FAM8A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.89579486
2detection of molecule of bacterial origin (GO:0032490)4.85952737
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.80621402
4negative regulation of cell killing (GO:0031342)4.80621402
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.26829252
6L-phenylalanine catabolic process (GO:0006559)4.26829252
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.17071115
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.17071115
9modulation by symbiont of host immune response (GO:0052553)4.17071115
10positive regulation by symbiont of host defense response (GO:0052509)4.17071115
11modulation by symbiont of host defense response (GO:0052031)4.17071115
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.17071115
13detection of external biotic stimulus (GO:0098581)4.05881780
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.01948159
15L-phenylalanine metabolic process (GO:0006558)4.01948159
16detection of other organism (GO:0098543)4.00608679
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.89680891
18positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.85267692
19alpha-linolenic acid metabolic process (GO:0036109)3.83923507
20negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.82846718
21leukocyte migration involved in inflammatory response (GO:0002523)3.82617836
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.73119596
23antigen processing and presentation of endogenous antigen (GO:0019883)3.58910220
24aromatic amino acid family catabolic process (GO:0009074)3.58018241
25detection of bacterium (GO:0016045)3.56405243
26positive regulation of gamma-delta T cell activation (GO:0046645)3.52497592
27cysteine metabolic process (GO:0006534)3.52357761
28lysine catabolic process (GO:0006554)3.51926163
29lysine metabolic process (GO:0006553)3.51926163
30negative regulation of protein activation cascade (GO:2000258)3.51498367
31negative regulation of lymphocyte mediated immunity (GO:0002707)3.51012769
32urea metabolic process (GO:0019627)3.49851633
33urea cycle (GO:0000050)3.49851633
34glutamate metabolic process (GO:0006536)3.46630368
35macrophage activation involved in immune response (GO:0002281)3.45491391
36response to interleukin-15 (GO:0070672)3.44522697
37detection of biotic stimulus (GO:0009595)3.44164250
38antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.42497458
39regulation of short-term neuronal synaptic plasticity (GO:0048172)3.41260143
40negative regulation of complement activation (GO:0045916)3.38185260
41negative regulation of B cell mediated immunity (GO:0002713)3.34041586
42negative regulation of immunoglobulin mediated immune response (GO:0002890)3.34041586
43dicarboxylic acid biosynthetic process (GO:0043650)3.33764073
44neutrophil activation involved in immune response (GO:0002283)3.31541018
45cellular extravasation (GO:0045123)3.31414047
46bile acid biosynthetic process (GO:0006699)3.31020038
47negative regulation of fibrinolysis (GO:0051918)3.29821420
48drug catabolic process (GO:0042737)3.26520731
49sulfur amino acid catabolic process (GO:0000098)3.25599728
50glyoxylate metabolic process (GO:0046487)3.21338825
51kynurenine metabolic process (GO:0070189)3.20723948
52positive regulation of cellular amide metabolic process (GO:0034250)3.20286047
53negative regulation of humoral immune response (GO:0002921)3.19359056
54positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.19022897
55locomotory exploration behavior (GO:0035641)3.16799704
56nitrogen cycle metabolic process (GO:0071941)3.14796538
57cellular ketone body metabolic process (GO:0046950)3.13288426
58negative regulation of erythrocyte differentiation (GO:0045647)3.06005526
59high-density lipoprotein particle remodeling (GO:0034375)3.05981335
60layer formation in cerebral cortex (GO:0021819)3.05378632
61synaptic vesicle maturation (GO:0016188)3.04519830
62negative regulation of type 2 immune response (GO:0002829)3.03811179
63protein carboxylation (GO:0018214)3.01347787
64peptidyl-glutamic acid carboxylation (GO:0017187)3.01347787
65nucleobase catabolic process (GO:0046113)2.98700514
66regulation of fibrinolysis (GO:0051917)2.98402981
67indole-containing compound catabolic process (GO:0042436)2.98279193
68indolalkylamine catabolic process (GO:0046218)2.98279193
69tryptophan catabolic process (GO:0006569)2.98279193
70microglial cell activation (GO:0001774)2.98029806
71glutamate secretion (GO:0014047)2.97441661
72response to host immune response (GO:0052572)2.97291175
73response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.97291175
74complement activation, alternative pathway (GO:0006957)2.95860447
75regulation of cholesterol homeostasis (GO:2000188)2.93234144
76regulation of beta-amyloid formation (GO:1902003)2.92564087
77homocysteine metabolic process (GO:0050667)2.91782475
78regulation of protein activation cascade (GO:2000257)2.91481114
79pyrimidine nucleobase catabolic process (GO:0006208)2.91129129
80regulation of interferon-beta biosynthetic process (GO:0045357)2.91087663
81regulation of B cell receptor signaling pathway (GO:0050855)2.89863708
82neutrophil mediated immunity (GO:0002446)2.87973726
83bile acid metabolic process (GO:0008206)2.87199080
84positive regulation of fatty acid beta-oxidation (GO:0032000)2.86400932
85regulation of cellular amide metabolic process (GO:0034248)2.86152707
86regulation of triglyceride catabolic process (GO:0010896)2.85452293
87serine family amino acid catabolic process (GO:0009071)2.83487803
88regulation of T-helper 2 cell differentiation (GO:0045628)2.83295514
89negative regulation of leukocyte mediated immunity (GO:0002704)2.83241358
90cellular modified amino acid catabolic process (GO:0042219)2.81350784
91macrophage activation (GO:0042116)2.80483630
92tryptophan metabolic process (GO:0006568)2.79001238
93exogenous drug catabolic process (GO:0042738)2.78358077
94response to host (GO:0075136)2.76956309
95response to host defenses (GO:0052200)2.76956309
96response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.76956309
97reverse cholesterol transport (GO:0043691)2.76256757
98negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.76052653
99response to peptidoglycan (GO:0032494)2.75379391
100regulation of fatty acid beta-oxidation (GO:0031998)2.74589054
101regulation of complement activation (GO:0030449)2.74242972
102triglyceride homeostasis (GO:0070328)2.73979483
103acylglycerol homeostasis (GO:0055090)2.73979483
104tyrosine metabolic process (GO:0006570)2.73764461
105vocalization behavior (GO:0071625)2.73465599
106positive regulation of lipid catabolic process (GO:0050996)2.73292708
107negative regulation of cholesterol transport (GO:0032375)2.73140258
108negative regulation of sterol transport (GO:0032372)2.73140258
109proline transport (GO:0015824)2.72149010
110regulation of amyloid precursor protein catabolic process (GO:1902991)2.72125294
111fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.71846958
112epoxygenase P450 pathway (GO:0019373)2.71106844
113ketone body metabolic process (GO:1902224)2.69307913
114neutrophil activation (GO:0042119)2.68475374
115regulation of ARF protein signal transduction (GO:0032012)2.66552476
116regulation of gamma-delta T cell activation (GO:0046643)2.65525822
117cellular response to interleukin-15 (GO:0071350)2.65307815
118alpha-amino acid catabolic process (GO:1901606)2.62700732
119coenzyme catabolic process (GO:0009109)2.62451625
120flavonoid metabolic process (GO:0009812)2.61011353
121aromatic amino acid family metabolic process (GO:0009072)2.60221072
122neurotransmitter secretion (GO:0007269)2.59442745
123regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.59143943
124short-chain fatty acid metabolic process (GO:0046459)2.58480581
125positive regulation of fatty acid oxidation (GO:0046321)2.56362695
126activation of protein kinase A activity (GO:0034199)2.56292535
127myeloid leukocyte mediated immunity (GO:0002444)2.55902825
128drug transmembrane transport (GO:0006855)2.55550338
129protein-lipid complex remodeling (GO:0034368)2.55220107
130macromolecular complex remodeling (GO:0034367)2.55220107
131plasma lipoprotein particle remodeling (GO:0034369)2.55220107
132cellular amino acid catabolic process (GO:0009063)2.55180936
133positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.54257929
134aspartate family amino acid catabolic process (GO:0009068)2.53452914
135amino-acid betaine metabolic process (GO:0006577)2.53065567
136bile acid and bile salt transport (GO:0015721)2.52906151
137production of molecular mediator involved in inflammatory response (GO:0002532)2.52847813
138alanine transport (GO:0032328)2.52704592
139killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.51326608
140disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.51326608
1412-oxoglutarate metabolic process (GO:0006103)2.49390947
142phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.48196010
143acetyl-CoA metabolic process (GO:0006084)2.47793278
144regulation of bile acid biosynthetic process (GO:0070857)2.47736346
145fatty acid transmembrane transport (GO:1902001)2.47640454
146regulation of gamma-delta T cell differentiation (GO:0045586)2.47347432
147positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.46706634
148dicarboxylic acid catabolic process (GO:0043649)2.46450556
149exploration behavior (GO:0035640)2.45785200
150alkaloid metabolic process (GO:0009820)2.44931468
151gamma-aminobutyric acid transport (GO:0015812)2.42963183
152cellular glucuronidation (GO:0052695)2.42024605
153regulation of clathrin-mediated endocytosis (GO:2000369)2.41648230
154leukocyte aggregation (GO:0070486)2.41194967
155cholesterol efflux (GO:0033344)2.40671033
156negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.40603910
157negative regulation of T-helper cell differentiation (GO:0045623)2.40603910
158synaptic vesicle docking involved in exocytosis (GO:0016081)2.39865430
159regulation of glutamate receptor signaling pathway (GO:1900449)2.38139701
160negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.37348587
161regulation of humoral immune response (GO:0002920)2.37124418
162indolalkylamine metabolic process (GO:0006586)2.36527527
163regulation of myeloid leukocyte mediated immunity (GO:0002886)2.35652926
164antigen processing and presentation via MHC class Ib (GO:0002475)2.35509354
165synaptic vesicle exocytosis (GO:0016079)2.34939271
166midgut development (GO:0007494)2.34613448
167plasma lipoprotein particle clearance (GO:0034381)2.34433966
168positive regulation of insulin receptor signaling pathway (GO:0046628)2.34308187
169negative regulation of lipase activity (GO:0060192)2.34135582
170cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.33268408
171regulation of synaptic vesicle exocytosis (GO:2000300)2.33139808
172granulocyte activation (GO:0036230)2.32857882
173negative regulation of toll-like receptor signaling pathway (GO:0034122)2.30910937
174respiratory burst (GO:0045730)2.29747955
175hypotonic response (GO:0006971)2.28185070
176germinal center formation (GO:0002467)2.26801496
177plasma lipoprotein particle assembly (GO:0034377)2.24046841
178I-kappaB phosphorylation (GO:0007252)2.22896266
179regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.21267665
180very-low-density lipoprotein particle assembly (GO:0034379)2.20971688
181iron ion import (GO:0097286)2.20385393
182B cell receptor signaling pathway (GO:0050853)2.19944549
183regulation of leukocyte degranulation (GO:0043300)2.19686962
184cellular response to type I interferon (GO:0071357)2.19456004
185type I interferon signaling pathway (GO:0060337)2.19456004
186activated T cell proliferation (GO:0050798)2.18696752
187response to type I interferon (GO:0034340)2.18688846
188regulation of macrophage cytokine production (GO:0010935)2.18587222
189negative regulation of interleukin-12 production (GO:0032695)2.18375881
190regulation of necroptotic process (GO:0060544)2.18020950
191JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.17952269
192regulation of mast cell degranulation (GO:0043304)2.16784002
193positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.16304715

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.25493096
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.22814299
3EZH2_22144423_ChIP-Seq_EOC_Human2.91366420
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.87375079
5LXR_22158963_ChIP-Seq_LIVER_Mouse2.74069052
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.54717506
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.45535237
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.36684905
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.26845127
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13482155
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.08039290
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.00097368
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.98313604
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.96110198
15IRF8_27001747_Chip-Seq_BMDM_Mouse1.94328702
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94134314
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.93576102
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.92423608
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91014538
20RUNX_20019798_ChIP-Seq_JUKART_Human1.90607930
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.85947016
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82371348
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.82024846
24GBX2_23144817_ChIP-Seq_PC3_Human1.79892056
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78947265
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77686717
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77686717
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.77031469
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.74241320
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73845343
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67219065
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62368753
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.60119232
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60019166
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59992846
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58491759
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58093851
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54517872
39SPI1_23127762_ChIP-Seq_K562_Human1.53596474
40DROSHA_22980978_ChIP-Seq_HELA_Human1.51503910
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51501852
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51360425
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.51182586
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49786421
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48710195
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47196546
47REST_21632747_ChIP-Seq_MESCs_Mouse1.42714261
48VDR_24787735_ChIP-Seq_THP-1_Human1.40476007
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40367070
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37193942
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.36670558
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35346581
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35221594
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.34506950
55FOXA2_19822575_ChIP-Seq_HepG2_Human1.34495458
56ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33021978
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.32935440
58ZNF274_21170338_ChIP-Seq_K562_Hela1.32753632
59TCF7_22412390_ChIP-Seq_EML_Mouse1.31811930
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.30881722
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30268246
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28409591
63EZH2_27304074_Chip-Seq_ESCs_Mouse1.28173961
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.27432452
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.26061041
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25263680
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.25261948
68CLOCK_20551151_ChIP-Seq_293T_Human1.25215081
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.25027490
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.24821689
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.23814926
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23476183
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21802075
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21348918
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20876751
76SMAD4_21799915_ChIP-Seq_A2780_Human1.19816022
77* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19016104
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18956279
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17842064
80AR_21572438_ChIP-Seq_LNCaP_Human1.17716700
81VDR_24763502_ChIP-Seq_THP-1_Human1.17481956
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.17093105
83REST_18959480_ChIP-ChIP_MESCs_Mouse1.15910980
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15785199
85EP300_21415370_ChIP-Seq_HL-1_Mouse1.15611814
86BCAT_22108803_ChIP-Seq_LS180_Human1.14967905
87GATA1_22025678_ChIP-Seq_K562_Human1.14726912
88SCL_19346495_ChIP-Seq_HPC-7_Human1.14639012
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14445219
90GATA1_19941827_ChIP-Seq_MEL_Mouse1.14102832
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13897565
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13805693
93TCF4_18268006_ChIP-ChIP_LS174T_Human1.13653333
94WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12693629
95* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11590199
96GATA1_19941826_ChIP-Seq_K562_Human1.10457342
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09865993
98TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08403724
99BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07906647
100AR_19668381_ChIP-Seq_PC3_Human1.06901367
101KDM2B_26808549_Chip-Seq_JURKAT_Human1.06186483
102ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05317688
103KDM2B_26808549_Chip-Seq_DND41_Human1.04491638
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.03728514
105PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03477264
106GATA2_19941826_ChIP-Seq_K562_Human1.03461169
107RUNX1_22412390_ChIP-Seq_EML_Mouse1.03446012
108TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.03379318
109KDM2B_26808549_Chip-Seq_K562_Human1.02691884
110FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02608653
111SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01890108
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01389818
113AHR_22903824_ChIP-Seq_MCF-7_Human1.01267328
114SMAD4_21741376_ChIP-Seq_HESCs_Human1.01230543
115CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01083239
116CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00825664
117KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00235165
118AR_25329375_ChIP-Seq_VCAP_Human0.98781601
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98402561
120STAT3_23295773_ChIP-Seq_U87_Human0.98344102
121WT1_19549856_ChIP-ChIP_CCG9911_Human0.98228021
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97594671
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97594671
124RXR_22108803_ChIP-Seq_LS180_Human0.97064702
125DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97002681
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96139236
127TP53_16413492_ChIP-PET_HCT116_Human0.95159087
128ZNF263_19887448_ChIP-Seq_K562_Human0.94990219
129SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93449412
130ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93043487
131NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92610272
132EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91581378
133RING1B_27294783_Chip-Seq_ESCs_Mouse0.91476619
134PU_27001747_Chip-Seq_BMDM_Mouse0.91169740
135PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89414562
136GATA3_27048872_Chip-Seq_THYMUS_Human0.89198713
137E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88407433
138MAF_26560356_Chip-Seq_TH1_Human0.88384372
139TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88185076
140SMAD3_21741376_ChIP-Seq_EPCs_Human0.87805901
141TAF15_26573619_Chip-Seq_HEK293_Human0.87616792
142TP53_18474530_ChIP-ChIP_U2OS_Human0.87529060
143CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86963009
144TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86677952
145SMAD3_21741376_ChIP-Seq_HESCs_Human0.85862834
146ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85506049
147CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.85326558
148EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84880260
149GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84867004
150SMAD_19615063_ChIP-ChIP_OVARY_Human0.84744905
151CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84411677
152BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84287485
153SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84110092
154P300_19829295_ChIP-Seq_ESCs_Human0.83996689
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.83540080
156SPI1_23547873_ChIP-Seq_NB4_Human0.83211914
157MYB_26560356_Chip-Seq_TH2_Human0.82119843
158TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.81935222
159OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81593671
160MYB_26560356_Chip-Seq_TH1_Human0.80994138
161AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80919992
162POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80611667
163KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.76951091
164GATA1_19941827_ChIP-Seq_MEL86_Mouse0.75706358
165RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.75172328
166FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.74875850
167GATA2_22383799_ChIP-Seq_G1ME_Mouse0.74195191

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.58509634
2MP0005360_urolithiasis5.50457877
3MP0003724_increased_susceptibility_to5.20597603
4MP0005085_abnormal_gallbladder_physiolo4.10841904
5MP0005365_abnormal_bile_salt3.72954276
6MP0004859_abnormal_synaptic_plasticity3.58044632
7MP0008875_abnormal_xenobiotic_pharmacok3.22179643
8MP0003436_decreased_susceptibility_to2.98325096
9MP0003252_abnormal_bile_duct2.96965318
10MP0003303_peritoneal_inflammation2.96636809
11MP0002132_abnormal_respiratory_system2.65762340
12MP0003300_gastrointestinal_ulcer2.59548940
13MP0003705_abnormal_hypodermis_morpholog2.53715862
14MP0005451_abnormal_body_composition2.53630765
15MP0005409_darkened_coat_color2.51078904
16MP0010329_abnormal_lipoprotein_level2.47553098
17MP0009780_abnormal_chondrocyte_physiolo2.43329771
18MP0004883_abnormal_blood_vessel2.22059305
19MP0010234_abnormal_vibrissa_follicle2.20643061
20MP0008260_abnormal_autophagy2.07456329
21MP0004270_analgesia2.06111208
22MP0003635_abnormal_synaptic_transmissio2.02516418
23MP0002419_abnormal_innate_immunity1.99941127
24MP0001666_abnormal_nutrient_absorption1.97030770
25MP0002009_preneoplasia1.85300638
26MP0002822_catalepsy1.85290763
27MP0003183_abnormal_peptide_metabolism1.84090603
28MP0003828_pulmonary_edema1.79286405
29MP0005464_abnormal_platelet_physiology1.72819740
30MP0005332_abnormal_amino_acid1.72151816
31MP0005025_abnormal_response_to1.69374742
32MP0001835_abnormal_antigen_presentation1.68976957
33MP0005083_abnormal_biliary_tract1.67899508
34MP0002063_abnormal_learning/memory/cond1.66226820
35MP0005164_abnormal_response_to1.65368700
36MP0001533_abnormal_skeleton_physiology1.61022808
37MP0003329_amyloid_beta_deposits1.59138628
38MP0003172_abnormal_lysosome_physiology1.55513918
39MP0009785_altered_susceptibility_to1.54154748
40MP0002909_abnormal_adrenal_gland1.53504511
41MP0009745_abnormal_behavioral_response1.53124989
42MP0004130_abnormal_muscle_cell1.52133583
43MP0002118_abnormal_lipid_homeostasis1.50136026
44MP0001851_eye_inflammation1.50014464
45MP0003868_abnormal_feces_composition1.48284894
46MP0006082_CNS_inflammation1.45670446
47MP0003880_abnormal_central_pattern1.45166574
48MP0003866_abnormal_defecation1.43419015
49MP0002277_abnormal_respiratory_mucosa1.36323947
50MP0001800_abnormal_humoral_immune1.35822871
51MP0001958_emphysema1.32441962
52MP0002837_dystrophic_cardiac_calcinosis1.30641693
53MP0002064_seizures1.27735510
54MP0002572_abnormal_emotion/affect_behav1.27091223
55MP0004019_abnormal_vitamin_homeostasis1.26924806
56MP0002138_abnormal_hepatobiliary_system1.25668942
57MP0000920_abnormal_myelination1.24361558
58MP0004484_altered_response_of1.22674172
59MP0005000_abnormal_immune_tolerance1.21357639
60MP0003195_calcinosis1.20278336
61MP0000465_gastrointestinal_hemorrhage1.17850547
62MP0002723_abnormal_immune_serum1.17608181
63MP0004858_abnormal_nervous_system1.16477162
64MP0003656_abnormal_erythrocyte_physiolo1.16348909
65MP0005535_abnormal_body_temperature1.16274877
66MP0009840_abnormal_foam_cell1.13825053
67MP0005187_abnormal_penis_morphology1.13589847
68MP0001440_abnormal_grooming_behavior1.13458407
69MP0006276_abnormal_autonomic_nervous1.13328351
70MP0010155_abnormal_intestine_physiology1.12689427
71MP0001501_abnormal_sleep_pattern1.12494632
72MP0009046_muscle_twitch1.11506019
73MP0002420_abnormal_adaptive_immunity1.11010746
74MP0001790_abnormal_immune_system1.10032397
75MP0005387_immune_system_phenotype1.10032397
76MP0003075_altered_response_to1.08204226
77MP0001915_intracranial_hemorrhage1.07865605
78MP0000609_abnormal_liver_physiology1.07852141
79MP0010368_abnormal_lymphatic_system1.07839741
80MP0001819_abnormal_immune_cell1.07771699
81MP0008004_abnormal_stomach_pH1.07765434
82MP0001968_abnormal_touch/_nociception1.06937310
83MP0000013_abnormal_adipose_tissue1.06859348
84MP0002998_abnormal_bone_remodeling1.06039053
85MP0002396_abnormal_hematopoietic_system1.05918321
86MP0002166_altered_tumor_susceptibility1.05621479
87MP0000685_abnormal_immune_system1.05007966
88MP0003221_abnormal_cardiomyocyte_apopto1.04311462
89MP0002734_abnormal_mechanical_nocicepti1.04185970
90MP0001486_abnormal_startle_reflex1.02144448
91MP0004947_skin_inflammation1.01775957
92MP0000604_amyloidosis1.01773990
93MP0004381_abnormal_hair_follicle1.00441420
94MP0002405_respiratory_system_inflammati0.99465462
95MP0008961_abnormal_basal_metabolism0.98312299
96MP0006054_spinal_hemorrhage0.97018914
97MP0002133_abnormal_respiratory_system0.96980030
98MP0005388_respiratory_system_phenotype0.96980030
99MP0005248_abnormal_Harderian_gland0.96540054
100MP0002733_abnormal_thermal_nociception0.96206254
101MP0005584_abnormal_enzyme/coenzyme_acti0.96074522
102MP0003122_maternal_imprinting0.94579843
103MP0001845_abnormal_inflammatory_respons0.94388938
104MP0003191_abnormal_cellular_cholesterol0.93203167
105MP0005166_decreased_susceptibility_to0.93158288
106MP0004885_abnormal_endolymph0.93066426
107MP0003806_abnormal_nucleotide_metabolis0.92392943
108MP0005623_abnormal_meninges_morphology0.91518692
109MP0008469_abnormal_protein_level0.90276716
110MP0005167_abnormal_blood-brain_barrier0.89476605
111MP0005386_behavior/neurological_phenoty0.89270230
112MP0004924_abnormal_behavior0.89270230
113MP0003045_fibrosis0.89166338
114MP0002928_abnormal_bile_duct0.89099929
115MP0003632_abnormal_nervous_system0.88464127
116MP0005319_abnormal_enzyme/_coenzyme0.88177735
117MP0002971_abnormal_brown_adipose0.87428561
118MP0008569_lethality_at_weaning0.87281116
119MP0002078_abnormal_glucose_homeostasis0.87253883
120MP0002452_abnormal_antigen_presenting0.87069718
121MP0001188_hyperpigmentation0.86911532
122MP0004782_abnormal_surfactant_physiolog0.86368071
123MP0000751_myopathy0.85598401
124MP0000858_altered_metastatic_potential0.85487617
125MP0004043_abnormal_pH_regulation0.84572111
126MP0002272_abnormal_nervous_system0.83778872
127MP0005397_hematopoietic_system_phenotyp0.83413845
128MP0001545_abnormal_hematopoietic_system0.83413845
129MP0000778_abnormal_nervous_system0.82365911
130MP0000569_abnormal_digit_pigmentation0.81562534
131MP0003633_abnormal_nervous_system0.81543244
132MP0000249_abnormal_blood_vessel0.80286331
133MP0003091_abnormal_cell_migration0.79683069
134MP0009053_abnormal_anal_canal0.79627528
135MP0005666_abnormal_adipose_tissue0.79391378
136MP0004510_myositis0.79006731
137MP0001177_atelectasis0.78947847
138MP0004811_abnormal_neuron_physiology0.78497566
139MP0002557_abnormal_social/conspecific_i0.78100421
140MP0009764_decreased_sensitivity_to0.77045342
141MP0005448_abnormal_energy_balance0.75711963
142MP0003283_abnormal_digestive_organ0.75491061
143MP0000716_abnormal_immune_system0.75431240
144MP0000537_abnormal_urethra_morphology0.75307048
145MP0009115_abnormal_fat_cell0.74762183
146MP0008438_abnormal_cutaneous_collagen0.73392099
147MP0002398_abnormal_bone_marrow0.72995215
148MP0009384_cardiac_valve_regurgitation0.71729920
149MP0002067_abnormal_sensory_capabilities0.71322991
150MP0005376_homeostasis/metabolism_phenot0.71033305
151MP0008874_decreased_physiological_sensi0.70862769
152MP0004185_abnormal_adipocyte_glucose0.70255602
153MP0002876_abnormal_thyroid_physiology0.68071030
154MP0005423_abnormal_somatic_nervous0.67498992
155MP0002896_abnormal_bone_mineralization0.66904029
156MP0002069_abnormal_eating/drinking_beha0.66719208
157MP0004085_abnormal_heartbeat0.66270189
158MP0002066_abnormal_motor_capabilities/c0.65864050
159MP0004272_abnormal_basement_membrane0.65592715
160MP0008872_abnormal_physiological_respon0.64980492
161MP0000955_abnormal_spinal_cord0.64383248
162MP0005334_abnormal_fat_pad0.63616903
163MP0000639_abnormal_adrenal_gland0.63536438
164MP0001765_abnormal_ion_homeostasis0.63385029
165MP0003690_abnormal_glial_cell0.63040073
166MP0002184_abnormal_innervation0.63004665
167MP0005084_abnormal_gallbladder_morpholo0.61472778
168MP0009643_abnormal_urine_homeostasis0.60991537
169MP0003631_nervous_system_phenotype0.60326842
170MP0003953_abnormal_hormone_level0.58801450
171MP0000230_abnormal_systemic_arterial0.58634742
172MP0001970_abnormal_pain_threshold0.58570205
173MP0005646_abnormal_pituitary_gland0.58258134

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.28839927
2Eczematoid dermatitis (HP:0000976)4.66757279
3Recurrent gram-negative bacterial infections (HP:0005420)4.37704970
4Peritonitis (HP:0002586)4.30273783
5Orchitis (HP:0100796)4.22410405
6Intrahepatic cholestasis (HP:0001406)4.10435976
7Myositis (HP:0100614)4.03359521
8Gastrointestinal infarctions (HP:0005244)3.92831702
9Optic neuritis (HP:0100653)3.92238726
10Retrobulbar optic neuritis (HP:0100654)3.92238726
11Abnormality of aromatic amino acid family metabolism (HP:0004338)3.74163803
12Gingival bleeding (HP:0000225)3.72892109
13Xanthomatosis (HP:0000991)3.69320815
14Recurrent abscess formation (HP:0002722)3.60953620
15Abnormality of monocarboxylic acid metabolism (HP:0010996)3.52404798
16Recurrent bacterial skin infections (HP:0005406)3.52382666
17Hypobetalipoproteinemia (HP:0003563)3.50415760
18Spontaneous hematomas (HP:0007420)3.43453649
19Hypochromic microcytic anemia (HP:0004840)3.17195978
20Ketosis (HP:0001946)3.12129507
21Hyperlipoproteinemia (HP:0010980)3.11302925
22Complement deficiency (HP:0004431)3.05795926
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.04921214
24Epidermoid cyst (HP:0200040)3.02847443
25Abnormality of macrophages (HP:0004311)3.01204704
26Keratoconjunctivitis sicca (HP:0001097)2.95368047
27Ketoacidosis (HP:0001993)2.91199664
28Pulmonary embolism (HP:0002204)2.89258454
29Myokymia (HP:0002411)2.87661816
30Gingivitis (HP:0000230)2.82877741
31Amyloidosis (HP:0011034)2.82514614
32Hypolipoproteinemia (HP:0010981)2.76207958
33Hypochromic anemia (HP:0001931)2.72059734
34Hyperglycinemia (HP:0002154)2.70829742
35Papillary thyroid carcinoma (HP:0002895)2.68896315
36Subacute progressive viral hepatitis (HP:0006572)2.66823015
37Joint hemorrhage (HP:0005261)2.66778664
38Focal motor seizures (HP:0011153)2.63746821
39Hyperammonemia (HP:0001987)2.63511526
40Gout (HP:0001997)2.61910353
41Prolonged partial thromboplastin time (HP:0003645)2.60341412
42Abnormality of the peritoneum (HP:0002585)2.59445224
43Abnormality of the lower motor neuron (HP:0002366)2.58985044
44Hyperglycinuria (HP:0003108)2.58390617
45Polycythemia (HP:0001901)2.56239315
46Hypoalphalipoproteinemia (HP:0003233)2.55866780
47Systemic lupus erythematosus (HP:0002725)2.55183201
48Episodic fever (HP:0001954)2.53862802
49Abnormality of glycine metabolism (HP:0010895)2.53267082
50Abnormality of serine family amino acid metabolism (HP:0010894)2.53267082
51Prolonged bleeding time (HP:0003010)2.52971192
52Keratoconjunctivitis (HP:0001096)2.52032383
53Focal seizures (HP:0007359)2.51554712
54Insidious onset (HP:0003587)2.49821602
55Termporal pattern (HP:0011008)2.49821602
56Abnormality of the common coagulation pathway (HP:0010990)2.48909450
57Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.46430286
58Visual hallucinations (HP:0002367)2.45813671
59Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.44503044
60Status epilepticus (HP:0002133)2.41783611
61Action tremor (HP:0002345)2.40397035
62Arterial thrombosis (HP:0004420)2.38273776
63Skin nodule (HP:0200036)2.35792907
64Recurrent skin infections (HP:0001581)2.35449191
65Epistaxis (HP:0000421)2.34352976
66Hypoglycemic coma (HP:0001325)2.27360453
67Thrombophlebitis (HP:0004418)2.25273016
68Back pain (HP:0003418)2.24958242
69Impaired vibration sensation in the lower limbs (HP:0002166)2.23247437
70Abnormal delayed hypersensitivity skin test (HP:0002963)2.20382273
71Osteomalacia (HP:0002749)2.20366912
72Abnormality of sulfur amino acid metabolism (HP:0004339)2.19400154
73Hypercholesterolemia (HP:0003124)2.19290786
74Lymphangioma (HP:0100764)2.17568213
75Obstructive lung disease (HP:0006536)2.16983098
76Chronic obstructive pulmonary disease (HP:0006510)2.16983098
77Cerebral inclusion bodies (HP:0100314)2.16380077
78Urticaria (HP:0001025)2.14311205
79Cholecystitis (HP:0001082)2.14034382
80Abnormal gallbladder physiology (HP:0012438)2.14034382
81Glomerulonephritis (HP:0000099)2.13940674
82Segmental peripheral demyelination/remyelination (HP:0003481)2.12576174
83Difficulty running (HP:0009046)2.12502590
84Abnormal social behavior (HP:0012433)2.10159110
85Impaired social interactions (HP:0000735)2.10159110
86Meningitis (HP:0001287)2.09783668
87Abnormality of the intrinsic pathway (HP:0010989)2.08812884
88Encephalitis (HP:0002383)2.08439338
89Abnormality of purine metabolism (HP:0004352)2.08391275
90Increased IgE level (HP:0003212)2.08355345
91Sensorimotor neuropathy (HP:0007141)2.07141526
92Hemorrhage of the eye (HP:0011885)2.07062182
93Turricephaly (HP:0000262)2.06201847
94Neonatal onset (HP:0003623)2.05502140
95Thickened calvaria (HP:0002684)2.05463917
96Torticollis (HP:0000473)2.05384847
97Vasculitis (HP:0002633)2.05372405
98Muscle fiber splitting (HP:0003555)2.04606926
99Ventricular fibrillation (HP:0001663)2.01954326
100Generalized tonic-clonic seizures (HP:0002069)2.01618734
101Hyperventilation (HP:0002883)2.00104673
102Absence seizures (HP:0002121)1.99860028
103Chest pain (HP:0100749)1.99449452
104Abnormality of the Achilles tendon (HP:0005109)1.99154874
105Metaphyseal cupping (HP:0003021)1.98903191
106Malnutrition (HP:0004395)1.97652375
107Fat malabsorption (HP:0002630)1.97337110
108Arterial tortuosity (HP:0005116)1.96900548
109Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96665957
110Elevated erythrocyte sedimentation rate (HP:0003565)1.96271360
111Microcytic anemia (HP:0001935)1.95417365
112Cellulitis (HP:0100658)1.95167500
113Spontaneous abortion (HP:0005268)1.95043505
114Vascular tortuosity (HP:0004948)1.94501897
115Macroorchidism (HP:0000053)1.94170382
116Subaortic stenosis (HP:0001682)1.93732354
117Abnormality of the left ventricular outflow tract (HP:0011103)1.93732354
118Enlarged penis (HP:0000040)1.93047641
119Abnormal platelet volume (HP:0011876)1.92557180
120Mitral stenosis (HP:0001718)1.91909853
121Spastic diplegia (HP:0001264)1.89438062
122Mediastinal lymphadenopathy (HP:0100721)1.89301619
123Hepatocellular carcinoma (HP:0001402)1.88641382
124Urinary bladder sphincter dysfunction (HP:0002839)1.86529565
125Papilledema (HP:0001085)1.86490495
126Buphthalmos (HP:0000557)1.84985405
127Anorexia (HP:0002039)1.84423387
128Delayed CNS myelination (HP:0002188)1.83960507
129Abnormality of complement system (HP:0005339)1.83393274
130Recurrent fungal infections (HP:0002841)1.83091217
131Hemoptysis (HP:0002105)1.82963053
132Obstructive sleep apnea (HP:0002870)1.82881760
133Focal dystonia (HP:0004373)1.82811156
134Hyperglycemia (HP:0003074)1.82791247
135Menorrhagia (HP:0000132)1.82721315
136Dilatation of the ascending aorta (HP:0005111)1.82355813
137Neurofibrillary tangles (HP:0002185)1.81916337
138Purpura (HP:0000979)1.81239805
139Urinary urgency (HP:0000012)1.81231365
140Postural instability (HP:0002172)1.80932210
141Craniofacial dystonia (HP:0012179)1.80756595
142Atonic seizures (HP:0010819)1.80458236
143Conjugated hyperbilirubinemia (HP:0002908)1.78526536
144Acanthocytosis (HP:0001927)1.78197537
145Agitation (HP:0000713)1.77840629
146Hepatoblastoma (HP:0002884)1.77614755
147Hypoglycemic seizures (HP:0002173)1.77479907
148Abnormality of proline metabolism (HP:0010907)1.75868489
149Hydroxyprolinuria (HP:0003080)1.75868489
150Slow saccadic eye movements (HP:0000514)1.75717540
151Acute hepatic failure (HP:0006554)1.75521567
152Bronchomalacia (HP:0002780)1.75378869
153Abnormality of the endocardium (HP:0004306)1.75374499
154Genetic anticipation (HP:0003743)1.75135994
155Viral hepatitis (HP:0006562)1.74534593
156Excessive salivation (HP:0003781)1.74495438
157Drooling (HP:0002307)1.74495438
158Anxiety (HP:0000739)1.73354482
159Dysdiadochokinesis (HP:0002075)1.72779389
160Gangrene (HP:0100758)1.71605283
161Poor eye contact (HP:0000817)1.69128863
162Depression (HP:0000716)1.68988689
163Aortic aneurysm (HP:0004942)1.68248423
164Onion bulb formation (HP:0003383)1.67198408
165Arthropathy (HP:0003040)1.66896773
166Toxemia of pregnancy (HP:0100603)1.66670093
167Lower limb asymmetry (HP:0100559)1.66525740
168Progressive cerebellar ataxia (HP:0002073)1.66435094
169Hyperuricemia (HP:0002149)1.66265084
170Increased purine levels (HP:0004368)1.66265084
171Stomatitis (HP:0010280)1.65659965
172Hyperinsulinemic hypoglycemia (HP:0000825)1.65178632
173Supranuclear gaze palsy (HP:0000605)1.64207556
174Stomach cancer (HP:0012126)1.63326654
175Dysmetric saccades (HP:0000641)1.62869463
176Flat acetabular roof (HP:0003180)1.62844373
177Abnormal eating behavior (HP:0100738)1.62528536
178Long toe (HP:0010511)1.62278854
179Global brain atrophy (HP:0002283)1.62135997
180Ankle clonus (HP:0011448)1.61800743
181Hamartoma of the eye (HP:0010568)1.61751902
182Cortical dysplasia (HP:0002539)1.61750204
183Potter facies (HP:0002009)1.60997308
184Acne (HP:0001061)1.58941724
185Striae distensae (HP:0001065)1.58358271
186Thin bony cortex (HP:0002753)1.58267291
187Periodontitis (HP:0000704)1.57969311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.44429532
2MAP3K93.29129500
3NTRK33.05598136
4PKN23.00991961
5TRIB32.99985994
6EPHA42.46835195
7MAP2K32.44554714
8MAP3K42.34110382
9MAP2K42.33283192
10MARK12.27389647
11KSR22.19102404
12PRPF4B2.17198836
13TYK22.16775593
14FGFR32.09342214
15EPHB12.05211481
16LATS12.04679547
17LATS22.03187520
18YES12.02682631
19IRAK41.97244228
20PRKD31.96649839
21CSK1.90669921
22DAPK21.75928652
23MAP3K21.71744685
24MINK11.70720346
25BLK1.69565690
26AKT31.65453412
27STK381.63527729
28FRK1.63269356
29SIK11.61929746
30RET1.58476716
31NTRK11.58089881
32JAK21.57398699
33PAK61.56112957
34GRK61.54878111
35RIPK11.47028276
36CAMKK11.45905741
37FES1.43456762
38MAP2K71.40057716
39DYRK1B1.37540447
40KSR11.36708336
41ZAP701.29340938
42JAK11.27322429
43PDGFRA1.26907697
44MARK21.26156401
45NTRK21.25759702
46TYRO31.24153240
47PTK61.23400309
48MAP3K31.23252336
49LMTK21.22497457
50HCK1.21918565
51PAK31.17293372
52FGFR21.17168555
53MAP3K131.15826269
54EPHA31.15283780
55TNK21.11393019
56DDR21.11057453
57PDK41.07341179
58PDK31.07341179
59MAP3K71.06542930
60BCKDK1.04450625
61CAMK1G1.00576396
62FGR1.00135713
63PHKG21.00016103
64PHKG11.00016103
65FER0.99943810
66INSRR0.99722753
67JAK30.94694981
68MAP3K110.92762679
69CDK50.91711873
70IRAK20.91296558
71SGK30.89890489
72CAMKK20.89205335
73PTK20.88933815
74RAF10.88813960
75TAOK10.88218498
76PIK3CG0.84892490
77WNK40.84808126
78ERBB40.84317843
79CDK120.82156901
80MAP3K50.81558519
81CSNK1G20.81387178
82STK110.81342663
83TAOK30.81265881
84MST1R0.80931454
85NLK0.80109592
86FGFR40.79718810
87IRAK10.76437241
88EPHB20.75513233
89CDK190.74866662
90PRKCH0.74806074
91MAP2K10.74587837
92SIK20.74318193
93SGK2230.73526344
94SGK4940.73526344
95PRKCZ0.72408942
96MAP3K140.72331794
97WNK30.71776660
98MAP4K10.71268756
99HIPK20.71114440
100GRK50.71043251
101PDPK10.70667845
102MAPK120.70615108
103SGK20.69530858
104PRKCG0.67810680
105BTK0.66896807
106MAP3K10.66778123
107IKBKE0.66243889
108DYRK1A0.65971572
109SYK0.65874292
110MAP3K60.65839576
111FYN0.65036580
112ICK0.65034295
113NEK10.63718527
114PDK10.63400116
115PRKD20.62998837
116CASK0.62950330
117LYN0.62594089
118PRKAA10.61675785
119CAMK1D0.61353950
120FGFR10.60994442
121PLK20.60311612
122CAMK2A0.60146489
123TGFBR20.60106355
124STK240.59967941
125MOS0.58488782
126SIK30.58084957
127STK30.57135270
128CAMK40.56612077
129SGK10.55360222
130PNCK0.54625678
131PTK2B0.53879927
132NEK60.52583271
133ERBB20.52131868
134DMPK0.51901360
135LCK0.51549732
136CDK60.50992156
137MATK0.50590636
138BRD40.49986723
139WNK10.49348124
140ERN10.48871194
141RPS6KA30.47719817
142ALK0.46713244
143BMX0.46551123
144MAPK70.46442228
145PRKAA20.46163483
146NEK90.46061592
147BMPR20.44547253
148STK38L0.44266517
149MAP3K120.44192847
150PDGFRB0.44181582
151SCYL20.43757229
152CDK140.43000840
153ROCK10.42273723
154DAPK10.41798882
155UHMK10.41647937
156CSNK1G10.41153201
157PINK10.40274875

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.92084662
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.84474414
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.73325950
4Arginine biosynthesis_Homo sapiens_hsa002202.56139970
5Staphylococcus aureus infection_Homo sapiens_hsa051502.11798240
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.09180679
7Butanoate metabolism_Homo sapiens_hsa006501.91204001
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.88799807
9Tryptophan metabolism_Homo sapiens_hsa003801.84419078
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83393045
11Bile secretion_Homo sapiens_hsa049761.81702756
12Osteoclast differentiation_Homo sapiens_hsa043801.78802504
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75972154
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.71763232
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68115675
16Fatty acid degradation_Homo sapiens_hsa000711.67367518
17Leishmaniasis_Homo sapiens_hsa051401.57710486
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56401996
19PPAR signaling pathway_Homo sapiens_hsa033201.53324423
20Propanoate metabolism_Homo sapiens_hsa006401.51962241
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47899556
22Non-small cell lung cancer_Homo sapiens_hsa052231.47379797
23Complement and coagulation cascades_Homo sapiens_hsa046101.41081228
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38598889
25Fatty acid metabolism_Homo sapiens_hsa012121.37439529
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35028458
27B cell receptor signaling pathway_Homo sapiens_hsa046621.33614646
28Acute myeloid leukemia_Homo sapiens_hsa052211.31021209
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30470887
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21001590
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17075475
32Tuberculosis_Homo sapiens_hsa051521.16344639
33Nicotine addiction_Homo sapiens_hsa050331.15772320
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15469419
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15165604
36Pancreatic cancer_Homo sapiens_hsa052121.14542673
37Fatty acid biosynthesis_Homo sapiens_hsa000611.14492549
38Prolactin signaling pathway_Homo sapiens_hsa049171.11857566
39GABAergic synapse_Homo sapiens_hsa047271.11587449
40Chronic myeloid leukemia_Homo sapiens_hsa052201.11124661
41Renal cell carcinoma_Homo sapiens_hsa052111.10307893
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09434573
43Chemokine signaling pathway_Homo sapiens_hsa040621.09223850
44Endometrial cancer_Homo sapiens_hsa052131.08349325
45Caffeine metabolism_Homo sapiens_hsa002321.08191665
46Pyruvate metabolism_Homo sapiens_hsa006201.07802189
47Phenylalanine metabolism_Homo sapiens_hsa003601.05916915
48Choline metabolism in cancer_Homo sapiens_hsa052311.04984718
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04779418
50Synaptic vesicle cycle_Homo sapiens_hsa047211.02705434
51Fat digestion and absorption_Homo sapiens_hsa049751.02262910
52Amphetamine addiction_Homo sapiens_hsa050311.01244176
53NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01171698
54Long-term potentiation_Homo sapiens_hsa047201.01140876
55VEGF signaling pathway_Homo sapiens_hsa043700.99884503
56Platelet activation_Homo sapiens_hsa046110.99538825
57Sulfur metabolism_Homo sapiens_hsa009200.99474799
58Inositol phosphate metabolism_Homo sapiens_hsa005620.99142211
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98907546
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98425297
61beta-Alanine metabolism_Homo sapiens_hsa004100.97708327
62Starch and sucrose metabolism_Homo sapiens_hsa005000.96928615
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.96869754
64FoxO signaling pathway_Homo sapiens_hsa040680.96686744
65Peroxisome_Homo sapiens_hsa041460.96143344
66ErbB signaling pathway_Homo sapiens_hsa040120.95091897
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94617158
68Insulin secretion_Homo sapiens_hsa049110.93666861
69Glutamatergic synapse_Homo sapiens_hsa047240.91952067
70Cocaine addiction_Homo sapiens_hsa050300.91895369
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91548137
72Dopaminergic synapse_Homo sapiens_hsa047280.90087723
73Circadian entrainment_Homo sapiens_hsa047130.90037951
74Malaria_Homo sapiens_hsa051440.89547206
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.89110785
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.88687293
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87005211
78Tyrosine metabolism_Homo sapiens_hsa003500.86979738
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86886322
80Hepatitis C_Homo sapiens_hsa051600.86235656
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86174576
82Amoebiasis_Homo sapiens_hsa051460.86151977
83Histidine metabolism_Homo sapiens_hsa003400.85773209
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.85527275
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.85296552
86Renin secretion_Homo sapiens_hsa049240.85092999
87Glucagon signaling pathway_Homo sapiens_hsa049220.83576667
88Salivary secretion_Homo sapiens_hsa049700.83503762
89Measles_Homo sapiens_hsa051620.83389239
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82080593
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81860634
92T cell receptor signaling pathway_Homo sapiens_hsa046600.81320750
93Chemical carcinogenesis_Homo sapiens_hsa052040.81068133
94Gastric acid secretion_Homo sapiens_hsa049710.80676985
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80512216
96Olfactory transduction_Homo sapiens_hsa047400.79658988
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78481183
98Toxoplasmosis_Homo sapiens_hsa051450.78358522
99Type II diabetes mellitus_Homo sapiens_hsa049300.77646505
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.76243278
101Phagosome_Homo sapiens_hsa041450.76136076
102Pertussis_Homo sapiens_hsa051330.75242597
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72626818
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72489622
105Glycerolipid metabolism_Homo sapiens_hsa005610.71703200
106African trypanosomiasis_Homo sapiens_hsa051430.71309440
107Lysine degradation_Homo sapiens_hsa003100.71239241
108Carbon metabolism_Homo sapiens_hsa012000.71106018
109TNF signaling pathway_Homo sapiens_hsa046680.70026846
110Morphine addiction_Homo sapiens_hsa050320.69934270
111Cholinergic synapse_Homo sapiens_hsa047250.68405189
112Influenza A_Homo sapiens_hsa051640.67261458
113GnRH signaling pathway_Homo sapiens_hsa049120.66722141
114Dorso-ventral axis formation_Homo sapiens_hsa043200.66595299
115Retinol metabolism_Homo sapiens_hsa008300.66549734
116Biosynthesis of amino acids_Homo sapiens_hsa012300.65821347
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65814376
118Hepatitis B_Homo sapiens_hsa051610.65778523
119Selenocompound metabolism_Homo sapiens_hsa004500.64038890
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.63580483
121Thyroid hormone synthesis_Homo sapiens_hsa049180.63546428
122Endocytosis_Homo sapiens_hsa041440.62789981
123Estrogen signaling pathway_Homo sapiens_hsa049150.62060635
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61967639
125Insulin resistance_Homo sapiens_hsa049310.61856480
126ABC transporters_Homo sapiens_hsa020100.59610903
127Oxytocin signaling pathway_Homo sapiens_hsa049210.59543574
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59519572
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59518817
130Gap junction_Homo sapiens_hsa045400.58527693
131Rap1 signaling pathway_Homo sapiens_hsa040150.58435431
132Long-term depression_Homo sapiens_hsa047300.58310488
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.57722767
134Glioma_Homo sapiens_hsa052140.57527233
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57235540
136Insulin signaling pathway_Homo sapiens_hsa049100.57211751
137Colorectal cancer_Homo sapiens_hsa052100.56616081
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.56217409
139mTOR signaling pathway_Homo sapiens_hsa041500.55593168
140Prostate cancer_Homo sapiens_hsa052150.54916674
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54879352
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54743214
143AMPK signaling pathway_Homo sapiens_hsa041520.54588889
144Cysteine and methionine metabolism_Homo sapiens_hsa002700.54543461
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54502664
146Legionellosis_Homo sapiens_hsa051340.49525544
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48747578
148MAPK signaling pathway_Homo sapiens_hsa040100.47524001
149Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47419335
150cAMP signaling pathway_Homo sapiens_hsa040240.47355700
151Thyroid cancer_Homo sapiens_hsa052160.46996788
152Prion diseases_Homo sapiens_hsa050200.46391973
153cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45804136
154Taste transduction_Homo sapiens_hsa047420.45598154
155Ovarian steroidogenesis_Homo sapiens_hsa049130.44382274
156Drug metabolism - other enzymes_Homo sapiens_hsa009830.44018063
157Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42643911
158Melanogenesis_Homo sapiens_hsa049160.42400268
159Serotonergic synapse_Homo sapiens_hsa047260.38791707

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