ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.51637018
2	maturation of 5.8S rRNA (GO:0000460)	4.45755510
3	DNA replication checkpoint (GO:0000076)	4.42801876
4	DNA strand elongation involved in DNA replication (GO:0006271)	4.19574219
5	rRNA modification (GO:0000154)	4.19292108
6	pseudouridine synthesis (GO:0001522)	4.03565265
7	regulation of mitochondrial translation (GO:0070129)	4.01432870
8	DNA strand elongation (GO:0022616)	3.97403251
9	establishment of integrated proviral latency (GO:0075713)	3.92033257
10	telomere maintenance via semi-conservative replication (GO:0032201)	3.85431370
11	water-soluble vitamin biosynthetic process (GO:0042364)	3.82160652
12	chromatin remodeling at centromere (GO:0031055)	3.82009329
13	ribosomal small subunit assembly (GO:0000028)	3.77742581
14	CENP-A containing nucleosome assembly (GO:0034080)	3.77190125
15	purine nucleobase biosynthetic process (GO:0009113)	3.73111425
16	ribosomal small subunit biogenesis (GO:0042274)	3.71789199
17	chaperone-mediated protein transport (GO:0072321)	3.65311921
18	ribosomal large subunit biogenesis (GO:0042273)	3.63841509
19	nucleobase biosynthetic process (GO:0046112)	3.57508069
20	viral transcription (GO:0019083)	3.47595122
21	translational termination (GO:0006415)	3.46679962
22	spliceosomal snRNP assembly (GO:0000387)	3.41321852
23	IMP biosynthetic process (GO:0006188)	3.37985753
24	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.37666077
25	proteasome assembly (GO:0043248)	3.37332773
26	cytochrome complex assembly (GO:0017004)	3.33933372
27	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.31362684
28	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.31002472
29	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.28878769
30	termination of RNA polymerase III transcription (GO:0006386)	3.28878769
31	telomere maintenance via recombination (GO:0000722)	3.28627623
32	respiratory chain complex IV assembly (GO:0008535)	3.28225832
33	cotranslational protein targeting to membrane (GO:0006613)	3.26975060
34	histone exchange (GO:0043486)	3.25211797
35	rRNA methylation (GO:0031167)	3.25184508
36	protein neddylation (GO:0045116)	3.25024580
37	inner mitochondrial membrane organization (GO:0007007)	3.23940146
38	mitochondrial respiratory chain complex assembly (GO:0033108)	3.21658077
39	protein complex biogenesis (GO:0070271)	3.21266892
40	DNA replication-independent nucleosome organization (GO:0034724)	3.20398514
41	DNA replication-independent nucleosome assembly (GO:0006336)	3.20398514
42	protein targeting to ER (GO:0045047)	3.19021276
43	rRNA processing (GO:0006364)	3.18745977
44	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.17448686
45	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.16826237
46	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.16826237
47	ribonucleoprotein complex biogenesis (GO:0022613)	3.14113643
48	mitotic recombination (GO:0006312)	3.13536449
49	DNA replication-dependent nucleosome organization (GO:0034723)	3.13300769
50	DNA replication-dependent nucleosome assembly (GO:0006335)	3.13300769
51	translation (GO:0006412)	3.10394055
52	cellular component biogenesis (GO:0044085)	3.08597504
53	rRNA metabolic process (GO:0016072)	3.08549811
54	L-serine metabolic process (GO:0006563)	3.08519207
55	mitotic metaphase plate congression (GO:0007080)	3.07451060
56	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.06463354
57	ATP synthesis coupled proton transport (GO:0015986)	3.05603667
58	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.05603667
59	translational elongation (GO:0006414)	3.04763078
60	mitochondrial RNA metabolic process (GO:0000959)	3.03865844
61	DNA catabolic process, exonucleolytic (GO:0000738)	3.03511237
62	DNA ligation (GO:0006266)	3.03263894
63	kinetochore organization (GO:0051383)	3.02702218
64	translational initiation (GO:0006413)	3.02421220
65	protein localization to endoplasmic reticulum (GO:0070972)	3.02183753
66	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.00516608
67	DNA double-strand break processing (GO:0000729)	2.99970234
68	DNA unwinding involved in DNA replication (GO:0006268)	2.99042218
69	telomere maintenance via telomere lengthening (GO:0010833)	2.97512039
70	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.95409235
71	NADH dehydrogenase complex assembly (GO:0010257)	2.95409235
72	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.95409235
73	establishment of viral latency (GO:0019043)	2.95149889
74	formation of translation preinitiation complex (GO:0001731)	2.92355148
75	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.92159807
76	DNA replication initiation (GO:0006270)	2.91375871
77	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.91046319
78	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	2.89892248
79	tRNA aminoacylation (GO:0043039)	2.89849697
80	amino acid activation (GO:0043038)	2.89849697
81	tRNA metabolic process (GO:0006399)	2.89333337
82	tRNA aminoacylation for protein translation (GO:0006418)	2.88446090
83	regulation of helicase activity (GO:0051095)	2.87326976
84	tRNA processing (GO:0008033)	2.86926151
85	IMP metabolic process (GO:0046040)	2.86900500
86	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.86569445
87	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.86478702
88	kinetochore assembly (GO:0051382)	2.85794501
89	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.84547144
90	folic acid-containing compound biosynthetic process (GO:0009396)	2.84331173
91	peptidyl-histidine modification (GO:0018202)	2.84301898
92	mitotic sister chromatid segregation (GO:0000070)	2.83835535
93	non-recombinational repair (GO:0000726)	2.83683344
94	double-strand break repair via nonhomologous end joining (GO:0006303)	2.83683344
95	ncRNA metabolic process (GO:0034660)	2.83300224
96	ribosome biogenesis (GO:0042254)	2.82123349
97	regulation of centriole replication (GO:0046599)	2.81638069
98	translesion synthesis (GO:0019985)	2.81238655
99	replication fork processing (GO:0031297)	2.81060270
100	ncRNA processing (GO:0034470)	2.76519991

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.52994614
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.85387202
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.42072220
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.12008213
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.84449927
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.81456301
7	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.68109167
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.39182409
9	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.16190381
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.08645279
11	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.97535043
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.95775176
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.90772879
14	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.78050794
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.77649834
16	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.74278382
17	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.67208909
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.56544658
19	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.55910721
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.52335437
21	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.49065612
22	DCP1A_22483619_ChIP-Seq_HELA_Human	2.34798177
23	FOXP3_21729870_ChIP-Seq_TREG_Human	2.32822587
24	VDR_23849224_ChIP-Seq_CD4+_Human	2.31649645
25	XRN2_22483619_ChIP-Seq_HELA_Human	2.29778172
26	TTF2_22483619_ChIP-Seq_HELA_Human	2.20507201
27	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.17515636
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.15124041
29	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.14052832
30	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.13803486
31	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.10644193
32	GABP_19822575_ChIP-Seq_HepG2_Human	2.04457728
33	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.99739365
34	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.95042401
35	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.90567402
36	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.90294437
37	AR_21909140_ChIP-Seq_LNCAP_Human	1.84692258
38	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.83270146
39	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.80536155
40	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.79788284
41	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.76696395
42	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.76356596
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.76268052
44	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.72943986
45	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.69180859
46	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.63363673
47	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.61545470
48	KDM5A_27292631_Chip-Seq_BREAST_Human	1.58811560
49	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.57587034
50	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.53043097
51	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.49444579
52	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.48417973
53	ZNF274_21170338_ChIP-Seq_K562_Hela	1.43866233
54	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.40924471
55	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.40294246
56	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.37908859
57	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.30108247
58	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.29629600
59	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.27244064
60	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.25923840
61	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.25908681
62	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.25678587
63	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.19879394
64	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.18621238
65	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.13395944
66	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.12933563
67	EWS_26573619_Chip-Seq_HEK293_Human	1.05159104
68	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.04808418
69	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.02974949
70	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.00043571
71	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.99999915
72	IRF1_19129219_ChIP-ChIP_H3396_Human	0.99153780
73	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.97718458
74	CIITA_25753668_ChIP-Seq_RAJI_Human	0.96429160
75	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.95718430
76	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.94479685
77	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.92690434
78	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.91852172
79	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.89177403
80	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.87500637
81	VDR_22108803_ChIP-Seq_LS180_Human	0.86469046
82	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.86094791
83	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.86062268
84	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.85155960
85	FUS_26573619_Chip-Seq_HEK293_Human	0.83834786
86	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.79898214
87	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.78786467
88	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.78579166
89	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.77354961
90	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.76070867
91	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.74921369
92	ELF5_23300383_ChIP-Seq_T47D_Human	0.72151424
93	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.71924657
94	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.68591726
95	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.68392584
96	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.67077922
97	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.66377224
98	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.64390969
99	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.62844575
100	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.61984173

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	4.21621104
2	MP0003693_abnormal_embryo_hatching	4.02775612
3	MP0008058_abnormal_DNA_repair	3.82878919
4	MP0004957_abnormal_blastocyst_morpholog	3.43076368
5	MP0003111_abnormal_nucleus_morphology	2.91685618
6	MP0006292_abnormal_olfactory_placode	2.90765395
7	MP0008877_abnormal_DNA_methylation	2.82421848
8	MP0010030_abnormal_orbit_morphology	2.73517035
9	MP0008789_abnormal_olfactory_epithelium	2.57376556
10	MP0002938_white_spotting	2.54947873
11	MP0003077_abnormal_cell_cycle	2.46357774
12	MP0003718_maternal_effect	2.42179833
13	MP0008932_abnormal_embryonic_tissue	2.32860796
14	MP0001529_abnormal_vocalization	2.24646483
15	MP0003136_yellow_coat_color	2.22360473
16	MP0001293_anophthalmia	2.12394875
17	MP0006035_abnormal_mitochondrial_morpho	2.02977794
18	MP0005499_abnormal_olfactory_system	1.98878284
19	MP0005394_taste/olfaction_phenotype	1.98878284
20	MP0006072_abnormal_retinal_apoptosis	1.82689923
21	MP0008007_abnormal_cellular_replicative	1.81395267
22	MP0000566_synostosis	1.76575525
23	MP0001188_hyperpigmentation	1.72445421
24	MP0009697_abnormal_copulation	1.68111433
25	MP0003186_abnormal_redox_activity	1.65053307
26	MP0004147_increased_porphyrin_level	1.59281967
27	MP0003786_premature_aging	1.56344245
28	MP0006036_abnormal_mitochondrial_physio	1.50893266
29	MP0003195_calcinosis	1.48564342
30	MP0003937_abnormal_limbs/digits/tail_de	1.47332023
31	MP0008057_abnormal_DNA_replication	1.36777885
32	MP0003941_abnormal_skin_development	1.36573528
33	MP0001697_abnormal_embryo_size	1.35850215
34	MP0000350_abnormal_cell_proliferation	1.31009448
35	MP0002210_abnormal_sex_determination	1.30638137
36	MP0000358_abnormal_cell_content/	1.28617504
37	MP0003890_abnormal_embryonic-extraembry	1.28234829
38	MP0000631_abnormal_neuroendocrine_gland	1.27825220
39	MP0002102_abnormal_ear_morphology	1.26249623
40	MP0001730_embryonic_growth_arrest	1.25513533
41	MP0002084_abnormal_developmental_patter	1.23557570
42	MP0003806_abnormal_nucleotide_metabolis	1.23237213
43	MP0001286_abnormal_eye_development	1.23028120
44	MP0004133_heterotaxia	1.22816665
45	MP0003011_delayed_dark_adaptation	1.22185153
46	MP0002085_abnormal_embryonic_tissue	1.21845085
47	MP0001929_abnormal_gametogenesis	1.21826051
48	MP0000372_irregular_coat_pigmentation	1.20333204
49	MP0001984_abnormal_olfaction	1.19956325
50	MP0003119_abnormal_digestive_system	1.19721576
51	MP0002160_abnormal_reproductive_system	1.17255178
52	MP0001145_abnormal_male_reproductive	1.17236764
53	MP0005084_abnormal_gallbladder_morpholo	1.15429543
54	MP0005253_abnormal_eye_physiology	1.13585105
55	MP0002822_catalepsy	1.13295205
56	MP0001672_abnormal_embryogenesis/_devel	1.12624742
57	MP0005380_embryogenesis_phenotype	1.12624742
58	MP0000653_abnormal_sex_gland	1.12413976
59	MP0002254_reproductive_system_inflammat	1.11630892
60	MP0002132_abnormal_respiratory_system	1.10798774
61	MP0002233_abnormal_nose_morphology	1.05848724
62	MP0005408_hypopigmentation	1.03064880
63	MP0009672_abnormal_birth_weight	1.01710096
64	MP0002080_prenatal_lethality	1.00572040
65	MP0005391_vision/eye_phenotype	1.00167676
66	MP0000537_abnormal_urethra_morphology	1.00144795
67	MP0002111_abnormal_tail_morphology	0.99759820
68	MP0003984_embryonic_growth_retardation	0.99195457
69	MP0005248_abnormal_Harderian_gland	0.98812291
70	MP0008875_abnormal_xenobiotic_pharmacok	0.97811197
71	MP0002697_abnormal_eye_size	0.97259191
72	MP0002653_abnormal_ependyma_morphology	0.96710472
73	MP0003698_abnormal_male_reproductive	0.95983223
74	MP0002088_abnormal_embryonic_growth/wei	0.95690474
75	MP0005551_abnormal_eye_electrophysiolog	0.94363079
76	MP0008995_early_reproductive_senescence	0.93786385
77	MP0000313_abnormal_cell_death	0.93457480
78	MP0000049_abnormal_middle_ear	0.93392730
79	MP0004197_abnormal_fetal_growth/weight/	0.92603716
80	MP0002736_abnormal_nociception_after	0.92591424
81	MP0001346_abnormal_lacrimal_gland	0.92443384
82	MP0005220_abnormal_exocrine_pancreas	0.92350894
83	MP0000579_abnormal_nail_morphology	0.89030589
84	MP0000647_abnormal_sebaceous_gland	0.85963128
85	MP0002396_abnormal_hematopoietic_system	0.84288007
86	MP0005377_hearing/vestibular/ear_phenot	0.84285679
87	MP0003878_abnormal_ear_physiology	0.84285679
88	MP0005410_abnormal_fertilization	0.83832976
89	MP0000383_abnormal_hair_follicle	0.83628219
90	MP0005395_other_phenotype	0.83624734
91	MP0002092_abnormal_eye_morphology	0.82997596
92	MP0005389_reproductive_system_phenotype	0.81312338
93	MP0005646_abnormal_pituitary_gland	0.80466813
94	MP0009703_decreased_birth_body	0.80327233
95	MP0003567_abnormal_fetal_cardiomyocyte	0.78904743
96	MP0001324_abnormal_eye_pigmentation	0.77276555
97	MP0003121_genomic_imprinting	0.75745296
98	MP0002234_abnormal_pharynx_morphology	0.75673263
99	MP0001119_abnormal_female_reproductive	0.74253181
100	MP0002019_abnormal_tumor_incidence	0.73073603

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal number of erythroid precursors (HP:0012131)	3.66161388
2	Abnormality of cells of the erythroid lineage (HP:0012130)	3.42831527
3	Hyperglycinemia (HP:0002154)	3.26580843
4	Methylmalonic acidemia (HP:0002912)	3.02442137
5	Acute necrotizing encephalopathy (HP:0006965)	3.01593390
6	Acute encephalopathy (HP:0006846)	2.93701369
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.89699457
8	Absent/shortened dynein arms (HP:0200106)	2.89699457
9	Macrocytic anemia (HP:0001972)	2.87413837
10	Abnormal respiratory motile cilium morphology (HP:0005938)	2.83354354
11	Abnormal respiratory epithelium morphology (HP:0012253)	2.83354354
12	Chromsome breakage (HP:0040012)	2.74755739
13	Abnormal ciliary motility (HP:0012262)	2.74670925
14	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.74537760
15	Reticulocytopenia (HP:0001896)	2.74174255
16	Abnormality of the labia minora (HP:0012880)	2.68324372
17	Abnormal mitochondria in muscle tissue (HP:0008316)	2.68018812
18	Increased CSF lactate (HP:0002490)	2.67808599
19	Abnormal respiratory motile cilium physiology (HP:0012261)	2.67169592
20	Mitochondrial inheritance (HP:0001427)	2.64456835
21	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.61998408
22	Pancreatic fibrosis (HP:0100732)	2.60158465
23	Hepatocellular necrosis (HP:0001404)	2.58540716
24	Birth length less than 3rd percentile (HP:0003561)	2.57790647
25	Chronic bronchitis (HP:0004469)	2.57238945
26	Meckel diverticulum (HP:0002245)	2.53837613
27	Abnormality of the ileum (HP:0001549)	2.52787239
28	Colon cancer (HP:0003003)	2.51582398
29	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.48165667
30	Abnormality of chromosome stability (HP:0003220)	2.47214232
31	Increased hepatocellular lipid droplets (HP:0006565)	2.45936242
32	Medial flaring of the eyebrow (HP:0010747)	2.45405706
33	Type I transferrin isoform profile (HP:0003642)	2.43219281
34	Rhinitis (HP:0012384)	2.42511682
35	Nephrogenic diabetes insipidus (HP:0009806)	2.42452869
36	Abnormality of serum amino acid levels (HP:0003112)	2.40981920
37	Methylmalonic aciduria (HP:0012120)	2.36832697
38	Abdominal situs inversus (HP:0003363)	2.36608822
39	Abnormality of abdominal situs (HP:0011620)	2.36608822
40	Congenital primary aphakia (HP:0007707)	2.36562315
41	Progressive macrocephaly (HP:0004481)	2.35068173
42	Hepatic necrosis (HP:0002605)	2.35010367
43	Lipid accumulation in hepatocytes (HP:0006561)	2.33151677
44	Abnormal lung lobation (HP:0002101)	2.30911177
45	Increased serum lactate (HP:0002151)	2.29969834
46	Abnormality of serine family amino acid metabolism (HP:0010894)	2.28234561
47	Abnormality of glycine metabolism (HP:0010895)	2.28234561
48	Gait imbalance (HP:0002141)	2.26498770
49	True hermaphroditism (HP:0010459)	2.26384669
50	Nephronophthisis (HP:0000090)	2.24763285
51	Abnormality of the preputium (HP:0100587)	2.20165463
52	Abnormality of midbrain morphology (HP:0002418)	2.19582004
53	Molar tooth sign on MRI (HP:0002419)	2.19582004
54	Abnormality of methionine metabolism (HP:0010901)	2.17686165
55	Pancreatic cysts (HP:0001737)	2.17579521
56	Absent thumb (HP:0009777)	2.15964018
57	Cerebral edema (HP:0002181)	2.14562444
58	Reduced antithrombin III activity (HP:0001976)	2.14513542
59	Septo-optic dysplasia (HP:0100842)	2.13866256
60	Pendular nystagmus (HP:0012043)	2.13603686
61	Pallor (HP:0000980)	2.13148762
62	Genital tract atresia (HP:0001827)	2.10201768
63	Ectopic kidney (HP:0000086)	2.07923505
64	Vaginal atresia (HP:0000148)	2.07526739
65	Facial cleft (HP:0002006)	2.05411825
66	Abnormality of homocysteine metabolism (HP:0010919)	2.02815730
67	Homocystinuria (HP:0002156)	2.02815730
68	Median cleft lip (HP:0000161)	2.01783592
69	Pancytopenia (HP:0001876)	1.99343649
70	Testicular atrophy (HP:0000029)	1.98619575
71	Triphalangeal thumb (HP:0001199)	1.96588375
72	Hyperglycinuria (HP:0003108)	1.96051972
73	Sloping forehead (HP:0000340)	1.95514639
74	Hypoplasia of the pons (HP:0012110)	1.95277306
75	Lactic acidosis (HP:0003128)	1.93637554
76	Cerebral hypomyelination (HP:0006808)	1.93051140
77	Abnormality of alanine metabolism (HP:0010916)	1.91017189
78	Hyperalaninemia (HP:0003348)	1.91017189
79	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.91017189
80	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.87729656
81	Abnormal protein N-linked glycosylation (HP:0012347)	1.87729656
82	Abnormal protein glycosylation (HP:0012346)	1.87729656
83	Abnormal glycosylation (HP:0012345)	1.87729656
84	Renal Fanconi syndrome (HP:0001994)	1.86414778
85	Horseshoe kidney (HP:0000085)	1.85301411
86	Preaxial hand polydactyly (HP:0001177)	1.85149175
87	Poor coordination (HP:0002370)	1.84725097
88	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.82815376
89	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.82815376
90	Abnormality of the pons (HP:0007361)	1.80200502
91	Lethargy (HP:0001254)	1.79331184
92	Small intestinal stenosis (HP:0012848)	1.78665922
93	Duodenal stenosis (HP:0100867)	1.78665922
94	Type 2 muscle fiber atrophy (HP:0003554)	1.78373876
95	Ependymoma (HP:0002888)	1.78299273
96	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.77022251
97	Sclerocornea (HP:0000647)	1.75398678
98	Postaxial foot polydactyly (HP:0001830)	1.75328006
99	Abnormality of cochlea (HP:0000375)	1.74251359
100	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.73690509

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BUB1	4.06470314
2	VRK2	3.70732365
3	ZAK	3.59443063
4	CDC7	3.30052994
5	TSSK6	3.07102062
6	MST4	2.71249884
7	SRPK1	2.56262063
8	TTK	2.55320312
9	MKNK1	2.48277232
10	PLK4	2.27854939
11	WEE1	2.21720815
12	TRIM28	2.18680570
13	PBK	2.15794818
14	PLK3	2.13432532
15	MKNK2	2.12167025
16	NEK1	2.10908873
17	NME1	2.10653118
18	PASK	2.04023907
19	STK16	2.00795889
20	NUAK1	2.00757842
21	EIF2AK3	2.00591932
22	VRK1	1.96724066
23	EIF2AK1	1.85525955
24	TNIK	1.66852236
25	TAF1	1.63895595
26	WNK3	1.63714039
27	DYRK3	1.59726581
28	PLK1	1.51667028
29	PRKCI	1.49681047
30	BRSK2	1.43007451
31	TLK1	1.39966861
32	ATR	1.38853209
33	CHEK2	1.37551065
34	BMPR1B	1.31548492
35	ARAF	1.21508583
36	PNCK	1.19341969
37	AURKB	1.15040007
38	CDK19	1.06086001
39	NME2	1.05150363
40	RPS6KB2	1.03070258
41	EPHA2	1.01672582
42	PIM2	0.98316128
43	GRK1	0.96825006
44	IRAK1	0.95265863
45	BCKDK	0.95212934
46	MAP4K2	0.94846298
47	BRAF	0.93473021
48	MAPK15	0.87366558
49	EIF2AK2	0.86424178
50	CDK8	0.77451056
51	MAP3K10	0.77188970
52	CHEK1	0.76177636
53	PAK4	0.75684373
54	CDK7	0.74194705
55	SMG1	0.74006643
56	DYRK2	0.73250086
57	STK4	0.71373419
58	MAP2K7	0.71156700
59	ERBB4	0.70743884
60	ADRBK2	0.69997590
61	NEK2	0.69391957
62	MAPKAPK3	0.67377751
63	DAPK1	0.66483882
64	ATM	0.65707848
65	FGFR2	0.65490279
66	RPS6KA5	0.65401042
67	CSNK1G3	0.64558841
68	TIE1	0.64164727
69	CSNK2A2	0.63760521
70	CSNK1G1	0.62262014
71	FLT3	0.59254186
72	RIPK1	0.58591005
73	BRSK1	0.58564263
74	PLK2	0.58317405
75	MAPKAPK5	0.57039264
76	AURKA	0.56222654
77	CSNK2A1	0.55665606
78	MAP3K4	0.54777572
79	TEC	0.53050442
80	TGFBR1	0.52211485
81	ALK	0.51856214
82	CDK3	0.51067287
83	PRKCG	0.50603065
84	STK38L	0.49057308
85	CSNK1G2	0.46525661
86	STK3	0.46002752
87	RPS6KA4	0.44843610
88	FGFR1	0.44442592
89	TESK2	0.43562735
90	CSNK1A1L	0.43519112
91	CDK2	0.40444374
92	MUSK	0.38487625
93	OXSR1	0.37263123
94	DAPK3	0.36591747
95	CDK1	0.35896975
96	CSNK1E	0.33794948
97	RAF1	0.29469749
98	BCR	0.28063750
99	AKT2	0.27195881
100	PDK2	0.26553017

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	3.73310498
2	Ribosome_Homo sapiens_hsa03010	3.59991670
3	Mismatch repair_Homo sapiens_hsa03430	3.49922082
4	Proteasome_Homo sapiens_hsa03050	3.25947553
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.19759950
6	Homologous recombination_Homo sapiens_hsa03440	2.99479969
7	RNA polymerase_Homo sapiens_hsa03020	2.88635871
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.60053199
9	Base excision repair_Homo sapiens_hsa03410	2.57620587
10	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.54679430
11	Protein export_Homo sapiens_hsa03060	2.44228627
12	One carbon pool by folate_Homo sapiens_hsa00670	2.37923276
13	RNA transport_Homo sapiens_hsa03013	2.21165681
14	Nucleotide excision repair_Homo sapiens_hsa03420	2.20079690
15	Spliceosome_Homo sapiens_hsa03040	2.19213476
16	Fanconi anemia pathway_Homo sapiens_hsa03460	2.17692573
17	Oxidative phosphorylation_Homo sapiens_hsa00190	2.13786112
18	Parkinsons disease_Homo sapiens_hsa05012	2.03987047
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.87324353
20	Basal transcription factors_Homo sapiens_hsa03022	1.84732934
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.84452217
22	RNA degradation_Homo sapiens_hsa03018	1.80082704
23	Huntingtons disease_Homo sapiens_hsa05016	1.71420809
24	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.61918452
25	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.56937108
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.54209435
27	Cell cycle_Homo sapiens_hsa04110	1.51311584
28	Sulfur relay system_Homo sapiens_hsa04122	1.44489687
29	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.43940933
30	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.43547629
31	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.39726557
32	Propanoate metabolism_Homo sapiens_hsa00640	1.34674010
33	Purine metabolism_Homo sapiens_hsa00230	1.34498974
34	Glutathione metabolism_Homo sapiens_hsa00480	1.32155581
35	Fatty acid elongation_Homo sapiens_hsa00062	1.21340314
36	Pyruvate metabolism_Homo sapiens_hsa00620	1.21248367
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.20526365
38	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.16397976
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.14851092
40	Folate biosynthesis_Homo sapiens_hsa00790	1.10433281
41	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.07176523
42	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.01790476
43	Alzheimers disease_Homo sapiens_hsa05010	1.00548645
44	Steroid biosynthesis_Homo sapiens_hsa00100	0.98830504
45	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.96371243
46	mRNA surveillance pathway_Homo sapiens_hsa03015	0.94897492
47	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.89630921
48	p53 signaling pathway_Homo sapiens_hsa04115	0.85378595
49	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.80703950
50	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.80412248
51	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.78005346
52	Metabolic pathways_Homo sapiens_hsa01100	0.75194134
53	Carbon metabolism_Homo sapiens_hsa01200	0.70956267
54	Fatty acid metabolism_Homo sapiens_hsa01212	0.70784520
55	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.67792431
56	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65292534
57	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.63481200
58	Peroxisome_Homo sapiens_hsa04146	0.61421211
59	Lysine degradation_Homo sapiens_hsa00310	0.61398646
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.60909828
61	Phototransduction_Homo sapiens_hsa04744	0.60085569
62	Basal cell carcinoma_Homo sapiens_hsa05217	0.59917016
63	Regulation of autophagy_Homo sapiens_hsa04140	0.59866870
64	Tyrosine metabolism_Homo sapiens_hsa00350	0.59106923
65	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.58954173
66	Butanoate metabolism_Homo sapiens_hsa00650	0.58350774
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56783316
68	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.51770334
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50622767
70	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.48497534
71	Tryptophan metabolism_Homo sapiens_hsa00380	0.46408722
72	Oocyte meiosis_Homo sapiens_hsa04114	0.44771940
73	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.39149495
74	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37620554
75	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.36995630
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.36949858
77	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.36224268
78	Cardiac muscle contraction_Homo sapiens_hsa04260	0.35584250
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.34452703
80	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.32914218
81	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.32784823
82	Sulfur metabolism_Homo sapiens_hsa00920	0.32615146
83	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.31116570
84	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.29527707
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.28511546
86	Arginine and proline metabolism_Homo sapiens_hsa00330	0.27695614
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.26965096
88	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.26249669
89	Thyroid cancer_Homo sapiens_hsa05216	0.25322471
90	Alcoholism_Homo sapiens_hsa05034	0.23947285
91	Hippo signaling pathway_Homo sapiens_hsa04390	0.23797922
92	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.23672820
93	Fatty acid degradation_Homo sapiens_hsa00071	0.23222681
94	Pentose phosphate pathway_Homo sapiens_hsa00030	0.22830620
95	Wnt signaling pathway_Homo sapiens_hsa04310	0.22699969
96	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.21796979
97	Retinol metabolism_Homo sapiens_hsa00830	0.21248247
98	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.18583629
99	Olfactory transduction_Homo sapiens_hsa04740	0.16293212
100	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.15117461

FAM86C2P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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