FAM90A17P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)9.76421809
2response to pheromone (GO:0019236)7.82642475
3behavioral response to nicotine (GO:0035095)7.37207764
4histone H3-K9 demethylation (GO:0033169)6.92594536
5aggressive behavior (GO:0002118)6.53402618
6positive regulation of uterine smooth muscle contraction (GO:0070474)6.44377690
7drinking behavior (GO:0042756)5.82252685
8regulation of action potential (GO:0098900)5.65282450
9tachykinin receptor signaling pathway (GO:0007217)5.30238022
10positive regulation of action potential (GO:0045760)5.28245258
11gamma-aminobutyric acid signaling pathway (GO:0007214)5.24174657
12negative regulation of nitric-oxide synthase activity (GO:0051001)5.04301104
13regulation of uterine smooth muscle contraction (GO:0070472)4.98298944
14centriole replication (GO:0007099)4.91831632
15tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.88763702
16RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.88763702
17piRNA metabolic process (GO:0034587)4.85934485
18gonadal mesoderm development (GO:0007506)4.80730289
19regulation of penile erection (GO:0060405)4.78912650
20regulation of double-strand break repair via homologous recombination (GO:0010569)4.77212748
21positive regulation of meiosis (GO:0045836)4.63716806
22positive regulation of digestive system process (GO:0060456)4.60949938
23lymph node development (GO:0048535)4.60937432
24DNA deamination (GO:0045006)4.56056873
25poly(A)+ mRNA export from nucleus (GO:0016973)4.54569697
26multicellular organism reproduction (GO:0032504)4.52126826
27embryonic skeletal joint morphogenesis (GO:0060272)4.39698979
28positive regulation of meiotic cell cycle (GO:0051446)4.36363536
29postsynaptic membrane organization (GO:0001941)4.33219454
30regulation of cellular extravasation (GO:0002691)4.25352593
31regulation of female gonad development (GO:2000194)4.20345171
32negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.11356467
33purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)4.10196875
34regulation of necroptotic process (GO:0060544)4.01495933
35DNA methylation involved in gamete generation (GO:0043046)4.01004623
36positive regulation of vascular permeability (GO:0043117)3.92483277
37regulation of acrosome reaction (GO:0060046)3.87127837
38protein K11-linked deubiquitination (GO:0035871)3.83140779
39T cell homeostasis (GO:0043029)3.82801671
40regulation of T cell mediated cytotoxicity (GO:0001914)3.79692807
41male meiosis (GO:0007140)3.67623883
42oogenesis (GO:0048477)3.60027801
43detection of light stimulus involved in visual perception (GO:0050908)3.59269813
44detection of light stimulus involved in sensory perception (GO:0050962)3.59269813
45respiratory chain complex IV assembly (GO:0008535)3.51389435
46positive regulation of renal sodium excretion (GO:0035815)3.50047068
47synaptonemal complex assembly (GO:0007130)3.47152451
48organ induction (GO:0001759)3.47013719
49type B pancreatic cell development (GO:0003323)3.41518417
50centriole assembly (GO:0098534)3.34244456
51synaptonemal complex organization (GO:0070193)3.33284736
52positive regulation of synaptic transmission, GABAergic (GO:0032230)3.30956963
53positive regulation of prostaglandin secretion (GO:0032308)3.27975258
54oocyte development (GO:0048599)3.25484270
55positive regulation of protein deacetylation (GO:0090312)3.25233156
56necroptotic process (GO:0070266)3.23511228
57activated T cell proliferation (GO:0050798)3.22044270
58regulation of retinoic acid receptor signaling pathway (GO:0048385)3.19693581
59single fertilization (GO:0007338)3.18462898
60negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.18009719
61negative regulation of monooxygenase activity (GO:0032769)3.13682456
62imidazole-containing compound metabolic process (GO:0052803)3.13257230
63male meiosis I (GO:0007141)3.12782871
64sodium-independent organic anion transport (GO:0043252)3.12708162
65urinary tract smooth muscle contraction (GO:0014848)3.09190477
66GMP metabolic process (GO:0046037)3.07834055
67positive regulation of humoral immune response (GO:0002922)3.07236838
68regulation of exit from mitosis (GO:0007096)3.05977202
69motile cilium assembly (GO:0044458)3.04193602
70regulation of cytokine production involved in inflammatory response (GO:1900015)3.03416413
71I-kappaB kinase/NF-kappaB signaling (GO:0007249)3.02224166
72maternal behavior (GO:0042711)3.00124410
73behavioral response to pain (GO:0048266)2.89832586
74regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.89514424
75regulation of female receptivity (GO:0045924)2.88018191
76endoderm development (GO:0007492)2.86122224
77regulation of posttranscriptional gene silencing (GO:0060147)2.85048650
78regulation of gene silencing by miRNA (GO:0060964)2.85048650
79regulation of gene silencing by RNA (GO:0060966)2.85048650
80negative regulation of reproductive process (GO:2000242)2.84761148
81spleen development (GO:0048536)2.84743240
82mitochondrion distribution (GO:0048311)2.81632547
83response to gravity (GO:0009629)2.79024580
84regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.77399756
85fertilization (GO:0009566)2.76586841
86signal peptide processing (GO:0006465)2.74083253
87S-adenosylmethionine metabolic process (GO:0046500)2.73866366
88reproduction (GO:0000003)2.73856000
89chemosensory behavior (GO:0007635)2.72790570
90regulation of prostaglandin secretion (GO:0032306)2.72177137
91regulation of helicase activity (GO:0051095)2.71737156
92response to inactivity (GO:0014854)2.71498020
93female gamete generation (GO:0007292)2.69030026
94regulation of receptor binding (GO:1900120)2.68290052
95regulation of rhodopsin mediated signaling pathway (GO:0022400)2.63757191
96parental behavior (GO:0060746)2.63737585
97seminiferous tubule development (GO:0072520)2.61047639
98mitotic metaphase plate congression (GO:0007080)2.58848557
99tryptophan catabolic process (GO:0006569)2.57258037
100indolalkylamine catabolic process (GO:0046218)2.57258037

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.64682786
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.87180835
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.15446444
4IGF1R_20145208_ChIP-Seq_DFB_Human4.50034612
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.15976544
6VDR_22108803_ChIP-Seq_LS180_Human2.92222485
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.59012691
8GBX2_23144817_ChIP-Seq_PC3_Human2.55532720
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.40723768
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.35875392
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.25432291
12PCGF2_27294783_Chip-Seq_NPCs_Mouse2.25000363
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.24544224
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21114162
15ZNF274_21170338_ChIP-Seq_K562_Hela2.20915760
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13135063
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.11830144
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.01591287
19TP63_19390658_ChIP-ChIP_HaCaT_Human1.97711857
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83111255
21UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.69366688
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69131269
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68039332
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.65838334
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53640750
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.51533994
27TCF4_23295773_ChIP-Seq_U87_Human1.50530587
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.50393451
29NCOR_22424771_ChIP-Seq_293T_Human1.49139418
30RUNX2_22187159_ChIP-Seq_PCA_Human1.49016925
31SOX2_19829295_ChIP-Seq_ESCs_Human1.48263127
32NANOG_19829295_ChIP-Seq_ESCs_Human1.48263127
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46754726
34TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45405320
35KLF5_20875108_ChIP-Seq_MESCs_Mouse1.43588754
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43263134
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42431775
38IRF1_19129219_ChIP-ChIP_H3396_Human1.41747620
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.40669609
40SMAD4_21799915_ChIP-Seq_A2780_Human1.39644162
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39267241
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36552082
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36263086
44TP53_20018659_ChIP-ChIP_R1E_Mouse1.35221070
45TAF15_26573619_Chip-Seq_HEK293_Human1.34128522
46P300_19829295_ChIP-Seq_ESCs_Human1.33845824
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.31499648
48FOXH1_21741376_ChIP-Seq_EPCs_Human1.31403700
49PRDM14_20953172_ChIP-Seq_ESCs_Human1.31042136
50REST_21632747_ChIP-Seq_MESCs_Mouse1.30975164
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28742233
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28719907
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24490587
54TAF2_19829295_ChIP-Seq_ESCs_Human1.23184741
55CBP_20019798_ChIP-Seq_JUKART_Human1.22873331
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22873331
57HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.22684526
58BCAT_22108803_ChIP-Seq_LS180_Human1.22467222
59STAT3_23295773_ChIP-Seq_U87_Human1.21948885
60SOX2_21211035_ChIP-Seq_LN229_Human1.20989430
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20209976
62AR_25329375_ChIP-Seq_VCAP_Human1.19967611
63CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.18924011
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.18356931
65TCF4_22108803_ChIP-Seq_LS180_Human1.18047723
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15611965
67NANOG_20526341_ChIP-Seq_ESCs_Human1.14042987
68PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11138234
69TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.09074562
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08910126
71OCT4_20526341_ChIP-Seq_ESCs_Human1.08089204
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07672847
73TP53_22573176_ChIP-Seq_HFKS_Human1.07616214
74SMAD4_21741376_ChIP-Seq_EPCs_Human1.07472092
75RNF2_27304074_Chip-Seq_NSC_Mouse1.05393814
76AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05250172
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03123086
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02083463
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01168906
80DROSHA_22980978_ChIP-Seq_HELA_Human0.98976111
81AR_20517297_ChIP-Seq_VCAP_Human0.97291293
82YY1_21170310_ChIP-Seq_MESCs_Mouse0.97177069
83HOXB7_26014856_ChIP-Seq_BT474_Human0.95480152
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94734435
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94480402
86CRX_20693478_ChIP-Seq_RETINA_Mouse0.94216887
87EZH2_27294783_Chip-Seq_NPCs_Mouse0.94175133
88SUZ12_27294783_Chip-Seq_ESCs_Mouse0.92428269
89CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.92241540
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92133967
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90362884
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89654062
93RAC3_21632823_ChIP-Seq_H3396_Human0.88613610
94STAT1_17558387_ChIP-Seq_HELA_Human0.87277247
95FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87080638
96MYC_19829295_ChIP-Seq_ESCs_Human0.85844125
97RXR_22108803_ChIP-Seq_LS180_Human0.85782087
98EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.84737837
99RNF2_18974828_ChIP-Seq_MESCs_Mouse0.83245163
100EZH2_18974828_ChIP-Seq_MESCs_Mouse0.83245163

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.70816075
2MP0000372_irregular_coat_pigmentation4.69077843
3MP0003283_abnormal_digestive_organ3.62978772
4MP0002163_abnormal_gland_morphology3.31201285
5MP0006292_abnormal_olfactory_placode3.04580308
6MP0001968_abnormal_touch/_nociception2.89570258
7MP0002736_abnormal_nociception_after2.88427227
8MP0002277_abnormal_respiratory_mucosa2.82172160
9MP0008877_abnormal_DNA_methylation2.79797938
10MP0006082_CNS_inflammation2.60337906
11MP0003183_abnormal_peptide_metabolism2.51363080
12MP0005423_abnormal_somatic_nervous2.49072771
13MP0001764_abnormal_homeostasis2.48113198
14MP0005671_abnormal_response_to2.31773623
15MP0002132_abnormal_respiratory_system2.27870250
16MP0009379_abnormal_foot_pigmentation2.21212081
17MP0005646_abnormal_pituitary_gland2.11943355
18MP0005410_abnormal_fertilization2.01414015
19MP0003646_muscle_fatigue1.97078198
20MP0008057_abnormal_DNA_replication1.96415059
21MP0001986_abnormal_taste_sensitivity1.94486215
22MP0005083_abnormal_biliary_tract1.85691028
23MP0005379_endocrine/exocrine_gland_phen1.78016277
24MP0003950_abnormal_plasma_membrane1.77207474
25MP0001661_extended_life_span1.69957692
26MP0005551_abnormal_eye_electrophysiolog1.68856534
27MP0001529_abnormal_vocalization1.68056042
28MP0009384_cardiac_valve_regurgitation1.67999377
29MP0010368_abnormal_lymphatic_system1.61027666
30MP0002210_abnormal_sex_determination1.58575541
31MP0004142_abnormal_muscle_tone1.55206404
32MP0003866_abnormal_defecation1.54076714
33MP0000013_abnormal_adipose_tissue1.51300273
34MP0002734_abnormal_mechanical_nocicepti1.49875088
35MP0001929_abnormal_gametogenesis1.49702425
36MP0002234_abnormal_pharynx_morphology1.47568957
37MP0008874_decreased_physiological_sensi1.45481240
38MP0003252_abnormal_bile_duct1.43854960
39MP0005220_abnormal_exocrine_pancreas1.43275126
40MP0002160_abnormal_reproductive_system1.43218852
41MP0000685_abnormal_immune_system1.42091799
42MP0002735_abnormal_chemical_nociception1.41717472
43MP0004019_abnormal_vitamin_homeostasis1.40766815
44MP0005253_abnormal_eye_physiology1.39984514
45MP0005075_abnormal_melanosome_morpholog1.32227847
46MP0008995_early_reproductive_senescence1.28496630
47MP0006276_abnormal_autonomic_nervous1.27224584
48MP0003699_abnormal_female_reproductive1.22448393
49MP0000631_abnormal_neuroendocrine_gland1.21310535
50MP0005647_abnormal_sex_gland1.20962690
51MP0010386_abnormal_urinary_bladder1.19372562
52MP0004133_heterotaxia1.18520655
53MP0000678_abnormal_parathyroid_gland1.15708629
54MP0002272_abnormal_nervous_system1.14282025
55MP0001502_abnormal_circadian_rhythm1.13696465
56MP0000653_abnormal_sex_gland1.10368836
57MP0008872_abnormal_physiological_respon1.06170074
58MP0003656_abnormal_erythrocyte_physiolo1.06015574
59MP0002933_joint_inflammation1.05947800
60MP0009745_abnormal_behavioral_response1.04171739
61MP0003763_abnormal_thymus_physiology1.02365798
62MP0001664_abnormal_digestion1.01722069
63MP0004043_abnormal_pH_regulation1.00534842
64MP0001145_abnormal_male_reproductive0.99286067
65MP0003119_abnormal_digestive_system0.97507870
66MP0010307_abnormal_tumor_latency0.96322207
67MP0002693_abnormal_pancreas_physiology0.96221244
68MP0001501_abnormal_sleep_pattern0.95269191
69MP0003698_abnormal_male_reproductive0.94469358
70MP0004381_abnormal_hair_follicle0.91084978
71MP0005389_reproductive_system_phenotype0.88932133
72MP0005376_homeostasis/metabolism_phenot0.86783887
73MP0002161_abnormal_fertility/fecundity0.84799476
74MP0001119_abnormal_female_reproductive0.84504495
75MP0003690_abnormal_glial_cell0.84457474
76MP0004130_abnormal_muscle_cell0.84314401
77MP0005391_vision/eye_phenotype0.83372590
78MP0002557_abnormal_social/conspecific_i0.82648229
79MP0001944_abnormal_pancreas_morphology0.80744271
80MP0000428_abnormal_craniofacial_morphol0.79464654
81MP0006072_abnormal_retinal_apoptosis0.75967744
82MP0005266_abnormal_metabolism0.74892793
83MP0002572_abnormal_emotion/affect_behav0.74768395
84MP0002396_abnormal_hematopoietic_system0.73140845
85MP0005334_abnormal_fat_pad0.71437166
86MP0002067_abnormal_sensory_capabilities0.70886015
87MP0000427_abnormal_hair_cycle0.69472744
88MP0001440_abnormal_grooming_behavior0.68140445
89MP0002928_abnormal_bile_duct0.67673216
90MP0002751_abnormal_autonomic_nervous0.66695134
91MP0005360_urolithiasis0.65994485
92MP0002229_neurodegeneration0.65951973
93MP0000026_abnormal_inner_ear0.63853646
94MP0001324_abnormal_eye_pigmentation0.62432727
95MP0000003_abnormal_adipose_tissue0.61623826
96MP0010329_abnormal_lipoprotein_level0.61486389
97MP0004084_abnormal_cardiac_muscle0.61153685
98MP0003718_maternal_effect0.61115842
99MP0001963_abnormal_hearing_physiology0.61036587
100MP0003635_abnormal_synaptic_transmissio0.61006418

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the pons (HP:0007361)6.00338258
2Hypoplasia of the pons (HP:0012110)5.69702241
3Hyperlipoproteinemia (HP:0010980)4.27970803
4J-shaped sella turcica (HP:0002680)4.23517022
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.08496779
6Abnormality of the vertebral endplates (HP:0005106)3.72182008
7Cerebral palsy (HP:0100021)3.59159031
8Biconcave vertebral bodies (HP:0004586)3.57708648
9Abnormality of the femoral head (HP:0003368)3.44924527
10Pancreatic fibrosis (HP:0100732)3.25834858
11Autoimmune hemolytic anemia (HP:0001890)3.20954679
12Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.11118586
13Aplasia/Hypoplasia of the fovea (HP:0008060)3.00042261
14Hypoplasia of the fovea (HP:0007750)3.00042261
15Hypoplasia of the odontoid process (HP:0003311)2.98665157
16Absent/shortened dynein arms (HP:0200106)2.94711638
17Dynein arm defect of respiratory motile cilia (HP:0012255)2.94711638
18Hypoproteinemia (HP:0003075)2.90534800
19Enlarged epiphyses (HP:0010580)2.85136873
20Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.78132161
21Broad face (HP:0000283)2.76175495
22Abnormality of the epiphysis of the femoral head (HP:0010574)2.73366318
23Nonprogressive disorder (HP:0003680)2.73288948
24Nasal polyposis (HP:0100582)2.71217841
25Ulnar claw (HP:0001178)2.69994063
26Autoimmune thrombocytopenia (HP:0001973)2.66311884
27Irregular epiphyses (HP:0010582)2.63702438
28Dyskinesia (HP:0100660)2.62293955
29Flared iliac wings (HP:0002869)2.60781462
30Congenital stationary night blindness (HP:0007642)2.60599479
31Poor suck (HP:0002033)2.57616634
32Atonic seizures (HP:0010819)2.55980099
33Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.51145427
34Opisthotonus (HP:0002179)2.50017754
35Impaired smooth pursuit (HP:0007772)2.49228698
36Obstructive sleep apnea (HP:0002870)2.48626003
37Abnormality of femoral epiphyses (HP:0006499)2.46400550
38Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.46400550
39Hypoplasia of the capital femoral epiphysis (HP:0003090)2.42209438
40Epidermoid cyst (HP:0200040)2.41523267
41Periodontitis (HP:0000704)2.38271498
42Abnormality of the odontoid process (HP:0003310)2.34829135
43Hypoplasia of the iris (HP:0007676)2.32192499
44Death in childhood (HP:0003819)2.29754597
45Medial flaring of the eyebrow (HP:0010747)2.28268481
46Abnormal respiratory motile cilium physiology (HP:0012261)2.28223904
47Asplenia (HP:0001746)2.26706012
48Abnormal ciliary motility (HP:0012262)2.25401396
49Carpal bone hypoplasia (HP:0001498)2.22913801
50Attenuation of retinal blood vessels (HP:0007843)2.19738145
51Abnormality of the fovea (HP:0000493)2.18616033
52Type 2 muscle fiber atrophy (HP:0003554)2.18552870
53Subaortic stenosis (HP:0001682)2.17513682
54Abnormality of the left ventricular outflow tract (HP:0011103)2.17513682
55Abnormality of the renal collecting system (HP:0004742)2.16175164
56Spinal canal stenosis (HP:0003416)2.15676280
57Flat capital femoral epiphysis (HP:0003370)2.14696152
58Encephalitis (HP:0002383)2.11077970
59Joint stiffness (HP:0001387)2.10558068
60Premature ovarian failure (HP:0008209)2.08207132
61Abnormality of the nasal mucosa (HP:0000433)2.07923397
62Disproportionate short-trunk short stature (HP:0003521)2.07285875
63Aplasia/Hypoplasia of the macula (HP:0008059)2.05459012
64Growth hormone excess (HP:0000845)2.04157108
65Bony spicule pigmentary retinopathy (HP:0007737)2.03896245
66Central scotoma (HP:0000603)2.02821266
67Constricted visual fields (HP:0001133)2.01933622
68Aplasia/Hypoplasia of the spleen (HP:0010451)2.00841474
69Aplasia/hypoplasia of the femur (HP:0005613)2.00586018
70Deformed sella turcica (HP:0002681)2.00273027
71Genu varum (HP:0002970)2.00242211
72Aplasia/Hypoplasia of the tibia (HP:0005772)1.99609133
73Abnormality of ocular smooth pursuit (HP:0000617)1.96338502
74Aplasia/Hypoplasia of the tongue (HP:0010295)1.96240463
75Increased serum ferritin (HP:0003281)1.95419334
76Decreased subcutaneous fat (HP:0001002)1.94691503
77Oligodactyly (hands) (HP:0001180)1.94015295
78Aplasia/Hypoplasia affecting the retina (HP:0008061)1.93813099
79Genital tract atresia (HP:0001827)1.92250990
80Fair hair (HP:0002286)1.90277216
81Thyroiditis (HP:0100646)1.89252086
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87688074
83Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.87037875
84Absent epiphyses (HP:0010577)1.87037875
85Duplicated collecting system (HP:0000081)1.86612330
86True hermaphroditism (HP:0010459)1.86021459
87Asthma (HP:0002099)1.85395051
88Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.85211209
89Median cleft lip (HP:0000161)1.84082265
90Oligomenorrhea (HP:0000876)1.83585182
91Irregular vertebral endplates (HP:0003301)1.82302456
92Submucous cleft hard palate (HP:0000176)1.82241434
93Abnormality of the wing of the ilium (HP:0011867)1.81310410
94Abnormality of DNA repair (HP:0003254)1.79917208
95Abnormality of the periventricular white matter (HP:0002518)1.79749212
96Gait imbalance (HP:0002141)1.79745704
97Supernumerary spleens (HP:0009799)1.78652267
98Hemiplegia (HP:0002301)1.78603812
99Cervical subluxation (HP:0003308)1.77564658
100Short tibia (HP:0005736)1.76252838

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.24790885
2EPHA43.98678492
3PRPF4B3.52157495
4DAPK23.29134177
5VRK23.10010960
6BLK2.64471500
7MELK2.46629584
8TRPM72.45891729
9FRK2.44776818
10MAP3K112.13895103
11MAP3K51.96904520
12RIPK41.89338294
13STK381.81758131
14BMPR1B1.80149029
15TIE11.78018924
16TAOK21.71849243
17DAPK11.71080980
18VRK11.69440532
19TXK1.61526650
20CAMK41.61121906
21ITK1.56325216
22YES11.55592171
23AURKA1.49474032
24STK161.43779013
25EIF2AK31.36391645
26STK41.30089098
27FES1.28790370
28PKN11.14996868
29GRK11.08587064
30TNK21.06540466
31CAMKK21.04438855
32CDK191.02164572
33WNK11.01600568
34PRKD31.01455100
35MAPK131.00656038
36TNIK0.99159199
37RPS6KB10.98349431
38RET0.97030286
39DYRK1B0.96971460
40CDK120.96690091
41NUAK10.95759224
42UHMK10.94822427
43CSF1R0.92903590
44CAMK10.90927662
45PNCK0.86619945
46PLK40.85569417
47ACVR1B0.83824154
48GSK3A0.83100002
49PIM10.82865312
50TGFBR10.81587106
51ZAK0.79585263
52PDK10.79164723
53ZAP700.75704608
54DYRK20.74055190
55MKNK20.73429565
56MAP3K70.71284530
57MARK20.67786122
58HCK0.67169105
59LYN0.67043269
60WNK30.64580890
61DAPK30.64178213
62MAP4K10.64155888
63CDK80.62538069
64PRKD20.62064416
65EIF2AK20.59802591
66PDPK10.58897455
67ERBB30.58810341
68IRAK10.56690997
69FGR0.56125002
70SGK10.55682981
71NEK90.55515688
72OXSR10.53573083
73ADRBK20.52199075
74ADRBK10.51574111
75CAMK2A0.48648576
76PRKCZ0.48577938
77PRKCQ0.48030811
78EPHB10.47892892
79DYRK30.47642418
80TEC0.47559216
81TESK20.45525539
82MAP3K30.42638929
83PTK2B0.42224505
84SYK0.41726234
85MAP2K30.39772167
86IGF1R0.38968132
87ABL10.38849274
88RPS6KA50.38774709
89PRKCG0.38476317
90PRKAA10.36913010
91ERBB40.35590930
92TLK10.34901276
93TAOK30.34897503
94FLT30.34642138
95PRKCH0.34312656
96CDK60.33903548
97INSRR0.33004961
98RPS6KA60.32866301
99PRKG10.31727018
100SGK2230.31381269

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.39857625
2Nicotine addiction_Homo sapiens_hsa050334.13420224
3Phototransduction_Homo sapiens_hsa047443.97968834
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.19882844
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.67785897
6ABC transporters_Homo sapiens_hsa020102.41529069
7Primary immunodeficiency_Homo sapiens_hsa053402.34927403
8Morphine addiction_Homo sapiens_hsa050322.16816510
9Olfactory transduction_Homo sapiens_hsa047402.11538439
10SNARE interactions in vesicular transport_Homo sapiens_hsa041302.10310154
11GABAergic synapse_Homo sapiens_hsa047272.08438532
12Dorso-ventral axis formation_Homo sapiens_hsa043202.05895582
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.02328490
14Ribosome_Homo sapiens_hsa030101.92407819
15Basal transcription factors_Homo sapiens_hsa030221.87422318
16Vitamin B6 metabolism_Homo sapiens_hsa007501.80391721
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67530803
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.58317135
19Regulation of autophagy_Homo sapiens_hsa041401.55712193
20Histidine metabolism_Homo sapiens_hsa003401.47233306
21Huntingtons disease_Homo sapiens_hsa050161.45835233
22Proteasome_Homo sapiens_hsa030501.34342869
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32831347
24Linoleic acid metabolism_Homo sapiens_hsa005911.29717060
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.21653579
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.19260475
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17157100
28Oxidative phosphorylation_Homo sapiens_hsa001901.16544959
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15173852
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14550421
31Retinol metabolism_Homo sapiens_hsa008301.10374000
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06913822
33Fanconi anemia pathway_Homo sapiens_hsa034601.05785529
34Caffeine metabolism_Homo sapiens_hsa002321.05080297
35Hematopoietic cell lineage_Homo sapiens_hsa046401.04689460
36Insulin secretion_Homo sapiens_hsa049111.01809337
37Chemical carcinogenesis_Homo sapiens_hsa052040.98295137
38Homologous recombination_Homo sapiens_hsa034400.93909165
39Glutamatergic synapse_Homo sapiens_hsa047240.92202225
40Bile secretion_Homo sapiens_hsa049760.92144437
41Calcium signaling pathway_Homo sapiens_hsa040200.91464718
42Synaptic vesicle cycle_Homo sapiens_hsa047210.90714198
43Glycerolipid metabolism_Homo sapiens_hsa005610.85337693
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84287859
45Antigen processing and presentation_Homo sapiens_hsa046120.84001828
46Taste transduction_Homo sapiens_hsa047420.82977812
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81592352
48Ovarian steroidogenesis_Homo sapiens_hsa049130.79556674
49Sulfur relay system_Homo sapiens_hsa041220.75203784
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75098312
51RNA degradation_Homo sapiens_hsa030180.74131628
52Parkinsons disease_Homo sapiens_hsa050120.73579047
53Graft-versus-host disease_Homo sapiens_hsa053320.72572511
54Cardiac muscle contraction_Homo sapiens_hsa042600.69770374
55Amphetamine addiction_Homo sapiens_hsa050310.69659650
56Systemic lupus erythematosus_Homo sapiens_hsa053220.67680697
57Fatty acid biosynthesis_Homo sapiens_hsa000610.67518056
58Renin secretion_Homo sapiens_hsa049240.67398193
59Salivary secretion_Homo sapiens_hsa049700.67071526
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64899051
61Alzheimers disease_Homo sapiens_hsa050100.64051889
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62849423
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61757573
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61468198
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60452063
66Circadian entrainment_Homo sapiens_hsa047130.57802488
67T cell receptor signaling pathway_Homo sapiens_hsa046600.55647157
68Ether lipid metabolism_Homo sapiens_hsa005650.55437675
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53839461
70Protein digestion and absorption_Homo sapiens_hsa049740.53239693
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52996434
72RNA polymerase_Homo sapiens_hsa030200.47750309
73TNF signaling pathway_Homo sapiens_hsa046680.45314209
74Arachidonic acid metabolism_Homo sapiens_hsa005900.45078778
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43500242
76African trypanosomiasis_Homo sapiens_hsa051430.43042201
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42666438
78Measles_Homo sapiens_hsa051620.40057363
79PPAR signaling pathway_Homo sapiens_hsa033200.39328740
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39150775
81Autoimmune thyroid disease_Homo sapiens_hsa053200.39105257
82Tryptophan metabolism_Homo sapiens_hsa003800.39048194
83Shigellosis_Homo sapiens_hsa051310.38146542
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.37821618
85Cholinergic synapse_Homo sapiens_hsa047250.37306346
86Nitrogen metabolism_Homo sapiens_hsa009100.35790297
87Oocyte meiosis_Homo sapiens_hsa041140.35514464
88Insulin resistance_Homo sapiens_hsa049310.33571773
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.33392094
90Alcoholism_Homo sapiens_hsa050340.31631834
91One carbon pool by folate_Homo sapiens_hsa006700.30282382
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28502968
93Pancreatic secretion_Homo sapiens_hsa049720.27710280
94Renin-angiotensin system_Homo sapiens_hsa046140.27492626
95Allograft rejection_Homo sapiens_hsa053300.27243729
96Glucagon signaling pathway_Homo sapiens_hsa049220.26009656
97Mineral absorption_Homo sapiens_hsa049780.24985368
98Serotonergic synapse_Homo sapiens_hsa047260.24172851
99FoxO signaling pathway_Homo sapiens_hsa040680.24071498
100Tyrosine metabolism_Homo sapiens_hsa003500.23460514

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