FAM90A11P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gamma-aminobutyric acid transport (GO:0015812)7.20646290
2phosphorelay signal transduction system (GO:0000160)5.67329605
3response to pheromone (GO:0019236)5.46722257
4negative regulation of synaptic transmission, GABAergic (GO:0032229)4.98039626
5acrosome reaction (GO:0007340)4.89199321
6somite rostral/caudal axis specification (GO:0032525)4.59645750
7synaptic vesicle exocytosis (GO:0016079)4.53365480
8pyrimidine nucleobase catabolic process (GO:0006208)4.45553795
9neurotransmitter-gated ion channel clustering (GO:0072578)4.41399918
10neuronal action potential propagation (GO:0019227)4.38023458
11glycine transport (GO:0015816)4.37383618
12synaptic vesicle maturation (GO:0016188)4.16009126
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.15249185
14protein localization to synapse (GO:0035418)3.91291413
15protein targeting to Golgi (GO:0000042)3.90004877
16sleep (GO:0030431)3.86986271
17establishment of protein localization to Golgi (GO:0072600)3.86861661
18sperm motility (GO:0030317)3.83107518
19neuron cell-cell adhesion (GO:0007158)3.81124963
20neurotransmitter secretion (GO:0007269)3.75249301
21nucleobase catabolic process (GO:0046113)3.72218767
22calcium ion-dependent exocytosis (GO:0017156)3.71570476
23retrograde transport, vesicle recycling within Golgi (GO:0000301)3.61078181
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.60840272
25gamma-aminobutyric acid signaling pathway (GO:0007214)3.60529111
26spermatid nucleus differentiation (GO:0007289)3.55515189
27synaptic transmission, cholinergic (GO:0007271)3.49662239
28retinal cone cell development (GO:0046549)3.47926225
29protein polyglutamylation (GO:0018095)3.47357071
30multicellular organism reproduction (GO:0032504)3.47127390
31membrane depolarization during action potential (GO:0086010)3.46533336
32righting reflex (GO:0060013)3.32203885
33glycosphingolipid biosynthetic process (GO:0006688)3.31330087
34neurotransmitter biosynthetic process (GO:0042136)3.26797631
35negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.26552331
36adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.24088870
37sialylation (GO:0097503)3.22149702
38neuromuscular synaptic transmission (GO:0007274)3.19126701
39establishment of mitochondrion localization (GO:0051654)3.18428886
40sperm capacitation (GO:0048240)3.17310487
41microtubule depolymerization (GO:0007019)3.16712297
42regulation of neurotransmitter levels (GO:0001505)3.15051549
43vocalization behavior (GO:0071625)3.14851757
44ionotropic glutamate receptor signaling pathway (GO:0035235)3.12134109
45proline transport (GO:0015824)3.10913078
46protein localization to Golgi apparatus (GO:0034067)3.06976419
47neuronal ion channel clustering (GO:0045161)3.06959283
48startle response (GO:0001964)3.04513960
49regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.02288017
50negative regulation of cytosolic calcium ion concentration (GO:0051481)3.01091511
51protein insertion into membrane (GO:0051205)3.00130418
52response to histamine (GO:0034776)2.97799487
53cochlea development (GO:0090102)2.96895465
54neurotransmitter metabolic process (GO:0042133)2.96404937
55positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.95705639
56neurotransmitter transport (GO:0006836)2.93635317
57neuronal action potential (GO:0019228)2.92842729
58glutamate secretion (GO:0014047)2.92634615
59neuron-neuron synaptic transmission (GO:0007270)2.89601155
60postsynaptic membrane organization (GO:0001941)2.88004680
61microtubule severing (GO:0051013)2.85603196
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.82253858
63positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.81925576
64reproduction (GO:0000003)2.80876266
65dendrite morphogenesis (GO:0048813)2.79549360
66regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.78855126
67inner ear receptor cell development (GO:0060119)2.76857777
68transmission of nerve impulse (GO:0019226)2.76711734
69glutamate receptor signaling pathway (GO:0007215)2.75766373
70positive regulation of amino acid transport (GO:0051957)2.75574032
71synaptic transmission, glutamatergic (GO:0035249)2.74329718
72neuron recognition (GO:0008038)2.74168309
73piRNA metabolic process (GO:0034587)2.72390050
74microtubule polymerization or depolymerization (GO:0031109)2.72186559
75urinary tract smooth muscle contraction (GO:0014848)2.72143235
76regulation of synaptic transmission, GABAergic (GO:0032228)2.71243357
77male meiosis (GO:0007140)2.70907192
78alanine transport (GO:0032328)2.65142279
79RNA localization (GO:0006403)2.64739889
80regulation of microtubule-based movement (GO:0060632)2.63116731
81negative regulation of interleukin-10 production (GO:0032693)2.62962491
82epithelial cilium movement (GO:0003351)2.62285246
83cerebral cortex neuron differentiation (GO:0021895)2.60478645
84cAMP catabolic process (GO:0006198)2.60280124
85fusion of sperm to egg plasma membrane (GO:0007342)2.59898900
86behavioral response to nicotine (GO:0035095)2.59644362
87regulation of synaptic vesicle exocytosis (GO:2000300)2.57450959
88axonal fasciculation (GO:0007413)2.55935038
89sperm-egg recognition (GO:0035036)2.55438108
90regulation of female receptivity (GO:0045924)2.55358372
91reflex (GO:0060004)2.54903377
92regulation of transcription involved in cell fate commitment (GO:0060850)2.54098815
93single fertilization (GO:0007338)2.53930827
94RNA destabilization (GO:0050779)2.52939615
95dendritic spine organization (GO:0097061)2.52230269
96synaptic vesicle docking involved in exocytosis (GO:0016081)2.51699764
97regulation of cilium movement (GO:0003352)2.51694995
98detection of calcium ion (GO:0005513)2.50419318
99regulation of chemokine-mediated signaling pathway (GO:0070099)2.49867371
100peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.49370686

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.03458181
2GBX2_23144817_ChIP-Seq_PC3_Human3.55459857
3TAF15_26573619_Chip-Seq_HEK293_Human2.43088736
4DROSHA_22980978_ChIP-Seq_HELA_Human2.41363762
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.33648618
6ZNF274_21170338_ChIP-Seq_K562_Hela2.32163689
7REST_21632747_ChIP-Seq_MESCs_Mouse2.31422386
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.30281244
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28678320
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.19431853
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08715650
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.06892332
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06867188
14EZH2_27294783_Chip-Seq_ESCs_Mouse1.91842449
15EZH2_27304074_Chip-Seq_ESCs_Mouse1.90312563
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88259135
17SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86647202
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85199146
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.80015923
20REST_18959480_ChIP-ChIP_MESCs_Mouse1.79806149
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.79299601
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78169334
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75412879
24SMAD4_21799915_ChIP-Seq_A2780_Human1.69082948
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.67877825
26SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.63725546
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63464771
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63307345
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63003713
30AR_25329375_ChIP-Seq_VCAP_Human1.62726499
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.55260496
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53832665
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52733342
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52733342
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52631061
36STAT3_23295773_ChIP-Seq_U87_Human1.52120489
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52102123
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51769083
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51269372
40CBP_20019798_ChIP-Seq_JUKART_Human1.50594724
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50594724
42ER_23166858_ChIP-Seq_MCF-7_Human1.44572591
43AR_21572438_ChIP-Seq_LNCaP_Human1.43197153
44SOX2_21211035_ChIP-Seq_LN229_Gbm1.42683467
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42615384
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42177999
47IRF1_19129219_ChIP-ChIP_H3396_Human1.41330312
48P300_19829295_ChIP-Seq_ESCs_Human1.41118938
49SMAD4_21741376_ChIP-Seq_EPCs_Human1.40006303
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38153658
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.37896686
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.35468932
53FUS_26573619_Chip-Seq_HEK293_Human1.34006949
54IGF1R_20145208_ChIP-Seq_DFB_Human1.29020138
55TCF4_23295773_ChIP-Seq_U87_Human1.26525714
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24876930
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24876930
58PRDM14_20953172_ChIP-Seq_ESCs_Human1.24090753
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.19271352
60RUNX2_22187159_ChIP-Seq_PCA_Human1.16403852
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14571322
62AR_19668381_ChIP-Seq_PC3_Human1.14307965
63EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.13071585
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.09898026
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09631471
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09369520
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08932079
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07596847
69RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05931154
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05883095
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03103218
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02138973
73SOX2_19829295_ChIP-Seq_ESCs_Human1.01975695
74NANOG_19829295_ChIP-Seq_ESCs_Human1.01975695
75RNF2_27304074_Chip-Seq_NSC_Mouse1.01889686
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.01259202
77MYC_19829295_ChIP-Seq_ESCs_Human1.00740718
78KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97825052
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97490096
80ERA_21632823_ChIP-Seq_H3396_Human0.96763761
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96179104
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96095838
83SMAD4_21741376_ChIP-Seq_HESCs_Human0.95690711
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95555746
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94370796
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94137614
87NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93335693
88KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.93317511
89AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93247078
90PIAS1_25552417_ChIP-Seq_VCAP_Human0.92801199
91IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92713562
92DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92688990
93TCF4_18268006_ChIP-ChIP_LS174T_Human0.89757048
94TAL1_26923725_Chip-Seq_HPCs_Mouse0.89665418
95SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89594620
96TBL1_22424771_ChIP-Seq_293T_Human0.89113615
97AHR_22903824_ChIP-Seq_MCF-7_Human0.88327172
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87998956
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87561334
100TP53_18474530_ChIP-ChIP_U2OS_Human0.86986950

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.75578084
2MP0004270_analgesia3.60605820
3MP0005410_abnormal_fertilization3.01796705
4MP0003635_abnormal_synaptic_transmissio2.93394640
5MP0001486_abnormal_startle_reflex2.70810006
6MP0009745_abnormal_behavioral_response2.64735266
7MP0002272_abnormal_nervous_system2.60564269
8MP0005423_abnormal_somatic_nervous2.57158827
9MP0001986_abnormal_taste_sensitivity2.50661002
10MP0001968_abnormal_touch/_nociception2.47022125
11MP0001529_abnormal_vocalization2.46144914
12MP0003879_abnormal_hair_cell2.44407401
13MP0002064_seizures2.40797710
14MP0005377_hearing/vestibular/ear_phenot2.40360429
15MP0003878_abnormal_ear_physiology2.40360429
16MP0001501_abnormal_sleep_pattern2.37861155
17MP0002063_abnormal_learning/memory/cond2.17148101
18MP0003880_abnormal_central_pattern2.13161230
19MP0002572_abnormal_emotion/affect_behav2.08092088
20MP0009046_muscle_twitch2.06552972
21MP0002735_abnormal_chemical_nociception2.04309458
22MP0008961_abnormal_basal_metabolism1.94321420
23MP0002734_abnormal_mechanical_nocicepti1.91220085
24MP0004142_abnormal_muscle_tone1.86662829
25MP0008877_abnormal_DNA_methylation1.86266510
26MP0002067_abnormal_sensory_capabilities1.82697302
27MP0004147_increased_porphyrin_level1.81730353
28MP0005670_abnormal_white_adipose1.80263356
29MP0002557_abnormal_social/conspecific_i1.76732847
30MP0002736_abnormal_nociception_after1.72805663
31MP0002653_abnormal_ependyma_morphology1.65762782
32MP0004043_abnormal_pH_regulation1.64115318
33MP0005394_taste/olfaction_phenotype1.59290934
34MP0005499_abnormal_olfactory_system1.59290934
35MP0006276_abnormal_autonomic_nervous1.57698070
36MP0002733_abnormal_thermal_nociception1.57491670
37MP0009780_abnormal_chondrocyte_physiolo1.54431926
38MP0001984_abnormal_olfaction1.52959887
39MP0001970_abnormal_pain_threshold1.52682239
40MP0008789_abnormal_olfactory_epithelium1.49156088
41MP0004811_abnormal_neuron_physiology1.44900525
42MP0005084_abnormal_gallbladder_morpholo1.43171556
43MP0000955_abnormal_spinal_cord1.42661534
44MP0003698_abnormal_male_reproductive1.40754109
45MP0001440_abnormal_grooming_behavior1.39754111
46MP0005623_abnormal_meninges_morphology1.36714024
47MP0008569_lethality_at_weaning1.31901068
48MP0002184_abnormal_innervation1.29568863
49MP0002882_abnormal_neuron_morphology1.23879039
50MP0004924_abnormal_behavior1.23807515
51MP0005386_behavior/neurological_phenoty1.23807515
52MP0000778_abnormal_nervous_system1.21343161
53MP0005551_abnormal_eye_electrophysiolog1.20655805
54MP0001177_atelectasis1.19832543
55MP0003329_amyloid_beta_deposits1.18762645
56MP0002909_abnormal_adrenal_gland1.17150264
57MP0000372_irregular_coat_pigmentation1.15795873
58MP0008872_abnormal_physiological_respon1.14465875
59MP0002876_abnormal_thyroid_physiology1.14421180
60MP0003646_muscle_fatigue1.12650994
61MP0001188_hyperpigmentation1.11121383
62MP0004134_abnormal_chest_morphology1.09847284
63MP0002249_abnormal_larynx_morphology1.09059229
64MP0002066_abnormal_motor_capabilities/c1.09018023
65MP0001502_abnormal_circadian_rhythm1.08630986
66MP0005645_abnormal_hypothalamus_physiol1.08209761
67MP0003718_maternal_effect1.06749896
68MP0006292_abnormal_olfactory_placode1.05104072
69MP0000026_abnormal_inner_ear1.04632819
70MP0004885_abnormal_endolymph1.04082250
71MP0001929_abnormal_gametogenesis1.03293065
72MP0001963_abnormal_hearing_physiology1.03051295
73MP0002277_abnormal_respiratory_mucosa1.01814382
74MP0002822_catalepsy0.98624059
75MP0003633_abnormal_nervous_system0.98623646
76MP0004742_abnormal_vestibular_system0.98509404
77MP0003938_abnormal_ear_development0.97812387
78MP0002229_neurodegeneration0.93582380
79MP0004233_abnormal_muscle_weight0.90523051
80MP0002752_abnormal_somatic_nervous0.89838887
81MP0002132_abnormal_respiratory_system0.87049271
82MP0001485_abnormal_pinna_reflex0.86182696
83MP0001879_abnormal_lymphatic_vessel0.86013991
84MP0010386_abnormal_urinary_bladder0.85797671
85MP0001905_abnormal_dopamine_level0.85465134
86MP0002069_abnormal_eating/drinking_beha0.84034560
87MP0000049_abnormal_middle_ear0.83999482
88MP0003631_nervous_system_phenotype0.82980559
89MP0000733_abnormal_muscle_development0.81364817
90MP0004133_heterotaxia0.80894528
91MP0000631_abnormal_neuroendocrine_gland0.80467770
92MP0002161_abnormal_fertility/fecundity0.79189054
93MP0004085_abnormal_heartbeat0.78789513
94MP0001270_distended_abdomen0.78479082
95MP0003137_abnormal_impulse_conducting0.76917846
96MP0003122_maternal_imprinting0.73988866
97MP0002152_abnormal_brain_morphology0.72074865
98MP0000013_abnormal_adipose_tissue0.71968635
99MP0003183_abnormal_peptide_metabolism0.71312244
100MP0001348_abnormal_lacrimal_gland0.69755173

Predicted human phenotypes

RankGene SetZ-score
1Atonic seizures (HP:0010819)4.95455759
2Focal motor seizures (HP:0011153)4.91315568
3Progressive cerebellar ataxia (HP:0002073)4.42471835
4Ankle clonus (HP:0011448)4.13151529
5Myokymia (HP:0002411)3.90229919
6Action tremor (HP:0002345)3.90219921
7Spastic gait (HP:0002064)3.82212636
8Febrile seizures (HP:0002373)3.70805968
9Urinary urgency (HP:0000012)3.66102524
10Drooling (HP:0002307)3.63711278
11Genetic anticipation (HP:0003743)3.62331407
12Excessive salivation (HP:0003781)3.39204306
13Hemiparesis (HP:0001269)3.36513806
14Focal seizures (HP:0007359)3.30511123
15Supranuclear gaze palsy (HP:0000605)3.10594856
16Dialeptic seizures (HP:0011146)3.05174082
17Failure to thrive in infancy (HP:0001531)2.97176632
18Absence seizures (HP:0002121)2.95658286
19Dysdiadochokinesis (HP:0002075)2.88806698
20Split foot (HP:0001839)2.88116642
21Dynein arm defect of respiratory motile cilia (HP:0012255)2.84333730
22Absent/shortened dynein arms (HP:0200106)2.84333730
23Epileptic encephalopathy (HP:0200134)2.82753664
24Epileptiform EEG discharges (HP:0011182)2.80614624
25Generalized tonic-clonic seizures (HP:0002069)2.77564841
26Hypsarrhythmia (HP:0002521)2.72410828
27EEG with generalized epileptiform discharges (HP:0011198)2.71143866
28Lower limb muscle weakness (HP:0007340)2.65439200
29Dysmetria (HP:0001310)2.56846816
30Pendular nystagmus (HP:0012043)2.51946542
31Poor eye contact (HP:0000817)2.48027584
32Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.45661823
33Absent speech (HP:0001344)2.43658615
34Lissencephaly (HP:0001339)2.43538438
35Abnormal ciliary motility (HP:0012262)2.41499131
36Hyperglycinemia (HP:0002154)2.39895386
37Prominent supraorbital ridges (HP:0000336)2.37554836
38Neurofibrillary tangles (HP:0002185)2.36163576
39Urinary bladder sphincter dysfunction (HP:0002839)2.32458239
40Clonus (HP:0002169)2.31004742
41Papillary thyroid carcinoma (HP:0002895)2.26754343
42Aplasia/Hypoplasia of the brainstem (HP:0007362)2.23719850
43Hypoplasia of the brainstem (HP:0002365)2.23719850
44Polyphagia (HP:0002591)2.23286163
45Abnormal respiratory motile cilium morphology (HP:0005938)2.21147362
46Abnormal respiratory epithelium morphology (HP:0012253)2.21147362
47Chronic hepatic failure (HP:0100626)2.20849951
48Esotropia (HP:0000565)2.18786554
49Truncal obesity (HP:0001956)2.16135655
50Severe visual impairment (HP:0001141)2.15303917
51Delusions (HP:0000746)2.14117596
52Abnormality of the pubic bones (HP:0003172)2.13214237
53Neoplasm of the heart (HP:0100544)2.11268097
54Tubulointerstitial nephritis (HP:0001970)2.08854226
55Abnormality of dental color (HP:0011073)2.08765901
56Gaze-evoked nystagmus (HP:0000640)2.05041295
57Optic nerve hypoplasia (HP:0000609)2.04788089
58Postural instability (HP:0002172)2.04328862
59Unilateral renal agenesis (HP:0000122)2.03945874
60Abnormal respiratory motile cilium physiology (HP:0012261)2.03274397
61Global brain atrophy (HP:0002283)2.00195369
62Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.98930756
63Hyperventilation (HP:0002883)1.98855521
64Type II lissencephaly (HP:0007260)1.97621415
65Spastic paraplegia (HP:0001258)1.96854535
66Opisthotonus (HP:0002179)1.96779669
67Bony spicule pigmentary retinopathy (HP:0007737)1.95472428
68Abnormality of binocular vision (HP:0011514)1.90231558
69Diplopia (HP:0000651)1.90231558
70Status epilepticus (HP:0002133)1.89741573
71Renal Fanconi syndrome (HP:0001994)1.89563955
72Amyotrophic lateral sclerosis (HP:0007354)1.88700573
73Congenital stationary night blindness (HP:0007642)1.88615170
74Gait imbalance (HP:0002141)1.88310870
75Paraplegia (HP:0010550)1.88223848
76Thyroid-stimulating hormone excess (HP:0002925)1.87919471
77Visual hallucinations (HP:0002367)1.87349916
78Mutism (HP:0002300)1.85547123
79Cerebral inclusion bodies (HP:0100314)1.81254178
80Methylmalonic acidemia (HP:0002912)1.81244254
81Nephronophthisis (HP:0000090)1.81038205
82Abnormal eating behavior (HP:0100738)1.80983493
83Cerebellar dysplasia (HP:0007033)1.80672228
84Enlarged epiphyses (HP:0010580)1.80417682
85Limb dystonia (HP:0002451)1.79134613
86Inability to walk (HP:0002540)1.78549298
87Exertional dyspnea (HP:0002875)1.77977926
88Protruding tongue (HP:0010808)1.76028522
89Glycosuria (HP:0003076)1.75885542
90Abnormality of urine glucose concentration (HP:0011016)1.75885542
91Impaired smooth pursuit (HP:0007772)1.74854580
92Abnormality of salivation (HP:0100755)1.74765196
93Impaired social interactions (HP:0000735)1.74427826
94Abnormal social behavior (HP:0012433)1.74427826
95Spastic tetraplegia (HP:0002510)1.72231533
96Infertility (HP:0000789)1.71502552
97Retinal dysplasia (HP:0007973)1.71486053
98Intention tremor (HP:0002080)1.71321527
99Rhinitis (HP:0012384)1.70645760
100Lower limb hyperreflexia (HP:0002395)1.70197880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.29491252
2MAP3K63.86497501
3MAP3K93.28186123
4MAP3K43.06008320
5ARAF3.05319221
6TESK12.50413418
7BRD42.48020826
8MAP4K22.39350540
9MAP2K72.31108839
10NTRK22.23483484
11INSRR2.20680339
12PINK12.16488968
13NTRK31.91520445
14KSR21.80071862
15CASK1.72468967
16RAF11.62447196
17MAPK131.62082775
18BCKDK1.60224354
19TAOK11.52845448
20MAP3K131.46586456
21ERBB31.41803075
22MARK21.39893498
23PLK21.37420692
24STK381.36344383
25MAP2K41.33541577
26STK38L1.32811737
27GRK61.30934203
28TLK11.29594896
29PRKCG1.18985842
30DAPK21.13163107
31ICK1.11800555
32ADRBK21.05996447
33SIK21.00225501
34WNK30.97693434
35WNK10.97418206
36TAOK30.96632664
37PHKG10.94551645
38PHKG20.94551645
39BRAF0.94226611
40PKN10.92153889
41NEK60.91183385
42EPHA40.88387725
43PRKCE0.88007137
44PAK60.87819238
45PAK30.87177623
46MAP3K140.86787064
47UHMK10.82674664
48EPHA30.82620743
49RPS6KA20.77830166
50CSNK1G20.77123263
51MAP2K60.76961339
52MAPK150.76029682
53FGFR20.75996038
54CDK50.75470736
55MINK10.75172865
56RET0.74530744
57TESK20.74132487
58CAMK2A0.73846837
59TNIK0.72870373
60DYRK20.72274793
61DDR20.70001562
62RPS6KA40.69395308
63AKT30.68693197
64PIK3CG0.68544949
65PRKCZ0.65793371
66LIMK10.64581488
67CSNK1G30.64090170
68MUSK0.62466550
69GRK10.59944671
70CSNK1A1L0.59198334
71ZAK0.58366804
72CDK30.57300805
73CAMK10.56867739
74KSR10.55258836
75TRIM280.54463960
76DAPK10.53546940
77PRKAA10.50727506
78CAMK40.50312310
79PDK10.50182781
80RPS6KA30.49754037
81PRKACA0.49247358
82PRKACB0.46131487
83PRKG10.45388379
84CAMK2B0.44082062
85PRKCB0.43823650
86GRK50.41902993
87PLK40.40959887
88MAP3K70.39543637
89PRKCA0.38813955
90CSNK1G10.38800464
91PDPK10.36899876
92PRKCQ0.34987200
93CAMKK10.34605215
94FRK0.32937131
95SGK2230.31900406
96SGK4940.31900406
97PRKCI0.30702821
98PRKD20.30677537
99CSNK1D0.30664147
100GSK3B0.30320431

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.95342273
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.59955131
3GABAergic synapse_Homo sapiens_hsa047273.59421320
4Morphine addiction_Homo sapiens_hsa050323.11114008
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.94495473
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.55504478
7Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.52140134
8Synaptic vesicle cycle_Homo sapiens_hsa047212.34945051
9Circadian entrainment_Homo sapiens_hsa047132.25564563
10Taste transduction_Homo sapiens_hsa047422.14618186
11Glutamatergic synapse_Homo sapiens_hsa047241.83182875
12Olfactory transduction_Homo sapiens_hsa047401.78460700
13Dopaminergic synapse_Homo sapiens_hsa047281.76899138
14Amphetamine addiction_Homo sapiens_hsa050311.74383782
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.67933924
16Butanoate metabolism_Homo sapiens_hsa006501.65247590
17Insulin secretion_Homo sapiens_hsa049111.65205740
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62322563
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58207609
20Serotonergic synapse_Homo sapiens_hsa047261.54364852
21Long-term potentiation_Homo sapiens_hsa047201.53767426
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51544314
23Salivary secretion_Homo sapiens_hsa049701.46509038
24Cocaine addiction_Homo sapiens_hsa050301.45306864
25Gap junction_Homo sapiens_hsa045401.34576664
26Cholinergic synapse_Homo sapiens_hsa047251.33665481
27Collecting duct acid secretion_Homo sapiens_hsa049661.27347178
28Phototransduction_Homo sapiens_hsa047441.27199319
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24505381
30Calcium signaling pathway_Homo sapiens_hsa040201.21726315
31Phospholipase D signaling pathway_Homo sapiens_hsa040721.21673633
32cAMP signaling pathway_Homo sapiens_hsa040241.20964897
33Long-term depression_Homo sapiens_hsa047301.20265192
34Gastric acid secretion_Homo sapiens_hsa049711.18780905
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17680172
36Vibrio cholerae infection_Homo sapiens_hsa051101.12395716
37Type II diabetes mellitus_Homo sapiens_hsa049301.10895548
38Axon guidance_Homo sapiens_hsa043601.07061535
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00525840
40Cardiac muscle contraction_Homo sapiens_hsa042600.95696874
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95106961
42Oxytocin signaling pathway_Homo sapiens_hsa049210.92626400
43Ovarian steroidogenesis_Homo sapiens_hsa049130.89251909
44Circadian rhythm_Homo sapiens_hsa047100.87810504
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.83569326
46Dorso-ventral axis formation_Homo sapiens_hsa043200.83260489
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80266651
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79849927
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79385509
50Choline metabolism in cancer_Homo sapiens_hsa052310.78965977
51Estrogen signaling pathway_Homo sapiens_hsa049150.76397907
52Glycerophospholipid metabolism_Homo sapiens_hsa005640.75297145
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74547916
54Basal transcription factors_Homo sapiens_hsa030220.73544562
55Regulation of autophagy_Homo sapiens_hsa041400.73516652
56Oocyte meiosis_Homo sapiens_hsa041140.72345024
57Thyroid hormone synthesis_Homo sapiens_hsa049180.66137832
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62789807
59GnRH signaling pathway_Homo sapiens_hsa049120.62768608
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62300869
61Ras signaling pathway_Homo sapiens_hsa040140.61862481
62Renin secretion_Homo sapiens_hsa049240.59756229
63Linoleic acid metabolism_Homo sapiens_hsa005910.58627809
64ABC transporters_Homo sapiens_hsa020100.58618104
65Alcoholism_Homo sapiens_hsa050340.58488114
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56170286
67Ether lipid metabolism_Homo sapiens_hsa005650.54719280
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52124182
69Inositol phosphate metabolism_Homo sapiens_hsa005620.52076713
70Endocytosis_Homo sapiens_hsa041440.51735237
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50321731
72Pancreatic secretion_Homo sapiens_hsa049720.49788726
73Dilated cardiomyopathy_Homo sapiens_hsa054140.49142492
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47366619
75MAPK signaling pathway_Homo sapiens_hsa040100.45361748
76beta-Alanine metabolism_Homo sapiens_hsa004100.44001998
77Fatty acid biosynthesis_Homo sapiens_hsa000610.43456744
78Selenocompound metabolism_Homo sapiens_hsa004500.42349264
79Mineral absorption_Homo sapiens_hsa049780.41361140
80Glycerolipid metabolism_Homo sapiens_hsa005610.40512249
81Arginine and proline metabolism_Homo sapiens_hsa003300.39559729
82Melanogenesis_Homo sapiens_hsa049160.39348453
83Bile secretion_Homo sapiens_hsa049760.38215673
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37524004
85Rap1 signaling pathway_Homo sapiens_hsa040150.37450760
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37043453
87Prolactin signaling pathway_Homo sapiens_hsa049170.36378918
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34569032
89Shigellosis_Homo sapiens_hsa051310.34565205
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31686642
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31380704
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30985180
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.30571692
94Peroxisome_Homo sapiens_hsa041460.30212466
95Tryptophan metabolism_Homo sapiens_hsa003800.30184224
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29272698
97Type I diabetes mellitus_Homo sapiens_hsa049400.28296946
98Arachidonic acid metabolism_Homo sapiens_hsa005900.27564954
99Caffeine metabolism_Homo sapiens_hsa002320.26325075
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24554144

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