ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA strand elongation involved in DNA replication (GO:0006271)	5.52545670
2	telomere maintenance via semi-conservative replication (GO:0032201)	5.47710002
3	DNA strand elongation (GO:0022616)	5.33329400
4	DNA replication checkpoint (GO:0000076)	5.32206751
5	telomere maintenance via recombination (GO:0000722)	4.65232882
6	DNA double-strand break processing (GO:0000729)	4.58064794
7	mitotic recombination (GO:0006312)	4.27799469
8	CENP-A containing nucleosome assembly (GO:0034080)	4.07679616
9	chromatin remodeling at centromere (GO:0031055)	4.03740197
10	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.90286661
11	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.90286661
12	ribosomal small subunit biogenesis (GO:0042274)	3.88691285
13	telomere maintenance via telomere lengthening (GO:0010833)	3.85384384
14	rRNA modification (GO:0000154)	3.79337543
15	translesion synthesis (GO:0019985)	3.65346520
16	ribosomal small subunit assembly (GO:0000028)	3.58814280
17	rRNA methylation (GO:0031167)	3.56870057
18	establishment of integrated proviral latency (GO:0075713)	3.54549781
19	L-serine metabolic process (GO:0006563)	3.54157190
20	base-excision repair (GO:0006284)	3.53128762
21	DNA unwinding involved in DNA replication (GO:0006268)	3.51881704
22	formation of translation preinitiation complex (GO:0001731)	3.51817219
23	chaperone-mediated protein transport (GO:0072321)	3.50128185
24	ribosomal large subunit biogenesis (GO:0042273)	3.46749620
25	histone exchange (GO:0043486)	3.45808210
26	DNA replication-independent nucleosome organization (GO:0034724)	3.43803963
27	DNA replication-independent nucleosome assembly (GO:0006336)	3.43803963
28	mitochondrial DNA replication (GO:0006264)	3.42995355
29	viral transcription (GO:0019083)	3.42492243
30	DNA replication initiation (GO:0006270)	3.42169901
31	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.39766630
32	DNA replication-dependent nucleosome organization (GO:0034723)	3.35090900
33	DNA replication-dependent nucleosome assembly (GO:0006335)	3.35090900
34	maturation of SSU-rRNA (GO:0030490)	3.33457176
35	mitotic chromosome condensation (GO:0007076)	3.33135842
36	translational termination (GO:0006415)	3.32498245
37	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.28463179
38	purine nucleobase biosynthetic process (GO:0009113)	3.25943391
39	ribonucleoprotein complex biogenesis (GO:0022613)	3.21532985
40	ribosome assembly (GO:0042255)	3.20051418
41	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.19997310
42	DNA catabolic process, exonucleolytic (GO:0000738)	3.18386589
43	nucleobase-containing small molecule interconversion (GO:0015949)	3.18300234
44	spliceosomal snRNP assembly (GO:0000387)	3.17196022
45	positive regulation of DNA-dependent DNA replication (GO:2000105)	3.14366747
46	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.13513055
47	IMP biosynthetic process (GO:0006188)	3.13458544
48	translational elongation (GO:0006414)	3.13455931
49	nucleobase biosynthetic process (GO:0046112)	3.10319509
50	regulation of helicase activity (GO:0051095)	3.09384376
51	regulation of centriole replication (GO:0046599)	3.04487347
52	protein localization to kinetochore (GO:0034501)	3.03801656
53	mitotic metaphase plate congression (GO:0007080)	3.03350969
54	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.00354392
55	mitochondrial DNA metabolic process (GO:0032042)	2.99898505
56	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.98827053
57	synapsis (GO:0007129)	2.98040829
58	kinetochore organization (GO:0051383)	2.96602056
59	postreplication repair (GO:0006301)	2.96519705
60	ribosome biogenesis (GO:0042254)	2.96093141
61	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.95527831
62	regulation of translational fidelity (GO:0006450)	2.94988391
63	regulation of DNA endoreduplication (GO:0032875)	2.94668837
64	serine family amino acid biosynthetic process (GO:0009070)	2.94191210
65	translational initiation (GO:0006413)	2.93440160
66	cotranslational protein targeting to membrane (GO:0006613)	2.93229710
67	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.91358995
68	protein targeting to ER (GO:0045047)	2.89642636
69	proteasome assembly (GO:0043248)	2.89140222
70	rRNA processing (GO:0006364)	2.87041869
71	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.86614971
72	telomere maintenance (GO:0000723)	2.84670469
73	cellular component biogenesis (GO:0044085)	2.84452903
74	folic acid-containing compound biosynthetic process (GO:0009396)	2.84247039
75	telomere organization (GO:0032200)	2.83347090
76	DNA-dependent DNA replication (GO:0006261)	2.82688133
77	rRNA transcription (GO:0009303)	2.82225939
78	deoxyribonucleotide biosynthetic process (GO:0009263)	2.81447466
79	transcription-coupled nucleotide-excision repair (GO:0006283)	2.80784404
80	protein localization to endoplasmic reticulum (GO:0070972)	2.79697903
81	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.78900305
82	protein neddylation (GO:0045116)	2.78802229
83	cell cycle G1/S phase transition (GO:0044843)	2.74464712
84	G1/S transition of mitotic cell cycle (GO:0000082)	2.74464712
85	chromosome condensation (GO:0030261)	2.74173204
86	protein localization to chromosome, centromeric region (GO:0071459)	2.73990434
87	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	2.73243840
88	rRNA metabolic process (GO:0016072)	2.71572384
89	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.71559093
90	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.71175176
91	IMP metabolic process (GO:0046040)	2.70515351
92	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.70055811
93	establishment of viral latency (GO:0019043)	2.69824341
94	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.69760807
95	translation (GO:0006412)	2.69746547
96	chromatin assembly or disassembly (GO:0006333)	2.69158319
97	CTP metabolic process (GO:0046036)	2.68751267
98	CTP biosynthetic process (GO:0006241)	2.68751267
99	deoxyribose phosphate biosynthetic process (GO:0046385)	2.67562391
100	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.67562391

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	8.35586572
2	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.62318645
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.89342561
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.48546315
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.41006741
6	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.33143726
7	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.29116806
8	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.19945457
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.16678916
10	MYC_18358816_ChIP-ChIP_MESCs_Mouse	3.16214437
11	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.14513437
12	MYC_19079543_ChIP-ChIP_MESCs_Mouse	3.02968936
13	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.02286219
14	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.95300684
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.81953722
16	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.74356510
17	AR_21909140_ChIP-Seq_LNCAP_Human	2.63323956
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.61696370
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.39136985
20	XRN2_22483619_ChIP-Seq_HELA_Human	2.36953839
21	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.29834632
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.24985870
23	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.22962572
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.21797927
25	TTF2_22483619_ChIP-Seq_HELA_Human	2.19126600
26	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.12736376
27	DCP1A_22483619_ChIP-Seq_HELA_Human	2.12383556
28	GABP_19822575_ChIP-Seq_HepG2_Human	2.10702786
29	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.08718743
30	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.08417475
31	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.00219449
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.93762581
33	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.93594264
34	VDR_23849224_ChIP-Seq_CD4+_Human	1.87486776
35	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.85718108
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.84995923
37	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.82705087
38	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.80870496
39	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.78757769
40	ELK1_19687146_ChIP-ChIP_HELA_Human	1.78542647
41	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.76962423
42	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.76851451
43	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.75341023
44	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.70968574
45	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.67858052
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.65395011
47	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.64088375
48	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.63973136
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.63105737
50	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.56334778
51	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.54646469
52	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.52584825
53	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.47799062
54	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.46207990
55	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.44399221
56	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.38464570
57	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.36202148
58	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.33685273
59	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.33181460
60	KDM5A_27292631_Chip-Seq_BREAST_Human	1.31901785
61	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.29161053
62	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.20126238
63	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.18795927
64	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.15673954
65	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.14231775
66	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.09417781
67	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.06849598
68	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.06700746
69	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.06510237
70	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.05906645
71	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.03523444
72	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.01281138
73	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.96982198
74	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.94230953
75	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.93574192
76	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.93384234
77	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.92707833
78	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.92564036
79	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.90713178
80	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.88878845
81	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.88171452
82	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.85648737
83	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.85407165
84	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.85313131
85	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.84826904
86	ZNF263_19887448_ChIP-Seq_K562_Human	0.84091331
87	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.81590080
88	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.79605015
89	TFEB_21752829_ChIP-Seq_HELA_Human	0.78697770
90	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.78183106
91	ELF5_23300383_ChIP-Seq_T47D_Human	0.77975590
92	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.77948154
93	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.76945809
94	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.76874942
95	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.75904190
96	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.73763914
97	CHD1_26751641_Chip-Seq_LNCaP_Human	0.73598807
98	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.73105134
99	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.72975986
100	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.71274947

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.47599581
2	MP0003693_abnormal_embryo_hatching	3.93444005
3	MP0010094_abnormal_chromosome_stability	3.92773306
4	MP0010030_abnormal_orbit_morphology	3.36454701
5	MP0008058_abnormal_DNA_repair	3.33824721
6	MP0004957_abnormal_blastocyst_morpholog	3.32178383
7	MP0008789_abnormal_olfactory_epithelium	2.99927194
8	MP0008057_abnormal_DNA_replication	2.94556337
9	MP0003111_abnormal_nucleus_morphology	2.81886734
10	MP0003077_abnormal_cell_cycle	2.79796630
11	MP0009697_abnormal_copulation	2.69011006
12	MP0008932_abnormal_embryonic_tissue	2.57814230
13	MP0009379_abnormal_foot_pigmentation	2.52316212
14	MP0002234_abnormal_pharynx_morphology	2.46424825
15	MP0008877_abnormal_DNA_methylation	2.37509640
16	MP0005394_taste/olfaction_phenotype	2.34013175
17	MP0005499_abnormal_olfactory_system	2.34013175
18	MP0003718_maternal_effect	2.25121154
19	MP0000049_abnormal_middle_ear	1.87768552
20	MP0002938_white_spotting	1.84314822
21	MP0003806_abnormal_nucleotide_metabolis	1.83234766
22	MP0005257_abnormal_intraocular_pressure	1.75817530
23	MP0001730_embryonic_growth_arrest	1.68349338
24	MP0003941_abnormal_skin_development	1.61286172
25	MP0000678_abnormal_parathyroid_gland	1.58748100
26	MP0008007_abnormal_cellular_replicative	1.41983319
27	MP0003315_abnormal_perineum_morphology	1.37010396
28	MP0002163_abnormal_gland_morphology	1.36527513
29	MP0005501_abnormal_skin_physiology	1.35821681
30	MP0005410_abnormal_fertilization	1.34439344
31	MP0001929_abnormal_gametogenesis	1.34227589
32	MP0000350_abnormal_cell_proliferation	1.34099093
33	MP0002210_abnormal_sex_determination	1.30132272
34	MP0001697_abnormal_embryo_size	1.29304837
35	MP0006035_abnormal_mitochondrial_morpho	1.28235135
36	MP0003937_abnormal_limbs/digits/tail_de	1.26227733
37	MP0002160_abnormal_reproductive_system	1.25729777
38	MP0009053_abnormal_anal_canal	1.25164173
39	MP0001293_anophthalmia	1.23793807
40	MP0001764_abnormal_homeostasis	1.22736953
41	MP0004233_abnormal_muscle_weight	1.18171385
42	MP0002249_abnormal_larynx_morphology	1.17330798
43	MP0002085_abnormal_embryonic_tissue	1.15867241
44	MP0001145_abnormal_male_reproductive	1.10900819
45	MP0006036_abnormal_mitochondrial_physio	1.08485845
46	MP0002080_prenatal_lethality	1.08217283
47	MP0005380_embryogenesis_phenotype	1.07709387
48	MP0001672_abnormal_embryogenesis/_devel	1.07709387
49	MP0002697_abnormal_eye_size	1.04604662
50	MP0003698_abnormal_male_reproductive	1.02163779
51	MP0000653_abnormal_sex_gland	1.01061944
52	MP0001346_abnormal_lacrimal_gland	1.00497414
53	MP0002796_impaired_skin_barrier	0.98872910
54	MP0003938_abnormal_ear_development	0.97122593
55	MP0002084_abnormal_developmental_patter	0.96788294
56	MP0000313_abnormal_cell_death	0.94480261
57	MP0000566_synostosis	0.94064734
58	MP0003119_abnormal_digestive_system	0.93879514
59	MP0005623_abnormal_meninges_morphology	0.93386561
60	MP0002092_abnormal_eye_morphology	0.93319441
61	MP0003186_abnormal_redox_activity	0.93180415
62	MP0001661_extended_life_span	0.91948308
63	MP0002233_abnormal_nose_morphology	0.91675241
64	MP0000537_abnormal_urethra_morphology	0.89745225
65	MP0005408_hypopigmentation	0.89036173
66	MP0002161_abnormal_fertility/fecundity	0.86271314
67	MP0001529_abnormal_vocalization	0.86144989
68	MP0000358_abnormal_cell_content/	0.85667379
69	MP0001286_abnormal_eye_development	0.85465586
70	MP0003942_abnormal_urinary_system	0.85262640
71	MP0003755_abnormal_palate_morphology	0.85035715
72	MP0003121_genomic_imprinting	0.84542370
73	MP0000762_abnormal_tongue_morphology	0.83988253
74	MP0000428_abnormal_craniofacial_morphol	0.83742014
75	MP0005379_endocrine/exocrine_gland_phen	0.82991653
76	MP0009250_abnormal_appendicular_skeleto	0.81439495
77	MP0002111_abnormal_tail_morphology	0.80943195
78	MP0000613_abnormal_salivary_gland	0.79875786
79	MP0004185_abnormal_adipocyte_glucose	0.79797585
80	MP0003984_embryonic_growth_retardation	0.78826318
81	MP0004197_abnormal_fetal_growth/weight/	0.78728138
82	MP0003567_abnormal_fetal_cardiomyocyte	0.78338318
83	MP0003786_premature_aging	0.77443493
84	MP0002088_abnormal_embryonic_growth/wei	0.76564987
85	MP0005389_reproductive_system_phenotype	0.76106916
86	MP0005646_abnormal_pituitary_gland	0.75843062
87	MP0005395_other_phenotype	0.74183623
88	MP0002177_abnormal_outer_ear	0.73649751
89	MP0001849_ear_inflammation	0.73453427
90	MP0010307_abnormal_tumor_latency	0.73049580
91	MP0001119_abnormal_female_reproductive	0.72605619
92	MP0000631_abnormal_neuroendocrine_gland	0.71711362
93	MP0003890_abnormal_embryonic-extraembry	0.71079565
94	MP0001340_abnormal_eyelid_morphology	0.71074870
95	MP0003123_paternal_imprinting	0.70439507
96	MP0003699_abnormal_female_reproductive	0.70405636
97	MP0000681_abnormal_thyroid_gland	0.68967771
98	MP0000490_abnormal_crypts_of	0.68012044
99	MP0001919_abnormal_reproductive_system	0.67197972
100	MP0002751_abnormal_autonomic_nervous	0.66043066

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromsome breakage (HP:0040012)	3.60909163
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.43996012
3	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.29485405
4	Ectopic kidney (HP:0000086)	3.29380662
5	Reticulocytopenia (HP:0001896)	3.29289173
6	Reduced antithrombin III activity (HP:0001976)	3.03155254
7	Acute necrotizing encephalopathy (HP:0006965)	2.95475690
8	Acute encephalopathy (HP:0006846)	2.89569768
9	Abnormal mitochondria in muscle tissue (HP:0008316)	2.89180451
10	Colon cancer (HP:0003003)	2.87512680
11	Microglossia (HP:0000171)	2.74552481
12	Macrocytic anemia (HP:0001972)	2.70062115
13	Abnormality of the ileum (HP:0001549)	2.64214107
14	Meckel diverticulum (HP:0002245)	2.60973137
15	Ependymoma (HP:0002888)	2.60945425
16	Abnormality of methionine metabolism (HP:0010901)	2.52863112
17	Abnormality of cells of the erythroid lineage (HP:0012130)	2.51951508
18	Birth length less than 3rd percentile (HP:0003561)	2.50587755
19	Type I transferrin isoform profile (HP:0003642)	2.50479208
20	Spinal cord compression (HP:0002176)	2.49988659
21	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.48040440
22	Rhabdomyosarcoma (HP:0002859)	2.47954219
23	Multiple enchondromatosis (HP:0005701)	2.47056026
24	Mitochondrial inheritance (HP:0001427)	2.46955235
25	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.41744162
26	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.41744162
27	Hyperglycinemia (HP:0002154)	2.41066765
28	Exertional dyspnea (HP:0002875)	2.36831113
29	Cerebral edema (HP:0002181)	2.36753229
30	Abnormality of chromosome stability (HP:0003220)	2.36390400
31	Abnormality of the preputium (HP:0100587)	2.34525497
32	Progressive muscle weakness (HP:0003323)	2.34417680
33	Increased CSF lactate (HP:0002490)	2.32321800
34	Abnormal number of erythroid precursors (HP:0012131)	2.32108192
35	Medulloblastoma (HP:0002885)	2.30941086
36	Renal Fanconi syndrome (HP:0001994)	2.29347725
37	Progressive macrocephaly (HP:0004481)	2.25605618
38	Abnormal ciliary motility (HP:0012262)	2.22555674
39	Abnormality of cochlea (HP:0000375)	2.22253305
40	Microvesicular hepatic steatosis (HP:0001414)	2.19907323
41	Triphalangeal thumb (HP:0001199)	2.19351326
42	Abnormal respiratory motile cilium physiology (HP:0012261)	2.18362588
43	Abnormal glycosylation (HP:0012345)	2.18061433
44	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.18061433
45	Abnormal protein N-linked glycosylation (HP:0012347)	2.18061433
46	Abnormal protein glycosylation (HP:0012346)	2.18061433
47	Abnormal respiratory motile cilium morphology (HP:0005938)	2.16919799
48	Abnormal respiratory epithelium morphology (HP:0012253)	2.16919799
49	Male infertility (HP:0003251)	2.13214250
50	Hepatocellular necrosis (HP:0001404)	2.09548857
51	Glioma (HP:0009733)	2.07518544
52	Exercise intolerance (HP:0003546)	2.07353398
53	Hepatic necrosis (HP:0002605)	2.05328265
54	Increased serum lactate (HP:0002151)	2.05273686
55	Sensory axonal neuropathy (HP:0003390)	2.02387223
56	Nephroblastoma (Wilms tumor) (HP:0002667)	2.02222042
57	Megaloblastic anemia (HP:0001889)	1.99790629
58	Postnatal microcephaly (HP:0005484)	1.99638156
59	Increased hepatocellular lipid droplets (HP:0006565)	1.98614176
60	Premature ovarian failure (HP:0008209)	1.96778711
61	Carpal bone hypoplasia (HP:0001498)	1.94747307
62	Embryonal renal neoplasm (HP:0011794)	1.93122856
63	Absent thumb (HP:0009777)	1.91771880
64	Duodenal stenosis (HP:0100867)	1.91670569
65	Small intestinal stenosis (HP:0012848)	1.91670569
66	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.91290149
67	Abnormality of the duodenum (HP:0002246)	1.87815191
68	Secondary amenorrhea (HP:0000869)	1.86283996
69	Abnormality of the carotid arteries (HP:0005344)	1.85656744
70	Abnormality of serum amino acid levels (HP:0003112)	1.84642279
71	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.84433859
72	Pallor (HP:0000980)	1.84032397
73	Generalized amyotrophy (HP:0003700)	1.82639225
74	Lactic acidosis (HP:0003128)	1.81828744
75	Abnormality of the astrocytes (HP:0100707)	1.79264673
76	Astrocytoma (HP:0009592)	1.79264673
77	Pendular nystagmus (HP:0012043)	1.78338900
78	Delayed myelination (HP:0012448)	1.78126504
79	Abnormality of the umbilical cord (HP:0010881)	1.77075046
80	Abnormality of glycine metabolism (HP:0010895)	1.77022898
81	Abnormality of serine family amino acid metabolism (HP:0010894)	1.77022898
82	Generalized aminoaciduria (HP:0002909)	1.76951540
83	B lymphocytopenia (HP:0010976)	1.76344735
84	Morphological abnormality of the inner ear (HP:0011390)	1.76211206
85	Absent/shortened dynein arms (HP:0200106)	1.76139039
86	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.76139039
87	Breast hypoplasia (HP:0003187)	1.75032750
88	Methylmalonic acidemia (HP:0002912)	1.74830885
89	Abnormality of the fetal cardiovascular system (HP:0010948)	1.74747422
90	Abnormal umbilical cord blood vessels (HP:0011403)	1.74747422
91	Single umbilical artery (HP:0001195)	1.74747422
92	Congenital malformation of the right heart (HP:0011723)	1.74719762
93	Double outlet right ventricle (HP:0001719)	1.74719762
94	Slender build (HP:0001533)	1.74704600
95	Biliary tract neoplasm (HP:0100574)	1.74668319
96	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.74357235
97	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.73093370
98	Hypoplasia of the fovea (HP:0007750)	1.73093370
99	Absent radius (HP:0003974)	1.71973032
100	Volvulus (HP:0002580)	1.71659135

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	5.27375711
2	BUB1	3.97339723
3	CDC7	3.58635762
4	TTK	3.00014696
5	PLK4	2.68142017
6	SMG1	2.39764622
7	SRPK1	2.39191586
8	TAF1	2.37156716
9	ZAK	2.29845839
10	PBK	2.17514541
11	NME2	2.14734361
12	CDK8	2.08001214
13	WEE1	2.03922165
14	CDK7	1.86774101
15	EIF2AK3	1.85244092
16	MST4	1.83180703
17	VRK1	1.77469572
18	PLK1	1.72093419
19	PLK3	1.68304384
20	BRSK1	1.65430177
21	CHEK2	1.63495068
22	TNIK	1.58894628
23	NUAK1	1.58423096
24	EIF2AK1	1.58371882
25	RPS6KB2	1.52952283
26	ATR	1.52075253
27	MAP3K12	1.50753518
28	BRSK2	1.45388864
29	NEK1	1.44786685
30	BCKDK	1.40249292
31	AURKA	1.35836960
32	CSNK1G3	1.27241424
33	TRIM28	1.24746363
34	EPHA2	1.21232539
35	SCYL2	1.21209105
36	AURKB	1.18017127
37	TSSK6	1.16137097
38	CSNK1G1	1.14515104
39	TESK2	1.12019923
40	NME1	1.11565420
41	MST1R	1.09999546
42	CHEK1	1.09699590
43	MET	1.09373420
44	STK16	1.07877634
45	CSNK1A1L	1.07776028
46	DYRK2	0.97707660
47	RPS6KA4	0.97615247
48	PASK	0.96721560
49	PAK4	0.95054150
50	BRAF	0.94851116
51	CDK19	0.93329333
52	CSNK1G2	0.92297122
53	MAP3K8	0.83583719
54	PRKD3	0.82045737
55	DAPK1	0.81892933
56	ARAF	0.81291013
57	CDK9	0.79845106
58	IRAK2	0.78049486
59	MUSK	0.75038779
60	ERBB3	0.73706885
61	MAP3K10	0.73636853
62	CSNK2A2	0.70757055
63	ATM	0.69364225
64	MAP3K9	0.68119378
65	EIF2AK2	0.66355024
66	CDK3	0.65541673
67	CDK2	0.63730136
68	EPHA4	0.62550133
69	BMPR1B	0.59465665
70	CDK1	0.56937144
71	CSNK2A1	0.55973312
72	STK4	0.55675691
73	PRKCI	0.54939761
74	PLK2	0.54196609
75	STK3	0.54101007
76	STK38L	0.54092097
77	NEK2	0.54068600
78	AKT2	0.53330412
79	CCNB1	0.52925880
80	MKNK1	0.52787334
81	ERBB4	0.52279460
82	TESK1	0.50298656
83	CSNK1E	0.49565768
84	ILK	0.45023348
85	BMX	0.44384712
86	CSNK1A1	0.42457055
87	CSNK1D	0.41829873
88	DYRK3	0.41685507
89	MYLK	0.38845396
90	NEK6	0.37686882
91	STK24	0.35967161
92	RPS6KA5	0.34582111
93	LRRK2	0.33309397
94	MELK	0.32739062
95	PAK1	0.32592874
96	MKNK2	0.30349778
97	FLT3	0.29902368
98	PRKDC	0.29541464
99	LATS1	0.28766783
100	CDK11A	0.27123377

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	4.92814012
2	Mismatch repair_Homo sapiens_hsa03430	4.34712299
3	Ribosome_Homo sapiens_hsa03010	3.27375222
4	Base excision repair_Homo sapiens_hsa03410	2.91168546
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.77666496
6	Proteasome_Homo sapiens_hsa03050	2.74646601
7	Homologous recombination_Homo sapiens_hsa03440	2.61513086
8	Nucleotide excision repair_Homo sapiens_hsa03420	2.56092449
9	Non-homologous end-joining_Homo sapiens_hsa03450	2.40178647
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.31711185
11	RNA transport_Homo sapiens_hsa03013	2.25670125
12	RNA polymerase_Homo sapiens_hsa03020	2.20286718
13	Spliceosome_Homo sapiens_hsa03040	2.11359163
14	Cell cycle_Homo sapiens_hsa04110	2.10490141
15	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.07835370
16	One carbon pool by folate_Homo sapiens_hsa00670	2.07522184
17	Pyrimidine metabolism_Homo sapiens_hsa00240	2.05583739
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.74386944
19	Sulfur relay system_Homo sapiens_hsa04122	1.71627188
20	Oxidative phosphorylation_Homo sapiens_hsa00190	1.71448372
21	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.68532689
22	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.58127316
23	Parkinsons disease_Homo sapiens_hsa05012	1.57454085
24	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.54370808
25	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.53433038
26	Huntingtons disease_Homo sapiens_hsa05016	1.51527553
27	Basal transcription factors_Homo sapiens_hsa03022	1.38139742
28	RNA degradation_Homo sapiens_hsa03018	1.37940275
29	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.37247793
30	Folate biosynthesis_Homo sapiens_hsa00790	1.37157265
31	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.35936724
32	Fatty acid elongation_Homo sapiens_hsa00062	1.34252866
33	Pyruvate metabolism_Homo sapiens_hsa00620	1.25578553
34	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.24781742
35	Glutathione metabolism_Homo sapiens_hsa00480	1.20509311
36	mRNA surveillance pathway_Homo sapiens_hsa03015	1.14809487
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.12930458
38	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.11322344
39	Carbon metabolism_Homo sapiens_hsa01200	1.11293963
40	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.09985246
41	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.05287782
42	Purine metabolism_Homo sapiens_hsa00230	1.04419632
43	Alzheimers disease_Homo sapiens_hsa05010	1.02600632
44	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.00549124
45	Protein export_Homo sapiens_hsa03060	0.97976259
46	Steroid biosynthesis_Homo sapiens_hsa00100	0.97892913
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.97439942
48	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.93547830
49	Pentose phosphate pathway_Homo sapiens_hsa00030	0.89791318
50	Propanoate metabolism_Homo sapiens_hsa00640	0.81612259
51	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.80977932
52	Oocyte meiosis_Homo sapiens_hsa04114	0.80115326
53	Arginine and proline metabolism_Homo sapiens_hsa00330	0.79104938
54	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.74543835
55	Metabolic pathways_Homo sapiens_hsa01100	0.73179325
56	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.72426328
57	p53 signaling pathway_Homo sapiens_hsa04115	0.71656076
58	Phenylalanine metabolism_Homo sapiens_hsa00360	0.70751674
59	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.70289471
60	Peroxisome_Homo sapiens_hsa04146	0.69553185
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.69029197
62	Basal cell carcinoma_Homo sapiens_hsa05217	0.69012088
63	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.68494141
64	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.68293006
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67415804
66	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.64847060
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59868871
68	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.56475211
69	Selenocompound metabolism_Homo sapiens_hsa00450	0.54209253
70	Retinol metabolism_Homo sapiens_hsa00830	0.53256362
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.51170279
72	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.50075682
73	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.47117588
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.46148286
75	Tyrosine metabolism_Homo sapiens_hsa00350	0.46032382
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.42446060
77	Butanoate metabolism_Homo sapiens_hsa00650	0.40386449
78	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.40047294
79	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.36712242
80	Arginine biosynthesis_Homo sapiens_hsa00220	0.35990740
81	Thyroid cancer_Homo sapiens_hsa05216	0.35159000
82	Wnt signaling pathway_Homo sapiens_hsa04310	0.31386546
83	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.31263028
84	Sulfur metabolism_Homo sapiens_hsa00920	0.28775638
85	Cardiac muscle contraction_Homo sapiens_hsa04260	0.28061858
86	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.27365400
87	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.27256088
88	Galactose metabolism_Homo sapiens_hsa00052	0.25311749
89	Fatty acid metabolism_Homo sapiens_hsa01212	0.25056063
90	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.22869436
91	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.22849307
92	Hippo signaling pathway_Homo sapiens_hsa04390	0.22416838
93	Lysine degradation_Homo sapiens_hsa00310	0.22259957
94	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.21439824
95	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.18035828
96	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.16326754
97	Fat digestion and absorption_Homo sapiens_hsa04975	0.15926520
98	Fatty acid degradation_Homo sapiens_hsa00071	0.14985516
99	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.12742389
100	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.10971421

FAM86JP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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