FAM91A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.77580307
2COPI coating of Golgi vesicle (GO:0048205)4.77580307
3hepatocyte apoptotic process (GO:0097284)4.11533081
4hypotonic response (GO:0006971)3.61384979
5negative regulation of fibrinolysis (GO:0051918)3.55900057
6nuclear pore complex assembly (GO:0051292)3.53324685
7cysteine metabolic process (GO:0006534)3.48245421
8cell adhesion mediated by integrin (GO:0033627)3.45996450
9response to peptidoglycan (GO:0032494)3.45360256
10activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.41266194
11COPII vesicle coating (GO:0048208)3.38014328
12alpha-linolenic acid metabolic process (GO:0036109)3.35643473
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.35137783
14positive regulation of keratinocyte differentiation (GO:0045618)3.34123867
15positive regulation of nuclease activity (GO:0032075)3.28688835
16protein carboxylation (GO:0018214)3.27661932
17peptidyl-glutamic acid carboxylation (GO:0017187)3.27661932
18nuclear pore organization (GO:0006999)3.25448636
19apoptotic cell clearance (GO:0043277)3.24893772
20urea metabolic process (GO:0019627)3.22475847
21urea cycle (GO:0000050)3.22475847
22necroptotic process (GO:0070266)3.21915933
23definitive hemopoiesis (GO:0060216)3.18699733
24regulation of cholesterol homeostasis (GO:2000188)3.17895196
25mammary gland epithelial cell proliferation (GO:0033598)3.12201659
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.11887219
27L-phenylalanine catabolic process (GO:0006559)3.11887219
28endoplasmic reticulum unfolded protein response (GO:0030968)3.10580666
29sulfur amino acid catabolic process (GO:0000098)3.03983429
30homocysteine metabolic process (GO:0050667)3.03806707
31mitotic sister chromatid cohesion (GO:0007064)3.02980961
32regulation of nuclease activity (GO:0032069)2.99112169
33erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.96743856
34L-phenylalanine metabolic process (GO:0006558)2.96743856
35cellular response to unfolded protein (GO:0034620)2.94925416
364-hydroxyproline metabolic process (GO:0019471)2.94597319
37ER-nucleus signaling pathway (GO:0006984)2.92049595
38ER overload response (GO:0006983)2.91396421
39complement activation, alternative pathway (GO:0006957)2.88453979
40protein retention in ER lumen (GO:0006621)2.87828525
41regulation of keratinocyte differentiation (GO:0045616)2.87547448
42regulation of fatty acid beta-oxidation (GO:0031998)2.86940608
43protein localization to endosome (GO:0036010)2.86852387
44low-density lipoprotein particle clearance (GO:0034383)2.86419122
45retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.86369538
46membrane raft organization (GO:0031579)2.85816776
47triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.85450181
48regulation of fibrinolysis (GO:0051917)2.85110463
49cellular response to ethanol (GO:0071361)2.82368651
50intestinal cholesterol absorption (GO:0030299)2.80654480
51regulation of protein activation cascade (GO:2000257)2.77791227
52hippo signaling (GO:0035329)2.76960779
53epithelial cell differentiation involved in prostate gland development (GO:0060742)2.76388636
54positive regulation of fatty acid beta-oxidation (GO:0032000)2.75608035
55regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.74261115
56nitrogen cycle metabolic process (GO:0071941)2.71780355
57activation of Rac GTPase activity (GO:0032863)2.71514275
58negative regulation of fatty acid transport (GO:2000192)2.71155577
59hormone catabolic process (GO:0042447)2.70908149
60cellular response to topologically incorrect protein (GO:0035967)2.69496489
61cytoplasmic mRNA processing body assembly (GO:0033962)2.68756510
62growth hormone receptor signaling pathway (GO:0060396)2.68402279
63positive regulation of SMAD protein import into nucleus (GO:0060391)2.67884721
64midgut development (GO:0007494)2.67747930
65cellular glucuronidation (GO:0052695)2.67222901
66folic acid-containing compound biosynthetic process (GO:0009396)2.66810824
67regulation of complement activation (GO:0030449)2.66596862
68regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.66340126
69vesicle coating (GO:0006901)2.66303243
70insulin-like growth factor receptor signaling pathway (GO:0048009)2.63234157
71lipoprotein metabolic process (GO:0042157)2.62881602
72negative regulation of DNA repair (GO:0045738)2.62850418
73macroautophagy (GO:0016236)2.62722706
74regulation of histone H3-K27 methylation (GO:0061085)2.62533320
75negative regulation of lipid transport (GO:0032369)2.61737691
76histone H3-K36 demethylation (GO:0070544)2.61516767
77epoxygenase P450 pathway (GO:0019373)2.61029290
78germ cell migration (GO:0008354)2.59767668
79reverse cholesterol transport (GO:0043691)2.59552488
80pore complex assembly (GO:0046931)2.59105984
81aromatic amino acid family catabolic process (GO:0009074)2.58303046
82TOR signaling (GO:0031929)2.57274516
83high-density lipoprotein particle remodeling (GO:0034375)2.55910649
84glucocorticoid receptor signaling pathway (GO:0042921)2.55425663
85desmosome organization (GO:0002934)2.55014838
86intestinal absorption (GO:0050892)2.53649877
87pinocytosis (GO:0006907)2.53116795
88positive regulation of macrophage differentiation (GO:0045651)2.52168428
89glycine metabolic process (GO:0006544)2.52080865
90negative regulation of protein localization to plasma membrane (GO:1903077)2.51519228
91lysine metabolic process (GO:0006553)2.51336606
92lysine catabolic process (GO:0006554)2.51336606
93response to nitrosative stress (GO:0051409)2.51233418
94negative regulation of sterol transport (GO:0032372)2.50706689
95negative regulation of cholesterol transport (GO:0032375)2.50706689
96plasma lipoprotein particle clearance (GO:0034381)2.50191982
97skin morphogenesis (GO:0043589)2.50175316
98protein-lipid complex assembly (GO:0065005)2.49790766
99cellular modified amino acid catabolic process (GO:0042219)2.49339985
100iron ion import (GO:0097286)2.48719748
101regulation of necroptotic process (GO:0060544)2.47382619
102UDP-N-acetylglucosamine metabolic process (GO:0006047)2.47295823
103lipopolysaccharide-mediated signaling pathway (GO:0031663)2.47282748
104L-alpha-amino acid transmembrane transport (GO:1902475)2.47130639
105detection of molecule of bacterial origin (GO:0032490)2.46748490
106positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.46448862
107regulation of SMAD protein import into nucleus (GO:0060390)2.45816367
108barbed-end actin filament capping (GO:0051016)2.45148239
109ribosome assembly (GO:0042255)2.44018305
110endodermal cell differentiation (GO:0035987)2.43939954
111response to endoplasmic reticulum stress (GO:0034976)2.43929046
112phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.43009871
113one-carbon metabolic process (GO:0006730)2.42833360
114bile acid biosynthetic process (GO:0006699)2.40514346
115positive regulation of epidermal cell differentiation (GO:0045606)2.40196295
116chondrocyte development (GO:0002063)2.39447452
117fibrinolysis (GO:0042730)2.39443874
118negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.39289590
119hemidesmosome assembly (GO:0031581)2.39097448
120heterochromatin organization (GO:0070828)2.39025547
121serine family amino acid catabolic process (GO:0009071)2.38274490
122serine family amino acid metabolic process (GO:0009069)2.38066809
123receptor catabolic process (GO:0032801)2.37949981
124cellular extravasation (GO:0045123)2.37500990
125positive regulation of protein import into nucleus, translocation (GO:0033160)2.37205316
126programmed necrotic cell death (GO:0097300)2.36936724
127regulation of plasminogen activation (GO:0010755)2.36738604
128regulation of translational fidelity (GO:0006450)2.35456455
129necrotic cell death (GO:0070265)2.34639434
130plasma lipoprotein particle assembly (GO:0034377)2.34401723
131negative regulation of necroptotic process (GO:0060546)2.34230312
132regulation of RNA export from nucleus (GO:0046831)2.34224635
133germinal center formation (GO:0002467)2.33871680
134regulation of transforming growth factor beta1 production (GO:0032908)2.33765130
135regulation of transforming growth factor beta2 production (GO:0032909)2.32710706
136embryonic process involved in female pregnancy (GO:0060136)2.31818769
137tyrosine metabolic process (GO:0006570)2.31430215
138serine family amino acid biosynthetic process (GO:0009070)2.31207454
139collagen fibril organization (GO:0030199)2.30993077
140regulation of nucleobase-containing compound transport (GO:0032239)2.30724996
141positive regulation of Cdc42 GTPase activity (GO:0043089)2.28278855
142positive regulation of interferon-alpha production (GO:0032727)2.27272824
143regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.27039869
144antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.26931352
145intestinal epithelial cell development (GO:0060576)2.25746517
146response to muramyl dipeptide (GO:0032495)2.23945363
147cell-substrate junction assembly (GO:0007044)2.23054927
148membrane protein ectodomain proteolysis (GO:0006509)2.20681276
149cortical actin cytoskeleton organization (GO:0030866)2.20613312
150positive regulation of leukocyte degranulation (GO:0043302)2.19914131
151oligosaccharide catabolic process (GO:0009313)2.18600067
152early endosome to late endosome transport (GO:0045022)2.17827203
153branching involved in mammary gland duct morphogenesis (GO:0060444)2.17383262
154response to laminar fluid shear stress (GO:0034616)2.15406353
155negative regulation of anoikis (GO:2000811)2.14614298
156negative regulation of erythrocyte differentiation (GO:0045647)2.12771258
157establishment of endothelial barrier (GO:0061028)2.12037440
158antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.11888279
159regulation of interferon-alpha production (GO:0032647)2.11215566
160Golgi organization (GO:0007030)2.10691181
161protein export from nucleus (GO:0006611)2.10039204
162dosage compensation (GO:0007549)2.09147014
163positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.08871969
164positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.07063999
165negative regulation of interleukin-12 production (GO:0032695)2.06992149
166cell-substrate adherens junction assembly (GO:0007045)2.06572493
167focal adhesion assembly (GO:0048041)2.06572493
168Rap protein signal transduction (GO:0032486)2.05881911
169regulation of establishment of cell polarity (GO:2000114)2.05169219
170regulation of oxidative stress-induced neuron death (GO:1903203)2.04615131
171regulation of protein polyubiquitination (GO:1902914)2.04293306
172regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.03257317
173regulation of response to tumor cell (GO:0002834)2.03118276
174positive regulation of response to tumor cell (GO:0002836)2.03118276
175positive regulation of immune response to tumor cell (GO:0002839)2.03118276
176regulation of immune response to tumor cell (GO:0002837)2.03118276
177protein targeting to lysosome (GO:0006622)2.02783802
178establishment of protein localization to vacuole (GO:0072666)2.02783802
179protein targeting to vacuole (GO:0006623)2.02783802
180regulation of leukocyte degranulation (GO:0043300)2.02039024
181positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.01905636
182positive regulation of gamma-delta T cell activation (GO:0046645)1.99895244
183positive regulation of macroautophagy (GO:0016239)1.99612201

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.79611325
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.29650821
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.03789653
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.68043712
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.63182376
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.40585178
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.32172849
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.23989130
9CLOCK_20551151_ChIP-Seq_293T_Human3.18783894
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.15039846
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.88948611
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.81802533
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.67057511
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.57132593
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.40514373
16E2F7_22180533_ChIP-Seq_HELA_Human2.22215340
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.22069022
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.09113769
19AR_21909140_ChIP-Seq_LNCAP_Human2.03586819
20ZNF263_19887448_ChIP-Seq_K562_Human2.02460595
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.00096367
22GATA1_22025678_ChIP-Seq_K562_Human1.99718839
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.99057801
24SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.96732524
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.92761617
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.90493258
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.90183734
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.89752268
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.88061773
30SOX2_27498859_Chip-Seq_STOMACH_Mouse1.84466780
31SALL4_18804426_ChIP-ChIP_XEN_Mouse1.83057207
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79357794
33IRF8_27001747_Chip-Seq_BMDM_Mouse1.78105238
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72452200
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.66376515
36ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.63629306
37TFEB_21752829_ChIP-Seq_HELA_Human1.62553834
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.62117406
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60500720
40CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.59986039
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.59428937
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.57500624
43FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.56202801
44GATA6_25053715_ChIP-Seq_YYC3_Human1.56139791
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.55174059
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54854058
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.54217104
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.53863570
49FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.52568483
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.52564538
51P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52170451
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.50443616
53RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.50131142
54* ATF3_27146783_Chip-Seq_COLON_Human1.49211031
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.46106197
56SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.46106197
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.43255373
58CHD1_26751641_Chip-Seq_LNCaP_Human1.42882328
59BRD4_25478319_ChIP-Seq_HGPS_Human1.42060255
60STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40884010
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.39824768
62* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38246981
63MYC_22102868_ChIP-Seq_BL_Human1.38193412
64SPI1_23547873_ChIP-Seq_NB4_Human1.38130040
65FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.36299984
66MYB_26560356_Chip-Seq_TH1_Human1.35891490
67GATA4_25053715_ChIP-Seq_YYC3_Human1.35521033
68AHR_22903824_ChIP-Seq_MCF-7_Human1.35137270
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34849796
70FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33554044
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33546391
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.31140189
73MYB_26560356_Chip-Seq_TH2_Human1.30292212
74ELF5_23300383_ChIP-Seq_T47D_Human1.29096568
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28827785
76SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28500592
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27476041
78IRF8_21731497_ChIP-ChIP_J774_Mouse1.27133994
79NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27037277
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25868005
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23728015
82TCF7_22412390_ChIP-Seq_EML_Mouse1.23383578
83BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21777314
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18131298
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16544509
86* SOX2_20726797_ChIP-Seq_SW620_Human1.16520939
87UBF1/2_26484160_Chip-Seq_HMECs_Human1.16435363
88PU_27001747_Chip-Seq_BMDM_Mouse1.16134808
89ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15734218
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15591331
91FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.15101658
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14422156
93VDR_24763502_ChIP-Seq_THP-1_Human1.12439282
94AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10615576
95VDR_24787735_ChIP-Seq_THP-1_Human1.09848081
96ELK3_25401928_ChIP-Seq_HUVEC_Human1.09163436
97RUNX1_22412390_ChIP-Seq_EML_Mouse1.08972735
98RACK7_27058665_Chip-Seq_MCF-7_Human1.08881423
99* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08802720
100MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08416464
101SCL_19346495_ChIP-Seq_HPC-7_Human1.08202228
102STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06726103
103* CJUN_26792858_Chip-Seq_BT549_Human1.06366575
104IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06328807
105IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06297139
106EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06258125
107RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06242200
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06084190
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05748873
110WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04992000
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04987905
112SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04199133
113TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.03432780
114NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03130047
115RUNX_20019798_ChIP-Seq_JUKART_Human1.02460283
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02234042
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01438058
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00841996
119* HNF4A_19822575_ChIP-Seq_HepG2_Human1.00704248
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.00117087
121STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99853644
122PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99435330
123CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99066243
124PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97825959
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96660860
126SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96216741
127SPI1_23127762_ChIP-Seq_K562_Human0.95570670
128NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95431472
129GATA3_24758297_ChIP-Seq_MCF-7_Human0.95347097
130NCOR1_26117541_ChIP-Seq_K562_Human0.95291648
131RUNX1_27514584_Chip-Seq_MCF-7_Human0.94675924
132FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94549343
133STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94061202
134NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93212922
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93212922
136ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92968974
137TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91924636
138VDR_21846776_ChIP-Seq_THP-1_Human0.91505264
139TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90869632

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.12248758
2MP0002139_abnormal_hepatobiliary_system3.84279188
3MP0010234_abnormal_vibrissa_follicle3.83131076
4MP0005360_urolithiasis3.07726321
5MP0010352_gastrointestinal_tract_polyps2.99240280
6MP0003252_abnormal_bile_duct2.88528068
7MP0003300_gastrointestinal_ulcer2.77471727
8MP0005085_abnormal_gallbladder_physiolo2.68946051
9MP0005365_abnormal_bile_salt2.65866191
10MP0008438_abnormal_cutaneous_collagen2.62063879
11MP0002877_abnormal_melanocyte_morpholog2.59301933
12MP0008057_abnormal_DNA_replication2.40896506
13MP0002009_preneoplasia2.27740962
14MP0005451_abnormal_body_composition2.08781250
15MP0003566_abnormal_cell_adhesion2.06974983
16MP0004808_abnormal_hematopoietic_stem2.02224524
17MP0005076_abnormal_cell_differentiation1.92982487
18MP0001666_abnormal_nutrient_absorption1.81971795
19MP0006054_spinal_hemorrhage1.79224439
20MP0009053_abnormal_anal_canal1.78112830
21MP0002006_tumorigenesis1.75739980
22MP0005275_abnormal_skin_tensile1.75609427
23MP0001835_abnormal_antigen_presentation1.74300906
24MP0003763_abnormal_thymus_physiology1.72217437
25MP0008875_abnormal_xenobiotic_pharmacok1.70181527
26MP0004264_abnormal_extraembryonic_tissu1.68282616
27MP0002396_abnormal_hematopoietic_system1.67785094
28MP0010329_abnormal_lipoprotein_level1.60574451
29MP0009840_abnormal_foam_cell1.59781759
30MP0000537_abnormal_urethra_morphology1.55333517
31MP0003868_abnormal_feces_composition1.54940585
32MP0003191_abnormal_cellular_cholesterol1.53092681
33MP0005023_abnormal_wound_healing1.50541900
34MP0003828_pulmonary_edema1.49519453
35MP0005220_abnormal_exocrine_pancreas1.44019385
36MP0004272_abnormal_basement_membrane1.42335176
37MP0004185_abnormal_adipocyte_glucose1.41180427
38MP0005164_abnormal_response_to1.40888361
39MP0009384_cardiac_valve_regurgitation1.39846988
40MP0002896_abnormal_bone_mineralization1.39381467
41MP0010307_abnormal_tumor_latency1.37280082
42MP0003806_abnormal_nucleotide_metabolis1.36258807
43MP0005083_abnormal_biliary_tract1.34900997
44MP0002138_abnormal_hepatobiliary_system1.34286866
45MP0000465_gastrointestinal_hemorrhage1.33755016
46MP0003436_decreased_susceptibility_to1.33564575
47MP0003195_calcinosis1.31406692
48MP0004782_abnormal_surfactant_physiolog1.30179807
49MP0002060_abnormal_skin_morphology1.30169394
50MP0003656_abnormal_erythrocyte_physiolo1.28982846
51MP0003950_abnormal_plasma_membrane1.28935176
52MP0010678_abnormal_skin_adnexa1.28675177
53MP0000609_abnormal_liver_physiology1.26957083
54MP0005409_darkened_coat_color1.26325036
55MP0009697_abnormal_copulation1.26115756
56MP0000858_altered_metastatic_potential1.26040866
57MP0003091_abnormal_cell_migration1.25457671
58MP0003453_abnormal_keratinocyte_physiol1.25326870
59MP0005058_abnormal_lysosome_morphology1.21017224
60MP0001853_heart_inflammation1.20073585
61MP0004233_abnormal_muscle_weight1.18448883
62MP0001849_ear_inflammation1.18309509
63MP0004883_abnormal_blood_vessel1.16988014
64MP0000569_abnormal_digit_pigmentation1.16310967
65MP0002998_abnormal_bone_remodeling1.15811699
66MP0000627_abnormal_mammary_gland1.14977250
67MP0000685_abnormal_immune_system1.14429617
68MP0005464_abnormal_platelet_physiology1.11896798
69MP0002928_abnormal_bile_duct1.11573960
70MP0008007_abnormal_cellular_replicative1.10852749
71MP0003283_abnormal_digestive_organ1.10087406
72MP0001851_eye_inflammation1.09031320
73MP0002419_abnormal_innate_immunity1.08909221
74MP0001915_intracranial_hemorrhage1.08571352
75MP0005248_abnormal_Harderian_gland1.05891971
76MP0005621_abnormal_cell_physiology1.05842941
77MP0010155_abnormal_intestine_physiology1.05622211
78MP0003303_peritoneal_inflammation1.04451139
79MP0003183_abnormal_peptide_metabolism1.04421177
80MP0000733_abnormal_muscle_development1.03402623
81MP0008260_abnormal_autophagy1.03234634
82MP0004197_abnormal_fetal_growth/weight/1.03223892
83MP0000383_abnormal_hair_follicle1.01857339
84MP0005187_abnormal_penis_morphology1.00279278
85MP0000598_abnormal_liver_morphology0.99829749
86MP0002086_abnormal_extraembryonic_tissu0.99683086
87MP0005623_abnormal_meninges_morphology0.95504419
88MP0003045_fibrosis0.95110308
89MP0005000_abnormal_immune_tolerance0.94622314
90MP0002452_abnormal_antigen_presenting0.93977162
91MP0002254_reproductive_system_inflammat0.93390617
92MP0005501_abnormal_skin_physiology0.92733079
93MP0005332_abnormal_amino_acid0.90583218
94MP0009785_altered_susceptibility_to0.90472893
95MP0002398_abnormal_bone_marrow0.89992012
96MP0003448_altered_tumor_morphology0.89539354
97MP0003221_abnormal_cardiomyocyte_apopto0.89525164
98MP0002148_abnormal_hypersensitivity_rea0.88392078
99MP0009672_abnormal_birth_weight0.87904372
100MP0002118_abnormal_lipid_homeostasis0.87688117
101MP0005408_hypopigmentation0.87544107
102MP0009780_abnormal_chondrocyte_physiolo0.87287805
103MP0001800_abnormal_humoral_immune0.86650066
104MP0003123_paternal_imprinting0.86208961
105MP0008004_abnormal_stomach_pH0.85959410
106MP0002168_other_aberrant_phenotype0.85872296
107MP0001730_embryonic_growth_arrest0.85712073
108MP0003724_increased_susceptibility_to0.85550544
109MP0002092_abnormal_eye_morphology0.85519826
110MP0004381_abnormal_hair_follicle0.85442546
111MP0002405_respiratory_system_inflammati0.85322042
112MP0001873_stomach_inflammation0.85274721
113MP0005257_abnormal_intraocular_pressure0.84821976
114MP0002420_abnormal_adaptive_immunity0.84001133
115MP0005666_abnormal_adipose_tissue0.83911945
116MP0001819_abnormal_immune_cell0.83603598
117MP0003115_abnormal_respiratory_system0.83311825
118MP0010368_abnormal_lymphatic_system0.82276044
119MP0004957_abnormal_blastocyst_morpholog0.82110333
120MP0000427_abnormal_hair_cycle0.81382295
121MP0002723_abnormal_immune_serum0.80876961
122MP0009703_decreased_birth_body0.80300043
123MP0000377_abnormal_hair_follicle0.79876402
124MP0003279_aneurysm0.79493141
125MP0009643_abnormal_urine_homeostasis0.79481173
126MP0005025_abnormal_response_to0.79112547
127MP0004947_skin_inflammation0.78937256
128MP0001533_abnormal_skeleton_physiology0.78827666
129MP0001944_abnormal_pancreas_morphology0.78581152
130MP0002088_abnormal_embryonic_growth/wei0.78530656
131MP0002722_abnormal_immune_system0.78323080
132MP0000703_abnormal_thymus_morphology0.77922877
133MP0003943_abnormal_hepatobiliary_system0.77237224
134MP0003984_embryonic_growth_retardation0.77075833
135MP0002796_impaired_skin_barrier0.76339801
136MP0002084_abnormal_developmental_patter0.76306571
137MP0001845_abnormal_inflammatory_respons0.75116860
138MP0005384_cellular_phenotype0.74863159
139MP0003172_abnormal_lysosome_physiology0.74664431
140MP0002098_abnormal_vibrissa_morphology0.74422104
141MP0005380_embryogenesis_phenotype0.74315821
142MP0001672_abnormal_embryogenesis/_devel0.74315821
143MP0005397_hematopoietic_system_phenotyp0.73908798
144MP0001545_abnormal_hematopoietic_system0.73908798
145MP0000428_abnormal_craniofacial_morphol0.73842818
146MP0003077_abnormal_cell_cycle0.73812189
147MP0010094_abnormal_chromosome_stability0.73634737
148MP0005375_adipose_tissue_phenotype0.72593070
149MP0000003_abnormal_adipose_tissue0.72298636
150MP0000534_abnormal_ureter_morphology0.70988175
151MP0001243_abnormal_dermal_layer0.70929326
152MP0001216_abnormal_epidermal_layer0.70754015
153MP0000462_abnormal_digestive_system0.70033180
154MP0000767_abnormal_smooth_muscle0.69782862
155MP0003119_abnormal_digestive_system0.69123761
156MP0002166_altered_tumor_susceptibility0.68638898
157MP0005503_abnormal_tendon_morphology0.67519796
158MP0000350_abnormal_cell_proliferation0.66636522
159MP0001958_emphysema0.66475375
160MP0005319_abnormal_enzyme/_coenzyme0.66466388
161MP0003890_abnormal_embryonic-extraembry0.65981858
162MP0002115_abnormal_skeleton_extremities0.65922804
163MP0002697_abnormal_eye_size0.65859832

Predicted human phenotypes

RankGene SetZ-score
1Asymmetry of the thorax (HP:0001555)4.04625811
2Syringomyelia (HP:0003396)3.81582640
3Spinal cord lesions (HP:0100561)3.81582640
4Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.64594424
5Deep venous thrombosis (HP:0002625)3.53664949
6Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.43620664
7Cerebral aneurysm (HP:0004944)3.37688333
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.21597813
9Intrahepatic cholestasis (HP:0001406)3.20057696
10Subacute progressive viral hepatitis (HP:0006572)3.19224692
11Absent frontal sinuses (HP:0002688)3.10369334
12Protrusio acetabuli (HP:0003179)3.07844679
13Premature rupture of membranes (HP:0001788)3.03458804
14Xanthomatosis (HP:0000991)2.96939793
15Curly hair (HP:0002212)2.96902183
16Complement deficiency (HP:0004431)2.95794125
17Aortic aneurysm (HP:0004942)2.85009718
18Mitral valve prolapse (HP:0001634)2.77675865
19Abnormality of the frontal sinuses (HP:0002687)2.75598399
20Spastic diplegia (HP:0001264)2.75088524
21Cervical subluxation (HP:0003308)2.69844019
22Myocardial infarction (HP:0001658)2.66354385
23Abnormality of oral frenula (HP:0000190)2.66036816
24Papillary thyroid carcinoma (HP:0002895)2.61782651
25Shallow orbits (HP:0000586)2.55383470
26Epidermoid cyst (HP:0200040)2.54326287
27Ankle contracture (HP:0006466)2.48013005
28Abnormality of the common coagulation pathway (HP:0010990)2.47724066
29Acute myeloid leukemia (HP:0004808)2.46978887
30Osteolytic defects of the hand bones (HP:0009699)2.43581565
31Osteolytic defects of the phalanges of the hand (HP:0009771)2.43581565
32Insidious onset (HP:0003587)2.39007820
33Termporal pattern (HP:0011008)2.39007820
34Aortic dissection (HP:0002647)2.38887511
35Spondylolisthesis (HP:0003302)2.38676404
36Abnormality of the intrinsic pathway (HP:0010989)2.38642793
37Hepatocellular carcinoma (HP:0001402)2.38411483
38Hypobetalipoproteinemia (HP:0003563)2.35057627
39Abnormality of complement system (HP:0005339)2.34318778
40Flat acetabular roof (HP:0003180)2.32812887
41Aneurysm (HP:0002617)2.31155795
42Thoracic kyphosis (HP:0002942)2.29779424
43Deep philtrum (HP:0002002)2.21331805
44Thick nail (HP:0001805)2.17283962
45Abnormality of glutamine family amino acid metabolism (HP:0010902)2.16771718
46Atrophic scars (HP:0001075)2.16254446
47Abnormality of liposaccharide metabolism (HP:0010968)2.15255812
48Abnormality of glycosphingolipid metabolism (HP:0004343)2.15255812
49Abnormality of glycolipid metabolism (HP:0010969)2.15255812
50Viral hepatitis (HP:0006562)2.14548335
51Recurrent viral infections (HP:0004429)2.14008859
52Abnormality of aromatic amino acid family metabolism (HP:0004338)2.13771539
53Abnormality of the thoracic spine (HP:0100711)2.10320355
54Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.09490038
55Hand muscle atrophy (HP:0009130)2.08101964
56Dilatation of the ascending aorta (HP:0005111)2.07705323
57Short nail (HP:0001799)2.07387054
58Rectal prolapse (HP:0002035)2.06446494
59Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.06438176
60Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.06129775
61Enlarged penis (HP:0000040)2.05823526
62Back pain (HP:0003418)2.05689600
63Mucopolysacchariduria (HP:0008155)2.05412227
64Urinary glycosaminoglycan excretion (HP:0003541)2.05412227
65Hematochezia (HP:0002573)2.04867514
66Hypolipoproteinemia (HP:0010981)2.04783709
67Thin bony cortex (HP:0002753)2.03331245
68Lymphangioma (HP:0100764)2.03298106
69Thyroid carcinoma (HP:0002890)2.02697789
70Transitional cell carcinoma of the bladder (HP:0006740)2.02364593
71Abnormality of the lumbar spine (HP:0100712)2.02196947
72Cutaneous melanoma (HP:0012056)2.02182481
73Abnormal foot bone ossification (HP:0010675)2.01835127
74Resting tremor (HP:0002322)2.01746668
75Abnormality of the columella (HP:0009929)2.01688356
76Peritonitis (HP:0002586)2.01552620
77Abnormality of sulfur amino acid metabolism (HP:0004339)2.00601697
78Micronodular cirrhosis (HP:0001413)2.00592367
79Sparse lateral eyebrow (HP:0005338)2.00331338
80Aplasia cutis congenita (HP:0001057)2.00020324
81Hypoalphalipoproteinemia (HP:0003233)1.99888652
82Mitral stenosis (HP:0001718)1.99797553
83Systemic lupus erythematosus (HP:0002725)1.98128806
84Capillary hemangiomas (HP:0005306)1.96919895
85Ulnar bowing (HP:0003031)1.96102464
86Autoimmune hemolytic anemia (HP:0001890)1.96029205
87Bladder carcinoma (HP:0002862)1.95914769
88Bladder neoplasm (HP:0009725)1.95914769
89Arterial tortuosity (HP:0005116)1.95845199
90Esophageal varix (HP:0002040)1.95410961
91Abnormal cartilage morphology (HP:0002763)1.95245653
92Tetraparesis (HP:0002273)1.95115853
93Genu recurvatum (HP:0002816)1.95019766
94Increased mean platelet volume (HP:0011877)1.93291235
95Macroorchidism (HP:0000053)1.92550225
96Focal segmental glomerulosclerosis (HP:0000097)1.91607908
97Eczematoid dermatitis (HP:0000976)1.91595649
98T lymphocytopenia (HP:0005403)1.90754648
99Relative macrocephaly (HP:0004482)1.88676311
100Distal upper limb amyotrophy (HP:0007149)1.88541401
101Upper limb amyotrophy (HP:0009129)1.88541401
102Deviation of the thumb (HP:0009603)1.88441684
103Vascular tortuosity (HP:0004948)1.88009834
104Skin nodule (HP:0200036)1.85664720
105Right ventricular cardiomyopathy (HP:0011663)1.84359005
106Glomerulonephritis (HP:0000099)1.83786853
107Epiphyseal dysplasia (HP:0002656)1.81922053
108Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.81824718
109Hyperglycemia (HP:0003074)1.80992680
110Abnormality of macrophages (HP:0004311)1.80929153
111Protuberant abdomen (HP:0001538)1.80831389
112Germ cell neoplasia (HP:0100728)1.80425662
113Fat malabsorption (HP:0002630)1.80367659
114Colitis (HP:0002583)1.80327272
115Hypoglycemic coma (HP:0001325)1.79821042
116Retinal atrophy (HP:0001105)1.79217905
117Abnormality of the distal phalanges of the toes (HP:0010182)1.79080128
118Abnormality of polysaccharide metabolism (HP:0011012)1.79024565
119Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79024565
120Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79024565
121Abnormality of the Achilles tendon (HP:0005109)1.78819806
122Exostoses (HP:0100777)1.78014503
123Turricephaly (HP:0000262)1.77916829
124Hydroxyprolinuria (HP:0003080)1.76416654
125Abnormality of proline metabolism (HP:0010907)1.76416654
126Thickened calvaria (HP:0002684)1.76388636
127Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75618732
128Tibial bowing (HP:0002982)1.74986196
129Ankyloglossia (HP:0010296)1.74400332
130Broad face (HP:0000283)1.74175741
131Metaphyseal cupping (HP:0003021)1.73767339
132Striae distensae (HP:0001065)1.73307357
133Interstitial pulmonary disease (HP:0006530)1.72788945
134Glomerulosclerosis (HP:0000096)1.72762158
135Buphthalmos (HP:0000557)1.72242591
136Disproportionate tall stature (HP:0001519)1.70727233
137Radial bowing (HP:0002986)1.70703238
138Facial hemangioma (HP:0000329)1.69911384
139Thoracolumbar scoliosis (HP:0002944)1.69420808
140Hypoglycemic seizures (HP:0002173)1.69001855
141Blue sclerae (HP:0000592)1.68776697
142Fatigue (HP:0012378)1.68737667
143Delayed closure of the anterior fontanelle (HP:0001476)1.68686104
144Microglossia (HP:0000171)1.68229241
145Abnormality of T cell number (HP:0011839)1.67924725
146Recurrent abscess formation (HP:0002722)1.67666755
147Craniofacial hyperostosis (HP:0004493)1.67665913
148Biliary tract neoplasm (HP:0100574)1.67228541
149Increased density of long bones (HP:0006392)1.67201509
150Abnormality of nail color (HP:0100643)1.66721927
151Abnormality of the gastric mucosa (HP:0004295)1.66611713
152Cupped ribs (HP:0000887)1.66535234
153Camptodactyly of toe (HP:0001836)1.66082936
154Abdominal distention (HP:0003270)1.65627396
155Low anterior hairline (HP:0000294)1.64949519
156Dysostosis multiplex (HP:0000943)1.64682299
157Hallux valgus (HP:0001822)1.63988813
158Lower limb hyperreflexia (HP:0002395)1.63461518
159Renal cell carcinoma (HP:0005584)1.63366543
160Menstrual irregularities (HP:0000858)1.63191080
161Recurrent bacterial skin infections (HP:0005406)1.63041889
162Milia (HP:0001056)1.62921293
163Inflammation of the large intestine (HP:0002037)1.62859545
164Wormian bones (HP:0002645)1.62796123
165Periodontitis (HP:0000704)1.62477595
166Abnormality of the acetabulum (HP:0003170)1.62451544
167Malignant gastrointestinal tract tumors (HP:0006749)1.62384916
168Gastrointestinal carcinoma (HP:0002672)1.62384916
169Coarse hair (HP:0002208)1.62317351
170Increased CSF protein (HP:0002922)1.62039220
171Reduced antithrombin III activity (HP:0001976)1.61557401
172Alopecia of scalp (HP:0002293)1.60330355
173Loss of speech (HP:0002371)1.58942839
174Prominent nose (HP:0000448)1.58925137
175Osteomyelitis (HP:0002754)1.58350710
176Uterine leiomyosarcoma (HP:0002891)1.57605717
177Leiomyosarcoma (HP:0100243)1.57605717
178Heterotopia (HP:0002282)1.57497297
179Arterial thrombosis (HP:0004420)1.56656616
180Gastrointestinal inflammation (HP:0004386)1.56606759
181Bilateral sensorineural hearing impairment (HP:0008619)1.55342827
182B lymphocytopenia (HP:0010976)1.55285527
183Cellulitis (HP:0100658)1.55219816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.72793809
2LATS13.69606969
3TRIB33.40419690
4FRK2.94523293
5EIF2AK32.87179444
6IRAK32.71367403
7SCYL22.63760974
8PTK62.52860884
9ERN12.23622966
10EPHA22.20517679
11STK32.16346402
12PDGFRA2.08608391
13BMPR22.01536362
14EEF2K1.93940672
15PRPF4B1.90733101
16RIPK11.89447177
17SIK31.87331196
18CDK121.82039997
19DDR21.72684503
20MARK31.72291837
21CDK61.69588435
22MAP3K21.65932595
23MET1.62090368
24SIK11.61746448
25FLT31.61425302
26BRD41.61309492
27TGFBR21.59897301
28MAP3K101.58730832
29TTN1.56869484
30IRAK41.54983528
31MAP3K131.46944131
32CAMK1D1.44659919
33PTK21.43198884
34MST1R1.42178561
35PAK41.41070649
36FER1.39400108
37SMG11.36081982
38PAK21.33986150
39IRAK21.30051885
40LRRK21.29807090
41MTOR1.23082303
42STK101.22515950
43RET1.22451147
44RPS6KA41.21608411
45MAP3K31.20634099
46TAOK31.18625139
47FGFR41.17643851
48ZAP701.15830038
49PASK1.15609771
50MAP2K31.12579599
51NEK91.11381122
52PDGFRB1.11264497
53CAMK1G1.09304384
54EIF2AK11.07841905
55EPHA31.05752507
56ERBB41.05183057
57BMX1.04649548
58NUAK11.04173010
59ALK1.03436912
60FGFR11.03160638
61MST41.02571530
62MAP3K80.97228790
63MELK0.96351922
64YES10.95801583
65RPS6KB20.95263539
66BRSK20.94175413
67EPHB10.92892865
68NEK20.92774875
69NME20.91728441
70FGFR20.89768430
71ERBB30.89402723
72LATS20.88996653
73KSR10.86754555
74NEK60.85725249
75RPS6KB10.81628779
76SGK30.81159497
77IRAK10.81118809
78FGFR30.80486797
79JAK10.79831712
80KSR20.78225152
81MATK0.76972406
82CSK0.73173676
83STK390.72907601
84RIPK40.70747983
85PBK0.70041654
86ICK0.68053979
87JAK30.66601199
88CDC70.66547827
89MAP3K60.65824601
90CDK40.65652322
91AKT30.62839550
92CSNK1A1L0.62422209
93GSK3A0.61249041
94JAK20.60484886
95TAF10.60318136
96MAP3K120.59110223
97MOS0.58806198
98CSF1R0.58586745
99TTK0.55305727
100CDK90.53357159
101EGFR0.52635905
102PDPK10.52332587
103STK380.52277952
104TSSK60.51439351
105CDK70.51363847
106BCKDK0.50241731
107FGR0.50199478
108PAK30.50153811
109STK38L0.50107437
110TGFBR10.47694284
111ERBB20.47547399
112EIF2AK20.47382929
113BTK0.46703257
114MAP2K20.46030954
115PIK3CA0.45349240
116MAPK150.45194985
117NLK0.44780736
118HCK0.44647724
119CLK10.44557298
120PRKG20.44317751
121MAP2K10.44075482
122NEK10.43238105
123INSRR0.43170229
124INSR0.41861331
125DYRK1B0.41598335
126MAP3K50.39665261
127NTRK10.38311262
128HIPK20.37831897
129IGF1R0.37205273
130PIK3CG0.37167158
131TBK10.36999210
132CHUK0.36897298
133EPHB20.36563490
134ABL10.35272205
135MAP3K140.34710006
136MAP3K10.33605465
137CAMKK10.32806808
138MAP3K70.31772695
139TYK20.31153457
140STK240.30817412
141MAP3K90.30528508
142PIM10.30260916
143PRKD30.29645251
144TRPM70.29378984
145PLK30.29241878

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.88041636
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.71268665
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.43455734
4Selenocompound metabolism_Homo sapiens_hsa004502.17387672
5Complement and coagulation cascades_Homo sapiens_hsa046102.05936913
6Arginine biosynthesis_Homo sapiens_hsa002202.01120490
7Maturity onset diabetes of the young_Homo sapiens_hsa049501.86307065
8B cell receptor signaling pathway_Homo sapiens_hsa046621.84879274
9Other glycan degradation_Homo sapiens_hsa005111.77508474
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.70843686
11Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.66078237
12Pentose and glucuronate interconversions_Homo sapiens_hsa000401.57309010
13Tryptophan metabolism_Homo sapiens_hsa003801.56998447
14Sulfur metabolism_Homo sapiens_hsa009201.52503151
15Staphylococcus aureus infection_Homo sapiens_hsa051501.51569344
16Osteoclast differentiation_Homo sapiens_hsa043801.48253432
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46572914
18Hepatitis B_Homo sapiens_hsa051611.46238170
19Measles_Homo sapiens_hsa051621.41557234
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.41309595
21Lysine degradation_Homo sapiens_hsa003101.36408802
22Apoptosis_Homo sapiens_hsa042101.34034767
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33749231
24Bile secretion_Homo sapiens_hsa049761.32059369
25Adherens junction_Homo sapiens_hsa045201.31557592
26Hepatitis C_Homo sapiens_hsa051601.31412820
27ECM-receptor interaction_Homo sapiens_hsa045121.31342348
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.31157856
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30739690
30T cell receptor signaling pathway_Homo sapiens_hsa046601.26926915
31Fatty acid degradation_Homo sapiens_hsa000711.26412018
32Chronic myeloid leukemia_Homo sapiens_hsa052201.26374005
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.25397668
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24086840
35Influenza A_Homo sapiens_hsa051641.24029408
36Fat digestion and absorption_Homo sapiens_hsa049751.23387014
37Small cell lung cancer_Homo sapiens_hsa052221.21670458
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20770256
39Inositol phosphate metabolism_Homo sapiens_hsa005621.20628481
40Leishmaniasis_Homo sapiens_hsa051401.20573058
41One carbon pool by folate_Homo sapiens_hsa006701.20561925
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20470496
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19894888
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16260245
45Proteoglycans in cancer_Homo sapiens_hsa052051.13565796
46Sphingolipid signaling pathway_Homo sapiens_hsa040711.12963033
47Focal adhesion_Homo sapiens_hsa045101.11713488
48ErbB signaling pathway_Homo sapiens_hsa040121.11544798
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10690993
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10672035
51Sphingolipid metabolism_Homo sapiens_hsa006001.10667474
52Tuberculosis_Homo sapiens_hsa051521.10531463
53VEGF signaling pathway_Homo sapiens_hsa043701.10334998
54PPAR signaling pathway_Homo sapiens_hsa033201.10093328
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09665753
56Chemical carcinogenesis_Homo sapiens_hsa052041.09404438
57Bladder cancer_Homo sapiens_hsa052191.07968405
58Glycosaminoglycan degradation_Homo sapiens_hsa005311.06830168
59Shigellosis_Homo sapiens_hsa051311.05464056
60mTOR signaling pathway_Homo sapiens_hsa041501.04707865
61Caffeine metabolism_Homo sapiens_hsa002321.03453555
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02959609
63Herpes simplex infection_Homo sapiens_hsa051681.01966975
64Jak-STAT signaling pathway_Homo sapiens_hsa046301.00256182
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99904610
66Starch and sucrose metabolism_Homo sapiens_hsa005000.97320727
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97224876
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.95984281
69Amoebiasis_Homo sapiens_hsa051460.95119269
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94734270
71Insulin resistance_Homo sapiens_hsa049310.93256425
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92824990
73Prostate cancer_Homo sapiens_hsa052150.91594136
74Pancreatic cancer_Homo sapiens_hsa052120.91585973
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91214817
76ABC transporters_Homo sapiens_hsa020100.90260974
77MicroRNAs in cancer_Homo sapiens_hsa052060.90076102
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87199130
79Protein digestion and absorption_Homo sapiens_hsa049740.86750934
80Histidine metabolism_Homo sapiens_hsa003400.86262595
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85122600
82Endometrial cancer_Homo sapiens_hsa052130.83312578
83TGF-beta signaling pathway_Homo sapiens_hsa043500.82020686
84Lysosome_Homo sapiens_hsa041420.81950247
85Salmonella infection_Homo sapiens_hsa051320.81842036
86Melanoma_Homo sapiens_hsa052180.80726913
87Non-homologous end-joining_Homo sapiens_hsa034500.80234663
88Thyroid cancer_Homo sapiens_hsa052160.79226956
89Malaria_Homo sapiens_hsa051440.78645893
90Insulin signaling pathway_Homo sapiens_hsa049100.78633305
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.77845815
92Choline metabolism in cancer_Homo sapiens_hsa052310.77637017
93Butanoate metabolism_Homo sapiens_hsa006500.75934240
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75386365
95p53 signaling pathway_Homo sapiens_hsa041150.74771373
96Prion diseases_Homo sapiens_hsa050200.74648645
97Hippo signaling pathway_Homo sapiens_hsa043900.70591664
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69146647
99Fatty acid metabolism_Homo sapiens_hsa012120.69066310
100Toxoplasmosis_Homo sapiens_hsa051450.68926670
101Pertussis_Homo sapiens_hsa051330.68675313
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.68596923
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67483070
104Chemokine signaling pathway_Homo sapiens_hsa040620.67310109
105HIF-1 signaling pathway_Homo sapiens_hsa040660.66007253
106Biosynthesis of amino acids_Homo sapiens_hsa012300.64785572
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63057744
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.62496584
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62414551
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62284264
111Non-small cell lung cancer_Homo sapiens_hsa052230.61669772
112Dorso-ventral axis formation_Homo sapiens_hsa043200.60913774
113Glioma_Homo sapiens_hsa052140.60749647
114GnRH signaling pathway_Homo sapiens_hsa049120.60673285
115Retinol metabolism_Homo sapiens_hsa008300.60311334
116Phagosome_Homo sapiens_hsa041450.60297787
117mRNA surveillance pathway_Homo sapiens_hsa030150.60192401
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.59847203
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59820083
120Renal cell carcinoma_Homo sapiens_hsa052110.59169192
121Hematopoietic cell lineage_Homo sapiens_hsa046400.58746511
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.58585642
123Endocytosis_Homo sapiens_hsa041440.58583342
124HTLV-I infection_Homo sapiens_hsa051660.58388589
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58102187
126Colorectal cancer_Homo sapiens_hsa052100.57743834
127Circadian rhythm_Homo sapiens_hsa047100.56543862
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55690710
129Type II diabetes mellitus_Homo sapiens_hsa049300.55316356
130Phenylalanine metabolism_Homo sapiens_hsa003600.54603834
131AMPK signaling pathway_Homo sapiens_hsa041520.54483484
132Pathways in cancer_Homo sapiens_hsa052000.54240065
133beta-Alanine metabolism_Homo sapiens_hsa004100.53911809
134Steroid biosynthesis_Homo sapiens_hsa001000.53689917
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53030727
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52504987
137FoxO signaling pathway_Homo sapiens_hsa040680.50977407
138Peroxisome_Homo sapiens_hsa041460.50864390
139Viral carcinogenesis_Homo sapiens_hsa052030.50692687
140Antigen processing and presentation_Homo sapiens_hsa046120.50433017
141N-Glycan biosynthesis_Homo sapiens_hsa005100.49608554
142Legionellosis_Homo sapiens_hsa051340.48888616
143Gap junction_Homo sapiens_hsa045400.48668705
144Phospholipase D signaling pathway_Homo sapiens_hsa040720.47733512
145Platelet activation_Homo sapiens_hsa046110.46708357
146Vitamin digestion and absorption_Homo sapiens_hsa049770.46216363
147Thyroid hormone synthesis_Homo sapiens_hsa049180.45603819
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45161042
149Prolactin signaling pathway_Homo sapiens_hsa049170.44802468
150Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44339059
151Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43968922
152Cyanoamino acid metabolism_Homo sapiens_hsa004600.43858693
153Neurotrophin signaling pathway_Homo sapiens_hsa047220.43444137
154Acute myeloid leukemia_Homo sapiens_hsa052210.43167842
155Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43000555
156TNF signaling pathway_Homo sapiens_hsa046680.42119502
157Estrogen signaling pathway_Homo sapiens_hsa049150.41995354
158Tyrosine metabolism_Homo sapiens_hsa003500.41572112

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