ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	short-term memory (GO:0007614)	6.35819613
2	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	5.91038091
3	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	5.77226840
4	chemosensory behavior (GO:0007635)	5.41582639
5	mitochondrion distribution (GO:0048311)	5.24922674
6	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	5.08406588
7	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	5.08406588
8	regulation of penile erection (GO:0060405)	4.98910973
9	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	4.90030972
10	specification of organ identity (GO:0010092)	4.88543302
11	response to histamine (GO:0034776)	4.87551234
12	hindbrain development (GO:0030902)	4.55375584
13	pyrimidine nucleobase catabolic process (GO:0006208)	4.53449312
14	regulation of neurotransmitter uptake (GO:0051580)	4.37155513
15	behavioral response to ethanol (GO:0048149)	4.22192641
16	postsynaptic membrane organization (GO:0001941)	4.19336765
17	gamma-aminobutyric acid transport (GO:0015812)	4.14367499
18	behavioral response to cocaine (GO:0048148)	4.02301419
19	presynaptic membrane assembly (GO:0097105)	3.94479941
20	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.93025871
21	establishment of mitochondrion localization (GO:0051654)	3.82278461
22	establishment of protein localization to Golgi (GO:0072600)	3.80446615
23	multicellular organism reproduction (GO:0032504)	3.79158433
24	protein targeting to Golgi (GO:0000042)	3.72956422
25	positive regulation of membrane potential (GO:0045838)	3.72654532
26	neuron cell-cell adhesion (GO:0007158)	3.65764372
27	mitochondrion localization (GO:0051646)	3.55571965
28	nucleobase catabolic process (GO:0046113)	3.52751562
29	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.50639568
30	dendritic spine morphogenesis (GO:0060997)	3.49925531
31	presynaptic membrane organization (GO:0097090)	3.49823040
32	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.48782118
33	mitochondrion transport along microtubule (GO:0047497)	3.48436394
34	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.48436394
35	vocalization behavior (GO:0071625)	3.47209309
36	regulation of voltage-gated calcium channel activity (GO:1901385)	3.46956453
37	positive regulation of amine transport (GO:0051954)	3.45544886
38	adaptation of signaling pathway (GO:0023058)	3.45425628
39	response to pheromone (GO:0019236)	3.44192741
40	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.39826875
41	positive regulation of neurotransmitter transport (GO:0051590)	3.37708358
42	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.36440022
43	exploration behavior (GO:0035640)	3.34728197
44	transmission of nerve impulse (GO:0019226)	3.34118242
45	prenylation (GO:0097354)	3.31781585
46	protein prenylation (GO:0018342)	3.31781585
47	membrane hyperpolarization (GO:0060081)	3.31276417
48	membrane depolarization during action potential (GO:0086010)	3.30094098
49	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.29754401
50	behavioral response to nicotine (GO:0035095)	3.24077803
51	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.17463994
52	behavioral fear response (GO:0001662)	3.16399166
53	behavioral defense response (GO:0002209)	3.16399166
54	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.14658563
55	positive regulation of sodium ion transmembrane transport (GO:1902307)	3.14158265
56	neuron recognition (GO:0008038)	3.11419573
57	negative regulation of cAMP biosynthetic process (GO:0030818)	3.08190735
58	positive regulation of action potential (GO:0045760)	3.07965100
59	neuron-neuron synaptic transmission (GO:0007270)	3.07900713
60	negative regulation of cAMP metabolic process (GO:0030815)	3.06346228
61	cilium or flagellum-dependent cell motility (GO:0001539)	3.05056759
62	regulation of collateral sprouting (GO:0048670)	3.04995872
63	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.03116327
64	regulation of synaptic transmission, dopaminergic (GO:0032225)	3.01672180
65	negative regulation of adenylate cyclase activity (GO:0007194)	2.98703546
66	negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)	2.95036053
67	negative regulation of cyclic nucleotide metabolic process (GO:0030800)	2.94371790
68	protein localization to synapse (GO:0035418)	2.93377260
69	auditory behavior (GO:0031223)	2.90807954
70	icosanoid secretion (GO:0032309)	2.89353135
71	arachidonic acid secretion (GO:0050482)	2.89353135
72	adult walking behavior (GO:0007628)	2.88793315
73	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.88399540
74	neuronal action potential propagation (GO:0019227)	2.87654633
75	positive regulation of protein homodimerization activity (GO:0090073)	2.87083428
76	regulation of action potential (GO:0098900)	2.84520755
77	synaptic vesicle maturation (GO:0016188)	2.83291159
78	locomotory exploration behavior (GO:0035641)	2.82738304
79	neurotransmitter-gated ion channel clustering (GO:0072578)	2.82440961
80	negative regulation of cyclase activity (GO:0031280)	2.81559269
81	glutamate secretion (GO:0014047)	2.79981692
82	retinal ganglion cell axon guidance (GO:0031290)	2.79691334
83	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.79205028
84	protein localization to Golgi apparatus (GO:0034067)	2.77863063
85	negative regulation of nucleotide biosynthetic process (GO:0030809)	2.76343758
86	negative regulation of purine nucleotide biosynthetic process (GO:1900372)	2.76343758
87	neuronal ion channel clustering (GO:0045161)	2.74871344
88	fear response (GO:0042596)	2.74643768
89	regulation of excitatory postsynaptic membrane potential (GO:0060079)	2.74068417
90	forebrain neuron differentiation (GO:0021879)	2.72481765
91	response to misfolded protein (GO:0051788)	2.70080158
92	regulation of postsynaptic membrane potential (GO:0060078)	2.69653662
93	synaptic transmission, dopaminergic (GO:0001963)	2.68406898
94	retina development in camera-type eye (GO:0060041)	2.68291742
95	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.66355524
96	membrane depolarization (GO:0051899)	2.66045872
97	negative regulation of lyase activity (GO:0051350)	2.64726545
98	retinal cone cell development (GO:0046549)	2.64380015
99	axonal fasciculation (GO:0007413)	2.62254681
100	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.62188092

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.25230437
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.19673567
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.77006929
4	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.47640691
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.31244815
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.94012094
7	VDR_22108803_ChIP-Seq_LS180_Human	2.43274118
8	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.39734975
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.35637740
10	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.31099221
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.29974050
12	REST_21632747_ChIP-Seq_MESCs_Mouse	2.29628325
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.21382508
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.20918885
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.15291924
16	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.15233852
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.15203212
18	TAF15_26573619_Chip-Seq_HEK293_Human	2.08127766
19	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.04982344
20	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.04724397
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04198072
22	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.02306844
23	DROSHA_22980978_ChIP-Seq_HELA_Human	2.01017571
24	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.00947958
25	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.96903273
26	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.95841363
27	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.95792412
28	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.88198410
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.85297356
30	SMAD4_21799915_ChIP-Seq_A2780_Human	1.83651350
31	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.81965123
32	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.77743467
33	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.75675967
34	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.72874068
35	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.69318270
36	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.66690895
37	P300_19829295_ChIP-Seq_ESCs_Human	1.66614139
38	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.64433697
39	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.64433697
40	AR_21572438_ChIP-Seq_LNCaP_Human	1.63816866
41	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.62194710
42	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.61175070
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60363623
44	RNF2_27304074_Chip-Seq_NSC_Mouse	1.60066161
45	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.59812953
46	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.51165419
47	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.50776301
48	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.47255592
49	FUS_26573619_Chip-Seq_HEK293_Human	1.46898366
50	AR_25329375_ChIP-Seq_VCAP_Human	1.45648937
51	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.45593306
52	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.44286010
53	STAT3_23295773_ChIP-Seq_U87_Human	1.41555193
54	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.40776439
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.40390752
56	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.40216766
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38478012
58	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.34315722
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.33960183
60	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.32641573
61	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31019346
62	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.27787215
63	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.25273169
64	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21901276
65	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21901276
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.21433075
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21433075
68	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21273161
69	TCF4_23295773_ChIP-Seq_U87_Human	1.21115000
70	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18166413
71	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.16159460
72	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.16051127
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.15402196
74	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.14486823
75	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.14294763
76	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11538679
77	EWS_26573619_Chip-Seq_HEK293_Human	1.11311427
78	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.09968871
79	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.07346142
80	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06662981
81	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05312206
82	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.03210001
83	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.02884616
84	ER_23166858_ChIP-Seq_MCF-7_Human	1.02713865
85	BCAT_22108803_ChIP-Seq_LS180_Human	1.02625804
86	AR_19668381_ChIP-Seq_PC3_Human	1.02333640
87	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.00444612
88	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.00384346
89	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.00078440
90	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.97427358
91	TCF4_22108803_ChIP-Seq_LS180_Human	0.96616036
92	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.94474998
93	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.94012486
94	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.93621042
95	TBL1_22424771_ChIP-Seq_293T_Human	0.93005104
96	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.92396823
97	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.92282267
98	STAT1_17558387_ChIP-Seq_HELA_Human	0.91954927
99	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.91340506
100	AHR_22903824_ChIP-Seq_MCF-7_Human	0.91044502

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	4.78165961
2	MP0005423_abnormal_somatic_nervous	3.27481537
3	MP0004270_analgesia	3.02873305
4	MP0001984_abnormal_olfaction	3.00898445
5	MP0003635_abnormal_synaptic_transmissio	2.77026386
6	MP0009745_abnormal_behavioral_response	2.45056660
7	MP0000778_abnormal_nervous_system	2.45034718
8	MP0003880_abnormal_central_pattern	2.44826413
9	MP0006292_abnormal_olfactory_placode	2.38190200
10	MP0001529_abnormal_vocalization	2.38151423
11	MP0002272_abnormal_nervous_system	2.31283120
12	MP0005499_abnormal_olfactory_system	2.26790551
13	MP0005394_taste/olfaction_phenotype	2.26790551
14	MP0001486_abnormal_startle_reflex	2.23433328
15	MP0002735_abnormal_chemical_nociception	2.20486776
16	MP0008877_abnormal_DNA_methylation	2.15218832
17	MP0008789_abnormal_olfactory_epithelium	2.13132455
18	MP0002063_abnormal_learning/memory/cond	2.12897903
19	MP0002572_abnormal_emotion/affect_behav	2.11117233
20	MP0001968_abnormal_touch/_nociception	2.08082025
21	MP0002734_abnormal_mechanical_nocicepti	2.03041522
22	MP0002064_seizures	1.96174176
23	MP0009046_muscle_twitch	1.93792859
24	MP0006276_abnormal_autonomic_nervous	1.85793416
25	MP0005551_abnormal_eye_electrophysiolog	1.82722146
26	MP0001986_abnormal_taste_sensitivity	1.78560642
27	MP0003879_abnormal_hair_cell	1.77074874
28	MP0001485_abnormal_pinna_reflex	1.72945259
29	MP0004885_abnormal_endolymph	1.69128222
30	MP0003122_maternal_imprinting	1.64481254
31	MP0000955_abnormal_spinal_cord	1.63604940
32	MP0002736_abnormal_nociception_after	1.61359759
33	MP0001905_abnormal_dopamine_level	1.59124874
34	MP0002067_abnormal_sensory_capabilities	1.53130030
35	MP0002882_abnormal_neuron_morphology	1.53072067
36	MP0004811_abnormal_neuron_physiology	1.49975918
37	MP0002102_abnormal_ear_morphology	1.47157043
38	MP0000049_abnormal_middle_ear	1.46639902
39	MP0002638_abnormal_pupillary_reflex	1.44427594
40	MP0000462_abnormal_digestive_system	1.37850197
41	MP0002752_abnormal_somatic_nervous	1.36845776
42	MP0002233_abnormal_nose_morphology	1.36808906
43	MP0004133_heterotaxia	1.36285187
44	MP0001970_abnormal_pain_threshold	1.34748686
45	MP0002751_abnormal_autonomic_nervous	1.34712673
46	MP0004742_abnormal_vestibular_system	1.33728357
47	MP0005410_abnormal_fertilization	1.32458041
48	MP0005253_abnormal_eye_physiology	1.31896204
49	MP0002733_abnormal_thermal_nociception	1.30542790
50	MP0000026_abnormal_inner_ear	1.30150630
51	MP0002184_abnormal_innervation	1.29526843
52	MP0001963_abnormal_hearing_physiology	1.27196497
53	MP0000631_abnormal_neuroendocrine_gland	1.26815853
54	MP0002822_catalepsy	1.26785852
55	MP0003698_abnormal_male_reproductive	1.25557631
56	MP0002557_abnormal_social/conspecific_i	1.24161813
57	MP0001501_abnormal_sleep_pattern	1.23420333
58	MP0002234_abnormal_pharynx_morphology	1.23009682
59	MP0002160_abnormal_reproductive_system	1.15420679
60	MP0002152_abnormal_brain_morphology	1.14308561
61	MP0003121_genomic_imprinting	1.13696738
62	MP0003633_abnormal_nervous_system	1.13369358
63	MP0001440_abnormal_grooming_behavior	1.13343516
64	MP0002229_neurodegeneration	1.12489336
65	MP0005386_behavior/neurological_phenoty	1.10477922
66	MP0004924_abnormal_behavior	1.10477922
67	MP0001502_abnormal_circadian_rhythm	1.09560956
68	MP0002069_abnormal_eating/drinking_beha	1.06024537
69	MP0001293_anophthalmia	1.03133348
70	MP0004142_abnormal_muscle_tone	1.02849336
71	MP0002066_abnormal_motor_capabilities/c	1.02559713
72	MP0006072_abnormal_retinal_apoptosis	1.02422038
73	MP0001929_abnormal_gametogenesis	1.00863115
74	MP0005084_abnormal_gallbladder_morpholo	0.98401363
75	MP0008995_early_reproductive_senescence	0.98026315
76	MP0005391_vision/eye_phenotype	0.92084343
77	MP0003787_abnormal_imprinting	0.91704574
78	MP0003631_nervous_system_phenotype	0.91630884
79	MP0001177_atelectasis	0.91203421
80	MP0004134_abnormal_chest_morphology	0.90621442
81	MP0005195_abnormal_posterior_eye	0.89540474
82	MP0002090_abnormal_vision	0.88216119
83	MP0003136_yellow_coat_color	0.86556829
84	MP0002210_abnormal_sex_determination	0.84306299
85	MP0003861_abnormal_nervous_system	0.83665719
86	MP0000678_abnormal_parathyroid_gland	0.83456037
87	MP0005187_abnormal_penis_morphology	0.81498859
88	MP0003938_abnormal_ear_development	0.75671349
89	MP0003567_abnormal_fetal_cardiomyocyte	0.75544472
90	MP0002653_abnormal_ependyma_morphology	0.74504591
91	MP0002161_abnormal_fertility/fecundity	0.73628086
92	MP0001299_abnormal_eye_distance/	0.71473726
93	MP0002132_abnormal_respiratory_system	0.71147256
94	MP0003755_abnormal_palate_morphology	0.71051622
95	MP0004043_abnormal_pH_regulation	0.70616984
96	MP0003119_abnormal_digestive_system	0.70604049
97	MP0003385_abnormal_body_wall	0.69390462
98	MP0000653_abnormal_sex_gland	0.68803791
99	MP0010386_abnormal_urinary_bladder	0.68439851
100	MP0004085_abnormal_heartbeat	0.68089391

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Atonic seizures (HP:0010819)	4.94969435
2	Myokymia (HP:0002411)	4.50931993
3	Focal seizures (HP:0007359)	3.98350581
4	Septo-optic dysplasia (HP:0100842)	3.93831148
5	Retinal atrophy (HP:0001105)	3.93034356
6	Poor eye contact (HP:0000817)	3.45768543
7	Action tremor (HP:0002345)	3.45645180
8	Focal motor seizures (HP:0011153)	3.27192195
9	Optic nerve hypoplasia (HP:0000609)	3.25120742
10	Febrile seizures (HP:0002373)	3.22004647
11	Gait imbalance (HP:0002141)	3.20552914
12	Absent speech (HP:0001344)	3.13233314
13	Dialeptic seizures (HP:0011146)	3.06983512
14	Fetal akinesia sequence (HP:0001989)	3.03073102
15	Chronic hepatic failure (HP:0100626)	2.87019005
16	Abnormal social behavior (HP:0012433)	2.86887815
17	Impaired social interactions (HP:0000735)	2.86887815
18	Nephronophthisis (HP:0000090)	2.86143394
19	Medial flaring of the eyebrow (HP:0010747)	2.85965147
20	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.84485183
21	Broad-based gait (HP:0002136)	2.83369980
22	Epileptiform EEG discharges (HP:0011182)	2.79352089
23	Generalized tonic-clonic seizures (HP:0002069)	2.76668910
24	Esotropia (HP:0000565)	2.76070246
25	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.74554933
26	Polyphagia (HP:0002591)	2.71955989
27	Absent/shortened dynein arms (HP:0200106)	2.71687619
28	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.71687619
29	EEG with generalized epileptiform discharges (HP:0011198)	2.71597901
30	Abnormal ciliary motility (HP:0012262)	2.71349306
31	Absence seizures (HP:0002121)	2.70314106
32	Failure to thrive in infancy (HP:0001531)	2.69041483
33	Retinal dysplasia (HP:0007973)	2.64817276
34	Nephrogenic diabetes insipidus (HP:0009806)	2.64549233
35	Hypsarrhythmia (HP:0002521)	2.64310297
36	Congenital stationary night blindness (HP:0007642)	2.63428279
37	Abnormality of the septum pellucidum (HP:0007375)	2.58838733
38	Pachygyria (HP:0001302)	2.58688801
39	Absent septum pellucidum (HP:0001331)	2.53980521
40	Congenital primary aphakia (HP:0007707)	2.53761058
41	Drooling (HP:0002307)	2.50752118
42	Protruding tongue (HP:0010808)	2.46884231
43	Lissencephaly (HP:0001339)	2.45507836
44	Abnormal respiratory motile cilium morphology (HP:0005938)	2.45242797
45	Abnormal respiratory epithelium morphology (HP:0012253)	2.45242797
46	Hepatoblastoma (HP:0002884)	2.42409140
47	Genital tract atresia (HP:0001827)	2.36846453
48	Abnormal respiratory motile cilium physiology (HP:0012261)	2.35070429
49	Shawl scrotum (HP:0000049)	2.33800495
50	Progressive cerebellar ataxia (HP:0002073)	2.33338140
51	High anterior hairline (HP:0009890)	2.33260453
52	Hyperventilation (HP:0002883)	2.30987092
53	Vaginal atresia (HP:0000148)	2.30965474
54	Abnormality of the columella (HP:0009929)	2.29170543
55	Severe muscular hypotonia (HP:0006829)	2.27663264
56	Neoplasm of the adrenal cortex (HP:0100641)	2.27592304
57	Excessive salivation (HP:0003781)	2.26461652
58	Abnormality of the renal medulla (HP:0100957)	2.23042526
59	Amyotrophic lateral sclerosis (HP:0007354)	2.22540170
60	Epileptic encephalopathy (HP:0200134)	2.20756211
61	Poor coordination (HP:0002370)	2.20311578
62	Partial agenesis of the corpus callosum (HP:0001338)	2.20215540
63	Gaze-evoked nystagmus (HP:0000640)	2.20154717
64	Tubular atrophy (HP:0000092)	2.19192578
65	Pancreatic fibrosis (HP:0100732)	2.18762551
66	Apathy (HP:0000741)	2.15540598
67	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.14818237
68	True hermaphroditism (HP:0010459)	2.14410694
69	Occipital encephalocele (HP:0002085)	2.11847424
70	Megalencephaly (HP:0001355)	2.10256953
71	Abnormality of the labia minora (HP:0012880)	2.09593201
72	Amblyopia (HP:0000646)	2.09077092
73	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.08563934
74	Hypoplasia of the brainstem (HP:0002365)	2.08563934
75	Abnormal eating behavior (HP:0100738)	2.04839861
76	Oligodactyly (hands) (HP:0001180)	2.04067502
77	Tongue fasciculations (HP:0001308)	2.01806875
78	Abnormal rod and cone electroretinograms (HP:0008323)	2.01738667
79	Anencephaly (HP:0002323)	2.01618568
80	Aqueductal stenosis (HP:0002410)	1.96769066
81	Abnormality of midbrain morphology (HP:0002418)	1.96763462
82	Molar tooth sign on MRI (HP:0002419)	1.96763462
83	Limb dystonia (HP:0002451)	1.94928435
84	Poor suck (HP:0002033)	1.92969146
85	Hemiparesis (HP:0001269)	1.92704936
86	Diminished motivation (HP:0000745)	1.89615056
87	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.89019433
88	Vitreoretinal degeneration (HP:0000655)	1.87450416
89	Tented upper lip vermilion (HP:0010804)	1.87053277
90	Renal dysplasia (HP:0000110)	1.85775182
91	Tubulointerstitial nephritis (HP:0001970)	1.82427875
92	Sleep apnea (HP:0010535)	1.79462737
93	Truncal obesity (HP:0001956)	1.79176066
94	Abnormality of the parathyroid morphology (HP:0011766)	1.78212624
95	Aplasia/Hypoplasia of the lens (HP:0008063)	1.78127254
96	Hypoplastic pelvis (HP:0008839)	1.77089449
97	Intellectual disability, moderate (HP:0002342)	1.75896442
98	Delusions (HP:0000746)	1.72255150
99	Submucous cleft hard palate (HP:0000176)	1.71891463
100	Thoracic kyphosis (HP:0002942)	1.70962311

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PRPF4B	5.64758667
2	CDK19	5.45325359
3	MARK1	3.76859109
4	TAOK2	3.72562158
5	CASK	3.67905918
6	MAP3K4	2.58743039
7	FRK	2.41365520
8	MAP2K7	2.38969508
9	MAP4K2	2.20453205
10	WNK3	2.16337388
11	MAPK13	2.15530240
12	PINK1	2.14518399
13	EPHA4	1.74095496
14	NTRK2	1.72868032
15	DYRK2	1.64609690
16	NTRK3	1.60141651
17	BRD4	1.55315556
18	PKN1	1.52546586
19	FGFR2	1.39812652
20	PLK2	1.29030257
21	SGK223	1.26899783
22	SGK494	1.26899783
23	OXSR1	1.26409345
24	STK38L	1.25527459
25	TNIK	1.24951064
26	BMPR1B	1.21902842
27	PRKCG	1.17989969
28	EEF2K	1.16592839
29	CDK3	1.09604188
30	MAP2K4	1.05082580
31	PHKG2	1.00870960
32	PHKG1	1.00870960
33	UHMK1	0.98900346
34	MARK2	0.98327663
35	MAP3K6	0.94012692
36	INSRR	0.92355902
37	CDK5	0.90881386
38	MINK1	0.88199799
39	PRKD3	0.87849696
40	PRKAA1	0.85689169
41	CCNB1	0.84585292
42	CSNK1A1L	0.83099743
43	MAP3K5	0.82020041
44	NEK2	0.81715908
45	DAPK1	0.77680292
46	DAPK2	0.77497646
47	CAMK1D	0.72751180
48	GRK1	0.72412799
49	CSNK1G2	0.72164103
50	STK38	0.72008593
51	TRIM28	0.71806453
52	SGK2	0.69358013
53	TYRO3	0.68776963
54	BCR	0.68381709
55	CAMK1	0.67516214
56	MAPK12	0.66409000
57	CAMK4	0.66309123
58	CAMK1G	0.63762410
59	CSNK1G3	0.62691237
60	CAMK2A	0.60396532
61	CSNK1G1	0.57356023
62	CDK11A	0.56510575
63	RPS6KA5	0.56478018
64	MAPKAPK3	0.56153991
65	PLK4	0.53637371
66	PRKCZ	0.53623406
67	FLT3	0.53193947
68	SGK1	0.51190422
69	PRKCE	0.50530195
70	ZAK	0.50167689
71	MAPK15	0.48485778
72	CSNK1A1	0.47994279
73	PLK1	0.47958789
74	CAMK2B	0.47908984
75	TIE1	0.47551304
76	PRKG1	0.45366625
77	CDK14	0.44996621
78	ERBB4	0.44131758
79	CDK18	0.43716010
80	CDK15	0.43646847
81	RPS6KA2	0.42873289
82	MAP3K7	0.42770384
83	NTRK1	0.40476736
84	CSNK1E	0.39515692
85	AKT3	0.38789168
86	PTK2B	0.38441494
87	MAPK9	0.38425418
88	ADRBK2	0.37855014
89	MAP3K9	0.37606155
90	RPS6KB1	0.35330246
91	OBSCN	0.35291260
92	CSNK1D	0.33477366
93	AKT2	0.33154687
94	STK11	0.32961541
95	PRKCB	0.31837667
96	DYRK1B	0.31760043
97	GSK3B	0.30997939
98	PNCK	0.30952609
99	ILK	0.30826883
100	DYRK1A	0.30600005

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.85330311
2	GABAergic synapse_Homo sapiens_hsa04727	2.93103912
3	Phototransduction_Homo sapiens_hsa04744	2.89743636
4	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.73484704
5	Morphine addiction_Homo sapiens_hsa05032	2.55847984
6	Taste transduction_Homo sapiens_hsa04742	2.36916201
7	Glutamatergic synapse_Homo sapiens_hsa04724	2.29091177
8	Dopaminergic synapse_Homo sapiens_hsa04728	2.19803337
9	Olfactory transduction_Homo sapiens_hsa04740	2.12817913
10	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.09164356
11	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.01146664
12	Circadian entrainment_Homo sapiens_hsa04713	2.00524263
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.95188993
14	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.94478034
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.90136617
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.80640239
17	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.72262626
18	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.59116096
19	Insulin secretion_Homo sapiens_hsa04911	1.55667828
20	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.49145674
21	Axon guidance_Homo sapiens_hsa04360	1.48773166
22	Cholinergic synapse_Homo sapiens_hsa04725	1.47619390
23	Cocaine addiction_Homo sapiens_hsa05030	1.41594671
24	Bile secretion_Homo sapiens_hsa04976	1.37403445
25	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.32588202
26	Amphetamine addiction_Homo sapiens_hsa05031	1.27113299
27	Salivary secretion_Homo sapiens_hsa04970	1.26754597
28	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.26630027
29	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.26432339
30	Oocyte meiosis_Homo sapiens_hsa04114	1.25274317
31	Basal transcription factors_Homo sapiens_hsa03022	1.22378527
32	Calcium signaling pathway_Homo sapiens_hsa04020	1.21806269
33	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.21046139
34	cAMP signaling pathway_Homo sapiens_hsa04024	1.14982635
35	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.09158821
36	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.09009526
37	Serotonergic synapse_Homo sapiens_hsa04726	1.06652755
38	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.02204706
39	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.01260515
40	Butanoate metabolism_Homo sapiens_hsa00650	1.00446047
41	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.99696730
42	ErbB signaling pathway_Homo sapiens_hsa04012	0.97400135
43	Gap junction_Homo sapiens_hsa04540	0.92947725
44	Gastric acid secretion_Homo sapiens_hsa04971	0.88532958
45	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.88012500
46	Long-term potentiation_Homo sapiens_hsa04720	0.87347283
47	Ras signaling pathway_Homo sapiens_hsa04014	0.82749725
48	Regulation of autophagy_Homo sapiens_hsa04140	0.81371416
49	Hippo signaling pathway_Homo sapiens_hsa04390	0.80747625
50	Renin secretion_Homo sapiens_hsa04924	0.78574405
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.77241737
52	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.73886130
53	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.73856622
54	ABC transporters_Homo sapiens_hsa02010	0.73216122
55	Type II diabetes mellitus_Homo sapiens_hsa04930	0.72547466
56	Endometrial cancer_Homo sapiens_hsa05213	0.70905159
57	Lysine degradation_Homo sapiens_hsa00310	0.68937287
58	Nitrogen metabolism_Homo sapiens_hsa00910	0.67557812
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67456913
60	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.67014038
61	MAPK signaling pathway_Homo sapiens_hsa04010	0.66329711
62	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.66179955
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.65298682
64	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.63914006
65	Wnt signaling pathway_Homo sapiens_hsa04310	0.62992074
66	Ether lipid metabolism_Homo sapiens_hsa00565	0.62280282
67	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.59152983
68	Linoleic acid metabolism_Homo sapiens_hsa00591	0.58301410
69	Pancreatic secretion_Homo sapiens_hsa04972	0.57853192
70	Alcoholism_Homo sapiens_hsa05034	0.57428076
71	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.56800623
72	Fanconi anemia pathway_Homo sapiens_hsa03460	0.55126938
73	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.54023077
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.53329927
75	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.53146354
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52300127
77	Long-term depression_Homo sapiens_hsa04730	0.52208666
78	Retinol metabolism_Homo sapiens_hsa00830	0.51661424
79	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.51345938
80	Rap1 signaling pathway_Homo sapiens_hsa04015	0.48683036
81	Peroxisome_Homo sapiens_hsa04146	0.48613612
82	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.48321541
83	Steroid biosynthesis_Homo sapiens_hsa00100	0.47803445
84	Choline metabolism in cancer_Homo sapiens_hsa05231	0.47274830
85	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.46943722
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46729073
87	Basal cell carcinoma_Homo sapiens_hsa05217	0.46370238
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46280283
89	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.44627804
90	Melanogenesis_Homo sapiens_hsa04916	0.43576734
91	AMPK signaling pathway_Homo sapiens_hsa04152	0.42855930
92	Sulfur relay system_Homo sapiens_hsa04122	0.42659022
93	Estrogen signaling pathway_Homo sapiens_hsa04915	0.41668274
94	Melanoma_Homo sapiens_hsa05218	0.38556221
95	GnRH signaling pathway_Homo sapiens_hsa04912	0.38221418
96	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.36845815
97	Colorectal cancer_Homo sapiens_hsa05210	0.34760739
98	mTOR signaling pathway_Homo sapiens_hsa04150	0.34631521
99	Tight junction_Homo sapiens_hsa04530	0.33506070
100	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.33029450

FAM90A2P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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