FAM92A1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)7.43058553
2interleukin-1-mediated signaling pathway (GO:0070498)7.06905434
3positive regulation of prostaglandin secretion (GO:0032308)6.45822399
4positive regulation of heat generation (GO:0031652)6.12560681
5regulation of fever generation (GO:0031620)5.53515975
6otic vesicle formation (GO:0030916)5.52296298
7regulation of prostaglandin secretion (GO:0032306)5.28869679
8regulation of heat generation (GO:0031650)5.12974428
9serotonin receptor signaling pathway (GO:0007210)4.89141959
10platelet dense granule organization (GO:0060155)4.88303875
11positive regulation of dendritic spine morphogenesis (GO:0061003)4.85459901
12neurofilament cytoskeleton organization (GO:0060052)4.50195691
13positive regulation of osteoclast differentiation (GO:0045672)4.43725875
14sequestering of actin monomers (GO:0042989)4.42672360
15regulation of phospholipid biosynthetic process (GO:0071071)4.35558234
16axoneme assembly (GO:0035082)4.25072080
17positive regulation of icosanoid secretion (GO:0032305)4.23552355
18establishment of protein localization to mitochondrial membrane (GO:0090151)4.10875057
19sulfation (GO:0051923)4.10285014
20regulation of interleukin-12 biosynthetic process (GO:0045075)4.09921319
21presynaptic membrane organization (GO:0097090)3.96549759
22synaptic transmission, cholinergic (GO:0007271)3.95652504
23protein-cofactor linkage (GO:0018065)3.95304048
24positive regulation of fatty acid transport (GO:2000193)3.89854264
25regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.79211368
26regulation of mitotic spindle checkpoint (GO:1903504)3.79211368
27auditory behavior (GO:0031223)3.79187471
28regulation of immunoglobulin secretion (GO:0051023)3.73800012
29anterograde synaptic vesicle transport (GO:0048490)3.68486413
30positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.62547463
31regulation of appetite (GO:0032098)3.60649260
32calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.54456039
33amyloid precursor protein catabolic process (GO:0042987)3.36917893
34lateral sprouting from an epithelium (GO:0060601)3.34340870
35response to lipoprotein particle (GO:0055094)3.34200102
36mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.32404706
37positive regulation of T cell cytokine production (GO:0002726)3.32219762
38epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31568415
39short-term memory (GO:0007614)3.30872838
40regulation of action potential (GO:0098900)3.28994040
41histone H4-K12 acetylation (GO:0043983)3.26683467
42protein polyglutamylation (GO:0018095)3.24358700
43reflex (GO:0060004)3.24136252
44bone resorption (GO:0045453)3.22845217
45multicellular organism reproduction (GO:0032504)3.20540709
46pyrimidine nucleobase catabolic process (GO:0006208)3.19435074
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.17823308
48ATP synthesis coupled proton transport (GO:0015986)3.17823308
49positive regulation of transcription regulatory region DNA binding (GO:2000679)3.16409103
50detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.15413966
51presynaptic membrane assembly (GO:0097105)3.14685724
52postsynaptic membrane organization (GO:0001941)3.12265337
53neuron fate determination (GO:0048664)3.08406501
54regulation of glucokinase activity (GO:0033131)3.08387698
55regulation of hexokinase activity (GO:1903299)3.08387698
56anterograde axon cargo transport (GO:0008089)3.01943858
57phospholipid homeostasis (GO:0055091)3.00557417
58activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.98881620
59limb bud formation (GO:0060174)2.98807088
60axonal fasciculation (GO:0007413)2.95455595
61regulation of icosanoid secretion (GO:0032303)2.89853144
62regulation of dopamine secretion (GO:0014059)2.88600904
63mitochondrial respiratory chain complex I assembly (GO:0032981)2.87356053
64NADH dehydrogenase complex assembly (GO:0010257)2.87356053
65mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.87356053
66response to auditory stimulus (GO:0010996)2.87355401
67mechanosensory behavior (GO:0007638)2.86990474
68positive regulation of organic acid transport (GO:0032892)2.86743609
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.85474495
70regulation of male gonad development (GO:2000018)2.81120800
71glutamine family amino acid biosynthetic process (GO:0009084)2.78763523
72electron transport chain (GO:0022900)2.78672890
73regulation of dendritic spine morphogenesis (GO:0061001)2.77802557
74negative regulation of oligodendrocyte differentiation (GO:0048715)2.77059551
75behavioral fear response (GO:0001662)2.74892315
76behavioral defense response (GO:0002209)2.74892315
77monocyte chemotaxis (GO:0002548)2.74577595
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73815630
79nucleobase catabolic process (GO:0046113)2.73495882
80positive regulation of bone resorption (GO:0045780)2.73305223
81positive regulation of bone remodeling (GO:0046852)2.73305223
82ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.73250765
83forebrain morphogenesis (GO:0048853)2.72834110
84synapse assembly (GO:0007416)2.72412182
85retinal ganglion cell axon guidance (GO:0031290)2.69124523
86cellular ketone body metabolic process (GO:0046950)2.67442984
87activated T cell proliferation (GO:0050798)2.66963029
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.66553491
89protein complex biogenesis (GO:0070271)2.64740185
90somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64574744
91somatic hypermutation of immunoglobulin genes (GO:0016446)2.64574744
92respiratory electron transport chain (GO:0022904)2.63912803
93viral protein processing (GO:0019082)2.63386995
94epithelial cilium movement (GO:0003351)2.63070343
95histone H2A acetylation (GO:0043968)2.62776643
96regulation of energy homeostasis (GO:2000505)2.60377102
97cilium morphogenesis (GO:0060271)2.58641291
98fear response (GO:0042596)2.57040637
99endoderm formation (GO:0001706)2.55789630
100T-helper 1 type immune response (GO:0042088)2.53695835

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.05631104
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.89063627
3EZH2_22144423_ChIP-Seq_EOC_Human3.56801932
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.29801448
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.13036154
6CBX2_27304074_Chip-Seq_ESCs_Mouse2.98276484
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66043144
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.63559213
9ZNF274_21170338_ChIP-Seq_K562_Hela2.38565950
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.34981299
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33729636
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.33486637
13VDR_22108803_ChIP-Seq_LS180_Human2.33415534
14FUS_26573619_Chip-Seq_HEK293_Human2.19954593
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.18481637
16EWS_26573619_Chip-Seq_HEK293_Human2.15373287
17P300_19829295_ChIP-Seq_ESCs_Human2.06029544
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05115637
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.04347858
20TAF15_26573619_Chip-Seq_HEK293_Human1.96471619
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.95078657
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.93673233
23RNF2_27304074_Chip-Seq_NSC_Mouse1.93127871
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.89392848
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.85357482
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85243840
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82177387
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68378915
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.63662493
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.57028516
31GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.53429248
32AUTS2_25519132_ChIP-Seq_293T-REX_Human1.52032295
33GBX2_23144817_ChIP-Seq_PC3_Human1.49471081
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46473025
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44748093
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44663165
37REST_21632747_ChIP-Seq_MESCs_Mouse1.41111212
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40817704
39ER_23166858_ChIP-Seq_MCF-7_Human1.40778187
40SOX2_16153702_ChIP-ChIP_HESCs_Human1.39664765
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37297946
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37226120
43IGF1R_20145208_ChIP-Seq_DFB_Human1.36978645
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34928937
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.34776110
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34065436
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30282620
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28291266
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27690260
50SMAD4_21799915_ChIP-Seq_A2780_Human1.27148554
51RUNX2_22187159_ChIP-Seq_PCA_Human1.26201342
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26172023
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25226332
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24973450
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24624237
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19851937
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19851937
58TP53_22573176_ChIP-Seq_HFKS_Human1.19252439
59AR_20517297_ChIP-Seq_VCAP_Human1.18572275
60HTT_18923047_ChIP-ChIP_STHdh_Human1.18038444
61FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16336224
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16293913
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.14980195
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13121755
65MYC_18940864_ChIP-ChIP_HL60_Human1.12546625
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.11950662
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11856640
68TAL1_26923725_Chip-Seq_HPCs_Mouse1.11800102
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11100577
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10412657
71TCF4_22108803_ChIP-Seq_LS180_Human1.10142084
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.09089392
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08841519
74PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06659959
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06569670
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05163440
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.04965901
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.02872195
79BCAT_22108803_ChIP-Seq_LS180_Human1.02193597
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00650846
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00628861
82CBP_20019798_ChIP-Seq_JUKART_Human1.00628861
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00273804
84NOTCH1_21737748_ChIP-Seq_TLL_Human0.99974195
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99199007
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97976393
87SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97386105
88RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95612411
89EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95612411
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95558081
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95502581
92FOXA1_25329375_ChIP-Seq_VCAP_Human0.95502581
93NCOR_22424771_ChIP-Seq_293T_Human0.95238353
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94387378
95RNF2_27304074_Chip-Seq_ESCs_Mouse0.94245341
96STAT3_23295773_ChIP-Seq_U87_Human0.93931605
97ETS1_20019798_ChIP-Seq_JURKAT_Human0.93906826
98AR_21572438_ChIP-Seq_LNCaP_Human0.91628380
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91146715
100P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90897921

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.66678325
2MP0005423_abnormal_somatic_nervous3.64767004
3MP0008789_abnormal_olfactory_epithelium3.28453777
4MP0003880_abnormal_central_pattern3.23111327
5MP0005187_abnormal_penis_morphology3.22213242
6MP0006292_abnormal_olfactory_placode3.14224839
7MP0005499_abnormal_olfactory_system3.01793224
8MP0005394_taste/olfaction_phenotype3.01793224
9MP0002653_abnormal_ependyma_morphology2.74004684
10MP0004142_abnormal_muscle_tone2.64452818
11MP0004133_heterotaxia2.44053754
12MP0000383_abnormal_hair_follicle2.34373542
13MP0003136_yellow_coat_color2.34001591
14MP0004885_abnormal_endolymph2.29933031
15MP0006276_abnormal_autonomic_nervous2.24114140
16MP0002163_abnormal_gland_morphology2.15170404
17MP0010386_abnormal_urinary_bladder2.09105783
18MP0003195_calcinosis1.98987938
19MP0005379_endocrine/exocrine_gland_phen1.91430560
20MP0002277_abnormal_respiratory_mucosa1.86120641
21MP0010030_abnormal_orbit_morphology1.84850322
22MP0008961_abnormal_basal_metabolism1.74553442
23MP0009840_abnormal_foam_cell1.70741148
24MP0003806_abnormal_nucleotide_metabolis1.70578986
25MP0005646_abnormal_pituitary_gland1.69170976
26MP0003283_abnormal_digestive_organ1.68349672
27MP0001529_abnormal_vocalization1.66182169
28MP0000647_abnormal_sebaceous_gland1.65366224
29MP0004270_analgesia1.65290271
30MP0002638_abnormal_pupillary_reflex1.63865173
31MP0003011_delayed_dark_adaptation1.59338618
32MP0000778_abnormal_nervous_system1.56467037
33MP0001440_abnormal_grooming_behavior1.50427767
34MP0001984_abnormal_olfaction1.50220012
35MP0000631_abnormal_neuroendocrine_gland1.49541972
36MP0002938_white_spotting1.48945213
37MP0005645_abnormal_hypothalamus_physiol1.47107758
38MP0000538_abnormal_urinary_bladder1.46850372
39MP0005551_abnormal_eye_electrophysiolog1.46489799
40MP0002282_abnormal_trachea_morphology1.45738843
41MP0003724_increased_susceptibility_to1.44439262
42MP0002822_catalepsy1.43461095
43MP0002095_abnormal_skin_pigmentation1.31602346
44MP0009745_abnormal_behavioral_response1.29302679
45MP0002233_abnormal_nose_morphology1.27372473
46MP0000427_abnormal_hair_cycle1.26683864
47MP0001293_anophthalmia1.26595658
48MP0003959_abnormal_lean_body1.26297377
49MP0002102_abnormal_ear_morphology1.25434279
50MP0006072_abnormal_retinal_apoptosis1.21796352
51MP0001486_abnormal_startle_reflex1.18757357
52MP0003191_abnormal_cellular_cholesterol1.16101666
53MP0003635_abnormal_synaptic_transmissio1.15519290
54MP0010678_abnormal_skin_adnexa1.15441399
55MP0001879_abnormal_lymphatic_vessel1.14388633
56MP0005410_abnormal_fertilization1.12738756
57MP0005448_abnormal_energy_balance1.11964684
58MP0002557_abnormal_social/conspecific_i1.10109602
59MP0004782_abnormal_surfactant_physiolog1.09613653
60MP0000685_abnormal_immune_system1.08323482
61MP0003890_abnormal_embryonic-extraembry1.07060844
62MP0008569_lethality_at_weaning1.04254912
63MP0003938_abnormal_ear_development0.99383158
64MP0002572_abnormal_emotion/affect_behav0.97909522
65MP0002272_abnormal_nervous_system0.94849476
66MP0002063_abnormal_learning/memory/cond0.94108949
67MP0000537_abnormal_urethra_morphology0.92831723
68MP0005253_abnormal_eye_physiology0.92776197
69MP0000579_abnormal_nail_morphology0.91493110
70MP0002064_seizures0.87695439
71MP0001502_abnormal_circadian_rhythm0.86800052
72MP0002837_dystrophic_cardiac_calcinosis0.85897071
73MP0002752_abnormal_somatic_nervous0.84161969
74MP0002067_abnormal_sensory_capabilities0.83789223
75MP0001485_abnormal_pinna_reflex0.82016335
76MP0008995_early_reproductive_senescence0.82015647
77MP0005535_abnormal_body_temperature0.81998753
78MP0003828_pulmonary_edema0.81144931
79MP0000955_abnormal_spinal_cord0.79583003
80MP0005058_abnormal_lysosome_morphology0.79379642
81MP0002882_abnormal_neuron_morphology0.76649658
82MP0002127_abnormal_cardiovascular_syste0.72944231
83MP0005167_abnormal_blood-brain_barrier0.71806049
84MP0001501_abnormal_sleep_pattern0.71628794
85MP0003436_decreased_susceptibility_to0.71193807
86MP0002069_abnormal_eating/drinking_beha0.70502055
87MP0008872_abnormal_physiological_respon0.70448188
88MP0003937_abnormal_limbs/digits/tail_de0.68963907
89MP0008875_abnormal_xenobiotic_pharmacok0.68461402
90MP0009384_cardiac_valve_regurgitation0.68081667
91MP0000639_abnormal_adrenal_gland0.67113090
92MP0004742_abnormal_vestibular_system0.65578710
93MP0005195_abnormal_posterior_eye0.64918965
94MP0001919_abnormal_reproductive_system0.61588388
95MP0002405_respiratory_system_inflammati0.61138817
96MP0000026_abnormal_inner_ear0.60552449
97MP0002751_abnormal_autonomic_nervous0.59942330
98MP0004019_abnormal_vitamin_homeostasis0.59642967
99MP0004859_abnormal_synaptic_plasticity0.59507312
100MP0002909_abnormal_adrenal_gland0.59256622

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)4.67829460
2Increased density of long bones (HP:0006392)4.39091650
3Increased hepatocellular lipid droplets (HP:0006565)4.34377561
4Pancreatic fibrosis (HP:0100732)4.20565642
5Premature loss of primary teeth (HP:0006323)4.12408588
6Pancreatic cysts (HP:0001737)3.99789708
7Persistence of primary teeth (HP:0006335)3.94141285
8Chronic hepatic failure (HP:0100626)3.87222195
9Abnormality of the labia minora (HP:0012880)3.78718098
10Lipid accumulation in hepatocytes (HP:0006561)3.70447152
11True hermaphroditism (HP:0010459)3.69227447
12Abnormality of abdominal situs (HP:0011620)3.63933876
13Abdominal situs inversus (HP:0003363)3.63933876
14Retinal dysplasia (HP:0007973)3.49552804
15Optic nerve hypoplasia (HP:0000609)3.47556938
16Type II lissencephaly (HP:0007260)3.30854601
17Renal Fanconi syndrome (HP:0001994)3.12048208
183-Methylglutaconic aciduria (HP:0003535)3.06877425
19Rib fusion (HP:0000902)3.06123295
20Asymmetric septal hypertrophy (HP:0001670)2.88652913
21Abnormal ciliary motility (HP:0012262)2.85514525
22Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.84017379
23Mitochondrial inheritance (HP:0001427)2.79696961
24Hypoplasia of the fovea (HP:0007750)2.69109795
25Aplasia/Hypoplasia of the fovea (HP:0008060)2.69109795
26Ependymoma (HP:0002888)2.66503141
27Septo-optic dysplasia (HP:0100842)2.66171412
28Abnormal respiratory motile cilium physiology (HP:0012261)2.60126502
29Abnormality of the renal medulla (HP:0100957)2.59026507
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.54916682
31Abnormal respiratory epithelium morphology (HP:0012253)2.54316332
32Abnormal respiratory motile cilium morphology (HP:0005938)2.54316332
33Abnormality of the renal cortex (HP:0011035)2.53138535
34Anencephaly (HP:0002323)2.46157582
35Supernumerary spleens (HP:0009799)2.45149942
36Cystic liver disease (HP:0006706)2.42063260
37Increased CSF lactate (HP:0002490)2.38619451
38Exertional dyspnea (HP:0002875)2.37889342
39Oligodactyly (hands) (HP:0001180)2.34779201
40Lissencephaly (HP:0001339)2.32639531
41Large for gestational age (HP:0001520)2.32567773
42Acute necrotizing encephalopathy (HP:0006965)2.28703484
43Agnosia (HP:0010524)2.27461043
44Aplasia/Hypoplasia of the tongue (HP:0010295)2.26187830
45Thyroid-stimulating hormone excess (HP:0002925)2.25853397
46Nephronophthisis (HP:0000090)2.25167286
47Sclerocornea (HP:0000647)2.23117047
48Esophageal atresia (HP:0002032)2.20889686
49Abnormality of mucopolysaccharide metabolism (HP:0011020)2.19908952
50Abnormality of polysaccharide metabolism (HP:0011012)2.19908952
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.19908952
52Occipital encephalocele (HP:0002085)2.19880140
53Abnormality of midbrain morphology (HP:0002418)2.17328171
54Molar tooth sign on MRI (HP:0002419)2.17328171
55Mucopolysacchariduria (HP:0008155)2.15536654
56Urinary glycosaminoglycan excretion (HP:0003541)2.15536654
57Increased intramyocellular lipid droplets (HP:0012240)2.13574717
58Cerebellar dysplasia (HP:0007033)2.12813043
59Rhabdomyosarcoma (HP:0002859)2.11798657
60Abnormality of primary teeth (HP:0006481)2.11502112
61Absent septum pellucidum (HP:0001331)2.10786073
62Abnormality of the fovea (HP:0000493)2.10589872
63Abnormality of renal resorption (HP:0011038)2.06146308
64Astrocytoma (HP:0009592)2.06139637
65Abnormality of the astrocytes (HP:0100707)2.06139637
66Pendular nystagmus (HP:0012043)2.05747881
67Thyroiditis (HP:0100646)2.04531530
68Tented upper lip vermilion (HP:0010804)1.99502537
69Progressive macrocephaly (HP:0004481)1.97531083
70Stenosis of the external auditory canal (HP:0000402)1.96073881
71Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.92879241
72Severe combined immunodeficiency (HP:0004430)1.92460347
73Male pseudohermaphroditism (HP:0000037)1.92204839
74Medulloblastoma (HP:0002885)1.90335820
75Abnormality of the septum pellucidum (HP:0007375)1.90197482
76Abnormal mitochondria in muscle tissue (HP:0008316)1.88305127
77Abnormal ventriculo-arterial connection (HP:0011563)1.86300124
78Transposition of the great arteries (HP:0001669)1.86300124
79Abnormal connection of the cardiac segments (HP:0011545)1.86300124
80Ovoid vertebral bodies (HP:0003300)1.85677566
81Congenital, generalized hypertrichosis (HP:0004540)1.85388479
82Glioma (HP:0009733)1.85133023
83Methylmalonic acidemia (HP:0002912)1.84963043
84Volvulus (HP:0002580)1.84322398
85Abnormal biliary tract physiology (HP:0012439)1.81977767
86Bile duct proliferation (HP:0001408)1.81977767
87Maternal diabetes (HP:0009800)1.81629042
88Type 2 muscle fiber atrophy (HP:0003554)1.79721931
89Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79584015
90Intellectual disability, moderate (HP:0002342)1.78434569
91Congenital malformation of the right heart (HP:0011723)1.78026138
92Double outlet right ventricle (HP:0001719)1.78026138
93Respiratory difficulties (HP:0002880)1.76536583
94Spastic tetraplegia (HP:0002510)1.75578744
95Decreased central vision (HP:0007663)1.74592135
96Congenital stationary night blindness (HP:0007642)1.73827210
97Postaxial foot polydactyly (HP:0001830)1.72285075
98Abolished electroretinogram (ERG) (HP:0000550)1.71136479
99Neoplasm of striated muscle (HP:0009728)1.70984350
100Xerostomia (HP:0000217)1.69770335

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.45291839
2WNK33.47859458
3EPHA43.33280276
4MAP2K23.05546556
5TLK12.97268058
6MAP4K22.86651767
7MARK12.64658011
8FGFR22.63110023
9BCKDK2.56418636
10TRIM282.37208700
11CDK82.28885238
12CDC42BPA2.27765763
13DYRK31.79163709
14ERBB31.61668803
15LMTK21.56938303
16EPHA31.56706354
17ZAK1.55793294
18NEK91.54739239
19SIK21.51832112
20PASK1.38063987
21PINK11.36886973
22TESK21.30536277
23GRK71.27023334
24PAK31.21328979
25MAPK131.18827283
26GRK11.18368811
27SRPK11.15537560
28FRK1.13790074
29MAP3K71.13514191
30MAP3K41.09482942
31BCR1.08611946
32NTRK21.07732493
33BMPR1B1.03574933
34ADRBK21.02871147
35MAP2K11.02475442
36DYRK1A1.00492813
37DYRK20.99827747
38MST40.98852580
39TNIK0.83740133
40PRKACB0.83247034
41ALK0.78527539
42MAP3K120.77894338
43ADRBK10.76504441
44INSRR0.72663857
45NTRK30.71170394
46MINK10.69147032
47WNK40.68578578
48UHMK10.67644098
49EIF2AK30.66761375
50CAMKK20.62279604
51GRK60.59335917
52FGFR10.58971936
53PRKCH0.57472041
54PRKG10.57285158
55NLK0.56385958
56DAPK20.56128166
57PRKCE0.54151463
58MATK0.53935241
59NME10.52380605
60PRKCZ0.51908732
61MAP2K70.50920329
62TXK0.49579628
63OBSCN0.46648020
64TNK20.45440001
65PLK40.45296231
66ACVR1B0.44710994
67CDK50.43627932
68STK38L0.42742514
69STK390.42468733
70PRKCG0.42296156
71PRKACA0.40226157
72EPHB20.39940777
73STK110.39726472
74BRSK20.37577070
75MAP2K60.37449439
76CSNK1G20.37184777
77STK30.36628360
78MAP2K40.36289015
79OXSR10.36277395
80CSNK2A20.34908377
81RPS6KA50.34297614
82PRKD30.33713412
83AURKB0.33139883
84CHUK0.33088265
85BMPR20.32863826
86AURKA0.32146290
87ABL20.31310472
88CSNK1A10.31195725
89CSNK1G30.30980113
90RPS6KA30.30031683
91STK160.29682842
92PRKACG0.29028864
93CAMK2A0.28057431
94PRKCA0.27970137
95TGFBR10.26051142
96MELK0.25318792
97CDK90.25260410
98PRKCB0.25104245
99SIK30.24982265
100CSNK1A1L0.23925086

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004008.46585441
2Oxidative phosphorylation_Homo sapiens_hsa001903.13971049
3Parkinsons disease_Homo sapiens_hsa050122.63040605
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60718292
5Phenylalanine metabolism_Homo sapiens_hsa003602.53352016
6Nitrogen metabolism_Homo sapiens_hsa009102.42601808
7Nicotine addiction_Homo sapiens_hsa050332.26720060
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.24025337
9Caffeine metabolism_Homo sapiens_hsa002322.21954741
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.95980730
11Huntingtons disease_Homo sapiens_hsa050161.90234028
12Mismatch repair_Homo sapiens_hsa034301.87925553
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82250894
14Alzheimers disease_Homo sapiens_hsa050101.81969410
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68805437
16Tryptophan metabolism_Homo sapiens_hsa003801.64990933
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60332581
18Sulfur metabolism_Homo sapiens_hsa009201.58246995
19RNA polymerase_Homo sapiens_hsa030201.51914887
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44213398
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41354776
22Morphine addiction_Homo sapiens_hsa050321.40881514
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40845964
24Tyrosine metabolism_Homo sapiens_hsa003501.40052153
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39805042
26Ribosome_Homo sapiens_hsa030101.38947222
27Fanconi anemia pathway_Homo sapiens_hsa034601.37650584
28Cardiac muscle contraction_Homo sapiens_hsa042601.37427702
29Collecting duct acid secretion_Homo sapiens_hsa049661.30339471
30Phototransduction_Homo sapiens_hsa047441.29307677
31Serotonergic synapse_Homo sapiens_hsa047261.27904546
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.11049345
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.09036636
34Butanoate metabolism_Homo sapiens_hsa006501.08570294
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.08195592
36Linoleic acid metabolism_Homo sapiens_hsa005911.07879048
37Taste transduction_Homo sapiens_hsa047421.06897430
38GABAergic synapse_Homo sapiens_hsa047271.05434215
39Arginine biosynthesis_Homo sapiens_hsa002200.99672950
40Homologous recombination_Homo sapiens_hsa034400.98015468
41Proteasome_Homo sapiens_hsa030500.95484982
42Basal transcription factors_Homo sapiens_hsa030220.92416562
43Steroid biosynthesis_Homo sapiens_hsa001000.89550879
44Protein export_Homo sapiens_hsa030600.84959961
45Basal cell carcinoma_Homo sapiens_hsa052170.78855209
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77332438
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73829277
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72944089
49ABC transporters_Homo sapiens_hsa020100.72294586
50Insulin secretion_Homo sapiens_hsa049110.71487791
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71145786
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.70161219
53Alcoholism_Homo sapiens_hsa050340.69242114
54Purine metabolism_Homo sapiens_hsa002300.68753319
55Peroxisome_Homo sapiens_hsa041460.67597230
56Hedgehog signaling pathway_Homo sapiens_hsa043400.66586905
57Glutamatergic synapse_Homo sapiens_hsa047240.66497103
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64059600
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61755486
60Axon guidance_Homo sapiens_hsa043600.61205402
61Circadian rhythm_Homo sapiens_hsa047100.54169872
62Olfactory transduction_Homo sapiens_hsa047400.52067784
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51552340
64Retinol metabolism_Homo sapiens_hsa008300.50795074
65Rheumatoid arthritis_Homo sapiens_hsa053230.49806705
66Mineral absorption_Homo sapiens_hsa049780.48426337
67Folate biosynthesis_Homo sapiens_hsa007900.46019710
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45711950
69Metabolic pathways_Homo sapiens_hsa011000.45538259
70Pentose phosphate pathway_Homo sapiens_hsa000300.44012996
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43653317
72Circadian entrainment_Homo sapiens_hsa047130.41610225
73Cholinergic synapse_Homo sapiens_hsa047250.40867678
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39257568
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39086286
76Fat digestion and absorption_Homo sapiens_hsa049750.37701333
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36732370
78Vitamin B6 metabolism_Homo sapiens_hsa007500.36171013
79Chemical carcinogenesis_Homo sapiens_hsa052040.32677457
80Dopaminergic synapse_Homo sapiens_hsa047280.32491790
81Ether lipid metabolism_Homo sapiens_hsa005650.31578528
82Selenocompound metabolism_Homo sapiens_hsa004500.30890446
83Renin-angiotensin system_Homo sapiens_hsa046140.30479622
84RNA transport_Homo sapiens_hsa030130.30266503
85Arachidonic acid metabolism_Homo sapiens_hsa005900.30199682
86Hippo signaling pathway_Homo sapiens_hsa043900.29918747
87Arginine and proline metabolism_Homo sapiens_hsa003300.28800806
88Cocaine addiction_Homo sapiens_hsa050300.28450924
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28106508
90Synaptic vesicle cycle_Homo sapiens_hsa047210.28098300
91Systemic lupus erythematosus_Homo sapiens_hsa053220.27733548
92Nucleotide excision repair_Homo sapiens_hsa034200.27712444
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.27400124
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27326923
95TGF-beta signaling pathway_Homo sapiens_hsa043500.27280898
96Pyrimidine metabolism_Homo sapiens_hsa002400.25969394
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.23510007
98RNA degradation_Homo sapiens_hsa030180.21219175
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19697031
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19495747

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