ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	7.43058553
2	interleukin-1-mediated signaling pathway (GO:0070498)	7.06905434
3	positive regulation of prostaglandin secretion (GO:0032308)	6.45822399
4	positive regulation of heat generation (GO:0031652)	6.12560681
5	regulation of fever generation (GO:0031620)	5.53515975
6	otic vesicle formation (GO:0030916)	5.52296298
7	regulation of prostaglandin secretion (GO:0032306)	5.28869679
8	regulation of heat generation (GO:0031650)	5.12974428
9	serotonin receptor signaling pathway (GO:0007210)	4.89141959
10	platelet dense granule organization (GO:0060155)	4.88303875
11	positive regulation of dendritic spine morphogenesis (GO:0061003)	4.85459901
12	neurofilament cytoskeleton organization (GO:0060052)	4.50195691
13	positive regulation of osteoclast differentiation (GO:0045672)	4.43725875
14	sequestering of actin monomers (GO:0042989)	4.42672360
15	regulation of phospholipid biosynthetic process (GO:0071071)	4.35558234
16	axoneme assembly (GO:0035082)	4.25072080
17	positive regulation of icosanoid secretion (GO:0032305)	4.23552355
18	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.10875057
19	sulfation (GO:0051923)	4.10285014
20	regulation of interleukin-12 biosynthetic process (GO:0045075)	4.09921319
21	presynaptic membrane organization (GO:0097090)	3.96549759
22	synaptic transmission, cholinergic (GO:0007271)	3.95652504
23	protein-cofactor linkage (GO:0018065)	3.95304048
24	positive regulation of fatty acid transport (GO:2000193)	3.89854264
25	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.79211368
26	regulation of mitotic spindle checkpoint (GO:1903504)	3.79211368
27	auditory behavior (GO:0031223)	3.79187471
28	regulation of immunoglobulin secretion (GO:0051023)	3.73800012
29	anterograde synaptic vesicle transport (GO:0048490)	3.68486413
30	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-	3.62547463
31	regulation of appetite (GO:0032098)	3.60649260
32	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.54456039
33	amyloid precursor protein catabolic process (GO:0042987)	3.36917893
34	lateral sprouting from an epithelium (GO:0060601)	3.34340870
35	response to lipoprotein particle (GO:0055094)	3.34200102
36	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.32404706
37	positive regulation of T cell cytokine production (GO:0002726)	3.32219762
38	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.31568415
39	short-term memory (GO:0007614)	3.30872838
40	regulation of action potential (GO:0098900)	3.28994040
41	histone H4-K12 acetylation (GO:0043983)	3.26683467
42	protein polyglutamylation (GO:0018095)	3.24358700
43	reflex (GO:0060004)	3.24136252
44	bone resorption (GO:0045453)	3.22845217
45	multicellular organism reproduction (GO:0032504)	3.20540709
46	pyrimidine nucleobase catabolic process (GO:0006208)	3.19435074
47	ATP synthesis coupled proton transport (GO:0015986)	3.17823308
48	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.17823308
49	positive regulation of transcription regulatory region DNA binding (GO:2000679)	3.16409103
50	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.15413966
51	presynaptic membrane assembly (GO:0097105)	3.14685724
52	postsynaptic membrane organization (GO:0001941)	3.12265337
53	neuron fate determination (GO:0048664)	3.08406501
54	regulation of glucokinase activity (GO:0033131)	3.08387698
55	regulation of hexokinase activity (GO:1903299)	3.08387698
56	anterograde axon cargo transport (GO:0008089)	3.01943858
57	phospholipid homeostasis (GO:0055091)	3.00557417
58	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.98881620
59	limb bud formation (GO:0060174)	2.98807088
60	axonal fasciculation (GO:0007413)	2.95455595
61	regulation of icosanoid secretion (GO:0032303)	2.89853144
62	regulation of dopamine secretion (GO:0014059)	2.88600904
63	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.87356053
64	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.87356053
65	NADH dehydrogenase complex assembly (GO:0010257)	2.87356053
66	response to auditory stimulus (GO:0010996)	2.87355401
67	mechanosensory behavior (GO:0007638)	2.86990474
68	positive regulation of organic acid transport (GO:0032892)	2.86743609
69	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.85474495
70	regulation of male gonad development (GO:2000018)	2.81120800
71	glutamine family amino acid biosynthetic process (GO:0009084)	2.78763523
72	electron transport chain (GO:0022900)	2.78672890
73	regulation of dendritic spine morphogenesis (GO:0061001)	2.77802557
74	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.77059551
75	behavioral fear response (GO:0001662)	2.74892315
76	behavioral defense response (GO:0002209)	2.74892315
77	monocyte chemotaxis (GO:0002548)	2.74577595
78	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.73815630
79	nucleobase catabolic process (GO:0046113)	2.73495882
80	positive regulation of bone remodeling (GO:0046852)	2.73305223
81	positive regulation of bone resorption (GO:0045780)	2.73305223
82	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.73250765
83	forebrain morphogenesis (GO:0048853)	2.72834110
84	synapse assembly (GO:0007416)	2.72412182
85	retinal ganglion cell axon guidance (GO:0031290)	2.69124523
86	cellular ketone body metabolic process (GO:0046950)	2.67442984
87	activated T cell proliferation (GO:0050798)	2.66963029
88	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.66553491
89	protein complex biogenesis (GO:0070271)	2.64740185
90	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.64574744
91	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.64574744
92	respiratory electron transport chain (GO:0022904)	2.63912803
93	viral protein processing (GO:0019082)	2.63386995
94	epithelial cilium movement (GO:0003351)	2.63070343
95	histone H2A acetylation (GO:0043968)	2.62776643
96	regulation of energy homeostasis (GO:2000505)	2.60377102
97	cilium morphogenesis (GO:0060271)	2.58641291
98	fear response (GO:0042596)	2.57040637
99	endoderm formation (GO:0001706)	2.55789630
100	T-helper 1 type immune response (GO:0042088)	2.53695835

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RBPJ_22232070_ChIP-Seq_NCS_Mouse	4.05631104
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.89063627
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.56801932
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.29801448
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.13036154
6	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.98276484
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.66043144
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.63559213
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.38565950
10	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.34981299
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.33729636
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.33486637
13	VDR_22108803_ChIP-Seq_LS180_Human	2.33415534
14	FUS_26573619_Chip-Seq_HEK293_Human	2.19954593
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.18481637
16	EWS_26573619_Chip-Seq_HEK293_Human	2.15373287
17	P300_19829295_ChIP-Seq_ESCs_Human	2.06029544
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.05115637
19	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.04347858
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.96471619
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.95078657
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.93673233
23	RNF2_27304074_Chip-Seq_NSC_Mouse	1.93127871
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.89392848
25	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.85357482
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.85243840
27	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.82177387
28	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.68378915
29	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.63662493
30	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.57028516
31	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.53429248
32	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.52032295
33	GBX2_23144817_ChIP-Seq_PC3_Human	1.49471081
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.46473025
35	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.44748093
36	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.44663165
37	REST_21632747_ChIP-Seq_MESCs_Mouse	1.41111212
38	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.40817704
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.40778187
40	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.39664765
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.37297946
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.37226120
43	IGF1R_20145208_ChIP-Seq_DFB_Human	1.36978645
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34928937
45	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.34776110
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34065436
47	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30282620
48	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.28291266
49	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.27690260
50	SMAD4_21799915_ChIP-Seq_A2780_Human	1.27148554
51	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26201342
52	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.26172023
53	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.25226332
54	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.24973450
55	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.24624237
56	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19851937
57	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.19851937
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.19252439
59	AR_20517297_ChIP-Seq_VCAP_Human	1.18572275
60	HTT_18923047_ChIP-ChIP_STHdh_Human	1.18038444
61	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.16336224
62	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16293913
63	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.14980195
64	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.13121755
65	MYC_18940864_ChIP-ChIP_HL60_Human	1.12546625
66	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.11950662
67	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.11856640
68	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.11800102
69	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.11100577
70	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.10412657
71	TCF4_22108803_ChIP-Seq_LS180_Human	1.10142084
72	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.09089392
73	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08841519
74	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.06659959
75	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.06569670
76	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.05163440
77	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.04965901
78	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.02872195
79	BCAT_22108803_ChIP-Seq_LS180_Human	1.02193597
80	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.00650846
81	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.00628861
82	CBP_20019798_ChIP-Seq_JUKART_Human	1.00628861
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00273804
84	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.99974195
85	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99199007
86	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.97976393
87	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.97386105
88	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.95612411
89	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.95612411
90	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.95558081
91	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.95502581
92	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.95502581
93	NCOR_22424771_ChIP-Seq_293T_Human	0.95238353
94	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.94387378
95	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.94245341
96	STAT3_23295773_ChIP-Seq_U87_Human	0.93931605
97	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.93906826
98	AR_21572438_ChIP-Seq_LNCaP_Human	0.91628380
99	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.91146715
100	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.90897921

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	4.66678325
2	MP0005423_abnormal_somatic_nervous	3.64767004
3	MP0008789_abnormal_olfactory_epithelium	3.28453777
4	MP0003880_abnormal_central_pattern	3.23111327
5	MP0005187_abnormal_penis_morphology	3.22213242
6	MP0006292_abnormal_olfactory_placode	3.14224839
7	MP0005499_abnormal_olfactory_system	3.01793224
8	MP0005394_taste/olfaction_phenotype	3.01793224
9	MP0002653_abnormal_ependyma_morphology	2.74004684
10	MP0004142_abnormal_muscle_tone	2.64452818
11	MP0004133_heterotaxia	2.44053754
12	MP0000383_abnormal_hair_follicle	2.34373542
13	MP0003136_yellow_coat_color	2.34001591
14	MP0004885_abnormal_endolymph	2.29933031
15	MP0006276_abnormal_autonomic_nervous	2.24114140
16	MP0002163_abnormal_gland_morphology	2.15170404
17	MP0010386_abnormal_urinary_bladder	2.09105783
18	MP0003195_calcinosis	1.98987938
19	MP0005379_endocrine/exocrine_gland_phen	1.91430560
20	MP0002277_abnormal_respiratory_mucosa	1.86120641
21	MP0010030_abnormal_orbit_morphology	1.84850322
22	MP0008961_abnormal_basal_metabolism	1.74553442
23	MP0009840_abnormal_foam_cell	1.70741148
24	MP0003806_abnormal_nucleotide_metabolis	1.70578986
25	MP0005646_abnormal_pituitary_gland	1.69170976
26	MP0003283_abnormal_digestive_organ	1.68349672
27	MP0001529_abnormal_vocalization	1.66182169
28	MP0000647_abnormal_sebaceous_gland	1.65366224
29	MP0004270_analgesia	1.65290271
30	MP0002638_abnormal_pupillary_reflex	1.63865173
31	MP0003011_delayed_dark_adaptation	1.59338618
32	MP0000778_abnormal_nervous_system	1.56467037
33	MP0001440_abnormal_grooming_behavior	1.50427767
34	MP0001984_abnormal_olfaction	1.50220012
35	MP0000631_abnormal_neuroendocrine_gland	1.49541972
36	MP0002938_white_spotting	1.48945213
37	MP0005645_abnormal_hypothalamus_physiol	1.47107758
38	MP0000538_abnormal_urinary_bladder	1.46850372
39	MP0005551_abnormal_eye_electrophysiolog	1.46489799
40	MP0002282_abnormal_trachea_morphology	1.45738843
41	MP0003724_increased_susceptibility_to	1.44439262
42	MP0002822_catalepsy	1.43461095
43	MP0002095_abnormal_skin_pigmentation	1.31602346
44	MP0009745_abnormal_behavioral_response	1.29302679
45	MP0002233_abnormal_nose_morphology	1.27372473
46	MP0000427_abnormal_hair_cycle	1.26683864
47	MP0001293_anophthalmia	1.26595658
48	MP0003959_abnormal_lean_body	1.26297377
49	MP0002102_abnormal_ear_morphology	1.25434279
50	MP0006072_abnormal_retinal_apoptosis	1.21796352
51	MP0001486_abnormal_startle_reflex	1.18757357
52	MP0003191_abnormal_cellular_cholesterol	1.16101666
53	MP0003635_abnormal_synaptic_transmissio	1.15519290
54	MP0010678_abnormal_skin_adnexa	1.15441399
55	MP0001879_abnormal_lymphatic_vessel	1.14388633
56	MP0005410_abnormal_fertilization	1.12738756
57	MP0005448_abnormal_energy_balance	1.11964684
58	MP0002557_abnormal_social/conspecific_i	1.10109602
59	MP0004782_abnormal_surfactant_physiolog	1.09613653
60	MP0000685_abnormal_immune_system	1.08323482
61	MP0003890_abnormal_embryonic-extraembry	1.07060844
62	MP0008569_lethality_at_weaning	1.04254912
63	MP0003938_abnormal_ear_development	0.99383158
64	MP0002572_abnormal_emotion/affect_behav	0.97909522
65	MP0002272_abnormal_nervous_system	0.94849476
66	MP0002063_abnormal_learning/memory/cond	0.94108949
67	MP0000537_abnormal_urethra_morphology	0.92831723
68	MP0005253_abnormal_eye_physiology	0.92776197
69	MP0000579_abnormal_nail_morphology	0.91493110
70	MP0002064_seizures	0.87695439
71	MP0001502_abnormal_circadian_rhythm	0.86800052
72	MP0002837_dystrophic_cardiac_calcinosis	0.85897071
73	MP0002752_abnormal_somatic_nervous	0.84161969
74	MP0002067_abnormal_sensory_capabilities	0.83789223
75	MP0001485_abnormal_pinna_reflex	0.82016335
76	MP0008995_early_reproductive_senescence	0.82015647
77	MP0005535_abnormal_body_temperature	0.81998753
78	MP0003828_pulmonary_edema	0.81144931
79	MP0000955_abnormal_spinal_cord	0.79583003
80	MP0005058_abnormal_lysosome_morphology	0.79379642
81	MP0002882_abnormal_neuron_morphology	0.76649658
82	MP0002127_abnormal_cardiovascular_syste	0.72944231
83	MP0005167_abnormal_blood-brain_barrier	0.71806049
84	MP0001501_abnormal_sleep_pattern	0.71628794
85	MP0003436_decreased_susceptibility_to	0.71193807
86	MP0002069_abnormal_eating/drinking_beha	0.70502055
87	MP0008872_abnormal_physiological_respon	0.70448188
88	MP0003937_abnormal_limbs/digits/tail_de	0.68963907
89	MP0008875_abnormal_xenobiotic_pharmacok	0.68461402
90	MP0009384_cardiac_valve_regurgitation	0.68081667
91	MP0000639_abnormal_adrenal_gland	0.67113090
92	MP0004742_abnormal_vestibular_system	0.65578710
93	MP0005195_abnormal_posterior_eye	0.64918965
94	MP0001919_abnormal_reproductive_system	0.61588388
95	MP0002405_respiratory_system_inflammati	0.61138817
96	MP0000026_abnormal_inner_ear	0.60552449
97	MP0002751_abnormal_autonomic_nervous	0.59942330
98	MP0004019_abnormal_vitamin_homeostasis	0.59642967
99	MP0004859_abnormal_synaptic_plasticity	0.59507312
100	MP0002909_abnormal_adrenal_gland	0.59256622

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Rhinitis (HP:0012384)	4.67829460
2	Increased density of long bones (HP:0006392)	4.39091650
3	Increased hepatocellular lipid droplets (HP:0006565)	4.34377561
4	Pancreatic fibrosis (HP:0100732)	4.20565642
5	Premature loss of primary teeth (HP:0006323)	4.12408588
6	Pancreatic cysts (HP:0001737)	3.99789708
7	Persistence of primary teeth (HP:0006335)	3.94141285
8	Chronic hepatic failure (HP:0100626)	3.87222195
9	Abnormality of the labia minora (HP:0012880)	3.78718098
10	Lipid accumulation in hepatocytes (HP:0006561)	3.70447152
11	True hermaphroditism (HP:0010459)	3.69227447
12	Abnormality of abdominal situs (HP:0011620)	3.63933876
13	Abdominal situs inversus (HP:0003363)	3.63933876
14	Retinal dysplasia (HP:0007973)	3.49552804
15	Optic nerve hypoplasia (HP:0000609)	3.47556938
16	Type II lissencephaly (HP:0007260)	3.30854601
17	Renal Fanconi syndrome (HP:0001994)	3.12048208
18	3-Methylglutaconic aciduria (HP:0003535)	3.06877425
19	Rib fusion (HP:0000902)	3.06123295
20	Asymmetric septal hypertrophy (HP:0001670)	2.88652913
21	Abnormal ciliary motility (HP:0012262)	2.85514525
22	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.84017379
23	Mitochondrial inheritance (HP:0001427)	2.79696961
24	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.69109795
25	Hypoplasia of the fovea (HP:0007750)	2.69109795
26	Ependymoma (HP:0002888)	2.66503141
27	Septo-optic dysplasia (HP:0100842)	2.66171412
28	Abnormal respiratory motile cilium physiology (HP:0012261)	2.60126502
29	Abnormality of the renal medulla (HP:0100957)	2.59026507
30	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.54916682
31	Abnormal respiratory epithelium morphology (HP:0012253)	2.54316332
32	Abnormal respiratory motile cilium morphology (HP:0005938)	2.54316332
33	Abnormality of the renal cortex (HP:0011035)	2.53138535
34	Anencephaly (HP:0002323)	2.46157582
35	Supernumerary spleens (HP:0009799)	2.45149942
36	Cystic liver disease (HP:0006706)	2.42063260
37	Increased CSF lactate (HP:0002490)	2.38619451
38	Exertional dyspnea (HP:0002875)	2.37889342
39	Oligodactyly (hands) (HP:0001180)	2.34779201
40	Lissencephaly (HP:0001339)	2.32639531
41	Large for gestational age (HP:0001520)	2.32567773
42	Acute necrotizing encephalopathy (HP:0006965)	2.28703484
43	Agnosia (HP:0010524)	2.27461043
44	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.26187830
45	Thyroid-stimulating hormone excess (HP:0002925)	2.25853397
46	Nephronophthisis (HP:0000090)	2.25167286
47	Sclerocornea (HP:0000647)	2.23117047
48	Esophageal atresia (HP:0002032)	2.20889686
49	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.19908952
50	Abnormality of polysaccharide metabolism (HP:0011012)	2.19908952
51	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.19908952
52	Occipital encephalocele (HP:0002085)	2.19880140
53	Molar tooth sign on MRI (HP:0002419)	2.17328171
54	Abnormality of midbrain morphology (HP:0002418)	2.17328171
55	Urinary glycosaminoglycan excretion (HP:0003541)	2.15536654
56	Mucopolysacchariduria (HP:0008155)	2.15536654
57	Increased intramyocellular lipid droplets (HP:0012240)	2.13574717
58	Cerebellar dysplasia (HP:0007033)	2.12813043
59	Rhabdomyosarcoma (HP:0002859)	2.11798657
60	Abnormality of primary teeth (HP:0006481)	2.11502112
61	Absent septum pellucidum (HP:0001331)	2.10786073
62	Abnormality of the fovea (HP:0000493)	2.10589872
63	Abnormality of renal resorption (HP:0011038)	2.06146308
64	Astrocytoma (HP:0009592)	2.06139637
65	Abnormality of the astrocytes (HP:0100707)	2.06139637
66	Pendular nystagmus (HP:0012043)	2.05747881
67	Thyroiditis (HP:0100646)	2.04531530
68	Tented upper lip vermilion (HP:0010804)	1.99502537
69	Progressive macrocephaly (HP:0004481)	1.97531083
70	Stenosis of the external auditory canal (HP:0000402)	1.96073881
71	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.92879241
72	Severe combined immunodeficiency (HP:0004430)	1.92460347
73	Male pseudohermaphroditism (HP:0000037)	1.92204839
74	Medulloblastoma (HP:0002885)	1.90335820
75	Abnormality of the septum pellucidum (HP:0007375)	1.90197482
76	Abnormal mitochondria in muscle tissue (HP:0008316)	1.88305127
77	Abnormal ventriculo-arterial connection (HP:0011563)	1.86300124
78	Transposition of the great arteries (HP:0001669)	1.86300124
79	Abnormal connection of the cardiac segments (HP:0011545)	1.86300124
80	Ovoid vertebral bodies (HP:0003300)	1.85677566
81	Congenital, generalized hypertrichosis (HP:0004540)	1.85388479
82	Glioma (HP:0009733)	1.85133023
83	Methylmalonic acidemia (HP:0002912)	1.84963043
84	Volvulus (HP:0002580)	1.84322398
85	Bile duct proliferation (HP:0001408)	1.81977767
86	Abnormal biliary tract physiology (HP:0012439)	1.81977767
87	Maternal diabetes (HP:0009800)	1.81629042
88	Type 2 muscle fiber atrophy (HP:0003554)	1.79721931
89	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.79584015
90	Intellectual disability, moderate (HP:0002342)	1.78434569
91	Double outlet right ventricle (HP:0001719)	1.78026138
92	Congenital malformation of the right heart (HP:0011723)	1.78026138
93	Respiratory difficulties (HP:0002880)	1.76536583
94	Spastic tetraplegia (HP:0002510)	1.75578744
95	Decreased central vision (HP:0007663)	1.74592135
96	Congenital stationary night blindness (HP:0007642)	1.73827210
97	Postaxial foot polydactyly (HP:0001830)	1.72285075
98	Abolished electroretinogram (ERG) (HP:0000550)	1.71136479
99	Neoplasm of striated muscle (HP:0009728)	1.70984350
100	Xerostomia (HP:0000217)	1.69770335

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	7.45291839
2	WNK3	3.47859458
3	EPHA4	3.33280276
4	MAP2K2	3.05546556
5	TLK1	2.97268058
6	MAP4K2	2.86651767
7	MARK1	2.64658011
8	FGFR2	2.63110023
9	BCKDK	2.56418636
10	TRIM28	2.37208700
11	CDK8	2.28885238
12	CDC42BPA	2.27765763
13	DYRK3	1.79163709
14	ERBB3	1.61668803
15	LMTK2	1.56938303
16	EPHA3	1.56706354
17	ZAK	1.55793294
18	NEK9	1.54739239
19	SIK2	1.51832112
20	PASK	1.38063987
21	PINK1	1.36886973
22	TESK2	1.30536277
23	GRK7	1.27023334
24	PAK3	1.21328979
25	MAPK13	1.18827283
26	GRK1	1.18368811
27	SRPK1	1.15537560
28	FRK	1.13790074
29	MAP3K7	1.13514191
30	MAP3K4	1.09482942
31	BCR	1.08611946
32	NTRK2	1.07732493
33	BMPR1B	1.03574933
34	ADRBK2	1.02871147
35	MAP2K1	1.02475442
36	DYRK1A	1.00492813
37	DYRK2	0.99827747
38	MST4	0.98852580
39	TNIK	0.83740133
40	PRKACB	0.83247034
41	ALK	0.78527539
42	MAP3K12	0.77894338
43	ADRBK1	0.76504441
44	INSRR	0.72663857
45	NTRK3	0.71170394
46	MINK1	0.69147032
47	WNK4	0.68578578
48	UHMK1	0.67644098
49	EIF2AK3	0.66761375
50	CAMKK2	0.62279604
51	GRK6	0.59335917
52	FGFR1	0.58971936
53	PRKCH	0.57472041
54	PRKG1	0.57285158
55	NLK	0.56385958
56	DAPK2	0.56128166
57	PRKCE	0.54151463
58	MATK	0.53935241
59	NME1	0.52380605
60	PRKCZ	0.51908732
61	MAP2K7	0.50920329
62	TXK	0.49579628
63	OBSCN	0.46648020
64	TNK2	0.45440001
65	PLK4	0.45296231
66	ACVR1B	0.44710994
67	CDK5	0.43627932
68	STK38L	0.42742514
69	STK39	0.42468733
70	PRKCG	0.42296156
71	PRKACA	0.40226157
72	EPHB2	0.39940777
73	STK11	0.39726472
74	BRSK2	0.37577070
75	MAP2K6	0.37449439
76	CSNK1G2	0.37184777
77	STK3	0.36628360
78	MAP2K4	0.36289015
79	OXSR1	0.36277395
80	CSNK2A2	0.34908377
81	RPS6KA5	0.34297614
82	PRKD3	0.33713412
83	AURKB	0.33139883
84	CHUK	0.33088265
85	BMPR2	0.32863826
86	AURKA	0.32146290
87	ABL2	0.31310472
88	CSNK1A1	0.31195725
89	CSNK1G3	0.30980113
90	RPS6KA3	0.30031683
91	STK16	0.29682842
92	PRKACG	0.29028864
93	CAMK2A	0.28057431
94	PRKCA	0.27970137
95	TGFBR1	0.26051142
96	MELK	0.25318792
97	CDK9	0.25260410
98	PRKCB	0.25104245
99	SIK3	0.24982265
100	CSNK1A1L	0.23925086

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	8.46585441
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.13971049
3	Parkinsons disease_Homo sapiens_hsa05012	2.63040605
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.60718292
5	Phenylalanine metabolism_Homo sapiens_hsa00360	2.53352016
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.42601808
7	Nicotine addiction_Homo sapiens_hsa05033	2.26720060
8	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.24025337
9	Caffeine metabolism_Homo sapiens_hsa00232	2.21954741
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.95980730
11	Huntingtons disease_Homo sapiens_hsa05016	1.90234028
12	Mismatch repair_Homo sapiens_hsa03430	1.87925553
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.82250894
14	Alzheimers disease_Homo sapiens_hsa05010	1.81969410
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.68805437
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.64990933
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.60332581
18	Sulfur metabolism_Homo sapiens_hsa00920	1.58246995
19	RNA polymerase_Homo sapiens_hsa03020	1.51914887
20	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.44213398
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.41354776
22	Morphine addiction_Homo sapiens_hsa05032	1.40881514
23	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.40845964
24	Tyrosine metabolism_Homo sapiens_hsa00350	1.40052153
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.39805042
26	Ribosome_Homo sapiens_hsa03010	1.38947222
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.37650584
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.37427702
29	Collecting duct acid secretion_Homo sapiens_hsa04966	1.30339471
30	Phototransduction_Homo sapiens_hsa04744	1.29307677
31	Serotonergic synapse_Homo sapiens_hsa04726	1.27904546
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.11049345
33	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.09036636
34	Butanoate metabolism_Homo sapiens_hsa00650	1.08570294
35	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.08195592
36	Linoleic acid metabolism_Homo sapiens_hsa00591	1.07879048
37	Taste transduction_Homo sapiens_hsa04742	1.06897430
38	GABAergic synapse_Homo sapiens_hsa04727	1.05434215
39	Arginine biosynthesis_Homo sapiens_hsa00220	0.99672950
40	Homologous recombination_Homo sapiens_hsa03440	0.98015468
41	Proteasome_Homo sapiens_hsa03050	0.95484982
42	Basal transcription factors_Homo sapiens_hsa03022	0.92416562
43	Steroid biosynthesis_Homo sapiens_hsa00100	0.89550879
44	Protein export_Homo sapiens_hsa03060	0.84959961
45	Basal cell carcinoma_Homo sapiens_hsa05217	0.78855209
46	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.77332438
47	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.73829277
48	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.72944089
49	ABC transporters_Homo sapiens_hsa02010	0.72294586
50	Insulin secretion_Homo sapiens_hsa04911	0.71487791
51	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.71145786
52	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.70161219
53	Alcoholism_Homo sapiens_hsa05034	0.69242114
54	Purine metabolism_Homo sapiens_hsa00230	0.68753319
55	Peroxisome_Homo sapiens_hsa04146	0.67597230
56	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.66586905
57	Glutamatergic synapse_Homo sapiens_hsa04724	0.66497103
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.64059600
59	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.61755486
60	Axon guidance_Homo sapiens_hsa04360	0.61205402
61	Circadian rhythm_Homo sapiens_hsa04710	0.54169872
62	Olfactory transduction_Homo sapiens_hsa04740	0.52067784
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.51552340
64	Retinol metabolism_Homo sapiens_hsa00830	0.50795074
65	Rheumatoid arthritis_Homo sapiens_hsa05323	0.49806705
66	Mineral absorption_Homo sapiens_hsa04978	0.48426337
67	Folate biosynthesis_Homo sapiens_hsa00790	0.46019710
68	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.45711950
69	Metabolic pathways_Homo sapiens_hsa01100	0.45538259
70	Pentose phosphate pathway_Homo sapiens_hsa00030	0.44012996
71	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.43653317
72	Circadian entrainment_Homo sapiens_hsa04713	0.41610225
73	Cholinergic synapse_Homo sapiens_hsa04725	0.40867678
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.39257568
75	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.39086286
76	Fat digestion and absorption_Homo sapiens_hsa04975	0.37701333
77	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.36732370
78	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.36171013
79	Chemical carcinogenesis_Homo sapiens_hsa05204	0.32677457
80	Dopaminergic synapse_Homo sapiens_hsa04728	0.32491790
81	Ether lipid metabolism_Homo sapiens_hsa00565	0.31578528
82	Selenocompound metabolism_Homo sapiens_hsa00450	0.30890446
83	Renin-angiotensin system_Homo sapiens_hsa04614	0.30479622
84	RNA transport_Homo sapiens_hsa03013	0.30266503
85	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.30199682
86	Hippo signaling pathway_Homo sapiens_hsa04390	0.29918747
87	Arginine and proline metabolism_Homo sapiens_hsa00330	0.28800806
88	Cocaine addiction_Homo sapiens_hsa05030	0.28450924
89	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.28106508
90	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.28098300
91	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.27733548
92	Nucleotide excision repair_Homo sapiens_hsa03420	0.27712444
93	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.27400124
94	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.27326923
95	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.27280898
96	Pyrimidine metabolism_Homo sapiens_hsa00240	0.25969394
97	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.23510007
98	RNA degradation_Homo sapiens_hsa03018	0.21219175
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.19697031
100	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.19495747

FAM92A1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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