ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	8.02100767
2	histone H3-K9 demethylation (GO:0033169)	7.33659025
3	regulation of retinoic acid receptor signaling pathway (GO:0048385)	6.55983440
4	positive regulation of amino acid transport (GO:0051957)	6.42964143
5	postsynaptic membrane organization (GO:0001941)	6.20528404
6	NIK/NF-kappaB signaling (GO:0038061)	6.08431683
7	response to pheromone (GO:0019236)	5.80858168
8	regulation of neuron projection regeneration (GO:0070570)	5.67774593
9	regulation of axon regeneration (GO:0048679)	5.67774593
10	regulation of transmission of nerve impulse (GO:0051969)	5.51516464
11	centriole replication (GO:0007099)	5.36630263
12	synaptonemal complex assembly (GO:0007130)	5.36175366
13	imidazole-containing compound metabolic process (GO:0052803)	5.25276489
14	tongue development (GO:0043586)	4.99024149
15	synaptonemal complex organization (GO:0070193)	4.89527503
16	DNA methylation involved in gamete generation (GO:0043046)	4.60376298
17	piRNA metabolic process (GO:0034587)	4.55326276
18	positive regulation of action potential (GO:0045760)	4.53973682
19	aggressive behavior (GO:0002118)	4.53479452
20	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.45778208
21	positive regulation of neurological system process (GO:0031646)	4.41633716
22	neuron cell-cell adhesion (GO:0007158)	4.37836267
23	locomotory exploration behavior (GO:0035641)	4.27652305
24	gamma-aminobutyric acid signaling pathway (GO:0007214)	4.26115243
25	chromosome organization involved in meiosis (GO:0070192)	4.18494422
26	positive regulation of meiosis (GO:0045836)	4.15882750
27	positive regulation of gastrulation (GO:2000543)	4.08343306
28	positive regulation of digestive system process (GO:0060456)	4.01272124
29	regulation of receptor binding (GO:1900120)	3.95541172
30	poly(A)+ mRNA export from nucleus (GO:0016973)	3.94085378
31	male meiosis (GO:0007140)	3.93779335
32	negative regulation of amino acid transport (GO:0051956)	3.92482513
33	positive regulation of meiotic cell cycle (GO:0051446)	3.91869598
34	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.85257738
35	male meiosis I (GO:0007141)	3.83666434
36	dendritic spine morphogenesis (GO:0060997)	3.81831988
37	centriole assembly (GO:0098534)	3.79652014
38	regulation of acrosome reaction (GO:0060046)	3.70645437
39	regulation of glutamate secretion (GO:0014048)	3.68983698
40	positive regulation of amine transport (GO:0051954)	3.67795213
41	oocyte development (GO:0048599)	3.67383224
42	gonadal mesoderm development (GO:0007506)	3.66358072
43	regulation of female receptivity (GO:0045924)	3.61702203
44	positive regulation of organic acid transport (GO:0032892)	3.61336937
45	drinking behavior (GO:0042756)	3.57783152
46	regulation of uterine smooth muscle contraction (GO:0070472)	3.55520805
47	behavioral response to nicotine (GO:0035095)	3.53110630
48	presynaptic membrane assembly (GO:0097105)	3.52377427
49	embryonic skeletal joint morphogenesis (GO:0060272)	3.52059024
50	resolution of meiotic recombination intermediates (GO:0000712)	3.50338595
51	meiosis I (GO:0007127)	3.49458685
52	response to inactivity (GO:0014854)	3.45096593
53	regulation of female gonad development (GO:2000194)	3.44249105
54	regulation of action potential (GO:0098900)	3.41675667
55	neurotransmitter-gated ion channel clustering (GO:0072578)	3.41009508
56	negative regulation of granulocyte differentiation (GO:0030853)	3.39190924
57	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.38193237
58	protein kinase C signaling (GO:0070528)	3.31688942
59	protein neddylation (GO:0045116)	3.26887554
60	positive regulation of synaptic transmission, GABAergic (GO:0032230)	3.24798641
61	urinary tract smooth muscle contraction (GO:0014848)	3.22308375
62	vocalization behavior (GO:0071625)	3.20936147
63	positive regulation of synaptic transmission, glutamatergic (GO:0051968)	3.11565412
64	spinal cord development (GO:0021510)	3.11481486
65	regulation of collateral sprouting (GO:0048670)	3.10685492
66	multicellular organism reproduction (GO:0032504)	3.01834460
67	response to auditory stimulus (GO:0010996)	3.00428837
68	presynaptic membrane organization (GO:0097090)	2.99238514
69	meiotic nuclear division (GO:0007126)	2.97765256
70	exploration behavior (GO:0035640)	2.91798225
71	tachykinin receptor signaling pathway (GO:0007217)	2.90269012
72	motile cilium assembly (GO:0044458)	2.90001114
73	negative regulation of axon extension (GO:0030517)	2.89238795
74	single fertilization (GO:0007338)	2.87370787
75	female mating behavior (GO:0060180)	2.83432165
76	protein localization to synapse (GO:0035418)	2.83202806
77	fertilization (GO:0009566)	2.80994786
78	adult walking behavior (GO:0007628)	2.79207093
79	positive regulation of catecholamine secretion (GO:0033605)	2.76086940
80	auditory behavior (GO:0031223)	2.74877176
81	L-fucose catabolic process (GO:0042355)	2.72472026
82	fucose catabolic process (GO:0019317)	2.72472026
83	L-fucose metabolic process (GO:0042354)	2.72472026
84	type B pancreatic cell development (GO:0003323)	2.72357215
85	inositol metabolic process (GO:0006020)	2.71554730
86	retinal ganglion cell axon guidance (GO:0031290)	2.69799277
87	regulation of amino acid transport (GO:0051955)	2.68396336
88	motor neuron axon guidance (GO:0008045)	2.64275169
89	meiotic cell cycle (GO:0051321)	2.63771260
90	regulation of G0 to G1 transition (GO:0070316)	2.63452369
91	regulation of cytokine production involved in inflammatory response (GO:1900015)	2.62951726
92	negative regulation of reproductive process (GO:2000242)	2.62456390
93	organ induction (GO:0001759)	2.60611799
94	meiotic cell cycle process (GO:1903046)	2.59100294
95	regulation of meiosis I (GO:0060631)	2.58703595
96	neurogenesis (GO:0022008)	2.58395562
97	protein targeting to Golgi (GO:0000042)	2.57856975
98	protein localization to Golgi apparatus (GO:0034067)	2.55779911
99	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.55104652
100	oogenesis (GO:0048477)	2.54846595

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	7.18777386
2	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.73127868
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.44306719
4	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.37697127
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.34941997
6	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.30920959
7	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.24263700
8	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.15795528
9	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.14583401
10	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.11558370
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.10670811
12	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.05236117
13	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.03087863
14	EZH2_22144423_ChIP-Seq_EOC_Human	10.7143562
15	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.97473016
16	RNF2_27304074_Chip-Seq_NSC_Mouse	1.97450160
17	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.95477932
18	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.95477932
19	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.91145873
20	DROSHA_22980978_ChIP-Seq_HELA_Human	1.88422566
21	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.84643934
22	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.78385154
23	VDR_22108803_ChIP-Seq_LS180_Human	1.76144491
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.75854915
25	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.75289839
26	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.72596817
27	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.67606093
28	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.66614873
29	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.65923209
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.64097842
31	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.61682445
32	REST_21632747_ChIP-Seq_MESCs_Mouse	1.61322457
33	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.58363668
34	ZNF274_21170338_ChIP-Seq_K562_Hela	1.58316451
35	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.56947637
36	TCF4_23295773_ChIP-Seq_U87_Human	1.51870941
37	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.47277206
38	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.47014019
39	RUNX2_22187159_ChIP-Seq_PCA_Human	1.41205398
40	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.38264344
41	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.38027448
42	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.37173346
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.36538879
44	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.36391641
45	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.31102532
46	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.29733208
47	FUS_26573619_Chip-Seq_HEK293_Human	1.26382767
48	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.23806403
49	BCAT_22108803_ChIP-Seq_LS180_Human	1.23378594
50	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.20878675
51	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.20549604
52	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.20496353
53	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.19974724
54	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.19123458
55	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.18218781
56	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.16953332
57	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.16885428
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.15916105
59	CBP_20019798_ChIP-Seq_JUKART_Human	1.15916105
60	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.13051333
61	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.12871331
62	STAT3_23295773_ChIP-Seq_U87_Human	1.12616546
63	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.10102472
64	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.07360976
65	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.05661399
66	AR_25329375_ChIP-Seq_VCAP_Human	1.04517921
67	TAF2_19829295_ChIP-Seq_ESCs_Human	1.04118931
68	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.04063252
69	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.00886666
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.00507800
71	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.00403868
72	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.00013342
73	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.99418907
74	P300_19829295_ChIP-Seq_ESCs_Human	0.98511021
75	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.97593585
76	RXR_22108803_ChIP-Seq_LS180_Human	0.95324815
77	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95087461
78	AR_19668381_ChIP-Seq_PC3_Human	0.94792059
79	JUN_21703547_ChIP-Seq_K562_Human	0.94726566
80	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.92980126
81	TP63_22573176_ChIP-Seq_HFKS_Human	0.91757907
82	IRF1_19129219_ChIP-ChIP_H3396_Human	0.90994907
83	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.88594443
84	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.87159519
85	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.85172757
86	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.84868429
87	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.83904276
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.83765152
89	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.82672520
90	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.82652630
91	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.82054876
92	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.82054876
93	SOX2_19829295_ChIP-Seq_ESCs_Human	0.81829695
94	NANOG_19829295_ChIP-Seq_ESCs_Human	0.81829695
95	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.81461326
96	NCOR_22424771_ChIP-Seq_293T_Human	0.81447441
97	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.80670033
98	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.80412853
99	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.80213535
100	CTCF_27219007_Chip-Seq_Bcells_Human	0.80156468

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.97043676
2	MP0002736_abnormal_nociception_after	4.12963212
3	MP0003136_yellow_coat_color	3.74155467
4	MP0003283_abnormal_digestive_organ	3.69282521
5	MP0000631_abnormal_neuroendocrine_gland	3.56647808
6	MP0001968_abnormal_touch/_nociception	3.41213683
7	MP0010030_abnormal_orbit_morphology	3.22821303
8	MP0009384_cardiac_valve_regurgitation	2.93867609
9	MP0004782_abnormal_surfactant_physiolog	2.70566995
10	MP0001986_abnormal_taste_sensitivity	2.49594893
11	MP0009379_abnormal_foot_pigmentation	2.47602580
12	MP0002735_abnormal_chemical_nociception	2.38945485
13	MP0005423_abnormal_somatic_nervous	2.32200533
14	MP0000372_irregular_coat_pigmentation	2.18673114
15	MP0002234_abnormal_pharynx_morphology	2.06059632
16	MP0002160_abnormal_reproductive_system	2.02122003
17	MP0005646_abnormal_pituitary_gland	2.00948453
18	MP0001502_abnormal_circadian_rhythm	1.85983126
19	MP0002210_abnormal_sex_determination	1.69403838
20	MP0000778_abnormal_nervous_system	1.62786853
21	MP0002272_abnormal_nervous_system	1.62555613
22	MP0004859_abnormal_synaptic_plasticity	1.54867443
23	MP0000049_abnormal_middle_ear	1.51972138
24	MP0004133_heterotaxia	1.48926796
25	MP0001929_abnormal_gametogenesis	1.46746903
26	MP0003950_abnormal_plasma_membrane	1.46241872
27	MP0003183_abnormal_peptide_metabolism	1.46115961
28	MP0000566_synostosis	1.43069554
29	MP0000013_abnormal_adipose_tissue	1.42347359
30	MP0001485_abnormal_pinna_reflex	1.28353534
31	MP0006276_abnormal_autonomic_nervous	1.25942214
32	MP0003699_abnormal_female_reproductive	1.25062310
33	MP0005499_abnormal_olfactory_system	1.21532625
34	MP0005394_taste/olfaction_phenotype	1.21532625
35	MP0000678_abnormal_parathyroid_gland	1.21404015
36	MP0002734_abnormal_mechanical_nocicepti	1.20251514
37	MP0002277_abnormal_respiratory_mucosa	1.19182051
38	MP0004142_abnormal_muscle_tone	1.17906337
39	MP0000653_abnormal_sex_gland	1.17819133
40	MP0002233_abnormal_nose_morphology	1.17715263
41	MP0005551_abnormal_eye_electrophysiolog	1.16954251
42	MP0000751_myopathy	1.15421480
43	MP0002249_abnormal_larynx_morphology	1.14544280
44	MP0001661_extended_life_span	1.11620403
45	MP0001293_anophthalmia	1.10341781
46	MP0002067_abnormal_sensory_capabilities	1.09735578
47	MP0010307_abnormal_tumor_latency	1.08946025
48	MP0004270_analgesia	1.08425568
49	MP0005187_abnormal_penis_morphology	1.08068956
50	MP0003866_abnormal_defecation	1.07393636
51	MP0001486_abnormal_startle_reflex	1.06103365
52	MP0008995_early_reproductive_senescence	1.05600878
53	MP0002557_abnormal_social/conspecific_i	1.05574521
54	MP0003698_abnormal_male_reproductive	1.04412495
55	MP0010368_abnormal_lymphatic_system	1.04125298
56	MP0000428_abnormal_craniofacial_morphol	1.03495354
57	MP0008877_abnormal_DNA_methylation	1.03183816
58	MP0005257_abnormal_intraocular_pressure	1.02394826
59	MP0001324_abnormal_eye_pigmentation	1.02244878
60	MP0003115_abnormal_respiratory_system	1.02186454
61	MP0008789_abnormal_olfactory_epithelium	1.01306721
62	MP0001145_abnormal_male_reproductive	1.00893740
63	MP0005389_reproductive_system_phenotype	1.00071969
64	MP0005410_abnormal_fertilization	0.98548055
65	MP0001664_abnormal_digestion	0.97920796
66	MP0000026_abnormal_inner_ear	0.95330601
67	MP0002161_abnormal_fertility/fecundity	0.92782599
68	MP0003635_abnormal_synaptic_transmissio	0.92740387
69	MP0002116_abnormal_craniofacial_bone	0.90444195
70	MP0002752_abnormal_somatic_nervous	0.87208400
71	MP0001963_abnormal_hearing_physiology	0.86702685
72	MP0001119_abnormal_female_reproductive	0.86351624
73	MP0001666_abnormal_nutrient_absorption	0.85374974
74	MP0002184_abnormal_innervation	0.83830365
75	MP0002063_abnormal_learning/memory/cond	0.83084673
76	MP0000003_abnormal_adipose_tissue	0.82688679
77	MP0003690_abnormal_glial_cell	0.81965094
78	MP0003755_abnormal_palate_morphology	0.81835933
79	MP0000579_abnormal_nail_morphology	0.81425784
80	MP0002152_abnormal_brain_morphology	0.81274942
81	MP0002751_abnormal_autonomic_nervous	0.79320517
82	MP0000955_abnormal_spinal_cord	0.78506241
83	MP0002882_abnormal_neuron_morphology	0.78066242
84	MP0003119_abnormal_digestive_system	0.77899463
85	MP0000920_abnormal_myelination	0.76846230
86	MP0003880_abnormal_central_pattern	0.76625040
87	MP0003890_abnormal_embryonic-extraembry	0.75967578
88	MP0002229_neurodegeneration	0.75713060
89	MP0001286_abnormal_eye_development	0.74193527
90	MP0001764_abnormal_homeostasis	0.72813139
91	MP0002572_abnormal_emotion/affect_behav	0.72393476
92	MP0003938_abnormal_ear_development	0.71555850
93	MP0003861_abnormal_nervous_system	0.71107308
94	MP0001529_abnormal_vocalization	0.71007271
95	MP0005391_vision/eye_phenotype	0.69924819
96	MP0000762_abnormal_tongue_morphology	0.69642613
97	MP0004145_abnormal_muscle_electrophysio	0.69344175
98	MP0004811_abnormal_neuron_physiology	0.67776837
99	MP0004885_abnormal_endolymph	0.66364429
100	MP0000462_abnormal_digestive_system	0.65440409

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Septo-optic dysplasia (HP:0100842)	9.36509954
2	Optic nerve hypoplasia (HP:0000609)	5.53872727
3	Absent septum pellucidum (HP:0001331)	4.84611188
4	Abnormality of the septum pellucidum (HP:0007375)	4.83017187
5	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	4.60534323
6	Abnormality of the sella turcica (HP:0002679)	4.25318430
7	Pancreatic fibrosis (HP:0100732)	3.82235834
8	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	3.46493037
9	Abnormality of the pons (HP:0007361)	3.42942961
10	Hypoplasia of the pons (HP:0012110)	3.38139413
11	Asplenia (HP:0001746)	3.24623117
12	Enlarged epiphyses (HP:0010580)	3.13413451
13	Aplasia/Hypoplasia of the spleen (HP:0010451)	3.07128968
14	Broad face (HP:0000283)	3.05656366
15	True hermaphroditism (HP:0010459)	2.97750172
16	Annular pancreas (HP:0001734)	2.87713427
17	Abnormality of cells of the erythroid lineage (HP:0012130)	2.79755204
18	Cystic liver disease (HP:0006706)	2.77122144
19	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.67350841
20	Abdominal situs inversus (HP:0003363)	2.66471299
21	Abnormality of abdominal situs (HP:0011620)	2.66471299
22	Hyperlipoproteinemia (HP:0010980)	2.64997379
23	Abnormal biliary tract physiology (HP:0012439)	2.63356124
24	Bile duct proliferation (HP:0001408)	2.63356124
25	Abnormal number of erythroid precursors (HP:0012131)	2.58117916
26	Spinal canal stenosis (HP:0003416)	2.55966874
27	Biconcave vertebral bodies (HP:0004586)	2.54839117
28	Medial flaring of the eyebrow (HP:0010747)	2.53712407
29	Abnormality of the femoral head (HP:0003368)	2.52126913
30	Supernumerary spleens (HP:0009799)	2.51896382
31	Cervical subluxation (HP:0003308)	2.45632225
32	Genital tract atresia (HP:0001827)	2.39489417
33	Wrist flexion contracture (HP:0001239)	2.36936464
34	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.36649104
35	Joint stiffness (HP:0001387)	2.36239235
36	Oligodactyly (hands) (HP:0001180)	2.34684318
37	Absent epiphyses (HP:0010577)	2.31999709
38	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.31999709
39	Pancreatic cysts (HP:0001737)	2.26941435
40	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.24166943
41	Congenital sensorineural hearing impairment (HP:0008527)	2.23861191
42	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.23706815
43	Congenital primary aphakia (HP:0007707)	2.19939605
44	Pendular nystagmus (HP:0012043)	2.19331919
45	Postaxial foot polydactyly (HP:0001830)	2.18691453
46	Adrenal hypoplasia (HP:0000835)	2.18259062
47	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	2.18239949
48	Abnormality of femoral epiphyses (HP:0006499)	2.18239949
49	Gait imbalance (HP:0002141)	2.16016328
50	Short tibia (HP:0005736)	2.14820532
51	Occipital encephalocele (HP:0002085)	2.12880621
52	Palpebral edema (HP:0100540)	2.11819162
53	Flat capital femoral epiphysis (HP:0003370)	2.06178019
54	Sandal gap (HP:0001852)	2.05707509
55	Abnormality of the vertebral endplates (HP:0005106)	2.05266435
56	Impulsivity (HP:0100710)	2.05024710
57	Vaginal atresia (HP:0000148)	2.02053174
58	Abnormality of the fetal cardiovascular system (HP:0010948)	2.01866642
59	Abnormal umbilical cord blood vessels (HP:0011403)	2.01866642
60	Single umbilical artery (HP:0001195)	2.01866642
61	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.01399245
62	Growth hormone deficiency (HP:0000824)	1.98037264
63	Short chin (HP:0000331)	1.96837071
64	Aortic regurgitation (HP:0001659)	1.96464876
65	Hypoplasia of the iris (HP:0007676)	1.95914719
66	Poor coordination (HP:0002370)	1.95619694
67	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.95202051
68	Aortic valve stenosis (HP:0001650)	1.92066533
69	Cerebellar dysplasia (HP:0007033)	1.90083954
70	Midline defect of the nose (HP:0004122)	1.89884526
71	Nephronophthisis (HP:0000090)	1.88538631
72	Abnormal ciliary motility (HP:0012262)	1.88159500
73	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.87993034
74	Abnormality of chromosome segregation (HP:0002916)	1.87739791
75	Abnormal respiratory motile cilium physiology (HP:0012261)	1.87281301
76	Amblyopia (HP:0000646)	1.86287095
77	Lower limb asymmetry (HP:0100559)	1.85061163
78	Epidermoid cyst (HP:0200040)	1.85015423
79	Myokymia (HP:0002411)	1.84000411
80	Broad-based gait (HP:0002136)	1.82230874
81	Abnormality of midbrain morphology (HP:0002418)	1.81979883
82	Molar tooth sign on MRI (HP:0002419)	1.81979883
83	Abnormality of DNA repair (HP:0003254)	1.79909554
84	Tracheal stenosis (HP:0002777)	1.79290516
85	Hyperventilation (HP:0002883)	1.79068019
86	Nephrogenic diabetes insipidus (HP:0009806)	1.75704261
87	Delayed epiphyseal ossification (HP:0002663)	1.73090879
88	Premature ovarian failure (HP:0008209)	1.72069912
89	Primary amenorrhea (HP:0000786)	1.71169655
90	Maternal diabetes (HP:0009800)	1.69849507
91	Oligodactyly (HP:0012165)	1.69095195
92	Obstructive sleep apnea (HP:0002870)	1.68502787
93	J-shaped sella turcica (HP:0002680)	1.67592314
94	Abnormality of the renal collecting system (HP:0004742)	1.67525143
95	Nuclear cataract (HP:0100018)	1.67432110
96	Mitral regurgitation (HP:0001653)	1.67133459
97	Submucous cleft hard palate (HP:0000176)	1.66577703
98	Ulnar claw (HP:0001178)	1.65965641
99	Sclerocornea (HP:0000647)	1.65780601
100	Esophageal atresia (HP:0002032)	1.65237566

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	6.18632138
2	TNIK	5.36116295
3	KDR	3.34907631
4	EPHA4	2.84185888
5	WNK4	2.72703161
6	ERBB4	2.59729808
7	MARK1	2.30144868
8	MAP3K11	2.28020787
9	NEK2	2.22834775
10	PINK1	2.22082001
11	CDK12	1.98798278
12	WNK1	1.94959231
13	PRKD2	1.77564961
14	YES1	1.69358155
15	STK39	1.67093305
16	MST1R	1.66804762
17	UHMK1	1.66738048
18	MAP3K5	1.62905010
19	TIE1	1.48169638
20	MKNK2	1.42284596
21	DAPK2	1.41441299
22	MELK	1.40537117
23	NME1	1.39789620
24	AURKA	1.36224638
25	VRK2	1.31286367
26	MET	1.26642933
27	BLK	1.24732674
28	NUAK1	1.12837634
29	MKNK1	1.11407658
30	PBK	1.11387615
31	CAMK1G	1.11008578
32	STK38	1.09935724
33	NLK	1.04788971
34	ZAK	1.03827687
35	VRK1	1.01775405
36	PLK4	1.01193095
37	PRKCH	0.92394526
38	MAP3K12	0.91276090
39	MAPK15	0.86971835
40	DYRK1B	0.86377142
41	CAMK4	0.85276710
42	RET	0.82596528
43	TTK	0.82555850
44	TRPM7	0.82075420
45	DAPK1	0.78907011
46	CDK19	0.78571185
47	PNCK	0.78079838
48	FES	0.75034189
49	AKT3	0.70589928
50	DYRK3	0.70138860
51	STK16	0.69212103
52	PKN1	0.68477594
53	MAPK13	0.68344400
54	GSK3A	0.67478639
55	SGK1	0.66428181
56	TNK2	0.62762398
57	ERBB2	0.62177772
58	MARK2	0.56223000
59	STK38L	0.55823423
60	CSF1R	0.54760139
61	CAMK1D	0.54559306
62	RPS6KB1	0.53607849
63	EPHB2	0.53322322
64	CAMK1	0.49593757
65	LATS2	0.49412083
66	NEK6	0.47378041
67	SGK2	0.46804075
68	PDGFRB	0.45915072
69	PDK1	0.45712931
70	BRAF	0.45364145
71	ATR	0.45206453
72	MAP3K7	0.45105910
73	STK4	0.44543046
74	CDK2	0.44392154
75	GSK3B	0.42911163
76	AURKB	0.41918615
77	PRKD3	0.41842891
78	IGF1R	0.40825753
79	MTOR	0.40697914
80	LATS1	0.40091232
81	TTN	0.39126960
82	AKT2	0.38066432
83	CHEK2	0.37749701
84	CDK5	0.36676739
85	ATM	0.36463949
86	PLK1	0.34012522
87	INSRR	0.33558413
88	CHEK1	0.32699357
89	RPS6KA3	0.31944140
90	MAP2K4	0.31188367
91	STK24	0.31135314
92	TAOK3	0.30986289
93	RPS6KL1	0.30887145
94	RPS6KC1	0.30887145
95	CDK1	0.29984665
96	PLK2	0.29826236
97	DMPK	0.29238463
98	RPS6KA6	0.29114113
99	PDPK1	0.26219957
100	CDC7	0.25736117

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.00864328
2	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.76684032
3	Phototransduction_Homo sapiens_hsa04744	2.60389605
4	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.55142690
5	ECM-receptor interaction_Homo sapiens_hsa04512	2.39978214
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.24199285
7	Ribosome_Homo sapiens_hsa03010	2.18196009
8	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.14708819
9	Basal transcription factors_Homo sapiens_hsa03022	2.13264642
10	Olfactory transduction_Homo sapiens_hsa04740	2.03142399
11	Fanconi anemia pathway_Homo sapiens_hsa03460	1.92838994
12	GABAergic synapse_Homo sapiens_hsa04727	1.86154602
13	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.77973510
14	Basal cell carcinoma_Homo sapiens_hsa05217	1.74465976
15	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.73896350
16	Oocyte meiosis_Homo sapiens_hsa04114	1.66216970
17	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.64873053
18	ABC transporters_Homo sapiens_hsa02010	1.59825667
19	Protein digestion and absorption_Homo sapiens_hsa04974	1.57869539
20	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.57273927
21	Glutamatergic synapse_Homo sapiens_hsa04724	1.56174269
22	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.55423263
23	Taste transduction_Homo sapiens_hsa04742	1.51964641
24	Morphine addiction_Homo sapiens_hsa05032	1.47980955
25	Salivary secretion_Homo sapiens_hsa04970	1.44516410
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.42529743
27	Regulation of autophagy_Homo sapiens_hsa04140	1.40228118
28	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.35333345
29	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.29914720
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.29442739
31	Circadian entrainment_Homo sapiens_hsa04713	1.26325672
32	Calcium signaling pathway_Homo sapiens_hsa04020	1.25843161
33	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.25668143
34	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.20617126
35	Insulin secretion_Homo sapiens_hsa04911	1.17073446
36	Glycerolipid metabolism_Homo sapiens_hsa00561	1.15103261
37	Lysine degradation_Homo sapiens_hsa00310	1.11210316
38	Axon guidance_Homo sapiens_hsa04360	1.10807907
39	Focal adhesion_Homo sapiens_hsa04510	1.09424407
40	RNA transport_Homo sapiens_hsa03013	1.09183474
41	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.04526752
42	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.98707629
43	Huntingtons disease_Homo sapiens_hsa05016	0.98222107
44	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.97909437
45	Amphetamine addiction_Homo sapiens_hsa05031	0.96964894
46	Hippo signaling pathway_Homo sapiens_hsa04390	0.92462131
47	Homologous recombination_Homo sapiens_hsa03440	0.89399896
48	cAMP signaling pathway_Homo sapiens_hsa04024	0.87236766
49	MicroRNAs in cancer_Homo sapiens_hsa05206	0.85653443
50	Cholinergic synapse_Homo sapiens_hsa04725	0.84229587
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.82770975
52	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.81905493
53	Choline metabolism in cancer_Homo sapiens_hsa05231	0.81113475
54	Tight junction_Homo sapiens_hsa04530	0.78418330
55	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.76855856
56	Cardiac muscle contraction_Homo sapiens_hsa04260	0.76800714
57	Wnt signaling pathway_Homo sapiens_hsa04310	0.76090322
58	Cocaine addiction_Homo sapiens_hsa05030	0.74926845
59	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.70176562
60	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.66136981
61	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.65475793
62	Amoebiasis_Homo sapiens_hsa05146	0.64881383
63	Gap junction_Homo sapiens_hsa04540	0.64536269
64	ErbB signaling pathway_Homo sapiens_hsa04012	0.63196009
65	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.61728345
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.61170906
67	Melanogenesis_Homo sapiens_hsa04916	0.60851494
68	RNA degradation_Homo sapiens_hsa03018	0.60344660
69	Small cell lung cancer_Homo sapiens_hsa05222	0.59365458
70	Ether lipid metabolism_Homo sapiens_hsa00565	0.59125843
71	Retinol metabolism_Homo sapiens_hsa00830	0.58942696
72	Linoleic acid metabolism_Homo sapiens_hsa00591	0.58852115
73	Serotonergic synapse_Homo sapiens_hsa04726	0.56779715
74	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.52533852
75	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.52333648
76	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.52093771
77	Long-term potentiation_Homo sapiens_hsa04720	0.52058093
78	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.50769666
79	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.48092022
80	Adherens junction_Homo sapiens_hsa04520	0.47633861
81	Primary immunodeficiency_Homo sapiens_hsa05340	0.47375826
82	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.46663542
83	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.46526171
84	Bile secretion_Homo sapiens_hsa04976	0.45787959
85	mRNA surveillance pathway_Homo sapiens_hsa03015	0.45698241
86	Renin secretion_Homo sapiens_hsa04924	0.45653691
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.44766614
88	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.43646308
89	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.43071838
90	Colorectal cancer_Homo sapiens_hsa05210	0.41450626
91	Circadian rhythm_Homo sapiens_hsa04710	0.41094656
92	Rap1 signaling pathway_Homo sapiens_hsa04015	0.40796453
93	Dopaminergic synapse_Homo sapiens_hsa04728	0.39790505
94	Histidine metabolism_Homo sapiens_hsa00340	0.38546348
95	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.38493646
96	Spliceosome_Homo sapiens_hsa03040	0.37911953
97	Long-term depression_Homo sapiens_hsa04730	0.37695168
98	Chemical carcinogenesis_Homo sapiens_hsa05204	0.36149484
99	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.35649481
100	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.34747302

FAM90A25P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »