FAM86KP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine deoxyribonucleotide catabolic process (GO:0009223)9.17957313
2regulation of mitochondrial translation (GO:0070129)8.54707914
3water-soluble vitamin biosynthetic process (GO:0042364)8.41324377
4negative regulation of membrane potential (GO:0045837)7.98171242
5pyrimidine nucleotide catabolic process (GO:0006244)7.88173185
6base-excision repair, AP site formation (GO:0006285)7.42049944
7protein K48-linked deubiquitination (GO:0071108)6.94681036
8protein complex biogenesis (GO:0070271)6.66057213
9histone deubiquitination (GO:0016578)6.52832343
10positive regulation of endothelial cell differentiation (GO:0045603)6.46586171
11positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc6.24515647
12mitochondrial respiratory chain complex assembly (GO:0033108)6.00946671
13pyrimidine deoxyribonucleotide metabolic process (GO:0009219)5.57031552
14pseudouridine synthesis (GO:0001522)5.52278230
15negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)5.44284750
16cytochrome complex assembly (GO:0017004)5.27289545
17misfolded or incompletely synthesized protein catabolic process (GO:0006515)5.19296856
18aggressive behavior (GO:0002118)5.17228645
19negative regulation of DNA-templated transcription, elongation (GO:0032785)4.98298741
20deoxyribonucleotide catabolic process (GO:0009264)4.94276015
21cobalamin metabolic process (GO:0009235)4.93293140
22protein import into peroxisome matrix (GO:0016558)4.67975159
23deoxyribose phosphate catabolic process (GO:0046386)4.67313418
24deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.57643063
25regulation of endothelial cell differentiation (GO:0045601)4.55882082
26maternal behavior (GO:0042711)4.50679526
27response to gravity (GO:0009629)4.49065282
28mitochondrial respiratory chain complex I assembly (GO:0032981)4.20549693
29NADH dehydrogenase complex assembly (GO:0010257)4.20549693
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.20549693
31embryonic skeletal joint morphogenesis (GO:0060272)4.13521106
32positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.12843325
33vitamin biosynthetic process (GO:0009110)4.11751490
34parental behavior (GO:0060746)3.93373760
35glyoxylate metabolic process (GO:0046487)3.89893713
36regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.74733731
37regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.74733731
38L-phenylalanine catabolic process (GO:0006559)3.70976163
39erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.70976163
40regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.70237754
41positive regulation of fatty acid transport (GO:2000193)3.65457111
42L-phenylalanine metabolic process (GO:0006558)3.64019605
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.64019605
44energy homeostasis (GO:0097009)3.56100442
45middle ear morphogenesis (GO:0042474)3.53519152
46angiogenesis involved in wound healing (GO:0060055)3.47644447
47long term synaptic depression (GO:0060292)3.46340047
48regulation of fatty acid beta-oxidation (GO:0031998)3.41950815
49protein neddylation (GO:0045116)3.40118414
50proteasome assembly (GO:0043248)3.34681791
51kidney mesenchyme development (GO:0072074)3.30951592
52chaperone-mediated protein transport (GO:0072321)3.29922945
53peptidyl-histidine modification (GO:0018202)3.28054121
54behavioral response to nicotine (GO:0035095)3.27578781
55protein localization to peroxisome (GO:0072662)3.26567312
56protein targeting to peroxisome (GO:0006625)3.26567312
57establishment of protein localization to peroxisome (GO:0072663)3.26567312
582-deoxyribonucleotide metabolic process (GO:0009394)3.26263753
59adaptation of signaling pathway (GO:0023058)3.26027640
603-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.24592924
61purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.24592924
62serotonin metabolic process (GO:0042428)3.23992346
63tetrapyrrole biosynthetic process (GO:0033014)3.23194989
64dentate gyrus development (GO:0021542)3.20350033
65retinal rod cell development (GO:0046548)3.11679597
66cellular response to BMP stimulus (GO:0071773)3.09209538
67response to BMP (GO:0071772)3.09209538
68substrate-independent telencephalic tangential migration (GO:0021826)3.03561906
69substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.03561906
70deoxyribose phosphate metabolic process (GO:0019692)3.02176154
71limb development (GO:0060173)3.00957283
72appendage development (GO:0048736)3.00957283
73regulation of cardioblast proliferation (GO:0003264)3.00068173
74regulation of secondary heart field cardioblast proliferation (GO:0003266)3.00068173
75positive regulation of erythrocyte differentiation (GO:0045648)2.99313805
76phosphatidylethanolamine biosynthetic process (GO:0006646)2.97699937
77tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.95842189
78RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.95842189
79negative regulation of appetite (GO:0032099)2.93077527
80negative regulation of response to food (GO:0032096)2.93077527
81positive regulation of TOR signaling (GO:0032008)2.90499196
82negative regulation of phagocytosis (GO:0050765)2.89310634
83negative regulation of cell aging (GO:0090344)2.88584887
84response to misfolded protein (GO:0051788)2.88062907
85deoxyribonucleotide metabolic process (GO:0009262)2.86643578
86forebrain morphogenesis (GO:0048853)2.86607944
87peroxisomal transport (GO:0043574)2.83776772
88activin receptor signaling pathway (GO:0032924)2.82878743
89behavioral response to cocaine (GO:0048148)2.78965704
90primary amino compound metabolic process (GO:1901160)2.78865416
91synaptic transmission, dopaminergic (GO:0001963)2.77559348
92regulation of neurotransmitter uptake (GO:0051580)2.76696745
93adenosine metabolic process (GO:0046085)2.76123117
94DNA catabolic process, endonucleolytic (GO:0000737)2.74120300
95actin filament polymerization (GO:0030041)2.73818688
96intracellular protein transmembrane import (GO:0044743)2.73245876
97metanephric mesenchyme development (GO:0072075)2.73149108
98aromatic amino acid family metabolic process (GO:0009072)2.69720956
99replication fork processing (GO:0031297)2.66940646
100monoubiquitinated protein deubiquitination (GO:0035520)14.0796829

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.55968010
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.85132187
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.25996364
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.66796130
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.46186633
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.30744716
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.16717674
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.09967746
9CEBPB_24764292_ChIP-Seq_MC3T3_Mouse3.08040747
10STAT6_21828071_ChIP-Seq_BEAS2B_Human3.02133195
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.92624642
12SRF_21415370_ChIP-Seq_HL-1_Mouse2.58330827
13GABP_19822575_ChIP-Seq_HepG2_Human2.48715889
14SRY_22984422_ChIP-ChIP_TESTIS_Rat2.42674961
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.34872740
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.29872479
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.23743576
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15185579
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14615787
20ELF1_20517297_ChIP-Seq_JURKAT_Human2.07804719
21CIITA_25753668_ChIP-Seq_RAJI_Human2.07326876
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04239352
23CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.94489603
24ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.93180204
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.85721679
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.82786658
27BCL6_27268052_Chip-Seq_Bcells_Human1.78228382
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78173554
29TET1_21451524_ChIP-Seq_MESCs_Mouse1.76813600
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71830716
31CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.68516323
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66830751
33P68_20966046_ChIP-Seq_HELA_Human1.62642161
34SOX2_21211035_ChIP-Seq_LN229_Human1.58228170
35CTCF_18555785_ChIP-Seq_MESCs_Mouse1.55917752
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55651497
37VDR_23849224_ChIP-Seq_CD4+_Human1.55275783
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.54862451
39EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.50473650
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50060475
41SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.46688446
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.43687228
43FOXP3_21729870_ChIP-Seq_TREG_Human1.42458097
44PHF8_20622854_ChIP-Seq_HELA_Human1.41167490
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39489651
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.37304777
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.36091364
48DCP1A_22483619_ChIP-Seq_HELA_Human1.31901774
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31624309
50LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.31493754
51SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.30891917
52SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30772401
53E2F1_20622854_ChIP-Seq_HELA_Human1.30483185
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26952565
55RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.26306279
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23307506
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21921207
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21376911
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.20501942
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19804792
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.19720605
62CTCF_20526341_ChIP-Seq_ESCs_Human1.19577841
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18420795
64TP53_22127205_ChIP-Seq_IMR90_Human1.17598109
65VDR_21846776_ChIP-Seq_THP-1_Human1.17363371
66CTCF_21964334_Chip-Seq_Bcells_Human1.15993049
67NANOG_20526341_ChIP-Seq_ESCs_Human1.15793241
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15316307
69TBX5_21415370_ChIP-Seq_HL-1_Mouse1.15202302
70RAC3_21632823_ChIP-Seq_H3396_Human1.15001422
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13744020
72YY1_22570637_ChIP-Seq_MALME-3M_Human1.13275782
73ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10695156
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10268145
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09306364
76SPI1_20517297_ChIP-Seq_HL60_Human1.09025401
77FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07271354
78FOXP1_21924763_ChIP-Seq_HESCs_Human1.07189003
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06462532
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.05581803
81BCOR_27268052_Chip-Seq_Bcells_Human1.04672972
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04145490
83ERA_21632823_ChIP-Seq_H3396_Human1.01899599
84SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01367893
85MYC_19829295_ChIP-Seq_ESCs_Human0.99721368
86CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99488450
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98354428
88CTCF_26484167_Chip-Seq_Bcells_Mouse0.96618120
89TTF2_22483619_ChIP-Seq_HELA_Human0.96533531
90NCOR_22424771_ChIP-Seq_293T_Human0.96427579
91TRIM28_21343339_ChIP-Seq_HEK293_Human0.95931377
92IRF1_19129219_ChIP-ChIP_H3396_Human0.94899038
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94847134
94RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94481370
95CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.92462295
96PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91544018
97RARA_24833708_ChIP-Seq_LIVER_Mouse0.91254467
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91200123
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90556753
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89862792

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue9.30580593
2MP0002837_dystrophic_cardiac_calcinosis6.41169111
3MP0003122_maternal_imprinting4.93884031
4MP0000537_abnormal_urethra_morphology4.36246589
5MP0002736_abnormal_nociception_after3.71708492
6MP0001853_heart_inflammation3.51468914
7MP0003011_delayed_dark_adaptation3.14121737
8MP0010030_abnormal_orbit_morphology2.76193788
9MP0003121_genomic_imprinting2.68216930
10MP0004742_abnormal_vestibular_system2.63337540
11MP0001968_abnormal_touch/_nociception2.56144332
12MP0003890_abnormal_embryonic-extraembry2.54987561
13MP0001905_abnormal_dopamine_level2.45489856
14MP0004185_abnormal_adipocyte_glucose2.38906942
15MP0008775_abnormal_heart_ventricle2.30532577
16MP0003123_paternal_imprinting2.03792239
17MP0005670_abnormal_white_adipose2.01728301
18MP0004133_heterotaxia1.97268291
19MP0004130_abnormal_muscle_cell1.93581906
20MP0008875_abnormal_xenobiotic_pharmacok1.82769217
21MP0001346_abnormal_lacrimal_gland1.81375241
22MP0002938_white_spotting1.76040236
23MP0008789_abnormal_olfactory_epithelium1.70947256
24MP0001529_abnormal_vocalization1.67252674
25MP0002735_abnormal_chemical_nociception1.66411108
26MP0001270_distended_abdomen1.53536156
27MP0009046_muscle_twitch1.52356935
28MP0000343_altered_response_to1.48781590
29MP0005408_hypopigmentation1.42061666
30MP0001984_abnormal_olfaction1.35599282
31MP0008058_abnormal_DNA_repair1.33708142
32MP0000538_abnormal_urinary_bladder1.31610180
33MP0000049_abnormal_middle_ear1.24806775
34MP0005058_abnormal_lysosome_morphology1.21603476
35MP0002234_abnormal_pharynx_morphology1.21298038
36MP0000516_abnormal_urinary_system1.18370955
37MP0005367_renal/urinary_system_phenotyp1.18370955
38MP0009764_decreased_sensitivity_to1.16320974
39MP0001486_abnormal_startle_reflex1.14066821
40MP0005332_abnormal_amino_acid1.08560524
41MP0005503_abnormal_tendon_morphology1.05912026
42MP0000681_abnormal_thyroid_gland1.04024499
43MP0005386_behavior/neurological_phenoty0.99236317
44MP0004924_abnormal_behavior0.99236317
45MP0009250_abnormal_appendicular_skeleto0.94276117
46MP0010234_abnormal_vibrissa_follicle0.93822346
47MP0002932_abnormal_joint_morphology0.91930627
48MP0002928_abnormal_bile_duct0.91524850
49MP0001963_abnormal_hearing_physiology0.90957218
50MP0005666_abnormal_adipose_tissue0.90382021
51MP0001666_abnormal_nutrient_absorption0.86881866
52MP0005084_abnormal_gallbladder_morpholo0.85539522
53MP0005174_abnormal_tail_pigmentation0.85278019
54MP0009384_cardiac_valve_regurgitation0.82591148
55MP0001756_abnormal_urination0.81655450
56MP0002557_abnormal_social/conspecific_i0.81446750
57MP0002277_abnormal_respiratory_mucosa0.80208845
58MP0001727_abnormal_embryo_implantation0.77267526
59MP0000026_abnormal_inner_ear0.76162333
60MP0005397_hematopoietic_system_phenotyp0.70961214
61MP0001545_abnormal_hematopoietic_system0.70961214
62MP0003633_abnormal_nervous_system0.70520488
63MP0003937_abnormal_limbs/digits/tail_de0.64634733
64MP0000230_abnormal_systemic_arterial0.64536399
65MP0003942_abnormal_urinary_system0.64159789
66MP0002653_abnormal_ependyma_morphology0.64153854
67MP0003567_abnormal_fetal_cardiomyocyte0.63350777
68MP0009278_abnormal_bone_marrow0.61061917
69MP0002067_abnormal_sensory_capabilities0.60045544
70MP0001485_abnormal_pinna_reflex0.59247602
71MP0003638_abnormal_response/metabolism_0.58515657
72MP0009765_abnormal_xenobiotic_induced0.57107976
73MP0003786_premature_aging0.56109543
74MP0001661_extended_life_span0.53128402
75MP0002572_abnormal_emotion/affect_behav0.52266069
76MP0001849_ear_inflammation0.50268697
77MP0002282_abnormal_trachea_morphology0.48989554
78MP0002876_abnormal_thyroid_physiology0.48780373
79MP0005584_abnormal_enzyme/coenzyme_acti0.48700796
80MP0005375_adipose_tissue_phenotype0.48350776
81MP0005334_abnormal_fat_pad0.47934245
82MP0005508_abnormal_skeleton_morphology0.47809312
83MP0005075_abnormal_melanosome_morpholog0.47333416
84MP0001299_abnormal_eye_distance/0.46844956
85MP0006292_abnormal_olfactory_placode0.46613253
86MP0001340_abnormal_eyelid_morphology0.46176892
87MP0000566_synostosis0.44483482
88MP0001188_hyperpigmentation0.44428652
89MP0005645_abnormal_hypothalamus_physiol0.44081285
90MP0010329_abnormal_lipoprotein_level0.42607427
91MP0000015_abnormal_ear_pigmentation0.40958609
92MP0004085_abnormal_heartbeat0.40899247
93MP0003936_abnormal_reproductive_system0.40877290
94MP0001970_abnormal_pain_threshold0.40760629
95MP0006072_abnormal_retinal_apoptosis0.40020667
96MP0003755_abnormal_palate_morphology0.38589556
97MP0005410_abnormal_fertilization0.38411850
98MP0002106_abnormal_muscle_physiology0.38308206
99MP0002272_abnormal_nervous_system0.37069234
100MP0003631_nervous_system_phenotype0.36364416

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinemia (HP:0002154)7.63661749
2Meningioma (HP:0002858)7.52540207
3Methylmalonic aciduria (HP:0012120)6.89120798
4Methylmalonic acidemia (HP:0002912)6.22934757
5Dicarboxylic aciduria (HP:0003215)5.01073573
6Abnormality of dicarboxylic acid metabolism (HP:0010995)5.01073573
7Neoplasm of the lung (HP:0100526)4.37202312
8Abnormality of serine family amino acid metabolism (HP:0010894)4.25252865
9Abnormality of glycine metabolism (HP:0010895)4.25252865
10Melanoma (HP:0002861)4.04947766
11Neoplasm of the respiratory system (HP:0100606)3.92975608
12Lymphangioma (HP:0100764)3.76376665
13Ketosis (HP:0001946)3.75227601
14Abnormality of the vitamin B12 metabolism (HP:0004341)3.63498562
15Benign neoplasm of the central nervous system (HP:0100835)3.56290583
16Microvesicular hepatic steatosis (HP:0001414)3.52125281
17Abnormality of vitamin B metabolism (HP:0004340)3.32978803
18Type I transferrin isoform profile (HP:0003642)3.10340572
19Respiratory distress (HP:0002098)2.98006675
20Hyperthyroidism (HP:0000836)2.77248962
21Hyperammonemia (HP:0001987)2.75742455
22Subacute progressive viral hepatitis (HP:0006572)2.63936960
23Seborrheic dermatitis (HP:0001051)2.59003649
24Progressive macrocephaly (HP:0004481)2.57275141
25Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.56528861
26Abnormal protein N-linked glycosylation (HP:0012347)2.56528861
27Abnormal protein glycosylation (HP:0012346)2.56528861
28Abnormal glycosylation (HP:0012345)2.56528861
29Abnormality of aromatic amino acid family metabolism (HP:0004338)2.50193129
30Asymmetric septal hypertrophy (HP:0001670)2.45524094
31Pancytopenia (HP:0001876)2.39664489
32Hepatocellular necrosis (HP:0001404)2.39003473
33Buphthalmos (HP:0000557)2.38959502
34Joint stiffness (HP:0001387)2.37885053
35Mitochondrial inheritance (HP:0001427)2.36349050
36Neoplasm of the adrenal gland (HP:0100631)2.32929227
37Abnormal mitochondria in muscle tissue (HP:0008316)2.31551234
38Abnormal number of erythroid precursors (HP:0012131)2.24571458
39Hepatic necrosis (HP:0002605)2.23329724
40Coronal craniosynostosis (HP:0004440)2.22883198
41Multiple enchondromatosis (HP:0005701)2.22479094
42Acute necrotizing encephalopathy (HP:0006965)2.21352798
43Abnormality of the phalanges of the 2nd finger (HP:0009541)2.21031072
44Abnormality of serum amino acid levels (HP:0003112)2.20414383
45Abnormality of vitamin metabolism (HP:0100508)2.20240314
46Neonatal onset (HP:0003623)2.19731432
47Cerebral edema (HP:0002181)2.15205868
48Partial duplication of the phalanx of hand (HP:0009999)2.14611275
49Amblyopia (HP:0000646)2.14124888
50Acute encephalopathy (HP:0006846)2.11347183
51Short femoral neck (HP:0100864)2.10976193
52Exostoses (HP:0100777)2.09129173
53Small epiphyses (HP:0010585)2.08554722
54Mucopolysacchariduria (HP:0008155)2.04480067
55Urinary glycosaminoglycan excretion (HP:0003541)2.04480067
56Cutaneous melanoma (HP:0012056)16.3683645
57Congenital glaucoma (HP:0001087)1.99124275
58Corneal erosion (HP:0200020)1.98653683
59Abnormality of polysaccharide metabolism (HP:0011012)1.97861038
60Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97861038
61Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97861038
62Dysostosis multiplex (HP:0000943)1.95708013
63Spastic paraparesis (HP:0002313)1.94433243
64Congenital, generalized hypertrichosis (HP:0004540)1.94132550
65Broad distal phalanx of finger (HP:0009836)1.93037011
66Ovoid vertebral bodies (HP:0003300)1.91175050
67Ureteral duplication (HP:0000073)1.89973138
68Visceral angiomatosis (HP:0100761)1.88056137
69Lower limb asymmetry (HP:0100559)1.87687568
70Neoplasm of head and neck (HP:0012288)1.86426371
71Esophageal neoplasm (HP:0100751)1.86426371
72Torticollis (HP:0000473)1.86053687
73Ketoacidosis (HP:0001993)1.84982019
74Abnormality of cells of the erythroid lineage (HP:0012130)1.84299613
75Abnormality of subcutaneous fat tissue (HP:0001001)1.83299476
76Ulnar deviation of the wrist (HP:0003049)1.83288297
77Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.83010019
78Anxiety (HP:0000739)1.82014327
79Lethargy (HP:0001254)1.81651645
80Pigmentary retinal degeneration (HP:0001146)1.81392854
81Abnormality of the middle phalanges of the toes (HP:0010183)1.80779282
82Asymmetry of the thorax (HP:0001555)1.79335432
83Concave nail (HP:0001598)1.79198058
84Increased CSF lactate (HP:0002490)1.78764565
85Abnormality of the parathyroid morphology (HP:0011766)1.76289908
86Increased intramyocellular lipid droplets (HP:0012240)1.76088749
87Aplasia involving bones of the upper limbs (HP:0009823)1.73254636
88Aplasia of the phalanges of the hand (HP:0009802)1.73254636
89Aplasia involving bones of the extremities (HP:0009825)1.73254636
90Viral hepatitis (HP:0006562)1.72013787
91Abdominal distention (HP:0003270)1.71324176
92Reduced antithrombin III activity (HP:0001976)1.70227073
93Progressive neurologic deterioration (HP:0002344)1.68860206
94Bone cyst (HP:0012062)1.68841102
95Neoplasm of the adrenal cortex (HP:0100641)1.67465645
96Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.66472468
97Decreased activity of mitochondrial respiratory chain (HP:0008972)1.66472468
98Renal Fanconi syndrome (HP:0001994)1.65245576
99Irregular vertebral endplates (HP:0003301)1.64754196
100Short tibia (HP:0005736)1.64692788

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.35262749
2MAP3K136.15184086
3FGFR25.80848119
4BCKDK5.16527898
5TAOK33.42441296
6VRK22.91401027
7MAP3K141.90104003
8EPHB21.89565594
9PRKD21.76558821
10IKBKB1.71276427
11MAP4K21.66175851
12NUAK11.62767718
13PIM21.60031633
14ZAK1.56682279
15NME21.47439457
16NTRK11.43255229
17CCNB11.35217186
18STK161.33453608
19MAP3K71.31631332
20CSNK1G31.26696686
21CDK81.25439760
22KDR1.25318103
23TAF11.24811351
24STK381.20391537
25PTK2B1.17450116
26MAP3K111.12028009
27ICK1.11059430
28TESK21.09327406
29CSNK1A1L1.08747904
30LRRK21.03543433
31MAP4K11.02529712
32PBK1.00707156
33MYLK1.00543689
34CSNK1G20.91570388
35GRK60.89503546
36PRKD30.86972502
37PRKCQ0.86607706
38PLK10.84986784
39TBK10.84799918
40CSNK1G10.84177594
41FGFR30.80009633
42FLT30.79625987
43DYRK30.77560501
44MATK0.77377805
45VRK10.77281771
46JAK10.75663208
47INSRR0.74888899
48SMG10.72009715
49ABL20.70829512
50NTRK20.70654295
51PKN20.69910282
52DAPK10.69422103
53MAPKAPK30.66130614
54TXK0.64917480
55NEK20.64001888
56TLK10.60915317
57ATR0.57238259
58MAPK40.52904541
59ILK0.52155158
60MAP2K70.47017450
61ADRBK10.46987544
62MAPKAPK50.46878133
63GRK50.44222950
64TESK10.44040372
65DYRK20.43960838
66TIE10.43376495
67KIT0.43346530
68CHUK0.43241998
69RPS6KA40.42627333
70SGK10.42577529
71ADRBK20.42487786
72PLK30.41519434
73JAK30.39840939
74RPS6KA50.39444967
75TGFBR10.39156937
76AURKA0.38789760
77BMPR20.38425738
78ROCK10.38221170
79NEK90.37947814
80BUB10.35641205
81CSNK1A10.33359964
82LIMK10.30828999
83PIM10.30118335
84DAPK30.29453861
85PRKAA20.29228174
86AURKB0.28830014
87MAPK110.28519543
88PRKCE0.26595831
89STK100.26522123
90GRK10.26401782
91CSNK2A20.25452729
92PINK10.24992052
93CDK90.24145955
94ERBB20.24040104
95ERN10.23393631
96MAPK130.22232936
97PAK60.22091454
98PKN10.21284772
99PRKCZ0.20655465
100AKT20.20445554

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.46551183
2Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005345.18673337
3Base excision repair_Homo sapiens_hsa034103.18123482
4Sulfur relay system_Homo sapiens_hsa041222.68582832
5Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.51599970
6Oxidative phosphorylation_Homo sapiens_hsa001902.31678093
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.30884059
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.18641590
9Peroxisome_Homo sapiens_hsa041462.16988463
10Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.09693357
11RNA polymerase_Homo sapiens_hsa030202.06962335
12Fatty acid elongation_Homo sapiens_hsa000622.06724417
13Proteasome_Homo sapiens_hsa030502.03600632
14Parkinsons disease_Homo sapiens_hsa050121.97924157
15Folate biosynthesis_Homo sapiens_hsa007901.81727236
16DNA replication_Homo sapiens_hsa030301.81468519
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75642282
18Fanconi anemia pathway_Homo sapiens_hsa034601.70527593
19Pyrimidine metabolism_Homo sapiens_hsa002401.66933147
20Glutathione metabolism_Homo sapiens_hsa004801.59661984
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58858951
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54043624
23Ribosome_Homo sapiens_hsa030101.52759800
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52579243
25Tryptophan metabolism_Homo sapiens_hsa003801.47267676
26Huntingtons disease_Homo sapiens_hsa050161.26984888
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23450509
28Propanoate metabolism_Homo sapiens_hsa006401.21023089
29Fatty acid biosynthesis_Homo sapiens_hsa000611.18686059
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16604875
31Nucleotide excision repair_Homo sapiens_hsa034201.12639834
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12016916
33Alzheimers disease_Homo sapiens_hsa050101.08654759
34Other glycan degradation_Homo sapiens_hsa005111.06690052
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04698491
36Butanoate metabolism_Homo sapiens_hsa006501.03405880
37Fatty acid degradation_Homo sapiens_hsa000711.03361915
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99118663
39Vitamin digestion and absorption_Homo sapiens_hsa049770.97101412
40Glycerolipid metabolism_Homo sapiens_hsa005610.96286938
41Spliceosome_Homo sapiens_hsa030400.95903797
42Adipocytokine signaling pathway_Homo sapiens_hsa049200.94869953
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94191259
44Collecting duct acid secretion_Homo sapiens_hsa049660.92639969
45Fatty acid metabolism_Homo sapiens_hsa012120.92627558
46Phenylalanine metabolism_Homo sapiens_hsa003600.92611535
47Type II diabetes mellitus_Homo sapiens_hsa049300.91767773
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87288358
49Renin-angiotensin system_Homo sapiens_hsa046140.84331097
50Tyrosine metabolism_Homo sapiens_hsa003500.80707125
51Purine metabolism_Homo sapiens_hsa002300.79443022
52Metabolic pathways_Homo sapiens_hsa011000.78797914
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78768643
54Homologous recombination_Homo sapiens_hsa034400.78518951
55Shigellosis_Homo sapiens_hsa051310.78070565
56Fat digestion and absorption_Homo sapiens_hsa049750.77933132
57N-Glycan biosynthesis_Homo sapiens_hsa005100.77169266
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76377908
59Retinol metabolism_Homo sapiens_hsa008300.76185295
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75761996
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.75657792
62Basal transcription factors_Homo sapiens_hsa030220.73557118
63p53 signaling pathway_Homo sapiens_hsa041150.72220909
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68962615
65TGF-beta signaling pathway_Homo sapiens_hsa043500.66281518
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65558828
67Melanoma_Homo sapiens_hsa052180.65297307
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64997920
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63148202
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62313105
71Chemical carcinogenesis_Homo sapiens_hsa052040.61790654
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.60901628
73Pentose phosphate pathway_Homo sapiens_hsa000300.58924552
74beta-Alanine metabolism_Homo sapiens_hsa004100.58468223
75RNA degradation_Homo sapiens_hsa030180.56330812
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54199605
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.52884015
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51753047
79Protein export_Homo sapiens_hsa030600.47687901
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44778944
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.43530742
82Endometrial cancer_Homo sapiens_hsa052130.41727129
83Carbon metabolism_Homo sapiens_hsa012000.41091160
84Nicotine addiction_Homo sapiens_hsa050330.40017878
85Regulation of autophagy_Homo sapiens_hsa041400.38905292
86PPAR signaling pathway_Homo sapiens_hsa033200.37683626
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36962558
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36467274
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35702978
90Linoleic acid metabolism_Homo sapiens_hsa005910.35191991
91Steroid biosynthesis_Homo sapiens_hsa001000.31429484
92Cardiac muscle contraction_Homo sapiens_hsa042600.31148640
93Galactose metabolism_Homo sapiens_hsa000520.30949824
94Primary immunodeficiency_Homo sapiens_hsa053400.30632371
95Arachidonic acid metabolism_Homo sapiens_hsa005900.27685199
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26167611
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25329025
98Alcoholism_Homo sapiens_hsa050340.25163933
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25160833
100Cocaine addiction_Homo sapiens_hsa050300.25044678

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