FAM86GP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of 5.8S rRNA (GO:0000460)9.73103610
2regulation of mitochondrial translation (GO:0070129)9.11356884
3positive regulation of signal transduction by p53 class mediator (GO:1901798)9.06381633
4regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)8.49535469
5secretory granule organization (GO:0033363)8.17707851
6platelet formation (GO:0030220)7.18151507
7cytochrome complex assembly (GO:0017004)6.80677579
8negative regulation of translational initiation (GO:0045947)6.67219702
9negative regulation of signal transduction by p53 class mediator (GO:1901797)6.38063888
10negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)5.69455152
11pseudouridine synthesis (GO:0001522)5.52437213
12establishment of protein localization to mitochondrial membrane (GO:0090151)5.50426435
13regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)5.45919678
14regulation of translation in response to stress (GO:0043555)5.25733248
15fusion of sperm to egg plasma membrane (GO:0007342)4.98958933
16regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902229)4.77286478
17positive regulation of macrophage differentiation (GO:0045651)4.55820367
18negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.42864339
19myeloid cell development (GO:0061515)4.35354951
20glucose 6-phosphate metabolic process (GO:0051156)4.27434988
21regulation of translational initiation (GO:0006446)4.26890163
22DNA replication-dependent nucleosome organization (GO:0034723)4.26189127
23DNA replication-dependent nucleosome assembly (GO:0006335)4.26189127
24pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.04498840
25regulation of B cell differentiation (GO:0045577)4.00516189
26protein complex biogenesis (GO:0070271)3.89371979
27regulation of signal transduction by p53 class mediator (GO:1901796)3.89149117
28negative regulation of membrane potential (GO:0045837)3.88200362
29piRNA metabolic process (GO:0034587)3.84168718
30regulation of nucleobase-containing compound transport (GO:0032239)3.82406331
31plasma membrane fusion (GO:0045026)3.79566796
32ribosomal small subunit biogenesis (GO:0042274)3.76757667
33regulation of necrotic cell death (GO:0010939)3.75938993
34T cell apoptotic process (GO:0070231)3.73640088
35ribosomal small subunit assembly (GO:0000028)3.71249128
36mitochondrial respiratory chain complex assembly (GO:0033108)3.71146795
37cellular protein catabolic process (GO:0044257)3.69959648
38production of molecular mediator involved in inflammatory response (GO:0002532)3.68411145
39erythrocyte maturation (GO:0043249)3.67084483
40positive regulation of translation (GO:0045727)3.65423069
41regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.62265030
42negative regulation of chemokine production (GO:0032682)3.53868069
43positive regulation of fat cell differentiation (GO:0045600)3.53238890
44inner mitochondrial membrane organization (GO:0007007)3.48890849
45positive regulation of response to DNA damage stimulus (GO:2001022)3.48010547
46negative regulation of response to DNA damage stimulus (GO:2001021)3.46743902
47regulation of necroptotic process (GO:0060544)3.46496284
48determination of adult lifespan (GO:0008340)3.44486824
49protein kinase B signaling (GO:0043491)3.40136840
50pyrimidine nucleotide catabolic process (GO:0006244)3.39982504
51respiratory chain complex IV assembly (GO:0008535)3.37730099
52necroptotic process (GO:0070266)3.37010082
53positive regulation of mast cell activation involved in immune response (GO:0033008)3.32190097
54positive regulation of mast cell degranulation (GO:0043306)3.32190097
55fibril organization (GO:0097435)3.27148801
56rRNA modification (GO:0000154)3.25311896
57response to food (GO:0032094)3.09917321
58lymphocyte apoptotic process (GO:0070227)3.08235931
59NADPH regeneration (GO:0006740)3.04497323
60histone H4-K12 acetylation (GO:0043983)3.03480578
61regulation of double-strand break repair via homologous recombination (GO:0010569)2.96101227
62DNA packaging (GO:0006323)2.95863625
63ubiquinone biosynthetic process (GO:0006744)2.90564628
64lamellipodium assembly (GO:0030032)2.82119727
65L-serine metabolic process (GO:0006563)2.82116341
66regulation of translation (GO:0006417)2.79497845
67regulation of telomere maintenance via telomerase (GO:0032210)2.77441562
68neural tube formation (GO:0001841)2.75667001
69regulation of chemokine biosynthetic process (GO:0045073)2.74921973
70viral transcription (GO:0019083)2.70664685
71oligodendrocyte development (GO:0014003)2.66984879
72translational termination (GO:0006415)2.66623828
73formation of translation preinitiation complex (GO:0001731)2.66550846
74heterochromatin organization (GO:0070828)2.66165218
75translational initiation (GO:0006413)2.64219507
76ubiquinone metabolic process (GO:0006743)2.64096658
77sequestering of extracellular ligand from receptor (GO:0035581)2.63059940
78pentose-phosphate shunt (GO:0006098)2.61850917
79purine ribonucleotide transport (GO:0015868)2.60930442
80positive regulation of mitochondrial membrane permeability (GO:0035794)2.60814057
81regulation of memory T cell differentiation (GO:0043380)2.57194177
82positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.56213730
83regulation of oxidative phosphorylation (GO:0002082)2.52584310
84lipoxygenase pathway (GO:0019372)2.52219173
85cellular response to interferon-beta (GO:0035458)2.50641036
86chromatin assembly (GO:0031497)2.47991917
87adenine nucleotide transport (GO:0051503)2.46861048
88regulation of macrophage differentiation (GO:0045649)2.44830826
89positive regulation of mast cell activation (GO:0033005)2.43790069
90DNA integration (GO:0015074)2.42906181
91lamellipodium organization (GO:0097581)2.41567088
92positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.39229324
93RNA localization (GO:0006403)15.6278314
94signal complex assembly (GO:0007172)12.5355841
95negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 12.2123782
96positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)11.3550521
97regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 10.3466224
98positive regulation of translational initiation (GO:0045948)10.3353530
99negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)10.3025720
100megakaryocyte development (GO:0035855)10.2642547

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human7.81794975
2E2F7_22180533_ChIP-Seq_HELA_Human3.95099481
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.66180493
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.50148836
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.25977550
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.88024919
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.87512357
8TP53_16413492_ChIP-PET_HCT116_Human2.81926977
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.67150711
10EGR1_19032775_ChIP-ChIP_M12_Human2.60298527
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.55250760
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.45345401
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41530685
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.28824980
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.26484497
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.22758071
17VDR_22108803_ChIP-Seq_LS180_Human2.21292345
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.13819687
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.07632419
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.06618088
21TBX3_20139965_ChIP-Seq_ESCs_Mouse2.02155996
22TBX3_20139965_ChIP-Seq_MESCs_Mouse2.00216112
23AR_21572438_ChIP-Seq_LNCaP_Human1.97486624
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.93710214
25ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.91674597
26NANOG_16153702_ChIP-ChIP_HESCs_Human1.91361333
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.81832594
28SOX2_16153702_ChIP-ChIP_HESCs_Human1.80408639
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77785413
30MYC_18940864_ChIP-ChIP_HL60_Human1.77229522
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77029989
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72710803
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.72521163
34SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.71906149
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71281423
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.69850405
37RNF2_27304074_Chip-Seq_NSC_Mouse1.65127299
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64882450
39SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.62523415
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.62340669
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59390286
42AR_21909140_ChIP-Seq_LNCAP_Human1.58106106
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55537115
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55059384
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52425991
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50543113
47NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.49775041
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.46844918
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46708145
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46580751
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44499990
52STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.37008745
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36222627
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31632630
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28684935
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28463882
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.27599702
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.27599702
59KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.27599702
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26461770
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19883777
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.18575127
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18220727
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18180464
65GABP_17652178_ChIP-ChIP_JURKAT_Human1.17850165
66ELK1_19687146_ChIP-ChIP_HELA_Human1.17648037
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16519644
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13008941
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10272814
70EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.09728014
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09265316
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08094517
73FOXP3_21729870_ChIP-Seq_TREG_Human1.06874616
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.05202604
75CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04902605
76ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00644123
77FOXM1_23109430_ChIP-Seq_U2OS_Human1.00519641
78CIITA_25753668_ChIP-Seq_RAJI_Human0.98117807
79TTF2_22483619_ChIP-Seq_HELA_Human0.97814105
80ZNF274_21170338_ChIP-Seq_K562_Hela0.97706103
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97044299
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96988149
83WDR5_24793694_ChIP-Seq_LNCAP_Human0.96020026
84SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.95030694
85P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94799785
86LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94492190
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91654883
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90975469
89TDRD3_21172665_ChIP-Seq_MCF-7_Human0.89385260
90NANOG_20526341_ChIP-Seq_ESCs_Human0.88039687
91NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87702682
92NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87355428
93EZH2_27294783_Chip-Seq_NPCs_Mouse0.84114107
94BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83910848
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82779864
96TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.80763497
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80037999
98XRN2_22483619_ChIP-Seq_HELA_Human0.79838092
99YY1_22570637_ChIP-Seq_MALME-3M_Human0.79792786
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78572831

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.77680252
2MP0006292_abnormal_olfactory_placode3.86007692
3MP0004147_increased_porphyrin_level3.64557310
4MP0006035_abnormal_mitochondrial_morpho3.42712044
5MP0004957_abnormal_blastocyst_morpholog3.39203417
6MP0001661_extended_life_span3.31974284
7MP0005503_abnormal_tendon_morphology3.30668965
8MP0002277_abnormal_respiratory_mucosa2.87663344
9MP0008877_abnormal_DNA_methylation2.85230971
10MP0005410_abnormal_fertilization2.76683785
11MP0004145_abnormal_muscle_electrophysio2.60576821
12MP0002938_white_spotting2.49108060
13MP0003941_abnormal_skin_development2.35971649
14MP0000579_abnormal_nail_morphology2.25696227
15MP0008058_abnormal_DNA_repair2.20848893
16MP0003693_abnormal_embryo_hatching2.15662293
17MP0010094_abnormal_chromosome_stability2.11751111
18MP0000462_abnormal_digestive_system2.05401020
19MP0003111_abnormal_nucleus_morphology1.99199881
20MP0000372_irregular_coat_pigmentation1.91121766
21MP0002254_reproductive_system_inflammat1.90805050
22MP0008932_abnormal_embryonic_tissue1.83258603
23MP0005084_abnormal_gallbladder_morpholo1.78988232
24MP0003718_maternal_effect1.68493634
25MP0009672_abnormal_birth_weight1.64966500
26MP0003195_calcinosis1.62427013
27MP0005083_abnormal_biliary_tract1.60195240
28MP0003937_abnormal_limbs/digits/tail_de1.51789832
29MP0000358_abnormal_cell_content/1.43173865
30MP0010030_abnormal_orbit_morphology1.36864954
31MP0003436_decreased_susceptibility_to1.34725218
32MP0002108_abnormal_muscle_morphology1.34444588
33MP0006072_abnormal_retinal_apoptosis1.33555400
34MP0001727_abnormal_embryo_implantation1.33277580
35MP0004133_heterotaxia1.33026740
36MP0004215_abnormal_myocardial_fiber1.25701504
37MP0003119_abnormal_digestive_system1.23491838
38MP0009250_abnormal_appendicular_skeleto1.22180007
39MP0002736_abnormal_nociception_after1.20400504
40MP0000566_synostosis1.17159232
41MP0002102_abnormal_ear_morphology1.17075159
42MP0003077_abnormal_cell_cycle1.12890117
43MP0000534_abnormal_ureter_morphology1.08713507
44MP0003137_abnormal_impulse_conducting1.07202903
45MP0001243_abnormal_dermal_layer1.04683913
46MP0001293_anophthalmia1.00809171
47MP0009697_abnormal_copulation1.00419887
48MP0000639_abnormal_adrenal_gland0.97563521
49MP0008995_early_reproductive_senescence0.97046670
50MP0004130_abnormal_muscle_cell0.96638651
51MP0002697_abnormal_eye_size0.93425794
52MP0000631_abnormal_neuroendocrine_gland0.92495811
53MP0003567_abnormal_fetal_cardiomyocyte0.88713815
54MP0010307_abnormal_tumor_latency0.88218826
55MP0003136_yellow_coat_color0.87985887
56MP0002751_abnormal_autonomic_nervous0.86864016
57MP0009764_decreased_sensitivity_to0.86774799
58MP0001529_abnormal_vocalization0.86202037
59MP0006276_abnormal_autonomic_nervous0.85977058
60MP0008789_abnormal_olfactory_epithelium0.84648497
61MP0001286_abnormal_eye_development0.84222354
62MP0000751_myopathy0.83016667
63MP0001697_abnormal_embryo_size0.82370977
64MP0008004_abnormal_stomach_pH0.81657403
65MP0005187_abnormal_penis_morphology0.81455549
66MP0005332_abnormal_amino_acid0.78977354
67MP0002085_abnormal_embryonic_tissue0.77755153
68MP0002089_abnormal_postnatal_growth/wei0.77264034
69MP0003938_abnormal_ear_development0.74877140
70MP0003315_abnormal_perineum_morphology0.72862231
71MP0006036_abnormal_mitochondrial_physio0.72223383
72MP0006054_spinal_hemorrhage0.71822685
73MP0004185_abnormal_adipocyte_glucose0.71214949
74MP0000049_abnormal_middle_ear0.71047134
75MP0009046_muscle_twitch0.70458339
76MP0001730_embryonic_growth_arrest0.70303783
77MP0005647_abnormal_sex_gland0.70302452
78MP0003880_abnormal_central_pattern0.69568131
79MP0002160_abnormal_reproductive_system0.69128395
80MP0002169_no_abnormal_phenotype0.68669581
81MP0002873_normal_phenotype0.67739929
82MP0009703_decreased_birth_body0.67240412
83MP0002111_abnormal_tail_morphology0.66886084
84MP0008057_abnormal_DNA_replication0.66516715
85MP0008260_abnormal_autophagy0.66188898
86MP0001968_abnormal_touch/_nociception0.63208689
87MP0001346_abnormal_lacrimal_gland0.62882266
88MP0005499_abnormal_olfactory_system0.62471271
89MP0005394_taste/olfaction_phenotype0.62471271
90MP0002971_abnormal_brown_adipose0.61165071
91MP0002084_abnormal_developmental_patter0.60239615
92MP0001666_abnormal_nutrient_absorption0.59047418
93MP0002233_abnormal_nose_morphology0.58975599
94MP0003787_abnormal_imprinting0.57361638
95MP0003122_maternal_imprinting0.56867227
96MP0001119_abnormal_female_reproductive0.56452722
97MP0002796_impaired_skin_barrier0.56049004
98MP0003698_abnormal_male_reproductive0.56000358
99MP0002210_abnormal_sex_determination0.55585488
100MP0005646_abnormal_pituitary_gland0.55415822

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)8.12590372
2Premature ovarian failure (HP:0008209)5.32019541
3Secondary amenorrhea (HP:0000869)4.72567218
4Delusions (HP:0000746)4.59100209
5Carpal bone hypoplasia (HP:0001498)4.53348457
6Small epiphyses (HP:0010585)4.37540549
7Concave nail (HP:0001598)4.13362344
8Oral leukoplakia (HP:0002745)4.10361958
9IgM deficiency (HP:0002850)3.94751352
10Postnatal microcephaly (HP:0005484)3.90981984
11Aplastic anemia (HP:0001915)3.62074760
12Personality changes (HP:0000751)3.56075056
13CNS hypomyelination (HP:0003429)3.56047690
14Bifid tongue (HP:0010297)3.38501988
15Unsteady gait (HP:0002317)3.36098211
16Facial diplegia (HP:0001349)3.16078421
17Abnormal number of incisors (HP:0011064)3.14564775
18Multiple enchondromatosis (HP:0005701)3.11573871
19Abnormality of the labia minora (HP:0012880)3.10231585
20Rough bone trabeculation (HP:0100670)3.04259143
21Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.02412576
22Aplasia of the musculature (HP:0100854)2.93712783
23Abnormal lung lobation (HP:0002101)2.90430459
24Colon cancer (HP:0003003)2.83770549
25Septo-optic dysplasia (HP:0100842)2.81955646
26Irregular epiphyses (HP:0010582)2.73693126
27Agitation (HP:0000713)2.73594552
28Abnormality of cochlea (HP:0000375)2.61207355
29Macrocytic anemia (HP:0001972)2.58330648
30Asplenia (HP:0001746)2.55426665
31Reticulocytosis (HP:0001923)2.52616942
32Testicular atrophy (HP:0000029)2.48913334
33Pendular nystagmus (HP:0012043)2.48580335
34Cellular immunodeficiency (HP:0005374)2.48353262
35Aplasia/Hypoplasia involving the musculature (HP:0001460)2.46771988
36Adrenal hypoplasia (HP:0000835)2.45002144
37Alveolar cell carcinoma (HP:0006519)2.44187288
38Abnormality of chromosome stability (HP:0003220)2.39453784
39Abnormality of reticulocytes (HP:0004312)2.38912134
40Aplasia/Hypoplasia of the spleen (HP:0010451)2.36696750
41Abnormal trabecular bone morphology (HP:0100671)2.35654467
42Prolonged neonatal jaundice (HP:0006579)2.33055335
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.26565442
44Short hallux (HP:0010109)2.23354683
45Meckel diverticulum (HP:0002245)2.23192446
46Median cleft lip (HP:0000161)2.22727917
47Birth length less than 3rd percentile (HP:0003561)2.20588195
48Pterygium (HP:0001059)2.20554925
49Hyperglycinemia (HP:0002154)2.17789618
50Triphalangeal thumb (HP:0001199)2.16746686
51Horseshoe kidney (HP:0000085)2.16599294
52Central scotoma (HP:0000603)2.15322856
53Pancytopenia (HP:0001876)2.14467124
54Scotoma (HP:0000575)2.13862432
55Neoplasm of the tracheobronchial system (HP:0100552)2.13843055
56Reticulocytopenia (HP:0001896)2.09979760
57Ileus (HP:0002595)2.08455324
58Pallor (HP:0000980)2.07556372
59Patellar aplasia (HP:0006443)2.06750308
60Abnormality of the ileum (HP:0001549)2.06161973
61Epiphyseal dysplasia (HP:0002656)2.05801008
62Aplasia/Hypoplasia of the hallux (HP:0008362)2.03833820
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.03574858
64Delayed epiphyseal ossification (HP:0002663)1.99337162
65Abnormality of the phalanges of the 2nd finger (HP:0009541)1.98709667
66Chromsome breakage (HP:0040012)1.97933262
67Morphological abnormality of the inner ear (HP:0011390)1.95301749
68Absent phalangeal crease (HP:0006109)1.94790438
69Restlessness (HP:0000711)1.93370284
70CNS demyelination (HP:0007305)1.92608441
71Tracheoesophageal fistula (HP:0002575)1.91694268
72Absent septum pellucidum (HP:0001331)1.90610016
73Breast aplasia (HP:0100783)1.90082576
74Premature graying of hair (HP:0002216)1.89318271
75Increased hepatocellular lipid droplets (HP:0006565)1.88907424
76Hyperbilirubinemia (HP:0002904)1.88893406
77Hypoplastic pelvis (HP:0008839)1.88404428
78Poor speech (HP:0002465)1.86045810
79Aplasia/Hypoplasia of the patella (HP:0006498)1.84050340
80Stenosis of the external auditory canal (HP:0000402)1.83799763
81Abnormality of serum amino acid levels (HP:0003112)1.82918227
82Increased corneal curvature (HP:0100692)1.82604397
83Keratoconus (HP:0000563)1.82604397
84Mild short stature (HP:0003502)1.79176138
85Facial cleft (HP:0002006)1.78764343
86Sudden death (HP:0001699)1.78759891
87Impaired proprioception (HP:0010831)1.76853210
88Abnormal finger flexion creases (HP:0006143)1.75503543
89Abnormality of the preputium (HP:0100587)1.75196044
90Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.75047271
91Abnormality of glycine metabolism (HP:0010895)1.73915273
92Abnormality of serine family amino acid metabolism (HP:0010894)1.73915273
93Methylmalonic acidemia (HP:0002912)1.73627801
94Abnormality of the middle phalanges of the toes (HP:0010183)1.72561462
95Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.71772030
96Aplasia/Hypoplasia of the breasts (HP:0010311)1.70847468
97Selective tooth agenesis (HP:0001592)1.64057612
98Emotional lability (HP:0000712)1.63020071
99Abnormality of the duodenum (HP:0002246)1.62155507
100Short tibia (HP:0005736)1.59452040

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKCI3.82584652
2BMPR23.60901478
3EIF2AK32.96654179
4NEK12.41614865
5MAP4K12.25183602
6RIPK113.3984271
7PASK1.91639710
8ZAK1.80499784
9MAPKAPK31.74494654
10DAPK31.72192149
11PRKCG1.67424263
12PDPK11.54567806
13TTK1.35010175
14YES11.26162582
15TSSK61.25315510
16PRKCE1.24592452
17CDC71.24155304
18STK38L1.23857734
19STK241.15984629
20PLK41.10801577
21WNK31.05486969
22FGR1.03361465
23BUB11.00902673
24PLK30.99959979
25TNIK0.95767689
26MKNK20.86698339
27TRIM280.84721645
28FLT30.82686969
29DAPK10.78261764
30PRKCZ0.75407532
31MKNK10.74999988
32EPHA40.71571423
33PRKCD0.69448587
34VRK20.68832179
35NTRK10.62743969
36WEE10.62380827
37DYRK30.59979185
38PLK10.54516251
39CLK10.53731583
40PBK0.53657346
41SRPK10.50842649
42STK40.45032293
43GRK10.43062595
44ATR0.41844613
45VRK10.40752302
46EIF2AK20.38767469
47BMPR1B0.38678482
48BRSK20.37546433
49PRKCB0.37275899
50MTOR0.36509875
51TGFBR10.34393790
52FGFR10.34204727
53ERBB40.34069974
54CSNK2A10.33979038
55MAP4K20.33758116
56CSNK2A20.33485449
57INSRR0.33429377
58PTK20.32342835
59TIE10.31634346
60NUAK10.30057320
61CDK180.29905226
62CDK150.28340094
63FYN0.28173723
64PAK40.27763684
65FGFR20.26740489
66MAP3K100.25534750
67MAP3K40.25393128
68CSK0.25324763
69PRKCQ0.23797117
70STK30.23640516
71BCKDK0.23315178
72MET0.23244088
73EIF2AK10.22900672
74CHEK20.22116192
75CDK11A0.21935154
76KDR0.21498926
77MAPK100.20190766
78MST40.19774488
79SRC0.19750487
80TRIB30.19112163
81NEK20.18161344
82STK160.18129986
83CDK140.17155364
84ATM0.16935401
85CSNK1A10.16649702
86ADRBK20.16637233
87RPS6KB20.16460944
88AURKB0.16189279
89MAP2K70.15811799
90MYLK0.15340096
91LCK0.15268962
92NME10.14292213
93OBSCN0.13731177
94DYRK20.12941593
95OXSR10.11980366
96CDK10.11159145
97CDK30.11126791
98CHEK10.11114373
99STK380.11069949
100TESK20.10332805

Predicted pathways (KEGG)

RankGene SetZ-score
1Tyrosine metabolism_Homo sapiens_hsa003505.07876789
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.75049059
3Sulfur relay system_Homo sapiens_hsa041223.59574767
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.07209069
5Lysine degradation_Homo sapiens_hsa003102.75460134
6Ribosome_Homo sapiens_hsa030102.71095085
7RNA degradation_Homo sapiens_hsa030182.62169600
8DNA replication_Homo sapiens_hsa030302.37230850
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28433147
10Proteasome_Homo sapiens_hsa030502.13981450
11ErbB signaling pathway_Homo sapiens_hsa040122.08471504
12RNA transport_Homo sapiens_hsa030132.07768249
13Protein export_Homo sapiens_hsa030601.96089909
14Mismatch repair_Homo sapiens_hsa034301.89488039
15Graft-versus-host disease_Homo sapiens_hsa053321.77012075
16Selenocompound metabolism_Homo sapiens_hsa004501.74959152
17TGF-beta signaling pathway_Homo sapiens_hsa043501.74462743
18Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.74045217
19Regulation of autophagy_Homo sapiens_hsa041401.72532897
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.70874515
21Fatty acid metabolism_Homo sapiens_hsa012121.64872832
22mTOR signaling pathway_Homo sapiens_hsa041501.43780584
23Base excision repair_Homo sapiens_hsa034101.43293044
24Acute myeloid leukemia_Homo sapiens_hsa052211.42583392
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42169212
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41840012
27Glutathione metabolism_Homo sapiens_hsa004801.40288388
28Tight junction_Homo sapiens_hsa045301.35177855
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32443243
30Olfactory transduction_Homo sapiens_hsa047401.30671815
31Fatty acid elongation_Homo sapiens_hsa000621.27111352
32Pentose phosphate pathway_Homo sapiens_hsa000301.22557998
33Vitamin B6 metabolism_Homo sapiens_hsa007501.21388115
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17203137
35Longevity regulating pathway - mammal_Homo sapiens_hsa042111.13970415
36RNA polymerase_Homo sapiens_hsa030201.08829191
37Homologous recombination_Homo sapiens_hsa034401.05843337
38Antigen processing and presentation_Homo sapiens_hsa046120.98842413
39NF-kappa B signaling pathway_Homo sapiens_hsa040640.96957278
40Tryptophan metabolism_Homo sapiens_hsa003800.92440740
41HIF-1 signaling pathway_Homo sapiens_hsa040660.91384675
42Pyrimidine metabolism_Homo sapiens_hsa002400.89642712
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86253880
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.86178520
45Fanconi anemia pathway_Homo sapiens_hsa034600.86086007
46Protein digestion and absorption_Homo sapiens_hsa049740.82758042
47Biosynthesis of amino acids_Homo sapiens_hsa012300.81357026
48Non-homologous end-joining_Homo sapiens_hsa034500.80996740
49Fat digestion and absorption_Homo sapiens_hsa049750.79182425
50Spliceosome_Homo sapiens_hsa030400.78973748
51Propanoate metabolism_Homo sapiens_hsa006400.78646767
52Fatty acid degradation_Homo sapiens_hsa000710.78123691
53Steroid biosynthesis_Homo sapiens_hsa001000.76656879
54Parkinsons disease_Homo sapiens_hsa050120.76175574
55Choline metabolism in cancer_Homo sapiens_hsa052310.75675917
56Purine metabolism_Homo sapiens_hsa002300.73783842
57Cardiac muscle contraction_Homo sapiens_hsa042600.72716208
58One carbon pool by folate_Homo sapiens_hsa006700.72213381
59Oxidative phosphorylation_Homo sapiens_hsa001900.67298458
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66503725
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65596916
62Carbon metabolism_Homo sapiens_hsa012000.65155304
63mRNA surveillance pathway_Homo sapiens_hsa030150.61795673
64Peroxisome_Homo sapiens_hsa041460.61737416
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61618560
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60466556
67Glycerolipid metabolism_Homo sapiens_hsa005610.60046971
68Insulin resistance_Homo sapiens_hsa049310.58924127
69Cell cycle_Homo sapiens_hsa041100.58181543
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56748434
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55187065
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50388956
73Phototransduction_Homo sapiens_hsa047440.49595943
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49367401
75Butanoate metabolism_Homo sapiens_hsa006500.49280907
76Huntingtons disease_Homo sapiens_hsa050160.49188309
77AMPK signaling pathway_Homo sapiens_hsa041520.48749971
78Mineral absorption_Homo sapiens_hsa049780.47161743
79Caffeine metabolism_Homo sapiens_hsa002320.45659966
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44605903
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42769497
82Pyruvate metabolism_Homo sapiens_hsa006200.42377925
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38366002
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37300399
85Metabolic pathways_Homo sapiens_hsa011000.35459871
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35017040
87Dorso-ventral axis formation_Homo sapiens_hsa043200.34803576
88p53 signaling pathway_Homo sapiens_hsa041150.34346463
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34183772
90Epstein-Barr virus infection_Homo sapiens_hsa051690.32721218
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.32682858
92beta-Alanine metabolism_Homo sapiens_hsa004100.32156340
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31892744
94Chemical carcinogenesis_Homo sapiens_hsa052040.31543427
95Axon guidance_Homo sapiens_hsa043600.30716634
96Retinol metabolism_Homo sapiens_hsa008300.28443940
97Asthma_Homo sapiens_hsa053100.27581047
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26861864
99T cell receptor signaling pathway_Homo sapiens_hsa046600.26296811
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26285957

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