FAM90A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: FAM90A1 belongs to subfamily I of the primate-specific FAM90A gene family, which originated from multiple duplications and rearrangements (Bosch et al., 2007 [PubMed 17684299]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.04037449
2response to pheromone (GO:0019236)8.34241692
3sperm capacitation (GO:0048240)7.41934399
4spermatid development (GO:0007286)7.34793595
5spermatid nucleus differentiation (GO:0007289)7.30012737
6chromosome condensation (GO:0030261)7.16472545
7microtubule depolymerization (GO:0007019)7.04405361
8DNA packaging (GO:0006323)7.00210014
9plasma membrane fusion (GO:0045026)6.94446357
10multicellular organism reproduction (GO:0032504)6.82108604
11sperm-egg recognition (GO:0035036)6.53347783
12protein polyglutamylation (GO:0018095)6.43325567
13single strand break repair (GO:0000012)6.27121668
14calcium ion-dependent exocytosis (GO:0017156)6.26923904
15reproduction (GO:0000003)6.14105744
16protein targeting to Golgi (GO:0000042)6.09044483
17binding of sperm to zona pellucida (GO:0007339)5.92563710
18establishment of protein localization to Golgi (GO:0072600)5.85212208
19microtubule polymerization or depolymerization (GO:0031109)5.75480595
20retrograde transport, vesicle recycling within Golgi (GO:0000301)5.55735721
21cell-cell recognition (GO:0009988)5.48381814
22negative regulation of inclusion body assembly (GO:0090084)5.47280770
23axonemal dynein complex assembly (GO:0070286)5.31784985
24spermatogenesis (GO:0007283)5.24689117
25male gamete generation (GO:0048232)5.22591946
26sexual reproduction (GO:0019953)5.16456395
27microtubule severing (GO:0051013)5.14992954
28rRNA methylation (GO:0031167)5.08850993
29phosphatidylethanolamine biosynthetic process (GO:0006646)5.01867949
30motile cilium assembly (GO:0044458)4.93456717
31gamete generation (GO:0007276)4.82228726
32cellular ketone body metabolic process (GO:0046950)4.80331552
33phosphatidylethanolamine metabolic process (GO:0046337)4.74759528
34cilium or flagellum-dependent cell motility (GO:0001539)4.72055319
35single fertilization (GO:0007338)4.71651795
36protein localization to Golgi apparatus (GO:0034067)4.68179186
37regulation of Rab GTPase activity (GO:0032313)4.66067877
38positive regulation of Rab GTPase activity (GO:0032851)4.66067877
39regulation of cilium movement (GO:0003352)4.59290357
40cell wall macromolecule catabolic process (GO:0016998)4.54299227
41histone H3-K9 demethylation (GO:0033169)4.53956324
42epithelial cilium movement (GO:0003351)4.35287968
43seminiferous tubule development (GO:0072520)4.28314379
44cell wall macromolecule metabolic process (GO:0044036)4.23719725
45ketone body metabolic process (GO:1902224)4.19458803
46germ cell development (GO:0007281)4.15339137
47rRNA modification (GO:0000154)4.08125229
48fertilization (GO:0009566)4.06568120
49centriole replication (GO:0007099)3.92281561
50cellular process involved in reproduction in multicellular organism (GO:0022412)3.90872459
51multicellular organismal reproductive process (GO:0048609)3.82604427
52cilium movement (GO:0003341)3.82414008
53male meiosis (GO:0007140)3.77205282
54coenzyme catabolic process (GO:0009109)3.76564708
55regulation of transcription involved in cell fate commitment (GO:0060850)3.72431758
56RNA destabilization (GO:0050779)3.69544765
57regulation of inclusion body assembly (GO:0090083)3.68190034
58centriole assembly (GO:0098534)3.64814372
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.63956775
60chromatin silencing (GO:0006342)3.61973413
61regulation of microtubule-based movement (GO:0060632)3.49512810
62male meiosis I (GO:0007141)3.44826651
63nucleus organization (GO:0006997)3.40302693
64piRNA metabolic process (GO:0034587)3.38472718
65cerebral cortex neuron differentiation (GO:0021895)3.37250453
66ventricular system development (GO:0021591)3.32369533
67somite rostral/caudal axis specification (GO:0032525)3.27920301
68response to acidic pH (GO:0010447)3.26806257
69musculoskeletal movement (GO:0050881)3.17819059
70multicellular organismal movement (GO:0050879)3.17819059
71negative regulation of Rho protein signal transduction (GO:0035024)3.17449943
72organic cation transport (GO:0015695)3.17054010
73DNA methylation involved in gamete generation (GO:0043046)3.14569565
74polyamine biosynthetic process (GO:0006596)3.10666637
75cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.09011594
76cell recognition (GO:0008037)3.02825870
77cellular response to pH (GO:0071467)3.02655764
78regulation of T-helper 2 cell differentiation (GO:0045628)3.01864527
79regulation of phosphoprotein phosphatase activity (GO:0043666)2.99749582
80cranial nerve morphogenesis (GO:0021602)2.97987130
81regulation of centriole replication (GO:0046599)2.95539486
82vesicle transport along microtubule (GO:0047496)2.95337130
83microtubule nucleation (GO:0007020)2.92978576
84epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.85447721
85regulation of interleukin-13 production (GO:0032656)2.83354905
86actin filament capping (GO:0051693)2.80935058
87cell differentiation involved in metanephros development (GO:0072202)2.73010241
88NAD biosynthetic process (GO:0009435)2.71228461
89multicellular organismal development (GO:0007275)2.68910133
90negative regulation of gene expression, epigenetic (GO:0045814)2.68812601
91regulation of ARF GTPase activity (GO:0032312)2.67216801
92peptidyl-threonine dephosphorylation (GO:0035970)2.65258420
93membrane depolarization during action potential (GO:0086010)2.63677845
94positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.62635150
95membrane protein intracellular domain proteolysis (GO:0031293)2.61355715
96meiosis I (GO:0007127)2.60490170
97neurofilament cytoskeleton organization (GO:0060052)2.58771414
98protein depolymerization (GO:0051261)2.57604518
99acrosome reaction (GO:0007340)10.7952316
100sperm motility (GO:0030317)10.1378817

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.04166745
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.19653832
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.16718363
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.72127001
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.34642316
6DROSHA_22980978_ChIP-Seq_HELA_Human2.34326423
7CTBP1_25329375_ChIP-Seq_LNCAP_Human2.30613934
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11887966
9GBX2_23144817_ChIP-Seq_PC3_Human2.01785182
10VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.95360633
11CBP_20019798_ChIP-Seq_JUKART_Human1.91509577
12IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.91509577
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.88634524
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88634524
15WDR5_24793694_ChIP-Seq_LNCAP_Human1.70764856
16FUS_26573619_Chip-Seq_HEK293_Human1.68777404
17ELF1_20517297_ChIP-Seq_JURKAT_Human1.67766727
18ERA_21632823_ChIP-Seq_H3396_Human1.66273657
19SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63409026
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62668618
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62388590
22TAF15_26573619_Chip-Seq_HEK293_Human1.62067642
23RAC3_21632823_ChIP-Seq_H3396_Human1.60500682
24CTCF_27219007_Chip-Seq_Bcells_Human1.55491467
25ZNF274_21170338_ChIP-Seq_K562_Hela1.54486932
26UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53949708
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.51529110
28SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48719729
29* NANOG_20526341_ChIP-Seq_ESCs_Human1.47388769
30REST_21632747_ChIP-Seq_MESCs_Mouse1.46490745
31MYC_19829295_ChIP-Seq_ESCs_Human1.46161543
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45395241
33RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.45142666
34AR_25329375_ChIP-Seq_VCAP_Human1.44720424
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43299630
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42692381
37EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.42581979
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41722888
39BCL6_27268052_Chip-Seq_Bcells_Human1.41201180
40EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.39744242
41OCT4_20526341_ChIP-Seq_ESCs_Human1.39714392
42TAF2_19829295_ChIP-Seq_ESCs_Human1.38078475
43E2F1_20622854_ChIP-Seq_HELA_Human1.33656139
44SMAD4_21799915_ChIP-Seq_A2780_Human1.33027288
45CTCF_20526341_ChIP-Seq_ESCs_Human1.32397458
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31835913
47SMC4_20622854_ChIP-Seq_HELA_Human1.31138250
48PHF8_20622854_ChIP-Seq_HELA_Human1.29819522
49YY1_22570637_ChIP-Seq_MALME-3M_Human1.29315181
50* SMAD4_21741376_ChIP-Seq_EPCs_Human1.28930538
51ER_23166858_ChIP-Seq_MCF-7_Human1.28872809
52* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25384067
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24996280
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24859960
55AR_21572438_ChIP-Seq_LNCaP_Human1.24453185
56P300_19829295_ChIP-Seq_ESCs_Human1.23841935
57EZH2_27304074_Chip-Seq_ESCs_Mouse1.23405890
58P68_20966046_ChIP-Seq_HELA_Human1.22877924
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.22494673
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21879282
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.20718623
62STAT3_23295773_ChIP-Seq_U87_Human1.20236027
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19813990
64BCOR_27268052_Chip-Seq_Bcells_Human1.19074770
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.18761884
66JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18717463
67TDRD3_21172665_ChIP-Seq_MCF-7_Human1.18449035
68TP63_22573176_ChIP-Seq_HFKS_Human1.18088826
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.17500021
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.17156374
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16148300
72SMAD3_21741376_ChIP-Seq_ESCs_Human1.15532629
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15118765
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13749687
75SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11834679
76TP53_18474530_ChIP-ChIP_U2OS_Human1.11771098
77ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11214642
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10272841
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08770346
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08606114
81* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08324355
82RUNX2_22187159_ChIP-Seq_PCA_Human1.08192439
83BP1_19119308_ChIP-ChIP_Hs578T_Human1.07355353
84MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06101586
85P300_27268052_Chip-Seq_Bcells_Human1.06025693
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05346812
87JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05164939
88SMAD4_21741376_ChIP-Seq_HESCs_Human1.04157022
89TBL1_22424771_ChIP-Seq_293T_Human1.03720016
90OCT1_27270436_Chip-Seq_PROSTATE_Human1.03623834
91ERG_20517297_ChIP-Seq_VCAP_Human1.02380771
92CBX2_22325352_ChIP-Seq_293T-Rex_Human1.01944981
93HNFA_21074721_ChIP-Seq_CACO-2_Human1.00048254
94ETV1_20927104_ChIP-Seq_GIST48_Human1.00028585
95OCT4_19829295_ChIP-Seq_ESCs_Human0.97788716
96CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.97357660
97KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.97288291
98KLF4_19829295_ChIP-Seq_ESCs_Human0.96477845
99SOX2_22085726_ChIP-Seq_NPCs_Mouse0.96212241
100EED_16625203_ChIP-ChIP_MESCs_Mouse0.96031010

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.79441523
2MP0005670_abnormal_white_adipose4.22647003
3MP0003698_abnormal_male_reproductive3.93530485
4MP0005377_hearing/vestibular/ear_phenot3.59842132
5MP0003878_abnormal_ear_physiology3.59842132
6MP0001929_abnormal_gametogenesis3.31045195
7MP0004859_abnormal_synaptic_plasticity2.34676096
8MP0001486_abnormal_startle_reflex2.26891921
9MP0002132_abnormal_respiratory_system2.21484893
10MP0002161_abnormal_fertility/fecundity2.19774961
11MP0000678_abnormal_parathyroid_gland2.19309853
12MP0002735_abnormal_chemical_nociception2.05870967
13MP0001984_abnormal_olfaction2.02891878
14MP0005423_abnormal_somatic_nervous1.99329875
15MP0004742_abnormal_vestibular_system1.90435755
16MP0001968_abnormal_touch/_nociception1.80585607
17MP0002234_abnormal_pharynx_morphology1.76482098
18MP0001348_abnormal_lacrimal_gland1.76303304
19MP0004270_analgesia1.74548493
20MP0003635_abnormal_synaptic_transmissio1.70752946
21MP0009745_abnormal_behavioral_response1.69012401
22MP0003718_maternal_effect1.65713228
23MP0002653_abnormal_ependyma_morphology1.64755994
24MP0002210_abnormal_sex_determination1.63199830
25MP0003879_abnormal_hair_cell1.60959090
26MP0002272_abnormal_nervous_system1.60817807
27MP0001501_abnormal_sleep_pattern1.56188497
28MP0002249_abnormal_larynx_morphology1.53573723
29MP0001485_abnormal_pinna_reflex1.52560457
30MP0009046_muscle_twitch1.49832678
31MP0008877_abnormal_DNA_methylation1.46842660
32MP0002067_abnormal_sensory_capabilities1.43425851
33MP0003646_muscle_fatigue1.38982684
34MP0001145_abnormal_male_reproductive1.37061371
35MP0005499_abnormal_olfactory_system1.33894307
36MP0005394_taste/olfaction_phenotype1.33894307
37MP0002572_abnormal_emotion/affect_behav1.33545749
38MP0002064_seizures1.31647413
39MP0001963_abnormal_hearing_physiology1.30933202
40MP0002733_abnormal_thermal_nociception1.30904189
41MP0000653_abnormal_sex_gland1.30670020
42MP0002229_neurodegeneration1.30302948
43MP0002127_abnormal_cardiovascular_syste1.30102913
44MP0000026_abnormal_inner_ear1.23752355
45MP0003880_abnormal_central_pattern1.20431301
46MP0005248_abnormal_Harderian_gland1.15027729
47MP0002063_abnormal_learning/memory/cond1.14538725
48MP0001440_abnormal_grooming_behavior1.11773239
49MP0002557_abnormal_social/conspecific_i1.10850403
50MP0000955_abnormal_spinal_cord1.10610959
51MP0002734_abnormal_mechanical_nocicepti1.10053595
52MP0002822_catalepsy1.08699101
53MP0005379_endocrine/exocrine_gland_phen1.08143272
54MP0005551_abnormal_eye_electrophysiolog1.06571253
55MP0004510_myositis1.04478762
56MP0001970_abnormal_pain_threshold1.03774170
57MP0003011_delayed_dark_adaptation1.03484765
58MP0000681_abnormal_thyroid_gland0.99218940
59MP0002282_abnormal_trachea_morphology0.97551338
60MP0005645_abnormal_hypothalamus_physiol0.97376064
61MP0001905_abnormal_dopamine_level0.96953504
62MP0008569_lethality_at_weaning0.95570406
63MP0004085_abnormal_heartbeat0.94624243
64MP0001529_abnormal_vocalization0.93359784
65MP0005253_abnormal_eye_physiology0.91837040
66MP0003633_abnormal_nervous_system0.90086545
67MP0002882_abnormal_neuron_morphology0.89171887
68MP0000516_abnormal_urinary_system0.88699611
69MP0005367_renal/urinary_system_phenotyp0.88699611
70MP0003631_nervous_system_phenotype0.88526974
71MP0006276_abnormal_autonomic_nervous0.88341990
72MP0009115_abnormal_fat_cell0.86565927
73MP0004811_abnormal_neuron_physiology0.85379430
74MP0008789_abnormal_olfactory_epithelium0.84768603
75MP0000569_abnormal_digit_pigmentation0.81455308
76MP0001765_abnormal_ion_homeostasis0.77761676
77MP0000049_abnormal_middle_ear0.77374936
78MP0005310_abnormal_salivary_gland0.76510232
79MP0003329_amyloid_beta_deposits0.75971795
80MP0004484_altered_response_of0.75624308
81MP0008961_abnormal_basal_metabolism0.75429526
82MP0004142_abnormal_muscle_tone0.74390756
83MP0002138_abnormal_hepatobiliary_system0.71633100
84MP0000778_abnormal_nervous_system0.70187496
85MP0001986_abnormal_taste_sensitivity0.69742686
86MP0003137_abnormal_impulse_conducting0.67513941
87MP0003632_abnormal_nervous_system0.66287133
88MP0000534_abnormal_ureter_morphology0.65482368
89MP0005083_abnormal_biliary_tract0.64762234
90MP0005623_abnormal_meninges_morphology0.64025205
91MP0002752_abnormal_somatic_nervous0.63964252
92MP0004233_abnormal_muscle_weight0.59766167
93MP0002069_abnormal_eating/drinking_beha0.59566270
94MP0001270_distended_abdomen0.58059785
95MP0002269_muscular_atrophy0.58040459
96MP0000003_abnormal_adipose_tissue0.56648125
97MP0002066_abnormal_motor_capabilities/c0.56589322
98MP0001502_abnormal_circadian_rhythm0.56236091
99MP0008995_early_reproductive_senescence0.56039135
100MP0000733_abnormal_muscle_development0.56026021

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)6.57763054
2Tubulointerstitial nephritis (HP:0001970)5.27522502
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.00857000
4Absent/shortened dynein arms (HP:0200106)5.00857000
5Hypoplastic ischia (HP:0003175)4.70107052
6Bony spicule pigmentary retinopathy (HP:0007737)4.68510757
7Attenuation of retinal blood vessels (HP:0007843)4.51539103
8Abnormal ciliary motility (HP:0012262)4.43843151
9Chronic hepatic failure (HP:0100626)4.30876789
10Progressive cerebellar ataxia (HP:0002073)4.22552301
11Abnormality of the ischium (HP:0003174)4.13654829
12Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.03633129
13Abnormal respiratory motile cilium physiology (HP:0012261)4.01703041
14Abnormal respiratory epithelium morphology (HP:0012253)3.98838812
15Abnormal respiratory motile cilium morphology (HP:0005938)3.98838812
16Asymmetric septal hypertrophy (HP:0001670)3.80605420
17Nasal polyposis (HP:0100582)3.77738288
18Bell-shaped thorax (HP:0001591)3.73869058
19Resting tremor (HP:0002322)3.70948723
20Abnormality of macular pigmentation (HP:0008002)3.60020130
21Hyperkalemia (HP:0002153)3.56399952
22Abnormal rod and cone electroretinograms (HP:0008323)3.52545578
23Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.45571583
24Aplasia/Hypoplasia of the earlobes (HP:0009906)3.44841883
25Postural instability (HP:0002172)3.38761818
26Potter facies (HP:0002009)3.34212024
27Facial shape deformation (HP:0011334)3.34212024
28Infertility (HP:0000789)3.30377976
29Enlarged epiphyses (HP:0010580)3.19141416
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.16493627
31Male infertility (HP:0003251)3.15367977
32Myokymia (HP:0002411)3.15193753
33Abnormality of the nasal mucosa (HP:0000433)3.10794991
34Cone-rod dystrophy (HP:0000548)3.04977505
35Azoospermia (HP:0000027)3.02052808
36Double outlet right ventricle (HP:0001719)3.01393271
37Congenital malformation of the right heart (HP:0011723)3.01393271
38Nephronophthisis (HP:0000090)2.98398308
39Impulsivity (HP:0100710)2.93780747
40Atonic seizures (HP:0010819)2.77520361
41Abnormality of the pubic bones (HP:0003172)2.75879184
42Tubulointerstitial abnormality (HP:0001969)2.75225296
43Progressive sensorineural hearing impairment (HP:0000408)2.53984037
44Failure to thrive in infancy (HP:0001531)2.51988746
45Abnormality of the renal medulla (HP:0100957)2.50779653
46Truncal obesity (HP:0001956)2.50017060
47Focal motor seizures (HP:0011153)2.47709955
48Stage 5 chronic kidney disease (HP:0003774)2.42497095
49Abnormal spermatogenesis (HP:0008669)2.41820258
50Action tremor (HP:0002345)2.40816458
51Abnormality of the aortic arch (HP:0012303)2.33738160
52Rhinitis (HP:0012384)2.33660366
53Hyperthyroidism (HP:0000836)2.30749593
54Abnormality of the parathyroid morphology (HP:0011766)2.29174083
55Recurrent corneal erosions (HP:0000495)2.24707022
56Flattened epiphyses (HP:0003071)2.24328993
57Unilateral renal agenesis (HP:0000122)2.23662731
58Genetic anticipation (HP:0003743)2.20467403
59Abnormal urine output (HP:0012590)2.19792388
60Renal dysplasia (HP:0000110)2.17468374
61Amelogenesis imperfecta (HP:0000705)2.16866372
62Abnormality of dental color (HP:0011073)2.14736365
63Peripheral hypomyelination (HP:0007182)2.13904779
64Amblyopia (HP:0000646)2.10945992
65Insulin-resistant diabetes mellitus (HP:0000831)2.10017736
66Abnormality of potassium homeostasis (HP:0011042)2.08393235
67Generalized aminoaciduria (HP:0002909)2.07545350
68Hypoplasia of the thymus (HP:0000778)2.02164853
69Febrile seizures (HP:0002373)2.01377883
70Upper limb muscle weakness (HP:0003484)2.01034165
71Renovascular hypertension (HP:0100817)1.99133910
72Truncus arteriosus (HP:0001660)1.97183424
73Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.96006642
74Absent epiphyses (HP:0010577)1.96006642
75Bowel incontinence (HP:0002607)1.94837111
76Optic nerve hypoplasia (HP:0000609)1.92905838
77Abdominal situs inversus (HP:0003363)1.88722303
78Abnormality of abdominal situs (HP:0011620)1.88722303
79Hemiparesis (HP:0001269)1.88601567
80Polyuria (HP:0000103)1.88595975
81Ventricular tachycardia (HP:0004756)1.87343239
82Abnormality of the epiphysis of the femoral head (HP:0010574)1.86971559
83Hypoalphalipoproteinemia (HP:0003233)1.80245483
84Congenital sensorineural hearing impairment (HP:0008527)1.80057567
85Portal hypertension (HP:0001409)1.78795396
86Focal segmental glomerulosclerosis (HP:0000097)1.78716526
87Polydipsia (HP:0001959)1.78162506
88Abnormal drinking behavior (HP:0030082)1.78162506
89Epiphyseal dysplasia (HP:0002656)1.77442181
90Retinal dysplasia (HP:0007973)1.75906977
91Abnormality of renal excretion (HP:0011036)1.75785719
92Decreased central vision (HP:0007663)1.75538611
93Atelectasis (HP:0100750)1.74388203
94Gaze-evoked nystagmus (HP:0000640)1.73574149
95Primary atrial arrhythmia (HP:0001692)1.73505119
96Atrial fibrillation (HP:0005110)1.72229873
97Osteomalacia (HP:0002749)1.72208721
98Ulnar claw (HP:0001178)1.71162661
99Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.70582256
100Abnormality of femoral epiphyses (HP:0006499)1.70582256

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK45.86023852
2TESK14.39730263
3DDR23.92614646
4STK383.60599785
5MAP4K23.56359453
6INSRR3.27394103
7BRD43.24632751
8STK38L3.06566163
9PLK22.42243117
10MAPK152.03012593
11ICK1.95713337
12PINK11.95592209
13MARK11.93549964
14CAMK1G1.92359700
15KSR21.70774541
16PTK2B1.59039297
17PNCK1.55365720
18MAP2K71.51405927
19NTRK31.50783180
20PDK11.40139899
21PRKD31.39230158
22MAP3K41.39060843
23SIK21.38831728
24PDPK11.36234981
25FRK1.32602435
26MAP3K91.32190537
27DYRK1B1.27466274
28FGFR21.19920220
29MST1R1.17218003
30AKT31.11133478
31ARAF1.10989238
32PIK3CG1.08840409
33CDK121.05889545
34CAMK1D1.01762933
35WNK11.01698638
36CAMK10.91881465
37LATS10.91329276
38NEK60.90619098
39CAMKK20.88237874
40CAMK40.85775962
41BRAF0.85514498
42JAK30.85462907
43MAP3K20.84061833
44CDK30.82819672
45BMPR1B0.82311711
46CDK70.81536344
47RPS6KA20.75114640
48PRKG10.74503167
49SGK4940.72332501
50SGK2230.72332501
51MARK20.71652451
52DAPK20.68445787
53UHMK10.67183178
54PKN10.62744555
55NTRK20.61563443
56TIE10.60664749
57ZAK0.59567938
58LATS20.58304834
59PRKCZ0.57292603
60RET0.55304618
61RPS6KA10.54785673
62MAP3K130.54029430
63MAPK130.51241482
64PRKCG0.50686103
65PRKAA20.49993051
66MAP3K70.49345158
67CDK50.47318257
68PRKAA10.46226043
69MINK10.45633101
70PHKG20.45257192
71PHKG10.45257192
72MET0.44789229
73CAMK2A0.44397137
74ROCK10.42379849
75RPS6KA60.39981024
76GSK3B0.39448970
77OBSCN0.39320742
78CAMKK10.38953779
79EPHA40.38253968
80MAP2K40.37306143
81MAPK10.36781877
82ADRBK20.36578921
83PRKG20.36208057
84WNK30.36187751
85MAPK80.32603213
86MUSK0.32307925
87DYRK20.30805579
88TYRO30.30404119
89SGK10.29654221
90MAPK110.29471194
91PAK60.29092014
92RPS6KL10.28518483
93RPS6KC10.28518483
94CDK10.28144533
95CDK20.28076221
96PRKCB0.27378391
97TNK20.27289687
98SGK20.26936630
99RPS6KA30.25803474
100DYRK30.25182031

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.72509374
2Olfactory transduction_Homo sapiens_hsa047403.74936917
3Fatty acid biosynthesis_Homo sapiens_hsa000613.63781672
4Nicotine addiction_Homo sapiens_hsa050332.72774507
5Butanoate metabolism_Homo sapiens_hsa006502.66375953
6Taste transduction_Homo sapiens_hsa047422.32019280
7Morphine addiction_Homo sapiens_hsa050322.12603118
8Dorso-ventral axis formation_Homo sapiens_hsa043201.93598766
9GABAergic synapse_Homo sapiens_hsa047271.90239003
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.85839275
11Circadian entrainment_Homo sapiens_hsa047131.82185125
12Synaptic vesicle cycle_Homo sapiens_hsa047211.79726505
13Glycerophospholipid metabolism_Homo sapiens_hsa005641.79717989
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77918101
15Glutamatergic synapse_Homo sapiens_hsa047241.72665143
16Type II diabetes mellitus_Homo sapiens_hsa049301.62149164
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45080558
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37871019
19Type I diabetes mellitus_Homo sapiens_hsa049401.36602297
20Calcium signaling pathway_Homo sapiens_hsa040201.36223883
21Salivary secretion_Homo sapiens_hsa049701.31430785
22Phototransduction_Homo sapiens_hsa047441.30466010
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22942979
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20937852
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19969807
26Oocyte meiosis_Homo sapiens_hsa041141.15577553
27cAMP signaling pathway_Homo sapiens_hsa040241.12112997
28Phenylalanine metabolism_Homo sapiens_hsa003601.11556065
29Autoimmune thyroid disease_Homo sapiens_hsa053201.11196452
30Insulin secretion_Homo sapiens_hsa049111.10480717
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04962086
32Allograft rejection_Homo sapiens_hsa053301.04942191
33Nitrogen metabolism_Homo sapiens_hsa009101.03455429
34ABC transporters_Homo sapiens_hsa020101.02866299
35Long-term potentiation_Homo sapiens_hsa047201.02239181
36Arginine and proline metabolism_Homo sapiens_hsa003301.01835213
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00552653
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00338425
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96271488
40Serotonergic synapse_Homo sapiens_hsa047260.93820520
41Graft-versus-host disease_Homo sapiens_hsa053320.93640120
42Gastric acid secretion_Homo sapiens_hsa049710.93637661
43Cholinergic synapse_Homo sapiens_hsa047250.90719334
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90515501
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86996985
46Oxytocin signaling pathway_Homo sapiens_hsa049210.83939069
47Dopaminergic synapse_Homo sapiens_hsa047280.82636071
48Viral myocarditis_Homo sapiens_hsa054160.82441979
49Alcoholism_Homo sapiens_hsa050340.82168696
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.81659442
51Long-term depression_Homo sapiens_hsa047300.80666192
52Inositol phosphate metabolism_Homo sapiens_hsa005620.78364759
53Linoleic acid metabolism_Homo sapiens_hsa005910.77922878
54MAPK signaling pathway_Homo sapiens_hsa040100.75478720
55Amphetamine addiction_Homo sapiens_hsa050310.73209531
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71758113
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71335024
58Cocaine addiction_Homo sapiens_hsa050300.70477881
59Estrogen signaling pathway_Homo sapiens_hsa049150.69116353
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68692860
61Renin secretion_Homo sapiens_hsa049240.68599445
62Arginine biosynthesis_Homo sapiens_hsa002200.68503276
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67884972
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.65285633
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63999748
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61408038
67Endocytosis_Homo sapiens_hsa041440.60494525
68Antigen processing and presentation_Homo sapiens_hsa046120.59587983
69Protein digestion and absorption_Homo sapiens_hsa049740.57943565
70Gap junction_Homo sapiens_hsa045400.57758180
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57027835
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53605548
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53104686
74Cardiac muscle contraction_Homo sapiens_hsa042600.52443849
75Fatty acid metabolism_Homo sapiens_hsa012120.51346395
76Basal transcription factors_Homo sapiens_hsa030220.49680257
77Selenocompound metabolism_Homo sapiens_hsa004500.48863316
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.48126789
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48113583
80Circadian rhythm_Homo sapiens_hsa047100.47942453
81Fatty acid degradation_Homo sapiens_hsa000710.45033398
82PPAR signaling pathway_Homo sapiens_hsa033200.43583488
83Tyrosine metabolism_Homo sapiens_hsa003500.42432312
84Choline metabolism in cancer_Homo sapiens_hsa052310.42109595
85Pancreatic secretion_Homo sapiens_hsa049720.40121965
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39510858
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38365109
88Ether lipid metabolism_Homo sapiens_hsa005650.37564041
89Hedgehog signaling pathway_Homo sapiens_hsa043400.37041444
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36669790
91Systemic lupus erythematosus_Homo sapiens_hsa053220.35892717
92mTOR signaling pathway_Homo sapiens_hsa041500.35018860
93Glycerolipid metabolism_Homo sapiens_hsa005610.34317851
94Purine metabolism_Homo sapiens_hsa002300.34090560
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.33778991
96Bile secretion_Homo sapiens_hsa049760.33518568
97Melanoma_Homo sapiens_hsa052180.33506514
98Ovarian steroidogenesis_Homo sapiens_hsa049130.31529263
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.30384190
100VEGF signaling pathway_Homo sapiens_hsa043700.30136973

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