ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	peptidyl-histidine modification (GO:0018202)	5.72794839
2	establishment of mitochondrion localization (GO:0051654)	4.73305934
3	mitochondrion transport along microtubule (GO:0047497)	4.66013703
4	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	4.66013703
5	GTP biosynthetic process (GO:0006183)	4.60604465
6	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.44600980
7	pyrimidine nucleotide catabolic process (GO:0006244)	4.05421988
8	UTP biosynthetic process (GO:0006228)	4.05352558
9	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.97737527
10	NADH dehydrogenase complex assembly (GO:0010257)	3.97737527
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.97737527
12	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.94848682
13	UTP metabolic process (GO:0046051)	3.93086618
14	auditory receptor cell stereocilium organization (GO:0060088)	3.77342227
15	branched-chain amino acid catabolic process (GO:0009083)	3.76275729
16	coenzyme catabolic process (GO:0009109)	3.74408831
17	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	3.73036728
18	peptidyl-arginine omega-N-methylation (GO:0035247)	3.62578434
19	aggressive behavior (GO:0002118)	3.60658538
20	multicellular organism reproduction (GO:0032504)	3.55313683
21	protein complex biogenesis (GO:0070271)	3.50080411
22	preassembly of GPI anchor in ER membrane (GO:0016254)	3.44174984
23	galactose catabolic process (GO:0019388)	3.42206336
24	ubiquinone biosynthetic process (GO:0006744)	3.37305040
25	arginine catabolic process (GO:0006527)	3.27088904
26	relaxation of smooth muscle (GO:0044557)	3.26973375
27	guanosine-containing compound biosynthetic process (GO:1901070)	3.26009993
28	pseudouridine synthesis (GO:0001522)	3.25076640
29	branched-chain amino acid metabolic process (GO:0009081)	3.24208788
30	regulation of cilium movement (GO:0003352)	3.22423334
31	peptidyl-arginine N-methylation (GO:0035246)	3.19282085
32	peptidyl-arginine methylation (GO:0018216)	3.19282085
33	mannosylation (GO:0097502)	3.17650750
34	mitochondrial respiratory chain complex assembly (GO:0033108)	3.16984304
35	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.16216721
36	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.16216721
37	nucleoside diphosphate phosphorylation (GO:0006165)	3.15420433
38	lipopolysaccharide biosynthetic process (GO:0009103)	3.12895723
39	carnitine metabolic process (GO:0009437)	3.12837148
40	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.12688813
41	photoreceptor cell maintenance (GO:0045494)	3.11519095
42	cilium morphogenesis (GO:0060271)	3.07400890
43	valine metabolic process (GO:0006573)	3.05177865
44	photoreceptor cell development (GO:0042461)	3.04850486
45	ADP metabolic process (GO:0046031)	3.04811718
46	intraciliary transport (GO:0042073)	3.04377154
47	CTP metabolic process (GO:0046036)	3.03750119
48	CTP biosynthetic process (GO:0006241)	3.03750119
49	platelet dense granule organization (GO:0060155)	3.03025336
50	eye photoreceptor cell development (GO:0042462)	3.01066171
51	positive regulation of TOR signaling (GO:0032008)	3.00375333
52	aspartate family amino acid catabolic process (GO:0009068)	2.98744016
53	zinc ion transmembrane transport (GO:0071577)	2.94333184
54	dicarboxylic acid catabolic process (GO:0043649)	2.92869225
55	cellular response to nicotine (GO:0071316)	2.92288620
56	ubiquinone metabolic process (GO:0006743)	2.92103285
57	positive regulation of amino acid transport (GO:0051957)	2.90745662
58	C-terminal protein lipidation (GO:0006501)	2.90271442
59	positive regulation of mitochondrial fission (GO:0090141)	2.87948519
60	fibroblast migration (GO:0010761)	2.87696323
61	tRNA methylation (GO:0030488)	2.87603698
62	amino-acid betaine metabolic process (GO:0006577)	2.86703249
63	inner ear receptor stereocilium organization (GO:0060122)	2.84241195
64	base-excision repair, AP site formation (GO:0006285)	2.83613870
65	xenobiotic catabolic process (GO:0042178)	2.80730193
66	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.80411453
67	motile cilium assembly (GO:0044458)	2.79116884
68	rRNA modification (GO:0000154)	2.78557837
69	adenosine metabolic process (GO:0046085)	2.76696567
70	short-chain fatty acid metabolic process (GO:0046459)	2.76235512
71	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.72560094
72	quinone biosynthetic process (GO:1901663)	2.71796712
73	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.70511110
74	myelin assembly (GO:0032288)	2.70084627
75	DNA strand renaturation (GO:0000733)	2.69305829
76	sperm motility (GO:0030317)	2.67651660
77	tRNA modification (GO:0006400)	2.66867170
78	negative regulation of defense response to virus (GO:0050687)	2.65088953
79	negative regulation of B cell apoptotic process (GO:0002903)	2.62602070
80	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.59504412
81	regulation of vacuole organization (GO:0044088)	2.58293100
82	GPI anchor metabolic process (GO:0006505)	2.57221283
83	L-methionine biosynthetic process (GO:0071265)	2.56333955
84	amino acid salvage (GO:0043102)	2.56333955
85	L-methionine salvage (GO:0071267)	2.56333955
86	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.54497452
87	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.54497452
88	regulation of autophagic vacuole assembly (GO:2000785)	2.54189523
89	epithelial cilium movement (GO:0003351)	2.53984268
90	nucleotide phosphorylation (GO:0046939)	2.53668103
91	serine family amino acid catabolic process (GO:0009071)	2.53461340
92	GPI anchor biosynthetic process (GO:0006506)	2.53340863
93	cell wall macromolecule catabolic process (GO:0016998)	2.51521846
94	cullin deneddylation (GO:0010388)	2.50467695
95	single fertilization (GO:0007338)	2.49913049
96	protein deneddylation (GO:0000338)	2.48965834
97	sperm-egg recognition (GO:0035036)	2.45696367
98	purine nucleotide salvage (GO:0032261)	2.44932904
99	mitochondrial RNA metabolic process (GO:0000959)	2.44836057
100	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.44722977

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.28987715
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.76306984
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.75892151
4	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	3.50012442
5	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.40731692
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.38836376
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.92013200
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.84919745
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.82258128
10	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.61378717
11	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.53819409
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.51208980
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.41551833
14	GABP_19822575_ChIP-Seq_HepG2_Human	2.41199110
15	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.34531751
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.33800558
17	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.20350203
18	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.19857017
19	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.09965534
20	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.00438519
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.98725713
22	DCP1A_22483619_ChIP-Seq_HELA_Human	1.97494006
23	VDR_22108803_ChIP-Seq_LS180_Human	1.87911983
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.86853323
25	IGF1R_20145208_ChIP-Seq_DFB_Human	1.82730444
26	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.78820926
27	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.77941659
28	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.77360940
29	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.77354289
30	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.72259293
31	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.60637912
32	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.58107918
33	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.54983162
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.54166385
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.50269979
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.50122904
37	TFEB_21752829_ChIP-Seq_HELA_Human	1.47270816
38	FOXP3_21729870_ChIP-Seq_TREG_Human	1.47080997
39	RAC3_21632823_ChIP-Seq_H3396_Human	1.46802890
40	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.46392592
41	EZH2_22144423_ChIP-Seq_EOC_Human	1.42216324
42	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.39215094
43	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.38018753
44	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.36229235
45	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.32768066
46	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.32507281
47	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.32344587
48	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.32105139
49	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.29930507
50	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.28911733
51	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.28011663
52	XRN2_22483619_ChIP-Seq_HELA_Human	1.27346454
53	PHF8_20622854_ChIP-Seq_HELA_Human	1.25615296
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.24966020
55	NANOG_20526341_ChIP-Seq_ESCs_Human	1.22533488
56	ERA_21632823_ChIP-Seq_H3396_Human	1.18253514
57	CTCF_20526341_ChIP-Seq_ESCs_Human	1.17914822
58	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.16537932
59	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.13923524
60	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.13737695
61	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.13534490
62	TP53_22127205_ChIP-Seq_IMR90_Human	1.12043060
63	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.11672181
64	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.11386109
65	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.10532823
66	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.08848621
67	BCL6_27268052_Chip-Seq_Bcells_Human	1.07077191
68	SPI1_20517297_ChIP-Seq_HL60_Human	1.06828617
69	CIITA_25753668_ChIP-Seq_RAJI_Human	1.05948680
70	E2F1_20622854_ChIP-Seq_HELA_Human	1.05817004
71	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.04642209
72	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.01657407
73	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.00378588
74	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.00372739
75	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.99814418
76	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.99624546
77	IRF1_19129219_ChIP-ChIP_H3396_Human	0.99589582
78	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.99309315
79	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.99202245
80	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.99023074
81	OCT4_20526341_ChIP-Seq_ESCs_Human	0.98958202
82	SOX2_21211035_ChIP-Seq_LN229_Human	0.98877890
83	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.98618270
84	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.98266838
85	STAT1_20625510_ChIP-Seq_HELA_Human	0.97860310
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97712259
87	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.96897076
88	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.95025782
89	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.94621547
90	P53_21459846_ChIP-Seq_SAOS-2_Human	0.93536780
91	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.92502483
92	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.92099996
93	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.92099996
94	KDM5A_27292631_Chip-Seq_BREAST_Human	0.91731261
95	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.91510421
96	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.89751243
97	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.88843035
98	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.86473250
99	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.85152637
100	TAF2_19829295_ChIP-Seq_ESCs_Human	0.85122794

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.46481209
2	MP0001529_abnormal_vocalization	3.01477108
3	MP0009697_abnormal_copulation	2.99939429
4	MP0001984_abnormal_olfaction	2.83290728
5	MP0003806_abnormal_nucleotide_metabolis	2.78103469
6	MP0005174_abnormal_tail_pigmentation	2.29578752
7	MP0004233_abnormal_muscle_weight	2.18178786
8	MP0003880_abnormal_central_pattern	2.14685744
9	MP0010386_abnormal_urinary_bladder	2.14482054
10	MP0006072_abnormal_retinal_apoptosis	2.06014654
11	MP0002234_abnormal_pharynx_morphology	2.04653411
12	MP0002638_abnormal_pupillary_reflex	2.02481001
13	MP0001764_abnormal_homeostasis	2.00987964
14	MP0005551_abnormal_eye_electrophysiolog	2.00377644
15	MP0001661_extended_life_span	1.94608512
16	MP0000372_irregular_coat_pigmentation	1.89315850
17	MP0005253_abnormal_eye_physiology	1.89174722
18	MP0008875_abnormal_xenobiotic_pharmacok	1.79431093
19	MP0005058_abnormal_lysosome_morphology	1.76016698
20	MP0002736_abnormal_nociception_after	1.74198881
21	MP0009278_abnormal_bone_marrow	1.72700176
22	MP0006036_abnormal_mitochondrial_physio	1.70113592
23	MP0008260_abnormal_autophagy	1.67754911
24	MP0004147_increased_porphyrin_level	1.64051585
25	MP0001545_abnormal_hematopoietic_system	1.63821860
26	MP0005397_hematopoietic_system_phenotyp	1.63821860
27	MP0000538_abnormal_urinary_bladder	1.62483019
28	MP0001905_abnormal_dopamine_level	1.61360867
29	MP0004272_abnormal_basement_membrane	1.61024896
30	MP0002269_muscular_atrophy	1.57200671
31	MP0005499_abnormal_olfactory_system	1.56773226
32	MP0005394_taste/olfaction_phenotype	1.56773226
33	MP0009250_abnormal_appendicular_skeleto	1.56073624
34	MP0005075_abnormal_melanosome_morpholog	1.51480553
35	MP0000465_gastrointestinal_hemorrhage	1.50868918
36	MP0009840_abnormal_foam_cell	1.49615497
37	MP0003136_yellow_coat_color	1.49575423
38	MP0004742_abnormal_vestibular_system	1.48263968
39	MP0003172_abnormal_lysosome_physiology	1.45576578
40	MP0002938_white_spotting	1.44977847
41	MP0003315_abnormal_perineum_morphology	1.41045127
42	MP0002132_abnormal_respiratory_system	1.38624575
43	MP0005503_abnormal_tendon_morphology	1.37512371
44	MP0003191_abnormal_cellular_cholesterol	1.34664878
45	MP0008995_early_reproductive_senescence	1.30380692
46	MP0001324_abnormal_eye_pigmentation	1.30042148
47	MP0005410_abnormal_fertilization	1.29003516
48	MP0002090_abnormal_vision	1.27525318
49	MP0002295_abnormal_pulmonary_circulatio	1.26828522
50	MP0001986_abnormal_taste_sensitivity	1.26803780
51	MP0005332_abnormal_amino_acid	1.26507110
52	MP0000516_abnormal_urinary_system	1.25965642
53	MP0005367_renal/urinary_system_phenotyp	1.25965642
54	MP0009046_muscle_twitch	1.25961801
55	MP0001502_abnormal_circadian_rhythm	1.25727994
56	MP0003186_abnormal_redox_activity	1.24504015
57	MP0000749_muscle_degeneration	1.22548083
58	MP0005595_abnormal_vascular_smooth	1.21775186
59	MP0001542_abnormal_bone_strength	1.18978654
60	MP0005330_cardiomyopathy	1.18914643
61	MP0002229_neurodegeneration	1.15268333
62	MP0005220_abnormal_exocrine_pancreas	1.12833880
63	MP0000358_abnormal_cell_content/	1.12563591
64	MP0001963_abnormal_hearing_physiology	1.11066363
65	MP0003656_abnormal_erythrocyte_physiolo	1.10707297
66	MP0002067_abnormal_sensory_capabilities	1.09953226
67	MP0006276_abnormal_autonomic_nervous	1.09346325
68	MP0002160_abnormal_reproductive_system	1.04354466
69	MP0001486_abnormal_startle_reflex	1.04158566
70	MP0001664_abnormal_digestion	0.99018326
71	MP0002557_abnormal_social/conspecific_i	0.97527364
72	MP0005645_abnormal_hypothalamus_physiol	0.95756112
73	MP0000026_abnormal_inner_ear	0.94045809
74	MP0002572_abnormal_emotion/affect_behav	0.93868625
75	MP0002752_abnormal_somatic_nervous	0.92985983
76	MP0002272_abnormal_nervous_system	0.92906063
77	MP0006054_spinal_hemorrhage	0.90101693
78	MP0000747_muscle_weakness	0.87136044
79	MP0008438_abnormal_cutaneous_collagen	0.86847556
80	MP0005084_abnormal_gallbladder_morpholo	0.85974871
81	MP0008789_abnormal_olfactory_epithelium	0.85893483
82	MP0006035_abnormal_mitochondrial_morpho	0.85479294
83	MP0004924_abnormal_behavior	0.84505757
84	MP0005386_behavior/neurological_phenoty	0.84505757
85	MP0000751_myopathy	0.84292526
86	MP0003698_abnormal_male_reproductive	0.84229826
87	MP0005171_absent_coat_pigmentation	0.82867764
88	MP0005646_abnormal_pituitary_gland	0.82852421
89	MP0005376_homeostasis/metabolism_phenot	0.81918920
90	MP0005508_abnormal_skeleton_morphology	0.78459369
91	MP0001968_abnormal_touch/_nociception	0.77619099
92	MP0004859_abnormal_synaptic_plasticity	0.76664874
93	MP0000049_abnormal_middle_ear	0.75689009
94	MP0002102_abnormal_ear_morphology	0.74743964
95	MP0005391_vision/eye_phenotype	0.74430361
96	MP0003942_abnormal_urinary_system	0.72365284
97	MP0003385_abnormal_body_wall	0.70987116
98	MP0008058_abnormal_DNA_repair	0.70858958
99	MP0001270_distended_abdomen	0.70549739
100	MP0001756_abnormal_urination	0.70171599

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Microvesicular hepatic steatosis (HP:0001414)	5.73688764
2	Abnormal protein glycosylation (HP:0012346)	3.92840386
3	Abnormal glycosylation (HP:0012345)	3.92840386
4	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.92840386
5	Abnormal protein N-linked glycosylation (HP:0012347)	3.92840386
6	Type I transferrin isoform profile (HP:0003642)	3.47660031
7	Tongue fasciculations (HP:0001308)	3.42736462
8	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.40538911
9	Gait imbalance (HP:0002141)	3.26738767
10	Congenital primary aphakia (HP:0007707)	3.02418119
11	Abnormality of dicarboxylic acid metabolism (HP:0010995)	3.01597297
12	Dicarboxylic aciduria (HP:0003215)	3.01597297
13	Reduced antithrombin III activity (HP:0001976)	2.98526638
14	Medial flaring of the eyebrow (HP:0010747)	2.96222014
15	Hypokinesia (HP:0002375)	2.92230782
16	Nephrogenic diabetes insipidus (HP:0009806)	2.91358735
17	Hyperglycinemia (HP:0002154)	2.90394067
18	Retinal dysplasia (HP:0007973)	2.88223987
19	Cerebral edema (HP:0002181)	2.87630684
20	Redundant skin (HP:0001582)	2.80234276
21	Type II lissencephaly (HP:0007260)	2.74283719
22	Hyperglycinuria (HP:0003108)	2.74224660
23	Acute encephalopathy (HP:0006846)	2.73486018
24	Cerebellar dysplasia (HP:0007033)	2.71732469
25	Follicular hyperkeratosis (HP:0007502)	2.71381675
26	Abnormality of serine family amino acid metabolism (HP:0010894)	2.71319769
27	Abnormality of glycine metabolism (HP:0010895)	2.71319769
28	Abnormal mitochondria in muscle tissue (HP:0008316)	2.68343250
29	Muscle fibrillation (HP:0010546)	2.67461507
30	Abnormality of B cell number (HP:0010975)	2.65449240
31	True hermaphroditism (HP:0010459)	2.63095862
32	Short tibia (HP:0005736)	2.56921391
33	Thoracic kyphosis (HP:0002942)	2.56561346
34	Nephronophthisis (HP:0000090)	2.48946953
35	Amyotrophic lateral sclerosis (HP:0007354)	2.48834830
36	Acute necrotizing encephalopathy (HP:0006965)	2.46786586
37	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.45732277
38	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.45732277
39	Poor head control (HP:0002421)	2.44350110
40	Ketosis (HP:0001946)	2.43657575
41	Pancreatic fibrosis (HP:0100732)	2.42938845
42	Recurrent corneal erosions (HP:0000495)	2.38917667
43	Entropion (HP:0000621)	2.36046399
44	Abnormality of dental color (HP:0011073)	2.31214715
45	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.31176185
46	Absent/shortened dynein arms (HP:0200106)	2.31176185
47	Seborrheic dermatitis (HP:0001051)	2.29885351
48	Abnormal rod and cone electroretinograms (HP:0008323)	2.29177200
49	Abnormal number of erythroid precursors (HP:0012131)	2.28777746
50	Poikiloderma (HP:0001029)	2.27677899
51	Abnormal gallbladder physiology (HP:0012438)	2.26616570
52	Cholecystitis (HP:0001082)	2.26616570
53	Lactic acidosis (HP:0003128)	2.25247159
54	Attenuation of retinal blood vessels (HP:0007843)	2.24741249
55	Exercise intolerance (HP:0003546)	2.24366270
56	Decreased central vision (HP:0007663)	2.24280266
57	Hypertensive crisis (HP:0100735)	2.23287561
58	3-Methylglutaconic aciduria (HP:0003535)	2.22557072
59	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.20394359
60	Abnormality of liposaccharide metabolism (HP:0010968)	2.17291698
61	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.17291698
62	Abnormality of glycolipid metabolism (HP:0010969)	2.17291698
63	B lymphocytopenia (HP:0010976)	2.16971823
64	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.14863274
65	Poor coordination (HP:0002370)	2.08905152
66	Polyphagia (HP:0002591)	2.08835002
67	Unsteady gait (HP:0002317)	2.08694058
68	Pancreatic cysts (HP:0001737)	2.07329121
69	Broad foot (HP:0001769)	2.06340567
70	Thrombocytosis (HP:0001894)	2.04551187
71	Abnormality of glycolysis (HP:0004366)	2.02715231
72	Abolished electroretinogram (ERG) (HP:0000550)	2.02061066
73	Abnormal ciliary motility (HP:0012262)	2.01723718
74	Mitochondrial inheritance (HP:0001427)	1.97762826
75	Ragged-red muscle fibers (HP:0003200)	1.97491128
76	Spastic paraparesis (HP:0002313)	1.96799388
77	Genital tract atresia (HP:0001827)	1.96544600
78	Methylmalonic aciduria (HP:0012120)	1.95758461
79	Hepatic necrosis (HP:0002605)	1.95715657
80	Overfolded helix (HP:0000396)	1.95450001
81	Abnormality of midbrain morphology (HP:0002418)	1.95082743
82	Molar tooth sign on MRI (HP:0002419)	1.95082743
83	Abnormal respiratory epithelium morphology (HP:0012253)	1.94050080
84	Abnormal respiratory motile cilium morphology (HP:0005938)	1.94050080
85	Increased CSF lactate (HP:0002490)	1.93348343
86	Increased serum pyruvate (HP:0003542)	1.92372853
87	Ketoacidosis (HP:0001993)	1.92162335
88	Increased serum lactate (HP:0002151)	1.92088071
89	Granulocytopenia (HP:0001913)	1.91653885
90	Progressive macrocephaly (HP:0004481)	1.90803112
91	Disproportionate short-trunk short stature (HP:0003521)	1.89407815
92	Hepatocellular necrosis (HP:0001404)	1.84458788
93	Aplasia/Hypoplasia of the lens (HP:0008063)	1.84419471
94	Retinitis pigmentosa (HP:0000510)	1.83397965
95	Vaginal atresia (HP:0000148)	1.83016580
96	Neonatal respiratory distress (HP:0002643)	1.82233802
97	Ulnar claw (HP:0001178)	1.78465261
98	Rhabdomyolysis (HP:0003201)	1.75363916
99	Delayed gross motor development (HP:0002194)	1.73920233
100	Hyperammonemia (HP:0001987)	1.73599479

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	5.09964812
2	NME2	3.17143990
3	PIM2	3.07896108
4	LIMK1	3.06123971
5	ADRBK2	2.88221953
6	MYLK	2.84911564
7	PBK	2.80524486
8	PINK1	2.71840040
9	GRK1	2.27662085
10	CSNK1G3	2.12762530
11	ARAF	2.03444935
12	CSNK1A1L	1.91538162
13	PTK2B	1.85097253
14	MAP2K7	1.79858429
15	CSNK1G2	1.77639367
16	MAPKAPK5	1.77523684
17	TESK2	1.77077814
18	ICK	1.74131846
19	BMPR2	1.73678851
20	MARK1	1.72567141
21	MARK3	1.71612821
22	EIF2AK3	1.65412465
23	KIT	1.55281153
24	STK16	1.53411991
25	EPHA4	1.48061282
26	TESK1	1.47275381
27	VRK2	1.46520253
28	FLT3	1.32708951
29	CSNK1G1	1.28375347
30	RPS6KA5	1.23847844
31	MOS	1.16335480
32	MAP3K5	1.16048780
33	ILK	1.09940720
34	RPS6KA4	1.06690880
35	MAPK13	1.05376244
36	KDR	1.01817968
37	DYRK3	0.99467397
38	STK38	0.96527586
39	DYRK2	0.95568842
40	GRK6	0.94606354
41	TAOK3	0.91143362
42	CAMK2D	0.87834281
43	BLK	0.87696482
44	CDK14	0.86163171
45	CAMK2B	0.84827195
46	CAMKK2	0.83963440
47	CDK19	0.83915278
48	FRK	0.82922393
49	NUAK1	0.82308275
50	ABL2	0.81018737
51	TBK1	0.80697156
52	DAPK1	0.80528274
53	DAPK3	0.80360014
54	GRK7	0.77043591
55	CDK9	0.74578603
56	MAPKAPK3	0.74507527
57	JAK3	0.74179631
58	PKN1	0.71924350
59	CASK	0.71409591
60	NEK9	0.69607195
61	BMPR1B	0.69223748
62	CAMK2G	0.66225076
63	CDK8	0.65826238
64	PLK2	0.65200953
65	NEK2	0.64853251
66	CCNB1	0.62929595
67	ADRBK1	0.62526701
68	PRKD2	0.62495222
69	IKBKB	0.60988732
70	PAK1	0.58637515
71	DYRK1B	0.56670948
72	MAP4K2	0.55987048
73	ATR	0.55040097
74	CDK3	0.54079832
75	MAP3K12	0.52209512
76	PHKG2	0.52196421
77	PHKG1	0.52196421
78	SIK2	0.51489814
79	MAPKAPK2	0.50589439
80	MUSK	0.49528644
81	AKT2	0.49423606
82	CAMK2A	0.48905956
83	OBSCN	0.46713443
84	MAPK11	0.46373479
85	PRKCE	0.45270573
86	WNK3	0.45188888
87	FER	0.43971342
88	NTRK2	0.41936118
89	SIK3	0.41664675
90	TIE1	0.41115374
91	CDK18	0.39007037
92	CDK15	0.38686062
93	CDK5	0.36934026
94	BRSK2	0.36455002
95	SYK	0.35897083
96	PRKD1	0.35422202
97	MATK	0.35068426
98	GRK5	0.34352413
99	SRPK1	0.34330188
100	TNK2	0.33428548

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.06208280
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.03547372
3	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.88838490
4	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.81728696
5	Butanoate metabolism_Homo sapiens_hsa00650	2.58547858
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.52179244
7	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.20034212
8	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.12201152
9	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.09393400
10	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.07810775
11	Propanoate metabolism_Homo sapiens_hsa00640	1.96249204
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.93335073
13	Glutathione metabolism_Homo sapiens_hsa00480	1.87034578
14	Base excision repair_Homo sapiens_hsa03410	1.86813401
15	Pyrimidine metabolism_Homo sapiens_hsa00240	1.77651163
16	Sulfur relay system_Homo sapiens_hsa04122	1.75432564
17	Fatty acid elongation_Homo sapiens_hsa00062	1.72589899
18	Steroid biosynthesis_Homo sapiens_hsa00100	1.72416146
19	Peroxisome_Homo sapiens_hsa04146	1.72080714
20	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.67484444
21	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.64319732
22	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.58634300
23	Other glycan degradation_Homo sapiens_hsa00511	1.58363036
24	Fatty acid degradation_Homo sapiens_hsa00071	1.56219051
25	Parkinsons disease_Homo sapiens_hsa05012	1.53653358
26	Protein export_Homo sapiens_hsa03060	1.52646565
27	Olfactory transduction_Homo sapiens_hsa04740	1.51875243
28	RNA polymerase_Homo sapiens_hsa03020	1.43109034
29	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.41956882
30	Basal transcription factors_Homo sapiens_hsa03022	1.37833367
31	Carbon metabolism_Homo sapiens_hsa01200	1.33496821
32	Purine metabolism_Homo sapiens_hsa00230	1.29835152
33	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.29696940
34	Tyrosine metabolism_Homo sapiens_hsa00350	1.28776152
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.26353054
36	Oxidative phosphorylation_Homo sapiens_hsa00190	1.25214731
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.24519005
38	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.16038703
39	Pentose phosphate pathway_Homo sapiens_hsa00030	1.15626263
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.11746139
41	Nucleotide excision repair_Homo sapiens_hsa03420	1.09168324
42	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.07274854
43	One carbon pool by folate_Homo sapiens_hsa00670	1.07262416
44	beta-Alanine metabolism_Homo sapiens_hsa00410	1.07106075
45	Regulation of autophagy_Homo sapiens_hsa04140	1.05171169
46	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.04143839
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.04003071
48	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.02258921
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.99240767
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.97793463
51	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.97115492
52	Metabolic pathways_Homo sapiens_hsa01100	0.96395596
53	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.94771697
54	Arginine and proline metabolism_Homo sapiens_hsa00330	0.93282609
55	Phenylalanine metabolism_Homo sapiens_hsa00360	0.91787739
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.91687980
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.91376155
58	Galactose metabolism_Homo sapiens_hsa00052	0.89796916
59	Proteasome_Homo sapiens_hsa03050	0.89677174
60	Phototransduction_Homo sapiens_hsa04744	0.89233296
61	Fanconi anemia pathway_Homo sapiens_hsa03460	0.85973129
62	Asthma_Homo sapiens_hsa05310	0.85103071
63	RNA degradation_Homo sapiens_hsa03018	0.84600347
64	Huntingtons disease_Homo sapiens_hsa05016	0.79502722
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.78964349
66	Pyruvate metabolism_Homo sapiens_hsa00620	0.76517339
67	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.76140884
68	Lysine degradation_Homo sapiens_hsa00310	0.75378942
69	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.74667240
70	Selenocompound metabolism_Homo sapiens_hsa00450	0.73593105
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.70880756
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66742057
73	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.66651420
74	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.66528205
75	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.64709226
76	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.62577911
77	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.61885194
78	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.60590912
79	Melanoma_Homo sapiens_hsa05218	0.58160206
80	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.57528213
81	Linoleic acid metabolism_Homo sapiens_hsa00591	0.55519772
82	Alzheimers disease_Homo sapiens_hsa05010	0.54740217
83	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53740525
84	Phagosome_Homo sapiens_hsa04145	0.53649586
85	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.53486282
86	Circadian rhythm_Homo sapiens_hsa04710	0.51798659
87	Lysosome_Homo sapiens_hsa04142	0.51498689
88	DNA replication_Homo sapiens_hsa03030	0.50736787
89	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.47766656
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45202151
91	Cocaine addiction_Homo sapiens_hsa05030	0.44425912
92	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.41156302
93	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.38802938
94	Folate biosynthesis_Homo sapiens_hsa00790	0.35829563
95	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.33953320
96	Alcoholism_Homo sapiens_hsa05034	0.31522099
97	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.28863839
98	Primary immunodeficiency_Homo sapiens_hsa05340	0.28544865
99	Sulfur metabolism_Homo sapiens_hsa00920	0.26329351
100	Retinol metabolism_Homo sapiens_hsa00830	0.24741459

FAM86FP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »