ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of B cell apoptotic process (GO:0002903)	5.30032853
2	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.07262146
3	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.07262146
4	DNA deamination (GO:0045006)	5.05053622
5	positive regulation of B cell differentiation (GO:0045579)	4.90848233
6	cilium or flagellum-dependent cell motility (GO:0001539)	4.87567202
7	energy homeostasis (GO:0097009)	4.55148407
8	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	4.43660259
9	purine nucleotide salvage (GO:0032261)	4.24655488
10	regulation of retinoic acid receptor signaling pathway (GO:0048385)	4.23790730
11	ADP metabolic process (GO:0046031)	4.17244586
12	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.16795648
13	C21-steroid hormone biosynthetic process (GO:0006700)	4.06946265
14	intraciliary transport (GO:0042073)	4.04600426
15	definitive hemopoiesis (GO:0060216)	4.01473977
16	platelet dense granule organization (GO:0060155)	3.99750636
17	protein retention in ER lumen (GO:0006621)	3.97204417
18	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	3.95037252
19	retinal rod cell development (GO:0046548)	3.90573224
20	preassembly of GPI anchor in ER membrane (GO:0016254)	3.89794167
21	mannosylation (GO:0097502)	3.80220037
22	spliceosomal tri-snRNP complex assembly (GO:0000244)	3.77612942
23	cytochrome complex assembly (GO:0017004)	3.76221422
24	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	3.74039452
25	C-terminal protein lipidation (GO:0006501)	3.71277119
26	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.71102810
27	L-ascorbic acid metabolic process (GO:0019852)	3.65135872
28	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.63307470
29	mitochondrial calcium ion transport (GO:0006851)	3.61664589
30	iron-sulfur cluster assembly (GO:0016226)	3.60480093
31	metallo-sulfur cluster assembly (GO:0031163)	3.60480093
32	GMP metabolic process (GO:0046037)	3.59835656
33	respiratory chain complex IV assembly (GO:0008535)	3.49423626
34	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	3.45951321
35	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	3.45951321
36	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	3.45913615
37	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.45102577
38	purine deoxyribonucleotide metabolic process (GO:0009151)	3.44090278
39	negative regulation of chemokine production (GO:0032682)	3.42797943
40	oxidative phosphorylation (GO:0006119)	3.41641368
41	inner mitochondrial membrane organization (GO:0007007)	3.40626093
42	regulation of chemokine biosynthetic process (GO:0045073)	3.40611524
43	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	3.39550949
44	blood vessel maturation (GO:0001955)	3.37936468
45	regulation of B cell apoptotic process (GO:0002902)	3.36549460
46	aggressive behavior (GO:0002118)	3.36004771
47	nucleosome disassembly (GO:0006337)	3.35856371
48	protein-DNA complex disassembly (GO:0032986)	3.35856371
49	axoneme assembly (GO:0035082)	3.34269194
50	phosphatidylglycerol biosynthetic process (GO:0006655)	3.33706412
51	regulation of actin nucleation (GO:0051125)	3.32542408
52	nonmotile primary cilium assembly (GO:0035058)	3.26734539
53	regulation of icosanoid secretion (GO:0032303)	3.25839311
54	forebrain morphogenesis (GO:0048853)	3.25587132
55	histone H3-K9 methylation (GO:0051567)	3.24262380
56	toxin transport (GO:1901998)	3.18815315
57	regulation of cilium movement (GO:0003352)	3.16764771
58	regulation of RIG-I signaling pathway (GO:0039535)	3.16506486
59	negative regulation of DNA-templated transcription, elongation (GO:0032785)	3.13105376
60	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	3.12344812
61	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	3.12344812
62	photoreceptor cell maintenance (GO:0045494)	3.11465260
63	rRNA catabolic process (GO:0016075)	3.11054150
64	regulation of protein kinase A signaling (GO:0010738)	3.11011617
65	adult feeding behavior (GO:0008343)	3.10479745
66	nucleoside diphosphate biosynthetic process (GO:0009133)	3.08836331
67	GPI anchor biosynthetic process (GO:0006506)	3.07001109
68	short-chain fatty acid metabolic process (GO:0046459)	3.04269735
69	protein polyglutamylation (GO:0018095)	3.03507538
70	protein localization to peroxisome (GO:0072662)	3.00711483
71	protein targeting to peroxisome (GO:0006625)	3.00711483
72	establishment of protein localization to peroxisome (GO:0072663)	3.00711483
73	cilium movement (GO:0003341)	2.99173810
74	cullin deneddylation (GO:0010388)	2.94939338
75	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.94894707
76	response to folic acid (GO:0051593)	2.94855194
77	protein prenylation (GO:0018342)	2.93281856
78	prenylation (GO:0097354)	2.93281856
79	purine nucleobase biosynthetic process (GO:0009113)	2.91348532
80	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.89300764
81	endothelium development (GO:0003158)	2.89182494
82	pentose metabolic process (GO:0019321)	2.85062463
83	artery smooth muscle contraction (GO:0014824)	2.83939381
84	cellular anion homeostasis (GO:0030002)	2.83546430
85	regulation of mitochondrial translation (GO:0070129)	2.82471632
86	actin nucleation (GO:0045010)	2.82296269
87	vascular smooth muscle contraction (GO:0014829)	2.81812407
88	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	2.81070471
89	GDP-mannose metabolic process (GO:0019673)	2.77941739
90	protein complex biogenesis (GO:0070271)	2.77658596
91	C-terminal protein amino acid modification (GO:0018410)	2.77521298
92	negative regulation of bone resorption (GO:0045779)	2.76324594
93	serine family amino acid catabolic process (GO:0009071)	2.76321876
94	negative regulation of multicellular organism growth (GO:0040015)	2.75480392
95	positive regulation of receptor biosynthetic process (GO:0010870)	2.75063380
96	poly(A)+ mRNA export from nucleus (GO:0016973)	2.72892615
97	dosage compensation (GO:0007549)	2.70595096
98	carnitine metabolic process (GO:0009437)	2.70261374
99	regulation of response to osmotic stress (GO:0047484)	2.70066567
100	epithelial cilium movement (GO:0003351)	2.69764504

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.81869059
2	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.17247613
3	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.17189719
4	TP63_17297297_ChIP-ChIP_HaCaT_Human	3.05569729
5	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	3.04697195
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.99192373
7	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.73032920
8	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.68690840
9	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.64755170
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.55000635
11	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.53379617
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.44172237
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.41542127
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.25822881
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.21189690
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.20707149
17	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.12471818
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.99971221
19	GABP_19822575_ChIP-Seq_HepG2_Human	1.98266496
20	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.95934007
21	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.93820247
22	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.92742446
23	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.81276379
24	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.80961632
25	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.80678180
26	KDM5A_27292631_Chip-Seq_BREAST_Human	1.80187236
27	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.80070523
28	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.74783071
29	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.69338191
30	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.69302528
31	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.66213618
32	VDR_23849224_ChIP-Seq_CD4+_Human	1.66014802
33	DCP1A_22483619_ChIP-Seq_HELA_Human	1.64463836
34	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63008895
35	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.61913066
36	ZNF263_19887448_ChIP-Seq_K562_Human	1.60848744
37	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.59188256
38	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.53894012
39	BCL6_27268052_Chip-Seq_Bcells_Human	1.53661771
40	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.53597990
41	SCL_19346495_ChIP-Seq_HPC-7_Human	1.52868413
42	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.50836211
43	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.49472427
44	CIITA_25753668_ChIP-Seq_RAJI_Human	1.48412493
45	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.47114238
46	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.45599768
47	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.44588131
48	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.44235185
49	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.42467603
50	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.36794922
51	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.35897907
52	FOXP3_21729870_ChIP-Seq_TREG_Human	1.34827874
53	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.29458136
54	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.28417256
55	PHF8_20622854_ChIP-Seq_HELA_Human	1.25789972
56	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.24708585
57	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.22335272
58	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.19189568
59	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.18008954
60	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.16853934
61	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.16410594
62	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.16276028
63	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.16275974
64	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.15465600
65	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.14991758
66	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.14409097
67	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.14301066
68	XRN2_22483619_ChIP-Seq_HELA_Human	1.13752949
69	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.13569183
70	TFEB_21752829_ChIP-Seq_HELA_Human	1.12948911
71	E2F1_20622854_ChIP-Seq_HELA_Human	1.11687959
72	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.11521174
73	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.10921825
74	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.10424176
75	ELK1_19687146_ChIP-ChIP_HELA_Human	1.10180948
76	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.09911963
77	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.09828783
78	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.06542125
79	BCOR_27268052_Chip-Seq_Bcells_Human	1.06466960
80	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.04402122
81	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.03744707
82	MAF_26560356_Chip-Seq_TH2_Human	1.03383851
83	UTX_26944678_Chip-Seq_JUKART_Human	1.02847887
84	TP53_22127205_ChIP-Seq_IMR90_Human	1.01967421
85	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.00542906
86	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.00542398
87	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.00183788
88	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.99979144
89	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.99248083
90	P300_27268052_Chip-Seq_Bcells_Human	0.99186490
91	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.98660036
92	P68_20966046_ChIP-Seq_HELA_Human	0.98597867
93	P53_21459846_ChIP-Seq_SAOS-2_Human	0.98125410
94	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.96298886
95	GATA1_19941826_ChIP-Seq_K562_Human	0.94629002
96	AR_20517297_ChIP-Seq_VCAP_Human	0.93197181
97	SMC4_20622854_ChIP-Seq_HELA_Human	0.92867400
98	VDR_21846776_ChIP-Seq_THP-1_Human	0.92140757
99	CTCF_20526341_ChIP-Seq_ESCs_Human	0.91978484
100	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.91552620

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	5.46470464
2	MP0005451_abnormal_body_composition	4.51498533
3	MP0009278_abnormal_bone_marrow	4.00877619
4	MP0000569_abnormal_digit_pigmentation	3.97021615
5	MP0005397_hematopoietic_system_phenotyp	3.95016584
6	MP0001545_abnormal_hematopoietic_system	3.95016584
7	MP0002638_abnormal_pupillary_reflex	3.28300903
8	MP0008260_abnormal_autophagy	3.16835095
9	MP0008995_early_reproductive_senescence	2.94153926
10	MP0002822_catalepsy	2.86946027
11	MP0003122_maternal_imprinting	2.82075459
12	MP0005645_abnormal_hypothalamus_physiol	2.56608576
13	MP0002938_white_spotting	2.29396165
14	MP0002653_abnormal_ependyma_morphology	2.03632428
15	MP0001984_abnormal_olfaction	2.02700898
16	MP0004858_abnormal_nervous_system	1.99563968
17	MP0009697_abnormal_copulation	1.98044697
18	MP0008877_abnormal_DNA_methylation	1.93522294
19	MP0006054_spinal_hemorrhage	1.90378593
20	MP0003172_abnormal_lysosome_physiology	1.87113562
21	MP0005174_abnormal_tail_pigmentation	1.86611548
22	MP0003787_abnormal_imprinting	1.81846849
23	MP0000465_gastrointestinal_hemorrhage	1.66490444
24	MP0006072_abnormal_retinal_apoptosis	1.62933468
25	MP0006035_abnormal_mitochondrial_morpho	1.59460042
26	MP0004133_heterotaxia	1.56081350
27	MP0005248_abnormal_Harderian_gland	1.55011993
28	MP0002095_abnormal_skin_pigmentation	1.47963175
29	MP0006292_abnormal_olfactory_placode	1.47561203
30	MP0001986_abnormal_taste_sensitivity	1.43736494
31	MP0001873_stomach_inflammation	1.39321693
32	MP0008058_abnormal_DNA_repair	1.33067016
33	MP0008789_abnormal_olfactory_epithelium	1.31968850
34	MP0000678_abnormal_parathyroid_gland	1.31158066
35	MP0004808_abnormal_hematopoietic_stem	1.30481769
36	MP0004782_abnormal_surfactant_physiolog	1.29221269
37	MP0003385_abnormal_body_wall	1.28590792
38	MP0005253_abnormal_eye_physiology	1.26314529
39	MP0005075_abnormal_melanosome_morpholog	1.25302172
40	MP0000681_abnormal_thyroid_gland	1.22475474
41	MP0005171_absent_coat_pigmentation	1.20722672
42	MP0006036_abnormal_mitochondrial_physio	1.19074039
43	MP0008007_abnormal_cellular_replicative	1.18241298
44	MP0005083_abnormal_biliary_tract	1.17037874
45	MP0000639_abnormal_adrenal_gland	1.16619492
46	MP0003786_premature_aging	1.16260846
47	MP0002971_abnormal_brown_adipose	1.15868904
48	MP0008872_abnormal_physiological_respon	1.15071499
49	MP0003941_abnormal_skin_development	1.12552402
50	MP0002396_abnormal_hematopoietic_system	1.12288483
51	MP0002254_reproductive_system_inflammat	1.11743540
52	MP0005220_abnormal_exocrine_pancreas	1.11677699
53	MP0005499_abnormal_olfactory_system	1.10415904
54	MP0005394_taste/olfaction_phenotype	1.10415904
55	MP0009764_decreased_sensitivity_to	1.05610772
56	MP0002090_abnormal_vision	1.04769563
57	MP0001270_distended_abdomen	1.03302079
58	MP0005410_abnormal_fertilization	1.01057123
59	MP0005551_abnormal_eye_electrophysiolog	0.99595995
60	MP0002009_preneoplasia	0.92760182
61	MP0000631_abnormal_neuroendocrine_gland	0.91145315
62	MP0000026_abnormal_inner_ear	0.85746041
63	MP0005535_abnormal_body_temperature	0.83408331
64	MP0002006_tumorigenesis	0.81877559
65	MP0003948_abnormal_gas_homeostasis	0.79428750
66	MP0002909_abnormal_adrenal_gland	0.77719714
67	MP0004859_abnormal_synaptic_plasticity	0.76043059
68	MP0001727_abnormal_embryo_implantation	0.74917106
69	MP0001188_hyperpigmentation	0.73398438
70	MP0003077_abnormal_cell_cycle	0.72292806
71	MP0008932_abnormal_embryonic_tissue	0.70429316
72	MP0003698_abnormal_male_reproductive	0.69353850
73	MP0000516_abnormal_urinary_system	0.67623262
74	MP0005367_renal/urinary_system_phenotyp	0.67623262
75	MP0008873_increased_physiological_sensi	0.66704811
76	MP0000049_abnormal_middle_ear	0.66655957
77	MP0005646_abnormal_pituitary_gland	0.65744608
78	MP0001929_abnormal_gametogenesis	0.64302141
79	MP0001661_extended_life_span	0.64147822
80	MP0003111_abnormal_nucleus_morphology	0.61997960
81	MP0010307_abnormal_tumor_latency	0.61703732
82	MP0001963_abnormal_hearing_physiology	0.60461922
83	MP0001905_abnormal_dopamine_level	0.59831534
84	MP0010368_abnormal_lymphatic_system	0.59236404
85	MP0000015_abnormal_ear_pigmentation	0.58923916
86	MP0005408_hypopigmentation	0.58106147
87	MP0002019_abnormal_tumor_incidence	0.57622773
88	MP0005501_abnormal_skin_physiology	0.56333115
89	MP0009115_abnormal_fat_cell	0.55209369
90	MP0001835_abnormal_antigen_presentation	0.53470817
91	MP0004019_abnormal_vitamin_homeostasis	0.53215595
92	MP0003136_yellow_coat_color	0.52649654
93	MP0009384_cardiac_valve_regurgitation	0.52441077
94	MP0002751_abnormal_autonomic_nervous	0.51149318
95	MP0003937_abnormal_limbs/digits/tail_de	0.50776129
96	MP0002233_abnormal_nose_morphology	0.49534219
97	MP0009046_muscle_twitch	0.47989623
98	MP0002722_abnormal_immune_system	0.47956839
99	MP0005391_vision/eye_phenotype	0.47485279
100	MP0005310_abnormal_salivary_gland	0.47439052

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Microvesicular hepatic steatosis (HP:0001414)	6.55685032
2	Type I transferrin isoform profile (HP:0003642)	4.53870082
3	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	4.26865892
4	Abnormal protein N-linked glycosylation (HP:0012347)	4.26865892
5	Abnormal protein glycosylation (HP:0012346)	4.26865892
6	Abnormal glycosylation (HP:0012345)	4.26865892
7	Granulocytopenia (HP:0001913)	4.24585480
8	Reduced antithrombin III activity (HP:0001976)	3.80216376
9	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.76467179
10	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.76467179
11	Thrombocytosis (HP:0001894)	3.64640624
12	Spastic paraparesis (HP:0002313)	3.50456095
13	Congenital primary aphakia (HP:0007707)	3.21441611
14	Agammaglobulinemia (HP:0004432)	3.11178427
15	Neoplasm of the adrenal cortex (HP:0100641)	3.08935372
16	Gait imbalance (HP:0002141)	3.08184072
17	Medial flaring of the eyebrow (HP:0010747)	3.03201278
18	Progressive microcephaly (HP:0000253)	2.94632969
19	Eosinophilia (HP:0001880)	2.87143282
20	Hyperglycinemia (HP:0002154)	2.78747654
21	Nephrogenic diabetes insipidus (HP:0009806)	2.77875255
22	Hepatic necrosis (HP:0002605)	2.74874915
23	Hypoplasia of the pons (HP:0012110)	2.74238211
24	Hepatocellular necrosis (HP:0001404)	2.73611463
25	White forelock (HP:0002211)	2.71396913
26	Brushfield spots (HP:0001088)	2.69391912
27	3-Methylglutaconic aciduria (HP:0003535)	2.66516013
28	Short 5th finger (HP:0009237)	2.64162601
29	Disproportionate short-trunk short stature (HP:0003521)	2.61058087
30	Spinal cord lesions (HP:0100561)	2.60456209
31	Syringomyelia (HP:0003396)	2.60456209
32	Anteriorly placed anus (HP:0001545)	2.60300060
33	Abnormality of the periventricular white matter (HP:0002518)	2.51224411
34	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	2.45437766
35	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.31817534
36	Dicarboxylic aciduria (HP:0003215)	2.31817534
37	Poor coordination (HP:0002370)	2.30840522
38	Abnormality of fatty-acid metabolism (HP:0004359)	2.30789644
39	Abnormality of eosinophils (HP:0001879)	2.28731980
40	Neoplasm of the adrenal gland (HP:0100631)	2.26567999
41	Genital tract atresia (HP:0001827)	2.25773145
42	Generalized aminoaciduria (HP:0002909)	2.22736460
43	Patchy hypopigmentation of hair (HP:0011365)	2.22712480
44	Broad foot (HP:0001769)	2.18347409
45	IgM deficiency (HP:0002850)	2.16790928
46	Attenuation of retinal blood vessels (HP:0007843)	2.16004081
47	Abnormality of the pons (HP:0007361)	2.12845266
48	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.09903561
49	Retinitis pigmentosa (HP:0000510)	2.09647355
50	Vaginal atresia (HP:0000148)	2.09210309
51	Nephronophthisis (HP:0000090)	2.08030082
52	Pulmonary artery stenosis (HP:0004415)	2.06348373
53	Cortical visual impairment (HP:0100704)	2.05051688
54	Hyperglycinuria (HP:0003108)	2.04852950
55	Aplastic anemia (HP:0001915)	1.99585429
56	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.99370870
57	Ragged-red muscle fibers (HP:0003200)	1.99183950
58	Albinism (HP:0001022)	1.98254111
59	Rhabdomyolysis (HP:0003201)	1.97985656
60	Diastasis recti (HP:0001540)	1.97260093
61	Genetic anticipation (HP:0003743)	1.96589190
62	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.94590318
63	Absent epiphyses (HP:0010577)	1.94590318
64	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.93037927
65	Heterochromia iridis (HP:0001100)	1.92407168
66	Microglossia (HP:0000171)	1.92252463
67	Emotional lability (HP:0000712)	1.92160868
68	Cutaneous melanoma (HP:0012056)	1.89735448
69	Severe global developmental delay (HP:0011344)	1.89654098
70	Opisthotonus (HP:0002179)	1.88086856
71	Acute hepatic failure (HP:0006554)	1.87750635
72	Periodontitis (HP:0000704)	1.86782716
73	Panhypogammaglobulinemia (HP:0003139)	1.85265140
74	Supernumerary spleens (HP:0009799)	1.84119080
75	Metaphyseal dysplasia (HP:0100255)	1.83229219
76	Peripheral primitive neuroectodermal neoplasm (HP:0030067)	1.82579120
77	Neuroblastoma (HP:0003006)	1.82579120
78	Primitive neuroectodermal tumor (HP:0030065)	1.82579120
79	Neuroblastic tumors (HP:0004376)	1.82579120
80	Postaxial foot polydactyly (HP:0001830)	1.80850660
81	Ovoid vertebral bodies (HP:0003300)	1.78856998
82	Prolonged neonatal jaundice (HP:0006579)	1.77083625
83	Reticulocytosis (HP:0001923)	1.76432164
84	Supernumerary ribs (HP:0005815)	1.73574453
85	Lipid accumulation in hepatocytes (HP:0006561)	1.72989771
86	Urethral obstruction (HP:0000796)	1.72454483
87	Pancreatic fibrosis (HP:0100732)	1.70876190
88	Supernumerary bones of the axial skeleton (HP:0009144)	1.70711936
89	Pancreatic cysts (HP:0001737)	1.70380624
90	Erythema (HP:0010783)	1.69932440
91	Tubulointerstitial nephritis (HP:0001970)	1.69266205
92	Constricted visual fields (HP:0001133)	1.67027624
93	Increased muscle lipid content (HP:0009058)	1.67008857
94	Ureteral stenosis (HP:0000071)	1.66802743
95	Fatigue (HP:0012378)	1.66218928
96	Cellular immunodeficiency (HP:0005374)	1.64629754
97	Dyskinesia (HP:0100660)	1.64419930
98	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.61971898
99	Severe muscular hypotonia (HP:0006829)	1.61900705
100	Aganglionic megacolon (HP:0002251)	1.61564358

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PIM2	6.73256070
2	ZAK	6.18596057
3	TAOK3	3.38513925
4	TESK2	2.88359408
5	SCYL2	2.87542497
6	KIT	2.81108977
7	DYRK1B	2.79740357
8	SRPK1	2.53458163
9	BCKDK	2.22668328
10	DYRK3	2.12364350
11	TLK1	2.08500699
12	MAP4K2	2.03500003
13	CDK6	1.92157874
14	KDR	1.89389882
15	PIM1	1.89375994
16	GRK6	1.89028525
17	MAP2K7	1.88016169
18	BMPR2	1.80431733
19	CCNB1	1.67432330
20	CSNK1G3	1.66758992
21	TESK1	1.61903238
22	AKT3	1.54317837
23	JAK3	1.49564420
24	CSNK1A1L	1.46596453
25	MAP3K4	1.46501806
26	BMPR1B	1.38396760
27	NUAK1	1.36827385
28	CDK12	1.35462067
29	MAP3K5	1.29847752
30	MAPKAPK3	1.26886983
31	MAPK13	1.13028418
32	CSNK1G2	1.10733042
33	FRK	1.09529605
34	MAPK11	1.04707043
35	DAPK1	1.03167435
36	CSNK1G1	1.00788169
37	LIMK1	1.00622090
38	BCR	0.99047545
39	FGFR2	0.98511217
40	CDK19	0.97868432
41	CDK9	0.97735981
42	NTRK2	0.96488542
43	PLK2	0.91966980
44	RPS6KA5	0.91539145
45	ATR	0.83025476
46	MAP4K1	0.81283844
47	FLT3	0.76186957
48	MAP3K6	0.74614830
49	NEK9	0.73393318
50	VRK1	0.72759394
51	IRAK3	0.71670059
52	LCK	0.71077155
53	SIK3	0.70068710
54	TNIK	0.65982365
55	EPHA3	0.65475235
56	TNK2	0.65121721
57	ADRBK2	0.60657906
58	BRD4	0.52246996
59	RPS6KA4	0.51587993
60	DAPK3	0.50413091
61	PRKAA1	0.46664825
62	LRRK2	0.46492080
63	AURKA	0.45927597
64	LATS1	0.45842479
65	PINK1	0.45658540
66	CDK8	0.45563314
67	MATK	0.43913402
68	CHUK	0.43379129
69	SYK	0.41818839
70	BTK	0.39041148
71	RAF1	0.36215386
72	CHEK2	0.35215191
73	PLK1	0.34291011
74	ITK	0.33887748
75	PLK4	0.33767221
76	MKNK1	0.33357837
77	PKN1	0.33007445
78	LYN	0.30155740
79	TEC	0.29866222
80	VRK2	0.27024174
81	IKBKB	0.26959642
82	CLK1	0.26467943
83	AKT2	0.22617059
84	NME2	0.22507762
85	GRK7	0.22175060
86	PLK3	0.20448730
87	CSNK2A1	0.19795423
88	PRKCE	0.19578403
89	TGFBR1	0.18332047
90	MAPK3	0.18156039
91	PRKAA2	0.16963763
92	MAP2K4	0.16754144
93	IKBKE	0.15924876
94	NEK2	0.15388812
95	CDK2	0.14652064
96	CSNK1D	0.14008713
97	AKT1	0.13898863
98	CDK14	0.13648881
99	FER	0.13501110
100	CAMK1	0.13290775

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.17665909
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	4.14915185
3	Butanoate metabolism_Homo sapiens_hsa00650	3.53574654
4	Glycosaminoglycan degradation_Homo sapiens_hsa00531	3.11822873
5	Base excision repair_Homo sapiens_hsa03410	2.95497059
6	Steroid biosynthesis_Homo sapiens_hsa00100	2.40713661
7	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.40612088
8	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.23467409
9	Propanoate metabolism_Homo sapiens_hsa00640	2.05264449
10	Primary immunodeficiency_Homo sapiens_hsa05340	1.97279814
11	Fatty acid elongation_Homo sapiens_hsa00062	1.95661198
12	RNA polymerase_Homo sapiens_hsa03020	1.95367877
13	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.86953359
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.79437331
15	Folate biosynthesis_Homo sapiens_hsa00790	1.77719159
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.76230229
17	Fatty acid metabolism_Homo sapiens_hsa01212	1.73470453
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.72101681
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.65516816
20	Lysine degradation_Homo sapiens_hsa00310	1.63932358
21	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.62753178
22	Carbon metabolism_Homo sapiens_hsa01200	1.60840603
23	p53 signaling pathway_Homo sapiens_hsa04115	1.46455952
24	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.43184880
25	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.43034822
26	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.42798934
27	Regulation of autophagy_Homo sapiens_hsa04140	1.41088551
28	Spliceosome_Homo sapiens_hsa03040	1.28190211
29	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.27333654
30	Pentose phosphate pathway_Homo sapiens_hsa00030	1.27213792
31	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.25563373
32	Basal transcription factors_Homo sapiens_hsa03022	1.20642993
33	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.16583162
34	Purine metabolism_Homo sapiens_hsa00230	1.15809162
35	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.14778028
36	Proteasome_Homo sapiens_hsa03050	1.14280084
37	Nucleotide excision repair_Homo sapiens_hsa03420	1.13105765
38	Olfactory transduction_Homo sapiens_hsa04740	1.11956682
39	Peroxisome_Homo sapiens_hsa04146	1.11155677
40	Pyruvate metabolism_Homo sapiens_hsa00620	1.08142214
41	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.07984025
42	Fanconi anemia pathway_Homo sapiens_hsa03460	1.03873725
43	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.03080057
44	Huntingtons disease_Homo sapiens_hsa05016	1.01548585
45	Parkinsons disease_Homo sapiens_hsa05012	1.00453515
46	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.00384935
47	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.94031835
48	Notch signaling pathway_Homo sapiens_hsa04330	0.93841650
49	RNA transport_Homo sapiens_hsa03013	0.92955246
50	Alcoholism_Homo sapiens_hsa05034	0.91592088
51	Sulfur relay system_Homo sapiens_hsa04122	0.89894859
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87399215
53	Homologous recombination_Homo sapiens_hsa03440	0.87011273
54	Pyrimidine metabolism_Homo sapiens_hsa00240	0.86141334
55	Metabolic pathways_Homo sapiens_hsa01100	0.83676580
56	Fatty acid degradation_Homo sapiens_hsa00071	0.81764784
57	Oxidative phosphorylation_Homo sapiens_hsa00190	0.79714056
58	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.78766480
59	Antigen processing and presentation_Homo sapiens_hsa04612	0.75700067
60	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.73874076
61	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.73622988
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.72454978
63	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.71425738
64	Nicotine addiction_Homo sapiens_hsa05033	0.70312959
65	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.67099615
66	Other glycan degradation_Homo sapiens_hsa00511	0.65547843
67	ABC transporters_Homo sapiens_hsa02010	0.61666494
68	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.59715247
69	Shigellosis_Homo sapiens_hsa05131	0.59187998
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57840285
71	mRNA surveillance pathway_Homo sapiens_hsa03015	0.57197996
72	Lysosome_Homo sapiens_hsa04142	0.56995419
73	Tryptophan metabolism_Homo sapiens_hsa00380	0.45873849
74	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.44599257
75	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.43565659
76	Nitrogen metabolism_Homo sapiens_hsa00910	0.42293595
77	Alzheimers disease_Homo sapiens_hsa05010	0.40763319
78	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.39137473
79	One carbon pool by folate_Homo sapiens_hsa00670	0.38680715
80	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.38430305
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37995722
82	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.36735587
83	Histidine metabolism_Homo sapiens_hsa00340	0.36361987
84	Basal cell carcinoma_Homo sapiens_hsa05217	0.32473359
85	Asthma_Homo sapiens_hsa05310	0.31923881
86	Wnt signaling pathway_Homo sapiens_hsa04310	0.30758500
87	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.30168139
88	Renin-angiotensin system_Homo sapiens_hsa04614	0.30105418
89	beta-Alanine metabolism_Homo sapiens_hsa00410	0.29831453
90	Taste transduction_Homo sapiens_hsa04742	0.27730255
91	Linoleic acid metabolism_Homo sapiens_hsa00591	0.27543117
92	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.27292059
93	mTOR signaling pathway_Homo sapiens_hsa04150	0.27144917
94	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.25671147
95	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.24404034
96	RNA degradation_Homo sapiens_hsa03018	0.24143696
97	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.23439474
98	GABAergic synapse_Homo sapiens_hsa04727	0.23358940
99	Oocyte meiosis_Homo sapiens_hsa04114	0.20820879
100	Herpes simplex infection_Homo sapiens_hsa05168	0.20628989

FAM86MP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »