Rank | Gene Set | Z-score |
---|---|---|
1 | maturation of 5.8S rRNA (GO:0000460) | 9.73103610 |
2 | regulation of mitochondrial translation (GO:0070129) | 9.11356884 |
3 | positive regulation of signal transduction by p53 class mediator (GO:1901798) | 9.06381633 |
4 | regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253) | 8.49535469 |
5 | secretory granule organization (GO:0033363) | 8.17707851 |
6 | platelet formation (GO:0030220) | 7.18151507 |
7 | cytochrome complex assembly (GO:0017004) | 6.80677579 |
8 | negative regulation of translational initiation (GO:0045947) | 6.67219702 |
9 | negative regulation of signal transduction by p53 class mediator (GO:1901797) | 6.38063888 |
10 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230) | 5.69455152 |
11 | pseudouridine synthesis (GO:0001522) | 5.52437213 |
12 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.50426435 |
13 | regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516) | 5.45919678 |
14 | regulation of translation in response to stress (GO:0043555) | 5.25733248 |
15 | fusion of sperm to egg plasma membrane (GO:0007342) | 4.98958933 |
16 | regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902229) | 4.77286478 |
17 | positive regulation of macrophage differentiation (GO:0045651) | 4.55820367 |
18 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 4.42864339 |
19 | myeloid cell development (GO:0061515) | 4.35354951 |
20 | glucose 6-phosphate metabolic process (GO:0051156) | 4.27434988 |
21 | regulation of translational initiation (GO:0006446) | 4.26890163 |
22 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.26189127 |
23 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.26189127 |
24 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 4.04498840 |
25 | regulation of B cell differentiation (GO:0045577) | 4.00516189 |
26 | protein complex biogenesis (GO:0070271) | 3.89371979 |
27 | regulation of signal transduction by p53 class mediator (GO:1901796) | 3.89149117 |
28 | negative regulation of membrane potential (GO:0045837) | 3.88200362 |
29 | piRNA metabolic process (GO:0034587) | 3.84168718 |
30 | regulation of nucleobase-containing compound transport (GO:0032239) | 3.82406331 |
31 | plasma membrane fusion (GO:0045026) | 3.79566796 |
32 | ribosomal small subunit biogenesis (GO:0042274) | 3.76757667 |
33 | regulation of necrotic cell death (GO:0010939) | 3.75938993 |
34 | T cell apoptotic process (GO:0070231) | 3.73640088 |
35 | ribosomal small subunit assembly (GO:0000028) | 3.71249128 |
36 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.71146795 |
37 | cellular protein catabolic process (GO:0044257) | 3.69959648 |
38 | production of molecular mediator involved in inflammatory response (GO:0002532) | 3.68411145 |
39 | erythrocyte maturation (GO:0043249) | 3.67084483 |
40 | positive regulation of translation (GO:0045727) | 3.65423069 |
41 | regulation of epidermal growth factor-activated receptor activity (GO:0007176) | 3.62265030 |
42 | negative regulation of chemokine production (GO:0032682) | 3.53868069 |
43 | positive regulation of fat cell differentiation (GO:0045600) | 3.53238890 |
44 | inner mitochondrial membrane organization (GO:0007007) | 3.48890849 |
45 | positive regulation of response to DNA damage stimulus (GO:2001022) | 3.48010547 |
46 | negative regulation of response to DNA damage stimulus (GO:2001021) | 3.46743902 |
47 | regulation of necroptotic process (GO:0060544) | 3.46496284 |
48 | determination of adult lifespan (GO:0008340) | 3.44486824 |
49 | protein kinase B signaling (GO:0043491) | 3.40136840 |
50 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.39982504 |
51 | respiratory chain complex IV assembly (GO:0008535) | 3.37730099 |
52 | necroptotic process (GO:0070266) | 3.37010082 |
53 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 3.32190097 |
54 | positive regulation of mast cell degranulation (GO:0043306) | 3.32190097 |
55 | fibril organization (GO:0097435) | 3.27148801 |
56 | rRNA modification (GO:0000154) | 3.25311896 |
57 | response to food (GO:0032094) | 3.09917321 |
58 | lymphocyte apoptotic process (GO:0070227) | 3.08235931 |
59 | NADPH regeneration (GO:0006740) | 3.04497323 |
60 | histone H4-K12 acetylation (GO:0043983) | 3.03480578 |
61 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 2.96101227 |
62 | DNA packaging (GO:0006323) | 2.95863625 |
63 | ubiquinone biosynthetic process (GO:0006744) | 2.90564628 |
64 | lamellipodium assembly (GO:0030032) | 2.82119727 |
65 | L-serine metabolic process (GO:0006563) | 2.82116341 |
66 | regulation of translation (GO:0006417) | 2.79497845 |
67 | regulation of telomere maintenance via telomerase (GO:0032210) | 2.77441562 |
68 | neural tube formation (GO:0001841) | 2.75667001 |
69 | regulation of chemokine biosynthetic process (GO:0045073) | 2.74921973 |
70 | viral transcription (GO:0019083) | 2.70664685 |
71 | oligodendrocyte development (GO:0014003) | 2.66984879 |
72 | translational termination (GO:0006415) | 2.66623828 |
73 | formation of translation preinitiation complex (GO:0001731) | 2.66550846 |
74 | heterochromatin organization (GO:0070828) | 2.66165218 |
75 | translational initiation (GO:0006413) | 2.64219507 |
76 | ubiquinone metabolic process (GO:0006743) | 2.64096658 |
77 | sequestering of extracellular ligand from receptor (GO:0035581) | 2.63059940 |
78 | pentose-phosphate shunt (GO:0006098) | 2.61850917 |
79 | purine ribonucleotide transport (GO:0015868) | 2.60930442 |
80 | positive regulation of mitochondrial membrane permeability (GO:0035794) | 2.60814057 |
81 | regulation of memory T cell differentiation (GO:0043380) | 2.57194177 |
82 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 2.56213730 |
83 | regulation of oxidative phosphorylation (GO:0002082) | 2.52584310 |
84 | lipoxygenase pathway (GO:0019372) | 2.52219173 |
85 | cellular response to interferon-beta (GO:0035458) | 2.50641036 |
86 | chromatin assembly (GO:0031497) | 2.47991917 |
87 | adenine nucleotide transport (GO:0051503) | 2.46861048 |
88 | regulation of macrophage differentiation (GO:0045649) | 2.44830826 |
89 | positive regulation of mast cell activation (GO:0033005) | 2.43790069 |
90 | DNA integration (GO:0015074) | 2.42906181 |
91 | lamellipodium organization (GO:0097581) | 2.41567088 |
92 | positive regulation of myeloid leukocyte mediated immunity (GO:0002888) | 2.39229324 |
93 | RNA localization (GO:0006403) | 15.6278314 |
94 | signal complex assembly (GO:0007172) | 12.5355841 |
95 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class | 12.2123782 |
96 | positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517) | 11.3550521 |
97 | regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 10.3466224 |
98 | positive regulation of translational initiation (GO:0045948) | 10.3353530 |
99 | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254) | 10.3025720 |
100 | megakaryocyte development (GO:0035855) | 10.2642547 |
Rank | Gene Set | Z-score |
---|---|---|
1 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 7.81794975 |
2 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.95099481 |
3 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 3.66180493 |
4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.50148836 |
5 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.25977550 |
6 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.88024919 |
7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.87512357 |
8 | TP53_16413492_ChIP-PET_HCT116_Human | 2.81926977 |
9 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.67150711 |
10 | EGR1_19032775_ChIP-ChIP_M12_Human | 2.60298527 |
11 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.55250760 |
12 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 2.45345401 |
13 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.41530685 |
14 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 2.28824980 |
15 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.26484497 |
16 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.22758071 |
17 | VDR_22108803_ChIP-Seq_LS180_Human | 2.21292345 |
18 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.13819687 |
19 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.07632419 |
20 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.06618088 |
21 | TBX3_20139965_ChIP-Seq_ESCs_Mouse | 2.02155996 |
22 | TBX3_20139965_ChIP-Seq_MESCs_Mouse | 2.00216112 |
23 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.97486624 |
24 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.93710214 |
25 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.91674597 |
26 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.91361333 |
27 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.81832594 |
28 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.80408639 |
29 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.77785413 |
30 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.77229522 |
31 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.77029989 |
32 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.72710803 |
33 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.72521163 |
34 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.71906149 |
35 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.71281423 |
36 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.69850405 |
37 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.65127299 |
38 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.64882450 |
39 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.62523415 |
40 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.62340669 |
41 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.59390286 |
42 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.58106106 |
43 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.55537115 |
44 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.55059384 |
45 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.52425991 |
46 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.50543113 |
47 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.49775041 |
48 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.46844918 |
49 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.46708145 |
50 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.46580751 |
51 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.44499990 |
52 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 1.37008745 |
53 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.36222627 |
54 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.31632630 |
55 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.28684935 |
56 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.28463882 |
57 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.27599702 |
58 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.27599702 |
59 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.27599702 |
60 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.26461770 |
61 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.19883777 |
62 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.18575127 |
63 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.18220727 |
64 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.18180464 |
65 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.17850165 |
66 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.17648037 |
67 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.16519644 |
68 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.13008941 |
69 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.10272814 |
70 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.09728014 |
71 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.09265316 |
72 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.08094517 |
73 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.06874616 |
74 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.05202604 |
75 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 1.04902605 |
76 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.00644123 |
77 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.00519641 |
78 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.98117807 |
79 | TTF2_22483619_ChIP-Seq_HELA_Human | 0.97814105 |
80 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.97706103 |
81 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.97044299 |
82 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.96988149 |
83 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 0.96020026 |
84 | SETDB1_19884257_ChIP-Seq_MESCs_Mouse | 0.95030694 |
85 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.94799785 |
86 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.94492190 |
87 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.91654883 |
88 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.90975469 |
89 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 0.89385260 |
90 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.88039687 |
91 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.87702682 |
92 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.87355428 |
93 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.84114107 |
94 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.83910848 |
95 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.82779864 |
96 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.80763497 |
97 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.80037999 |
98 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.79838092 |
99 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.79792786 |
100 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.78572831 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003646_muscle_fatigue | 5.77680252 |
2 | MP0006292_abnormal_olfactory_placode | 3.86007692 |
3 | MP0004147_increased_porphyrin_level | 3.64557310 |
4 | MP0006035_abnormal_mitochondrial_morpho | 3.42712044 |
5 | MP0004957_abnormal_blastocyst_morpholog | 3.39203417 |
6 | MP0001661_extended_life_span | 3.31974284 |
7 | MP0005503_abnormal_tendon_morphology | 3.30668965 |
8 | MP0002277_abnormal_respiratory_mucosa | 2.87663344 |
9 | MP0008877_abnormal_DNA_methylation | 2.85230971 |
10 | MP0005410_abnormal_fertilization | 2.76683785 |
11 | MP0004145_abnormal_muscle_electrophysio | 2.60576821 |
12 | MP0002938_white_spotting | 2.49108060 |
13 | MP0003941_abnormal_skin_development | 2.35971649 |
14 | MP0000579_abnormal_nail_morphology | 2.25696227 |
15 | MP0008058_abnormal_DNA_repair | 2.20848893 |
16 | MP0003693_abnormal_embryo_hatching | 2.15662293 |
17 | MP0010094_abnormal_chromosome_stability | 2.11751111 |
18 | MP0000462_abnormal_digestive_system | 2.05401020 |
19 | MP0003111_abnormal_nucleus_morphology | 1.99199881 |
20 | MP0000372_irregular_coat_pigmentation | 1.91121766 |
21 | MP0002254_reproductive_system_inflammat | 1.90805050 |
22 | MP0008932_abnormal_embryonic_tissue | 1.83258603 |
23 | MP0005084_abnormal_gallbladder_morpholo | 1.78988232 |
24 | MP0003718_maternal_effect | 1.68493634 |
25 | MP0009672_abnormal_birth_weight | 1.64966500 |
26 | MP0003195_calcinosis | 1.62427013 |
27 | MP0005083_abnormal_biliary_tract | 1.60195240 |
28 | MP0003937_abnormal_limbs/digits/tail_de | 1.51789832 |
29 | MP0000358_abnormal_cell_content/ | 1.43173865 |
30 | MP0010030_abnormal_orbit_morphology | 1.36864954 |
31 | MP0003436_decreased_susceptibility_to | 1.34725218 |
32 | MP0002108_abnormal_muscle_morphology | 1.34444588 |
33 | MP0006072_abnormal_retinal_apoptosis | 1.33555400 |
34 | MP0001727_abnormal_embryo_implantation | 1.33277580 |
35 | MP0004133_heterotaxia | 1.33026740 |
36 | MP0004215_abnormal_myocardial_fiber | 1.25701504 |
37 | MP0003119_abnormal_digestive_system | 1.23491838 |
38 | MP0009250_abnormal_appendicular_skeleto | 1.22180007 |
39 | MP0002736_abnormal_nociception_after | 1.20400504 |
40 | MP0000566_synostosis | 1.17159232 |
41 | MP0002102_abnormal_ear_morphology | 1.17075159 |
42 | MP0003077_abnormal_cell_cycle | 1.12890117 |
43 | MP0000534_abnormal_ureter_morphology | 1.08713507 |
44 | MP0003137_abnormal_impulse_conducting | 1.07202903 |
45 | MP0001243_abnormal_dermal_layer | 1.04683913 |
46 | MP0001293_anophthalmia | 1.00809171 |
47 | MP0009697_abnormal_copulation | 1.00419887 |
48 | MP0000639_abnormal_adrenal_gland | 0.97563521 |
49 | MP0008995_early_reproductive_senescence | 0.97046670 |
50 | MP0004130_abnormal_muscle_cell | 0.96638651 |
51 | MP0002697_abnormal_eye_size | 0.93425794 |
52 | MP0000631_abnormal_neuroendocrine_gland | 0.92495811 |
53 | MP0003567_abnormal_fetal_cardiomyocyte | 0.88713815 |
54 | MP0010307_abnormal_tumor_latency | 0.88218826 |
55 | MP0003136_yellow_coat_color | 0.87985887 |
56 | MP0002751_abnormal_autonomic_nervous | 0.86864016 |
57 | MP0009764_decreased_sensitivity_to | 0.86774799 |
58 | MP0001529_abnormal_vocalization | 0.86202037 |
59 | MP0006276_abnormal_autonomic_nervous | 0.85977058 |
60 | MP0008789_abnormal_olfactory_epithelium | 0.84648497 |
61 | MP0001286_abnormal_eye_development | 0.84222354 |
62 | MP0000751_myopathy | 0.83016667 |
63 | MP0001697_abnormal_embryo_size | 0.82370977 |
64 | MP0008004_abnormal_stomach_pH | 0.81657403 |
65 | MP0005187_abnormal_penis_morphology | 0.81455549 |
66 | MP0005332_abnormal_amino_acid | 0.78977354 |
67 | MP0002085_abnormal_embryonic_tissue | 0.77755153 |
68 | MP0002089_abnormal_postnatal_growth/wei | 0.77264034 |
69 | MP0003938_abnormal_ear_development | 0.74877140 |
70 | MP0003315_abnormal_perineum_morphology | 0.72862231 |
71 | MP0006036_abnormal_mitochondrial_physio | 0.72223383 |
72 | MP0006054_spinal_hemorrhage | 0.71822685 |
73 | MP0004185_abnormal_adipocyte_glucose | 0.71214949 |
74 | MP0000049_abnormal_middle_ear | 0.71047134 |
75 | MP0009046_muscle_twitch | 0.70458339 |
76 | MP0001730_embryonic_growth_arrest | 0.70303783 |
77 | MP0005647_abnormal_sex_gland | 0.70302452 |
78 | MP0003880_abnormal_central_pattern | 0.69568131 |
79 | MP0002160_abnormal_reproductive_system | 0.69128395 |
80 | MP0002169_no_abnormal_phenotype | 0.68669581 |
81 | MP0002873_normal_phenotype | 0.67739929 |
82 | MP0009703_decreased_birth_body | 0.67240412 |
83 | MP0002111_abnormal_tail_morphology | 0.66886084 |
84 | MP0008057_abnormal_DNA_replication | 0.66516715 |
85 | MP0008260_abnormal_autophagy | 0.66188898 |
86 | MP0001968_abnormal_touch/_nociception | 0.63208689 |
87 | MP0001346_abnormal_lacrimal_gland | 0.62882266 |
88 | MP0005499_abnormal_olfactory_system | 0.62471271 |
89 | MP0005394_taste/olfaction_phenotype | 0.62471271 |
90 | MP0002971_abnormal_brown_adipose | 0.61165071 |
91 | MP0002084_abnormal_developmental_patter | 0.60239615 |
92 | MP0001666_abnormal_nutrient_absorption | 0.59047418 |
93 | MP0002233_abnormal_nose_morphology | 0.58975599 |
94 | MP0003787_abnormal_imprinting | 0.57361638 |
95 | MP0003122_maternal_imprinting | 0.56867227 |
96 | MP0001119_abnormal_female_reproductive | 0.56452722 |
97 | MP0002796_impaired_skin_barrier | 0.56049004 |
98 | MP0003698_abnormal_male_reproductive | 0.56000358 |
99 | MP0002210_abnormal_sex_determination | 0.55585488 |
100 | MP0005646_abnormal_pituitary_gland | 0.55415822 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Cerebral hypomyelination (HP:0006808) | 8.12590372 |
2 | Premature ovarian failure (HP:0008209) | 5.32019541 |
3 | Secondary amenorrhea (HP:0000869) | 4.72567218 |
4 | Delusions (HP:0000746) | 4.59100209 |
5 | Carpal bone hypoplasia (HP:0001498) | 4.53348457 |
6 | Small epiphyses (HP:0010585) | 4.37540549 |
7 | Concave nail (HP:0001598) | 4.13362344 |
8 | Oral leukoplakia (HP:0002745) | 4.10361958 |
9 | IgM deficiency (HP:0002850) | 3.94751352 |
10 | Postnatal microcephaly (HP:0005484) | 3.90981984 |
11 | Aplastic anemia (HP:0001915) | 3.62074760 |
12 | Personality changes (HP:0000751) | 3.56075056 |
13 | CNS hypomyelination (HP:0003429) | 3.56047690 |
14 | Bifid tongue (HP:0010297) | 3.38501988 |
15 | Unsteady gait (HP:0002317) | 3.36098211 |
16 | Facial diplegia (HP:0001349) | 3.16078421 |
17 | Abnormal number of incisors (HP:0011064) | 3.14564775 |
18 | Multiple enchondromatosis (HP:0005701) | 3.11573871 |
19 | Abnormality of the labia minora (HP:0012880) | 3.10231585 |
20 | Rough bone trabeculation (HP:0100670) | 3.04259143 |
21 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 3.02412576 |
22 | Aplasia of the musculature (HP:0100854) | 2.93712783 |
23 | Abnormal lung lobation (HP:0002101) | 2.90430459 |
24 | Colon cancer (HP:0003003) | 2.83770549 |
25 | Septo-optic dysplasia (HP:0100842) | 2.81955646 |
26 | Irregular epiphyses (HP:0010582) | 2.73693126 |
27 | Agitation (HP:0000713) | 2.73594552 |
28 | Abnormality of cochlea (HP:0000375) | 2.61207355 |
29 | Macrocytic anemia (HP:0001972) | 2.58330648 |
30 | Asplenia (HP:0001746) | 2.55426665 |
31 | Reticulocytosis (HP:0001923) | 2.52616942 |
32 | Testicular atrophy (HP:0000029) | 2.48913334 |
33 | Pendular nystagmus (HP:0012043) | 2.48580335 |
34 | Cellular immunodeficiency (HP:0005374) | 2.48353262 |
35 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 2.46771988 |
36 | Adrenal hypoplasia (HP:0000835) | 2.45002144 |
37 | Alveolar cell carcinoma (HP:0006519) | 2.44187288 |
38 | Abnormality of chromosome stability (HP:0003220) | 2.39453784 |
39 | Abnormality of reticulocytes (HP:0004312) | 2.38912134 |
40 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.36696750 |
41 | Abnormal trabecular bone morphology (HP:0100671) | 2.35654467 |
42 | Prolonged neonatal jaundice (HP:0006579) | 2.33055335 |
43 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.26565442 |
44 | Short hallux (HP:0010109) | 2.23354683 |
45 | Meckel diverticulum (HP:0002245) | 2.23192446 |
46 | Median cleft lip (HP:0000161) | 2.22727917 |
47 | Birth length less than 3rd percentile (HP:0003561) | 2.20588195 |
48 | Pterygium (HP:0001059) | 2.20554925 |
49 | Hyperglycinemia (HP:0002154) | 2.17789618 |
50 | Triphalangeal thumb (HP:0001199) | 2.16746686 |
51 | Horseshoe kidney (HP:0000085) | 2.16599294 |
52 | Central scotoma (HP:0000603) | 2.15322856 |
53 | Pancytopenia (HP:0001876) | 2.14467124 |
54 | Scotoma (HP:0000575) | 2.13862432 |
55 | Neoplasm of the tracheobronchial system (HP:0100552) | 2.13843055 |
56 | Reticulocytopenia (HP:0001896) | 2.09979760 |
57 | Ileus (HP:0002595) | 2.08455324 |
58 | Pallor (HP:0000980) | 2.07556372 |
59 | Patellar aplasia (HP:0006443) | 2.06750308 |
60 | Abnormality of the ileum (HP:0001549) | 2.06161973 |
61 | Epiphyseal dysplasia (HP:0002656) | 2.05801008 |
62 | Aplasia/Hypoplasia of the hallux (HP:0008362) | 2.03833820 |
63 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.03574858 |
64 | Delayed epiphyseal ossification (HP:0002663) | 1.99337162 |
65 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 1.98709667 |
66 | Chromsome breakage (HP:0040012) | 1.97933262 |
67 | Morphological abnormality of the inner ear (HP:0011390) | 1.95301749 |
68 | Absent phalangeal crease (HP:0006109) | 1.94790438 |
69 | Restlessness (HP:0000711) | 1.93370284 |
70 | CNS demyelination (HP:0007305) | 1.92608441 |
71 | Tracheoesophageal fistula (HP:0002575) | 1.91694268 |
72 | Absent septum pellucidum (HP:0001331) | 1.90610016 |
73 | Breast aplasia (HP:0100783) | 1.90082576 |
74 | Premature graying of hair (HP:0002216) | 1.89318271 |
75 | Increased hepatocellular lipid droplets (HP:0006565) | 1.88907424 |
76 | Hyperbilirubinemia (HP:0002904) | 1.88893406 |
77 | Hypoplastic pelvis (HP:0008839) | 1.88404428 |
78 | Poor speech (HP:0002465) | 1.86045810 |
79 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.84050340 |
80 | Stenosis of the external auditory canal (HP:0000402) | 1.83799763 |
81 | Abnormality of serum amino acid levels (HP:0003112) | 1.82918227 |
82 | Increased corneal curvature (HP:0100692) | 1.82604397 |
83 | Keratoconus (HP:0000563) | 1.82604397 |
84 | Mild short stature (HP:0003502) | 1.79176138 |
85 | Facial cleft (HP:0002006) | 1.78764343 |
86 | Sudden death (HP:0001699) | 1.78759891 |
87 | Impaired proprioception (HP:0010831) | 1.76853210 |
88 | Abnormal finger flexion creases (HP:0006143) | 1.75503543 |
89 | Abnormality of the preputium (HP:0100587) | 1.75196044 |
90 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 1.75047271 |
91 | Abnormality of glycine metabolism (HP:0010895) | 1.73915273 |
92 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.73915273 |
93 | Methylmalonic acidemia (HP:0002912) | 1.73627801 |
94 | Abnormality of the middle phalanges of the toes (HP:0010183) | 1.72561462 |
95 | Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376) | 1.71772030 |
96 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 1.70847468 |
97 | Selective tooth agenesis (HP:0001592) | 1.64057612 |
98 | Emotional lability (HP:0000712) | 1.63020071 |
99 | Abnormality of the duodenum (HP:0002246) | 1.62155507 |
100 | Short tibia (HP:0005736) | 1.59452040 |
Rank | Gene Set | Z-score |
---|---|---|
1 | PRKCI | 3.82584652 |
2 | BMPR2 | 3.60901478 |
3 | EIF2AK3 | 2.96654179 |
4 | NEK1 | 2.41614865 |
5 | MAP4K1 | 2.25183602 |
6 | RIPK1 | 13.3984271 |
7 | PASK | 1.91639710 |
8 | ZAK | 1.80499784 |
9 | MAPKAPK3 | 1.74494654 |
10 | DAPK3 | 1.72192149 |
11 | PRKCG | 1.67424263 |
12 | PDPK1 | 1.54567806 |
13 | TTK | 1.35010175 |
14 | YES1 | 1.26162582 |
15 | TSSK6 | 1.25315510 |
16 | PRKCE | 1.24592452 |
17 | CDC7 | 1.24155304 |
18 | STK38L | 1.23857734 |
19 | STK24 | 1.15984629 |
20 | PLK4 | 1.10801577 |
21 | WNK3 | 1.05486969 |
22 | FGR | 1.03361465 |
23 | BUB1 | 1.00902673 |
24 | PLK3 | 0.99959979 |
25 | TNIK | 0.95767689 |
26 | MKNK2 | 0.86698339 |
27 | TRIM28 | 0.84721645 |
28 | FLT3 | 0.82686969 |
29 | DAPK1 | 0.78261764 |
30 | PRKCZ | 0.75407532 |
31 | MKNK1 | 0.74999988 |
32 | EPHA4 | 0.71571423 |
33 | PRKCD | 0.69448587 |
34 | VRK2 | 0.68832179 |
35 | NTRK1 | 0.62743969 |
36 | WEE1 | 0.62380827 |
37 | DYRK3 | 0.59979185 |
38 | PLK1 | 0.54516251 |
39 | CLK1 | 0.53731583 |
40 | PBK | 0.53657346 |
41 | SRPK1 | 0.50842649 |
42 | STK4 | 0.45032293 |
43 | GRK1 | 0.43062595 |
44 | ATR | 0.41844613 |
45 | VRK1 | 0.40752302 |
46 | EIF2AK2 | 0.38767469 |
47 | BMPR1B | 0.38678482 |
48 | BRSK2 | 0.37546433 |
49 | PRKCB | 0.37275899 |
50 | MTOR | 0.36509875 |
51 | TGFBR1 | 0.34393790 |
52 | FGFR1 | 0.34204727 |
53 | ERBB4 | 0.34069974 |
54 | CSNK2A1 | 0.33979038 |
55 | MAP4K2 | 0.33758116 |
56 | CSNK2A2 | 0.33485449 |
57 | INSRR | 0.33429377 |
58 | PTK2 | 0.32342835 |
59 | TIE1 | 0.31634346 |
60 | NUAK1 | 0.30057320 |
61 | CDK18 | 0.29905226 |
62 | CDK15 | 0.28340094 |
63 | FYN | 0.28173723 |
64 | PAK4 | 0.27763684 |
65 | FGFR2 | 0.26740489 |
66 | MAP3K10 | 0.25534750 |
67 | MAP3K4 | 0.25393128 |
68 | CSK | 0.25324763 |
69 | PRKCQ | 0.23797117 |
70 | STK3 | 0.23640516 |
71 | BCKDK | 0.23315178 |
72 | MET | 0.23244088 |
73 | EIF2AK1 | 0.22900672 |
74 | CHEK2 | 0.22116192 |
75 | CDK11A | 0.21935154 |
76 | KDR | 0.21498926 |
77 | MAPK10 | 0.20190766 |
78 | MST4 | 0.19774488 |
79 | SRC | 0.19750487 |
80 | TRIB3 | 0.19112163 |
81 | NEK2 | 0.18161344 |
82 | STK16 | 0.18129986 |
83 | CDK14 | 0.17155364 |
84 | ATM | 0.16935401 |
85 | CSNK1A1 | 0.16649702 |
86 | ADRBK2 | 0.16637233 |
87 | RPS6KB2 | 0.16460944 |
88 | AURKB | 0.16189279 |
89 | MAP2K7 | 0.15811799 |
90 | MYLK | 0.15340096 |
91 | LCK | 0.15268962 |
92 | NME1 | 0.14292213 |
93 | OBSCN | 0.13731177 |
94 | DYRK2 | 0.12941593 |
95 | OXSR1 | 0.11980366 |
96 | CDK1 | 0.11159145 |
97 | CDK3 | 0.11126791 |
98 | CHEK1 | 0.11114373 |
99 | STK38 | 0.11069949 |
100 | TESK2 | 0.10332805 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Tyrosine metabolism_Homo sapiens_hsa00350 | 5.07876789 |
2 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 3.75049059 |
3 | Sulfur relay system_Homo sapiens_hsa04122 | 3.59574767 |
4 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 3.07209069 |
5 | Lysine degradation_Homo sapiens_hsa00310 | 2.75460134 |
6 | Ribosome_Homo sapiens_hsa03010 | 2.71095085 |
7 | RNA degradation_Homo sapiens_hsa03018 | 2.62169600 |
8 | DNA replication_Homo sapiens_hsa03030 | 2.37230850 |
9 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.28433147 |
10 | Proteasome_Homo sapiens_hsa03050 | 2.13981450 |
11 | ErbB signaling pathway_Homo sapiens_hsa04012 | 2.08471504 |
12 | RNA transport_Homo sapiens_hsa03013 | 2.07768249 |
13 | Protein export_Homo sapiens_hsa03060 | 1.96089909 |
14 | Mismatch repair_Homo sapiens_hsa03430 | 1.89488039 |
15 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.77012075 |
16 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.74959152 |
17 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.74462743 |
18 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 1.74045217 |
19 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.72532897 |
20 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.70874515 |
21 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.64872832 |
22 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.43780584 |
23 | Base excision repair_Homo sapiens_hsa03410 | 1.43293044 |
24 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.42583392 |
25 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.42169212 |
26 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.41840012 |
27 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.40288388 |
28 | Tight junction_Homo sapiens_hsa04530 | 1.35177855 |
29 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.32443243 |
30 | Olfactory transduction_Homo sapiens_hsa04740 | 1.30671815 |
31 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.27111352 |
32 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.22557998 |
33 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.21388115 |
34 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.17203137 |
35 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 1.13970415 |
36 | RNA polymerase_Homo sapiens_hsa03020 | 1.08829191 |
37 | Homologous recombination_Homo sapiens_hsa03440 | 1.05843337 |
38 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.98842413 |
39 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.96957278 |
40 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.92440740 |
41 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.91384675 |
42 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.89642712 |
43 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.86253880 |
44 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.86178520 |
45 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.86086007 |
46 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.82758042 |
47 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.81357026 |
48 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.80996740 |
49 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.79182425 |
50 | Spliceosome_Homo sapiens_hsa03040 | 0.78973748 |
51 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.78646767 |
52 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.78123691 |
53 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.76656879 |
54 | Parkinsons disease_Homo sapiens_hsa05012 | 0.76175574 |
55 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.75675917 |
56 | Purine metabolism_Homo sapiens_hsa00230 | 0.73783842 |
57 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.72716208 |
58 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.72213381 |
59 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.67298458 |
60 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.66503725 |
61 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.65596916 |
62 | Carbon metabolism_Homo sapiens_hsa01200 | 0.65155304 |
63 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.61795673 |
64 | Peroxisome_Homo sapiens_hsa04146 | 0.61737416 |
65 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.61618560 |
66 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.60466556 |
67 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.60046971 |
68 | Insulin resistance_Homo sapiens_hsa04931 | 0.58924127 |
69 | Cell cycle_Homo sapiens_hsa04110 | 0.58181543 |
70 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.56748434 |
71 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.55187065 |
72 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.50388956 |
73 | Phototransduction_Homo sapiens_hsa04744 | 0.49595943 |
74 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.49367401 |
75 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.49280907 |
76 | Huntingtons disease_Homo sapiens_hsa05016 | 0.49188309 |
77 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.48749971 |
78 | Mineral absorption_Homo sapiens_hsa04978 | 0.47161743 |
79 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.45659966 |
80 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.44605903 |
81 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.42769497 |
82 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.42377925 |
83 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.38366002 |
84 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.37300399 |
85 | Metabolic pathways_Homo sapiens_hsa01100 | 0.35459871 |
86 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.35017040 |
87 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.34803576 |
88 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.34346463 |
89 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.34183772 |
90 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.32721218 |
91 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.32682858 |
92 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.32156340 |
93 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.31892744 |
94 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.31543427 |
95 | Axon guidance_Homo sapiens_hsa04360 | 0.30716634 |
96 | Retinol metabolism_Homo sapiens_hsa00830 | 0.28443940 |
97 | Asthma_Homo sapiens_hsa05310 | 0.27581047 |
98 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.26861864 |
99 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.26296811 |
100 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.26285957 |