FAM91A3P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K36 demethylation (GO:0070544)4.64832264
2cellular response to interleukin-15 (GO:0071350)4.53315759
3negative regulation of cell killing (GO:0031342)4.21189815
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.21189815
5response to interleukin-15 (GO:0070672)4.07147839
6fucose catabolic process (GO:0019317)3.95834636
7L-fucose metabolic process (GO:0042354)3.95834636
8L-fucose catabolic process (GO:0042355)3.95834636
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.88394614
10regulation of interleukin-12 biosynthetic process (GO:0045075)3.84045468
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.81874987
12positive regulation of gamma-delta T cell activation (GO:0046645)3.77695634
13negative regulation of interleukin-17 production (GO:0032700)3.69218808
14regulation of interleukin-6 biosynthetic process (GO:0045408)3.64230419
15negative T cell selection (GO:0043383)3.59186717
16regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.57022395
17regulation of oxidative stress-induced neuron death (GO:1903203)3.52250235
18antigen processing and presentation of endogenous antigen (GO:0019883)3.48932165
19rRNA catabolic process (GO:0016075)3.44507973
20regulation of gamma-delta T cell differentiation (GO:0045586)3.44197400
21regulation of B cell receptor signaling pathway (GO:0050855)3.41943154
22regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.35672163
23negative thymic T cell selection (GO:0045060)3.30443144
24negative regulation of defense response to virus (GO:0050687)3.24803790
25alpha-beta T cell differentiation involved in immune response (GO:0002293)3.22588124
26alpha-beta T cell activation involved in immune response (GO:0002287)3.22588124
27T cell differentiation involved in immune response (GO:0002292)3.22588124
28activated T cell proliferation (GO:0050798)3.21345032
29regulation of gamma-delta T cell activation (GO:0046643)3.17165594
30negative regulation by host of viral transcription (GO:0043922)3.10891030
31regulation of vitamin D biosynthetic process (GO:0060556)3.09225381
32negative regulation of neurological system process (GO:0031645)3.08319278
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.07122518
34regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.06957620
35positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.06957620
36regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.02106388
37TOR signaling (GO:0031929)3.01128602
38thymic T cell selection (GO:0045061)2.96365178
39alpha-beta T cell differentiation (GO:0046632)2.95001854
40macrophage activation (GO:0042116)2.92040335
41regulation of autophagic vacuole assembly (GO:2000785)2.90718769
42positive regulation of interleukin-1 beta secretion (GO:0050718)2.90183244
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.90109925
44negative regulation of metanephros development (GO:0072217)2.87730600
45negative regulation of smooth muscle cell proliferation (GO:0048662)2.87565337
46Peyers patch development (GO:0048541)2.86904055
47mucosal-associated lymphoid tissue development (GO:0048537)2.86904055
48coenzyme catabolic process (GO:0009109)2.86835549
49sulfation (GO:0051923)2.86227183
50regulation of phosphoprotein phosphatase activity (GO:0043666)2.85837615
51T cell selection (GO:0045058)2.85416586
52regulation of podosome assembly (GO:0071801)2.84093306
53regulation of interleukin-1 beta secretion (GO:0050706)2.83704081
54positive regulation of interleukin-1 secretion (GO:0050716)2.83113694
55defense response to protozoan (GO:0042832)2.82508229
56cellular extravasation (GO:0045123)2.82036912
57negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.79661902
58alpha-beta T cell activation (GO:0046631)2.77488454
59CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.77298895
60regulation of isotype switching to IgG isotypes (GO:0048302)2.77029987
61monoubiquitinated protein deubiquitination (GO:0035520)2.72637658
62positive regulation of tolerance induction (GO:0002645)2.72540943
63positive regulation by symbiont of host defense response (GO:0052509)2.71234420
64modulation by symbiont of host defense response (GO:0052031)2.71234420
65modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.71234420
66modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.71234420
67positive regulation by organism of defense response of other organism involved in symbiotic interact2.71234420
68modulation by symbiont of host immune response (GO:0052553)2.71234420
69positive T cell selection (GO:0043368)2.70178659
70microglial cell activation (GO:0001774)2.69047994
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.68346466
72mRNA cleavage (GO:0006379)2.68194732
73regulation of platelet aggregation (GO:0090330)2.67786734
74regulation of MHC class II biosynthetic process (GO:0045346)2.67383152
75adaptation of signaling pathway (GO:0023058)2.66491036
76regulation of interleukin-1 secretion (GO:0050704)2.65966624
77negative regulation of T cell apoptotic process (GO:0070233)2.65882904
78positive regulation of granulocyte differentiation (GO:0030854)2.63413155
79regulation of interferon-beta biosynthetic process (GO:0045357)2.62864127
80motile cilium assembly (GO:0044458)2.59990479
81positive regulation of catecholamine secretion (GO:0033605)2.59836971
82positive thymic T cell selection (GO:0045059)2.59763905
83cellular response to lithium ion (GO:0071285)2.56515226
84regulation of interleukin-17 production (GO:0032660)2.56422500
85CD4-positive, alpha-beta T cell activation (GO:0035710)2.55043423
86positive regulation of T cell mediated cytotoxicity (GO:0001916)2.50902413
87positive regulation of macrophage differentiation (GO:0045651)2.50105829
88response to protozoan (GO:0001562)2.49582562
89positive regulation of cell killing (GO:0031343)2.47732260
90regulation of cell killing (GO:0031341)2.47237024
91DNA deamination (GO:0045006)2.46489557
92macrophage activation involved in immune response (GO:0002281)2.45297709
93negative regulation of lymphocyte mediated immunity (GO:0002707)2.44150403
94lymph node development (GO:0048535)2.43692410
95regulation of necroptotic process (GO:0060544)2.43687584
96regulation of regulatory T cell differentiation (GO:0045589)2.42586231
97regulation of natural killer cell mediated immunity (GO:0002715)2.41557305
98regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.41557305
99response to pheromone (GO:0019236)2.41307948
100DNA double-strand break processing (GO:0000729)2.40905841

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.67532400
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.91154319
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.30973147
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.82775690
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.74410691
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.02617537
7MYB_26560356_Chip-Seq_TH2_Human2.86349308
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.80173759
9IGF1R_20145208_ChIP-Seq_DFB_Human2.72462955
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.49912214
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29838299
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28047749
13MYB_26560356_Chip-Seq_TH1_Human2.20387287
14RUNX_20019798_ChIP-Seq_JUKART_Human2.16923623
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.16522409
16SPI1_23547873_ChIP-Seq_NB4_Human2.05823701
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.05741506
18GATA3_27048872_Chip-Seq_THYMUS_Human2.03530444
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.99813425
20GATA3_26560356_Chip-Seq_TH2_Human1.88723365
21STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80893827
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.79019145
23ER_23166858_ChIP-Seq_MCF-7_Human1.73865313
24IRF8_27001747_Chip-Seq_BMDM_Mouse1.71350302
25VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.61759412
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58881617
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58123370
28VDR_24787735_ChIP-Seq_THP-1_Human1.49202143
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44529619
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44216846
31VDR_23849224_ChIP-Seq_CD4+_Human1.41866957
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41496794
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.37746687
34SCL_19346495_ChIP-Seq_HPC-7_Human1.37363461
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34931967
36MAF_26560356_Chip-Seq_TH2_Human1.33407730
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.32759677
38FOXP3_21729870_ChIP-Seq_TREG_Human1.32348202
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29754001
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29742491
41MAF_26560356_Chip-Seq_TH1_Human1.29204215
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25015115
43ZNF274_21170338_ChIP-Seq_K562_Hela1.24776428
44UTX_26944678_Chip-Seq_JUKART_Human1.24598027
45GATA1_22025678_ChIP-Seq_K562_Human1.24533133
46VDR_22108803_ChIP-Seq_LS180_Human1.23193970
47VDR_24763502_ChIP-Seq_THP-1_Human1.22194677
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21707345
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.17392632
50GBX2_23144817_ChIP-Seq_PC3_Human1.16102266
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14370982
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06498914
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06330159
54E2F7_22180533_ChIP-Seq_HELA_Human1.06099007
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04832111
56RXR_22108803_ChIP-Seq_LS180_Human1.04132118
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03285793
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03000184
59PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02601342
60SPI1_20517297_ChIP-Seq_HL60_Human1.01527906
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98901402
62CBP_20019798_ChIP-Seq_JUKART_Human0.98901402
63CIITA_25753668_ChIP-Seq_RAJI_Human0.97919051
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96122295
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95836752
66SPI1_23127762_ChIP-Seq_K562_Human0.95833988
67GATA3_26560356_Chip-Seq_TH1_Human0.94478548
68EWS_26573619_Chip-Seq_HEK293_Human0.90865888
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88182629
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88143067
71NANOG_20526341_ChIP-Seq_ESCs_Human0.87925444
72P300_19829295_ChIP-Seq_ESCs_Human0.87883720
73GATA2_21666600_ChIP-Seq_HMVEC_Human0.87455962
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86518128
75ELK1_19687146_ChIP-ChIP_HELA_Human0.85360968
76ELF5_23300383_ChIP-Seq_T47D_Human0.84752648
77RUNX1_22412390_ChIP-Seq_EML_Mouse0.84008926
78CDX2_22108803_ChIP-Seq_LS180_Human0.82724978
79HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82254777
80PRDM14_20953172_ChIP-Seq_ESCs_Human0.82115939
81BCAT_22108803_ChIP-Seq_LS180_Human0.81423595
82DCP1A_22483619_ChIP-Seq_HELA_Human0.80148791
83FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79889923
84STAT1_20625510_ChIP-Seq_HELA_Human0.78045660
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78041555
86GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.76361087
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.75879365
88RAC3_21632823_ChIP-Seq_H3396_Human0.75871925
89AR_21572438_ChIP-Seq_LNCaP_Human0.75818976
90TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.74766857
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.72591304
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.72488783
93FOXM1_23109430_ChIP-Seq_U2OS_Human0.72352881
94MYC_22102868_ChIP-Seq_BL_Human0.72025871
95E2F4_17652178_ChIP-ChIP_JURKAT_Human0.70178022
96SMRT_27268052_Chip-Seq_Bcells_Human0.70057497
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.69957601
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68954037
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.68954037
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.68423955

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.58011736
2MP0003763_abnormal_thymus_physiology3.55058034
3MP0005671_abnormal_response_to3.11318125
4MP0008057_abnormal_DNA_replication3.06076415
5MP0003724_increased_susceptibility_to3.05814356
6MP0000465_gastrointestinal_hemorrhage2.62988901
7MP0001800_abnormal_humoral_immune2.47409374
8MP0003806_abnormal_nucleotide_metabolis2.44688941
9MP0000685_abnormal_immune_system2.40255734
10MP0005000_abnormal_immune_tolerance2.35552800
11MP0001873_stomach_inflammation2.32445192
12MP0003436_decreased_susceptibility_to2.31099908
13MP0009785_altered_susceptibility_to2.26208787
14MP0009697_abnormal_copulation2.21102803
15MP0002132_abnormal_respiratory_system2.16974359
16MP0002148_abnormal_hypersensitivity_rea2.12571068
17MP0002163_abnormal_gland_morphology2.12419250
18MP0002420_abnormal_adaptive_immunity2.12313924
19MP0001819_abnormal_immune_cell2.10820850
20MP0004381_abnormal_hair_follicle2.09974233
21MP0002405_respiratory_system_inflammati2.08164783
22MP0002723_abnormal_immune_serum2.05045199
23MP0004782_abnormal_surfactant_physiolog2.03145983
24MP0002138_abnormal_hepatobiliary_system2.01488774
25MP0005387_immune_system_phenotype1.99513070
26MP0001790_abnormal_immune_system1.99513070
27MP0009333_abnormal_splenocyte_physiolog1.98369866
28MP0002452_abnormal_antigen_presenting1.93353947
29MP0002009_preneoplasia1.87362552
30MP0002419_abnormal_innate_immunity1.82950036
31MP0000703_abnormal_thymus_morphology1.79900208
32MP0004084_abnormal_cardiac_muscle1.77781322
33MP0002166_altered_tumor_susceptibility1.77774711
34MP0002722_abnormal_immune_system1.76123656
35MP0002396_abnormal_hematopoietic_system1.72956468
36MP0008004_abnormal_stomach_pH1.71884422
37MP0002398_abnormal_bone_marrow1.70315376
38MP0010155_abnormal_intestine_physiology1.62868376
39MP0000716_abnormal_immune_system1.61120082
40MP0003828_pulmonary_edema1.60801646
41MP0010368_abnormal_lymphatic_system1.60046042
42MP0005025_abnormal_response_to1.59850473
43MP0000689_abnormal_spleen_morphology1.57711495
44MP0008007_abnormal_cellular_replicative1.53591198
45MP0003866_abnormal_defecation1.51102761
46MP0003315_abnormal_perineum_morphology1.43603776
47MP0001661_extended_life_span1.40916012
48MP0003693_abnormal_embryo_hatching1.36553790
49MP0006082_CNS_inflammation1.35532902
50MP0005075_abnormal_melanosome_morpholog1.33915352
51MP0003195_calcinosis1.28952942
52MP0002429_abnormal_blood_cell1.28499022
53MP0004264_abnormal_extraembryonic_tissu1.26585150
54MP0002102_abnormal_ear_morphology1.25940324
55MP0010094_abnormal_chromosome_stability1.23360907
56MP0001845_abnormal_inflammatory_respons1.21721344
57MP0003646_muscle_fatigue1.18043259
58MP0003868_abnormal_feces_composition1.14865927
59MP0010307_abnormal_tumor_latency1.13478404
60MP0002006_tumorigenesis1.11519007
61MP0002277_abnormal_respiratory_mucosa1.10135582
62MP0004883_abnormal_blood_vessel1.07993315
63MP0002693_abnormal_pancreas_physiology1.05845467
64MP0003172_abnormal_lysosome_physiology1.05515011
65MP0001919_abnormal_reproductive_system0.99492271
66MP0004036_abnormal_muscle_relaxation0.96927116
67MP0003300_gastrointestinal_ulcer0.96598158
68MP0005164_abnormal_response_to0.96092074
69MP0005647_abnormal_sex_gland0.94681755
70MP0001664_abnormal_digestion0.91661287
71MP0005410_abnormal_fertilization0.91568226
72MP0009764_decreased_sensitivity_to0.91177914
73MP0000537_abnormal_urethra_morphology0.90321568
74MP0002998_abnormal_bone_remodeling0.89699852
75MP0000749_muscle_degeneration0.88552977
76MP0008058_abnormal_DNA_repair0.88172268
77MP0001533_abnormal_skeleton_physiology0.86979693
78MP0003656_abnormal_erythrocyte_physiolo0.82628468
79MP0005389_reproductive_system_phenotype0.82582483
80MP0001853_heart_inflammation0.81932482
81MP0002127_abnormal_cardiovascular_syste0.81254895
82MP0002019_abnormal_tumor_incidence0.80354807
83MP0008469_abnormal_protein_level0.80191026
84MP0005166_decreased_susceptibility_to0.78688094
85MP0002160_abnormal_reproductive_system0.77610605
86MP0005464_abnormal_platelet_physiology0.77549003
87MP0005379_endocrine/exocrine_gland_phen0.77143927
88MP0004808_abnormal_hematopoietic_stem0.75184216
89MP0006035_abnormal_mitochondrial_morpho0.72717461
90MP0004957_abnormal_blastocyst_morpholog0.72673295
91MP0003303_peritoneal_inflammation0.72410649
92MP0001849_ear_inflammation0.70524694
93MP0000470_abnormal_stomach_morphology0.65228479
94MP0006072_abnormal_retinal_apoptosis0.61968665
95MP0001929_abnormal_gametogenesis0.61653329
96MP0005376_homeostasis/metabolism_phenot0.60000879
97MP0001958_emphysema0.59174994
98MP0000490_abnormal_crypts_of0.58498643
99MP0008873_increased_physiological_sensi0.57404739
100MP0000249_abnormal_blood_vessel0.57212237

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the columella (HP:0009929)5.14160772
2Abnormality of T cell number (HP:0011839)4.52693181
3T lymphocytopenia (HP:0005403)4.36864969
4Reduced antithrombin III activity (HP:0001976)4.32942908
5Eosinophilia (HP:0001880)4.06258866
6Abnormality of eosinophils (HP:0001879)3.70734714
7Abnormal delayed hypersensitivity skin test (HP:0002963)3.61764753
8Abnormality of T cells (HP:0002843)3.60500682
9Granulocytopenia (HP:0001913)3.53938269
10Asymmetry of the thorax (HP:0001555)3.38075831
11Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.38062230
12Recurrent fungal infections (HP:0002841)3.35115870
13Abnormality of the lumbar spine (HP:0100712)3.33846684
14Thoracic kyphosis (HP:0002942)3.31026042
15Stomatitis (HP:0010280)3.22946585
16Resting tremor (HP:0002322)3.21435278
17Abnormality of T cell physiology (HP:0011840)3.11655974
18IgG deficiency (HP:0004315)3.11231427
19Gastrointestinal infarctions (HP:0005244)3.09147709
20Fibular aplasia (HP:0002990)3.06550326
21Pustule (HP:0200039)2.98542304
22Autoimmune hemolytic anemia (HP:0001890)2.95909810
23Recurrent cutaneous fungal infections (HP:0011370)2.92073749
24Chronic mucocutaneous candidiasis (HP:0002728)2.92073749
25Hematochezia (HP:0002573)2.87686851
26Recurrent viral infections (HP:0004429)2.79827668
27Hemoptysis (HP:0002105)2.75634315
28Alveolar cell carcinoma (HP:0006519)2.70966993
29Leukocytosis (HP:0001974)2.70349314
30Colitis (HP:0002583)2.67906581
31Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.64225585
32Carpal bone hypoplasia (HP:0001498)2.61879798
33Autoimmune thrombocytopenia (HP:0001973)2.59588345
34Neoplasm of the tracheobronchial system (HP:0100552)2.57924353
35Spontaneous hematomas (HP:0007420)2.57806976
36Abnormality of DNA repair (HP:0003254)2.53971546
37Abnormality of B cell number (HP:0010975)2.52498452
38Retrobulbar optic neuritis (HP:0100654)2.51782226
39Optic neuritis (HP:0100653)2.51782226
40Hypoproteinemia (HP:0003075)2.50321003
41Chronic diarrhea (HP:0002028)2.49897954
42Abnormal protein glycosylation (HP:0012346)2.49362471
43Abnormal glycosylation (HP:0012345)2.49362471
44Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.49362471
45Abnormal protein N-linked glycosylation (HP:0012347)2.49362471
46Myositis (HP:0100614)2.44707113
47Chest pain (HP:0100749)2.42812251
48Clumsiness (HP:0002312)2.40270889
49Inflammation of the large intestine (HP:0002037)2.36541036
50B lymphocytopenia (HP:0010976)2.35352960
51Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.33385884
52Panhypogammaglobulinemia (HP:0003139)2.33188411
53IgA deficiency (HP:0002720)2.32854491
54Broad ribs (HP:0000885)2.31540789
55Orchitis (HP:0100796)2.28006061
56Aortic aneurysm (HP:0004942)2.27211344
57Recurrent bacterial skin infections (HP:0005406)2.25431407
58Increased IgM level (HP:0003496)2.25407582
59Severe combined immunodeficiency (HP:0004430)2.24635865
60Vasculitis (HP:0002633)2.23484463
61Meningitis (HP:0001287)2.22222618
62Hypoplasia of the pons (HP:0012110)2.18626420
63Abnormality of the frontal sinuses (HP:0002687)2.17300418
64Gastrointestinal inflammation (HP:0004386)2.17012484
65Abnormality of the pons (HP:0007361)2.15187407
66Increased neuronal autofluorescent lipopigment (HP:0002074)2.13618321
67Arterial thrombosis (HP:0004420)2.10066619
68Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09416339
69Eczematoid dermatitis (HP:0000976)2.07120126
70Abnormality of the prostate (HP:0008775)2.03131399
71Pulmonary infiltrates (HP:0002113)2.00949700
72Mediastinal lymphadenopathy (HP:0100721)2.00579928
73IgM deficiency (HP:0002850)1.99733419
74Recurrent bronchitis (HP:0002837)1.97620935
75Recurrent abscess formation (HP:0002722)1.95065156
76Pulmonary embolism (HP:0002204)1.93804643
77Dynein arm defect of respiratory motile cilia (HP:0012255)1.88447963
78Absent/shortened dynein arms (HP:0200106)1.88447963
79Hypothermia (HP:0002045)1.86881759
80Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86430544
81Muscular dystrophy (HP:0003560)1.85723614
82Type I transferrin isoform profile (HP:0003642)1.85089157
83Anorexia (HP:0002039)1.84721603
84Facial diplegia (HP:0001349)1.84686825
85Acute lymphatic leukemia (HP:0006721)1.83797391
86Chronic sinusitis (HP:0011109)1.83364609
87Thoracolumbar scoliosis (HP:0002944)1.83205363
88Stomach cancer (HP:0012126)1.82447874
89Recurrent skin infections (HP:0001581)1.82362639
90Thyroiditis (HP:0100646)1.82319213
91Abnormality of the thoracic spine (HP:0100711)1.82049327
92Gangrene (HP:0100758)1.80421978
93Keratoconjunctivitis sicca (HP:0001097)1.78612260
94Obstructive lung disease (HP:0006536)1.78134798
95Chronic obstructive pulmonary disease (HP:0006510)1.78134798
96Abnormal rod and cone electroretinograms (HP:0008323)1.77897144
97Neutropenia (HP:0001875)1.77114991
98Absent thumb (HP:0009777)1.72612682
99Combined immunodeficiency (HP:0005387)1.72604367
100Abnormality of oral frenula (HP:0000190)1.70709054

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK14.61678248
2TXK3.63543016
3MARK33.51626344
4EIF2AK32.93620414
5MAP4K12.66694362
6LATS12.52852244
7TIE12.30075433
8NEK22.03150255
9IRAK22.02243592
10FRK1.91973234
11ZAK1.89782850
12MAP3K131.78198217
13EIF2AK11.77685424
14GRK61.72743159
15BMPR21.65641582
16BTK1.63263401
17ZAP701.57008899
18TLK11.54810907
19ITK1.54499945
20NLK1.54249956
21RIPK41.53950268
22IRAK41.52268657
23BMPR1B1.42260893
24MAP3K141.41930043
25MYLK1.37415625
26SCYL21.37389682
27PRKCQ1.36486269
28TEC1.35850240
29FES1.35174101
30MUSK1.21987659
31ACVR1B1.14781022
32MAP3K21.14321632
33CDK31.14100648
34MELK1.10866329
35MAP2K71.10645987
36CAMKK21.09274298
37IKBKE1.08401048
38HCK1.04072353
39BLK1.03456722
40CLK11.03191059
41EEF2K1.02954397
42TSSK61.01765011
43RPS6KB10.99885836
44BUB10.99485425
45IRAK10.98535983
46RPS6KA40.96734309
47MAP3K10.94442702
48CSK0.93413649
49OBSCN0.92418313
50KIT0.91817702
51OXSR10.90028136
52STK38L0.85540488
53STK390.85165049
54TRIM280.84813807
55LRRK20.84709768
56PRKG20.83515277
57SYK0.82816325
58STK100.81531977
59GRK10.80253342
60BRSK20.79849346
61GRK50.79754195
62TNK20.77943834
63CSNK1A1L0.77874450
64PKN20.77869434
65JAK30.75504910
66RPS6KA50.75304476
67VRK10.74467776
68NUAK10.72850771
69KDR0.72520400
70TGFBR20.70418207
71LCK0.68892053
72PASK0.68861559
73JAK10.68204176
74FGR0.67916140
75MAP3K70.67194515
76STK160.66013908
77TAOK30.66002883
78MAPKAPK30.61450478
79MAPKAPK20.61003768
80MOS0.59925929
81IKBKB0.59617663
82MST40.59015552
83SRPK10.58945176
84WEE10.58354322
85MKNK20.57529549
86FLT30.57030727
87JAK20.56132522
88PLK30.56103901
89MAP3K50.50054973
90TRPM70.49809626
91STK380.47113410
92ADRBK20.47052124
93TAF10.46705186
94ERBB40.46414517
95EGFR0.45992447
96CAMKK10.44765360
97RET0.43792168
98TGFBR10.43614405
99MAPK150.43080627
100MAPK120.41653680

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053322.89578629
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.71309839
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.58558238
4T cell receptor signaling pathway_Homo sapiens_hsa046602.53883571
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.46709442
6Primary immunodeficiency_Homo sapiens_hsa053402.34987571
7Allograft rejection_Homo sapiens_hsa053302.26970708
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.21394052
9NOD-like receptor signaling pathway_Homo sapiens_hsa046211.82704775
10Measles_Homo sapiens_hsa051621.80511930
11Antigen processing and presentation_Homo sapiens_hsa046121.78529800
12B cell receptor signaling pathway_Homo sapiens_hsa046621.72891741
13Regulation of autophagy_Homo sapiens_hsa041401.71432803
14Leishmaniasis_Homo sapiens_hsa051401.71279059
15Apoptosis_Homo sapiens_hsa042101.68251658
16Autoimmune thyroid disease_Homo sapiens_hsa053201.68004054
17Hematopoietic cell lineage_Homo sapiens_hsa046401.64199113
18Osteoclast differentiation_Homo sapiens_hsa043801.63892235
19Herpes simplex infection_Homo sapiens_hsa051681.59616430
20Type I diabetes mellitus_Homo sapiens_hsa049401.56419767
21TNF signaling pathway_Homo sapiens_hsa046681.53822186
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51963196
23Olfactory transduction_Homo sapiens_hsa047401.49956243
24Legionellosis_Homo sapiens_hsa051341.46801993
25Malaria_Homo sapiens_hsa051441.43792863
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39467769
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38541379
28Proteasome_Homo sapiens_hsa030501.37804309
29Rheumatoid arthritis_Homo sapiens_hsa053231.35993776
30Non-homologous end-joining_Homo sapiens_hsa034501.27346769
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27256184
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.23815534
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.22833063
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20803535
35Tuberculosis_Homo sapiens_hsa051521.11369275
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08590461
37Nitrogen metabolism_Homo sapiens_hsa009101.05509347
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03915102
39Influenza A_Homo sapiens_hsa051641.01002088
40Acute myeloid leukemia_Homo sapiens_hsa052210.97159492
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96344147
42RNA degradation_Homo sapiens_hsa030180.96100237
43Hepatitis B_Homo sapiens_hsa051610.94538309
44Mismatch repair_Homo sapiens_hsa034300.93673219
45Circadian rhythm_Homo sapiens_hsa047100.92388193
46Basal transcription factors_Homo sapiens_hsa030220.91279026
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90504186
48Dorso-ventral axis formation_Homo sapiens_hsa043200.90460715
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89888922
50TGF-beta signaling pathway_Homo sapiens_hsa043500.89310011
51DNA replication_Homo sapiens_hsa030300.88016616
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87521712
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80745003
54HTLV-I infection_Homo sapiens_hsa051660.79977088
55Toxoplasmosis_Homo sapiens_hsa051450.79669625
56African trypanosomiasis_Homo sapiens_hsa051430.77757377
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75617772
58p53 signaling pathway_Homo sapiens_hsa041150.73381032
59FoxO signaling pathway_Homo sapiens_hsa040680.72433178
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67770067
61Salmonella infection_Homo sapiens_hsa051320.67250648
62Viral myocarditis_Homo sapiens_hsa054160.67104610
63Platelet activation_Homo sapiens_hsa046110.66290644
64Systemic lupus erythematosus_Homo sapiens_hsa053220.66290348
65Nucleotide excision repair_Homo sapiens_hsa034200.65336458
66Butanoate metabolism_Homo sapiens_hsa006500.64718001
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64590403
68mTOR signaling pathway_Homo sapiens_hsa041500.62993420
69Asthma_Homo sapiens_hsa053100.62841538
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.61593695
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61140097
72Chemokine signaling pathway_Homo sapiens_hsa040620.61051174
73Staphylococcus aureus infection_Homo sapiens_hsa051500.61028974
74Renin secretion_Homo sapiens_hsa049240.58883158
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58798702
76Epstein-Barr virus infection_Homo sapiens_hsa051690.56755349
77Thyroid cancer_Homo sapiens_hsa052160.56623205
78One carbon pool by folate_Homo sapiens_hsa006700.56547098
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.55641147
80Selenocompound metabolism_Homo sapiens_hsa004500.55277065
81Viral carcinogenesis_Homo sapiens_hsa052030.53912840
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53217906
83Non-small cell lung cancer_Homo sapiens_hsa052230.52514891
84Oxytocin signaling pathway_Homo sapiens_hsa049210.51612569
85RNA transport_Homo sapiens_hsa030130.51096904
86Gap junction_Homo sapiens_hsa045400.51002828
87HIF-1 signaling pathway_Homo sapiens_hsa040660.50566310
88Prostate cancer_Homo sapiens_hsa052150.48733585
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43811718
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.42753302
91Estrogen signaling pathway_Homo sapiens_hsa049150.42280243
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40930135
93Fanconi anemia pathway_Homo sapiens_hsa034600.39993381
94Hepatitis C_Homo sapiens_hsa051600.39485533
95Phagosome_Homo sapiens_hsa041450.38226812
96MAPK signaling pathway_Homo sapiens_hsa040100.37359761
97Hedgehog signaling pathway_Homo sapiens_hsa043400.37233381
98Salivary secretion_Homo sapiens_hsa049700.35617939
99Sphingolipid metabolism_Homo sapiens_hsa006000.34836639
100Taste transduction_Homo sapiens_hsa047420.33916805

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