ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	8.71345712
2	histone H3-K9 demethylation (GO:0033169)	7.88315671
3	glycine transport (GO:0015816)	7.63728219
4	regulation of acrosome reaction (GO:0060046)	7.55147796
5	regulation of female gonad development (GO:2000194)	7.51844887
6	regulation of retinoic acid receptor signaling pathway (GO:0048385)	7.36702628
7	positive regulation of uterine smooth muscle contraction (GO:0070474)	7.16677901
8	positive regulation of histone H3-K4 methylation (GO:0051571)	7.04937386
9	piRNA metabolic process (GO:0034587)	6.77561577
10	regulation of DNA methylation (GO:0044030)	6.47848698
11	multicellular organism reproduction (GO:0032504)	6.36389648
12	meiotic cell cycle (GO:0051321)	6.33113268
13	regulation of G0 to G1 transition (GO:0070316)	6.07680622
14	oocyte development (GO:0048599)	6.06365928
15	regulation of histone H3-K9 methylation (GO:0051570)	5.92597317
16	retinal cone cell development (GO:0046549)	5.90702296
17	regulation of female receptivity (GO:0045924)	5.69522354
18	regulation of uterine smooth muscle contraction (GO:0070472)	5.38597475
19	phosphorelay signal transduction system (GO:0000160)	5.37765081
20	positive regulation of meiosis (GO:0045836)	5.31121324
21	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	5.18674836
22	L-amino acid import (GO:0043092)	5.04415417
23	positive regulation of meiotic cell cycle (GO:0051446)	5.01514349
24	gonadal mesoderm development (GO:0007506)	4.91063348
25	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	4.90982854
26	female mating behavior (GO:0060180)	4.74841146
27	hyperosmotic salinity response (GO:0042538)	4.63515254
28	regulation of meiosis I (GO:0060631)	4.62415948
29	DNA methylation involved in gamete generation (GO:0043046)	4.57812481
30	negative regulation of histone methylation (GO:0031061)	4.56801443
31	positive regulation of gastrulation (GO:2000543)	4.50858741
32	sleep (GO:0030431)	4.41359862
33	aggressive behavior (GO:0002118)	4.38277422
34	protein kinase C signaling (GO:0070528)	4.38131325
35	cellular response to pH (GO:0071467)	4.34761811
36	negative regulation of digestive system process (GO:0060457)	4.34742125
37	negative regulation of reproductive process (GO:2000242)	4.23417417
38	positive regulation of reproductive process (GO:2000243)	4.20715895
39	single fertilization (GO:0007338)	4.16837074
40	reproduction (GO:0000003)	4.15094331
41	positive regulation of prostaglandin secretion (GO:0032308)	4.13683758
42	synaptonemal complex assembly (GO:0007130)	4.12917460
43	regulation of steroid hormone secretion (GO:2000831)	4.06564332
44	positive regulation of digestive system process (GO:0060456)	4.04177197
45	positive regulation of catecholamine secretion (GO:0033605)	4.02729203
46	N-terminal protein amino acid acetylation (GO:0006474)	3.94026223
47	regulation of cell maturation (GO:1903429)	3.92603981
48	regulation of penile erection (GO:0060405)	3.90953418
49	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.90259690
50	regulation of meiosis (GO:0040020)	3.89541031
51	synaptonemal complex organization (GO:0070193)	3.86685227
52	regulation of histone H3-K4 methylation (GO:0051569)	3.86587378
53	drinking behavior (GO:0042756)	3.84473206
54	gene silencing by RNA (GO:0031047)	3.77714750
55	regulation of exit from mitosis (GO:0007096)	3.76786738
56	regulation of steroid hormone biosynthetic process (GO:0090030)	3.74782463
57	DNA replication-dependent nucleosome assembly (GO:0006335)	3.74624658
58	DNA replication-dependent nucleosome organization (GO:0034723)	3.74624658
59	male meiosis I (GO:0007141)	3.73961106
60	negative regulation of hormone biosynthetic process (GO:0032353)	3.68092278
61	male meiosis (GO:0007140)	3.67627918
62	amino acid import (GO:0043090)	3.60822332
63	negative regulation of hormone metabolic process (GO:0032351)	3.52706993
64	fertilization (GO:0009566)	3.48562431
65	positive regulation of histone methylation (GO:0031062)	3.44252417
66	positive regulation of humoral immune response (GO:0002922)	3.43576118
67	regulation of meiotic cell cycle (GO:0051445)	3.36488759
68	positive regulation of endothelial cell differentiation (GO:0045603)	3.34898391
69	regulation of prostaglandin secretion (GO:0032306)	3.33036448
70	response to acidic pH (GO:0010447)	3.30909041
71	type B pancreatic cell development (GO:0003323)	3.28719078
72	DNA alkylation (GO:0006305)	3.27000664
73	DNA methylation (GO:0006306)	3.27000664
74	citrulline biosynthetic process (GO:0019240)	3.23143672
75	histone lysine demethylation (GO:0070076)	3.19843884
76	gamma-aminobutyric acid transport (GO:0015812)	3.18783142
77	chromosome organization involved in meiosis (GO:0070192)	3.18065979
78	gene silencing (GO:0016458)	3.17101914
79	regulation of calcium ion-dependent exocytosis (GO:0017158)	3.05834390
80	regulation of reproductive process (GO:2000241)	3.04521756
81	cilium or flagellum-dependent cell motility (GO:0001539)	3.03824599
82	meiosis I (GO:0007127)	3.03474872
83	positive regulation of icosanoid secretion (GO:0032305)	3.03306682
84	chromatin assembly (GO:0031497)	3.00848873
85	negative regulation of histone modification (GO:0031057)	2.99003658
86	histone demethylation (GO:0016577)	2.98659308
87	microtubule severing (GO:0051013)	2.98270857
88	binding of sperm to zona pellucida (GO:0007339)	2.97266095
89	synapsis (GO:0007129)	2.93049709
90	positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)	2.92980404
91	positive regulation of steroid hormone secretion (GO:2000833)	2.90903440
92	positive regulation of fatty acid transport (GO:2000193)	2.90753592
93	detection of light stimulus involved in sensory perception (GO:0050962)	2.87723404
94	detection of light stimulus involved in visual perception (GO:0050908)	2.87723404
95	sperm-egg recognition (GO:0035036)	2.84424441
96	L-fucose catabolic process (GO:0042355)	2.82443704
97	fucose catabolic process (GO:0019317)	2.82443704
98	L-fucose metabolic process (GO:0042354)	2.82443704
99	cochlea development (GO:0090102)	2.82391275
100	meiotic nuclear division (GO:0007126)	2.82015078

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.42106269
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.65937376
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.30442078
4	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.70566873
5	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.58789082
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.48746816
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.30630804
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.24453933
9	DROSHA_22980978_ChIP-Seq_HELA_Human	2.22660406
10	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.20230523
11	VDR_22108803_ChIP-Seq_LS180_Human	2.05222656
12	EZH2_22144423_ChIP-Seq_EOC_Human	12.0592975
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.91254906
14	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.87685060
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.80932346
16	AR_25329375_ChIP-Seq_VCAP_Human	1.63145720
17	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.62938136
18	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.62938136
19	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.62938136
20	TCF4_23295773_ChIP-Seq_U87_Human	1.61626650
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.57539692
22	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.56774606
23	STAT3_23295773_ChIP-Seq_U87_Human	1.56587909
24	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.52373872
25	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.50569536
26	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.49954613
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.48572433
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.46808858
29	ZNF274_21170338_ChIP-Seq_K562_Hela	1.44057801
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.42619203
31	REST_21632747_ChIP-Seq_MESCs_Mouse	1.41824649
32	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.41753590
33	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.41663689
34	RUNX2_22187159_ChIP-Seq_PCA_Human	1.37663499
35	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.34540524
36	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.32856058
37	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.32414502
38	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32040714
39	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.31033690
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.29316494
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29316494
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.28589469
43	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.28105249
44	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.28082233
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.26854935
46	RXR_22108803_ChIP-Seq_LS180_Human	1.24987458
47	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.23824700
48	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.19654218
49	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.15925716
50	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.14916896
51	CBP_21632823_ChIP-Seq_H3396_Human	1.14148075
52	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.13740526
53	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.12993959
54	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.11511780
55	TAF15_26573619_Chip-Seq_HEK293_Human	1.11090674
56	RNF2_27304074_Chip-Seq_NSC_Mouse	1.11006476
57	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.08361304
58	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07665872
59	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.06764347
60	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.06425083
61	NANOG_20526341_ChIP-Seq_ESCs_Human	1.06309153
62	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05820786
63	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.05438015
64	P300_19829295_ChIP-Seq_ESCs_Human	1.05304648
65	ER_23166858_ChIP-Seq_MCF-7_Human	1.04283364
66	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03319875
67	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.03319875
68	SMRT_27268052_Chip-Seq_Bcells_Human	1.03132140
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.03025929
70	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02218703
71	AHR_22903824_ChIP-Seq_MCF-7_Human	1.01934887
72	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.00901079
73	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.00127970
74	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.99958082
75	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.99894338
76	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.99041953
77	GF1_26923725_Chip-Seq_HPCs_Mouse	0.98644901
78	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.98562624
79	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.98460017
80	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.97482607
81	NCOR_22424771_ChIP-Seq_293T_Human	0.97452649
82	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97048495
83	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.95172573
84	KLF4_19829295_ChIP-Seq_ESCs_Human	0.95004843
85	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.94407666
86	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.94122339
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.93268256
88	CTCF_20526341_ChIP-Seq_ESCs_Human	0.92844612
89	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92649264
90	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.91498094
91	TP53_22573176_ChIP-Seq_HFKS_Human	0.91447216
92	OCT4_19829295_ChIP-Seq_ESCs_Human	0.91293493
93	TAF2_19829295_ChIP-Seq_ESCs_Human	0.91022259
94	AR_19668381_ChIP-Seq_PC3_Human	0.89764533
95	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.89595409
96	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.89595409
97	OCT4_20526341_ChIP-Seq_ESCs_Human	0.88980097
98	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.88808385
99	IGF1R_20145208_ChIP-Seq_DFB_Human	0.87746983
100	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.87088092

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.00778153
2	MP0003718_maternal_effect	4.07098956
3	MP0003879_abnormal_hair_cell	3.58911905
4	MP0003136_yellow_coat_color	3.19520319
5	MP0008789_abnormal_olfactory_epithelium	3.02329793
6	MP0003693_abnormal_embryo_hatching	2.92245208
7	MP0005499_abnormal_olfactory_system	2.89161619
8	MP0005394_taste/olfaction_phenotype	2.89161619
9	MP0008877_abnormal_DNA_methylation	2.71001615
10	MP0010030_abnormal_orbit_morphology	2.65785552
11	MP0009379_abnormal_foot_pigmentation	2.56033644
12	MP0000427_abnormal_hair_cycle	2.31262085
13	MP0002160_abnormal_reproductive_system	2.26806503
14	MP0008057_abnormal_DNA_replication	2.15095790
15	MP0000566_synostosis	2.14329171
16	MP0005410_abnormal_fertilization	2.08448999
17	MP0006276_abnormal_autonomic_nervous	2.07873896
18	MP0009840_abnormal_foam_cell	2.02728324
19	MP0001664_abnormal_digestion	2.02390019
20	MP0001929_abnormal_gametogenesis	1.99990505
21	MP0003950_abnormal_plasma_membrane	1.89926991
22	MP0004043_abnormal_pH_regulation	1.87951244
23	MP0002272_abnormal_nervous_system	1.83312935
24	MP0003878_abnormal_ear_physiology	1.83227025
25	MP0005377_hearing/vestibular/ear_phenot	1.83227025
26	MP0003699_abnormal_female_reproductive	1.81725424
27	MP0002138_abnormal_hepatobiliary_system	1.80449520
28	MP0000678_abnormal_parathyroid_gland	1.80305237
29	MP0005646_abnormal_pituitary_gland	1.79966047
30	MP0001666_abnormal_nutrient_absorption	1.75086580
31	MP0002210_abnormal_sex_determination	1.75009218
32	MP0000631_abnormal_neuroendocrine_gland	1.70746981
33	MP0005551_abnormal_eye_electrophysiolog	1.70515076
34	MP0003890_abnormal_embryonic-extraembry	1.68046172
35	MP0001502_abnormal_circadian_rhythm	1.65099353
36	MP0000049_abnormal_middle_ear	1.63957105
37	MP0004142_abnormal_muscle_tone	1.61713703
38	MP0002102_abnormal_ear_morphology	1.59529047
39	MP0005395_other_phenotype	1.51119661
40	MP0008058_abnormal_DNA_repair	1.50738971
41	MP0005360_urolithiasis	1.47234624
42	MP0002234_abnormal_pharynx_morphology	1.45789575
43	MP0001485_abnormal_pinna_reflex	1.40150739
44	MP0001963_abnormal_hearing_physiology	1.37500964
45	MP0001501_abnormal_sleep_pattern	1.36570120
46	MP0001984_abnormal_olfaction	1.34887531
47	MP0001486_abnormal_startle_reflex	1.31416184
48	MP0000465_gastrointestinal_hemorrhage	1.30192474
49	MP0003183_abnormal_peptide_metabolism	1.29950760
50	MP0002161_abnormal_fertility/fecundity	1.29760948
51	MP0003698_abnormal_male_reproductive	1.27213682
52	MP0000653_abnormal_sex_gland	1.24512564
53	MP0000026_abnormal_inner_ear	1.22641188
54	MP0002249_abnormal_larynx_morphology	1.21214083
55	MP0003195_calcinosis	1.19938373
56	MP0003866_abnormal_defecation	1.18471978
57	MP0002734_abnormal_mechanical_nocicepti	1.12444742
58	MP0003121_genomic_imprinting	1.10102306
59	MP0002139_abnormal_hepatobiliary_system	1.09948844
60	MP0001986_abnormal_taste_sensitivity	1.09447070
61	MP0003119_abnormal_digestive_system	1.08507710
62	MP0010368_abnormal_lymphatic_system	1.06836438
63	MP0002751_abnormal_autonomic_nervous	1.06658030
64	MP0005389_reproductive_system_phenotype	1.05030997
65	MP0001119_abnormal_female_reproductive	0.98804277
66	MP0003959_abnormal_lean_body	0.98417275
67	MP0002127_abnormal_cardiovascular_syste	0.97557236
68	MP0009745_abnormal_behavioral_response	0.97036130
69	MP0001145_abnormal_male_reproductive	0.96165825
70	MP0003635_abnormal_synaptic_transmissio	0.94484603
71	MP0005647_abnormal_sex_gland	0.92879235
72	MP0002067_abnormal_sensory_capabilities	0.92693360
73	MP0002229_neurodegeneration	0.89621095
74	MP0000470_abnormal_stomach_morphology	0.87128925
75	MP0000762_abnormal_tongue_morphology	0.86483488
76	MP0002233_abnormal_nose_morphology	0.86360319
77	MP0008995_early_reproductive_senescence	0.83906148
78	MP0009046_muscle_twitch	0.82633189
79	MP0008961_abnormal_basal_metabolism	0.82423402
80	MP0010094_abnormal_chromosome_stability	0.81511934
81	MP0005645_abnormal_hypothalamus_physiol	0.78956030
82	MP0002095_abnormal_skin_pigmentation	0.78786835
83	MP0004742_abnormal_vestibular_system	0.78775310
84	MP0001324_abnormal_eye_pigmentation	0.78695676
85	MP0001968_abnormal_touch/_nociception	0.77335440
86	MP0003868_abnormal_feces_composition	0.77218777
87	MP0000015_abnormal_ear_pigmentation	0.75942648
88	MP0000579_abnormal_nail_morphology	0.75763759
89	MP0001765_abnormal_ion_homeostasis	0.74673158
90	MP0003077_abnormal_cell_cycle	0.74473717
91	MP0001730_embryonic_growth_arrest	0.72830518
92	MP0002735_abnormal_chemical_nociception	0.72302882
93	MP0003646_muscle_fatigue	0.70699962
94	MP0002752_abnormal_somatic_nervous	0.69433176
95	MP0004859_abnormal_synaptic_plasticity	0.68652703
96	MP0002572_abnormal_emotion/affect_behav	0.68265290
97	MP0003252_abnormal_bile_duct	0.67082892
98	MP0000230_abnormal_systemic_arterial	0.66662636
99	MP0003880_abnormal_central_pattern	0.66132308
100	MP0002557_abnormal_social/conspecific_i	0.65794607

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	6.71859126
2	Congenital sensorineural hearing impairment (HP:0008527)	5.36891541
3	Impulsivity (HP:0100710)	5.29704466
4	Abnormality of abdominal situs (HP:0011620)	5.07388879
5	Abdominal situs inversus (HP:0003363)	5.07388879
6	Male infertility (HP:0003251)	4.53057529
7	Hypophosphatemic rickets (HP:0004912)	4.32946228
8	Premature ovarian failure (HP:0008209)	4.23163046
9	Anterior segment dysgenesis (HP:0007700)	3.80734054
10	Apathy (HP:0000741)	3.64615323
11	Lower limb hyperreflexia (HP:0002395)	3.63439975
12	Gaze-evoked nystagmus (HP:0000640)	3.48557526
13	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.45043596
14	Hypoplasia of the fovea (HP:0007750)	3.45043596
15	Malnutrition (HP:0004395)	3.37942271
16	Septo-optic dysplasia (HP:0100842)	3.36996364
17	Pili torti (HP:0003777)	3.30753955
18	Diminished motivation (HP:0000745)	3.29288384
19	Decreased circulating renin level (HP:0003351)	3.25730464
20	Lip pit (HP:0100267)	3.25458906
21	Urethral obstruction (HP:0000796)	3.01859815
22	Bilateral sensorineural hearing impairment (HP:0008619)	2.98587834
23	Myokymia (HP:0002411)	2.97665033
24	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.92202385
25	Osteomalacia (HP:0002749)	2.87648513
26	Bony spicule pigmentary retinopathy (HP:0007737)	2.86153417
27	Median cleft lip (HP:0000161)	2.85793230
28	Progressive cerebellar ataxia (HP:0002073)	2.83917742
29	Hypokinesia (HP:0002375)	2.76618916
30	Abnormal auditory evoked potentials (HP:0006958)	2.73736047
31	Aplasia of the musculature (HP:0100854)	2.73433972
32	Short tibia (HP:0005736)	2.62297341
33	Spinal muscular atrophy (HP:0007269)	2.61789355
34	Abnormality of the fovea (HP:0000493)	2.54991816
35	Dysdiadochokinesis (HP:0002075)	2.51346949
36	Hyperactive renin-angiotensin system (HP:0000841)	2.41944525
37	Infertility (HP:0000789)	2.41698007
38	Palpebral edema (HP:0100540)	2.41579251
39	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.41474640
40	Supernumerary spleens (HP:0009799)	2.38784727
41	Bundle branch block (HP:0011710)	2.37827131
42	Oligodactyly (hands) (HP:0001180)	2.36206415
43	Optic nerve hypoplasia (HP:0000609)	2.35399171
44	Attenuation of retinal blood vessels (HP:0007843)	2.29038312
45	Muscle stiffness (HP:0003552)	2.27687381
46	Abnormal ciliary motility (HP:0012262)	2.27395530
47	Maternal diabetes (HP:0009800)	2.26298245
48	Truncal obesity (HP:0001956)	2.25606306
49	Striae distensae (HP:0001065)	2.25575569
50	Increased circulating renin level (HP:0000848)	2.23240300
51	Hyperkalemia (HP:0002153)	2.19756720
52	Skin pits (HP:0100276)	2.18521297
53	Facial hemangioma (HP:0000329)	2.17373738
54	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.16896845
55	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.14430220
56	Abnormality of the labia minora (HP:0012880)	2.12746354
57	Ectopic kidney (HP:0000086)	2.10829303
58	Absent septum pellucidum (HP:0001331)	2.10286222
59	Partial duplication of thumb phalanx (HP:0009944)	2.10281432
60	Neurofibrillary tangles (HP:0002185)	2.10072596
61	Pendular nystagmus (HP:0012043)	2.09926008
62	Sensory axonal neuropathy (HP:0003390)	2.08597860
63	Facial cleft (HP:0002006)	2.07848690
64	Dysmetric saccades (HP:0000641)	2.06627569
65	Absent thumb (HP:0009777)	2.05421317
66	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.03444845
67	Aplasia/Hypoplasia of the macula (HP:0008059)	2.03409878
68	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	2.01170638
69	Tubular atrophy (HP:0000092)	2.00177471
70	Periauricular skin pits (HP:0100277)	1.99127729
71	Preauricular pit (HP:0004467)	1.99127729
72	Rhinitis (HP:0012384)	1.98324679
73	Hypercortisolism (HP:0001578)	1.97378974
74	Chromsome breakage (HP:0040012)	1.94434807
75	Abnormality of the renal cortex (HP:0011035)	1.93655632
76	Abnormality of dental color (HP:0011073)	1.91889906
77	Metaphyseal irregularity (HP:0003025)	1.89831383
78	Enlarged epiphyses (HP:0010580)	1.89458588
79	Tubulointerstitial fibrosis (HP:0005576)	1.89292147
80	Abnormal respiratory motile cilium physiology (HP:0012261)	1.87221418
81	Abnormal hair laboratory examination (HP:0003328)	1.87064262
82	Duplication of thumb phalanx (HP:0009942)	1.86235494
83	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.86120218
84	Generalized aminoaciduria (HP:0002909)	1.84614731
85	Oligodactyly (HP:0012165)	1.82407969
86	Abnormal gallbladder physiology (HP:0012438)	1.82239672
87	Cholecystitis (HP:0001082)	1.82239672
88	Retinitis pigmentosa (HP:0000510)	1.81998679
89	Anhidrosis (HP:0000970)	1.80975003
90	Gonadotropin excess (HP:0000837)	1.80931747
91	Adrenal overactivity (HP:0002717)	1.79476223
92	Abnormality of DNA repair (HP:0003254)	1.78680945
93	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.77930033
94	Abnormality of the anterior chamber (HP:0000593)	1.77254116
95	Tubulointerstitial abnormality (HP:0001969)	1.74770217
96	Proximal tubulopathy (HP:0000114)	1.74700960
97	Abnormality of renin-angiotensin system (HP:0000847)	1.73310572
98	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.72707691
99	Atonic seizures (HP:0010819)	1.71698251
100	Delayed epiphyseal ossification (HP:0002663)	1.71646006

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	4.67617018
2	CDK19	3.80433936
3	ARAF	3.69401377
4	MAP3K13	3.61660632
5	WNK4	3.27174618
6	TAOK3	2.79449115
7	NEK6	2.76552041
8	CDK12	2.48669981
9	TNIK	2.41413978
10	INSRR	2.29769948
11	NME1	2.23981747
12	MET	2.21899052
13	STK24	2.19666664
14	WNK1	2.14221584
15	MST1R	1.95811019
16	NEK2	1.93224909
17	MELK	1.89237099
18	AURKA	1.85001179
19	TRIM28	1.82862386
20	BMPR1B	1.63507525
21	NTRK2	1.62733133
22	STK39	1.43825545
23	FRK	1.42962195
24	ZAK	1.40472877
25	TESK2	1.37459950
26	BRAF	1.37363871
27	CDK7	1.29134267
28	TTK	1.27598367
29	MOS	1.27433741
30	STK16	1.18698108
31	MAP3K4	1.15322123
32	PRKCI	1.10715020
33	PKN1	1.07449756
34	STK3	1.07293703
35	TXK	1.05059240
36	SRPK1	1.01867823
37	TNK2	1.00187944
38	NLK	1.00140008
39	MAPK13	0.99882073
40	CDK8	0.98665532
41	VRK1	0.92566511
42	PLK1	0.91897772
43	LATS1	0.88817933
44	MAP4K2	0.88301140
45	NTRK3	0.87199180
46	MAP3K6	0.85257054
47	CDC7	0.84162395
48	RAF1	0.83014569
49	MARK2	0.82655553
50	ACVR1B	0.82416588
51	TLK1	0.80037040
52	CHEK2	0.73957181
53	EPHA4	0.71828235
54	OXSR1	0.71097618
55	STK38L	0.67238261
56	CSNK1D	0.66105347
57	EIF2AK3	0.60776078
58	MAPKAPK3	0.59409861
59	MTOR	0.59255114
60	KSR2	0.58215296
61	MAP3K5	0.57757289
62	MARK3	0.57286506
63	CHEK1	0.57224508
64	MAP3K7	0.56598743
65	MUSK	0.55146942
66	TGFBR1	0.55068857
67	TIE1	0.53625288
68	CAMK1	0.51672154
69	RET	0.50628161
70	EEF2K	0.50462145
71	PDK1	0.50177387
72	CSNK1G1	0.50055167
73	ADRBK2	0.49945972
74	CDK2	0.49700072
75	CDK5	0.48485707
76	PIM1	0.46958079
77	PRKCZ	0.45346114
78	BUB1	0.44753719
79	PLK4	0.44748416
80	NUAK1	0.44479903
81	PRKG1	0.42939485
82	MAPK11	0.41997327
83	CSNK1E	0.41516466
84	LATS2	0.39402028
85	AURKB	0.39250167
86	CAMK4	0.38858760
87	PAK1	0.38488671
88	ICK	0.38266029
89	BRSK1	0.36498099
90	CAMK2A	0.35825402
91	PRKAA1	0.35201569
92	CDK1	0.35186746
93	PRKACA	0.32620879
94	PTK2B	0.30958992
95	ATM	0.29538360
96	PTK2	0.29260580
97	ATR	0.28769963
98	MAP2K7	0.28314211
99	GSK3B	0.28197469
100	CDK11A	0.27604871

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	4.38317609
2	Basal transcription factors_Homo sapiens_hsa03022	3.91932811
3	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	3.42848497
4	Ovarian steroidogenesis_Homo sapiens_hsa04913	3.40217697
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.29590113
6	Oocyte meiosis_Homo sapiens_hsa04114	2.93586930
7	Olfactory transduction_Homo sapiens_hsa04740	2.81889216
8	Taste transduction_Homo sapiens_hsa04742	2.56431892
9	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.53970945
10	Nicotine addiction_Homo sapiens_hsa05033	2.30769550
11	Phototransduction_Homo sapiens_hsa04744	2.21262022
12	ABC transporters_Homo sapiens_hsa02010	2.00260115
13	Morphine addiction_Homo sapiens_hsa05032	1.97030319
14	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.83632577
15	GABAergic synapse_Homo sapiens_hsa04727	1.79640896
16	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.77488431
17	Cell cycle_Homo sapiens_hsa04110	1.62496728
18	Bile secretion_Homo sapiens_hsa04976	1.58261964
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.54634950
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.49519220
21	Insulin secretion_Homo sapiens_hsa04911	1.44846716
22	Salivary secretion_Homo sapiens_hsa04970	1.40808206
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.36679136
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.36621545
25	Circadian entrainment_Homo sapiens_hsa04713	1.34106200
26	RNA polymerase_Homo sapiens_hsa03020	1.33795108
27	Serotonergic synapse_Homo sapiens_hsa04726	1.32885979
28	Mismatch repair_Homo sapiens_hsa03430	1.26712727
29	Base excision repair_Homo sapiens_hsa03410	1.25790798
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.21335184
31	RNA degradation_Homo sapiens_hsa03018	1.19268260
32	Caffeine metabolism_Homo sapiens_hsa00232	1.19091500
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.17838926
34	Calcium signaling pathway_Homo sapiens_hsa04020	1.17207669
35	Gap junction_Homo sapiens_hsa04540	1.16468056
36	Circadian rhythm_Homo sapiens_hsa04710	1.14421445
37	Homologous recombination_Homo sapiens_hsa03440	1.10635135
38	Cholinergic synapse_Homo sapiens_hsa04725	1.07599710
39	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.06578965
40	Pancreatic secretion_Homo sapiens_hsa04972	1.03930141
41	Protein digestion and absorption_Homo sapiens_hsa04974	0.97359262
42	Purine metabolism_Homo sapiens_hsa00230	0.97146284
43	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.94125831
44	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.93255216
45	Glutamatergic synapse_Homo sapiens_hsa04724	0.91283396
46	mRNA surveillance pathway_Homo sapiens_hsa03015	0.87065586
47	cAMP signaling pathway_Homo sapiens_hsa04024	0.84272893
48	Ether lipid metabolism_Homo sapiens_hsa00565	0.78264777
49	RNA transport_Homo sapiens_hsa03013	0.76952144
50	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.76778520
51	Arginine and proline metabolism_Homo sapiens_hsa00330	0.76527761
52	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.76167642
53	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.74648742
54	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.73174515
55	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.73129614
56	Long-term depression_Homo sapiens_hsa04730	0.72386089
57	Gastric acid secretion_Homo sapiens_hsa04971	0.70226236
58	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.69490225
59	Histidine metabolism_Homo sapiens_hsa00340	0.66779979
60	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.65477249
61	p53 signaling pathway_Homo sapiens_hsa04115	0.64575592
62	Cocaine addiction_Homo sapiens_hsa05030	0.63415566
63	Retinol metabolism_Homo sapiens_hsa00830	0.63052122
64	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.62350608
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61482946
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.61344880
67	Dopaminergic synapse_Homo sapiens_hsa04728	0.60625843
68	Butanoate metabolism_Homo sapiens_hsa00650	0.59785151
69	Tryptophan metabolism_Homo sapiens_hsa00380	0.58762626
70	Arginine biosynthesis_Homo sapiens_hsa00220	0.58395037
71	Amphetamine addiction_Homo sapiens_hsa05031	0.55194724
72	Lysine degradation_Homo sapiens_hsa00310	0.49317639
73	Nucleotide excision repair_Homo sapiens_hsa03420	0.42862771
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42283246
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.40595501
76	Ras signaling pathway_Homo sapiens_hsa04014	0.38300779
77	MAPK signaling pathway_Homo sapiens_hsa04010	0.37731225
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.35071238
79	GnRH signaling pathway_Homo sapiens_hsa04912	0.34702994
80	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.32746334
81	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.32607613
82	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.31960841
83	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.31899452
84	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.28306553
85	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.28129094
86	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.27490869
87	Hippo signaling pathway_Homo sapiens_hsa04390	0.27088779
88	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.26615939
89	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.25756795
90	Vibrio cholerae infection_Homo sapiens_hsa05110	0.25049012
91	Rap1 signaling pathway_Homo sapiens_hsa04015	0.24696780
92	Adherens junction_Homo sapiens_hsa04520	0.24615417
93	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.24190984
94	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.23084627
95	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.22690418
96	Amoebiasis_Homo sapiens_hsa05146	0.22680430
97	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.21825374
98	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.21782974
99	Tight junction_Homo sapiens_hsa04530	0.21207941
100	Pyrimidine metabolism_Homo sapiens_hsa00240	0.21062263

FAM90A24P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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