ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	8.74278138
2	regulation of retinoic acid receptor signaling pathway (GO:0048385)	7.28435895
3	piRNA metabolic process (GO:0034587)	6.80745953
4	histone H3-K9 demethylation (GO:0033169)	6.56673464
5	glycine transport (GO:0015816)	6.26998273
6	phosphorelay signal transduction system (GO:0000160)	6.11615257
7	positive regulation of uterine smooth muscle contraction (GO:0070474)	6.11576873
8	multicellular organism reproduction (GO:0032504)	5.93157342
9	somite rostral/caudal axis specification (GO:0032525)	5.82813850
10	retinal cone cell development (GO:0046549)	5.72131526
11	regulation of acrosome reaction (GO:0060046)	5.62979015
12	positive regulation of gastrulation (GO:2000543)	5.59448061
13	meiotic cell cycle (GO:0051321)	5.34020046
14	regulation of female gonad development (GO:2000194)	5.30739670
15	male meiosis (GO:0007140)	5.03363379
16	positive regulation of histone H3-K4 methylation (GO:0051571)	5.01140231
17	oocyte development (GO:0048599)	4.91413445
18	regulation of DNA methylation (GO:0044030)	4.75246227
19	male meiosis I (GO:0007141)	4.74004808
20	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	4.65666402
21	positive regulation of meiosis (GO:0045836)	4.55192889
22	regulation of uterine smooth muscle contraction (GO:0070472)	4.53021188
23	DNA methylation involved in gamete generation (GO:0043046)	4.43485546
24	synaptonemal complex assembly (GO:0007130)	4.37689397
25	positive regulation of meiotic cell cycle (GO:0051446)	4.30633960
26	regulation of histone H3-K9 methylation (GO:0051570)	4.27082682
27	regulation of female receptivity (GO:0045924)	4.26072548
28	gonadal mesoderm development (GO:0007506)	4.22266984
29	regulation of meiosis I (GO:0060631)	4.20565199
30	gamma-aminobutyric acid transport (GO:0015812)	4.05010185
31	synaptonemal complex organization (GO:0070193)	3.98257372
32	synapsis (GO:0007129)	3.96922793
33	reproduction (GO:0000003)	3.95660072
34	regulation of sensory perception (GO:0051931)	3.91073910
35	regulation of sensory perception of pain (GO:0051930)	3.91073910
36	detection of light stimulus involved in sensory perception (GO:0050962)	3.84317267
37	detection of light stimulus involved in visual perception (GO:0050908)	3.84317267
38	negative regulation of digestive system process (GO:0060457)	3.81084505
39	sleep (GO:0030431)	3.79351430
40	single fertilization (GO:0007338)	3.78682141
41	meiosis I (GO:0007127)	3.74683729
42	cellular response to pH (GO:0071467)	3.74057532
43	chromosome organization involved in meiosis (GO:0070192)	3.73829766
44	primitive streak formation (GO:0090009)	3.66007967
45	N-terminal protein amino acid acetylation (GO:0006474)	3.61863674
46	intestinal cholesterol absorption (GO:0030299)	3.59521431
47	L-amino acid import (GO:0043092)	3.57384489
48	aggressive behavior (GO:0002118)	3.55546093
49	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.51481248
50	regulation of cell maturation (GO:1903429)	3.42536695
51	female mating behavior (GO:0060180)	3.41198425
52	epithelial cilium movement (GO:0003351)	3.40357039
53	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.38005151
54	positive regulation of prostaglandin secretion (GO:0032308)	3.34165455
55	positive regulation of catecholamine secretion (GO:0033605)	3.33085345
56	hyperosmotic salinity response (GO:0042538)	3.31176934
57	meiotic nuclear division (GO:0007126)	3.30753042
58	fertilization (GO:0009566)	3.30083660
59	negative regulation of histone methylation (GO:0031061)	3.27711870
60	positive regulation of endothelial cell differentiation (GO:0045603)	3.26662684
61	regulation of G0 to G1 transition (GO:0070316)	3.25280377
62	DNA replication-dependent nucleosome assembly (GO:0006335)	3.20970650
63	DNA replication-dependent nucleosome organization (GO:0034723)	3.20970650
64	gene silencing by RNA (GO:0031047)	3.16907324
65	cellular response to electrical stimulus (GO:0071257)	3.15611816
66	regulation of meiosis (GO:0040020)	3.12395446
67	cerebellar Purkinje cell differentiation (GO:0021702)	3.11325668
68	cilium or flagellum-dependent cell motility (GO:0001539)	3.10518582
69	cilium movement (GO:0003341)	3.10493760
70	type B pancreatic cell development (GO:0003323)	3.10082618
71	cochlea development (GO:0090102)	3.09393217
72	protein kinase C signaling (GO:0070528)	3.06792329
73	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.05769781
74	photoreceptor cell maintenance (GO:0045494)	3.04105205
75	regulation of steroid hormone secretion (GO:2000831)	3.03662626
76	sperm-egg recognition (GO:0035036)	2.98980925
77	negative regulation of reproductive process (GO:2000242)	2.95688777
78	cellular biogenic amine biosynthetic process (GO:0042401)	2.91637666
79	regulation of meiotic cell cycle (GO:0051445)	2.90772645
80	binding of sperm to zona pellucida (GO:0007339)	2.90668671
81	positive regulation of digestive system process (GO:0060456)	2.90573656
82	DNA methylation (GO:0006306)	2.90375550
83	DNA alkylation (GO:0006305)	2.90375550
84	drinking behavior (GO:0042756)	2.88687434
85	amino acid import (GO:0043090)	2.86116094
86	regulation of prostaglandin secretion (GO:0032306)	2.77593910
87	meiotic cell cycle process (GO:1903046)	2.76541108
88	amine biosynthetic process (GO:0009309)	2.75420980
89	positive regulation of reproductive process (GO:2000243)	2.73275059
90	L-fucose catabolic process (GO:0042355)	2.66949362
91	fucose catabolic process (GO:0019317)	2.66949362
92	L-fucose metabolic process (GO:0042354)	2.66949362
93	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.66056974
94	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.66056974
95	neuronal action potential (GO:0019228)	2.63776174
96	neuronal action potential propagation (GO:0019227)	2.62680633
97	endoderm formation (GO:0001706)	2.62035767
98	regulation of penile erection (GO:0060405)	2.62032326
99	regulation of endothelial cell differentiation (GO:0045601)	2.61529959
100	cAMP catabolic process (GO:0006198)	2.59642634

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	9.58308640
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.39439569
3	GBX2_23144817_ChIP-Seq_PC3_Human	4.10790665
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.66472202
5	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.39035681
6	VDR_22108803_ChIP-Seq_LS180_Human	2.32663435
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.32019550
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.19336987
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.04616064
10	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.04424199
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.94168491
12	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.92303571
13	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.88666858
14	IRF1_19129219_ChIP-ChIP_H3396_Human	1.83876346
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81155178
16	SMAD4_21799915_ChIP-Seq_A2780_Human	1.75101872
17	STAT3_23295773_ChIP-Seq_U87_Human	1.74112938
18	IGF1R_20145208_ChIP-Seq_DFB_Human	1.73165589
19	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.65622169
20	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.64398670
21	DROSHA_22980978_ChIP-Seq_HELA_Human	1.63861406
22	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.60097363
23	AR_25329375_ChIP-Seq_VCAP_Human	1.59432240
24	TCF4_23295773_ChIP-Seq_U87_Human	1.57635498
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.54931838
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.54414412
27	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.52936121
28	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.52688336
29	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.52627672
30	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.52311704
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50454048
32	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.49579369
33	P300_19829295_ChIP-Seq_ESCs_Human	1.48575023
34	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.47039828
35	REST_21632747_ChIP-Seq_MESCs_Mouse	1.46678970
36	RUNX2_22187159_ChIP-Seq_PCA_Human	1.45570442
37	BCAT_22108803_ChIP-Seq_LS180_Human	1.45567042
38	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.44790555
39	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.44740906
40	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.44740906
41	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.44740906
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43709186
43	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.43558120
44	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.39460443
45	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.34805753
46	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.33272270
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.31680670
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.31680670
49	AR_21572438_ChIP-Seq_LNCaP_Human	1.29274385
50	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.29024216
51	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.27800578
52	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25951033
53	RNF2_27304074_Chip-Seq_NSC_Mouse	1.24730023
54	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.22474343
55	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.21992521
56	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.18153954
57	NANOG_20526341_ChIP-Seq_ESCs_Human	1.17383165
58	TCF4_22108803_ChIP-Seq_LS180_Human	1.16814913
59	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.16425853
60	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.15902087
61	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.15446643
62	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.14886996
63	NCOR_22424771_ChIP-Seq_293T_Human	1.14356465
64	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.14214175
65	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.14137506
66	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.12885457
67	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.12582289
68	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12582289
69	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.11826513
70	TP53_22573176_ChIP-Seq_HFKS_Human	1.11553959
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10187017
72	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.10031828
73	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.08741484
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.08393204
75	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.07973399
76	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06725003
77	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06205238
78	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06205238
79	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.03329357
80	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.02396789
81	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02066087
82	OCT4_20526341_ChIP-Seq_ESCs_Human	1.01607939
83	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01261907
84	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.00792823
85	EWS_26573619_Chip-Seq_HEK293_Human	0.99755249
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99677318
87	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.97320436
88	RAC3_21632823_ChIP-Seq_H3396_Human	0.97135790
89	RXR_22108803_ChIP-Seq_LS180_Human	0.96989129
90	TBL1_22424771_ChIP-Seq_293T_Human	0.96958554
91	TAF2_19829295_ChIP-Seq_ESCs_Human	0.96795131
92	MYC_18940864_ChIP-ChIP_HL60_Human	0.95512081
93	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.95464107
94	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.95464107
95	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.95155817
96	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94022896
97	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.93573736
98	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.93188406
99	AR_20517297_ChIP-Seq_VCAP_Human	0.92469781
100	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.91477788

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.52040921
2	MP0003718_maternal_effect	3.37410072
3	MP0003890_abnormal_embryonic-extraembry	2.95589404
4	MP0001666_abnormal_nutrient_absorption	2.87617942
5	MP0008877_abnormal_DNA_methylation	2.86559095
6	MP0003879_abnormal_hair_cell	2.85625397
7	MP0002736_abnormal_nociception_after	2.58349824
8	MP0008789_abnormal_olfactory_epithelium	2.44010077
9	MP0005394_taste/olfaction_phenotype	2.36798758
10	MP0005499_abnormal_olfactory_system	2.36798758
11	MP0005410_abnormal_fertilization	2.36660426
12	MP0001968_abnormal_touch/_nociception	2.35865570
13	MP0003283_abnormal_digestive_organ	2.24130581
14	MP0003252_abnormal_bile_duct	2.23798016
15	MP0003136_yellow_coat_color	2.15512662
16	MP0001929_abnormal_gametogenesis	2.12150351
17	MP0002138_abnormal_hepatobiliary_system	2.08108526
18	MP0002272_abnormal_nervous_system	2.07553725
19	MP0001664_abnormal_digestion	1.90614413
20	MP0002160_abnormal_reproductive_system	1.90373194
21	MP0002210_abnormal_sex_determination	1.85197872
22	MP0000427_abnormal_hair_cycle	1.83781161
23	MP0003195_calcinosis	1.82369192
24	MP0006276_abnormal_autonomic_nervous	1.81984741
25	MP0004043_abnormal_pH_regulation	1.74798991
26	MP0001529_abnormal_vocalization	1.74144800
27	MP0002837_dystrophic_cardiac_calcinosis	1.73967829
28	MP0005551_abnormal_eye_electrophysiolog	1.73607300
29	MP0003693_abnormal_embryo_hatching	1.71425916
30	MP0003121_genomic_imprinting	1.64687496
31	MP0003698_abnormal_male_reproductive	1.63070372
32	MP0003699_abnormal_female_reproductive	1.59004245
33	MP0001486_abnormal_startle_reflex	1.54734947
34	MP0001501_abnormal_sleep_pattern	1.52798424
35	MP0001502_abnormal_circadian_rhythm	1.51379340
36	MP0004142_abnormal_muscle_tone	1.50754572
37	MP0005360_urolithiasis	1.50632263
38	MP0002067_abnormal_sensory_capabilities	1.49674620
39	MP0003950_abnormal_plasma_membrane	1.45656542
40	MP0005646_abnormal_pituitary_gland	1.43478296
41	MP0000049_abnormal_middle_ear	1.42298900
42	MP0000653_abnormal_sex_gland	1.39247462
43	MP0003646_muscle_fatigue	1.38852537
44	MP0008995_early_reproductive_senescence	1.38543953
45	MP0003635_abnormal_synaptic_transmissio	1.37955697
46	MP0002735_abnormal_chemical_nociception	1.37699453
47	MP0009745_abnormal_behavioral_response	1.37406515
48	MP0004924_abnormal_behavior	1.37112361
49	MP0005386_behavior/neurological_phenoty	1.37112361
50	MP0009046_muscle_twitch	1.36943899
51	MP0003878_abnormal_ear_physiology	1.36622531
52	MP0005377_hearing/vestibular/ear_phenot	1.36622531
53	MP0001986_abnormal_taste_sensitivity	1.33875853
54	MP0002161_abnormal_fertility/fecundity	1.31457324
55	MP0003868_abnormal_feces_composition	1.31380912
56	MP0001485_abnormal_pinna_reflex	1.30484892
57	MP0002557_abnormal_social/conspecific_i	1.30365862
58	MP0000678_abnormal_parathyroid_gland	1.29909497
59	MP0003959_abnormal_lean_body	1.27912608
60	MP0008058_abnormal_DNA_repair	1.24677700
61	MP0005645_abnormal_hypothalamus_physiol	1.24007392
62	MP0001145_abnormal_male_reproductive	1.23343545
63	MP0009379_abnormal_foot_pigmentation	1.22011876
64	MP0002572_abnormal_emotion/affect_behav	1.21892025
65	MP0001963_abnormal_hearing_physiology	1.19116733
66	MP0000566_synostosis	1.17231701
67	MP0005395_other_phenotype	1.16572525
68	MP0000631_abnormal_neuroendocrine_gland	1.15257118
69	MP0001984_abnormal_olfaction	1.14819334
70	MP0004084_abnormal_cardiac_muscle	1.13054561
71	MP0002734_abnormal_mechanical_nocicepti	1.13007660
72	MP0003119_abnormal_digestive_system	1.12494522
73	MP0004233_abnormal_muscle_weight	1.07451813
74	MP0005670_abnormal_white_adipose	1.04113880
75	MP0004742_abnormal_vestibular_system	1.03886111
76	MP0005647_abnormal_sex_gland	1.03125701
77	MP0002102_abnormal_ear_morphology	1.00880311
78	MP0010368_abnormal_lymphatic_system	0.98799518
79	MP0002234_abnormal_pharynx_morphology	0.98081050
80	MP0000372_irregular_coat_pigmentation	0.96373760
81	MP0010030_abnormal_orbit_morphology	0.96222040
82	MP0002876_abnormal_thyroid_physiology	0.96084577
83	MP0002229_neurodegeneration	0.95783896
84	MP0000026_abnormal_inner_ear	0.95371644
85	MP0001119_abnormal_female_reproductive	0.93147191
86	MP0002063_abnormal_learning/memory/cond	0.92367477
87	MP0003183_abnormal_peptide_metabolism	0.92082595
88	MP0009840_abnormal_foam_cell	0.90587395
89	MP0002064_seizures	0.88335398
90	MP0005389_reproductive_system_phenotype	0.86986896
91	MP0000465_gastrointestinal_hemorrhage	0.85639941
92	MP0005085_abnormal_gallbladder_physiolo	0.82856408
93	MP0001765_abnormal_ion_homeostasis	0.82011739
94	MP0002751_abnormal_autonomic_nervous	0.81017253
95	MP0004215_abnormal_myocardial_fiber	0.78200760
96	MP0000470_abnormal_stomach_morphology	0.78054892
97	MP0002139_abnormal_hepatobiliary_system	0.76352302
98	MP0002127_abnormal_cardiovascular_syste	0.76123440
99	MP0001970_abnormal_pain_threshold	0.75693462
100	MP0000230_abnormal_systemic_arterial	0.75435725

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dysdiadochokinesis (HP:0002075)	4.93427640
2	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	4.44027594
3	Gaze-evoked nystagmus (HP:0000640)	4.16491266
4	Progressive cerebellar ataxia (HP:0002073)	3.74469016
5	Anterior segment dysgenesis (HP:0007700)	3.69383485
6	Genetic anticipation (HP:0003743)	3.64900986
7	Congenital sensorineural hearing impairment (HP:0008527)	3.58635169
8	Horizontal nystagmus (HP:0000666)	3.43147918
9	Abdominal situs inversus (HP:0003363)	3.35456227
10	Abnormality of abdominal situs (HP:0011620)	3.35456227
11	Dysmetric saccades (HP:0000641)	3.34659681
12	Impulsivity (HP:0100710)	3.33668766
13	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.23679644
14	Hypophosphatemic rickets (HP:0004912)	3.12917466
15	Type II lissencephaly (HP:0007260)	3.03491723
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.02431306
17	Male infertility (HP:0003251)	2.99247958
18	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.99166033
19	Hypoplasia of the fovea (HP:0007750)	2.99166033
20	Optic nerve hypoplasia (HP:0000609)	2.95829459
21	Attenuation of retinal blood vessels (HP:0007843)	2.95233409
22	Retinal dysplasia (HP:0007973)	2.92119794
23	Abnormal respiratory motile cilium physiology (HP:0012261)	2.91366713
24	Microretrognathia (HP:0000308)	2.87107317
25	Abnormal ciliary motility (HP:0012262)	2.83950963
26	Bundle branch block (HP:0011710)	2.80576606
27	Action tremor (HP:0002345)	2.76284164
28	Abnormality of the renal cortex (HP:0011035)	2.75851410
29	Bony spicule pigmentary retinopathy (HP:0007737)	2.73885904
30	Decreased central vision (HP:0007663)	2.72571803
31	Birth length less than 3rd percentile (HP:0003561)	2.69902338
32	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.64553336
33	Rhinitis (HP:0012384)	2.62840443
34	Abnormal pancreas size (HP:0012094)	2.60316519
35	Fair hair (HP:0002286)	2.57530569
36	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.56824429
37	Congenital stationary night blindness (HP:0007642)	2.56362299
38	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.53011007
39	Esotropia (HP:0000565)	2.50359279
40	Lower limb hyperreflexia (HP:0002395)	2.46280247
41	Cerebellar dysplasia (HP:0007033)	2.45106123
42	Abnormality of the labia minora (HP:0012880)	2.43779760
43	Absent/shortened dynein arms (HP:0200106)	2.42701412
44	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.42701412
45	Infertility (HP:0000789)	2.38596910
46	Pendular nystagmus (HP:0012043)	2.38503368
47	Premature ovarian failure (HP:0008209)	2.36500723
48	Renal cortical cysts (HP:0000803)	2.36212363
49	Supernumerary spleens (HP:0009799)	2.36190698
50	Abnormality of the fovea (HP:0000493)	2.27608266
51	Chronic hepatic failure (HP:0100626)	2.24830942
52	Generalized aminoaciduria (HP:0002909)	2.22001050
53	Apathy (HP:0000741)	2.21247095
54	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.20375241
55	Pancreatic fibrosis (HP:0100732)	2.18657978
56	Urinary bladder sphincter dysfunction (HP:0002839)	2.17975780
57	Impaired smooth pursuit (HP:0007772)	2.16779545
58	Osteomalacia (HP:0002749)	2.16346593
59	Abnormal rod and cone electroretinograms (HP:0008323)	2.15999034
60	Pancreatic cysts (HP:0001737)	2.15752644
61	Bilateral sensorineural hearing impairment (HP:0008619)	2.13307489
62	Prominent supraorbital ridges (HP:0000336)	2.12777909
63	Short tibia (HP:0005736)	2.12140636
64	Septo-optic dysplasia (HP:0100842)	2.06686578
65	Protruding tongue (HP:0010808)	2.05566346
66	Hyperkalemia (HP:0002153)	2.03818362
67	Tubular atrophy (HP:0000092)	2.02492865
68	Decreased circulating renin level (HP:0003351)	2.00232365
69	Febrile seizures (HP:0002373)	1.99430161
70	Tubulointerstitial fibrosis (HP:0005576)	1.99394826
71	Hypoplasia of the brainstem (HP:0002365)	1.97164132
72	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.97164132
73	Azoospermia (HP:0000027)	1.96889519
74	Facial hemangioma (HP:0000329)	1.95236607
75	Inability to walk (HP:0002540)	1.94579610
76	Clitoromegaly (HP:0000057)	1.93299495
77	Steatorrhea (HP:0002570)	1.93054028
78	Median cleft lip (HP:0000161)	1.92629502
79	Atonic seizures (HP:0010819)	1.90247686
80	Diminished motivation (HP:0000745)	1.88793180
81	Medial flaring of the eyebrow (HP:0010747)	1.87948252
82	Retinitis pigmentosa (HP:0000510)	1.84519815
83	Oligodactyly (hands) (HP:0001180)	1.84364360
84	Thyroid-stimulating hormone excess (HP:0002925)	1.83995699
85	Abnormal auditory evoked potentials (HP:0006958)	1.83918077
86	Myokymia (HP:0002411)	1.83086542
87	Abnormality of saccadic eye movements (HP:0000570)	1.81808006
88	Hypoproteinemia (HP:0003075)	1.79091981
89	Tubulointerstitial abnormality (HP:0001969)	1.77699091
90	Retinal atrophy (HP:0001105)	1.76014424
91	Abnormality of ocular smooth pursuit (HP:0000617)	1.75806070
92	Shawl scrotum (HP:0000049)	1.74906484
93	Intellectual disability, profound (HP:0002187)	1.73379545
94	Pachygyria (HP:0001302)	1.72915261
95	Generalized hypopigmentation of hair (HP:0011358)	1.72714412
96	Dysmetria (HP:0001310)	1.72056269
97	Gait imbalance (HP:0002141)	1.71042182
98	Cystic liver disease (HP:0006706)	1.70113103
99	Abnormality of dental color (HP:0011073)	1.69330467
100	Occipital encephalocele (HP:0002085)	1.69265765

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ARAF	5.19173994
2	TAOK3	3.34305311
3	WNK4	3.30793830
4	MAP3K9	3.23620633
5	CDK19	2.93603909
6	INSRR	2.41845208
7	TNIK	2.14192042
8	PINK1	2.14174338
9	BRAF	2.06037923
10	WNK1	1.99516916
11	NEK6	1.95028827
12	RAF1	1.93426446
13	MAP3K13	1.91926684
14	FRK	1.89021770
15	BMPR1B	1.87823561
16	ZAK	1.84843623
17	MAPK13	1.81368784
18	MAP3K6	1.72917823
19	ADRBK2	1.55093763
20	BMX	1.50063184
21	PKN1	1.48469918
22	TTK	1.38156116
23	TRIM28	1.31475637
24	NME1	1.28719002
25	AURKA	1.28428082
26	MARK1	1.26614811
27	NTRK2	1.26189415
28	PLK4	1.24994359
29	GRK1	1.24144960
30	EIF2AK3	1.20363663
31	MAP3K4	1.19163104
32	PIM2	1.18678005
33	LMTK2	1.17723128
34	NEK2	1.13830035
35	STK38L	1.13750135
36	TESK2	1.13461816
37	ACVR1B	1.10221835
38	PRKCI	1.05344425
39	KDR	1.04378853
40	TLK1	1.03644973
41	NTRK3	1.01460918
42	MET	0.96498970
43	SRPK1	0.93304671
44	MARK3	0.88282030
45	MELK	0.86954530
46	MAP2K7	0.83829202
47	MOS	0.78790709
48	STK38	0.77332464
49	OBSCN	0.76048557
50	STK3	0.75917587
51	STK39	0.74939891
52	STK24	0.72374734
53	KSR2	0.71737726
54	TGFBR1	0.71514566
55	PRKCE	0.70498928
56	STK16	0.69908077
57	ADRBK1	0.66828838
58	MAP3K5	0.65847096
59	PIK3CA	0.65492412
60	TIE1	0.62955971
61	NUAK1	0.62876409
62	PRKCG	0.62629121
63	MAP2K6	0.62045563
64	PIM1	0.61731421
65	TNK2	0.60063830
66	CAMK2A	0.58598031
67	RET	0.57305416
68	CSNK1G1	0.56375876
69	PLK1	0.55412543
70	VRK1	0.55189094
71	TEC	0.55013447
72	CDK7	0.52209887
73	CHEK2	0.50515935
74	OXSR1	0.50043264
75	LATS1	0.49888141
76	PRKCQ	0.48650406
77	PTK2B	0.48354701
78	MAP2K4	0.47414329
79	MARK2	0.46250010
80	PDK1	0.46087544
81	PRKACA	0.44453119
82	CSNK1D	0.44416582
83	CDK5	0.44042483
84	PRKAA1	0.42094733
85	GRK5	0.39252615
86	EPHA3	0.39072437
87	CSNK1G3	0.38026798
88	DMPK	0.37863718
89	CSNK1G2	0.37841745
90	LIMK1	0.35791760
91	BCR	0.35120282
92	PHKG2	0.34448531
93	PHKG1	0.34448531
94	GRK7	0.34057006
95	ICK	0.33243561
96	MUSK	0.33162051
97	BRD4	0.31407669
98	PRKG1	0.31239010
99	PRKACB	0.30414688
100	PRKCA	0.29396101

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.80657696
2	Pancreatic secretion_Homo sapiens_hsa04972	3.06544036
3	Basal transcription factors_Homo sapiens_hsa03022	2.88145877
4	Nicotine addiction_Homo sapiens_hsa05033	2.85692014
5	Taste transduction_Homo sapiens_hsa04742	2.63908924
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.63511591
7	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.49089126
8	ABC transporters_Homo sapiens_hsa02010	2.30407188
9	Olfactory transduction_Homo sapiens_hsa04740	2.29731705
10	Phototransduction_Homo sapiens_hsa04744	2.17611560
11	Ovarian steroidogenesis_Homo sapiens_hsa04913	2.16704488
12	Fat digestion and absorption_Homo sapiens_hsa04975	2.05668856
13	Linoleic acid metabolism_Homo sapiens_hsa00591	2.05289670
14	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.96381063
15	GABAergic synapse_Homo sapiens_hsa04727	1.86258462
16	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.84701456
17	Oocyte meiosis_Homo sapiens_hsa04114	1.82820491
18	Butanoate metabolism_Homo sapiens_hsa00650	1.81048562
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.79608982
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.77624562
21	Morphine addiction_Homo sapiens_hsa05032	1.74623429
22	Glycerolipid metabolism_Homo sapiens_hsa00561	1.66535776
23	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.65924904
24	Protein digestion and absorption_Homo sapiens_hsa04974	1.64850658
25	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.60945955
26	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.52594364
27	beta-Alanine metabolism_Homo sapiens_hsa00410	1.49122643
28	Gap junction_Homo sapiens_hsa04540	1.43787583
29	Sulfur metabolism_Homo sapiens_hsa00920	1.43750875
30	Caffeine metabolism_Homo sapiens_hsa00232	1.41023715
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.39355114
32	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.38079155
33	Homologous recombination_Homo sapiens_hsa03440	1.37691554
34	Long-term depression_Homo sapiens_hsa04730	1.37431836
35	Calcium signaling pathway_Homo sapiens_hsa04020	1.30626728
36	Serotonergic synapse_Homo sapiens_hsa04726	1.27672172
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.23955765
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.20584335
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.18563838
40	Glutamatergic synapse_Homo sapiens_hsa04724	1.13338831
41	Bile secretion_Homo sapiens_hsa04976	1.09354357
42	Retinol metabolism_Homo sapiens_hsa00830	1.07851341
43	Ether lipid metabolism_Homo sapiens_hsa00565	1.05389386
44	RNA polymerase_Homo sapiens_hsa03020	1.04689333
45	Circadian entrainment_Homo sapiens_hsa04713	1.04279649
46	Tryptophan metabolism_Homo sapiens_hsa00380	1.01482071
47	Histidine metabolism_Homo sapiens_hsa00340	1.01454183
48	Fanconi anemia pathway_Homo sapiens_hsa03460	0.98143754
49	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.96540223
50	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.94659552
51	Circadian rhythm_Homo sapiens_hsa04710	0.94425896
52	Insulin secretion_Homo sapiens_hsa04911	0.86335312
53	Arginine and proline metabolism_Homo sapiens_hsa00330	0.85449303
54	Salivary secretion_Homo sapiens_hsa04970	0.81680034
55	Nitrogen metabolism_Homo sapiens_hsa00910	0.75273801
56	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.73639767
57	Purine metabolism_Homo sapiens_hsa00230	0.71190199
58	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.71103092
59	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.70202051
60	cAMP signaling pathway_Homo sapiens_hsa04024	0.68964946
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.68568780
62	Cholinergic synapse_Homo sapiens_hsa04725	0.67661307
63	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.61745598
64	Regulation of autophagy_Homo sapiens_hsa04140	0.61181367
65	Cell cycle_Homo sapiens_hsa04110	0.59129417
66	Mismatch repair_Homo sapiens_hsa03430	0.56093243
67	Long-term potentiation_Homo sapiens_hsa04720	0.55823945
68	Dopaminergic synapse_Homo sapiens_hsa04728	0.55094865
69	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.54819612
70	Base excision repair_Homo sapiens_hsa03410	0.52522052
71	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.52459477
72	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.51612217
73	RNA degradation_Homo sapiens_hsa03018	0.49889558
74	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.48951246
75	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.48751979
76	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.46371445
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46233523
78	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.44439977
79	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.43004178
80	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.42342906
81	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42060629
82	Arginine biosynthesis_Homo sapiens_hsa00220	0.41935641
83	Gastric acid secretion_Homo sapiens_hsa04971	0.41465923
84	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.36780770
85	Propanoate metabolism_Homo sapiens_hsa00640	0.36607616
86	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.36294014
87	RNA transport_Homo sapiens_hsa03013	0.36082955
88	Cocaine addiction_Homo sapiens_hsa05030	0.34442588
89	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.33962701
90	Amphetamine addiction_Homo sapiens_hsa05031	0.33650880
91	Steroid biosynthesis_Homo sapiens_hsa00100	0.33013574
92	Cardiac muscle contraction_Homo sapiens_hsa04260	0.31997544
93	Lysine degradation_Homo sapiens_hsa00310	0.31514770
94	Metabolic pathways_Homo sapiens_hsa01100	0.26776451
95	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.26520959
96	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.26478688
97	Phenylalanine metabolism_Homo sapiens_hsa00360	0.26389004
98	mRNA surveillance pathway_Homo sapiens_hsa03015	0.25859995
99	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.25661828
100	Chemical carcinogenesis_Homo sapiens_hsa05204	0.25637857

FAM90A12P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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