CSK0.59866150
106MAP2K30.59186828
107BRD40.57624793
108CDC70.56612334
109AURKB0.56236689
110BRSK10.54944441
111NME20.54882620
112PLK10.54244785
113BTK0.53663853
114MELK0.53525614
115MUSK0.53363865
116TAOK10.52735953
117PLK40.51993774
118PRKAA20.51779757
119TEC0.50987218
120AKT20.50764715
121SGK30.49508645
122DYRK30.48219924
123TGFBR10.48203248
124SCYL20.47338151
125CDK90.45647244
126RPS6KA20.45391632
127KSR10.45381918
128MATK0.45250840
129CAMK1G0.45105503
130RET0.44859540
131TESK10.44018573
132ROCK20.43934222
133AKT30.43207126
134DDR20.42975026
135CDK80.42456429
136CSNK1G10.42388614
137CHEK20.42116051
138ERBB20.41933622
139ILK0.41617080
140ITK0.41608958
141PLK30.41430801
142MTOR0.40098210
143IGF1R0.40086581
144IKBKE0.39530116
145DMPK0.38922576
146DYRK1B0.38900596
147ERBB30.38425238
148RPS6KB10.38162218
149NEK10.37659311
150PHKG10.37330919
151PHKG20.37330919
152PIK3CA0.36971757
153EGFR0.36879119
154PAK20.36842030
155NTRK10.36787557
156MAP3K10.35366934
157EPHA40.32354776

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.07668665
2Basal cell carcinoma_Homo sapiens_hsa052172.74559557
3Sulfur metabolism_Homo sapiens_hsa009202.58751828
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23794801
5Nitrogen metabolism_Homo sapiens_hsa009102.11661478
6Fatty acid degradation_Homo sapiens_hsa000712.10832719
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.03374965
8Hedgehog signaling pathway_Homo sapiens_hsa043402.03179562
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.90382899
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.89003598
11Fat digestion and absorption_Homo sapiens_hsa049751.86604364
12Tryptophan metabolism_Homo sapiens_hsa003801.81702835
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.74242439
14Caffeine metabolism_Homo sapiens_hsa002321.68682949
15Selenocompound metabolism_Homo sapiens_hsa004501.68507093
16Wnt signaling pathway_Homo sapiens_hsa043101.68206577
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67009281
18Arginine biosynthesis_Homo sapiens_hsa002201.65652870
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.60774144
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.59988953
21Histidine metabolism_Homo sapiens_hsa003401.55065761
22Propanoate metabolism_Homo sapiens_hsa006401.54124343
23Renin-angiotensin system_Homo sapiens_hsa046141.53808809
24Mineral absorption_Homo sapiens_hsa049781.52707353
25Bile secretion_Homo sapiens_hsa049761.49291246
26Chemical carcinogenesis_Homo sapiens_hsa052041.45081296
27Vitamin digestion and absorption_Homo sapiens_hsa049771.43942350
28beta-Alanine metabolism_Homo sapiens_hsa004101.43788022
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.43441370
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42352594
31PPAR signaling pathway_Homo sapiens_hsa033201.40857214
32RNA transport_Homo sapiens_hsa030131.38822665
33Adherens junction_Homo sapiens_hsa045201.37248113
34mRNA surveillance pathway_Homo sapiens_hsa030151.36403244
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36079961
36Cell cycle_Homo sapiens_hsa041101.33006798
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.30043484
38Notch signaling pathway_Homo sapiens_hsa043301.29627353
39Protein digestion and absorption_Homo sapiens_hsa049741.29621876
40Spliceosome_Homo sapiens_hsa030401.28809826
41Peroxisome_Homo sapiens_hsa041461.27724167
42Vitamin B6 metabolism_Homo sapiens_hsa007501.27592030
43Complement and coagulation cascades_Homo sapiens_hsa046101.26042336
44Steroid biosynthesis_Homo sapiens_hsa001001.25722252
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.25115215
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24652272
47Starch and sucrose metabolism_Homo sapiens_hsa005001.23819760
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.17511897
49Mismatch repair_Homo sapiens_hsa034301.17268710
50Retinol metabolism_Homo sapiens_hsa008301.17056263
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16505866
52Melanogenesis_Homo sapiens_hsa049161.16100704
53Axon guidance_Homo sapiens_hsa043601.13909809
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11553870
55ABC transporters_Homo sapiens_hsa020101.11055284
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.11011263
57Small cell lung cancer_Homo sapiens_hsa052221.09263091
58Fatty acid metabolism_Homo sapiens_hsa012121.08578906
59Ribosome_Homo sapiens_hsa030101.06357796
60DNA replication_Homo sapiens_hsa030301.05713250
61Bladder cancer_Homo sapiens_hsa052191.04468268
62ErbB signaling pathway_Homo sapiens_hsa040121.04338824
63Renal cell carcinoma_Homo sapiens_hsa052111.01185379
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00758290
65Biosynthesis of amino acids_Homo sapiens_hsa012301.00366718
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99406994
67Glutathione metabolism_Homo sapiens_hsa004800.98726072
68p53 signaling pathway_Homo sapiens_hsa041150.97336597
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.96072718
70Basal transcription factors_Homo sapiens_hsa030220.95468878
71Melanoma_Homo sapiens_hsa052180.92030015
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90220983
73Nucleotide excision repair_Homo sapiens_hsa034200.89656541
74Lysine degradation_Homo sapiens_hsa003100.88172334
75AMPK signaling pathway_Homo sapiens_hsa041520.88000793
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87698848
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87678680
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87499095
79Colorectal cancer_Homo sapiens_hsa052100.86739534
80Pancreatic cancer_Homo sapiens_hsa052120.86550234
81Other glycan degradation_Homo sapiens_hsa005110.85821473
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84179230
83Glycerolipid metabolism_Homo sapiens_hsa005610.83577857
84Insulin resistance_Homo sapiens_hsa049310.83067899
85Pancreatic secretion_Homo sapiens_hsa049720.81414635
86Pathways in cancer_Homo sapiens_hsa052000.81147194
87Base excision repair_Homo sapiens_hsa034100.80019323
88Folate biosynthesis_Homo sapiens_hsa007900.79908094
89Butanoate metabolism_Homo sapiens_hsa006500.79645306
90Arginine and proline metabolism_Homo sapiens_hsa003300.79562934
91Toxoplasmosis_Homo sapiens_hsa051450.79529492
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78551476
93Tight junction_Homo sapiens_hsa045300.77077174
94ECM-receptor interaction_Homo sapiens_hsa045120.76564586
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75684315
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75376846
97Non-homologous end-joining_Homo sapiens_hsa034500.75321396
98Chronic myeloid leukemia_Homo sapiens_hsa052200.74563369
99Hepatitis C_Homo sapiens_hsa051600.74547209
100Fatty acid biosynthesis_Homo sapiens_hsa000610.73871706
101Pyruvate metabolism_Homo sapiens_hsa006200.73548832
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73311434
103Thyroid cancer_Homo sapiens_hsa052160.72827788
104Insulin signaling pathway_Homo sapiens_hsa049100.70303116
105N-Glycan biosynthesis_Homo sapiens_hsa005100.70228219
106Lysosome_Homo sapiens_hsa041420.69241321
107Phenylalanine metabolism_Homo sapiens_hsa003600.68912917
108Fanconi anemia pathway_Homo sapiens_hsa034600.68604687
109TNF signaling pathway_Homo sapiens_hsa046680.67650650
110Focal adhesion_Homo sapiens_hsa045100.67401088
111Inositol phosphate metabolism_Homo sapiens_hsa005620.67098642
112Staphylococcus aureus infection_Homo sapiens_hsa051500.64645925
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63748599
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.63654637
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63367939
116RNA degradation_Homo sapiens_hsa030180.61652641
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61620866
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.60521201
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60000349
120Endometrial cancer_Homo sapiens_hsa052130.59551189
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58249482
122Sphingolipid metabolism_Homo sapiens_hsa006000.57156814
123Proteoglycans in cancer_Homo sapiens_hsa052050.57083964
124One carbon pool by folate_Homo sapiens_hsa006700.57063359
125Thyroid hormone synthesis_Homo sapiens_hsa049180.56629317
126Carbon metabolism_Homo sapiens_hsa012000.56242360
127Prolactin signaling pathway_Homo sapiens_hsa049170.55827952
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54163098
129Dilated cardiomyopathy_Homo sapiens_hsa054140.53726126
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53525979
131Proteasome_Homo sapiens_hsa030500.53475350
132Amoebiasis_Homo sapiens_hsa051460.53320458
133Galactose metabolism_Homo sapiens_hsa000520.52973364
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52965046
1352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52833114
136Prostate cancer_Homo sapiens_hsa052150.52456435
137Fatty acid elongation_Homo sapiens_hsa000620.52391959
138Pentose phosphate pathway_Homo sapiens_hsa000300.51883920
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.51520524
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51447184
141Circadian rhythm_Homo sapiens_hsa047100.51236263
142Choline metabolism in cancer_Homo sapiens_hsa052310.50955199
143Hippo signaling pathway_Homo sapiens_hsa043900.50811229
144Glioma_Homo sapiens_hsa052140.50740708
145Glucagon signaling pathway_Homo sapiens_hsa049220.50102068
146Non-small cell lung cancer_Homo sapiens_hsa052230.50094042
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.47139999
148Influenza A_Homo sapiens_hsa051640.46757981
149Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46312249
150Estrogen signaling pathway_Homo sapiens_hsa049150.46201467
151Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45661695
152MicroRNAs in cancer_Homo sapiens_hsa052060.43982655
153Tyrosine metabolism_Homo sapiens_hsa003500.43280021
154Apoptosis_Homo sapiens_hsa042100.43147159
155TGF-beta signaling pathway_Homo sapiens_hsa043500.40772028
156Cysteine and methionine metabolism_Homo sapiens_hsa002700.40433227
157Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38766044

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