ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	detection of light stimulus involved in sensory perception (GO:0050962)	4.61110662
2	detection of light stimulus involved in visual perception (GO:0050908)	4.61110662
3	behavioral response to nicotine (GO:0035095)	4.47130436
4	meiotic chromosome segregation (GO:0045132)	4.40766821
5	cilium or flagellum-dependent cell motility (GO:0001539)	4.35010062
6	cellular response to ATP (GO:0071318)	4.20243548
7	respiratory chain complex IV assembly (GO:0008535)	3.93565260
8	DNA strand renaturation (GO:0000733)	3.86408072
9	rRNA catabolic process (GO:0016075)	3.85095334
10	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.82002990
11	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.82002990
12	reciprocal DNA recombination (GO:0035825)	3.78957901
13	reciprocal meiotic recombination (GO:0007131)	3.78957901
14	DNA deamination (GO:0045006)	3.76503341
15	tryptophan catabolic process (GO:0006569)	3.75526819
16	indole-containing compound catabolic process (GO:0042436)	3.75526819
17	indolalkylamine catabolic process (GO:0046218)	3.75526819
18	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.72139020
19	response to pheromone (GO:0019236)	3.69156422
20	kynurenine metabolic process (GO:0070189)	3.63821271
21	cytochrome complex assembly (GO:0017004)	3.60246448
22	tRNA modification (GO:0006400)	3.50383224
23	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.42412996
24	replication fork processing (GO:0031297)	3.41819558
25	indolalkylamine metabolic process (GO:0006586)	3.37999119
26	rRNA methylation (GO:0031167)	3.37548340
27	DNA replication checkpoint (GO:0000076)	3.37343766
28	L-fucose metabolic process (GO:0042354)	3.30675382
29	L-fucose catabolic process (GO:0042355)	3.30675382
30	fucose catabolic process (GO:0019317)	3.30675382
31	rRNA modification (GO:0000154)	3.30607102
32	tryptophan metabolic process (GO:0006568)	3.24091477
33	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.20297379
34	regulation of mitotic spindle checkpoint (GO:1903504)	3.20297379
35	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.19013354
36	peptidyl-histidine modification (GO:0018202)	3.10859528
37	epithelial cilium movement (GO:0003351)	3.10620959
38	pseudouridine synthesis (GO:0001522)	3.09713331
39	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.08649382
40	NADH dehydrogenase complex assembly (GO:0010257)	3.08649382
41	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.08649382
42	cellular biogenic amine catabolic process (GO:0042402)	3.08355642
43	amine catabolic process (GO:0009310)	3.08355642
44	regulation of hippo signaling (GO:0035330)	3.07650357
45	organic cation transport (GO:0015695)	3.06799793
46	mitochondrial RNA metabolic process (GO:0000959)	3.04885857
47	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.04071957
48	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.04071957
49	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.02700541
50	preassembly of GPI anchor in ER membrane (GO:0016254)	3.01915417
51	transepithelial transport (GO:0070633)	3.00611946
52	base-excision repair, AP site formation (GO:0006285)	2.99779606
53	negative regulation of telomere maintenance (GO:0032205)	2.99736219
54	mitochondrial respiratory chain complex assembly (GO:0033108)	2.99141848
55	ubiquinone biosynthetic process (GO:0006744)	2.98614184
56	mannosylation (GO:0097502)	2.98121844
57	recombinational repair (GO:0000725)	2.97497285
58	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.97386593
59	photoreceptor cell maintenance (GO:0045494)	2.96434108
60	motile cilium assembly (GO:0044458)	2.96343729
61	double-strand break repair via homologous recombination (GO:0000724)	2.95798103
62	protein complex biogenesis (GO:0070271)	2.92935041
63	regulation of posttranscriptional gene silencing (GO:0060147)	2.91640190
64	regulation of gene silencing by miRNA (GO:0060964)	2.91640190
65	regulation of gene silencing by RNA (GO:0060966)	2.91640190
66	cell wall macromolecule catabolic process (GO:0016998)	2.87453199
67	tRNA processing (GO:0008033)	2.85109188
68	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.83677981
69	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.83677981
70	regulation of translation, ncRNA-mediated (GO:0045974)	2.83677981
71	auditory receptor cell stereocilium organization (GO:0060088)	2.82285364
72	NAD biosynthetic process (GO:0009435)	2.79361448
73	cilium movement (GO:0003341)	2.78832918
74	sulfation (GO:0051923)	2.75373586
75	DNA double-strand break processing (GO:0000729)	2.74388469
76	cilium organization (GO:0044782)	2.73574789
77	ncRNA catabolic process (GO:0034661)	2.71987803
78	axoneme assembly (GO:0035082)	2.71035380
79	sperm motility (GO:0030317)	2.69491680
80	pantothenate metabolic process (GO:0015939)	2.69388289
81	snRNA transcription (GO:0009301)	2.68782711
82	DNA methylation involved in gamete generation (GO:0043046)	2.68007262
83	multicellular organism reproduction (GO:0032504)	2.67564061
84	mitotic cell cycle arrest (GO:0071850)	2.65996540
85	cilium assembly (GO:0042384)	2.65992869
86	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.64734364
87	cell wall macromolecule metabolic process (GO:0044036)	2.64294958
88	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.64055602
89	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.63876343
90	axonemal dynein complex assembly (GO:0070286)	2.63036909
91	ubiquinone metabolic process (GO:0006743)	2.61388919
92	nephron tubule morphogenesis (GO:0072078)	2.58333781
93	nephron epithelium morphogenesis (GO:0072088)	2.58333781
94	regulation of centriole replication (GO:0046599)	2.57445719
95	hematopoietic stem cell proliferation (GO:0071425)	2.56687575
96	regulation of cilium movement (GO:0003352)	2.55434008
97	L-methionine salvage (GO:0071267)	2.54980017
98	L-methionine biosynthetic process (GO:0071265)	2.54980017
99	amino acid salvage (GO:0043102)	2.54980017
100	maturation of 5.8S rRNA (GO:0000460)	2.54757655

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.99398679
2	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.43550188
3	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.12049780
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.07633968
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.91068426
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.88765221
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.82480812
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.69524638
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.67435258
10	VDR_22108803_ChIP-Seq_LS180_Human	2.61730843
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.51067167
12	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.50643987
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.39408711
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.15487015
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.11863220
16	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.05276187
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.04528115
18	E2F7_22180533_ChIP-Seq_HELA_Human	2.04482897
19	FOXP3_21729870_ChIP-Seq_TREG_Human	1.93863172
20	IGF1R_20145208_ChIP-Seq_DFB_Human	1.92618773
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.85204274
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.81691184
23	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.80751331
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.80299320
25	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.77315027
26	ERA_21632823_ChIP-Seq_H3396_Human	1.76158097
27	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.75283142
28	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.70459433
29	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.69057466
30	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.61018221
31	GABP_19822575_ChIP-Seq_HepG2_Human	1.60755370
32	EWS_26573619_Chip-Seq_HEK293_Human	1.60503126
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.60369607
34	E2F1_20622854_ChIP-Seq_HELA_Human	1.59659722
35	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.54465054
36	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.52493070
37	CIITA_25753668_ChIP-Seq_RAJI_Human	1.50462231
38	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.50072843
39	KDM5A_27292631_Chip-Seq_BREAST_Human	1.49964952
40	XRN2_22483619_ChIP-Seq_HELA_Human	1.47634153
41	FUS_26573619_Chip-Seq_HEK293_Human	1.46823649
42	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.45162625
43	ER_23166858_ChIP-Seq_MCF-7_Human	1.43260229
44	ELK1_19687146_ChIP-ChIP_HELA_Human	1.41101133
45	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.39026644
46	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38869246
47	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.35708647
48	P68_20966046_ChIP-Seq_HELA_Human	1.35526215
49	PHF8_20622854_ChIP-Seq_HELA_Human	1.35497840
50	OCT4_20526341_ChIP-Seq_ESCs_Human	1.33535280
51	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.32667042
52	RAC3_21632823_ChIP-Seq_H3396_Human	1.30664526
53	DCP1A_22483619_ChIP-Seq_HELA_Human	1.29308134
54	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.28352339
55	NANOG_20526341_ChIP-Seq_ESCs_Human	1.27460246
56	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.26981180
57	TTF2_22483619_ChIP-Seq_HELA_Human	1.26645394
58	P53_21459846_ChIP-Seq_SAOS-2_Human	1.24961333
59	MYC_19829295_ChIP-Seq_ESCs_Human	1.22921571
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22207964
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22207964
62	BCL6_27268052_Chip-Seq_Bcells_Human	1.22183669
63	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.21240341
64	AR_20517297_ChIP-Seq_VCAP_Human	1.21043695
65	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.20243547
66	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.19610864
67	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.18756078
68	TAF2_19829295_ChIP-Seq_ESCs_Human	1.17237224
69	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.16048593
70	P300_27268052_Chip-Seq_Bcells_Human	1.15904793
71	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.14998631
72	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.13648502
73	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.12847903
74	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.11524361
75	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.11322547
76	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.11234517
77	NCOR_22424771_ChIP-Seq_293T_Human	1.10568314
78	CTCF_20526341_ChIP-Seq_ESCs_Human	1.10478821
79	BCOR_27268052_Chip-Seq_Bcells_Human	1.09122009
80	HOXB7_26014856_ChIP-Seq_BT474_Human	1.09005761
81	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.08750927
82	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.06175325
83	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.05027034
84	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.04822576
85	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.03301647
86	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.01918478
87	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.01702606
88	GBX2_23144817_ChIP-Seq_PC3_Human	0.98898287
89	MAF_26560356_Chip-Seq_TH2_Human	0.97615844
90	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.96267879
91	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.94810317
92	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.93190418
93	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.91957609
94	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.90200727
95	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89403945
96	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.87883839
97	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.87390739
98	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.85955391
99	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.85480755
100	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.84880649

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.41810074
2	MP0008875_abnormal_xenobiotic_pharmacok	3.33576854
3	MP0001986_abnormal_taste_sensitivity	3.30754770
4	MP0006292_abnormal_olfactory_placode	3.19570610
5	MP0005083_abnormal_biliary_tract	3.03784949
6	MP0003195_calcinosis	2.87653513
7	MP0008058_abnormal_DNA_repair	2.56257656
8	MP0005174_abnormal_tail_pigmentation	2.50149628
9	MP0008877_abnormal_DNA_methylation	2.39784645
10	MP0005551_abnormal_eye_electrophysiolog	2.36305999
11	MP0005377_hearing/vestibular/ear_phenot	2.24361099
12	MP0003878_abnormal_ear_physiology	2.24361099
13	MP0010094_abnormal_chromosome_stability	2.05146214
14	MP0005410_abnormal_fertilization	1.98073539
15	MP0001661_extended_life_span	1.82198309
16	MP0008995_early_reproductive_senescence	1.80872871
17	MP0003718_maternal_effect	1.76445309
18	MP0008872_abnormal_physiological_respon	1.74114148
19	MP0005171_absent_coat_pigmentation	1.69860388
20	MP0004147_increased_porphyrin_level	1.67161510
21	MP0003890_abnormal_embryonic-extraembry	1.67082731
22	MP0002653_abnormal_ependyma_morphology	1.66988306
23	MP0000569_abnormal_digit_pigmentation	1.65208405
24	MP0003693_abnormal_embryo_hatching	1.64571530
25	MP0005084_abnormal_gallbladder_morpholo	1.61070958
26	MP0006072_abnormal_retinal_apoptosis	1.59802996
27	MP0003111_abnormal_nucleus_morphology	1.59552953
28	MP0002132_abnormal_respiratory_system	1.53341119
29	MP0005253_abnormal_eye_physiology	1.51642620
30	MP0002938_white_spotting	1.50928731
31	MP0001324_abnormal_eye_pigmentation	1.48950608
32	MP0001968_abnormal_touch/_nociception	1.48366897
33	MP0005646_abnormal_pituitary_gland	1.45739804
34	MP0003646_muscle_fatigue	1.41423197
35	MP0004133_heterotaxia	1.39618211
36	MP0002928_abnormal_bile_duct	1.39407222
37	MP0001485_abnormal_pinna_reflex	1.38923573
38	MP0001293_anophthalmia	1.35694146
39	MP0009046_muscle_twitch	1.32826808
40	MP0002160_abnormal_reproductive_system	1.31665437
41	MP0000631_abnormal_neuroendocrine_gland	1.30784242
42	MP0001929_abnormal_gametogenesis	1.25736510
43	MP0005423_abnormal_somatic_nervous	1.25695227
44	MP0000015_abnormal_ear_pigmentation	1.25333203
45	MP0002396_abnormal_hematopoietic_system	1.25146533
46	MP0001873_stomach_inflammation	1.24701622
47	MP0003698_abnormal_male_reproductive	1.21793813
48	MP0002102_abnormal_ear_morphology	1.16279787
49	MP0004142_abnormal_muscle_tone	1.15565105
50	MP0001529_abnormal_vocalization	1.15540257
51	MP0005075_abnormal_melanosome_morpholog	1.15013959
52	MP0003172_abnormal_lysosome_physiology	1.13756162
53	MP0003786_premature_aging	1.11327223
54	MP0010030_abnormal_orbit_morphology	1.08306805
55	MP0003119_abnormal_digestive_system	1.07152786
56	MP0006276_abnormal_autonomic_nervous	1.05100530
57	MP0002210_abnormal_sex_determination	1.04747175
58	MP0002234_abnormal_pharynx_morphology	1.03733620
59	MP0006035_abnormal_mitochondrial_morpho	1.03343914
60	MP0001764_abnormal_homeostasis	1.02172085
61	MP0000427_abnormal_hair_cycle	1.00391626
62	MP0002735_abnormal_chemical_nociception	0.98236705
63	MP0008789_abnormal_olfactory_epithelium	0.97820787
64	MP0003567_abnormal_fetal_cardiomyocyte	0.95843200
65	MP0000049_abnormal_middle_ear	0.95770456
66	MP0000470_abnormal_stomach_morphology	0.95165703
67	MP0005365_abnormal_bile_salt	0.94949539
68	MP0001145_abnormal_male_reproductive	0.93480090
69	MP0008007_abnormal_cellular_replicative	0.93131718
70	MP0000383_abnormal_hair_follicle	0.93045888
71	MP0001502_abnormal_circadian_rhythm	0.91071312
72	MP0006036_abnormal_mitochondrial_physio	0.90237476
73	MP0002876_abnormal_thyroid_physiology	0.89554328
74	MP0003077_abnormal_cell_cycle	0.88840774
75	MP0008057_abnormal_DNA_replication	0.88414620
76	MP0004043_abnormal_pH_regulation	0.88192753
77	MP0009278_abnormal_bone_marrow	0.87838762
78	MP0002736_abnormal_nociception_after	0.87834146
79	MP0005389_reproductive_system_phenotype	0.87337418
80	MP0005195_abnormal_posterior_eye	0.85883024
81	MP0005395_other_phenotype	0.84357801
82	MP0005391_vision/eye_phenotype	0.81421792
83	MP0000653_abnormal_sex_gland	0.81299421
84	MP0005332_abnormal_amino_acid	0.80513854
85	MP0005220_abnormal_exocrine_pancreas	0.80341711
86	MP0002138_abnormal_hepatobiliary_system	0.79682042
87	MP0001919_abnormal_reproductive_system	0.76551910
88	MP0000230_abnormal_systemic_arterial	0.74388386
89	MP0005499_abnormal_olfactory_system	0.71802487
90	MP0005394_taste/olfaction_phenotype	0.71802487
91	MP0003806_abnormal_nucleotide_metabolis	0.69817298
92	MP0002837_dystrophic_cardiac_calcinosis	0.69695340
93	MP0003137_abnormal_impulse_conducting	0.68026344
94	MP0001984_abnormal_olfaction	0.67249430
95	MP0005360_urolithiasis	0.65636335
96	MP0004808_abnormal_hematopoietic_stem	0.65078774
97	MP0002752_abnormal_somatic_nervous	0.64462412
98	MP0001905_abnormal_dopamine_level	0.63893780
99	MP0004130_abnormal_muscle_cell	0.63369634
100	MP0003787_abnormal_imprinting	0.63042121

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Attenuation of retinal blood vessels (HP:0007843)	4.19102791
2	Molar tooth sign on MRI (HP:0002419)	4.13155230
3	Abnormality of midbrain morphology (HP:0002418)	4.13155230
4	Pancreatic fibrosis (HP:0100732)	4.06203684
5	Congenital stationary night blindness (HP:0007642)	4.05754753
6	Pancreatic cysts (HP:0001737)	4.02614045
7	True hermaphroditism (HP:0010459)	3.76319110
8	Rib fusion (HP:0000902)	3.50404581
9	Nephronophthisis (HP:0000090)	3.36491249
10	Chronic hepatic failure (HP:0100626)	3.17184780
11	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.14834291
12	Bony spicule pigmentary retinopathy (HP:0007737)	3.08646414
13	Chromsome breakage (HP:0040012)	3.08255100
14	Decreased central vision (HP:0007663)	3.02479491
15	Cystic liver disease (HP:0006706)	2.99803015
16	Abnormality of DNA repair (HP:0003254)	2.92304674
17	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.89137873
18	Cerebellar dysplasia (HP:0007033)	2.83860536
19	Patellar aplasia (HP:0006443)	2.75907788
20	Abnormal biliary tract physiology (HP:0012439)	2.71304589
21	Bile duct proliferation (HP:0001408)	2.71304589
22	Abnormality of the renal medulla (HP:0100957)	2.70804354
23	Absent thumb (HP:0009777)	2.69164998
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.67788918
25	Hypoplasia of the pons (HP:0012110)	2.67095208
26	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.66588402
27	Absent/shortened dynein arms (HP:0200106)	2.66588402
28	Squamous cell carcinoma (HP:0002860)	2.63674442
29	Aplasia/Hypoplasia of the patella (HP:0006498)	2.57715036
30	Abnormality of the pons (HP:0007361)	2.55296861
31	Birth length less than 3rd percentile (HP:0003561)	2.52381966
32	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.52026131
33	Abolished electroretinogram (ERG) (HP:0000550)	2.48393673
34	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.47047780
35	Type II lissencephaly (HP:0007260)	2.43260391
36	Duplicated collecting system (HP:0000081)	2.42180277
37	Sclerocornea (HP:0000647)	2.40040547
38	Abnormality of the renal collecting system (HP:0004742)	2.39307554
39	Tubular atrophy (HP:0000092)	2.35390806
40	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.33412498
41	Abnormality of alanine metabolism (HP:0010916)	2.33412498
42	Hyperalaninemia (HP:0003348)	2.33412498
43	Poikiloderma (HP:0001029)	2.32156447
44	Abnormality of the ileum (HP:0001549)	2.31937386
45	Meckel diverticulum (HP:0002245)	2.29503452
46	Congenital hepatic fibrosis (HP:0002612)	2.28271224
47	Dyschromatopsia (HP:0007641)	2.25771691
48	Abnormal respiratory epithelium morphology (HP:0012253)	2.21821529
49	Abnormal respiratory motile cilium morphology (HP:0005938)	2.21821529
50	Abnormal drinking behavior (HP:0030082)	2.18889123
51	Polydipsia (HP:0001959)	2.18889123
52	Sloping forehead (HP:0000340)	2.17245345
53	Anencephaly (HP:0002323)	2.11966346
54	Abnormal number of erythroid precursors (HP:0012131)	2.07066450
55	Hepatocellular necrosis (HP:0001404)	2.06306102
56	Pendular nystagmus (HP:0012043)	2.05867019
57	Colon cancer (HP:0003003)	2.05666960
58	Rectal fistula (HP:0100590)	2.05227967
59	Rectovaginal fistula (HP:0000143)	2.05227967
60	Mesangial abnormality (HP:0001966)	2.03626070
61	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.02167648
62	Postaxial foot polydactyly (HP:0001830)	2.01638262
63	Anophthalmia (HP:0000528)	1.99295195
64	Inability to walk (HP:0002540)	1.98769834
65	Clubbing of toes (HP:0100760)	1.97936451
66	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.96940739
67	Abnormal ciliary motility (HP:0012262)	1.96864476
68	Ectopic kidney (HP:0000086)	1.96366029
69	Intestinal fistula (HP:0100819)	1.93764650
70	Lipid accumulation in hepatocytes (HP:0006561)	1.93035687
71	Optic nerve coloboma (HP:0000588)	1.92816251
72	Progressive inability to walk (HP:0002505)	1.92191539
73	Partial agenesis of the corpus callosum (HP:0001338)	1.92023516
74	11 pairs of ribs (HP:0000878)	1.90600643
75	Male pseudohermaphroditism (HP:0000037)	1.90251248
76	Short thumb (HP:0009778)	1.87550286
77	Protruding tongue (HP:0010808)	1.87235066
78	Severe visual impairment (HP:0001141)	1.86790660
79	Oligohydramnios (HP:0001562)	1.85694531
80	Abnormality of chromosome stability (HP:0003220)	1.85687113
81	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.84348081
82	Abnormal protein N-linked glycosylation (HP:0012347)	1.84348081
83	Abnormal protein glycosylation (HP:0012346)	1.84348081
84	Abnormal glycosylation (HP:0012345)	1.84348081
85	Absent radius (HP:0003974)	1.82622648
86	Large for gestational age (HP:0001520)	1.81291514
87	Absent forearm bone (HP:0003953)	1.81140616
88	Aplasia involving forearm bones (HP:0009822)	1.81140616
89	Abnormality of cells of the erythroid lineage (HP:0012130)	1.80675475
90	Abnormality of the renal cortex (HP:0011035)	1.80266085
91	Occipital encephalocele (HP:0002085)	1.79319152
92	Abnormality of the preputium (HP:0100587)	1.78487156
93	Reticulocytopenia (HP:0001896)	1.78188522
94	Abnormal respiratory motile cilium physiology (HP:0012261)	1.76468219
95	Bilateral microphthalmos (HP:0007633)	1.75333010
96	Increased CSF lactate (HP:0002490)	1.72016271
97	Enlarged kidneys (HP:0000105)	1.69686409
98	Mitochondrial inheritance (HP:0001427)	1.69484812
99	Small intestinal stenosis (HP:0012848)	1.69477179
100	Duodenal stenosis (HP:0100867)	1.69477179

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	4.47592124
2	ZAK	4.37974606
3	FRK	4.22360272
4	WNK4	3.01064046
5	BMPR1B	2.87753513
6	STK16	2.80226504
7	ADRBK2	2.79973723
8	INSRR	2.54689396
9	PDK2	2.44055094
10	MAPK15	2.41664128
11	ACVR1B	2.34800087
12	GRK1	2.12151253
13	NUAK1	2.11201676
14	MUSK	2.07234476
15	WNK3	2.03696196
16	VRK2	2.03449300
17	TAOK3	1.72238356
18	NME1	1.51228331
19	CAMKK2	1.43472168
20	BRSK2	1.39449788
21	SIK2	1.38964929
22	NEK2	1.32356066
23	PINK1	1.30838014
24	IKBKB	1.29941166
25	ATR	1.22853105
26	MKNK2	1.22536307
27	VRK1	1.20428813
28	CHEK2	1.14250543
29	MAP4K2	1.13777708
30	TXK	1.12407817
31	CDC7	1.10751540
32	MAP2K2	1.06838218
33	MAPKAPK3	1.05015505
34	RPS6KA5	1.04213895
35	MKNK1	1.02757039
36	BCKDK	1.02127688
37	CSNK1G3	1.01884700
38	CSNK1A1L	1.00313950
39	MAPK13	0.98243235
40	CSNK1G1	0.95262643
41	SRPK1	0.94715515
42	CDK12	0.91207104
43	FLT3	0.90620279
44	MAP4K1	0.84038647
45	CDK4	0.83114606
46	ITK	0.82631030
47	STK39	0.82047404
48	MAPK11	0.81362066
49	WNK1	0.81062666
50	ADRBK1	0.79129231
51	TGFBR1	0.78983281
52	OXSR1	0.78937748
53	PLK4	0.73187110
54	GRK6	0.70521756
55	RPS6KA6	0.67295385
56	MARK3	0.65870570
57	TEC	0.65748725
58	CSNK1G2	0.64006540
59	TNIK	0.63484905
60	DYRK2	0.63479582
61	PRKCQ	0.61502941
62	MAPKAPK5	0.59195390
63	PLK1	0.57233025
64	BTK	0.57042880
65	RAF1	0.56888688
66	BUB1	0.54773996
67	DAPK2	0.53409663
68	ATM	0.51145155
69	CAMK1D	0.49843045
70	TRIM28	0.49655551
71	SYK	0.49316974
72	AKT3	0.49015522
73	CDK8	0.48573276
74	CCNB1	0.48084175
75	BLK	0.47148859
76	EIF2AK3	0.46279256
77	PIM1	0.45346741
78	PRKAA1	0.45035434
79	STK11	0.44460093
80	PTK2B	0.43956887
81	PIM2	0.43248206
82	CAMKK1	0.42014085
83	IRAK1	0.39259661
84	NTRK3	0.38003819
85	MAP2K6	0.35903574
86	RPS6KB2	0.33994829
87	MELK	0.33350506
88	AURKA	0.32503923
89	MAP3K7	0.31850486
90	TNK2	0.31148163
91	RPS6KA1	0.31142270
92	JAK3	0.30893691
93	CAMK1G	0.30875671
94	CSNK1D	0.30572871
95	AKT1	0.27966611
96	RPS6KC1	0.27805734
97	RPS6KL1	0.27805734
98	PRKACA	0.26247304
99	PRKAA2	0.25775597
100	LYN	0.24577674

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.49727954
2	Selenocompound metabolism_Homo sapiens_hsa00450	3.39770458
3	Homologous recombination_Homo sapiens_hsa03440	3.28693582
4	Fanconi anemia pathway_Homo sapiens_hsa03460	3.07210275
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.67553736
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.67042423
7	RNA polymerase_Homo sapiens_hsa03020	2.56907856
8	Phototransduction_Homo sapiens_hsa04744	2.40234433
9	One carbon pool by folate_Homo sapiens_hsa00670	2.29228134
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.10984743
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.08087114
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.97384449
13	Base excision repair_Homo sapiens_hsa03410	1.89009597
14	Butanoate metabolism_Homo sapiens_hsa00650	1.87504953
15	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.76467459
16	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.68625257
17	Non-homologous end-joining_Homo sapiens_hsa03450	1.65718855
18	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.65389150
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.65090867
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.63376811
21	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.63083306
22	Sulfur relay system_Homo sapiens_hsa04122	1.62702882
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.62660273
24	Basal transcription factors_Homo sapiens_hsa03022	1.55029935
25	DNA replication_Homo sapiens_hsa03030	1.54899520
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.54676309
27	Olfactory transduction_Homo sapiens_hsa04740	1.54486953
28	Taste transduction_Homo sapiens_hsa04742	1.53751329
29	RNA degradation_Homo sapiens_hsa03018	1.51438640
30	Ribosome_Homo sapiens_hsa03010	1.42837899
31	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.34557778
32	Mismatch repair_Homo sapiens_hsa03430	1.25644332
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.24392345
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.24345720
35	Nucleotide excision repair_Homo sapiens_hsa03420	1.18372671
36	Glycerolipid metabolism_Homo sapiens_hsa00561	1.18012040
37	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.17598062
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.16416546
39	Lysine degradation_Homo sapiens_hsa00310	1.16051072
40	ABC transporters_Homo sapiens_hsa02010	1.15785223
41	Purine metabolism_Homo sapiens_hsa00230	1.15746696
42	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.14768203
43	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.10261533
44	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.07614795
45	RNA transport_Homo sapiens_hsa03013	1.07534039
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.06967003
47	Peroxisome_Homo sapiens_hsa04146	1.06894963
48	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.91533037
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.90953182
50	Primary immunodeficiency_Homo sapiens_hsa05340	0.90792086
51	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.87471041
52	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.78796066
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.77381899
54	Spliceosome_Homo sapiens_hsa03040	0.77109287
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75449054
56	Nicotine addiction_Homo sapiens_hsa05033	0.75317379
57	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.75083057
58	Huntingtons disease_Homo sapiens_hsa05016	0.73336079
59	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.72706261
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71347920
61	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.71219591
62	Alcoholism_Homo sapiens_hsa05034	0.70484629
63	Metabolic pathways_Homo sapiens_hsa01100	0.69917121
64	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.69256063
65	Oxidative phosphorylation_Homo sapiens_hsa00190	0.68846846
66	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.66876964
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.63162760
68	Histidine metabolism_Homo sapiens_hsa00340	0.63018907
69	Caffeine metabolism_Homo sapiens_hsa00232	0.61630249
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.59621562
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59189230
72	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.56270454
73	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.54311193
74	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.53877136
75	Morphine addiction_Homo sapiens_hsa05032	0.53388324
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.50835308
77	Regulation of autophagy_Homo sapiens_hsa04140	0.48638214
78	Parkinsons disease_Homo sapiens_hsa05012	0.48478272
79	beta-Alanine metabolism_Homo sapiens_hsa00410	0.48319641
80	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.47028644
81	Basal cell carcinoma_Homo sapiens_hsa05217	0.46118596
82	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.44941130
83	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.43949193
84	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.40936795
85	Retinol metabolism_Homo sapiens_hsa00830	0.40738690
86	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39451285
87	Cell cycle_Homo sapiens_hsa04110	0.35767057
88	Serotonergic synapse_Homo sapiens_hsa04726	0.35005467
89	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.33803223
90	Sphingolipid metabolism_Homo sapiens_hsa00600	0.33581749
91	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.32063901
92	Glutathione metabolism_Homo sapiens_hsa00480	0.30496880
93	Calcium signaling pathway_Homo sapiens_hsa04020	0.30074248
94	Steroid biosynthesis_Homo sapiens_hsa00100	0.29147268
95	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.28353626
96	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.26687362
97	Propanoate metabolism_Homo sapiens_hsa00640	0.26520072
98	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.24727388
99	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.22176383
100	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.17803228

FAM86B3P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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