ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	gamma-aminobutyric acid transport (GO:0015812)	7.20646290
2	phosphorelay signal transduction system (GO:0000160)	5.67329605
3	response to pheromone (GO:0019236)	5.46722257
4	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.98039626
5	acrosome reaction (GO:0007340)	4.89199321
6	somite rostral/caudal axis specification (GO:0032525)	4.59645750
7	synaptic vesicle exocytosis (GO:0016079)	4.53365480
8	pyrimidine nucleobase catabolic process (GO:0006208)	4.45553795
9	neurotransmitter-gated ion channel clustering (GO:0072578)	4.41399918
10	neuronal action potential propagation (GO:0019227)	4.38023458
11	glycine transport (GO:0015816)	4.37383618
12	synaptic vesicle maturation (GO:0016188)	4.16009126
13	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	4.15249185
14	protein localization to synapse (GO:0035418)	3.91291413
15	protein targeting to Golgi (GO:0000042)	3.90004877
16	sleep (GO:0030431)	3.86986271
17	establishment of protein localization to Golgi (GO:0072600)	3.86861661
18	sperm motility (GO:0030317)	3.83107518
19	neuron cell-cell adhesion (GO:0007158)	3.81124963
20	neurotransmitter secretion (GO:0007269)	3.75249301
21	nucleobase catabolic process (GO:0046113)	3.72218767
22	calcium ion-dependent exocytosis (GO:0017156)	3.71570476
23	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.61078181
24	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.60840272
25	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.60529111
26	spermatid nucleus differentiation (GO:0007289)	3.55515189
27	synaptic transmission, cholinergic (GO:0007271)	3.49662239
28	retinal cone cell development (GO:0046549)	3.47926225
29	protein polyglutamylation (GO:0018095)	3.47357071
30	multicellular organism reproduction (GO:0032504)	3.47127390
31	membrane depolarization during action potential (GO:0086010)	3.46533336
32	righting reflex (GO:0060013)	3.32203885
33	glycosphingolipid biosynthetic process (GO:0006688)	3.31330087
34	neurotransmitter biosynthetic process (GO:0042136)	3.26797631
35	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.26552331
36	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	3.24088870
37	sialylation (GO:0097503)	3.22149702
38	neuromuscular synaptic transmission (GO:0007274)	3.19126701
39	establishment of mitochondrion localization (GO:0051654)	3.18428886
40	sperm capacitation (GO:0048240)	3.17310487
41	microtubule depolymerization (GO:0007019)	3.16712297
42	regulation of neurotransmitter levels (GO:0001505)	3.15051549
43	vocalization behavior (GO:0071625)	3.14851757
44	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.12134109
45	proline transport (GO:0015824)	3.10913078
46	protein localization to Golgi apparatus (GO:0034067)	3.06976419
47	neuronal ion channel clustering (GO:0045161)	3.06959283
48	startle response (GO:0001964)	3.04513960
49	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.02288017
50	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.01091511
51	protein insertion into membrane (GO:0051205)	3.00130418
52	response to histamine (GO:0034776)	2.97799487
53	cochlea development (GO:0090102)	2.96895465
54	neurotransmitter metabolic process (GO:0042133)	2.96404937
55	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.95705639
56	neurotransmitter transport (GO:0006836)	2.93635317
57	neuronal action potential (GO:0019228)	2.92842729
58	glutamate secretion (GO:0014047)	2.92634615
59	neuron-neuron synaptic transmission (GO:0007270)	2.89601155
60	postsynaptic membrane organization (GO:0001941)	2.88004680
61	microtubule severing (GO:0051013)	2.85603196
62	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.82253858
63	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.81925576
64	reproduction (GO:0000003)	2.80876266
65	dendrite morphogenesis (GO:0048813)	2.79549360
66	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.78855126
67	inner ear receptor cell development (GO:0060119)	2.76857777
68	transmission of nerve impulse (GO:0019226)	2.76711734
69	glutamate receptor signaling pathway (GO:0007215)	2.75766373
70	positive regulation of amino acid transport (GO:0051957)	2.75574032
71	synaptic transmission, glutamatergic (GO:0035249)	2.74329718
72	neuron recognition (GO:0008038)	2.74168309
73	piRNA metabolic process (GO:0034587)	2.72390050
74	microtubule polymerization or depolymerization (GO:0031109)	2.72186559
75	urinary tract smooth muscle contraction (GO:0014848)	2.72143235
76	regulation of synaptic transmission, GABAergic (GO:0032228)	2.71243357
77	male meiosis (GO:0007140)	2.70907192
78	alanine transport (GO:0032328)	2.65142279
79	RNA localization (GO:0006403)	2.64739889
80	regulation of microtubule-based movement (GO:0060632)	2.63116731
81	negative regulation of interleukin-10 production (GO:0032693)	2.62962491
82	epithelial cilium movement (GO:0003351)	2.62285246
83	cerebral cortex neuron differentiation (GO:0021895)	2.60478645
84	cAMP catabolic process (GO:0006198)	2.60280124
85	fusion of sperm to egg plasma membrane (GO:0007342)	2.59898900
86	behavioral response to nicotine (GO:0035095)	2.59644362
87	regulation of synaptic vesicle exocytosis (GO:2000300)	2.57450959
88	axonal fasciculation (GO:0007413)	2.55935038
89	sperm-egg recognition (GO:0035036)	2.55438108
90	regulation of female receptivity (GO:0045924)	2.55358372
91	reflex (GO:0060004)	2.54903377
92	regulation of transcription involved in cell fate commitment (GO:0060850)	2.54098815
93	single fertilization (GO:0007338)	2.53930827
94	RNA destabilization (GO:0050779)	2.52939615
95	dendritic spine organization (GO:0097061)	2.52230269
96	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.51699764
97	regulation of cilium movement (GO:0003352)	2.51694995
98	detection of calcium ion (GO:0005513)	2.50419318
99	regulation of chemokine-mediated signaling pathway (GO:0070099)	2.49867371
100	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.49370686

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.03458181
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.55459857
3	TAF15_26573619_Chip-Seq_HEK293_Human	2.43088736
4	DROSHA_22980978_ChIP-Seq_HELA_Human	2.41363762
5	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.33648618
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.32163689
7	REST_21632747_ChIP-Seq_MESCs_Mouse	2.31422386
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.30281244
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.28678320
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.19431853
11	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.08715650
12	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.06892332
13	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.06867188
14	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.91842449
15	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.90312563
16	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.88259135
17	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.86647202
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.85199146
19	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.80015923
20	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.79806149
21	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.79299601
22	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.78169334
23	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.75412879
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.69082948
25	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.67877825
26	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.63725546
27	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.63464771
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63307345
29	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.63003713
30	AR_25329375_ChIP-Seq_VCAP_Human	1.62726499
31	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.55260496
32	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.53832665
33	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.52733342
34	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.52733342
35	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.52631061
36	STAT3_23295773_ChIP-Seq_U87_Human	1.52120489
37	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.52102123
38	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.51769083
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.51269372
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.50594724
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50594724
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.44572591
43	AR_21572438_ChIP-Seq_LNCaP_Human	1.43197153
44	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.42683467
45	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.42615384
46	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.42177999
47	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41330312
48	P300_19829295_ChIP-Seq_ESCs_Human	1.41118938
49	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.40006303
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38153658
51	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.37896686
52	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.35468932
53	FUS_26573619_Chip-Seq_HEK293_Human	1.34006949
54	IGF1R_20145208_ChIP-Seq_DFB_Human	1.29020138
55	TCF4_23295773_ChIP-Seq_U87_Human	1.26525714
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.24876930
57	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24876930
58	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.24090753
59	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19271352
60	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16403852
61	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14571322
62	AR_19668381_ChIP-Seq_PC3_Human	1.14307965
63	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.13071585
64	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.09898026
65	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09631471
66	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09369520
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08932079
68	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.07596847
69	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.05931154
70	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.05883095
71	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03103218
72	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.02138973
73	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01975695
74	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01975695
75	RNF2_27304074_Chip-Seq_NSC_Mouse	1.01889686
76	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.01259202
77	MYC_19829295_ChIP-Seq_ESCs_Human	1.00740718
78	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.97825052
79	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.97490096
80	ERA_21632823_ChIP-Seq_H3396_Human	0.96763761
81	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96179104
82	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.96095838
83	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.95690711
84	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.95555746
85	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.94370796
86	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.94137614
87	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.93335693
88	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.93317511
89	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.93247078
90	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.92801199
91	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.92713562
92	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.92688990
93	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.89757048
94	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.89665418
95	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.89594620
96	TBL1_22424771_ChIP-Seq_293T_Human	0.89113615
97	AHR_22903824_ChIP-Seq_MCF-7_Human	0.88327172
98	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.87998956
99	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.87561334
100	TP53_18474530_ChIP-ChIP_U2OS_Human	0.86986950

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	3.75578084
2	MP0004270_analgesia	3.60605820
3	MP0005410_abnormal_fertilization	3.01796705
4	MP0003635_abnormal_synaptic_transmissio	2.93394640
5	MP0001486_abnormal_startle_reflex	2.70810006
6	MP0009745_abnormal_behavioral_response	2.64735266
7	MP0002272_abnormal_nervous_system	2.60564269
8	MP0005423_abnormal_somatic_nervous	2.57158827
9	MP0001986_abnormal_taste_sensitivity	2.50661002
10	MP0001968_abnormal_touch/_nociception	2.47022125
11	MP0001529_abnormal_vocalization	2.46144914
12	MP0003879_abnormal_hair_cell	2.44407401
13	MP0002064_seizures	2.40797710
14	MP0005377_hearing/vestibular/ear_phenot	2.40360429
15	MP0003878_abnormal_ear_physiology	2.40360429
16	MP0001501_abnormal_sleep_pattern	2.37861155
17	MP0002063_abnormal_learning/memory/cond	2.17148101
18	MP0003880_abnormal_central_pattern	2.13161230
19	MP0002572_abnormal_emotion/affect_behav	2.08092088
20	MP0009046_muscle_twitch	2.06552972
21	MP0002735_abnormal_chemical_nociception	2.04309458
22	MP0008961_abnormal_basal_metabolism	1.94321420
23	MP0002734_abnormal_mechanical_nocicepti	1.91220085
24	MP0004142_abnormal_muscle_tone	1.86662829
25	MP0008877_abnormal_DNA_methylation	1.86266510
26	MP0002067_abnormal_sensory_capabilities	1.82697302
27	MP0004147_increased_porphyrin_level	1.81730353
28	MP0005670_abnormal_white_adipose	1.80263356
29	MP0002557_abnormal_social/conspecific_i	1.76732847
30	MP0002736_abnormal_nociception_after	1.72805663
31	MP0002653_abnormal_ependyma_morphology	1.65762782
32	MP0004043_abnormal_pH_regulation	1.64115318
33	MP0005394_taste/olfaction_phenotype	1.59290934
34	MP0005499_abnormal_olfactory_system	1.59290934
35	MP0006276_abnormal_autonomic_nervous	1.57698070
36	MP0002733_abnormal_thermal_nociception	1.57491670
37	MP0009780_abnormal_chondrocyte_physiolo	1.54431926
38	MP0001984_abnormal_olfaction	1.52959887
39	MP0001970_abnormal_pain_threshold	1.52682239
40	MP0008789_abnormal_olfactory_epithelium	1.49156088
41	MP0004811_abnormal_neuron_physiology	1.44900525
42	MP0005084_abnormal_gallbladder_morpholo	1.43171556
43	MP0000955_abnormal_spinal_cord	1.42661534
44	MP0003698_abnormal_male_reproductive	1.40754109
45	MP0001440_abnormal_grooming_behavior	1.39754111
46	MP0005623_abnormal_meninges_morphology	1.36714024
47	MP0008569_lethality_at_weaning	1.31901068
48	MP0002184_abnormal_innervation	1.29568863
49	MP0002882_abnormal_neuron_morphology	1.23879039
50	MP0004924_abnormal_behavior	1.23807515
51	MP0005386_behavior/neurological_phenoty	1.23807515
52	MP0000778_abnormal_nervous_system	1.21343161
53	MP0005551_abnormal_eye_electrophysiolog	1.20655805
54	MP0001177_atelectasis	1.19832543
55	MP0003329_amyloid_beta_deposits	1.18762645
56	MP0002909_abnormal_adrenal_gland	1.17150264
57	MP0000372_irregular_coat_pigmentation	1.15795873
58	MP0008872_abnormal_physiological_respon	1.14465875
59	MP0002876_abnormal_thyroid_physiology	1.14421180
60	MP0003646_muscle_fatigue	1.12650994
61	MP0001188_hyperpigmentation	1.11121383
62	MP0004134_abnormal_chest_morphology	1.09847284
63	MP0002249_abnormal_larynx_morphology	1.09059229
64	MP0002066_abnormal_motor_capabilities/c	1.09018023
65	MP0001502_abnormal_circadian_rhythm	1.08630986
66	MP0005645_abnormal_hypothalamus_physiol	1.08209761
67	MP0003718_maternal_effect	1.06749896
68	MP0006292_abnormal_olfactory_placode	1.05104072
69	MP0000026_abnormal_inner_ear	1.04632819
70	MP0004885_abnormal_endolymph	1.04082250
71	MP0001929_abnormal_gametogenesis	1.03293065
72	MP0001963_abnormal_hearing_physiology	1.03051295
73	MP0002277_abnormal_respiratory_mucosa	1.01814382
74	MP0002822_catalepsy	0.98624059
75	MP0003633_abnormal_nervous_system	0.98623646
76	MP0004742_abnormal_vestibular_system	0.98509404
77	MP0003938_abnormal_ear_development	0.97812387
78	MP0002229_neurodegeneration	0.93582380
79	MP0004233_abnormal_muscle_weight	0.90523051
80	MP0002752_abnormal_somatic_nervous	0.89838887
81	MP0002132_abnormal_respiratory_system	0.87049271
82	MP0001485_abnormal_pinna_reflex	0.86182696
83	MP0001879_abnormal_lymphatic_vessel	0.86013991
84	MP0010386_abnormal_urinary_bladder	0.85797671
85	MP0001905_abnormal_dopamine_level	0.85465134
86	MP0002069_abnormal_eating/drinking_beha	0.84034560
87	MP0000049_abnormal_middle_ear	0.83999482
88	MP0003631_nervous_system_phenotype	0.82980559
89	MP0000733_abnormal_muscle_development	0.81364817
90	MP0004133_heterotaxia	0.80894528
91	MP0000631_abnormal_neuroendocrine_gland	0.80467770
92	MP0002161_abnormal_fertility/fecundity	0.79189054
93	MP0004085_abnormal_heartbeat	0.78789513
94	MP0001270_distended_abdomen	0.78479082
95	MP0003137_abnormal_impulse_conducting	0.76917846
96	MP0003122_maternal_imprinting	0.73988866
97	MP0002152_abnormal_brain_morphology	0.72074865
98	MP0000013_abnormal_adipose_tissue	0.71968635
99	MP0003183_abnormal_peptide_metabolism	0.71312244
100	MP0001348_abnormal_lacrimal_gland	0.69755173

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Atonic seizures (HP:0010819)	4.95455759
2	Focal motor seizures (HP:0011153)	4.91315568
3	Progressive cerebellar ataxia (HP:0002073)	4.42471835
4	Ankle clonus (HP:0011448)	4.13151529
5	Myokymia (HP:0002411)	3.90229919
6	Action tremor (HP:0002345)	3.90219921
7	Spastic gait (HP:0002064)	3.82212636
8	Febrile seizures (HP:0002373)	3.70805968
9	Urinary urgency (HP:0000012)	3.66102524
10	Drooling (HP:0002307)	3.63711278
11	Genetic anticipation (HP:0003743)	3.62331407
12	Excessive salivation (HP:0003781)	3.39204306
13	Hemiparesis (HP:0001269)	3.36513806
14	Focal seizures (HP:0007359)	3.30511123
15	Supranuclear gaze palsy (HP:0000605)	3.10594856
16	Dialeptic seizures (HP:0011146)	3.05174082
17	Failure to thrive in infancy (HP:0001531)	2.97176632
18	Absence seizures (HP:0002121)	2.95658286
19	Dysdiadochokinesis (HP:0002075)	2.88806698
20	Split foot (HP:0001839)	2.88116642
21	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.84333730
22	Absent/shortened dynein arms (HP:0200106)	2.84333730
23	Epileptic encephalopathy (HP:0200134)	2.82753664
24	Epileptiform EEG discharges (HP:0011182)	2.80614624
25	Generalized tonic-clonic seizures (HP:0002069)	2.77564841
26	Hypsarrhythmia (HP:0002521)	2.72410828
27	EEG with generalized epileptiform discharges (HP:0011198)	2.71143866
28	Lower limb muscle weakness (HP:0007340)	2.65439200
29	Dysmetria (HP:0001310)	2.56846816
30	Pendular nystagmus (HP:0012043)	2.51946542
31	Poor eye contact (HP:0000817)	2.48027584
32	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.45661823
33	Absent speech (HP:0001344)	2.43658615
34	Lissencephaly (HP:0001339)	2.43538438
35	Abnormal ciliary motility (HP:0012262)	2.41499131
36	Hyperglycinemia (HP:0002154)	2.39895386
37	Prominent supraorbital ridges (HP:0000336)	2.37554836
38	Neurofibrillary tangles (HP:0002185)	2.36163576
39	Urinary bladder sphincter dysfunction (HP:0002839)	2.32458239
40	Clonus (HP:0002169)	2.31004742
41	Papillary thyroid carcinoma (HP:0002895)	2.26754343
42	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.23719850
43	Hypoplasia of the brainstem (HP:0002365)	2.23719850
44	Polyphagia (HP:0002591)	2.23286163
45	Abnormal respiratory motile cilium morphology (HP:0005938)	2.21147362
46	Abnormal respiratory epithelium morphology (HP:0012253)	2.21147362
47	Chronic hepatic failure (HP:0100626)	2.20849951
48	Esotropia (HP:0000565)	2.18786554
49	Truncal obesity (HP:0001956)	2.16135655
50	Severe visual impairment (HP:0001141)	2.15303917
51	Delusions (HP:0000746)	2.14117596
52	Abnormality of the pubic bones (HP:0003172)	2.13214237
53	Neoplasm of the heart (HP:0100544)	2.11268097
54	Tubulointerstitial nephritis (HP:0001970)	2.08854226
55	Abnormality of dental color (HP:0011073)	2.08765901
56	Gaze-evoked nystagmus (HP:0000640)	2.05041295
57	Optic nerve hypoplasia (HP:0000609)	2.04788089
58	Postural instability (HP:0002172)	2.04328862
59	Unilateral renal agenesis (HP:0000122)	2.03945874
60	Abnormal respiratory motile cilium physiology (HP:0012261)	2.03274397
61	Global brain atrophy (HP:0002283)	2.00195369
62	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.98930756
63	Hyperventilation (HP:0002883)	1.98855521
64	Type II lissencephaly (HP:0007260)	1.97621415
65	Spastic paraplegia (HP:0001258)	1.96854535
66	Opisthotonus (HP:0002179)	1.96779669
67	Bony spicule pigmentary retinopathy (HP:0007737)	1.95472428
68	Abnormality of binocular vision (HP:0011514)	1.90231558
69	Diplopia (HP:0000651)	1.90231558
70	Status epilepticus (HP:0002133)	1.89741573
71	Renal Fanconi syndrome (HP:0001994)	1.89563955
72	Amyotrophic lateral sclerosis (HP:0007354)	1.88700573
73	Congenital stationary night blindness (HP:0007642)	1.88615170
74	Gait imbalance (HP:0002141)	1.88310870
75	Paraplegia (HP:0010550)	1.88223848
76	Thyroid-stimulating hormone excess (HP:0002925)	1.87919471
77	Visual hallucinations (HP:0002367)	1.87349916
78	Mutism (HP:0002300)	1.85547123
79	Cerebral inclusion bodies (HP:0100314)	1.81254178
80	Methylmalonic acidemia (HP:0002912)	1.81244254
81	Nephronophthisis (HP:0000090)	1.81038205
82	Abnormal eating behavior (HP:0100738)	1.80983493
83	Cerebellar dysplasia (HP:0007033)	1.80672228
84	Enlarged epiphyses (HP:0010580)	1.80417682
85	Limb dystonia (HP:0002451)	1.79134613
86	Inability to walk (HP:0002540)	1.78549298
87	Exertional dyspnea (HP:0002875)	1.77977926
88	Protruding tongue (HP:0010808)	1.76028522
89	Glycosuria (HP:0003076)	1.75885542
90	Abnormality of urine glucose concentration (HP:0011016)	1.75885542
91	Impaired smooth pursuit (HP:0007772)	1.74854580
92	Abnormality of salivation (HP:0100755)	1.74765196
93	Impaired social interactions (HP:0000735)	1.74427826
94	Abnormal social behavior (HP:0012433)	1.74427826
95	Spastic tetraplegia (HP:0002510)	1.72231533
96	Infertility (HP:0000789)	1.71502552
97	Retinal dysplasia (HP:0007973)	1.71486053
98	Intention tremor (HP:0002080)	1.71321527
99	Rhinitis (HP:0012384)	1.70645760
100	Lower limb hyperreflexia (HP:0002395)	1.70197880

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	4.29491252
2	MAP3K6	3.86497501
3	MAP3K9	3.28186123
4	MAP3K4	3.06008320
5	ARAF	3.05319221
6	TESK1	2.50413418
7	BRD4	2.48020826
8	MAP4K2	2.39350540
9	MAP2K7	2.31108839
10	NTRK2	2.23483484
11	INSRR	2.20680339
12	PINK1	2.16488968
13	NTRK3	1.91520445
14	KSR2	1.80071862
15	CASK	1.72468967
16	RAF1	1.62447196
17	MAPK13	1.62082775
18	BCKDK	1.60224354
19	TAOK1	1.52845448
20	MAP3K13	1.46586456
21	ERBB3	1.41803075
22	MARK2	1.39893498
23	PLK2	1.37420692
24	STK38	1.36344383
25	MAP2K4	1.33541577
26	STK38L	1.32811737
27	GRK6	1.30934203
28	TLK1	1.29594896
29	PRKCG	1.18985842
30	DAPK2	1.13163107
31	ICK	1.11800555
32	ADRBK2	1.05996447
33	SIK2	1.00225501
34	WNK3	0.97693434
35	WNK1	0.97418206
36	TAOK3	0.96632664
37	PHKG1	0.94551645
38	PHKG2	0.94551645
39	BRAF	0.94226611
40	PKN1	0.92153889
41	NEK6	0.91183385
42	EPHA4	0.88387725
43	PRKCE	0.88007137
44	PAK6	0.87819238
45	PAK3	0.87177623
46	MAP3K14	0.86787064
47	UHMK1	0.82674664
48	EPHA3	0.82620743
49	RPS6KA2	0.77830166
50	CSNK1G2	0.77123263
51	MAP2K6	0.76961339
52	MAPK15	0.76029682
53	FGFR2	0.75996038
54	CDK5	0.75470736
55	MINK1	0.75172865
56	RET	0.74530744
57	TESK2	0.74132487
58	CAMK2A	0.73846837
59	TNIK	0.72870373
60	DYRK2	0.72274793
61	DDR2	0.70001562
62	RPS6KA4	0.69395308
63	AKT3	0.68693197
64	PIK3CG	0.68544949
65	PRKCZ	0.65793371
66	LIMK1	0.64581488
67	CSNK1G3	0.64090170
68	MUSK	0.62466550
69	GRK1	0.59944671
70	CSNK1A1L	0.59198334
71	ZAK	0.58366804
72	CDK3	0.57300805
73	CAMK1	0.56867739
74	KSR1	0.55258836
75	TRIM28	0.54463960
76	DAPK1	0.53546940
77	PRKAA1	0.50727506
78	CAMK4	0.50312310
79	PDK1	0.50182781
80	RPS6KA3	0.49754037
81	PRKACA	0.49247358
82	PRKACB	0.46131487
83	PRKG1	0.45388379
84	CAMK2B	0.44082062
85	PRKCB	0.43823650
86	GRK5	0.41902993
87	PLK4	0.40959887
88	MAP3K7	0.39543637
89	PRKCA	0.38813955
90	CSNK1G1	0.38800464
91	PDPK1	0.36899876
92	PRKCQ	0.34987200
93	CAMKK1	0.34605215
94	FRK	0.32937131
95	SGK223	0.31900406
96	SGK494	0.31900406
97	PRKCI	0.30702821
98	PRKD2	0.30677537
99	CSNK1D	0.30664147
100	GSK3B	0.30320431

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.95342273
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.59955131
3	GABAergic synapse_Homo sapiens_hsa04727	3.59421320
4	Morphine addiction_Homo sapiens_hsa05032	3.11114008
5	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.94495473
6	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.55504478
7	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.52140134
8	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.34945051
9	Circadian entrainment_Homo sapiens_hsa04713	2.25564563
10	Taste transduction_Homo sapiens_hsa04742	2.14618186
11	Glutamatergic synapse_Homo sapiens_hsa04724	1.83182875
12	Olfactory transduction_Homo sapiens_hsa04740	1.78460700
13	Dopaminergic synapse_Homo sapiens_hsa04728	1.76899138
14	Amphetamine addiction_Homo sapiens_hsa05031	1.74383782
15	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.67933924
16	Butanoate metabolism_Homo sapiens_hsa00650	1.65247590
17	Insulin secretion_Homo sapiens_hsa04911	1.65205740
18	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.62322563
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.58207609
20	Serotonergic synapse_Homo sapiens_hsa04726	1.54364852
21	Long-term potentiation_Homo sapiens_hsa04720	1.53767426
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.51544314
23	Salivary secretion_Homo sapiens_hsa04970	1.46509038
24	Cocaine addiction_Homo sapiens_hsa05030	1.45306864
25	Gap junction_Homo sapiens_hsa04540	1.34576664
26	Cholinergic synapse_Homo sapiens_hsa04725	1.33665481
27	Collecting duct acid secretion_Homo sapiens_hsa04966	1.27347178
28	Phototransduction_Homo sapiens_hsa04744	1.27199319
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.24505381
30	Calcium signaling pathway_Homo sapiens_hsa04020	1.21726315
31	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.21673633
32	cAMP signaling pathway_Homo sapiens_hsa04024	1.20964897
33	Long-term depression_Homo sapiens_hsa04730	1.20265192
34	Gastric acid secretion_Homo sapiens_hsa04971	1.18780905
35	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.17680172
36	Vibrio cholerae infection_Homo sapiens_hsa05110	1.12395716
37	Type II diabetes mellitus_Homo sapiens_hsa04930	1.10895548
38	Axon guidance_Homo sapiens_hsa04360	1.07061535
39	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.00525840
40	Cardiac muscle contraction_Homo sapiens_hsa04260	0.95696874
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.95106961
42	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.92626400
43	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.89251909
44	Circadian rhythm_Homo sapiens_hsa04710	0.87810504
45	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.83569326
46	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.83260489
47	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.80266651
48	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.79849927
49	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.79385509
50	Choline metabolism in cancer_Homo sapiens_hsa05231	0.78965977
51	Estrogen signaling pathway_Homo sapiens_hsa04915	0.76397907
52	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.75297145
53	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.74547916
54	Basal transcription factors_Homo sapiens_hsa03022	0.73544562
55	Regulation of autophagy_Homo sapiens_hsa04140	0.73516652
56	Oocyte meiosis_Homo sapiens_hsa04114	0.72345024
57	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.66137832
58	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.62789807
59	GnRH signaling pathway_Homo sapiens_hsa04912	0.62768608
60	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.62300869
61	Ras signaling pathway_Homo sapiens_hsa04014	0.61862481
62	Renin secretion_Homo sapiens_hsa04924	0.59756229
63	Linoleic acid metabolism_Homo sapiens_hsa00591	0.58627809
64	ABC transporters_Homo sapiens_hsa02010	0.58618104
65	Alcoholism_Homo sapiens_hsa05034	0.58488114
66	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.56170286
67	Ether lipid metabolism_Homo sapiens_hsa00565	0.54719280
68	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.52124182
69	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.52076713
70	Endocytosis_Homo sapiens_hsa04144	0.51735237
71	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.50321731
72	Pancreatic secretion_Homo sapiens_hsa04972	0.49788726
73	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.49142492
74	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.47366619
75	MAPK signaling pathway_Homo sapiens_hsa04010	0.45361748
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.44001998
77	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.43456744
78	Selenocompound metabolism_Homo sapiens_hsa00450	0.42349264
79	Mineral absorption_Homo sapiens_hsa04978	0.41361140
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.40512249
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39559729
82	Melanogenesis_Homo sapiens_hsa04916	0.39348453
83	Bile secretion_Homo sapiens_hsa04976	0.38215673
84	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.37524004
85	Rap1 signaling pathway_Homo sapiens_hsa04015	0.37450760
86	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.37043453
87	Prolactin signaling pathway_Homo sapiens_hsa04917	0.36378918
88	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.34569032
89	Shigellosis_Homo sapiens_hsa05131	0.34565205
90	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.31686642
91	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.31380704
92	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.30985180
93	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.30571692
94	Peroxisome_Homo sapiens_hsa04146	0.30212466
95	Tryptophan metabolism_Homo sapiens_hsa00380	0.30184224
96	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.29272698
97	Type I diabetes mellitus_Homo sapiens_hsa04940	0.28296946
98	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.27564954
99	Caffeine metabolism_Homo sapiens_hsa00232	0.26325075
100	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.24554144

FAM90A11P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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