ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.22262179
2	response to pheromone (GO:0019236)	4.92541017
3	water-soluble vitamin biosynthetic process (GO:0042364)	4.48966787
4	L-fucose metabolic process (GO:0042354)	4.13293652
5	L-fucose catabolic process (GO:0042355)	4.13293652
6	fucose catabolic process (GO:0019317)	4.13293652
7	indole-containing compound catabolic process (GO:0042436)	3.94546195
8	indolalkylamine catabolic process (GO:0046218)	3.94546195
9	tryptophan catabolic process (GO:0006569)	3.94546195
10	indolalkylamine metabolic process (GO:0006586)	3.93982105
11	kynurenine metabolic process (GO:0070189)	3.68174116
12	protein polyglutamylation (GO:0018095)	3.65116274
13	DNA deamination (GO:0045006)	3.63408895
14	sperm motility (GO:0030317)	3.60061980
15	piRNA metabolic process (GO:0034587)	3.54671934
16	cellular ketone body metabolic process (GO:0046950)	3.52324211
17	tryptophan metabolic process (GO:0006568)	3.50617841
18	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.49053867
19	cornea development in camera-type eye (GO:0061303)	3.45387245
20	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.41118466
21	epithelial cilium movement (GO:0003351)	3.30482188
22	protein complex biogenesis (GO:0070271)	3.26819295
23	ketone body metabolic process (GO:1902224)	3.22196982
24	protein-cofactor linkage (GO:0018065)	3.21415177
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.18767831
26	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.18767831
27	NADH dehydrogenase complex assembly (GO:0010257)	3.18767831
28	preassembly of GPI anchor in ER membrane (GO:0016254)	3.15999602
29	indole-containing compound metabolic process (GO:0042430)	3.15229146
30	detection of light stimulus involved in sensory perception (GO:0050962)	3.12989330
31	detection of light stimulus involved in visual perception (GO:0050908)	3.12989330
32	multicellular organism reproduction (GO:0032504)	3.12296568
33	primary amino compound metabolic process (GO:1901160)	3.11925926
34	DNA methylation involved in gamete generation (GO:0043046)	3.09956082
35	gamma-aminobutyric acid transport (GO:0015812)	3.09846175
36	nonmotile primary cilium assembly (GO:0035058)	3.08144242
37	somite development (GO:0061053)	3.07918143
38	reflex (GO:0060004)	3.05275271
39	mitochondrial respiratory chain complex assembly (GO:0033108)	2.97338619
40	acrosome reaction (GO:0007340)	2.96398285
41	respiratory chain complex IV assembly (GO:0008535)	2.94182331
42	axoneme assembly (GO:0035082)	2.91561088
43	sulfation (GO:0051923)	2.87150197
44	neural tube formation (GO:0001841)	2.86854028
45	neuronal action potential (GO:0019228)	2.85514609
46	mannosylation (GO:0097502)	2.83196462
47	kidney morphogenesis (GO:0060993)	2.81937133
48	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.79321620
49	regulation of cilium movement (GO:0003352)	2.74951623
50	negative regulation of telomere maintenance (GO:0032205)	2.73478961
51	amine catabolic process (GO:0009310)	2.73300834
52	cellular biogenic amine catabolic process (GO:0042402)	2.73300834
53	platelet dense granule organization (GO:0060155)	2.72569163
54	cilium organization (GO:0044782)	2.71768466
55	male meiosis (GO:0007140)	2.71169373
56	synaptic transmission, cholinergic (GO:0007271)	2.69930265
57	cilium or flagellum-dependent cell motility (GO:0001539)	2.69625932
58	regulation of action potential (GO:0098900)	2.67997559
59	cytochrome complex assembly (GO:0017004)	2.67643829
60	signal peptide processing (GO:0006465)	2.66761170
61	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.66438770
62	serotonin metabolic process (GO:0042428)	2.66153722
63	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.64032255
64	spinal cord motor neuron differentiation (GO:0021522)	2.63676071
65	cilium morphogenesis (GO:0060271)	2.63529615
66	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.63021056
67	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.63021056
68	ubiquinone biosynthetic process (GO:0006744)	2.62195426
69	protein localization to cilium (GO:0061512)	2.61206455
70	auditory receptor cell stereocilium organization (GO:0060088)	2.61166289
71	cilium assembly (GO:0042384)	2.60703473
72	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.59428693
73	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.58922536
74	behavioral response to ethanol (GO:0048149)	2.58155708
75	pyrimidine nucleobase catabolic process (GO:0006208)	2.53625764
76	cilium movement (GO:0003341)	2.52914522
77	inner ear receptor stereocilium organization (GO:0060122)	2.52042360
78	seminiferous tubule development (GO:0072520)	2.51163167
79	retinal cone cell development (GO:0046549)	2.50898741
80	regulation of hippo signaling (GO:0035330)	2.50515345
81	axonemal dynein complex assembly (GO:0070286)	2.49324589
82	RNA destabilization (GO:0050779)	2.48925825
83	transmission of nerve impulse (GO:0019226)	2.48764101
84	L-methionine salvage (GO:0071267)	2.47830643
85	L-methionine biosynthetic process (GO:0071265)	2.47830643
86	amino acid salvage (GO:0043102)	2.47830643
87	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.47317442
88	ubiquinone metabolic process (GO:0006743)	2.46413525
89	positive regulation of fatty acid transport (GO:2000193)	2.45431511
90	cell proliferation in forebrain (GO:0021846)	2.44758559
91	spermatid development (GO:0007286)	2.44683684
92	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.44275440
93	nephron epithelium morphogenesis (GO:0072088)	2.43397247
94	nephron tubule morphogenesis (GO:0072078)	2.43397247
95	adaptation of signaling pathway (GO:0023058)	2.40539746
96	GPI anchor metabolic process (GO:0006505)	2.39975995
97	regulation of neurotransmitter uptake (GO:0051580)	2.39683300
98	retinal ganglion cell axon guidance (GO:0031290)	2.37528322
99	DNA double-strand break processing (GO:0000729)	2.37442823
100	rRNA methylation (GO:0031167)	2.37079682

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.83973637
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.37485131
3	VDR_22108803_ChIP-Seq_LS180_Human	3.17731794
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.72927006
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.64659552
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.54806613
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.39965909
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.36309569
9	FUS_26573619_Chip-Seq_HEK293_Human	2.20717437
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.18798467
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.16585883
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.15199981
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.13406735
14	EWS_26573619_Chip-Seq_HEK293_Human	2.07972116
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.04336865
16	P300_19829295_ChIP-Seq_ESCs_Human	1.97898641
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.92517820
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.87690516
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.87440467
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.84875937
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.82994663
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.79325746
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.75090793
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.65585502
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.62718934
26	CBP_20019798_ChIP-Seq_JUKART_Human	1.62480517
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.62480517
28	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.59582721
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57569328
30	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.56322262
31	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.56322262
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55218976
33	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.54574416
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.52629174
35	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.52018694
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.49811296
37	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.49446162
38	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.49434705
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.46498243
40	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.45869994
41	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.43637456
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.42973166
43	REST_21632747_ChIP-Seq_MESCs_Mouse	1.42594162
44	AR_25329375_ChIP-Seq_VCAP_Human	1.41030638
45	STAT3_23295773_ChIP-Seq_U87_Human	1.39189769
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36453170
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36453170
48	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.36165330
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35253567
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34186076
51	MYC_18940864_ChIP-ChIP_HL60_Human	1.33276854
52	TCF4_23295773_ChIP-Seq_U87_Human	1.32985182
53	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.32263951
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32061494
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.30379724
56	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.29318152
57	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.29013345
58	RNF2_27304074_Chip-Seq_NSC_Mouse	1.28863631
59	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.28439373
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25767211
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25767211
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25603029
63	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24891388
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.24845224
65	TCF4_22108803_ChIP-Seq_LS180_Human	1.24018700
66	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23912998
67	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23633576
68	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.22539227
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22496655
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21347412
71	NCOR_22424771_ChIP-Seq_293T_Human	1.18089519
72	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.17807176
73	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16655214
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.15374698
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.11835800
76	AR_20517297_ChIP-Seq_VCAP_Human	1.10793314
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10519080
78	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.09447689
79	HOXB7_26014856_ChIP-Seq_BT474_Human	1.08823447
80	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.08264332
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07980851
82	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.07931889
83	TAF2_19829295_ChIP-Seq_ESCs_Human	1.06632257
84	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04478518
85	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03138513
86	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02764496
87	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.02499009
88	MYC_19829295_ChIP-Seq_ESCs_Human	1.02131065
89	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.01247027
90	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.01111910
91	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00510067
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00388147
93	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00045988
94	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.99881709
95	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98892195
96	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.98021870
97	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.97663394
98	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97116616
99	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.96333576
100	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.96321290

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.99787098
2	MP0002102_abnormal_ear_morphology	2.62658828
3	MP0002837_dystrophic_cardiac_calcinosis	2.61746269
4	MP0006292_abnormal_olfactory_placode	2.54186634
5	MP0003195_calcinosis	2.41876070
6	MP0001968_abnormal_touch/_nociception	2.41801113
7	MP0005551_abnormal_eye_electrophysiolog	2.35765904
8	MP0005646_abnormal_pituitary_gland	2.29734048
9	MP0003646_muscle_fatigue	2.27853616
10	MP0003880_abnormal_central_pattern	2.17622561
11	MP0008875_abnormal_xenobiotic_pharmacok	2.04999937
12	MP0006072_abnormal_retinal_apoptosis	2.01176769
13	MP0004885_abnormal_endolymph	1.98015628
14	MP0002736_abnormal_nociception_after	1.97676781
15	MP0005410_abnormal_fertilization	1.94255805
16	MP0005645_abnormal_hypothalamus_physiol	1.93977842
17	MP0008872_abnormal_physiological_respon	1.92673815
18	MP0003787_abnormal_imprinting	1.89682741
19	MP0009046_muscle_twitch	1.84630367
20	MP0003011_delayed_dark_adaptation	1.83882726
21	MP0009745_abnormal_behavioral_response	1.82355170
22	MP0005253_abnormal_eye_physiology	1.78207700
23	MP0002876_abnormal_thyroid_physiology	1.70646642
24	MP0001986_abnormal_taste_sensitivity	1.70390761
25	MP0002272_abnormal_nervous_system	1.67265369
26	MP0000631_abnormal_neuroendocrine_gland	1.65037049
27	MP0002938_white_spotting	1.63828306
28	MP0004133_heterotaxia	1.63249306
29	MP0005379_endocrine/exocrine_gland_phen	1.63062965
30	MP0006276_abnormal_autonomic_nervous	1.62817614
31	MP0001501_abnormal_sleep_pattern	1.61375138
32	MP0004142_abnormal_muscle_tone	1.60477553
33	MP0001486_abnormal_startle_reflex	1.54566721
34	MP0000427_abnormal_hair_cycle	1.48830009
35	MP0004145_abnormal_muscle_electrophysio	1.48377995
36	MP0004043_abnormal_pH_regulation	1.47674744
37	MP0005084_abnormal_gallbladder_morpholo	1.43720145
38	MP0000372_irregular_coat_pigmentation	1.42136243
39	MP0001984_abnormal_olfaction	1.39605126
40	MP0002160_abnormal_reproductive_system	1.37998742
41	MP0001485_abnormal_pinna_reflex	1.37250066
42	MP0005389_reproductive_system_phenotype	1.36968145
43	MP0000569_abnormal_digit_pigmentation	1.34732757
44	MP0004742_abnormal_vestibular_system	1.31574743
45	MP0002735_abnormal_chemical_nociception	1.31328949
46	MP0002638_abnormal_pupillary_reflex	1.31070669
47	MP0005423_abnormal_somatic_nervous	1.30681100
48	MP0002163_abnormal_gland_morphology	1.30579054
49	MP0005377_hearing/vestibular/ear_phenot	1.29521383
50	MP0003878_abnormal_ear_physiology	1.29521383
51	MP0002572_abnormal_emotion/affect_behav	1.29009804
52	MP0002064_seizures	1.27856075
53	MP0002138_abnormal_hepatobiliary_system	1.27568330
54	MP0003698_abnormal_male_reproductive	1.26822703
55	MP0002557_abnormal_social/conspecific_i	1.24847068
56	MP0002653_abnormal_ependyma_morphology	1.24483172
57	MP0002234_abnormal_pharynx_morphology	1.21888655
58	MP0002733_abnormal_thermal_nociception	1.19670579
59	MP0003718_maternal_effect	1.18101344
60	MP0001970_abnormal_pain_threshold	1.16453458
61	MP0004147_increased_porphyrin_level	1.15160540
62	MP0001529_abnormal_vocalization	1.14121968
63	MP0008775_abnormal_heart_ventricle	1.13131473
64	MP0008995_early_reproductive_senescence	1.12285868
65	MP0005187_abnormal_penis_morphology	1.07947264
66	MP0001919_abnormal_reproductive_system	1.07503919
67	MP0002067_abnormal_sensory_capabilities	1.06795076
68	MP0000647_abnormal_sebaceous_gland	1.05088521
69	MP0002928_abnormal_bile_duct	1.04846251
70	MP0001929_abnormal_gametogenesis	1.02406052
71	MP0000026_abnormal_inner_ear	1.02295311
72	MP0001905_abnormal_dopamine_level	1.01520884
73	MP0001502_abnormal_circadian_rhythm	1.00663783
74	MP0002734_abnormal_mechanical_nocicepti	1.00042686
75	MP0005195_abnormal_posterior_eye	0.99580547
76	MP0004924_abnormal_behavior	0.99268043
77	MP0005386_behavior/neurological_phenoty	0.99268043
78	MP0002751_abnormal_autonomic_nervous	0.98930875
79	MP0001764_abnormal_homeostasis	0.98744162
80	MP0003635_abnormal_synaptic_transmissio	0.97972309
81	MP0002063_abnormal_learning/memory/cond	0.97569410
82	MP0003121_genomic_imprinting	0.94123794
83	MP0008789_abnormal_olfactory_epithelium	0.93492363
84	MP0002184_abnormal_innervation	0.92566537
85	MP0002752_abnormal_somatic_nervous	0.92202221
86	MP0001963_abnormal_hearing_physiology	0.91127820
87	MP0002210_abnormal_sex_determination	0.90533306
88	MP0005167_abnormal_blood-brain_barrier	0.88228453
89	MP0004215_abnormal_myocardial_fiber	0.88133384
90	MP0002095_abnormal_skin_pigmentation	0.87921862
91	MP0000383_abnormal_hair_follicle	0.87347308
92	MP0000230_abnormal_systemic_arterial	0.86996787
93	MP0003119_abnormal_digestive_system	0.86969276
94	MP0000049_abnormal_middle_ear	0.86692359
95	MP0003136_yellow_coat_color	0.86645517
96	MP0002229_neurodegeneration	0.84442912
97	MP0003122_maternal_imprinting	0.80758692
98	MP0005332_abnormal_amino_acid	0.80102510
99	MP0000653_abnormal_sex_gland	0.80016657
100	MP0002909_abnormal_adrenal_gland	0.77660608

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.31554412
2	Abnormality of midbrain morphology (HP:0002418)	4.15839598
3	Molar tooth sign on MRI (HP:0002419)	4.15839598
4	Pancreatic fibrosis (HP:0100732)	4.10899213
5	True hermaphroditism (HP:0010459)	3.82551351
6	Nephronophthisis (HP:0000090)	3.70544475
7	Congenital stationary night blindness (HP:0007642)	3.55705680
8	Pendular nystagmus (HP:0012043)	3.42595436
9	Chronic hepatic failure (HP:0100626)	3.40075849
10	Abnormality of the renal medulla (HP:0100957)	3.24873750
11	Attenuation of retinal blood vessels (HP:0007843)	3.22654369
12	Type II lissencephaly (HP:0007260)	3.20247437
13	Abnormality of the renal cortex (HP:0011035)	3.08722716
14	Tubular atrophy (HP:0000092)	2.94737747
15	Medial flaring of the eyebrow (HP:0010747)	2.92528356
16	Abnormal rod and cone electroretinograms (HP:0008323)	2.92171724
17	Increased corneal curvature (HP:0100692)	2.91991088
18	Keratoconus (HP:0000563)	2.91991088
19	Hyperventilation (HP:0002883)	2.80699245
20	Cystic liver disease (HP:0006706)	2.79625809
21	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.75436231
22	Absent/shortened dynein arms (HP:0200106)	2.75436231
23	Abolished electroretinogram (ERG) (HP:0000550)	2.74890448
24	Decreased central vision (HP:0007663)	2.71109761
25	Abnormal drinking behavior (HP:0030082)	2.70054688
26	Polydipsia (HP:0001959)	2.70054688
27	Hyperalaninemia (HP:0003348)	2.68454142
28	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.68454142
29	Abnormality of alanine metabolism (HP:0010916)	2.68454142
30	Methylmalonic acidemia (HP:0002912)	2.54905588
31	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.52195122
32	Progressive cerebellar ataxia (HP:0002073)	2.50533375
33	Gaze-evoked nystagmus (HP:0000640)	2.40282258
34	Acute necrotizing encephalopathy (HP:0006965)	2.39372884
35	Anencephaly (HP:0002323)	2.34662094
36	Sclerocornea (HP:0000647)	2.30867583
37	Abnormal respiratory motile cilium morphology (HP:0005938)	2.29127438
38	Abnormal respiratory epithelium morphology (HP:0012253)	2.29127438
39	Methylmalonic aciduria (HP:0012120)	2.28008367
40	Inability to walk (HP:0002540)	2.22542232
41	Mitochondrial inheritance (HP:0001427)	2.22172982
42	Hypothermia (HP:0002045)	2.21809106
43	Polyuria (HP:0000103)	2.21507833
44	Chorioretinal atrophy (HP:0000533)	2.20449023
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.18895601
46	Progressive macrocephaly (HP:0004481)	2.17909265
47	Gait imbalance (HP:0002141)	2.16966640
48	Acute encephalopathy (HP:0006846)	2.16486228
49	Postaxial foot polydactyly (HP:0001830)	2.15843497
50	Large for gestational age (HP:0001520)	2.15698627
51	Lissencephaly (HP:0001339)	2.14332834
52	Increased CSF lactate (HP:0002490)	2.13867222
53	Furrowed tongue (HP:0000221)	2.12286279
54	Cerebellar dysplasia (HP:0007033)	2.10717385
55	Hyperglycinemia (HP:0002154)	2.10532520
56	Progressive inability to walk (HP:0002505)	2.09531540
57	Congenital primary aphakia (HP:0007707)	2.08886108
58	Aplasia/hypoplasia of the uterus (HP:0008684)	2.08151216
59	Broad-based gait (HP:0002136)	2.07757010
60	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.06336612
61	Male pseudohermaphroditism (HP:0000037)	2.05913556
62	Congenital hepatic fibrosis (HP:0002612)	2.04938416
63	Bony spicule pigmentary retinopathy (HP:0007737)	2.04250914
64	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.03987435
65	Optic nerve hypoplasia (HP:0000609)	2.02696254
66	3-Methylglutaconic aciduria (HP:0003535)	2.02014647
67	Congenital sensorineural hearing impairment (HP:0008527)	2.01138732
68	Retinal dysplasia (HP:0007973)	2.00050434
69	Renal cortical cysts (HP:0000803)	1.99348524
70	Optic disc pallor (HP:0000543)	1.99244197
71	Abnormal mitochondria in muscle tissue (HP:0008316)	1.97941547
72	Hypoplasia of the uterus (HP:0000013)	1.97329551
73	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.96756679
74	Nephrogenic diabetes insipidus (HP:0009806)	1.96459634
75	Lipid accumulation in hepatocytes (HP:0006561)	1.93756876
76	Abnormality of the labia minora (HP:0012880)	1.93473281
77	Genital tract atresia (HP:0001827)	1.91550621
78	Occipital encephalocele (HP:0002085)	1.89328611
79	Increased hepatocellular lipid droplets (HP:0006565)	1.88066281
80	Pachygyria (HP:0001302)	1.85565305
81	Abnormal ciliary motility (HP:0012262)	1.84098370
82	Abnormal urine output (HP:0012590)	1.82955515
83	Congenital, generalized hypertrichosis (HP:0004540)	1.79219458
84	Postaxial hand polydactyly (HP:0001162)	1.79141278
85	Abnormal biliary tract physiology (HP:0012439)	1.78786202
86	Bile duct proliferation (HP:0001408)	1.78786202
87	Hemiparesis (HP:0001269)	1.78243283
88	Intestinal atresia (HP:0011100)	1.77334197
89	Vaginal atresia (HP:0000148)	1.76733481
90	Aplasia/Hypoplasia of the patella (HP:0006498)	1.76075466
91	Short tibia (HP:0005736)	1.75347633
92	Hypomagnesemia (HP:0002917)	1.75224079
93	Severe muscular hypotonia (HP:0006829)	1.73109214
94	Patellar aplasia (HP:0006443)	1.71775448
95	Abnormality of urine glucose concentration (HP:0011016)	1.71050694
96	Glycosuria (HP:0003076)	1.71050694
97	Abnormal respiratory motile cilium physiology (HP:0012261)	1.69015998
98	Hepatocellular necrosis (HP:0001404)	1.68787358
99	Preaxial hand polydactyly (HP:0001177)	1.68738771
100	Ketosis (HP:0001946)	1.68633165

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.20300691
2	BMPR1B	3.67354029
3	ADRBK2	3.20230025
4	CASK	2.69387440
5	ZAK	2.60134924
6	INSRR	2.57623098
7	MAP4K2	2.56923151
8	GRK1	2.50103067
9	WNK3	2.39659409
10	TLK1	2.34002403
11	WNK4	2.31008620
12	PINK1	2.28323783
13	NUAK1	2.11354329
14	MAP3K4	1.87564875
15	MAPK13	1.65635159
16	TXK	1.65386746
17	PLK2	1.60645885
18	ACVR1B	1.57508825
19	OXSR1	1.54368499
20	STK39	1.47183513
21	PLK4	1.44364427
22	TNIK	1.40592153
23	MARK1	1.39474018
24	DYRK2	1.31251932
25	TGFBR1	1.27747712
26	TAOK3	1.18641382
27	PASK	1.17111051
28	MKNK2	1.16455612
29	PAK3	1.14736775
30	MAP2K7	1.07343305
31	NTRK3	1.06023972
32	PNCK	1.03023484
33	PRKCE	0.99886201
34	BCKDK	0.98837257
35	ADRBK1	0.97525745
36	VRK1	0.95073789
37	PRKCG	0.93658512
38	TRIM28	0.93272514
39	DAPK2	0.92146661
40	FGFR2	0.92136011
41	MAPKAPK3	0.86732439
42	NTRK2	0.85962601
43	CAMKK2	0.84187543
44	EPHA4	0.83792454
45	PHKG2	0.82822694
46	PHKG1	0.82822694
47	CDK8	0.82640424
48	CSNK1G2	0.81742509
49	TIE1	0.80310804
50	MST4	0.75763064
51	PTK2B	0.75338838
52	CSNK1G3	0.74563186
53	CSNK1G1	0.73338451
54	MAPK15	0.72850820
55	STK38L	0.72493628
56	TAF1	0.71124174
57	CAMK2A	0.68705261
58	RPS6KA5	0.65017490
59	CAMK1	0.63485592
60	KIT	0.63245856
61	ERBB3	0.62425526
62	IRAK1	0.62211547
63	PLK3	0.61296664
64	STK11	0.58604073
65	PRKCQ	0.57067614
66	STK16	0.56445817
67	NME1	0.55324761
68	PKN1	0.54877961
69	BCR	0.52719176
70	IKBKB	0.52169603
71	CSNK1A1L	0.51329173
72	PRKACA	0.51149711
73	CSNK1A1	0.50706171
74	MUSK	0.46934594
75	FER	0.46373266
76	MKNK1	0.44682535
77	FLT3	0.42964658
78	SIK2	0.42656660
79	MAP2K6	0.42194997
80	PIK3CA	0.41129885
81	EPHA3	0.40551723
82	PRKCA	0.39766720
83	PRKCZ	0.39644266
84	STK3	0.38269298
85	CHUK	0.37222679
86	MAPKAPK5	0.36677879
87	PRKG1	0.36626091
88	GRK7	0.34419533
89	OBSCN	0.34109574
90	RPS6KA4	0.34072750
91	TEC	0.33995375
92	CSNK1D	0.32955578
93	PRKCI	0.32922332
94	CAMKK1	0.32864233
95	PIK3CG	0.32293144
96	SGK223	0.32076720
97	SGK494	0.32076720
98	EPHB2	0.31903992
99	SGK2	0.31851386
100	PRKAA1	0.31841713

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	2.74139875
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.74127427
3	Phototransduction_Homo sapiens_hsa04744	2.60212759
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.39061698
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.35055414
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.34301976
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.33117909
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.30203062
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.29269043
10	Protein export_Homo sapiens_hsa03060	2.25716469
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.23023837
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.13811201
13	Butanoate metabolism_Homo sapiens_hsa00650	2.13382474
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.07238304
15	Nicotine addiction_Homo sapiens_hsa05033	1.93107232
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.82959993
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.82132582
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.81974165
19	Parkinsons disease_Homo sapiens_hsa05012	1.67331362
20	Basal transcription factors_Homo sapiens_hsa03022	1.64430311
21	RNA polymerase_Homo sapiens_hsa03020	1.64425393
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.59393429
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.58269612
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.56787056
25	Olfactory transduction_Homo sapiens_hsa04740	1.53862513
26	One carbon pool by folate_Homo sapiens_hsa00670	1.50394813
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.50029669
28	Homologous recombination_Homo sapiens_hsa03440	1.45875558
29	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.43540180
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.43182358
31	Propanoate metabolism_Homo sapiens_hsa00640	1.37477066
32	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.28235165
33	RNA degradation_Homo sapiens_hsa03018	1.26982070
34	Taste transduction_Homo sapiens_hsa04742	1.26785333
35	Morphine addiction_Homo sapiens_hsa05032	1.22130995
36	Cardiac muscle contraction_Homo sapiens_hsa04260	1.20331127
37	Huntingtons disease_Homo sapiens_hsa05016	1.18091513
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.15460010
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.07553544
40	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.06559202
41	Peroxisome_Homo sapiens_hsa04146	1.05696511
42	Collecting duct acid secretion_Homo sapiens_hsa04966	1.05583932
43	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.05399086
44	Retinol metabolism_Homo sapiens_hsa00830	1.05355831
45	Alzheimers disease_Homo sapiens_hsa05010	1.04327263
46	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.97101879
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.95237929
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94047431
49	Circadian entrainment_Homo sapiens_hsa04713	0.92677815
50	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.91438849
51	Serotonergic synapse_Homo sapiens_hsa04726	0.86686346
52	Insulin secretion_Homo sapiens_hsa04911	0.85813189
53	GABAergic synapse_Homo sapiens_hsa04727	0.85779279
54	Glutamatergic synapse_Homo sapiens_hsa04724	0.85434781
55	Asthma_Homo sapiens_hsa05310	0.84625557
56	ABC transporters_Homo sapiens_hsa02010	0.84447456
57	Sulfur metabolism_Homo sapiens_hsa00920	0.83459063
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.82975405
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.82809886
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.82382603
61	Regulation of autophagy_Homo sapiens_hsa04140	0.82281215
62	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.77562352
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71831556
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.71463260
65	Metabolic pathways_Homo sapiens_hsa01100	0.69060531
66	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.68413727
67	Sulfur relay system_Homo sapiens_hsa04122	0.67260364
68	Purine metabolism_Homo sapiens_hsa00230	0.67222881
69	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64939333
70	Proteasome_Homo sapiens_hsa03050	0.63923739
71	Type I diabetes mellitus_Homo sapiens_hsa04940	0.60881833
72	Steroid biosynthesis_Homo sapiens_hsa00100	0.60544582
73	Ribosome_Homo sapiens_hsa03010	0.59912559
74	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59396183
75	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.59138854
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.57318998
77	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.56434755
78	Histidine metabolism_Homo sapiens_hsa00340	0.55542544
79	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.55121091
80	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.54557495
81	Salivary secretion_Homo sapiens_hsa04970	0.52010638
82	Mineral absorption_Homo sapiens_hsa04978	0.49946678
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.49054723
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48957508
85	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.47928817
86	Dopaminergic synapse_Homo sapiens_hsa04728	0.47654463
87	Primary immunodeficiency_Homo sapiens_hsa05340	0.45465964
88	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.44758612
89	Allograft rejection_Homo sapiens_hsa05330	0.44164339
90	Non-homologous end-joining_Homo sapiens_hsa03450	0.43938172
91	Cocaine addiction_Homo sapiens_hsa05030	0.43439305
92	Fatty acid degradation_Homo sapiens_hsa00071	0.43223142
93	Pyrimidine metabolism_Homo sapiens_hsa00240	0.43184529
94	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.42342198
95	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.41793508
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.39685323
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39381908
98	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.39266703
99	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.39112000
100	Arginine and proline metabolism_Homo sapiens_hsa00330	0.38766585

FAM92A1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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