ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	inner mitochondrial membrane organization (GO:0007007)	6.66611633
2	protein complex biogenesis (GO:0070271)	5.39311131
3	positive regulation of glycoprotein biosynthetic process (GO:0010560)	5.30467748
4	respiratory chain complex IV assembly (GO:0008535)	5.29706305
5	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.19467997
6	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.19467997
7	NADH dehydrogenase complex assembly (GO:0010257)	5.19467997
8	mitochondrial respiratory chain complex assembly (GO:0033108)	5.09821970
9	interferon-gamma production (GO:0032609)	5.07342664
10	proteasome assembly (GO:0043248)	5.05417453
11	positive regulation of T cell chemotaxis (GO:0010820)	5.01438018
12	regulation of T cell chemotaxis (GO:0010819)	5.01438018
13	cytochrome complex assembly (GO:0017004)	5.00633614
14	positive regulation of T cell cytokine production (GO:0002726)	4.96355136
15	metallo-sulfur cluster assembly (GO:0031163)	4.82821302
16	iron-sulfur cluster assembly (GO:0016226)	4.82821302
17	positive regulation of glycoprotein metabolic process (GO:1903020)	4.62540577
18	peptidyl-histidine modification (GO:0018202)	4.52793558
19	regulation of hexokinase activity (GO:1903299)	4.46881097
20	regulation of glucokinase activity (GO:0033131)	4.46881097
21	energy homeostasis (GO:0097009)	4.39924860
22	positive regulation of transforming growth factor beta production (GO:0071636)	4.19023280
23	aggressive behavior (GO:0002118)	4.07920157
24	positive regulation of actin filament depolymerization (GO:0030836)	3.86048086
25	lactate metabolic process (GO:0006089)	3.78122246
26	artery smooth muscle contraction (GO:0014824)	3.71939133
27	mannosylation (GO:0097502)	3.64689458
28	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	3.60724696
29	epithelial cilium movement (GO:0003351)	3.58213508
30	negative regulation of T cell mediated immunity (GO:0002710)	3.40940287
31	regulation of T cell cytokine production (GO:0002724)	3.38966787
32	protein neddylation (GO:0045116)	3.35638379
33	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.31375199
34	poly(A)+ mRNA export from nucleus (GO:0016973)	3.27114003
35	platelet dense granule organization (GO:0060155)	3.24470854
36	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	3.24062327
37	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.19006737
38	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	3.18917964
39	regulation of mitochondrial translation (GO:0070129)	3.15683130
40	positive regulation of T-helper 1 type immune response (GO:0002827)	3.12301521
41	cellular ketone body metabolic process (GO:0046950)	3.11532796
42	magnesium ion transport (GO:0015693)	3.10228333
43	DNA double-strand break processing (GO:0000729)	3.09904139
44	phasic smooth muscle contraction (GO:0014821)	3.08656557
45	ubiquinone metabolic process (GO:0006743)	3.08131194
46	tonic smooth muscle contraction (GO:0014820)	3.07912868
47	fructose metabolic process (GO:0006000)	3.01169629
48	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	3.01146582
49	positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)	3.00899759
50	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.95302173
51	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.94996923
52	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.92851612
53	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.92851612
54	urate metabolic process (GO:0046415)	2.92737133
55	synapsis (GO:0007129)	2.92406697
56	sterol biosynthetic process (GO:0016126)	2.91738747
57	chaperone-mediated protein transport (GO:0072321)	2.91384165
58	vascular smooth muscle contraction (GO:0014829)	2.86839338
59	cholesterol biosynthetic process (GO:0006695)	2.86838284
60	DNA damage response, detection of DNA damage (GO:0042769)	2.86259541
61	negative regulation of interleukin-2 production (GO:0032703)	2.83971816
62	preassembly of GPI anchor in ER membrane (GO:0016254)	2.78274121
63	amino-acid betaine metabolic process (GO:0006577)	2.76598141
64	cilium movement (GO:0003341)	2.73788137
65	ketone body metabolic process (GO:1902224)	2.73576171
66	cullin deneddylation (GO:0010388)	2.73571491
67	GPI anchor biosynthetic process (GO:0006506)	2.73272693
68	DNA deamination (GO:0045006)	2.73102393
69	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.68859915
70	ATP synthesis coupled proton transport (GO:0015986)	2.68859915
71	water-soluble vitamin biosynthetic process (GO:0042364)	2.68352214
72	phosphorelay signal transduction system (GO:0000160)	2.64821607
73	isoprenoid biosynthetic process (GO:0008299)	2.64335254
74	GPI anchor metabolic process (GO:0006505)	2.64120289
75	carnitine metabolic process (GO:0009437)	2.63855139
76	behavioral response to nicotine (GO:0035095)	2.61039409
77	regulation of protein glycosylation (GO:0060049)	2.61000588
78	intracellular protein transmembrane import (GO:0044743)	2.60144741
79	negative regulation of Ras GTPase activity (GO:0034261)	2.58334353
80	GDP-mannose metabolic process (GO:0019673)	2.57810509
81	cilium morphogenesis (GO:0060271)	2.57478618
82	lymphocyte chemotaxis (GO:0048247)	2.56995503
83	DNA strand renaturation (GO:0000733)	2.55917519
84	male meiosis (GO:0007140)	2.52411859
85	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.46116495
86	termination of RNA polymerase III transcription (GO:0006386)	2.45455747
87	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.45455747
88	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.44902290
89	kidney morphogenesis (GO:0060993)	2.43658788
90	regulation of lymphocyte chemotaxis (GO:1901623)	2.43365436
91	protein deneddylation (GO:0000338)	2.42992529
92	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.42143151
93	C-terminal protein amino acid modification (GO:0018410)	2.40967759
94	respiratory electron transport chain (GO:0022904)	2.40671282
95	dopamine transport (GO:0015872)	2.40357842
96	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.40274827
97	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.40274827
98	protein targeting to mitochondrion (GO:0006626)	2.38930534
99	DNA catabolic process, exonucleolytic (GO:0000738)	2.38923239
100	oxidative phosphorylation (GO:0006119)	2.37999708

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.01643985
2	ZNF274_21170338_ChIP-Seq_K562_Hela	4.31829313
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.59063133
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.09409783
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.00531290
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.70422029
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.63212286
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.38841166
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.38090282
10	FUS_26573619_Chip-Seq_HEK293_Human	2.29996331
11	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.21758891
12	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.09397161
13	* VDR_22108803_ChIP-Seq_LS180_Human	2.07470874
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.06344989
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.02143261
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.02108061
17	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.98610729
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.91491208
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.84593122
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.82912501
21	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.81062111
22	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.80816159
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.80204566
24	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.80187030
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.78136411
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76684750
27	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.70097527
28	EWS_26573619_Chip-Seq_HEK293_Human	1.68706415
29	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.66510186
30	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.64205431
31	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.63157121
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.61822551
33	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.58053138
34	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.56931655
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.56291862
36	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.53990545
37	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.49703419
38	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46823864
39	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46035959
40	GABP_19822575_ChIP-Seq_HepG2_Human	1.45321807
41	P300_19829295_ChIP-Seq_ESCs_Human	1.43237565
42	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.41278230
43	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.40586280
44	GBX2_23144817_ChIP-Seq_PC3_Human	1.36425688
45	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.36374515
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.34840556
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34356908
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.33635667
49	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.32920106
50	DCP1A_22483619_ChIP-Seq_HELA_Human	1.28807900
51	RNF2_27304074_Chip-Seq_NSC_Mouse	1.22100513
52	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.21210967
53	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.21161253
54	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.20418715
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.19434979
56	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.18036884
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15943496
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15943496
59	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.15704537
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15417128
61	P53_22387025_ChIP-Seq_ESCs_Mouse	1.14705271
62	AR_20517297_ChIP-Seq_VCAP_Human	1.14388434
63	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.10799619
64	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.10760568
65	CBP_20019798_ChIP-Seq_JUKART_Human	1.10760568
66	NCOR_22424771_ChIP-Seq_293T_Human	1.10422103
67	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10012452
68	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09912880
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09756120
70	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.07648613
71	EZH2_22144423_ChIP-Seq_EOC_Human	1.06664308
72	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06448486
73	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.05000152
74	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.04448810
75	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.04262263
76	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.04015520
77	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.03953463
78	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.03736219
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03601095
80	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.03174006
81	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.01104675
82	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.01011513
83	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.00806841
84	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00209544
85	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.00169109
86	HTT_18923047_ChIP-ChIP_STHdh_Human	0.99985021
87	P300_18555785_Chip-Seq_ESCs_Mouse	0.98962819
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98765539
89	PHF8_20622853_ChIP-Seq_HELA_Human	0.98299222
90	NFYB_21822215_ChIP-Seq_K562_Human	0.97480964
91	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97384827
92	SMAD4_21799915_ChIP-Seq_A2780_Human	0.97350576
93	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.96729823
94	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.95539205
95	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.95305434
96	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.95094280
97	ZFX_18555785_Chip-Seq_ESCs_Mouse	0.94358666
98	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.94313185
99	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.93685087
100	STAT3_23295773_ChIP-Seq_U87_Human	0.93108609

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	5.18459978
2	MP0002938_white_spotting	4.49658996
3	MP0003787_abnormal_imprinting	3.35329628
4	MP0006292_abnormal_olfactory_placode	3.02255584
5	MP0006054_spinal_hemorrhage	2.76020296
6	MP0002653_abnormal_ependyma_morphology	2.72968598
7	MP0008995_early_reproductive_senescence	2.68638821
8	MP0001984_abnormal_olfaction	2.63724189
9	MP0000647_abnormal_sebaceous_gland	2.50789244
10	MP0008877_abnormal_DNA_methylation	2.35772021
11	MP0001986_abnormal_taste_sensitivity	2.21314564
12	MP0003718_maternal_effect	2.17292332
13	MP0005174_abnormal_tail_pigmentation	2.14778121
14	MP0003121_genomic_imprinting	2.09255796
15	MP0005253_abnormal_eye_physiology	2.04180169
16	MP0005645_abnormal_hypothalamus_physiol	1.99464842
17	MP0005187_abnormal_penis_morphology	1.97030800
18	MP0001529_abnormal_vocalization	1.90571852
19	MP0003786_premature_aging	1.87223727
20	MP0002736_abnormal_nociception_after	1.84865800
21	MP0003122_maternal_imprinting	1.83997134
22	MP0008058_abnormal_DNA_repair	1.80318236
23	MP0008789_abnormal_olfactory_epithelium	1.79631852
24	MP0006072_abnormal_retinal_apoptosis	1.76921715
25	MP0005499_abnormal_olfactory_system	1.75145142
26	MP0005394_taste/olfaction_phenotype	1.75145142
27	MP0000566_synostosis	1.73839316
28	MP0003806_abnormal_nucleotide_metabolis	1.68368831
29	MP0000613_abnormal_salivary_gland	1.60775697
30	MP0006035_abnormal_mitochondrial_morpho	1.58860187
31	MP0004133_heterotaxia	1.57129662
32	MP0002751_abnormal_autonomic_nervous	1.54944848
33	MP0001968_abnormal_touch/_nociception	1.54878117
34	MP0005075_abnormal_melanosome_morpholog	1.53885724
35	MP0003315_abnormal_perineum_morphology	1.53607719
36	MP0002006_tumorigenesis	1.50096056
37	MP0003011_delayed_dark_adaptation	1.48897583
38	MP0004147_increased_porphyrin_level	1.44619326
39	MP0003123_paternal_imprinting	1.37479448
40	MP0010094_abnormal_chromosome_stability	1.32982656
41	MP0000013_abnormal_adipose_tissue	1.29708343
42	MP0002557_abnormal_social/conspecific_i	1.28495021
43	MP0005551_abnormal_eye_electrophysiolog	1.23399524
44	MP0002234_abnormal_pharynx_morphology	1.23258187
45	MP0000427_abnormal_hair_cycle	1.21676555
46	MP0006276_abnormal_autonomic_nervous	1.21017774
47	MP0001293_anophthalmia	1.20759486
48	MP0002102_abnormal_ear_morphology	1.17128797
49	MP0002254_reproductive_system_inflammat	1.15743177
50	MP0006036_abnormal_mitochondrial_physio	1.11696091
51	MP0005310_abnormal_salivary_gland	1.10588796
52	MP0005085_abnormal_gallbladder_physiolo	1.05242115
53	MP0004957_abnormal_blastocyst_morpholog	1.02819921
54	MP0004142_abnormal_muscle_tone	1.01586943
55	MP0008875_abnormal_xenobiotic_pharmacok	1.00127399
56	MP0008932_abnormal_embryonic_tissue	0.99796965
57	MP0003119_abnormal_digestive_system	0.99584414
58	MP0001764_abnormal_homeostasis	0.99024989
59	MP0003646_muscle_fatigue	0.98862003
60	MP0002909_abnormal_adrenal_gland	0.95289650
61	MP0002095_abnormal_skin_pigmentation	0.95068930
62	MP0009745_abnormal_behavioral_response	0.94111956
63	MP0005391_vision/eye_phenotype	0.93395024
64	MP0002163_abnormal_gland_morphology	0.93097878
65	MP0005395_other_phenotype	0.91487481
66	MP0001485_abnormal_pinna_reflex	0.90850631
67	MP0002090_abnormal_vision	0.90534747
68	MP0000358_abnormal_cell_content/	0.88970580
69	MP0002572_abnormal_emotion/affect_behav	0.88774306
70	MP0000372_irregular_coat_pigmentation	0.88483409
71	MP0000049_abnormal_middle_ear	0.87094886
72	MP0001501_abnormal_sleep_pattern	0.85783740
73	MP0002139_abnormal_hepatobiliary_system	0.84569777
74	MP0002277_abnormal_respiratory_mucosa	0.83313343
75	MP0008872_abnormal_physiological_respon	0.81640011
76	MP0001963_abnormal_hearing_physiology	0.81213794
77	MP0000778_abnormal_nervous_system	0.80597193
78	MP0004885_abnormal_endolymph	0.79797313
79	MP0003186_abnormal_redox_activity	0.79558067
80	MP0004134_abnormal_chest_morphology	0.78611141
81	MP0001661_extended_life_span	0.77196105
82	MP0000026_abnormal_inner_ear	0.76709452
83	MP0002272_abnormal_nervous_system	0.76701221
84	MP0003136_yellow_coat_color	0.76507212
85	MP0001929_abnormal_gametogenesis	0.76382873
86	MP0002233_abnormal_nose_morphology	0.74989340
87	MP0003698_abnormal_male_reproductive	0.74367271
88	MP0004215_abnormal_myocardial_fiber	0.74075638
89	MP0009046_muscle_twitch	0.73237289
90	MP0000653_abnormal_sex_gland	0.71820606
91	MP0000751_myopathy	0.71766471
92	MP0002160_abnormal_reproductive_system	0.71715308
93	MP0002638_abnormal_pupillary_reflex	0.71394968
94	MP0003755_abnormal_palate_morphology	0.71074571
95	MP0000631_abnormal_neuroendocrine_gland	0.69778207
96	MP0002067_abnormal_sensory_capabilities	0.66403413
97	MP0002734_abnormal_mechanical_nocicepti	0.65697068
98	MP0010329_abnormal_lipoprotein_level	0.64153264
99	MP0002210_abnormal_sex_determination	0.62978598
100	MP0001145_abnormal_male_reproductive	0.61308233

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hepatocellular necrosis (HP:0001404)	4.29204635
2	Hepatic necrosis (HP:0002605)	4.06296359
3	Microvesicular hepatic steatosis (HP:0001414)	3.79309243
4	Abnormality of the labia minora (HP:0012880)	3.62090215
5	Mitochondrial inheritance (HP:0001427)	3.53957278
6	Acute necrotizing encephalopathy (HP:0006965)	3.42042561
7	Type II lissencephaly (HP:0007260)	3.35974509
8	Retrobulbar optic neuritis (HP:0100654)	3.34087056
9	Optic neuritis (HP:0100653)	3.34087056
10	Amniotic constriction ring (HP:0009775)	3.26637387
11	Abnormality of placental membranes (HP:0011409)	3.26637387
12	Increased CSF lactate (HP:0002490)	3.25405512
13	Abnormal mitochondria in muscle tissue (HP:0008316)	3.24441474
14	Palpebral edema (HP:0100540)	3.16191304
15	Acute encephalopathy (HP:0006846)	3.13294798
16	3-Methylglutaconic aciduria (HP:0003535)	3.07800733
17	Type I transferrin isoform profile (HP:0003642)	3.06957775
18	Progressive macrocephaly (HP:0004481)	3.03342690
19	Pancreatic cysts (HP:0001737)	3.01289710
20	Hypothermia (HP:0002045)	2.91439364
21	Abnormality of midbrain morphology (HP:0002418)	2.89630341
22	Molar tooth sign on MRI (HP:0002419)	2.89630341
23	Abnormality of the pons (HP:0007361)	2.87672967
24	Hypoplasia of the pons (HP:0012110)	2.84127419
25	True hermaphroditism (HP:0010459)	2.75509005
26	Hypoplastic ischia (HP:0003175)	2.75428180
27	Pancreatic fibrosis (HP:0100732)	2.74607976
28	Congenital stationary night blindness (HP:0007642)	2.70713934
29	Abnormal protein glycosylation (HP:0012346)	2.70433080
30	Abnormal glycosylation (HP:0012345)	2.70433080
31	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.70433080
32	Abnormal protein N-linked glycosylation (HP:0012347)	2.70433080
33	Cerebral hypomyelination (HP:0006808)	2.68351099
34	Disproportionate short-trunk short stature (HP:0003521)	2.60392605
35	Orchitis (HP:0100796)	2.56912257
36	Cerebellar dysplasia (HP:0007033)	2.49100254
37	Neuroendocrine neoplasm (HP:0100634)	2.43943703
38	Medial flaring of the eyebrow (HP:0010747)	2.43921609
39	Increased serum pyruvate (HP:0003542)	2.43405865
40	Fetal akinesia sequence (HP:0001989)	2.42372841
41	Nephronophthisis (HP:0000090)	2.38773357
42	Retinal dysplasia (HP:0007973)	2.34229997
43	CNS demyelination (HP:0007305)	2.33668839
44	Abnormality of the ischium (HP:0003174)	2.31486024
45	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.29368707
46	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.29368707
47	Cutaneous melanoma (HP:0012056)	2.26364340
48	Increased serum lactate (HP:0002151)	2.25670115
49	Patchy hypopigmentation of hair (HP:0011365)	2.20207822
50	Urethral obstruction (HP:0000796)	2.20012114
51	Keratoconjunctivitis (HP:0001096)	2.18531560
52	Occipital encephalocele (HP:0002085)	2.14601962
53	Neoplasm of the adrenal gland (HP:0100631)	2.13902042
54	Increased hepatocellular lipid droplets (HP:0006565)	2.13834011
55	Respiratory failure (HP:0002878)	2.10817278
56	Abnormality of the antihelix (HP:0009738)	2.08951715
57	Cerebral edema (HP:0002181)	2.08106344
58	Abnormality of glycolysis (HP:0004366)	2.07857663
59	Chronic hepatic failure (HP:0100626)	2.06320941
60	Intestinal atresia (HP:0011100)	2.05385541
61	Neoplasm of the oral cavity (HP:0100649)	2.04680695
62	Gait imbalance (HP:0002141)	2.03380739
63	Congenital primary aphakia (HP:0007707)	1.99664299
64	Cortical visual impairment (HP:0100704)	1.97540201
65	Pheochromocytoma (HP:0002666)	1.97450075
66	Sclerocornea (HP:0000647)	1.96012251
67	Neoplasm of the adrenal cortex (HP:0100641)	1.95834453
68	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.95058941
69	Gaze-evoked nystagmus (HP:0000640)	1.94325653
70	Emotional lability (HP:0000712)	1.94055729
71	Type 2 muscle fiber atrophy (HP:0003554)	1.93400535
72	Abnormal respiratory epithelium morphology (HP:0012253)	1.93374885
73	Abnormal respiratory motile cilium morphology (HP:0005938)	1.93374885
74	Abnormality of lateral ventricle (HP:0030047)	1.91998243
75	Abnormal ciliary motility (HP:0012262)	1.91802120
76	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.90596911
77	Absent speech (HP:0001344)	1.88560371
78	Poor suck (HP:0002033)	1.84765824
79	Myositis (HP:0100614)	1.84538755
80	Lactic acidosis (HP:0003128)	1.84477556
81	Nephrogenic diabetes insipidus (HP:0009806)	1.83715709
82	Lissencephaly (HP:0001339)	1.80991131
83	Cystic liver disease (HP:0006706)	1.80622970
84	Tubulointerstitial nephritis (HP:0001970)	1.80546348
85	Keratoconjunctivitis sicca (HP:0001097)	1.79598101
86	Pendular nystagmus (HP:0012043)	1.79001998
87	Lipid accumulation in hepatocytes (HP:0006561)	1.78031364
88	Colon cancer (HP:0003003)	1.77865745
89	White forelock (HP:0002211)	1.77004871
90	Prolonged QT interval (HP:0001657)	1.76651019
91	Dry hair (HP:0011359)	1.75412521
92	Optic nerve hypoplasia (HP:0000609)	1.75328659
93	Keratitis (HP:0000491)	1.74569380
94	Abnormal auditory evoked potentials (HP:0006958)	1.74467490
95	Abnormality of abdominal situs (HP:0011620)	1.71955098
96	Abdominal situs inversus (HP:0003363)	1.71955098
97	Postaxial foot polydactyly (HP:0001830)	1.71672162
98	Horizontal nystagmus (HP:0000666)	1.68163016
99	Thyroiditis (HP:0100646)	1.67970764
100	Decreased central vision (HP:0007663)	1.67491317

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NEK9	6.73389871
2	CDK19	4.58954796
3	SRPK1	3.04317507
4	ZAK	2.79574342
5	FRK	2.67725599
6	MAP4K2	2.43044985
7	NEK1	2.28011660
8	VRK2	2.05625550
9	WNK3	1.99765187
10	GRK1	1.89669921
11	MAP3K12	1.85671908
12	MKNK2	1.75607272
13	MKNK1	1.74320065
14	CSNK1G2	1.73309210
15	STK24	1.66668669
16	TRIM28	1.63390037
17	TSSK6	1.61751728
18	WNK4	1.54257171
19	RPS6KA4	1.51903089
20	ADRBK2	1.45875336
21	EPHA3	1.42075636
22	CSNK1G3	1.39691910
23	CASK	1.37409989
24	TLK1	1.37368668
25	MAPK13	1.34907036
26	CSNK1G1	1.30033416
27	LIMK1	1.29973526
28	PLK3	1.29039331
29	PLK2	1.27540428
30	PRKD3	1.23468667
31	FGFR2	1.22054175
32	OXSR1	1.18395098
33	PTK2B	1.15499792
34	MAP2K7	1.14811296
35	NME1	1.09659810
36	UHMK1	1.05849859
37	BRSK2	1.02512707
38	STK38L	1.00551929
39	MAP3K4	1.00144383
40	VRK1	0.99645237
41	MST4	0.96022107
42	TIE1	0.92734951
43	BCKDK	0.92171381
44	PINK1	0.91296732
45	NUAK1	0.90271816
46	PLK1	0.88827318
47	MARK1	0.86731253
48	DYRK3	0.85601983
49	BUB1	0.84911828
50	CSNK1A1L	0.83132376
51	DYRK2	0.82395477
52	BCR	0.80512007
53	ERBB3	0.78955823
54	BMPR1B	0.78162321
55	PRKCE	0.77634277
56	PAK4	0.76280070
57	EIF2AK3	0.74294934
58	FER	0.70976446
59	NTRK2	0.70945185
60	ILK	0.67688759
61	TAOK3	0.67486407
62	PHKG2	0.66536217
63	PHKG1	0.66536217
64	TESK1	0.65172298
65	OBSCN	0.62727577
66	ERBB2	0.62138513
67	EIF2AK1	0.60807291
68	CAMK2A	0.59950590
69	CAMKK2	0.59902878
70	PLK4	0.59365548
71	CHEK2	0.55546737
72	PRKCG	0.54154418
73	CDK3	0.54086232
74	CAMK2B	0.48303542
75	CDC7	0.48046851
76	DYRK1B	0.47205408
77	ACVR1B	0.46787408
78	BRSK1	0.46205255
79	TTK	0.45805095
80	INSRR	0.45784536
81	CAMK2D	0.44462008
82	DAPK1	0.43941042
83	EPHB2	0.41653048
84	ATR	0.41369700
85	PBK	0.41078407
86	RPS6KA5	0.39697839
87	PKN1	0.39033322
88	MYLK	0.36495664
89	CSNK2A1	0.36118966
90	CAMK4	0.35466468
91	CSNK1A1	0.35341905
92	PASK	0.34544352
93	CSNK1D	0.32857958
94	ATM	0.31891708
95	AURKA	0.31703703
96	MAP2K4	0.31652512
97	ROCK1	0.30588005
98	CAMK1	0.29842426
99	PTK6	0.29792558
100	PIK3CG	0.29494113

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.85578248
2	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.56000687
3	Steroid biosynthesis_Homo sapiens_hsa00100	3.29266018
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.63872157
5	Non-homologous end-joining_Homo sapiens_hsa03450	2.52284947
6	Proteasome_Homo sapiens_hsa03050	2.49068223
7	Protein export_Homo sapiens_hsa03060	2.48315356
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.44221532
9	RNA polymerase_Homo sapiens_hsa03020	2.34687566
10	Butanoate metabolism_Homo sapiens_hsa00650	2.27398592
11	Parkinsons disease_Homo sapiens_hsa05012	2.21288110
12	Basal transcription factors_Homo sapiens_hsa03022	2.08358717
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.07525028
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.01161407
15	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.93975339
16	Homologous recombination_Homo sapiens_hsa03440	1.86116212
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.74532317
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.73396134
19	Propanoate metabolism_Homo sapiens_hsa00640	1.62395372
20	Huntingtons disease_Homo sapiens_hsa05016	1.55543819
21	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.44700705
22	Fatty acid metabolism_Homo sapiens_hsa01212	1.36362976
23	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.31064790
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.31019270
25	Mismatch repair_Homo sapiens_hsa03430	1.30301291
26	Alzheimers disease_Homo sapiens_hsa05010	1.28039047
27	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.23319621
28	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.21064998
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.20363164
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.19344240
31	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.18353207
32	Pyruvate metabolism_Homo sapiens_hsa00620	1.16800093
33	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.15685763
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.09743212
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.08372216
36	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.05427614
37	Fatty acid elongation_Homo sapiens_hsa00062	1.05071203
38	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.03139304
39	Peroxisome_Homo sapiens_hsa04146	1.01479069
40	Sulfur relay system_Homo sapiens_hsa04122	1.01133103
41	Folate biosynthesis_Homo sapiens_hsa00790	1.00091129
42	Linoleic acid metabolism_Homo sapiens_hsa00591	0.99555838
43	DNA replication_Homo sapiens_hsa03030	0.98526777
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.98354582
45	RNA transport_Homo sapiens_hsa03013	0.95765861
46	Spliceosome_Homo sapiens_hsa03040	0.94138692
47	Fatty acid degradation_Homo sapiens_hsa00071	0.92182462
48	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.91893322
49	Metabolic pathways_Homo sapiens_hsa01100	0.91040522
50	Purine metabolism_Homo sapiens_hsa00230	0.87332147
51	Glutathione metabolism_Homo sapiens_hsa00480	0.87296586
52	Nicotine addiction_Homo sapiens_hsa05033	0.86920848
53	Nitrogen metabolism_Homo sapiens_hsa00910	0.86781341
54	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.86618882
55	Fanconi anemia pathway_Homo sapiens_hsa03460	0.86446152
56	Phototransduction_Homo sapiens_hsa04744	0.85851804
57	Carbon metabolism_Homo sapiens_hsa01200	0.85723410
58	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.84647306
59	Base excision repair_Homo sapiens_hsa03410	0.82568379
60	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.79752962
61	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.79610916
62	Circadian rhythm_Homo sapiens_hsa04710	0.77291582
63	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.75257156
64	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.73259542
65	One carbon pool by folate_Homo sapiens_hsa00670	0.72411894
66	GABAergic synapse_Homo sapiens_hsa04727	0.70653415
67	Ribosome_Homo sapiens_hsa03010	0.70549302
68	RNA degradation_Homo sapiens_hsa03018	0.69670146
69	Cardiac muscle contraction_Homo sapiens_hsa04260	0.68473504
70	Taste transduction_Homo sapiens_hsa04742	0.67892930
71	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.67539746
72	Tryptophan metabolism_Homo sapiens_hsa00380	0.66661511
73	Arginine and proline metabolism_Homo sapiens_hsa00330	0.64639151
74	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.63834742
75	Ether lipid metabolism_Homo sapiens_hsa00565	0.61846791
76	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.60908740
77	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.59378697
78	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.54871228
79	Chemical carcinogenesis_Homo sapiens_hsa05204	0.52810193
80	Caffeine metabolism_Homo sapiens_hsa00232	0.52361090
81	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.51397140
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.49765845
83	p53 signaling pathway_Homo sapiens_hsa04115	0.47419803
84	Retinol metabolism_Homo sapiens_hsa00830	0.47263349
85	Primary immunodeficiency_Homo sapiens_hsa05340	0.45723727
86	Oocyte meiosis_Homo sapiens_hsa04114	0.43527985
87	Selenocompound metabolism_Homo sapiens_hsa00450	0.42839211
88	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.41947531
89	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41937955
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41219155
91	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.39473818
92	beta-Alanine metabolism_Homo sapiens_hsa00410	0.39341217
93	Morphine addiction_Homo sapiens_hsa05032	0.38924272
94	Lysine degradation_Homo sapiens_hsa00310	0.37955379
95	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.37790429
96	Serotonergic synapse_Homo sapiens_hsa04726	0.37512009
97	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.34147573
98	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.33580500
99	Pentose phosphate pathway_Homo sapiens_hsa00030	0.32057718
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.31585068

FAM86B2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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