ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	4.10422534
2	peptidyl-histidine modification (GO:0018202)	3.86911744
3	rRNA modification (GO:0000154)	3.85447744
4	proteasome assembly (GO:0043248)	3.84377909
5	DNA replication checkpoint (GO:0000076)	3.80286859
6	regulation of mitochondrial translation (GO:0070129)	3.61716403
7	rRNA methylation (GO:0031167)	3.51777327
8	mitochondrial RNA metabolic process (GO:0000959)	3.48499682
9	meiotic chromosome segregation (GO:0045132)	3.43170974
10	pseudouridine synthesis (GO:0001522)	3.42895107
11	tRNA methylation (GO:0030488)	3.42834251
12	termination of RNA polymerase III transcription (GO:0006386)	3.36656250
13	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.36656250
14	ribosome assembly (GO:0042255)	3.25876573
15	respiratory chain complex IV assembly (GO:0008535)	3.25140274
16	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.24284188
17	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.24284188
18	ribosome biogenesis (GO:0042254)	3.24263797
19	cullin deneddylation (GO:0010388)	3.21326616
20	metallo-sulfur cluster assembly (GO:0031163)	3.16811039
21	iron-sulfur cluster assembly (GO:0016226)	3.16811039
22	maturation of 5.8S rRNA (GO:0000460)	3.14116440
23	tRNA modification (GO:0006400)	3.10887585
24	protein deneddylation (GO:0000338)	3.07815240
25	IMP biosynthetic process (GO:0006188)	3.06481830
26	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.05167417
27	NADH dehydrogenase complex assembly (GO:0010257)	3.05167417
28	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.05167417
29	formation of translation preinitiation complex (GO:0001731)	3.03090803
30	transcription from mitochondrial promoter (GO:0006390)	3.02664048
31	DNA strand elongation involved in DNA replication (GO:0006271)	3.01548704
32	nucleobase biosynthetic process (GO:0046112)	3.01419056
33	tRNA processing (GO:0008033)	3.00922294
34	DNA damage response, detection of DNA damage (GO:0042769)	3.00547033
35	tRNA metabolic process (GO:0006399)	3.00175163
36	amino acid activation (GO:0043038)	3.00148675
37	tRNA aminoacylation (GO:0043039)	3.00148675
38	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.99388105
39	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.99030153
40	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.99030153
41	protein complex biogenesis (GO:0070271)	2.98187695
42	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.97874927
43	DNA catabolic process, exonucleolytic (GO:0000738)	2.96352382
44	tRNA aminoacylation for protein translation (GO:0006418)	2.96266072
45	DNA strand elongation (GO:0022616)	2.96092556
46	DNA replication-dependent nucleosome organization (GO:0034723)	2.95610377
47	DNA replication-dependent nucleosome assembly (GO:0006335)	2.95610377
48	telomere maintenance via semi-conservative replication (GO:0032201)	2.93563427
49	mitochondrial respiratory chain complex assembly (GO:0033108)	2.89325463
50	ncRNA 3-end processing (GO:0043628)	2.84763866
51	L-serine metabolic process (GO:0006563)	2.84685254
52	purine nucleobase biosynthetic process (GO:0009113)	2.83132126
53	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.82032071
54	mitochondrial DNA replication (GO:0006264)	2.82001630
55	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.81993458
56	lipopolysaccharide biosynthetic process (GO:0009103)	2.81205747
57	mannosylation (GO:0097502)	2.77907578
58	DNA replication initiation (GO:0006270)	2.74087818
59	cytochrome complex assembly (GO:0017004)	2.73788401
60	establishment of integrated proviral latency (GO:0075713)	2.73425538
61	regulation of translational fidelity (GO:0006450)	2.71273200
62	ubiquinone biosynthetic process (GO:0006744)	2.68489131
63	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.67282953
64	negative regulation of ligase activity (GO:0051352)	2.67282953
65	viral mRNA export from host cell nucleus (GO:0046784)	2.64266281
66	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.64266182
67	protein targeting to mitochondrion (GO:0006626)	2.64204606
68	folic acid-containing compound biosynthetic process (GO:0009396)	2.63323967
69	chromatin remodeling at centromere (GO:0031055)	2.62573716
70	ncRNA processing (GO:0034470)	2.62558059
71	DNA strand renaturation (GO:0000733)	2.60984079
72	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.60089018
73	mitochondrial DNA metabolic process (GO:0032042)	2.59763870
74	cellular component biogenesis (GO:0044085)	2.59086755
75	replication fork processing (GO:0031297)	2.58549695
76	rRNA processing (GO:0006364)	2.58367911
77	CENP-A containing nucleosome assembly (GO:0034080)	2.57178002
78	ncRNA metabolic process (GO:0034660)	2.56784800
79	response to X-ray (GO:0010165)	2.56475813
80	protein K6-linked ubiquitination (GO:0085020)	2.56474411
81	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.55183674
82	transcription-coupled nucleotide-excision repair (GO:0006283)	2.54829760
83	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.53661546
84	telomere maintenance via recombination (GO:0000722)	2.52323061
85	ribonucleoprotein complex biogenesis (GO:0022613)	2.51819451
86	termination of RNA polymerase I transcription (GO:0006363)	2.50613090
87	GMP metabolic process (GO:0046037)	2.48820128
88	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.48271569
89	spliceosomal snRNP assembly (GO:0000387)	2.47609325
90	IMP metabolic process (GO:0046040)	2.47559864
91	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.46421699
92	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.45862637
93	rRNA metabolic process (GO:0016072)	2.45295747
94	mitotic recombination (GO:0006312)	2.45084308
95	protein maturation by protein folding (GO:0022417)	2.43657321
96	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.43122000
97	double-strand break repair via nonhomologous end joining (GO:0006303)	2.41179321
98	non-recombinational repair (GO:0000726)	2.41179321
99	platelet dense granule organization (GO:0060155)	2.39781595
100	protein neddylation (GO:0045116)	2.39489756

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.44011458
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.40677544
3	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	4.36112544
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.93747805
5	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.57774016
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.54727273
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.46566864
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.19234868
9	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.06597936
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.03496958
11	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.97140291
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.84946878
13	GABP_19822575_ChIP-Seq_HepG2_Human	2.82710502
14	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.81247701
15	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.73911238
16	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.71472070
17	DCP1A_22483619_ChIP-Seq_HELA_Human	2.71041326
18	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.65807585
19	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.65601730
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.50956652
21	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.50545009
22	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.49413132
23	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.38785456
24	VDR_23849224_ChIP-Seq_CD4+_Human	2.38353857
25	XRN2_22483619_ChIP-Seq_HELA_Human	2.37854905
26	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.33858931
27	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.25073108
28	FOXP3_21729870_ChIP-Seq_TREG_Human	2.24495407
29	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.17648877
30	ELK1_19687146_ChIP-ChIP_HELA_Human	2.14523415
31	TTF2_22483619_ChIP-Seq_HELA_Human	2.05567234
32	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	2.00247008
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.97212380
34	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.91328244
35	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.91308574
36	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.89272411
37	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.89187259
38	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.85528434
39	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.80664313
40	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.77638096
41	KDM5A_27292631_Chip-Seq_BREAST_Human	1.77069485
42	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.72434647
43	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.69165481
44	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.68881415
45	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.68174052
46	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.66607273
47	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.62725442
48	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.62668312
49	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.60244359
50	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.55683471
51	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.55571551
52	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.49916253
53	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.48515553
54	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.48167697
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.45014928
56	AR_21909140_ChIP-Seq_LNCAP_Human	1.38244610
57	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.35456208
58	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.32379077
59	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.32016243
60	ZNF274_21170338_ChIP-Seq_K562_Hela	1.31444196
61	CIITA_25753668_ChIP-Seq_RAJI_Human	1.28497349
62	TFEB_21752829_ChIP-Seq_HELA_Human	1.27791670
63	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.26032995
64	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.25358295
65	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.25279515
66	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.23502852
67	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.20720175
68	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.16743779
69	* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.14884504
70	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.14542647
71	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.13452936
72	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.13073950
73	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.12894398
74	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.09220487
75	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.08571673
76	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.07801114
77	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.04136759
78	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.03321338
79	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.00234984
80	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.97580704
81	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.95614039
82	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.94815965
83	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.94387596
84	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.94205316
85	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.93520488
86	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.92749899
87	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.92524952
88	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.92348945
89	EWS_26573619_Chip-Seq_HEK293_Human	0.91543549
90	ZNF263_19887448_ChIP-Seq_K562_Human	0.89237446
91	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.83429380
92	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.83119673
93	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.80036148
94	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.79635911
95	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.79365067
96	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.79336224
97	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.77886753
98	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.76661920
99	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	0.76567753
100	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.76537936

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	4.09174163
2	MP0010094_abnormal_chromosome_stability	3.21454625
3	MP0008058_abnormal_DNA_repair	3.03577595
4	MP0003136_yellow_coat_color	2.99670991
5	MP0003111_abnormal_nucleus_morphology	2.97350363
6	MP0000372_irregular_coat_pigmentation	2.83194860
7	MP0003693_abnormal_embryo_hatching	2.68823782
8	MP0010030_abnormal_orbit_morphology	2.53636779
9	MP0004957_abnormal_blastocyst_morpholog	2.24468339
10	MP0003786_premature_aging	2.22688843
11	MP0008932_abnormal_embryonic_tissue	2.22644856
12	MP0002938_white_spotting	2.20246270
13	MP0003077_abnormal_cell_cycle	2.13011314
14	MP0009697_abnormal_copulation	2.00403619
15	MP0008007_abnormal_cellular_replicative	1.98815534
16	MP0005257_abnormal_intraocular_pressure	1.94793425
17	MP0000358_abnormal_cell_content/	1.83630585
18	MP0002877_abnormal_melanocyte_morpholog	1.80527557
19	MP0008438_abnormal_cutaneous_collagen	1.77610982
20	MP0008057_abnormal_DNA_replication	1.76731125
21	MP0003718_maternal_effect	1.73360806
22	MP0008789_abnormal_olfactory_epithelium	1.72741256
23	MP0000015_abnormal_ear_pigmentation	1.71923886
24	MP0005623_abnormal_meninges_morphology	1.67920167
25	MP0003806_abnormal_nucleotide_metabolis	1.66492764
26	MP0005408_hypopigmentation	1.48719549
27	MP0001661_extended_life_span	1.42218063
28	MP0005075_abnormal_melanosome_morpholog	1.36135756
29	MP0006292_abnormal_olfactory_placode	1.35963591
30	MP0005174_abnormal_tail_pigmentation	1.35370382
31	MP0001324_abnormal_eye_pigmentation	1.35114715
32	MP0006035_abnormal_mitochondrial_morpho	1.34739493
33	MP0004272_abnormal_basement_membrane	1.33843392
34	MP0003937_abnormal_limbs/digits/tail_de	1.33163374
35	MP0005499_abnormal_olfactory_system	1.30234192
36	MP0005394_taste/olfaction_phenotype	1.30234192
37	MP0003186_abnormal_redox_activity	1.26984419
38	MP0000049_abnormal_middle_ear	1.26268969
39	MP0001293_anophthalmia	1.21440913
40	MP0003385_abnormal_body_wall	1.18701905
41	MP0009384_cardiac_valve_regurgitation	1.18068078
42	MP0001529_abnormal_vocalization	1.16097367
43	MP0004147_increased_porphyrin_level	1.14164180
44	MP0006072_abnormal_retinal_apoptosis	1.14136058
45	MP0002234_abnormal_pharynx_morphology	1.12406074
46	MP0000371_diluted_coat_color	1.11698370
47	MP0001542_abnormal_bone_strength	1.11665128
48	MP0002090_abnormal_vision	1.10699203
49	MP0000749_muscle_degeneration	1.10038876
50	MP0006036_abnormal_mitochondrial_physio	1.09885927
51	MP0004197_abnormal_fetal_growth/weight/	1.08215819
52	MP0000751_myopathy	1.07590119
53	MP0005508_abnormal_skeleton_morphology	1.05446544
54	MP0002075_abnormal_coat/hair_pigmentati	1.04502294
55	MP0009250_abnormal_appendicular_skeleto	1.03702793
56	MP0002160_abnormal_reproductive_system	1.03172581
57	MP0005253_abnormal_eye_physiology	0.99188720
58	MP0002233_abnormal_nose_morphology	0.98533600
59	MP0002095_abnormal_skin_pigmentation	0.97730736
60	MP0003755_abnormal_palate_morphology	0.97383863
61	MP0002085_abnormal_embryonic_tissue	0.95811607
62	MP0005391_vision/eye_phenotype	0.94776334
63	MP0001697_abnormal_embryo_size	0.93896488
64	MP0002084_abnormal_developmental_patter	0.93873860
65	MP0002177_abnormal_outer_ear	0.93300804
66	MP0002080_prenatal_lethality	0.93219063
67	MP0005380_embryogenesis_phenotype	0.91101794
68	MP0001672_abnormal_embryogenesis/_devel	0.91101794
69	MP0002751_abnormal_autonomic_nervous	0.90822756
70	MP0002111_abnormal_tail_morphology	0.88638870
71	MP0002210_abnormal_sex_determination	0.88608972
72	MP0003942_abnormal_urinary_system	0.88533661
73	MP0005083_abnormal_biliary_tract	0.87769115
74	MP0010368_abnormal_lymphatic_system	0.87553144
75	MP0004858_abnormal_nervous_system	0.86989581
76	MP0002653_abnormal_ependyma_morphology	0.86166788
77	MP0002282_abnormal_trachea_morphology	0.85477785
78	MP0002932_abnormal_joint_morphology	0.85227791
79	MP0003941_abnormal_skin_development	0.84980949
80	MP0000350_abnormal_cell_proliferation	0.84941333
81	MP0010307_abnormal_tumor_latency	0.84006603
82	MP0004133_heterotaxia	0.83681299
83	MP0008995_early_reproductive_senescence	0.82427360
84	MP0001186_pigmentation_phenotype	0.81058700
85	MP0005551_abnormal_eye_electrophysiolog	0.79509975
86	MP0002092_abnormal_eye_morphology	0.78836937
87	MP0005384_cellular_phenotype	0.77738694
88	MP0001299_abnormal_eye_distance/	0.77725381
89	MP0005197_abnormal_uvea_morphology	0.77638271
90	MP0000428_abnormal_craniofacial_morphol	0.77107689
91	MP0005503_abnormal_tendon_morphology	0.76923915
92	MP0005501_abnormal_skin_physiology	0.76579578
93	MP0003950_abnormal_plasma_membrane	0.76530987
94	MP0009053_abnormal_anal_canal	0.75500368
95	MP0001849_ear_inflammation	0.73541918
96	MP0008875_abnormal_xenobiotic_pharmacok	0.72513661
97	MP0001730_embryonic_growth_arrest	0.71834278
98	MP0001270_distended_abdomen	0.71484656
99	MP0002114_abnormal_axial_skeleton	0.70129664
100	MP0000750_abnormal_muscle_regeneration	0.69666633

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type I transferrin isoform profile (HP:0003642)	3.33295390
2	Abnormal protein glycosylation (HP:0012346)	3.19662461
3	Abnormal glycosylation (HP:0012345)	3.19662461
4	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.19662461
5	Abnormal protein N-linked glycosylation (HP:0012347)	3.19662461
6	Hepatocellular necrosis (HP:0001404)	2.83042510
7	Reduced antithrombin III activity (HP:0001976)	2.81341088
8	Abnormality of the umbilical cord (HP:0010881)	2.75365084
9	Renal Fanconi syndrome (HP:0001994)	2.68484304
10	Increased CSF lactate (HP:0002490)	2.65612026
11	Ependymoma (HP:0002888)	2.65113755
12	Rib fusion (HP:0000902)	2.59800254
13	Entropion (HP:0000621)	2.58982850
14	Increased hepatocellular lipid droplets (HP:0006565)	2.55498837
15	Mitochondrial inheritance (HP:0001427)	2.55203121
16	Lipid accumulation in hepatocytes (HP:0006561)	2.52092954
17	Increased serum lactate (HP:0002151)	2.46636943
18	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.43558909
19	Squamous cell carcinoma (HP:0002860)	2.36350637
20	Hepatic necrosis (HP:0002605)	2.35455178
21	Microvesicular hepatic steatosis (HP:0001414)	2.35397377
22	Type II lissencephaly (HP:0007260)	2.34337375
23	Abnormality of the fetal cardiovascular system (HP:0010948)	2.33385641
24	Abnormal umbilical cord blood vessels (HP:0011403)	2.33385641
25	Single umbilical artery (HP:0001195)	2.33385641
26	Premature rupture of membranes (HP:0001788)	2.30129346
27	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.28242909
28	Hyperglycinemia (HP:0002154)	2.25899481
29	Testicular atrophy (HP:0000029)	2.25228357
30	Retinal dysplasia (HP:0007973)	2.24170086
31	Upper limb muscle weakness (HP:0003484)	2.21859936
32	Abnormality of the ileum (HP:0001549)	2.20355771
33	Acute encephalopathy (HP:0006846)	2.19112499
34	Cerebellar dysplasia (HP:0007033)	2.18092161
35	Rough bone trabeculation (HP:0100670)	2.17952879
36	Vertebral compression fractures (HP:0002953)	2.17445016
37	Poikiloderma (HP:0001029)	2.14684696
38	Acute necrotizing encephalopathy (HP:0006965)	2.13475732
39	Birth length less than 3rd percentile (HP:0003561)	2.08866169
40	Meckel diverticulum (HP:0002245)	2.07999995
41	Adrenal hypoplasia (HP:0000835)	2.07226583
42	Abnormal mitochondria in muscle tissue (HP:0008316)	2.06236692
43	Chromsome breakage (HP:0040012)	2.05970946
44	Pancreatic fibrosis (HP:0100732)	2.05054687
45	Abnormality of the astrocytes (HP:0100707)	2.03311722
46	Astrocytoma (HP:0009592)	2.03311722
47	Abnormal number of incisors (HP:0011064)	2.03188484
48	Molar tooth sign on MRI (HP:0002419)	2.02324361
49	Abnormality of midbrain morphology (HP:0002418)	2.02324361
50	Lactic acidosis (HP:0003128)	1.98458896
51	Opisthotonus (HP:0002179)	1.96253675
52	Generalized amyotrophy (HP:0003700)	1.93576452
53	Patellar aplasia (HP:0006443)	1.92843527
54	Redundant skin (HP:0001582)	1.92088634
55	Abnormalities of placenta or umbilical cord (HP:0001194)	1.92013564
56	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.91137478
57	Poor head control (HP:0002421)	1.91008227
58	Aplasia/Hypoplasia of the patella (HP:0006498)	1.87730758
59	Abnormal trabecular bone morphology (HP:0100671)	1.86099575
60	Abnormality of alanine metabolism (HP:0010916)	1.85770218
61	Hyperalaninemia (HP:0003348)	1.85770218
62	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.85770218
63	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.84138637
64	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.84138637
65	Absent thumb (HP:0009777)	1.83333552
66	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.82813091
67	Absent epiphyses (HP:0010577)	1.82813091
68	White forelock (HP:0002211)	1.82420971
69	Hypoplasia of the pons (HP:0012110)	1.81529200
70	True hermaphroditism (HP:0010459)	1.78700080
71	Patchy hypopigmentation of hair (HP:0011365)	1.77725570
72	Dyschromatopsia (HP:0007641)	1.77381110
73	Exercise intolerance (HP:0003546)	1.76911419
74	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.75774908
75	Sclerocornea (HP:0000647)	1.75567724
76	Ectopic kidney (HP:0000086)	1.75400697
77	Cutaneous melanoma (HP:0012056)	1.71382644
78	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.69780279
79	Pancreatic cysts (HP:0001737)	1.69262090
80	Premature graying of hair (HP:0002216)	1.69228189
81	Abnormal number of erythroid precursors (HP:0012131)	1.68941014
82	Absent radius (HP:0003974)	1.68821583
83	Aplastic anemia (HP:0001915)	1.68023992
84	Exertional dyspnea (HP:0002875)	1.66502036
85	Progressive microcephaly (HP:0000253)	1.66089080
86	Cerebral hypomyelination (HP:0006808)	1.65608125
87	Attenuation of retinal blood vessels (HP:0007843)	1.65481165
88	Increased intramyocellular lipid droplets (HP:0012240)	1.65420053
89	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.64697490
90	Slender long bone (HP:0003100)	1.64364115
91	Mesangial abnormality (HP:0001966)	1.64343730
92	Disproportionate short-trunk short stature (HP:0003521)	1.62128866
93	Intestinal atresia (HP:0011100)	1.62027742
94	3-Methylglutaconic aciduria (HP:0003535)	1.60955030
95	Glioma (HP:0009733)	1.60612119
96	Sloping forehead (HP:0000340)	1.59612159
97	Abnormality of the pons (HP:0007361)	1.58750595
98	Colon cancer (HP:0003003)	1.58447114
99	Aplasia/hypoplasia of the humerus (HP:0006507)	1.58117316
100	Pancytopenia (HP:0001876)	1.58009458

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.43940283
2	NME2	3.19213236
3	MUSK	3.03564013
4	BUB1	2.89741552
5	STK16	2.64395461
6	LIMK1	2.60499886
7	PIM2	2.43523278
8	CDC7	2.40955046
9	NUAK1	2.30277491
10	EIF2AK3	2.28946426
11	TRIM28	2.26503943
12	ZAK	2.16664746
13	NEK1	2.11060362
14	PBK	2.06664131
15	EIF2AK1	1.98087359
16	SRPK1	1.67536023
17	TTK	1.63108874
18	CDK8	1.61318722
19	ERBB4	1.61284040
20	LATS1	1.55803572
21	CCNB1	1.54644306
22	TSSK6	1.48572817
23	MST4	1.47551432
24	FLT3	1.46623720
25	CSNK1A1L	1.43611183
26	CSNK1G3	1.43412990
27	PLK1	1.38330966
28	ATR	1.34827745
29	KDR	1.30851968
30	BMPR1B	1.30734564
31	MKNK1	1.27587312
32	PRKD3	1.26983312
33	MAP4K2	1.26912435
34	SIK3	1.26812173
35	ACVR1B	1.26679506
36	CHEK2	1.24983002
37	BCKDK	1.18374503
38	INSRR	1.18164114
39	TESK1	1.16695981
40	MKNK2	1.12776387
41	WEE1	1.12730406
42	PLK3	1.11607312
43	VRK1	1.08753382
44	TLK1	1.08578401
45	CSNK1G2	1.07799405
46	BCR	1.07727055
47	PAK4	1.07281156
48	ERBB3	1.06617343
49	CSNK1G1	1.05014922
50	NEK2	0.99578053
51	IRAK3	0.99156311
52	ADRBK2	0.96944536
53	STK38L	0.93870864
54	STK3	0.93779591
55	PLK4	0.93373433
56	CDK7	0.92996790
57	BRSK2	0.91299954
58	TESK2	0.86609374
59	BRSK1	0.82520094
60	MAPKAPK3	0.80928636
61	ABL2	0.79397004
62	DAPK1	0.78845453
63	WNK3	0.78454314
64	PDK2	0.78014224
65	MYLK	0.77049217
66	TAOK2	0.76160008
67	CHEK1	0.75948407
68	EPHA2	0.74360463
69	AURKA	0.74245915
70	PAK1	0.73808352
71	MST1R	0.72768070
72	MAP2K7	0.71535508
73	AURKB	0.69732880
74	PRKCI	0.69696580
75	MET	0.69341488
76	RPS6KA5	0.66808596
77	PAK2	0.65597177
78	PTK2	0.65152152
79	RPS6KA4	0.64826814
80	ARAF	0.64571798
81	ADRBK1	0.64558982
82	DYRK3	0.63566233
83	FRK	0.62462928
84	ATM	0.61804858
85	PRKD2	0.57367575
86	GRK1	0.56729427
87	AKT2	0.56519615
88	TGFBR1	0.55101518
89	MELK	0.50480762
90	MARK3	0.50092997
91	PKN2	0.48812719
92	ILK	0.47705626
93	PLK2	0.43491092
94	PINK1	0.43099099
95	CLK1	0.42320218
96	MAPK11	0.41736653
97	CSNK2A1	0.40009595
98	STK38	0.36761089
99	MAP3K8	0.33490124
100	STK4	0.33450756

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	RNA polymerase_Homo sapiens_hsa03020	3.21250794
2	DNA replication_Homo sapiens_hsa03030	3.13202443
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.92905014
4	Proteasome_Homo sapiens_hsa03050	2.91569142
5	Sulfur relay system_Homo sapiens_hsa04122	2.77562731
6	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.73466066
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.46047065
8	Base excision repair_Homo sapiens_hsa03410	2.46019156
9	Mismatch repair_Homo sapiens_hsa03430	2.45135950
10	Homologous recombination_Homo sapiens_hsa03440	2.35124527
11	One carbon pool by folate_Homo sapiens_hsa00670	2.31221656
12	Pyrimidine metabolism_Homo sapiens_hsa00240	2.25159893
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.15900862
14	Non-homologous end-joining_Homo sapiens_hsa03450	2.13481763
15	Nucleotide excision repair_Homo sapiens_hsa03420	2.01278405
16	Basal transcription factors_Homo sapiens_hsa03022	1.97779077
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.94177298
18	Protein export_Homo sapiens_hsa03060	1.93631362
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.85724354
20	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.81311675
21	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.79216975
22	RNA transport_Homo sapiens_hsa03013	1.71176740
23	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.48797945
24	RNA degradation_Homo sapiens_hsa03018	1.46218712
25	Cell cycle_Homo sapiens_hsa04110	1.45998698
26	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.45992503
27	Oxidative phosphorylation_Homo sapiens_hsa00190	1.44861478
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.44738993
29	Spliceosome_Homo sapiens_hsa03040	1.43776412
30	Fatty acid elongation_Homo sapiens_hsa00062	1.42615477
31	Purine metabolism_Homo sapiens_hsa00230	1.40678841
32	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.39203212
33	Steroid biosynthesis_Homo sapiens_hsa00100	1.36936623
34	Selenocompound metabolism_Homo sapiens_hsa00450	1.36063242
35	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.31631824
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.31537324
37	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.28238836
38	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.25655039
39	Huntingtons disease_Homo sapiens_hsa05016	1.24725205
40	Glutathione metabolism_Homo sapiens_hsa00480	1.24554043
41	Parkinsons disease_Homo sapiens_hsa05012	1.20008127
42	Propanoate metabolism_Homo sapiens_hsa00640	1.16325612
43	Ribosome_Homo sapiens_hsa03010	1.10966819
44	Folate biosynthesis_Homo sapiens_hsa00790	1.05527806
45	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.03518713
46	p53 signaling pathway_Homo sapiens_hsa04115	1.00266191
47	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.99691111
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.99523522
49	Sulfur metabolism_Homo sapiens_hsa00920	0.97088989
50	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.94813103
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.92452500
52	Lysine degradation_Homo sapiens_hsa00310	0.88928281
53	Pyruvate metabolism_Homo sapiens_hsa00620	0.88458197
54	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.87526940
55	Metabolic pathways_Homo sapiens_hsa01100	0.83810020
56	Carbon metabolism_Homo sapiens_hsa01200	0.79976302
57	mRNA surveillance pathway_Homo sapiens_hsa03015	0.77720713
58	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.76244867
59	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.74430674
60	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.72555629
61	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.72121423
62	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.71761606
63	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.71015206
64	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.67732987
65	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.67618571
66	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.66479549
67	Basal cell carcinoma_Homo sapiens_hsa05217	0.64813378
68	Hippo signaling pathway_Homo sapiens_hsa04390	0.64632588
69	Alzheimers disease_Homo sapiens_hsa05010	0.62802565
70	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.61608657
71	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.60317993
72	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.60268840
73	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.51758461
74	Peroxisome_Homo sapiens_hsa04146	0.50398438
75	Galactose metabolism_Homo sapiens_hsa00052	0.48751885
76	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.47369619
77	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.46507084
78	Butanoate metabolism_Homo sapiens_hsa00650	0.46044255
79	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.43259628
80	Sphingolipid metabolism_Homo sapiens_hsa00600	0.42604322
81	Lysosome_Homo sapiens_hsa04142	0.42370171
82	Oocyte meiosis_Homo sapiens_hsa04114	0.39444684
83	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.36565298
84	Pentose phosphate pathway_Homo sapiens_hsa00030	0.36474484
85	Arginine and proline metabolism_Homo sapiens_hsa00330	0.35499333
86	Fatty acid metabolism_Homo sapiens_hsa01212	0.34812321
87	Melanoma_Homo sapiens_hsa05218	0.33741832
88	Wnt signaling pathway_Homo sapiens_hsa04310	0.31279845
89	ECM-receptor interaction_Homo sapiens_hsa04512	0.31215166
90	Vibrio cholerae infection_Homo sapiens_hsa05110	0.30611412
91	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.30580048
92	Other glycan degradation_Homo sapiens_hsa00511	0.28739770
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.25464348
94	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.24501334
95	Tyrosine metabolism_Homo sapiens_hsa00350	0.24410837
96	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.24120045
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.23593237
98	Bladder cancer_Homo sapiens_hsa05219	0.22921864
99	Phototransduction_Homo sapiens_hsa04744	0.22916466
100	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.21521842

FAM86DP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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