ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.75127228
2	axon extension involved in axon guidance (GO:0048846)	5.46823914
3	neuron projection extension involved in neuron projection guidance (GO:1902284)	5.46823914
4	ganglion development (GO:0061548)	4.87082423
5	axonemal dynein complex assembly (GO:0070286)	4.70115001
6	motile cilium assembly (GO:0044458)	4.66089332
7	epithelial cilium movement (GO:0003351)	4.53681739
8	cilium or flagellum-dependent cell motility (GO:0001539)	4.47728422
9	cilium movement (GO:0003341)	4.40897322
10	protein neddylation (GO:0045116)	4.38681432
11	regulation of cilium movement (GO:0003352)	4.25915513
12	negative regulation of axon guidance (GO:1902668)	4.19688875
13	negative regulation of axon extension involved in axon guidance (GO:0048843)	4.09583444
14	arginine catabolic process (GO:0006527)	3.84091794
15	axoneme assembly (GO:0035082)	3.76414921
16	intraciliary transport (GO:0042073)	3.72991437
17	microtubule depolymerization (GO:0007019)	3.68729615
18	nonmotile primary cilium assembly (GO:0035058)	3.55728809
19	DNA damage response, detection of DNA damage (GO:0042769)	3.53218664
20	cilium morphogenesis (GO:0060271)	3.45122817
21	cell proliferation in forebrain (GO:0021846)	3.36019432
22	facial nerve structural organization (GO:0021612)	3.32425709
23	retinal rod cell development (GO:0046548)	3.26218608
24	L-serine metabolic process (GO:0006563)	3.08654608
25	peptidyl-histidine modification (GO:0018202)	3.03414542
26	tongue development (GO:0043586)	2.98903123
27	water-soluble vitamin biosynthetic process (GO:0042364)	2.90183385
28	cilium organization (GO:0044782)	2.88886509
29	brain morphogenesis (GO:0048854)	2.88054537
30	cilium assembly (GO:0042384)	2.86143496
31	regulation of microtubule-based movement (GO:0060632)	2.84607854
32	radial glial cell differentiation (GO:0060019)	2.74760343
33	DNA double-strand break processing (GO:0000729)	2.72138199
34	photoreceptor cell maintenance (GO:0045494)	2.68319223
35	forebrain morphogenesis (GO:0048853)	2.63018329
36	left/right pattern formation (GO:0060972)	2.62584721
37	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.62113836
38	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.62113836
39	microtubule polymerization or depolymerization (GO:0031109)	2.61224514
40	meiotic chromosome segregation (GO:0045132)	2.59795933
41	GTP biosynthetic process (GO:0006183)	2.56363319
42	cranial nerve structural organization (GO:0021604)	2.55618693
43	anterograde synaptic vesicle transport (GO:0048490)	2.54600250
44	serine family amino acid catabolic process (GO:0009071)	2.52981357
45	left/right axis specification (GO:0070986)	2.50066412
46	smoothened signaling pathway (GO:0007224)	2.48860853
47	microtubule bundle formation (GO:0001578)	2.47098990
48	growth hormone secretion (GO:0030252)	2.45119811
49	postsynaptic membrane organization (GO:0001941)	2.44616799
50	protein localization to cilium (GO:0061512)	2.42186798
51	DNA strand renaturation (GO:0000733)	2.40973659
52	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.40580485
53	melanosome transport (GO:0032402)	2.38169380
54	alanine transport (GO:0032328)	2.38153649
55	UTP biosynthetic process (GO:0006228)	2.38102444
56	regulation of axon guidance (GO:1902667)	2.37777957
57	DNA replication-dependent nucleosome organization (GO:0034723)	2.37765214
58	DNA replication-dependent nucleosome assembly (GO:0006335)	2.37765214
59	proline transport (GO:0015824)	2.37375880
60	presynaptic membrane assembly (GO:0097105)	2.34708127
61	regulation of respiratory system process (GO:0044065)	2.34390807
62	synaptic transmission, glutamatergic (GO:0035249)	2.33411065
63	establishment of melanosome localization (GO:0032401)	2.33134402
64	tRNA processing (GO:0008033)	2.31954625
65	citrulline metabolic process (GO:0000052)	2.31906628
66	mRNA splice site selection (GO:0006376)	2.31454590
67	convergent extension (GO:0060026)	2.31305461
68	negative regulation of smoothened signaling pathway (GO:0045879)	2.30713605
69	protein complex biogenesis (GO:0070271)	2.30679281
70	chromatin remodeling at centromere (GO:0031055)	2.30458358
71	CTP metabolic process (GO:0046036)	2.30339411
72	CTP biosynthetic process (GO:0006241)	2.30339411
73	pseudouridine synthesis (GO:0001522)	2.27715447
74	L-serine transport (GO:0015825)	2.27474758
75	serine family amino acid biosynthetic process (GO:0009070)	2.26948207
76	melanosome localization (GO:0032400)	2.26874320
77	glycine metabolic process (GO:0006544)	2.25656764
78	tRNA metabolic process (GO:0006399)	2.25304870
79	mitochondrial respiratory chain complex assembly (GO:0033108)	2.24808161
80	regulation of posttranscriptional gene silencing (GO:0060147)	2.24719851
81	regulation of gene silencing by miRNA (GO:0060964)	2.24719851
82	regulation of gene silencing by RNA (GO:0060966)	2.24719851
83	pigment granule transport (GO:0051904)	2.24435101
84	spinal cord motor neuron differentiation (GO:0021522)	2.23858331
85	photoreceptor cell development (GO:0042461)	2.23425540
86	protein targeting to mitochondrion (GO:0006626)	2.22347677
87	centriole assembly (GO:0098534)	2.21970678
88	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.21858451
89	embryonic body morphogenesis (GO:0010172)	2.21822923
90	non-recombinational repair (GO:0000726)	2.21588607
91	double-strand break repair via nonhomologous end joining (GO:0006303)	2.21588607
92	NADH dehydrogenase complex assembly (GO:0010257)	2.21586372
93	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.21586372
94	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.21586372
95	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.21563002
96	establishment of pigment granule localization (GO:0051905)	2.20216177
97	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.20036205
98	inner mitochondrial membrane organization (GO:0007007)	2.19921272
99	cerebral cortex neuron differentiation (GO:0021895)	2.19236933
100	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.18596774

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.16625181
2	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.62294353
3	VDR_22108803_ChIP-Seq_LS180_Human	3.02984067
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.72542366
5	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.64011092
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.50934239
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.42507587
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.38854727
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.38623335
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.33049267
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.26828296
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.25348784
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.18564430
14	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.14736625
15	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.12999113
16	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.98906839
17	* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.96842229
18	GABP_19822575_ChIP-Seq_HepG2_Human	1.89126044
19	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.88606758
20	MYC_18940864_ChIP-ChIP_HL60_Human	1.87731058
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.78988717
22	XRN2_22483619_ChIP-Seq_HELA_Human	1.74005926
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.70611933
24	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.63428192
25	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.62670380
26	VDR_23849224_ChIP-Seq_CD4+_Human	1.61032373
27	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.57279978
28	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.56818704
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.55801009
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.52112012
31	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.49669242
32	EWS_26573619_Chip-Seq_HEK293_Human	1.48781964
33	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.46185544
34	TTF2_22483619_ChIP-Seq_HELA_Human	1.43647384
35	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.42858377
36	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.39391427
37	FOXP3_21729870_ChIP-Seq_TREG_Human	1.30869187
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30326068
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.29955273
40	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.29828120
41	FUS_26573619_Chip-Seq_HEK293_Human	1.29573218
42	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.28189260
43	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.27098128
44	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.26064900
45	RNF2_27304074_Chip-Seq_NSC_Mouse	1.23490252
46	ELK1_19687146_ChIP-ChIP_HELA_Human	1.22299085
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20803524
48	* WDR5_24793694_ChIP-Seq_LNCAP_Human	1.20074596
49	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.19449306
50	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.19397882
51	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.17843095
52	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17614673
53	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.15539502
54	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.14714952
55	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.14253696
56	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.14051766
57	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.13584874
58	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.13179140
59	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.12725551
60	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.12597084
61	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.11931493
62	* FOXP1_21924763_ChIP-Seq_HESCs_Human	1.11778770
63	KDM5A_27292631_Chip-Seq_BREAST_Human	1.10802267
64	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.10636164
65	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.10097759
66	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.08315616
67	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.07321821
68	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.07092149
69	GBX2_23144817_ChIP-Seq_PC3_Human	1.07013919
70	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.06537415
71	PHF8_20622854_ChIP-Seq_HELA_Human	1.05951710
72	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.04745498
73	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.04230596
74	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.03754390
75	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.00451957
76	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.99488667
77	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.97668915
78	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.94768617
79	TAF15_26573619_Chip-Seq_HEK293_Human	0.92290841
80	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.92052159
81	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.91569265
82	CTCF_27219007_Chip-Seq_Bcells_Human	0.91250493
83	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.89200851
84	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.88886445
85	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.87679871
86	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.87632892
87	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.87534225
88	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.87094514
89	* PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.87086168
90	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.86209956
91	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.86123213
92	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.85854194
93	ERA_21632823_ChIP-Seq_H3396_Human	0.85384856
94	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.84004511
95	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.83786015
96	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.83173892
97	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.82994931
98	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.81684005
99	E2F1_20622854_ChIP-Seq_HELA_Human	0.80666920
100	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.80506259

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.16375518
2	MP0000566_synostosis	3.43118448
3	MP0008789_abnormal_olfactory_epithelium	3.29484937
4	MP0005499_abnormal_olfactory_system	3.02914334
5	MP0005394_taste/olfaction_phenotype	3.02914334
6	MP0010030_abnormal_orbit_morphology	2.90341670
7	MP0003136_yellow_coat_color	2.90304091
8	MP0002938_white_spotting	2.83643013
9	MP0001984_abnormal_olfaction	2.54321730
10	MP0001986_abnormal_taste_sensitivity	2.40721054
11	MP0001293_anophthalmia	2.27160886
12	MP0001968_abnormal_touch/_nociception	2.17472469
13	MP0002653_abnormal_ependyma_morphology	2.04821884
14	MP0000778_abnormal_nervous_system	2.02762134
15	MP0002736_abnormal_nociception_after	1.83888998
16	MP0005248_abnormal_Harderian_gland	1.66058155
17	MP0005423_abnormal_somatic_nervous	1.65916246
18	MP0003122_maternal_imprinting	1.64467685
19	MP0004133_heterotaxia	1.60967056
20	MP0001188_hyperpigmentation	1.56156331
21	MP0004859_abnormal_synaptic_plasticity	1.54187580
22	MP0008058_abnormal_DNA_repair	1.51492341
23	MP0002735_abnormal_chemical_nociception	1.50776386
24	MP0000631_abnormal_neuroendocrine_gland	1.49014762
25	MP0003121_genomic_imprinting	1.48785086
26	MP0000049_abnormal_middle_ear	1.47398169
27	MP0001529_abnormal_vocalization	1.42410650
28	MP0002233_abnormal_nose_morphology	1.39197285
29	MP0005174_abnormal_tail_pigmentation	1.32493370
30	MP0003937_abnormal_limbs/digits/tail_de	1.30647114
31	MP0002249_abnormal_larynx_morphology	1.30462044
32	MP0003123_paternal_imprinting	1.26979323
33	MP0002734_abnormal_mechanical_nocicepti	1.26402891
34	MP0005551_abnormal_eye_electrophysiolog	1.24598215
35	MP0002184_abnormal_innervation	1.21988479
36	MP0002572_abnormal_emotion/affect_behav	1.21930504
37	MP0002557_abnormal_social/conspecific_i	1.18491744
38	MP0005084_abnormal_gallbladder_morpholo	1.18316291
39	MP0003635_abnormal_synaptic_transmissio	1.17569421
40	MP0003880_abnormal_central_pattern	1.16561944
41	MP0002063_abnormal_learning/memory/cond	1.13444534
42	MP0010094_abnormal_chromosome_stability	1.13146227
43	MP0006276_abnormal_autonomic_nervous	1.12060699
44	MP0003693_abnormal_embryo_hatching	1.11032221
45	MP0005253_abnormal_eye_physiology	1.09919804
46	MP0003119_abnormal_digestive_system	1.09233492
47	MP0000579_abnormal_nail_morphology	1.09131736
48	MP0005391_vision/eye_phenotype	1.08775257
49	MP0009053_abnormal_anal_canal	1.08660332
50	MP0006072_abnormal_retinal_apoptosis	1.08166060
51	MP0008877_abnormal_DNA_methylation	1.06935472
52	MP0009745_abnormal_behavioral_response	1.06324897
53	MP0003861_abnormal_nervous_system	1.05295435
54	MP0009046_muscle_twitch	1.04699344
55	MP0000026_abnormal_inner_ear	1.03467745
56	MP0008932_abnormal_embryonic_tissue	1.02132139
57	MP0002092_abnormal_eye_morphology	0.97942341
58	MP0001502_abnormal_circadian_rhythm	0.97763180
59	MP0005083_abnormal_biliary_tract	0.96887768
60	MP0003938_abnormal_ear_development	0.96627908
61	MP0001485_abnormal_pinna_reflex	0.95672658
62	MP0003787_abnormal_imprinting	0.95351621
63	MP0005646_abnormal_pituitary_gland	0.94831926
64	MP0003755_abnormal_palate_morphology	0.93276261
65	MP0001849_ear_inflammation	0.92884019
66	MP0002752_abnormal_somatic_nervous	0.92439932
67	MP0003718_maternal_effect	0.91189530
68	MP0002152_abnormal_brain_morphology	0.89783059
69	MP0001286_abnormal_eye_development	0.89018083
70	MP0002272_abnormal_nervous_system	0.88712911
71	MP0001486_abnormal_startle_reflex	0.87875072
72	MP0001963_abnormal_hearing_physiology	0.87026390
73	MP0005377_hearing/vestibular/ear_phenot	0.86540986
74	MP0003878_abnormal_ear_physiology	0.86540986
75	MP0001970_abnormal_pain_threshold	0.85200978
76	MP0004957_abnormal_blastocyst_morpholog	0.84698734
77	MP0003942_abnormal_urinary_system	0.84612211
78	MP0002234_abnormal_pharynx_morphology	0.84310045
79	MP0008995_early_reproductive_senescence	0.83123702
80	MP0002160_abnormal_reproductive_system	0.82952034
81	MP0000955_abnormal_spinal_cord	0.82557311
82	MP0003698_abnormal_male_reproductive	0.82215840
83	MP0002102_abnormal_ear_morphology	0.81404905
84	MP0002064_seizures	0.81026239
85	MP0002882_abnormal_neuron_morphology	0.79872760
86	MP0004147_increased_porphyrin_level	0.79207205
87	MP0002116_abnormal_craniofacial_bone	0.77522495
88	MP0008875_abnormal_xenobiotic_pharmacok	0.77431176
89	MP0003890_abnormal_embryonic-extraembry	0.77179340
90	MP0005171_absent_coat_pigmentation	0.76994486
91	MP0005195_abnormal_posterior_eye	0.76680624
92	MP0005187_abnormal_penis_morphology	0.76367763
93	MP0004043_abnormal_pH_regulation	0.75734595
94	MP0002638_abnormal_pupillary_reflex	0.75522926
95	MP0003111_abnormal_nucleus_morphology	0.75122442
96	MP0000537_abnormal_urethra_morphology	0.74794268
97	MP0004142_abnormal_muscle_tone	0.73752195
98	MP0001299_abnormal_eye_distance/	0.73720155
99	MP0004742_abnormal_vestibular_system	0.73462349
100	MP0002067_abnormal_sensory_capabilities	0.73409074

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent/shortened dynein arms (HP:0200106)	5.15842760
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.15842760
3	Abnormal respiratory motile cilium morphology (HP:0005938)	4.62524806
4	Abnormal respiratory epithelium morphology (HP:0012253)	4.62524806
5	Abnormal ciliary motility (HP:0012262)	4.19531531
6	Pancreatic fibrosis (HP:0100732)	4.03894608
7	Rib fusion (HP:0000902)	3.97239868
8	Abnormal respiratory motile cilium physiology (HP:0012261)	3.95108682
9	Facial hemangioma (HP:0000329)	3.66978021
10	Pancreatic cysts (HP:0001737)	3.57861345
11	Nephronophthisis (HP:0000090)	3.56394343
12	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.47203043
13	Gait imbalance (HP:0002141)	3.39994429
14	Congenital primary aphakia (HP:0007707)	3.31858594
15	True hermaphroditism (HP:0010459)	3.31550063
16	Rhinitis (HP:0012384)	3.28740642
17	Medial flaring of the eyebrow (HP:0010747)	3.25637950
18	Molar tooth sign on MRI (HP:0002419)	3.23826508
19	Abnormality of midbrain morphology (HP:0002418)	3.23826508
20	Cystic liver disease (HP:0006706)	3.07540410
21	Preaxial hand polydactyly (HP:0001177)	2.94382746
22	Nephrogenic diabetes insipidus (HP:0009806)	2.94238628
23	Hyperglycinemia (HP:0002154)	2.83286871
24	Postaxial foot polydactyly (HP:0001830)	2.72243790
25	Vaginal atresia (HP:0000148)	2.67414604
26	Chronic bronchitis (HP:0004469)	2.66059998
27	Abnormality of the renal medulla (HP:0100957)	2.64933142
28	Abnormality of the labia minora (HP:0012880)	2.64429130
29	Decreased central vision (HP:0007663)	2.63050906
30	Genital tract atresia (HP:0001827)	2.57122579
31	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.51963858
32	Sclerocornea (HP:0000647)	2.51954034
33	High anterior hairline (HP:0009890)	2.51768814
34	Pendular nystagmus (HP:0012043)	2.50841113
35	Poor coordination (HP:0002370)	2.48465072
36	Postaxial hand polydactyly (HP:0001162)	2.45936618
37	Abnormal number of erythroid precursors (HP:0012131)	2.41100304
38	Oligodactyly (HP:0012165)	2.40965851
39	Attenuation of retinal blood vessels (HP:0007843)	2.35507803
40	Median cleft lip (HP:0000161)	2.35182116
41	Colon cancer (HP:0003003)	2.33983662
42	Optic nerve coloboma (HP:0000588)	2.33296667
43	Abnormality of cells of the erythroid lineage (HP:0012130)	2.25988506
44	Capillary hemangiomas (HP:0005306)	2.23065395
45	Chronic hepatic failure (HP:0100626)	2.20744468
46	Cerebellar dysplasia (HP:0007033)	2.19083453
47	Renal dysplasia (HP:0000110)	2.18732749
48	Decreased testicular size (HP:0008734)	2.18532708
49	Congenital hepatic fibrosis (HP:0002612)	2.16106319
50	Abnormality of the diencephalon (HP:0010662)	2.15664855
51	Type II lissencephaly (HP:0007260)	2.15430063
52	Abnormality of the metopic suture (HP:0005556)	2.15226117
53	Anencephaly (HP:0002323)	2.13035431
54	Occipital encephalocele (HP:0002085)	2.12487573
55	Multicystic kidney dysplasia (HP:0000003)	2.02507193
56	Anophthalmia (HP:0000528)	2.02435652
57	Ectopic kidney (HP:0000086)	1.97635476
58	Bronchiectasis (HP:0002110)	1.94956017
59	Abnormal rod and cone electroretinograms (HP:0008323)	1.94925757
60	Abnormality of abdominal situs (HP:0011620)	1.94835567
61	Abdominal situs inversus (HP:0003363)	1.94835567
62	Impulsivity (HP:0100710)	1.94784293
63	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.90108303
64	Tubular atrophy (HP:0000092)	1.89842523
65	Abnormality of the aortic arch (HP:0012303)	1.89372772
66	Micropenis (HP:0000054)	1.87015636
67	Aganglionic megacolon (HP:0002251)	1.85668045
68	Broad alveolar ridges (HP:0000187)	1.85280038
69	Holoprosencephaly (HP:0001360)	1.82634809
70	Bony spicule pigmentary retinopathy (HP:0007737)	1.81774315
71	Bifid tongue (HP:0010297)	1.81227761
72	Dandy-Walker malformation (HP:0001305)	1.80116525
73	Microvesicular hepatic steatosis (HP:0001414)	1.78059430
74	Broad foot (HP:0001769)	1.77326148
75	Hyperglycinuria (HP:0003108)	1.76703877
76	Aplasia/Hypoplasia of the lens (HP:0008063)	1.76682639
77	Male pseudohermaphroditism (HP:0000037)	1.76047405
78	Hypoplastic pelvis (HP:0008839)	1.75400989
79	Oculomotor apraxia (HP:0000657)	1.74853258
80	Septo-optic dysplasia (HP:0100842)	1.74546441
81	Abnormality of glycine metabolism (HP:0010895)	1.72968864
82	Abnormality of serine family amino acid metabolism (HP:0010894)	1.72968864
83	Abnormal number of incisors (HP:0011064)	1.72906400
84	Tubulointerstitial nephritis (HP:0001970)	1.72324500
85	Neoplasm of the oral cavity (HP:0100649)	1.67752391
86	Microretrognathia (HP:0000308)	1.66804051
87	Adrenal hypoplasia (HP:0000835)	1.66217795
88	Renal hypoplasia (HP:0000089)	1.65717227
89	Methylmalonic acidemia (HP:0002912)	1.65369899
90	Abnormal lung lobation (HP:0002101)	1.64736620
91	Intestinal atresia (HP:0011100)	1.64097023
92	Tachypnea (HP:0002789)	1.63535423
93	Chorioretinal coloboma (HP:0000567)	1.63396078
94	Chronic sinusitis (HP:0011109)	1.61499536
95	Retinal dysplasia (HP:0007973)	1.60060576
96	Abnormality of the phalanges of the hallux (HP:0010057)	1.56684500
97	Specific learning disability (HP:0001328)	1.55225193
98	Hypoplasia of the pons (HP:0012110)	1.53653108
99	Oligodactyly (hands) (HP:0001180)	1.52405685
100	Facial cleft (HP:0002006)	1.52378759

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FGFR2	4.01006480
2	CDK19	3.86062463
3	ZAK	2.86340813
4	MAPK15	2.79582611
5	NTRK2	2.70888701
6	WNK3	2.64443859
7	EPHA4	2.46121308
8	MAP2K7	2.38071500
9	NUAK1	2.25184013
10	PRKD3	2.12747334
11	VRK2	2.10112608
12	TRIM28	2.04535330
13	MKNK1	2.01864606
14	CDC7	1.99774881
15	SRPK1	1.96307476
16	MAP3K4	1.91405269
17	MKNK2	1.90037699
18	WNK4	1.71162426
19	DYRK3	1.59368083
20	BUB1	1.58373805
21	BMPR1B	1.56062736
22	FRK	1.55372170
23	STK16	1.54482950
24	TYRO3	1.53415681
25	MARK1	1.52464499
26	DYRK2	1.51094615
27	TNIK	1.50470036
28	BCKDK	1.46044667
29	RPS6KA4	1.44286029
30	NTRK1	1.41879538
31	CSNK1G2	1.26904346
32	CSNK1G3	1.22088544
33	CSNK1A1L	1.19458634
34	CASK	1.17578902
35	FGFR4	1.10220018
36	NME1	1.07218022
37	CSNK1G1	1.06872346
38	BCR	1.06696628
39	MUSK	1.05636130
40	NEK9	1.00289769
41	PINK1	0.99740092
42	GRK1	0.98777835
43	TTK	0.98552057
44	PLK1	0.94559688
45	PLK3	0.94476486
46	ATR	0.91783229
47	MAP2K4	0.91165915
48	CHEK2	0.85637783
49	MAPK13	0.85467829
50	ADRBK2	0.84691898
51	PLK4	0.80252775
52	TLK1	0.76016894
53	LRRK2	0.74324814
54	PLK2	0.74013375
55	RPS6KA5	0.72663245
56	TSSK6	0.70059116
57	PASK	0.69779762
58	PRKCG	0.67461490
59	VRK1	0.66506396
60	AURKA	0.63618682
61	AURKB	0.63078845
62	OXSR1	0.60505759
63	PRKD2	0.60090899
64	AKT3	0.59786211
65	SGK494	0.58674872
66	SGK223	0.58674872
67	CSNK1E	0.57076400
68	STK11	0.54251698
69	CCNB1	0.54130382
70	PRKCE	0.53369219
71	NEK2	0.52226982
72	PIM2	0.51870210
73	INSRR	0.51586926
74	PBK	0.51437384
75	ATM	0.45566688
76	LIMK1	0.44486426
77	CAMK1	0.44175802
78	AKT2	0.43990783
79	CSNK1D	0.41954650
80	ICK	0.41678365
81	PAK1	0.40843638
82	CHEK1	0.40650942
83	CSNK1A1	0.39493679
84	CDK1	0.39087331
85	CDK3	0.37499429
86	STK24	0.36844315
87	DAPK3	0.36636628
88	DYRK1A	0.36263570
89	CDK2	0.36230981
90	SIK2	0.36230570
91	FLT3	0.35024398
92	ADRBK1	0.34861879
93	PRKACA	0.33712091
94	CAMK2A	0.31865877
95	CDK5	0.29958957
96	MAP4K2	0.29083187
97	MYLK	0.28812511
98	ILK	0.28776255
99	PRKDC	0.28713199
100	PRKCH	0.28465498

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.19717026
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.91724861
3	RNA polymerase_Homo sapiens_hsa03020	2.41168323
4	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.31644614
5	Steroid biosynthesis_Homo sapiens_hsa00100	2.08632926
6	Mismatch repair_Homo sapiens_hsa03430	2.06907748
7	Sulfur relay system_Homo sapiens_hsa04122	2.02047254
8	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.00500889
9	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.99104431
10	Ribosome_Homo sapiens_hsa03010	1.98383627
11	Basal cell carcinoma_Homo sapiens_hsa05217	1.94471633
12	Fanconi anemia pathway_Homo sapiens_hsa03460	1.92188079
13	Non-homologous end-joining_Homo sapiens_hsa03450	1.87530574
14	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.85672722
15	Homologous recombination_Homo sapiens_hsa03440	1.83035573
16	Nicotine addiction_Homo sapiens_hsa05033	1.80758612
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.75795340
18	One carbon pool by folate_Homo sapiens_hsa00670	1.73236692
19	DNA replication_Homo sapiens_hsa03030	1.70913646
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.70001558
21	Huntingtons disease_Homo sapiens_hsa05016	1.56814593
22	Basal transcription factors_Homo sapiens_hsa03022	1.56706903
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.55866282
24	Base excision repair_Homo sapiens_hsa03410	1.53862342
25	Butanoate metabolism_Homo sapiens_hsa00650	1.51661763
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.51483623
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.51138042
28	RNA transport_Homo sapiens_hsa03013	1.37138589
29	Oxidative phosphorylation_Homo sapiens_hsa00190	1.36389332
30	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.35362238
31	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.34011055
32	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.32321700
33	Phototransduction_Homo sapiens_hsa04744	1.29761149
34	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.25913033
35	Taste transduction_Homo sapiens_hsa04742	1.25254872
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.22714549
37	Parkinsons disease_Homo sapiens_hsa05012	1.21761287
38	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.21376668
39	Pyrimidine metabolism_Homo sapiens_hsa00240	1.19107083
40	Spliceosome_Homo sapiens_hsa03040	1.13688132
41	Glutathione metabolism_Homo sapiens_hsa00480	1.13467702
42	Propanoate metabolism_Homo sapiens_hsa00640	1.11714750
43	Folate biosynthesis_Homo sapiens_hsa00790	1.09706464
44	Selenocompound metabolism_Homo sapiens_hsa00450	1.09241344
45	Hippo signaling pathway_Homo sapiens_hsa04390	1.07015521
46	mRNA surveillance pathway_Homo sapiens_hsa03015	1.02041427
47	Purine metabolism_Homo sapiens_hsa00230	1.01585145
48	RNA degradation_Homo sapiens_hsa03018	0.98349303
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.94061936
50	Olfactory transduction_Homo sapiens_hsa04740	0.92034168
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.89640986
52	Protein export_Homo sapiens_hsa03060	0.88962072
53	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.85041036
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.82966652
55	Pyruvate metabolism_Homo sapiens_hsa00620	0.78994999
56	Lysine degradation_Homo sapiens_hsa00310	0.76991717
57	Metabolic pathways_Homo sapiens_hsa01100	0.76398672
58	Alzheimers disease_Homo sapiens_hsa05010	0.75818510
59	Peroxisome_Homo sapiens_hsa04146	0.71924635
60	Cardiac muscle contraction_Homo sapiens_hsa04260	0.71582781
61	Carbon metabolism_Homo sapiens_hsa01200	0.71150928
62	Fatty acid metabolism_Homo sapiens_hsa01212	0.70629755
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.70180185
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68893552
65	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.68577347
66	Fatty acid elongation_Homo sapiens_hsa00062	0.68185311
67	Axon guidance_Homo sapiens_hsa04360	0.67621335
68	Arginine and proline metabolism_Homo sapiens_hsa00330	0.67215252
69	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.66889112
70	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.66669708
71	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.65867891
72	Proteasome_Homo sapiens_hsa03050	0.64339477
73	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.63349264
74	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.61529893
75	Circadian entrainment_Homo sapiens_hsa04713	0.61265419
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61015869
77	Cell cycle_Homo sapiens_hsa04110	0.60258666
78	Wnt signaling pathway_Homo sapiens_hsa04310	0.58490571
79	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.56668772
80	Glutamatergic synapse_Homo sapiens_hsa04724	0.54755980
81	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.53696149
82	GABAergic synapse_Homo sapiens_hsa04727	0.53257408
83	Linoleic acid metabolism_Homo sapiens_hsa00591	0.52877556
84	Cocaine addiction_Homo sapiens_hsa05030	0.52125398
85	Oocyte meiosis_Homo sapiens_hsa04114	0.51586576
86	Melanogenesis_Homo sapiens_hsa04916	0.49465210
87	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.49074578
88	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.48874339
89	Fatty acid degradation_Homo sapiens_hsa00071	0.48266489
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.47365720
91	Alcoholism_Homo sapiens_hsa05034	0.45101626
92	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.43799091
93	Morphine addiction_Homo sapiens_hsa05032	0.43530449
94	Histidine metabolism_Homo sapiens_hsa00340	0.39812934
95	Dopaminergic synapse_Homo sapiens_hsa04728	0.39281926
96	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.38968637
97	Tight junction_Homo sapiens_hsa04530	0.38615623
98	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.36532613
99	Phenylalanine metabolism_Homo sapiens_hsa00360	0.33817819
100	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.33615588

FAM86B1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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