FAM89B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)6.43743115
2Arp2/3 complex-mediated actin nucleation (GO:0034314)5.20452682
3barbed-end actin filament capping (GO:0051016)4.64469024
4regulation of protein heterodimerization activity (GO:0043497)4.57972621
5negative regulation of erythrocyte differentiation (GO:0045647)4.34892744
6neutrophil activation involved in immune response (GO:0002283)4.33396391
7actin nucleation (GO:0045010)3.88017032
8positive regulation by symbiont of host defense response (GO:0052509)3.69643524
9modulation by symbiont of host defense response (GO:0052031)3.69643524
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.69643524
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.69643524
12positive regulation by organism of defense response of other organism involved in symbiotic interact3.69643524
13modulation by symbiont of host immune response (GO:0052553)3.69643524
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.64739672
15negative regulation of cell killing (GO:0031342)3.64739672
16respiratory burst (GO:0045730)3.57110955
17endosome to pigment granule transport (GO:0043485)3.49876532
18endosome to melanosome transport (GO:0035646)3.49876532
19negative regulation of phagocytosis (GO:0050765)3.42990426
20cellular response to nicotine (GO:0071316)3.03996715
21pyrimidine nucleobase catabolic process (GO:0006208)3.02497263
22modulation by virus of host process (GO:0019054)2.96888018
23modulation by symbiont of host cellular process (GO:0044068)2.86257126
24viral protein processing (GO:0019082)2.84412256
25negative regulation of glial cell proliferation (GO:0060253)2.84160496
26regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.84158529
27activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.82825501
28mannose metabolic process (GO:0006013)2.82468492
29regulation of mast cell degranulation (GO:0043304)2.82381609
30response to muramyl dipeptide (GO:0032495)2.81016209
31antigen processing and presentation via MHC class Ib (GO:0002475)2.79987698
32negative regulation of calcium ion transport into cytosol (GO:0010523)2.78719007
33positive regulation of macrophage differentiation (GO:0045651)2.78069414
34positive regulation of myotube differentiation (GO:0010831)2.75607827
35neutrophil activation (GO:0042119)2.75076523
36regulation of skeletal muscle contraction (GO:0014819)2.72592214
37regulation of leukocyte degranulation (GO:0043300)2.72251303
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.71030741
39response to host immune response (GO:0052572)2.69338505
40response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.69338505
41regulation of myeloid leukocyte mediated immunity (GO:0002886)2.67596618
42positive regulation of antigen processing and presentation (GO:0002579)2.67223124
43sarcoplasmic reticulum calcium ion transport (GO:0070296)2.66438742
44regulation of histone phosphorylation (GO:0033127)2.66128370
45regulation of B cell receptor signaling pathway (GO:0050855)2.65900760
46regulation of necrotic cell death (GO:0010939)2.64679349
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.62562269
48virion assembly (GO:0019068)2.62257348
49negative regulation of microtubule polymerization (GO:0031115)2.60857418
50membrane budding (GO:0006900)2.60713601
51granulocyte activation (GO:0036230)2.60385730
52platelet dense granule organization (GO:0060155)2.59912088
53detection of bacterium (GO:0016045)2.59863058
54negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.59783386
55regulation of regulated secretory pathway (GO:1903305)2.59155764
56antigen processing and presentation of endogenous antigen (GO:0019883)2.59116945
57antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.59083458
58cellular response to zinc ion (GO:0071294)2.58532977
59detection of other organism (GO:0098543)2.58491857
60adenosine receptor signaling pathway (GO:0001973)2.56637080
61respiratory system process (GO:0003016)2.56549849
62neurofilament cytoskeleton organization (GO:0060052)2.55603288
63regulation of ARF GTPase activity (GO:0032312)2.55208834
64neuron projection extension involved in neuron projection guidance (GO:1902284)2.55075010
65axon extension involved in axon guidance (GO:0048846)2.55075010
66negative regulation of myeloid cell apoptotic process (GO:0033033)2.54745411
67negative regulation of necrotic cell death (GO:0060547)2.53898109
68regulation of monocyte chemotaxis (GO:0090025)2.53694608
69response to host (GO:0075136)2.52066010
70response to host defenses (GO:0052200)2.52066010
71response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.52066010
72regulation of early endosome to late endosome transport (GO:2000641)2.50672954
73macrophage activation involved in immune response (GO:0002281)2.48371886
74NIK/NF-kappaB signaling (GO:0038061)2.46704637
75immunoglobulin mediated immune response (GO:0016064)2.46059244
76negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.45428600
77response to peptidoglycan (GO:0032494)2.45186693
78positive regulation of T cell apoptotic process (GO:0070234)2.44560214
79response to parathyroid hormone (GO:0071107)2.43695884
80regulation of antigen processing and presentation (GO:0002577)2.43482638
81establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.43319387
82mitochondrion transport along microtubule (GO:0047497)2.43319387
83cell migration in hindbrain (GO:0021535)2.43179194
84antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.43061980
85positive regulation of Cdc42 GTPase activity (GO:0043089)2.42718025
86regulation of mast cell activation involved in immune response (GO:0033006)2.42437200
87G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.42233529
88anterograde synaptic vesicle transport (GO:0048490)2.41411318
89protein localization to endosome (GO:0036010)2.40702587
90lipopolysaccharide metabolic process (GO:0008653)2.39999834
91regulation of interferon-beta biosynthetic process (GO:0045357)2.39438721
92regulation of ARF protein signal transduction (GO:0032012)2.39099505
93creatine metabolic process (GO:0006600)2.38917000
94regulation of MHC class II biosynthetic process (GO:0045346)2.38727529
95lipopolysaccharide biosynthetic process (GO:0009103)2.38188609
96leukocyte aggregation (GO:0070486)2.37647942
97peripheral nervous system neuron development (GO:0048935)2.37140948
98stress fiber assembly (GO:0043149)2.36692506
99membrane invagination (GO:0010324)2.36387662
100actin-myosin filament sliding (GO:0033275)2.35343446
101muscle filament sliding (GO:0030049)2.35343446
102antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.34708552
103purine-containing compound salvage (GO:0043101)2.34148383
104histamine secretion (GO:0001821)2.32423074
105positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.32017526
106positive thymic T cell selection (GO:0045059)2.31617337
107lipopolysaccharide-mediated signaling pathway (GO:0031663)2.30240683
108detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.30114601
109detection of temperature stimulus involved in sensory perception (GO:0050961)2.30114601
110positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.30052984
111regulation of NFAT protein import into nucleus (GO:0051532)2.28141469
112positive regulation of extracellular matrix organization (GO:1903055)2.28006630
113negative regulation of leukocyte chemotaxis (GO:0002689)2.27546913
114negative regulation of interleukin-12 production (GO:0032695)2.27477978
115myeloid cell homeostasis (GO:0002262)2.27356993
116positive regulation of lymphocyte apoptotic process (GO:0070230)2.27130413
117antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.26940281
118enteric nervous system development (GO:0048484)2.26799857
119positive regulation of gamma-delta T cell activation (GO:0046645)2.26394277
120phagocytosis, engulfment (GO:0006911)2.25057762
121regulation of T-helper 2 cell differentiation (GO:0045628)2.24948446
122viral transcription (GO:0019083)2.24524012
123regulation of defense response to virus by virus (GO:0050690)2.22340508
124membrane protein intracellular domain proteolysis (GO:0031293)2.22265819
125positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.22205260
126de novo posttranslational protein folding (GO:0051084)2.22138851
127establishment of mitochondrion localization (GO:0051654)2.21551838
128myeloid cell activation involved in immune response (GO:0002275)2.21364469
129amino sugar catabolic process (GO:0046348)2.20684995
130positive regulation of chemokine biosynthetic process (GO:0045080)2.20300171
131positive regulation of lamellipodium assembly (GO:0010592)2.20103181
132positive regulation of mast cell activation (GO:0033005)2.19998955
133nucleobase catabolic process (GO:0046113)2.19979347
134modulation by virus of host morphology or physiology (GO:0019048)2.19619351
135actin filament polymerization (GO:0030041)2.19149128
136detection of molecule of bacterial origin (GO:0032490)2.17746904
137germinal center formation (GO:0002467)2.16620894
138positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.16192540
139positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.15578199
140negative regulation of cAMP-mediated signaling (GO:0043951)2.15542118
141platelet aggregation (GO:0070527)2.14583316
142positive regulation of interferon-alpha production (GO:0032727)2.14565707
143negative regulation of cell size (GO:0045792)2.14507762
144regulation of dendritic cell antigen processing and presentation (GO:0002604)2.14428430
145negative regulation of actin filament polymerization (GO:0030837)2.13793738
146tooth mineralization (GO:0034505)2.13768715
147response to nerve growth factor (GO:1990089)2.13409072
148cellular response to nerve growth factor stimulus (GO:1990090)2.13409072
149positive regulation of histone deacetylation (GO:0031065)2.13172355
150facial nerve structural organization (GO:0021612)2.13050579
151regulation of chemokine-mediated signaling pathway (GO:0070099)2.12948606
152positive regulation of monocyte chemotaxis (GO:0090026)2.12885042
153negative regulation of nitric oxide biosynthetic process (GO:0045019)2.12491559
154cellular extravasation (GO:0045123)2.12488071
155deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.11923389
156negative regulation of granulocyte differentiation (GO:0030853)2.10689170
157positive regulation of fibroblast migration (GO:0010763)2.09587180
158regulation of female receptivity (GO:0045924)2.09220637
159negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.08988759
160G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.08777513
161pigment granule organization (GO:0048753)2.08090823
162leukocyte cell-cell adhesion (GO:0007159)2.07870532
163melanosome organization (GO:0032438)2.07849931
164positive regulation of mast cell activation involved in immune response (GO:0033008)2.07656658
165positive regulation of mast cell degranulation (GO:0043306)2.07656658
166cell-cell junction maintenance (GO:0045217)2.07427083
167cellular response to thyroid hormone stimulus (GO:0097067)2.07374150
168negative regulation of necroptotic process (GO:0060546)2.07263066
169regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.06870048
170positive regulation of regulated secretory pathway (GO:1903307)2.06811764
171positive regulation of blood vessel endothelial cell migration (GO:0043536)2.05754820

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse3.19515636
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.14674737
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.14227417
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.90665245
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.87550678
6VDR_21846776_ChIP-Seq_THP-1_Human2.76018072
7SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.69598818
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.69559791
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62104318
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.59497272
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.46266986
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.45824856
13CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.28151419
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.25162808
15* ELK3_25401928_ChIP-Seq_HUVEC_Human2.17708296
16ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.16338537
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.16235945
18VDR_24763502_ChIP-Seq_THP-1_Human2.12529365
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11978508
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.11400527
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.07336175
22KDM2B_26808549_Chip-Seq_K562_Human2.06446019
23RACK7_27058665_Chip-Seq_MCF-7_Human2.05238788
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.02549690
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.01248899
26MYC_22102868_ChIP-Seq_BL_Human2.00976008
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98778293
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.94603356
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94471802
30SPI1_23547873_ChIP-Seq_NB4_Human1.92755339
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.92674983
32CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.90095299
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87337424
34MAF_26560356_Chip-Seq_TH1_Human1.86271325
35P68_20966046_ChIP-Seq_HELA_Human1.84916116
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84828254
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.84635550
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81691530
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79452579
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78887119
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.78574102
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.76305465
43LXR_22292898_ChIP-Seq_THP-1_Human1.71306652
44SCL_19346495_ChIP-Seq_HPC-7_Human1.70721457
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.70161434
46CTCF_27219007_Chip-Seq_ERYTHROID_Human1.69823620
47* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.68572038
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.68174646
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.62358219
50UTX_26944678_Chip-Seq_JUKART_Human1.62236056
51CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.58023962
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57259547
53XRN2_22483619_ChIP-Seq_HELA_Human1.57196712
54* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57091595
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55022917
56* CTCF_27219007_Chip-Seq_Bcells_Human1.53324873
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.52072992
58SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.51610889
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49781347
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.49713062
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49532297
62MYB_26560356_Chip-Seq_TH2_Human1.49376164
63SMC4_20622854_ChIP-Seq_HELA_Human1.48528056
64TP63_17297297_ChIP-ChIP_HaCaT_Human1.48176363
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47771099
66HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.47306165
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.44278552
68BCOR_27268052_Chip-Seq_Bcells_Human1.43659275
69CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43071431
70EZH2_22144423_ChIP-Seq_EOC_Human1.42676250
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42112458
72SPI1_23127762_ChIP-Seq_K562_Human1.41640107
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39274210
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.38260639
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35273573
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34909639
77MAF_26560356_Chip-Seq_TH2_Human1.33006203
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32266592
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30969072
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.30539648
81BCL6_27268052_Chip-Seq_Bcells_Human1.30312814
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28974269
83ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.28658041
84CREB1_26743006_Chip-Seq_LNCaP_Human1.28635067
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28503747
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28202487
87SA1_27219007_Chip-Seq_Bcells_Human1.27532764
88* KDM2B_26808549_Chip-Seq_DND41_Human1.26718677
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25889280
90HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25848737
91TCF7_22412390_ChIP-Seq_EML_Mouse1.24985180
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.24845063
93STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.24211900
94SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23978549
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23657349
96CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23381080
97* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.23120072
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22858344
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22167199
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.21334768
101YY1_22570637_ChIP-Seq_MALME-3M_Human1.21189895
102JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20667513
103PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20038787
104HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19435623
105TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19306751
106ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17469441
107SPI1_20517297_ChIP-Seq_HL60_Human1.17456334
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17042579
109UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16864888
110SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15881763
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14950332
112CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14690320
113LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14662926
114CTCF_21964334_ChIP-Seq_BJAB-B_Human1.14399654
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14120537
116TET1_21451524_ChIP-Seq_MESCs_Mouse1.13842195
117TFEB_21752829_ChIP-Seq_HELA_Human1.13352444
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13326519
119E2F1_20622854_ChIP-Seq_HELA_Human1.13275883
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13192400
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12853444
122DCP1A_22483619_ChIP-Seq_HELA_Human1.11566981
123PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11014305
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09212301
125E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09034268
126CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08347432
127CTCF_21964334_Chip-Seq_Bcells_Human1.07716525
128PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07395773
129IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05849601
130RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05375182
131CTCF_26484167_Chip-Seq_Bcells_Mouse1.04433742
132* TP63_22573176_ChIP-Seq_HFKS_Human1.04238733
133WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04046422
134SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03851089
135* SA1_27219007_Chip-Seq_ERYTHROID_Human1.03117168
136P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02715369
137EZH2_27294783_Chip-Seq_ESCs_Mouse1.02576478
138NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02460320
139MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02089087
140SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02046389
141DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01546154
142PHF8_20622854_ChIP-Seq_HELA_Human1.01399692
143PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00815988
144TP53_22127205_ChIP-Seq_IMR90_Human1.00721823
145GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98937279
146STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98558911
147ELK1_22589737_ChIP-Seq_MCF10A_Human0.98343117
148ETS1_20019798_ChIP-Seq_JURKAT_Human0.98316899
149RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98264307
150* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98205433
151OCT4_19829295_ChIP-Seq_ESCs_Human0.97998143
152OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95670938
153TTF2_22483619_ChIP-Seq_HELA_Human0.95608310

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.65775507
2MP0008438_abnormal_cutaneous_collagen3.41412705
3MP0003436_decreased_susceptibility_to3.04811553
4MP0001835_abnormal_antigen_presentation2.73359712
5MP0003191_abnormal_cellular_cholesterol2.40520826
6MP0004858_abnormal_nervous_system2.31109547
7MP0009840_abnormal_foam_cell2.22211940
8MP0000685_abnormal_immune_system2.21824778
9MP0000751_myopathy2.20935160
10MP0002148_abnormal_hypersensitivity_rea2.19589770
11MP0002735_abnormal_chemical_nociception2.18862457
12MP0005000_abnormal_immune_tolerance2.16690116
13MP0005058_abnormal_lysosome_morphology2.15735163
14MP0004130_abnormal_muscle_cell2.08286960
15MP0009785_altered_susceptibility_to2.00295264
16MP0002419_abnormal_innate_immunity2.00003886
17MP0004145_abnormal_muscle_electrophysio1.96756360
18MP0006054_spinal_hemorrhage1.96379608
19MP0009333_abnormal_splenocyte_physiolog1.94860918
20MP0006276_abnormal_autonomic_nervous1.94505765
21MP0004859_abnormal_synaptic_plasticity1.94499514
22MP0005025_abnormal_response_to1.93909120
23MP0001958_emphysema1.90860341
24MP0003123_paternal_imprinting1.83340572
25MP0002405_respiratory_system_inflammati1.82390514
26MP0003279_aneurysm1.80049943
27MP0005174_abnormal_tail_pigmentation1.78431874
28MP0002452_abnormal_antigen_presenting1.73348321
29MP0000749_muscle_degeneration1.72837232
30MP0009278_abnormal_bone_marrow1.72631464
31MP0006082_CNS_inflammation1.72201795
32MP0002751_abnormal_autonomic_nervous1.71166762
33MP0000569_abnormal_digit_pigmentation1.70507380
34MP0001533_abnormal_skeleton_physiology1.69912427
35MP0010030_abnormal_orbit_morphology1.69843131
36MP0000343_altered_response_to1.68977010
37MP0000750_abnormal_muscle_regeneration1.67643083
38MP0000858_altered_metastatic_potential1.66804152
39MP0002420_abnormal_adaptive_immunity1.66291406
40MP0003656_abnormal_erythrocyte_physiolo1.65977401
41MP0001819_abnormal_immune_cell1.65866864
42MP0001348_abnormal_lacrimal_gland1.65478673
43MP0008260_abnormal_autophagy1.64328600
44MP0005503_abnormal_tendon_morphology1.62876020
45MP0001790_abnormal_immune_system1.62487819
46MP0005387_immune_system_phenotype1.62487819
47MP0004510_myositis1.59513223
48MP0000759_abnormal_skeletal_muscle1.54854228
49MP0005671_abnormal_response_to1.54364875
50MP0002723_abnormal_immune_serum1.53386890
51MP0000015_abnormal_ear_pigmentation1.52555437
52MP0003300_gastrointestinal_ulcer1.51046930
53MP0003075_altered_response_to1.50207069
54MP0002822_catalepsy1.49830566
55MP0005464_abnormal_platelet_physiology1.47678969
56MP0002132_abnormal_respiratory_system1.46957684
57MP0002398_abnormal_bone_marrow1.41282608
58MP0001800_abnormal_humoral_immune1.39384152
59MP0003879_abnormal_hair_cell1.39267752
60MP0003329_amyloid_beta_deposits1.38898311
61MP0000465_gastrointestinal_hemorrhage1.38066950
62MP0002933_joint_inflammation1.37543454
63MP0003724_increased_susceptibility_to1.35546354
64MP0000747_muscle_weakness1.35230937
65MP0003172_abnormal_lysosome_physiology1.33490822
66MP0000490_abnormal_crypts_of1.33391723
67MP0001873_stomach_inflammation1.30453573
68MP0005257_abnormal_intraocular_pressure1.29170279
69MP0003448_altered_tumor_morphology1.28641485
70MP0005390_skeleton_phenotype1.28024944
71MP0000681_abnormal_thyroid_gland1.27138841
72MP0000716_abnormal_immune_system1.25984999
73MP0001986_abnormal_taste_sensitivity1.24073168
74MP0002429_abnormal_blood_cell1.19004857
75MP0004185_abnormal_adipocyte_glucose1.18311927
76MP0001853_heart_inflammation1.18304767
77MP0005666_abnormal_adipose_tissue1.18008754
78MP0003303_peritoneal_inflammation1.17878462
79MP0001663_abnormal_digestive_system1.17779194
80MP0008874_decreased_physiological_sensi1.15429897
81MP0000604_amyloidosis1.15071172
82MP0002998_abnormal_bone_remodeling1.14597050
83MP0002332_abnormal_exercise_endurance1.14480735
84MP0001845_abnormal_inflammatory_respons1.14372019
85MP0005397_hematopoietic_system_phenotyp1.13249985
86MP0001545_abnormal_hematopoietic_system1.13249985
87MP0008004_abnormal_stomach_pH1.12527927
88MP0005423_abnormal_somatic_nervous1.12307908
89MP0000372_irregular_coat_pigmentation1.11169813
90MP0002733_abnormal_thermal_nociception1.10120310
91MP0002106_abnormal_muscle_physiology1.09024691
92MP0004087_abnormal_muscle_fiber1.08319455
93MP0004947_skin_inflammation1.08051223
94MP0003183_abnormal_peptide_metabolism1.06919590
95MP0005275_abnormal_skin_tensile1.06914714
96MP0003646_muscle_fatigue1.06503360
97MP0000767_abnormal_smooth_muscle1.06290183
98MP0005166_decreased_susceptibility_to1.03771547
99MP0002282_abnormal_trachea_morphology1.03769413
100MP0003091_abnormal_cell_migration1.02673669
101MP0003763_abnormal_thymus_physiology1.02609736
102MP0002736_abnormal_nociception_after1.00767619
103MP0001542_abnormal_bone_strength1.00002939
104MP0005375_adipose_tissue_phenotype0.99488918
105MP0002722_abnormal_immune_system0.98702392
106MP0000689_abnormal_spleen_morphology0.98497105
107MP0004883_abnormal_blood_vessel0.98149540
108MP0004036_abnormal_muscle_relaxation0.96892805
109MP0001968_abnormal_touch/_nociception0.96540526
110MP0005409_darkened_coat_color0.95342661
111MP0004233_abnormal_muscle_weight0.95139423
112MP0000678_abnormal_parathyroid_gland0.94350704
113MP0003787_abnormal_imprinting0.93354283
114MP0000733_abnormal_muscle_development0.92892954
115MP0001849_ear_inflammation0.91909924
116MP0008789_abnormal_olfactory_epithelium0.91816162
117MP0005381_digestive/alimentary_phenotyp0.91300216
118MP0003866_abnormal_defecation0.88738930
119MP0010155_abnormal_intestine_physiology0.88543211
120MP0004808_abnormal_hematopoietic_stem0.87241168
121MP0005394_taste/olfaction_phenotype0.87008971
122MP0005499_abnormal_olfactory_system0.87008971
123MP0008995_early_reproductive_senescence0.86013505
124MP0003566_abnormal_cell_adhesion0.83816095
125MP0009764_decreased_sensitivity_to0.83684564
126MP0001727_abnormal_embryo_implantation0.82821603
127MP0000538_abnormal_urinary_bladder0.82366270
128MP0003453_abnormal_keratinocyte_physiol0.81465703
129MP0003186_abnormal_redox_activity0.81419697
130MP0005369_muscle_phenotype0.81000434
131MP0003828_pulmonary_edema0.80184637
132MP0000049_abnormal_middle_ear0.79765478
133MP0000703_abnormal_thymus_morphology0.79414059
134MP0002938_white_spotting0.79289857
135MP0002102_abnormal_ear_morphology0.78988454
136MP0003942_abnormal_urinary_system0.78302938
137MP0002653_abnormal_ependyma_morphology0.77931765
138MP0005023_abnormal_wound_healing0.77759670
139MP0010386_abnormal_urinary_bladder0.76899986
140MP0003795_abnormal_bone_structure0.76516068
141MP0002396_abnormal_hematopoietic_system0.75506123
142MP0002089_abnormal_postnatal_growth/wei0.74935376
143MP0002113_abnormal_skeleton_development0.74797746
144MP0005083_abnormal_biliary_tract0.74750465
145MP0008469_abnormal_protein_level0.74637456
146MP0001970_abnormal_pain_threshold0.73715975
147MP0008569_lethality_at_weaning0.72677794
148MP0005508_abnormal_skeleton_morphology0.72381110
149MP0003705_abnormal_hypodermis_morpholog0.71705995

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.45606144
2Exercise-induced myalgia (HP:0003738)4.24515856
3Eczematoid dermatitis (HP:0000976)4.22752943
4Elevated erythrocyte sedimentation rate (HP:0003565)4.21777359
5Myositis (HP:0100614)3.99629657
6Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.90003503
7Type 1 muscle fiber predominance (HP:0003803)3.77557528
8Recurrent bacterial skin infections (HP:0005406)3.67293150
9Vacuolated lymphocytes (HP:0001922)3.63947146
10Myopathic facies (HP:0002058)3.62661313
11Muscle fiber inclusion bodies (HP:0100299)3.62027320
12Distal lower limb muscle weakness (HP:0009053)3.60572677
13Nemaline bodies (HP:0003798)3.56828079
14Orchitis (HP:0100796)3.50924370
15Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.49192511
16Abnormality of macrophages (HP:0004311)3.29057360
17Vertebral compression fractures (HP:0002953)3.24187929
18Systemic lupus erythematosus (HP:0002725)3.20284563
19Centrally nucleated skeletal muscle fibers (HP:0003687)3.16734304
20Abnormality of skeletal muscle fiber size (HP:0012084)3.01886983
21Asymmetric septal hypertrophy (HP:0001670)3.01708152
22Retrobulbar optic neuritis (HP:0100654)2.87682989
23Optic neuritis (HP:0100653)2.87682989
24Increased variability in muscle fiber diameter (HP:0003557)2.87066839
25Obstructive lung disease (HP:0006536)2.85297501
26Chronic obstructive pulmonary disease (HP:0006510)2.85297501
27Protrusio acetabuli (HP:0003179)2.82591791
28Ulnar deviation of the wrist (HP:0003049)2.81698426
29Purpura (HP:0000979)2.79781520
30Bulbar palsy (HP:0001283)2.76932432
31Difficulty running (HP:0009046)2.73456485
32Failure to thrive in infancy (HP:0001531)2.72890619
33Muscle stiffness (HP:0003552)2.68273675
34Increased connective tissue (HP:0009025)2.67729643
35Recurrent gram-negative bacterial infections (HP:0005420)2.64821852
36Peritonitis (HP:0002586)2.64722946
37Hyporeflexia of lower limbs (HP:0002600)2.57021698
38Muscle fiber splitting (HP:0003555)2.55725511
39Gingivitis (HP:0000230)2.52635036
40Ulnar claw (HP:0001178)2.47804516
41Wrist flexion contracture (HP:0001239)2.47442042
42Petechiae (HP:0000967)2.46248953
43Glomerulonephritis (HP:0000099)2.44893494
44Easy fatigability (HP:0003388)2.43370698
45Achilles tendon contracture (HP:0001771)2.42078403
46Obstructive sleep apnea (HP:0002870)2.39604755
47Prolonged bleeding time (HP:0003010)2.39496973
48Increased IgM level (HP:0003496)2.37465137
49Distal lower limb amyotrophy (HP:0008944)2.36836885
50Abnormality of the anterior horn cell (HP:0006802)2.34149650
51Degeneration of anterior horn cells (HP:0002398)2.34149650
52Dysostosis multiplex (HP:0000943)2.33180212
53Mediastinal lymphadenopathy (HP:0100721)2.32736868
54Round ear (HP:0100830)2.32503584
55Abnormality of dentin (HP:0010299)2.30874441
56Hyperthyroidism (HP:0000836)2.30015163
57Increased serum ferritin (HP:0003281)2.27810125
58Rhabdomyolysis (HP:0003201)2.25026228
59Nasal polyposis (HP:0100582)2.24197390
60Supranuclear gaze palsy (HP:0000605)2.22379566
61Muscle hypertrophy of the lower extremities (HP:0008968)2.21511863
62Cellulitis (HP:0100658)2.21446272
63Axonal loss (HP:0003447)2.21025367
64Albinism (HP:0001022)2.20481747
65J-shaped sella turcica (HP:0002680)2.19496820
66Thin bony cortex (HP:0002753)2.18721646
67Distal arthrogryposis (HP:0005684)2.18391810
68Neck muscle weakness (HP:0000467)2.17534979
69Recurrent skin infections (HP:0001581)2.17053873
70Increased IgE level (HP:0003212)2.16088416
71Hypochromic anemia (HP:0001931)2.16043101
72Slender build (HP:0001533)2.15560331
73Visual hallucinations (HP:0002367)2.15303012
74Abnormality of glycolipid metabolism (HP:0010969)2.14972599
75Abnormality of liposaccharide metabolism (HP:0010968)2.14972599
76Abnormality of glycosphingolipid metabolism (HP:0004343)2.14972599
77Abnormality of the nasal mucosa (HP:0000433)2.13190421
78Hypertensive crisis (HP:0100735)2.11989840
79Myotonia (HP:0002486)2.10764461
80Abnormality of the Achilles tendon (HP:0005109)2.09574163
81Mesangial abnormality (HP:0001966)2.09192353
82Waddling gait (HP:0002515)2.08637583
83EMG: myopathic abnormalities (HP:0003458)2.06193005
84Premature rupture of membranes (HP:0001788)2.03716878
85Beaking of vertebral bodies (HP:0004568)2.03209210
86Ankle clonus (HP:0011448)2.02163242
87Vasculitis (HP:0002633)1.99775450
88Increased cerebral lipofuscin (HP:0011813)1.98960819
89Cervical subluxation (HP:0003308)1.97591343
90Flexion contracture of toe (HP:0005830)1.97259981
91Joint contractures involving the joints of the feet (HP:0100492)1.97259981
92Mildly elevated creatine phosphokinase (HP:0008180)1.95323188
93Hypothermia (HP:0002045)1.94578034
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93695337
95Difficulty climbing stairs (HP:0003551)1.93493222
96Hypercortisolism (HP:0001578)1.93119846
97Stomatitis (HP:0010280)1.92352424
98Deformed sella turcica (HP:0002681)1.91740088
99Segmental peripheral demyelination/remyelination (HP:0003481)1.91519071
100Heterochromia iridis (HP:0001100)1.91231589
101Camptodactyly of toe (HP:0001836)1.90727815
102Diminished motivation (HP:0000745)1.88592323
103Foot dorsiflexor weakness (HP:0009027)1.87833936
104Myokymia (HP:0002411)1.87409181
105Spontaneous hematomas (HP:0007420)1.86951277
106Spinal rigidity (HP:0003306)1.86684778
107Abnormality of cells of the erythroid lineage (HP:0012130)1.86385806
108Increased density of long bones (HP:0006392)1.86381692
109Glomerulopathy (HP:0100820)1.85737119
110Gastrointestinal infarctions (HP:0005244)1.85606773
111Poor head control (HP:0002421)1.85213389
112Hepatosplenomegaly (HP:0001433)1.84238472
113Joint stiffness (HP:0001387)1.82727646
114Meningitis (HP:0001287)1.82318934
115Disinhibition (HP:0000734)1.81983610
116Recurrent fungal infections (HP:0002841)1.81702369
117Urticaria (HP:0001025)1.80979275
118EMG: neuropathic changes (HP:0003445)1.80744486
119Reticulocytopenia (HP:0001896)1.80129911
120Large eyes (HP:0001090)1.79917944
121Hypergammaglobulinemia (HP:0010702)1.79408821
122Lissencephaly (HP:0001339)1.79253791
123Hyperparathyroidism (HP:0000843)1.79208584
124Cerebral aneurysm (HP:0004944)1.78572084
125Growth hormone excess (HP:0000845)1.78556566
126Interstitial pulmonary disease (HP:0006530)1.78461424
127Acrocyanosis (HP:0001063)1.77213589
128Facial edema (HP:0000282)1.76658714
129Bladder diverticulum (HP:0000015)1.76409890
130Abnormality of mucopolysaccharide metabolism (HP:0011020)1.76363660
131Abnormality of polysaccharide metabolism (HP:0011012)1.76363660
132Abnormality of glycosaminoglycan metabolism (HP:0004371)1.76363660
133Epistaxis (HP:0000421)1.76009223
134Aortic dissection (HP:0002647)1.74750856
135Basal ganglia calcification (HP:0002135)1.74666201
136Periorbital edema (HP:0100539)1.74611340
137Gowers sign (HP:0003391)1.74156364
138Abnormality of iron homeostasis (HP:0011031)1.73837723
139Stridor (HP:0010307)1.73485868
140Abnormal number of erythroid precursors (HP:0012131)1.73462260
141Adducted thumb (HP:0001181)1.72919595
142Mitral regurgitation (HP:0001653)1.72126693
143Abnormality of the pericardium (HP:0001697)1.72068645
144Increased neuronal autofluorescent lipopigment (HP:0002074)1.71800639
145Abnormality of the aortic arch (HP:0012303)1.71213313
146Hyperacusis (HP:0010780)1.70636623
147Ragged-red muscle fibers (HP:0003200)1.70506673
148Pulmonary infiltrates (HP:0002113)1.69801936
149Abnormality of the lumbar spine (HP:0100712)1.69610385
150Soft skin (HP:0000977)1.69495346
151Calf muscle hypertrophy (HP:0008981)1.69153155
152Long palpebral fissure (HP:0000637)1.69020942
153Shallow orbits (HP:0000586)1.68559218
154Palpebral edema (HP:0100540)1.67918376
155Abnormality of the foot musculature (HP:0001436)1.67826446
156Bicuspid aortic valve (HP:0001647)1.67813115
157Pathologic fracture (HP:0002756)1.67666355
158Xerostomia (HP:0000217)1.67483414
159Spinal canal stenosis (HP:0003416)1.67376032
160Ankle contracture (HP:0006466)1.66850038
161Hemoptysis (HP:0002105)1.65889806
162Mucopolysacchariduria (HP:0008155)1.65731805
163Urinary glycosaminoglycan excretion (HP:0003541)1.65731805
164Abnormal delayed hypersensitivity skin test (HP:0002963)1.65421204
165Spondylolisthesis (HP:0003302)1.64804555
166Thoracic kyphosis (HP:0002942)1.64776194

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LIMK13.47636319
2SIK33.23053084
3TESK13.09776887
4BLK3.07547896
5PIM22.95639701
6ERN12.91198451
7TESK22.73899674
8NME22.65731586
9TRIB32.43785156
10SIK12.37198634
11TBK12.20436867
12PRPF4B2.13370212
13MAP3K121.99403997
14MAP3K101.88272496
15TAOK11.82211222
16IRAK41.81347914
17MAPKAPK31.80479047
18TNK21.78732679
19DYRK31.74902006
20DYRK21.72638319
21RIPK41.70188764
22IRAK31.69601651
23PRKD21.68784455
24MARK21.58704644
25EPHA31.55879388
26EPHB21.55622092
27MAP3K111.53929374
28MAP4K11.53440243
29ZAP701.51673264
30ICK1.51149364
31IRAK11.50954307
32KIT1.43243145
33DYRK1B1.41708884
34ILK1.37880493
35RPS6KA21.34310928
36SIK21.32251476
37SMG11.30690776
38MAP3K131.29190937
39RPS6KA41.27790169
40BTK1.25725577
41LRRK21.25407130
42PRKD31.23442389
43MAP2K31.23059612
44GRK61.22765780
45OBSCN1.22338128
46MAP3K11.22072912
47STK161.21611815
48FES1.20304803
49MAPK121.18651027
50KDR1.17892194
51MATK1.14746969
52PAK41.10504903
53ARAF1.10068510
54FGFR41.09050953
55CSK1.08260233
56CLK11.07971412
57EIF2AK11.07651700
58RPS6KA61.07152269
59RIPK11.06985874
60IKBKE1.02112187
61CDK191.01624861
62EPHB11.00092467
63TAOK20.99803620
64ERBB30.98204655
65IRAK20.97370797
66RPS6KL10.96555564
67RPS6KC10.96555564
68BUB10.95478365
69CAMKK10.93113144
70MAP2K20.92554862
71UHMK10.91429575
72TXK0.91268314
73PHKG20.90826387
74PHKG10.90826387
75MAP3K60.90226657
76MYLK0.90186437
77SCYL20.88290989
78HIPK20.88195903
79PDPK10.87985527
80MAP3K70.86740979
81SYK0.85065718
82INSRR0.82432598
83MAPKAPK20.82028938
84MAP2K40.80121986
85YES10.79316414
86STK380.77548633
87MAP3K140.77544182
88MOS0.77448236
89FGFR30.76965483
90CDC42BPA0.75466976
91DMPK0.73626462
92TYK20.71987827
93PIK3CG0.71835318
94PAK60.71120314
95ACVR1B0.70501047
96JAK30.69853955
97MARK30.68865408
98TYRO30.68520571
99TGFBR20.68471635
100TEC0.67981724
101MUSK0.67736301
102IKBKB0.66297483
103CSF1R0.65765659
104MINK10.65608953
105LYN0.65257400
106PDK10.63484504
107PTK60.62312532
108CAMKK20.61078233
109PAK10.59890119
110TTN0.59818113
111HCK0.59631308
112ITK0.58765225
113MAPK130.58458122
114KSR20.57420453
115PRKD10.57364802
116PKN20.57086574
117PTK20.56008549
118DAPK30.54583802
119ABL20.51056404
120BRAF0.50983282
121BCKDK0.50284232
122PIM10.50173664
123TRPM70.49411999
124MAPK40.48815897
125BCR0.48025997
126BMX0.47713457
127ROCK20.47605022
128ROCK10.47499536
129PRKCD0.47270393
130LCK0.46352759
131NTRK10.45660951
132RET0.44662199
133ADRBK20.44382737
134MAP3K30.44239608
135STK110.44172048
136CDK140.44055358
137EEF2K0.44035157
138EPHA20.44029451
139CHUK0.43255451
140MARK10.43113610
141TGFBR10.43033186
142FYN0.42858775
143STK100.42588684
144CAMK10.42020268
145MAP2K10.41417691
146NEK90.40725921
147RPS6KA50.39441965
148CDK80.38956360
149DDR20.38449286
150LMTK20.38428615
151CDK180.38231554
152AURKA0.37053029
153PRKG20.35693505

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.61131319
2Leishmaniasis_Homo sapiens_hsa051402.34130229
3Shigellosis_Homo sapiens_hsa051312.27813465
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.11698741
5Proteasome_Homo sapiens_hsa030502.06352596
6Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.98492291
7Ribosome_Homo sapiens_hsa030101.92074033
8Phagosome_Homo sapiens_hsa041451.81977783
9Pertussis_Homo sapiens_hsa051331.77685834
10Other glycan degradation_Homo sapiens_hsa005111.74897817
11Lysosome_Homo sapiens_hsa041421.74301999
12Salmonella infection_Homo sapiens_hsa051321.73764917
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.70450694
14Pentose phosphate pathway_Homo sapiens_hsa000301.69972583
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.59225028
16Apoptosis_Homo sapiens_hsa042101.55286691
17Osteoclast differentiation_Homo sapiens_hsa043801.54829012
18Viral myocarditis_Homo sapiens_hsa054161.53855681
19Legionellosis_Homo sapiens_hsa051341.42523686
20Tuberculosis_Homo sapiens_hsa051521.41216960
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39302436
22Base excision repair_Homo sapiens_hsa034101.38028347
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38002477
24Chronic myeloid leukemia_Homo sapiens_hsa052201.36944521
25Malaria_Homo sapiens_hsa051441.36668126
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36519274
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34496749
28Measles_Homo sapiens_hsa051621.33745200
29Non-small cell lung cancer_Homo sapiens_hsa052231.33044215
30Toxoplasmosis_Homo sapiens_hsa051451.33019227
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.31262740
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28865901
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25064110
34B cell receptor signaling pathway_Homo sapiens_hsa046621.20177112
35Antigen processing and presentation_Homo sapiens_hsa046121.19823764
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18927978
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17689534
38Synaptic vesicle cycle_Homo sapiens_hsa047211.15558804
39DNA replication_Homo sapiens_hsa030301.15125290
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.12816565
41Epstein-Barr virus infection_Homo sapiens_hsa051691.12630620
42Insulin signaling pathway_Homo sapiens_hsa049101.12092090
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11056932
44Hepatitis B_Homo sapiens_hsa051611.08492086
45Notch signaling pathway_Homo sapiens_hsa043301.08348311
46Staphylococcus aureus infection_Homo sapiens_hsa051501.06841666
47Influenza A_Homo sapiens_hsa051641.05640642
48Acute myeloid leukemia_Homo sapiens_hsa052211.05522537
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.05200749
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.04473677
51Dilated cardiomyopathy_Homo sapiens_hsa054141.03571464
52Pancreatic cancer_Homo sapiens_hsa052121.03151248
53VEGF signaling pathway_Homo sapiens_hsa043701.02822585
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02778513
55Hematopoietic cell lineage_Homo sapiens_hsa046401.02473449
56Rheumatoid arthritis_Homo sapiens_hsa053231.01378918
57T cell receptor signaling pathway_Homo sapiens_hsa046601.00555486
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99191586
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.98116193
60Endocytosis_Homo sapiens_hsa041440.97630253
61GnRH signaling pathway_Homo sapiens_hsa049120.95978571
62Colorectal cancer_Homo sapiens_hsa052100.95862488
63Renal cell carcinoma_Homo sapiens_hsa052110.94984229
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.93686145
65TNF signaling pathway_Homo sapiens_hsa046680.92753395
66N-Glycan biosynthesis_Homo sapiens_hsa005100.92172852
67African trypanosomiasis_Homo sapiens_hsa051430.90892120
68MAPK signaling pathway_Homo sapiens_hsa040100.88447312
69Parkinsons disease_Homo sapiens_hsa050120.87899604
70Herpes simplex infection_Homo sapiens_hsa051680.86918604
71Thyroid cancer_Homo sapiens_hsa052160.86906436
72ErbB signaling pathway_Homo sapiens_hsa040120.86509708
73Protein export_Homo sapiens_hsa030600.85920551
74Spliceosome_Homo sapiens_hsa030400.85533049
75Fructose and mannose metabolism_Homo sapiens_hsa000510.85198874
76Long-term potentiation_Homo sapiens_hsa047200.84334106
77Graft-versus-host disease_Homo sapiens_hsa053320.84028513
78Glioma_Homo sapiens_hsa052140.83925968
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83724094
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83514504
81mTOR signaling pathway_Homo sapiens_hsa041500.83072930
82Pyrimidine metabolism_Homo sapiens_hsa002400.81485001
83Prion diseases_Homo sapiens_hsa050200.79939863
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79905836
85Bladder cancer_Homo sapiens_hsa052190.79895298
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.79278375
87Oxytocin signaling pathway_Homo sapiens_hsa049210.79251595
88Chemokine signaling pathway_Homo sapiens_hsa040620.79227837
89Asthma_Homo sapiens_hsa053100.78236503
90Primary immunodeficiency_Homo sapiens_hsa053400.77339453
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76480405
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75387412
93Viral carcinogenesis_Homo sapiens_hsa052030.75178615
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73412733
95Allograft rejection_Homo sapiens_hsa053300.72438130
96Oxidative phosphorylation_Homo sapiens_hsa001900.72239594
97Autoimmune thyroid disease_Homo sapiens_hsa053200.70806900
98Rap1 signaling pathway_Homo sapiens_hsa040150.70658379
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70168529
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69704272
101RNA polymerase_Homo sapiens_hsa030200.69647678
102Platelet activation_Homo sapiens_hsa046110.69373931
103HTLV-I infection_Homo sapiens_hsa051660.68587762
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68042788
105Proteoglycans in cancer_Homo sapiens_hsa052050.67614374
106Cholinergic synapse_Homo sapiens_hsa047250.67203040
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.67083159
108Cell cycle_Homo sapiens_hsa041100.66525960
109AMPK signaling pathway_Homo sapiens_hsa041520.66302936
110Insulin resistance_Homo sapiens_hsa049310.65864623
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.65236142
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65182548
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.64158589
114Galactose metabolism_Homo sapiens_hsa000520.63625683
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.63613374
116Choline metabolism in cancer_Homo sapiens_hsa052310.63598555
117Sulfur relay system_Homo sapiens_hsa041220.63554448
118Focal adhesion_Homo sapiens_hsa045100.63239809
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63034531
120Huntingtons disease_Homo sapiens_hsa050160.61011883
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60682768
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60569958
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59744804
124Collecting duct acid secretion_Homo sapiens_hsa049660.58357763
125Cardiac muscle contraction_Homo sapiens_hsa042600.58265279
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57223281
127Endometrial cancer_Homo sapiens_hsa052130.57220008
128Estrogen signaling pathway_Homo sapiens_hsa049150.57015307
129Amoebiasis_Homo sapiens_hsa051460.56834539
130p53 signaling pathway_Homo sapiens_hsa041150.56518003
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55951567
132Vibrio cholerae infection_Homo sapiens_hsa051100.55864217
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55236724
134Axon guidance_Homo sapiens_hsa043600.54540226
135Pathways in cancer_Homo sapiens_hsa052000.53381965
136Prolactin signaling pathway_Homo sapiens_hsa049170.52944879
137Hepatitis C_Homo sapiens_hsa051600.52089316
138Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51471755
139Melanoma_Homo sapiens_hsa052180.49489113
140Small cell lung cancer_Homo sapiens_hsa052220.49044798

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