

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.49291265 |
| 2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.66700055 |
| 3 | ATP synthesis coupled proton transport (GO:0015986) | 5.66700055 |
| 4 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.01477108 |
| 5 | chaperone-mediated protein transport (GO:0072321) | 4.84763034 |
| 6 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.84206231 |
| 7 | ribosomal small subunit assembly (GO:0000028) | 4.79872268 |
| 8 | respiratory electron transport chain (GO:0022904) | 4.73420903 |
| 9 | electron transport chain (GO:0022900) | 4.62342350 |
| 10 | proteasome assembly (GO:0043248) | 4.22079054 |
| 11 | regulation of mitochondrial translation (GO:0070129) | 4.03317081 |
| 12 | DNA deamination (GO:0045006) | 3.97789281 |
| 13 | protein complex biogenesis (GO:0070271) | 3.93393865 |
| 14 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.91814633 |
| 15 | oxidative phosphorylation (GO:0006119) | 3.87799327 |
| 16 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.85089787 |
| 17 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.83448348 |
| 18 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.76601208 |
| 19 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.75451682 |
| 20 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.74219942 |
| 21 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.72821186 |
| 22 | NADH dehydrogenase complex assembly (GO:0010257) | 3.72821186 |
| 23 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.72821186 |
| 24 | protein neddylation (GO:0045116) | 3.72492750 |
| 25 | respiratory chain complex IV assembly (GO:0008535) | 3.70869073 |
| 26 | DNA strand elongation (GO:0022616) | 3.70140583 |
| 27 | formation of translation preinitiation complex (GO:0001731) | 3.64237590 |
| 28 | telomere maintenance via recombination (GO:0000722) | 3.62160338 |
| 29 | establishment of integrated proviral latency (GO:0075713) | 3.57453686 |
| 30 | viral transcription (GO:0019083) | 3.54425498 |
| 31 | protein targeting to mitochondrion (GO:0006626) | 3.53973746 |
| 32 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.53729246 |
| 33 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.50410851 |
| 34 | ribosomal small subunit biogenesis (GO:0042274) | 3.49534098 |
| 35 | cullin deneddylation (GO:0010388) | 3.47448614 |
| 36 | translational termination (GO:0006415) | 3.47225612 |
| 37 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.46337741 |
| 38 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.45422344 |
| 39 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.45218115 |
| 40 | cytochrome complex assembly (GO:0017004) | 3.42801159 |
| 41 | negative regulation of ligase activity (GO:0051352) | 3.39861242 |
| 42 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.39861242 |
| 43 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.39733686 |
| 44 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.39733686 |
| 45 | inner mitochondrial membrane organization (GO:0007007) | 3.39644547 |
| 46 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.38042829 |
| 47 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.38042829 |
| 48 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.38042829 |
| 49 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.35852113 |
| 50 | histone exchange (GO:0043486) | 3.33185859 |
| 51 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.32194133 |
| 52 | protein localization to mitochondrion (GO:0070585) | 3.28720308 |
| 53 | establishment of protein localization to mitochondrion (GO:0072655) | 3.28160802 |
| 54 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.27369324 |
| 55 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.27369324 |
| 56 | mitotic recombination (GO:0006312) | 3.27132058 |
| 57 | cotranslational protein targeting to membrane (GO:0006613) | 3.26974329 |
| 58 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.24861402 |
| 59 | ATP biosynthetic process (GO:0006754) | 3.24249076 |
| 60 | protein targeting to ER (GO:0045047) | 3.23384170 |
| 61 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.22449315 |
| 62 | purine nucleobase biosynthetic process (GO:0009113) | 3.20905615 |
| 63 | maturation of SSU-rRNA (GO:0030490) | 3.20745123 |
| 64 | ribosomal large subunit biogenesis (GO:0042273) | 3.20699183 |
| 65 | protein deneddylation (GO:0000338) | 3.19712293 |
| 66 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.19033771 |
| 67 | DNA replication initiation (GO:0006270) | 3.17708283 |
| 68 | neutrophil activation involved in immune response (GO:0002283) | 3.17664763 |
| 69 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.16096809 |
| 70 | protein localization to endoplasmic reticulum (GO:0070972) | 3.13831307 |
| 71 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.13077929 |
| 72 | translational elongation (GO:0006414) | 3.12951211 |
| 73 | CENP-A containing nucleosome assembly (GO:0034080) | 3.12655396 |
| 74 | DNA damage response, detection of DNA damage (GO:0042769) | 3.12232876 |
| 75 | nucleobase biosynthetic process (GO:0046112) | 3.06921518 |
| 76 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.05081667 |
| 77 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.04913435 |
| 78 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 3.04913382 |
| 79 | DNA ligation (GO:0006266) | 3.04671023 |
| 80 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.03848934 |
| 81 | translational initiation (GO:0006413) | 3.03124982 |
| 82 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.02186967 |
| 83 | DNA double-strand break processing (GO:0000729) | 3.02049886 |
| 84 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.01425200 |
| 85 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.00765898 |
| 86 | translation (GO:0006412) | 2.99776237 |
| 87 | hydrogen ion transmembrane transport (GO:1902600) | 2.99373435 |
| 88 | histone mRNA metabolic process (GO:0008334) | 2.98355198 |
| 89 | rRNA methylation (GO:0031167) | 2.97663878 |
| 90 | positive regulation of ligase activity (GO:0051351) | 2.94631870 |
| 91 | establishment of viral latency (GO:0019043) | 2.94494088 |
| 92 | mitochondrial transport (GO:0006839) | 2.93736755 |
| 93 | telomere maintenance via telomere lengthening (GO:0010833) | 2.93191734 |
| 94 | DNA replication checkpoint (GO:0000076) | 2.92101408 |
| 95 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.90996050 |
| 96 | chromatin remodeling at centromere (GO:0031055) | 2.89164090 |
| 97 | termination of RNA polymerase III transcription (GO:0006386) | 2.86328156 |
| 98 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.86328156 |
| 99 | cell cycle G1/S phase transition (GO:0044843) | 2.82894684 |
| 100 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.82894684 |
| 101 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 2.82331383 |
| 102 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.78345601 |
| 103 | positive regulation of cell cycle arrest (GO:0071158) | 2.74830505 |
| 104 | viral life cycle (GO:0019058) | 2.73510704 |
| 105 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.71488930 |
| 106 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 2.70216026 |
| 107 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 2.68364925 |
| 108 | kinetochore organization (GO:0051383) | 2.66927692 |
| 109 | ribosome assembly (GO:0042255) | 2.66474915 |
| 110 | rRNA processing (GO:0006364) | 2.66206388 |
| 111 | cellular protein complex disassembly (GO:0043624) | 2.65998842 |
| 112 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.65897936 |
| 113 | 7-methylguanosine mRNA capping (GO:0006370) | 2.65262969 |
| 114 | mitotic metaphase plate congression (GO:0007080) | 2.65132882 |
| 115 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.65105248 |
| 116 | RNA capping (GO:0036260) | 2.63975010 |
| 117 | 7-methylguanosine RNA capping (GO:0009452) | 2.63975010 |
| 118 | regulation of ligase activity (GO:0051340) | 2.60439681 |
| 119 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.59210047 |
| 120 | ribosome biogenesis (GO:0042254) | 2.58224065 |
| 121 | pseudouridine synthesis (GO:0001522) | 2.58015767 |
| 122 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.57045292 |
| 123 | DNA replication-independent nucleosome organization (GO:0034724) | 2.57045292 |
| 124 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.57022557 |
| 125 | rRNA modification (GO:0000154) | 2.55048474 |
| 126 | rRNA metabolic process (GO:0016072) | 2.54715431 |
| 127 | kinetochore assembly (GO:0051382) | 2.53849933 |
| 128 | viral mRNA export from host cell nucleus (GO:0046784) | 2.52496730 |
| 129 | respiratory burst (GO:0045730) | 2.48850675 |
| 130 | spliceosomal snRNP assembly (GO:0000387) | 2.47602455 |
| 131 | signal transduction in response to DNA damage (GO:0042770) | 2.46607969 |
| 132 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.46007570 |
| 133 | response to interferon-beta (GO:0035456) | 2.44316653 |
| 134 | regulation of cellular amine metabolic process (GO:0033238) | 2.44183907 |
| 135 | cellular component biogenesis (GO:0044085) | 2.43602353 |
| 136 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.42763564 |
| 137 | immunoglobulin mediated immune response (GO:0016064) | 2.42534516 |
| 138 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.42030753 |
| 139 | protein localization to kinetochore (GO:0034501) | 2.41599435 |
| 140 | metallo-sulfur cluster assembly (GO:0031163) | 2.41547130 |
| 141 | iron-sulfur cluster assembly (GO:0016226) | 2.41547130 |
| 142 | establishment of chromosome localization (GO:0051303) | 2.35575544 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.84305487 |
| 2 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.57342741 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.54401178 |
| 4 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.37279901 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.36601297 |
| 6 | * EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.16175475 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.04746980 |
| 8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.86578540 |
| 9 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.79242653 |
| 10 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.76253753 |
| 11 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.75547191 |
| 12 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.68727956 |
| 13 | * NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.62536470 |
| 14 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.52852761 |
| 15 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.48082605 |
| 16 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.42538207 |
| 17 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.37925990 |
| 18 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.37046234 |
| 19 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.36784906 |
| 20 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.35336371 |
| 21 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.30554804 |
| 22 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.23539010 |
| 23 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.10504796 |
| 24 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.10234256 |
| 25 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.08105420 |
| 26 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.06200417 |
| 27 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.05812891 |
| 28 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.01857534 |
| 29 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.00181044 |
| 30 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.97905605 |
| 31 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.97286726 |
| 32 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.95839414 |
| 33 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.94047385 |
| 34 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.93795512 |
| 35 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.93382472 |
| 36 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.93097506 |
| 37 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.93025822 |
| 38 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.86003483 |
| 39 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.81438775 |
| 40 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.75071937 |
| 41 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.72023572 |
| 42 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.70390415 |
| 43 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.68468596 |
| 44 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.64722869 |
| 45 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.64539438 |
| 46 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.63057620 |
| 47 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.59677246 |
| 48 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.58291987 |
| 49 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.53393109 |
| 50 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.52247653 |
| 51 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.51233470 |
| 52 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.49024070 |
| 53 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.48769968 |
| 54 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.48489759 |
| 55 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.46420702 |
| 56 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.43143362 |
| 57 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.41710943 |
| 58 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.36378148 |
| 59 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.34890398 |
| 60 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.32469708 |
| 61 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.27686332 |
| 62 | VDR_22108803_ChIP-Seq_LS180_Human | 1.25026320 |
| 63 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.24737481 |
| 64 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.23827590 |
| 65 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.23801702 |
| 66 | EWS_26573619_Chip-Seq_HEK293_Human | 1.21557169 |
| 67 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.20561776 |
| 68 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.18872858 |
| 69 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.18112997 |
| 70 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.17111021 |
| 71 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.15411394 |
| 72 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.14394623 |
| 73 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.13911181 |
| 74 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.13526116 |
| 75 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.11109651 |
| 76 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.10823449 |
| 77 | * IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.10390031 |
| 78 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 1.09619415 |
| 79 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.08626507 |
| 80 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.07972158 |
| 81 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.07577470 |
| 82 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.06939969 |
| 83 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.06496113 |
| 84 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.06470439 |
| 85 | * BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.05650983 |
| 86 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.04321891 |
| 87 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.03982123 |
| 88 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.03006801 |
| 89 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.02967909 |
| 90 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.00318057 |
| 91 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.00157993 |
| 92 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.00062744 |
| 93 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.98233978 |
| 94 | FUS_26573619_Chip-Seq_HEK293_Human | 0.97038310 |
| 95 | MYB_26560356_Chip-Seq_TH2_Human | 0.96523127 |
| 96 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.94790523 |
| 97 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.93462763 |
| 98 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.93127806 |
| 99 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.93100328 |
| 100 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.93030798 |
| 101 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.92126422 |
| 102 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.91309605 |
| 103 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.91262351 |
| 104 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 0.91007178 |
| 105 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 0.90782839 |
| 106 | * STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.90649592 |
| 107 | SCL_19346495_ChIP-Seq_HPC-7_Human | 0.90512724 |
| 108 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.89842453 |
| 109 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 0.89344142 |
| 110 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.89022634 |
| 111 | MYB_26560356_Chip-Seq_TH1_Human | 0.88061972 |
| 112 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.87024817 |
| 113 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.86854736 |
| 114 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.83693029 |
| 115 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.83233573 |
| 116 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.82906987 |
| 117 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.81044649 |
| 118 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.77186928 |
| 119 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.75776622 |
| 120 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.74333594 |
| 121 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.72549503 |
| 122 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.72185256 |
| 123 | AR_20517297_ChIP-Seq_VCAP_Human | 0.70558750 |
| 124 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.69459221 |
| 125 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.69226254 |
| 126 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.68987617 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 3.98788424 |
| 2 | MP0001835_abnormal_antigen_presentation | 3.32739761 |
| 3 | MP0009785_altered_susceptibility_to | 2.85615280 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 2.73221955 |
| 5 | MP0010094_abnormal_chromosome_stability | 2.68708464 |
| 6 | MP0003111_abnormal_nucleus_morphology | 2.61641782 |
| 7 | MP0002148_abnormal_hypersensitivity_rea | 2.50055609 |
| 8 | MP0008057_abnormal_DNA_replication | 2.49148233 |
| 9 | MP0006292_abnormal_olfactory_placode | 2.45318959 |
| 10 | MP0003186_abnormal_redox_activity | 2.42719281 |
| 11 | MP0003436_decreased_susceptibility_to | 2.41807183 |
| 12 | MP0002396_abnormal_hematopoietic_system | 2.40617942 |
| 13 | MP0003077_abnormal_cell_cycle | 2.40327633 |
| 14 | MP0003136_yellow_coat_color | 2.39764963 |
| 15 | MP0005671_abnormal_response_to | 2.28576503 |
| 16 | MP0009333_abnormal_splenocyte_physiolog | 2.25528835 |
| 17 | MP0009379_abnormal_foot_pigmentation | 2.22346641 |
| 18 | MP0005025_abnormal_response_to | 2.20214225 |
| 19 | MP0008058_abnormal_DNA_repair | 2.18575968 |
| 20 | MP0002139_abnormal_hepatobiliary_system | 2.14609195 |
| 21 | MP0005000_abnormal_immune_tolerance | 2.13947835 |
| 22 | MP0002419_abnormal_innate_immunity | 2.12718177 |
| 23 | MP0003724_increased_susceptibility_to | 2.07991148 |
| 24 | MP0003195_calcinosis | 2.06007849 |
| 25 | MP0006072_abnormal_retinal_apoptosis | 2.02411641 |
| 26 | MP0003806_abnormal_nucleotide_metabolis | 2.01005697 |
| 27 | MP0002452_abnormal_antigen_presenting | 1.95666817 |
| 28 | MP0002938_white_spotting | 1.94236885 |
| 29 | MP0001853_heart_inflammation | 1.89303467 |
| 30 | MP0001800_abnormal_humoral_immune | 1.87254002 |
| 31 | MP0000490_abnormal_crypts_of | 1.86460996 |
| 32 | MP0002723_abnormal_immune_serum | 1.85122886 |
| 33 | MP0000685_abnormal_immune_system | 1.83243753 |
| 34 | MP0002420_abnormal_adaptive_immunity | 1.82758683 |
| 35 | MP0001819_abnormal_immune_cell | 1.82680623 |
| 36 | MP0008877_abnormal_DNA_methylation | 1.78730678 |
| 37 | MP0008007_abnormal_cellular_replicative | 1.76451397 |
| 38 | MP0006082_CNS_inflammation | 1.75500726 |
| 39 | MP0008875_abnormal_xenobiotic_pharmacok | 1.73751124 |
| 40 | MP0002398_abnormal_bone_marrow | 1.72272929 |
| 41 | MP0001545_abnormal_hematopoietic_system | 1.71423560 |
| 42 | MP0005397_hematopoietic_system_phenotyp | 1.71423560 |
| 43 | MP0005084_abnormal_gallbladder_morpholo | 1.71172925 |
| 44 | MP0001529_abnormal_vocalization | 1.70396323 |
| 45 | MP0001293_anophthalmia | 1.68133349 |
| 46 | MP0003656_abnormal_erythrocyte_physiolo | 1.65748126 |
| 47 | MP0002102_abnormal_ear_morphology | 1.63338430 |
| 48 | MP0000689_abnormal_spleen_morphology | 1.59774697 |
| 49 | MP0003011_delayed_dark_adaptation | 1.58506641 |
| 50 | MP0009840_abnormal_foam_cell | 1.58329816 |
| 51 | MP0000716_abnormal_immune_system | 1.57167246 |
| 52 | MP0003763_abnormal_thymus_physiology | 1.56429335 |
| 53 | MP0002722_abnormal_immune_system | 1.52317871 |
| 54 | MP0005464_abnormal_platelet_physiology | 1.52137802 |
| 55 | MP0005058_abnormal_lysosome_morphology | 1.51196539 |
| 56 | MP0002405_respiratory_system_inflammati | 1.50150556 |
| 57 | MP0001790_abnormal_immune_system | 1.49904581 |
| 58 | MP0005387_immune_system_phenotype | 1.49904581 |
| 59 | MP0002429_abnormal_blood_cell | 1.49423470 |
| 60 | MP0006054_spinal_hemorrhage | 1.48913759 |
| 61 | MP0003941_abnormal_skin_development | 1.46630569 |
| 62 | MP0002006_tumorigenesis | 1.46212122 |
| 63 | MP0002090_abnormal_vision | 1.45954432 |
| 64 | MP0008932_abnormal_embryonic_tissue | 1.45579784 |
| 65 | MP0003718_maternal_effect | 1.42892064 |
| 66 | MP0005085_abnormal_gallbladder_physiolo | 1.41872037 |
| 67 | MP0008260_abnormal_autophagy | 1.41327530 |
| 68 | MP0005332_abnormal_amino_acid | 1.40501295 |
| 69 | MP0008995_early_reproductive_senescence | 1.39541347 |
| 70 | MP0002163_abnormal_gland_morphology | 1.38530075 |
| 71 | MP0001845_abnormal_inflammatory_respons | 1.37191576 |
| 72 | MP0002837_dystrophic_cardiac_calcinosis | 1.36240769 |
| 73 | MP0008469_abnormal_protein_level | 1.35620620 |
| 74 | MP0006036_abnormal_mitochondrial_physio | 1.33829831 |
| 75 | MP0002132_abnormal_respiratory_system | 1.31829694 |
| 76 | MP0002166_altered_tumor_susceptibility | 1.30362229 |
| 77 | MP0010155_abnormal_intestine_physiology | 1.30188221 |
| 78 | MP0005075_abnormal_melanosome_morpholog | 1.28123422 |
| 79 | MP0005365_abnormal_bile_salt | 1.27975888 |
| 80 | MP0003786_premature_aging | 1.27291421 |
| 81 | MP0000465_gastrointestinal_hemorrhage | 1.24074876 |
| 82 | MP0002019_abnormal_tumor_incidence | 1.23722591 |
| 83 | MP0000343_altered_response_to | 1.23693100 |
| 84 | MP0000858_altered_metastatic_potential | 1.22434921 |
| 85 | MP0004808_abnormal_hematopoietic_stem | 1.22034847 |
| 86 | MP0004147_increased_porphyrin_level | 1.18874582 |
| 87 | MP0001764_abnormal_homeostasis | 1.17386937 |
| 88 | MP0005379_endocrine/exocrine_gland_phen | 1.15041249 |
| 89 | MP0008789_abnormal_olfactory_epithelium | 1.13988558 |
| 90 | MP0005253_abnormal_eye_physiology | 1.12317344 |
| 91 | MP0000313_abnormal_cell_death | 1.10953062 |
| 92 | MP0004019_abnormal_vitamin_homeostasis | 1.08775713 |
| 93 | MP0001533_abnormal_skeleton_physiology | 1.05925482 |
| 94 | MP0010307_abnormal_tumor_latency | 1.04068213 |
| 95 | MP0002638_abnormal_pupillary_reflex | 1.03088063 |
| 96 | MP0000703_abnormal_thymus_morphology | 1.00450056 |
| 97 | MP0002277_abnormal_respiratory_mucosa | 0.99265999 |
| 98 | MP0001324_abnormal_eye_pigmentation | 0.97980743 |
| 99 | MP0002210_abnormal_sex_determination | 0.97479913 |
| 100 | MP0004782_abnormal_surfactant_physiolog | 0.97285304 |
| 101 | MP0001730_embryonic_growth_arrest | 0.96568537 |
| 102 | MP0009697_abnormal_copulation | 0.96421166 |
| 103 | MP0005408_hypopigmentation | 0.96332316 |
| 104 | MP0009764_decreased_sensitivity_to | 0.96265819 |
| 105 | MP0001929_abnormal_gametogenesis | 0.96083858 |
| 106 | MP0000350_abnormal_cell_proliferation | 0.95157016 |
| 107 | MP0005360_urolithiasis | 0.94198031 |
| 108 | MP0003448_altered_tumor_morphology | 0.93251155 |
| 109 | MP0003866_abnormal_defecation | 0.91202185 |
| 110 | MP0001666_abnormal_nutrient_absorption | 0.88335921 |
| 111 | MP0005174_abnormal_tail_pigmentation | 0.86311437 |
| 112 | MP0009763_increased_sensitivity_to | 0.83545154 |
| 113 | MP0004947_skin_inflammation | 0.82909382 |
| 114 | MP0001145_abnormal_male_reproductive | 0.82515738 |
| 115 | MP0003567_abnormal_fetal_cardiomyocyte | 0.82083929 |
| 116 | MP0008872_abnormal_physiological_respon | 0.81909300 |
| 117 | MP0003191_abnormal_cellular_cholesterol | 0.81796564 |
| 118 | MP0000653_abnormal_sex_gland | 0.81360994 |
| 119 | MP0006035_abnormal_mitochondrial_morpho | 0.80818796 |
| 120 | MP0001697_abnormal_embryo_size | 0.79752876 |
| 121 | MP0000358_abnormal_cell_content/ | 0.77902358 |
| 122 | MP0003221_abnormal_cardiomyocyte_apopto | 0.76700446 |
| 123 | MP0002160_abnormal_reproductive_system | 0.76435048 |
| 124 | MP0002234_abnormal_pharynx_morphology | 0.76317913 |
| 125 | MP0005551_abnormal_eye_electrophysiolog | 0.76266597 |
| 126 | MP0005389_reproductive_system_phenotype | 0.75130046 |
| 127 | MP0003890_abnormal_embryonic-extraembry | 0.74870336 |
| 128 | MP0003252_abnormal_bile_duct | 0.73552851 |
| 129 | MP0005319_abnormal_enzyme/_coenzyme | 0.73302020 |
| 130 | MP0001542_abnormal_bone_strength | 0.73110323 |
| 131 | MP0001873_stomach_inflammation | 0.72419263 |
| 132 | MP0001485_abnormal_pinna_reflex | 0.72306948 |
| 133 | MP0002095_abnormal_skin_pigmentation | 0.72130511 |
| 134 | MP0004142_abnormal_muscle_tone | 0.71967421 |
| 135 | MP0005266_abnormal_metabolism | 0.70963347 |
| 136 | MP0005451_abnormal_body_composition | 0.70513721 |
| 137 | MP0000647_abnormal_sebaceous_gland | 0.70138408 |
| 138 | MP0003646_muscle_fatigue | 0.70068624 |
| 139 | MP0005310_abnormal_salivary_gland | 0.70058181 |
| 140 | MP0005391_vision/eye_phenotype | 0.69856154 |
| 141 | MP0001119_abnormal_female_reproductive | 0.69828618 |
| 142 | MP0010352_gastrointestinal_tract_polyps | 0.69773560 |
| 143 | MP0000598_abnormal_liver_morphology | 0.69591215 |
| 144 | MP0005645_abnormal_hypothalamus_physiol | 0.69024601 |
| 145 | MP0009643_abnormal_urine_homeostasis | 0.66642428 |
| 146 | MP0003172_abnormal_lysosome_physiology | 0.65069672 |
| 147 | MP0002736_abnormal_nociception_after | 0.64778518 |
| 148 | MP0005171_absent_coat_pigmentation | 0.64775275 |
| 149 | MP0001984_abnormal_olfaction | 0.64496626 |
| 150 | MP0003121_genomic_imprinting | 0.64242724 |
| 151 | MP0008873_increased_physiological_sensi | 0.63943926 |
| 152 | MP0005394_taste/olfaction_phenotype | 0.63341990 |
| 153 | MP0005499_abnormal_olfactory_system | 0.63341990 |
| 154 | MP0000372_irregular_coat_pigmentation | 0.63122927 |
| 155 | MP0002080_prenatal_lethality | 0.62836055 |
| 156 | MP0004215_abnormal_myocardial_fiber | 0.62058742 |
| 157 | MP0005646_abnormal_pituitary_gland | 0.61553138 |
| 158 | MP0001727_abnormal_embryo_implantation | 0.61458786 |
| 159 | MP0005636_abnormal_mineral_homeostasis | 0.61125100 |
| 160 | MP0001919_abnormal_reproductive_system | 0.60775549 |
| 161 | MP0005410_abnormal_fertilization | 0.60468638 |
| 162 | MP0005376_homeostasis/metabolism_phenot | 0.59772160 |
| 163 | MP0002254_reproductive_system_inflammat | 0.58201761 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Progressive macrocephaly (HP:0004481) | 4.61980150 |
| 2 | Recurrent abscess formation (HP:0002722) | 4.10011886 |
| 3 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.00178470 |
| 4 | Cerebral edema (HP:0002181) | 3.95440106 |
| 5 | Abnormal number of erythroid precursors (HP:0012131) | 3.94904355 |
| 6 | Recurrent bacterial skin infections (HP:0005406) | 3.67693059 |
| 7 | Petechiae (HP:0000967) | 3.43561787 |
| 8 | Reticulocytopenia (HP:0001896) | 3.28122913 |
| 9 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.13504823 |
| 10 | Eczematoid dermatitis (HP:0000976) | 3.11525196 |
| 11 | Poor head control (HP:0002421) | 3.09452540 |
| 12 | Birth length less than 3rd percentile (HP:0003561) | 3.06260311 |
| 13 | Abnormality of macrophages (HP:0004311) | 3.06092372 |
| 14 | Vacuolated lymphocytes (HP:0001922) | 3.04130390 |
| 15 | IgM deficiency (HP:0002850) | 3.03124547 |
| 16 | Increased hepatocellular lipid droplets (HP:0006565) | 3.02016596 |
| 17 | Aplastic anemia (HP:0001915) | 2.95935823 |
| 18 | Type I transferrin isoform profile (HP:0003642) | 2.94009639 |
| 19 | Reduced antithrombin III activity (HP:0001976) | 2.88935373 |
| 20 | Hepatic necrosis (HP:0002605) | 2.87230573 |
| 21 | Thrombocytosis (HP:0001894) | 2.85748415 |
| 22 | Nausea (HP:0002018) | 2.84015159 |
| 23 | Exertional dyspnea (HP:0002875) | 2.81242928 |
| 24 | Lipid accumulation in hepatocytes (HP:0006561) | 2.80766454 |
| 25 | Lethargy (HP:0001254) | 2.74983853 |
| 26 | Hyperglycinemia (HP:0002154) | 2.73649772 |
| 27 | Exercise intolerance (HP:0003546) | 2.73461823 |
| 28 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.69682476 |
| 29 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.69682476 |
| 30 | Hepatocellular necrosis (HP:0001404) | 2.68672171 |
| 31 | Macrocytic anemia (HP:0001972) | 2.68117257 |
| 32 | Degeneration of anterior horn cells (HP:0002398) | 2.66551486 |
| 33 | Abnormality of the anterior horn cell (HP:0006802) | 2.66551486 |
| 34 | Abnormality of methionine metabolism (HP:0010901) | 2.66133873 |
| 35 | Methylmalonic acidemia (HP:0002912) | 2.65359795 |
| 36 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.64886054 |
| 37 | 3-Methylglutaconic aciduria (HP:0003535) | 2.64771342 |
| 38 | Leukodystrophy (HP:0002415) | 2.63662033 |
| 39 | Colon cancer (HP:0003003) | 2.62248669 |
| 40 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.61871780 |
| 41 | Methylmalonic aciduria (HP:0012120) | 2.57636127 |
| 42 | Mitochondrial inheritance (HP:0001427) | 2.57466248 |
| 43 | Optic disc pallor (HP:0000543) | 2.55527608 |
| 44 | Obstructive lung disease (HP:0006536) | 2.53268741 |
| 45 | Chronic obstructive pulmonary disease (HP:0006510) | 2.53268741 |
| 46 | Multiple enchondromatosis (HP:0005701) | 2.45859547 |
| 47 | Pallor (HP:0000980) | 2.45576174 |
| 48 | Increased CSF lactate (HP:0002490) | 2.44897780 |
| 49 | Oral leukoplakia (HP:0002745) | 2.43197506 |
| 50 | Increased serum lactate (HP:0002151) | 2.42747212 |
| 51 | Abnormality of serum amino acid levels (HP:0003112) | 2.41794413 |
| 52 | Rough bone trabeculation (HP:0100670) | 2.41488363 |
| 53 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.39446462 |
| 54 | Hepatosplenomegaly (HP:0001433) | 2.37048100 |
| 55 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.36507675 |
| 56 | Meckel diverticulum (HP:0002245) | 2.36171439 |
| 57 | Myositis (HP:0100614) | 2.35893744 |
| 58 | Recurrent skin infections (HP:0001581) | 2.35506822 |
| 59 | Breast hypoplasia (HP:0003187) | 2.35147380 |
| 60 | CNS demyelination (HP:0007305) | 2.34838757 |
| 61 | Abnormality of T cell physiology (HP:0011840) | 2.33679322 |
| 62 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.32920841 |
| 63 | Abnormality of urine glucose concentration (HP:0011016) | 2.32326732 |
| 64 | Agnosia (HP:0010524) | 2.32306432 |
| 65 | Increased intramyocellular lipid droplets (HP:0012240) | 2.31446561 |
| 66 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.29572232 |
| 67 | Mediastinal lymphadenopathy (HP:0100721) | 2.29043997 |
| 68 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.28972722 |
| 69 | Abnormality of alanine metabolism (HP:0010916) | 2.28972722 |
| 70 | Hyperalaninemia (HP:0003348) | 2.28972722 |
| 71 | Abnormality of renal resorption (HP:0011038) | 2.28392545 |
| 72 | Autoimmune thrombocytopenia (HP:0001973) | 2.27302734 |
| 73 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.25396174 |
| 74 | Renal Fanconi syndrome (HP:0001994) | 2.23040663 |
| 75 | Acute necrotizing encephalopathy (HP:0006965) | 2.21890902 |
| 76 | Abnormality of the ileum (HP:0001549) | 2.20411338 |
| 77 | IgG deficiency (HP:0004315) | 2.19989309 |
| 78 | Abnormality of the labia minora (HP:0012880) | 2.18571200 |
| 79 | Abnormal protein glycosylation (HP:0012346) | 2.17842969 |
| 80 | Abnormal glycosylation (HP:0012345) | 2.17842969 |
| 81 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.17842969 |
| 82 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.17842969 |
| 83 | Basal ganglia calcification (HP:0002135) | 2.17014233 |
| 84 | Abnormality of chromosome stability (HP:0003220) | 2.16544854 |
| 85 | Pustule (HP:0200039) | 2.16076283 |
| 86 | Chromsome breakage (HP:0040012) | 2.15756440 |
| 87 | Recurrent viral infections (HP:0004429) | 2.14813515 |
| 88 | Recurrent fungal infections (HP:0002841) | 2.14753796 |
| 89 | Prolonged neonatal jaundice (HP:0006579) | 2.14353397 |
| 90 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.14041815 |
| 91 | Dicarboxylic aciduria (HP:0003215) | 2.14041815 |
| 92 | Abnormality of the preputium (HP:0100587) | 2.12396687 |
| 93 | Granulocytopenia (HP:0001913) | 2.12324862 |
| 94 | Pancytopenia (HP:0001876) | 2.12299322 |
| 95 | Chronic otitis media (HP:0000389) | 2.09545510 |
| 96 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.09499658 |
| 97 | Congenital, generalized hypertrichosis (HP:0004540) | 2.08066846 |
| 98 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.07563286 |
| 99 | Increased muscle lipid content (HP:0009058) | 2.06273383 |
| 100 | Hyperglycinuria (HP:0003108) | 2.06140589 |
| 101 | Increased serum pyruvate (HP:0003542) | 2.05743800 |
| 102 | Abnormality of glycolysis (HP:0004366) | 2.05743800 |
| 103 | Bone marrow hypocellularity (HP:0005528) | 2.04975070 |
| 104 | Abnormality of T cells (HP:0002843) | 2.04338663 |
| 105 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.03578254 |
| 106 | Abnormality of glycine metabolism (HP:0010895) | 2.03578254 |
| 107 | Respiratory difficulties (HP:0002880) | 2.03253317 |
| 108 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.00472795 |
| 109 | Neutropenia (HP:0001875) | 1.99704972 |
| 110 | Megaloblastic anemia (HP:0001889) | 1.99631590 |
| 111 | Lymphoma (HP:0002665) | 1.99079276 |
| 112 | Cerebral hypomyelination (HP:0006808) | 1.97053940 |
| 113 | Purpura (HP:0000979) | 1.96273169 |
| 114 | Generalized aminoaciduria (HP:0002909) | 1.96182875 |
| 115 | Microretrognathia (HP:0000308) | 1.96092434 |
| 116 | Carpal bone hypoplasia (HP:0001498) | 1.94361945 |
| 117 | Abnormal trabecular bone morphology (HP:0100671) | 1.91548023 |
| 118 | Hyperphosphaturia (HP:0003109) | 1.91311891 |
| 119 | Eosinophilia (HP:0001880) | 1.90049739 |
| 120 | Acute encephalopathy (HP:0006846) | 1.88460400 |
| 121 | Meningitis (HP:0001287) | 1.88428053 |
| 122 | Hypoglycemic coma (HP:0001325) | 1.88254746 |
| 123 | Pancreatic cysts (HP:0001737) | 1.87608396 |
| 124 | Neoplasm of the adrenal gland (HP:0100631) | 1.87331777 |
| 125 | Recurrent pneumonia (HP:0006532) | 1.87256259 |
| 126 | Microcytic anemia (HP:0001935) | 1.87197030 |
| 127 | Premature graying of hair (HP:0002216) | 1.87102176 |
| 128 | Lactic acidosis (HP:0003128) | 1.86871834 |
| 129 | Abnormality of midbrain morphology (HP:0002418) | 1.85920787 |
| 130 | Molar tooth sign on MRI (HP:0002419) | 1.85920787 |
| 131 | Combined immunodeficiency (HP:0005387) | 1.84889569 |
| 132 | X-linked dominant inheritance (HP:0001423) | 1.83505154 |
| 133 | Vasculitis (HP:0002633) | 1.82399698 |
| 134 | Leukocytosis (HP:0001974) | 1.81924166 |
| 135 | Abnormality of eosinophils (HP:0001879) | 1.81356563 |
| 136 | Microvesicular hepatic steatosis (HP:0001414) | 1.80700318 |
| 137 | Cellulitis (HP:0100658) | 1.79492400 |
| 138 | Abnormality of the prostate (HP:0008775) | 1.77831004 |
| 139 | Urticaria (HP:0001025) | 1.77642555 |
| 140 | Respiratory failure (HP:0002878) | 1.77636490 |
| 141 | Myelodysplasia (HP:0002863) | 1.77480386 |
| 142 | Glycosuria (HP:0003076) | 1.77460326 |
| 143 | Triphalangeal thumb (HP:0001199) | 1.75154877 |
| 144 | Abnormal lung lobation (HP:0002101) | 1.73577942 |
| 145 | Abnormality of vitamin B metabolism (HP:0004340) | 1.70279088 |
| 146 | Pancreatic fibrosis (HP:0100732) | 1.69642029 |
| 147 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 1.69563949 |
| 148 | Medial flaring of the eyebrow (HP:0010747) | 1.68975473 |
| 149 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.67162306 |
| 150 | Cellular immunodeficiency (HP:0005374) | 1.65559443 |
| 151 | Duodenal stenosis (HP:0100867) | 1.65132597 |
| 152 | Small intestinal stenosis (HP:0012848) | 1.65132597 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.18348373 |
| 2 | VRK2 | 4.02070621 |
| 3 | STK16 | 3.49110619 |
| 4 | EIF2AK1 | 3.37717719 |
| 5 | NME2 | 3.36092914 |
| 6 | WEE1 | 3.22906423 |
| 7 | PIM2 | 2.70771112 |
| 8 | EIF2AK3 | 2.65361346 |
| 9 | PBK | 2.33303652 |
| 10 | MAP4K1 | 2.10477184 |
| 11 | PDK2 | 2.01972245 |
| 12 | IRAK4 | 2.01657233 |
| 13 | TRIM28 | 1.90498440 |
| 14 | BLK | 1.90209040 |
| 15 | BRSK2 | 1.89708200 |
| 16 | VRK1 | 1.77171242 |
| 17 | SRPK1 | 1.68619359 |
| 18 | IRAK3 | 1.65790655 |
| 19 | TESK2 | 1.65518514 |
| 20 | KDR | 1.60480106 |
| 21 | ACVR1B | 1.60063778 |
| 22 | CDC7 | 1.59619172 |
| 23 | PLK4 | 1.58733108 |
| 24 | BMPR1B | 1.58281927 |
| 25 | MST4 | 1.46398263 |
| 26 | TAF1 | 1.46140881 |
| 27 | MAP3K14 | 1.42406190 |
| 28 | TXK | 1.40254746 |
| 29 | MAP4K2 | 1.40112595 |
| 30 | KIT | 1.38994264 |
| 31 | WNK3 | 1.36343540 |
| 32 | TEC | 1.34948665 |
| 33 | ARAF | 1.34637366 |
| 34 | RPS6KA4 | 1.32541369 |
| 35 | TBK1 | 1.31239623 |
| 36 | ZAP70 | 1.31133405 |
| 37 | NEK2 | 1.30688771 |
| 38 | MKNK1 | 1.26421281 |
| 39 | EIF2AK2 | 1.22137510 |
| 40 | TYK2 | 1.21882505 |
| 41 | BTK | 1.21796637 |
| 42 | STK4 | 1.21515395 |
| 43 | PIM1 | 1.20733901 |
| 44 | NEK9 | 1.19168757 |
| 45 | IKBKB | 1.18919413 |
| 46 | DYRK3 | 1.15470361 |
| 47 | BCKDK | 1.11169707 |
| 48 | TSSK6 | 1.10589002 |
| 49 | ZAK | 1.10075479 |
| 50 | ABL2 | 1.06628685 |
| 51 | AURKB | 1.05873498 |
| 52 | DYRK2 | 1.03838212 |
| 53 | TESK1 | 1.01923919 |
| 54 | PLK1 | 1.00288205 |
| 55 | JAK3 | 0.99628555 |
| 56 | TLK1 | 0.98331000 |
| 57 | RPS6KB2 | 0.98037976 |
| 58 | MAP2K3 | 0.96128090 |
| 59 | IKBKE | 0.96010545 |
| 60 | BRSK1 | 0.94103039 |
| 61 | TNIK | 0.93384896 |
| 62 | LRRK2 | 0.93033832 |
| 63 | CDK19 | 0.92546581 |
| 64 | TTK | 0.89361923 |
| 65 | GRK1 | 0.88754018 |
| 66 | EPHA2 | 0.88494222 |
| 67 | CLK1 | 0.86803113 |
| 68 | ATR | 0.86261762 |
| 69 | CSNK1G3 | 0.86111924 |
| 70 | STK10 | 0.84929011 |
| 71 | CSF1R | 0.84601459 |
| 72 | CCNB1 | 0.84349470 |
| 73 | LYN | 0.84158044 |
| 74 | SYK | 0.83668176 |
| 75 | CSNK1G1 | 0.81162285 |
| 76 | CDK7 | 0.81054700 |
| 77 | INSRR | 0.77715130 |
| 78 | ERBB3 | 0.75996975 |
| 79 | NME1 | 0.75977200 |
| 80 | BCR | 0.74730603 |
| 81 | OXSR1 | 0.74480456 |
| 82 | MAP3K8 | 0.74305132 |
| 83 | MAP3K11 | 0.74101109 |
| 84 | PAK4 | 0.73183777 |
| 85 | AURKA | 0.70718772 |
| 86 | CDK4 | 0.65898608 |
| 87 | NUAK1 | 0.64974659 |
| 88 | CSNK1G2 | 0.64847346 |
| 89 | NEK1 | 0.64606324 |
| 90 | CSNK2A1 | 0.64075844 |
| 91 | BRAF | 0.64051829 |
| 92 | PLK3 | 0.63879189 |
| 93 | RPS6KA5 | 0.60848296 |
| 94 | SCYL2 | 0.59934122 |
| 95 | PASK | 0.59853577 |
| 96 | NLK | 0.59280143 |
| 97 | BMPR2 | 0.59235617 |
| 98 | DAPK1 | 0.57995490 |
| 99 | CSNK1A1L | 0.57900762 |
| 100 | TGFBR1 | 0.57884738 |
| 101 | PAK1 | 0.56939323 |
| 102 | ILK | 0.56537985 |
| 103 | MAP3K12 | 0.54120949 |
| 104 | STK3 | 0.53967711 |
| 105 | PLK2 | 0.53499975 |
| 106 | LCK | 0.53455276 |
| 107 | CHEK2 | 0.52507129 |
| 108 | MYLK | 0.50916717 |
| 109 | MKNK2 | 0.50846438 |
| 110 | ATM | 0.49314847 |
| 111 | PNCK | 0.49173843 |
| 112 | STK39 | 0.45747290 |
| 113 | CSNK2A2 | 0.45254698 |
| 114 | FLT3 | 0.45237239 |
| 115 | CDK8 | 0.44866913 |
| 116 | FRK | 0.44726062 |
| 117 | PRKCD | 0.44548527 |
| 118 | CHUK | 0.43945411 |
| 119 | LIMK1 | 0.43453337 |
| 120 | MARK3 | 0.40868579 |
| 121 | MAPKAPK2 | 0.38946645 |
| 122 | MAPKAPK5 | 0.36719394 |
| 123 | YES1 | 0.35667858 |
| 124 | DAPK3 | 0.34685273 |
| 125 | ALK | 0.32250878 |
| 126 | RPS6KA6 | 0.32204768 |
| 127 | GRK6 | 0.31906923 |
| 128 | ITK | 0.30919717 |
| 129 | OBSCN | 0.30794511 |
| 130 | TRPM7 | 0.30778397 |
| 131 | ADRBK2 | 0.30414849 |
| 132 | MAP3K4 | 0.30009654 |
| 133 | MAP2K7 | 0.29865602 |
| 134 | WNK4 | 0.29716687 |
| 135 | CHEK1 | 0.29644353 |
| 136 | PRKCG | 0.29348098 |
| 137 | CSNK1E | 0.26923733 |
| 138 | MATK | 0.26144340 |
| 139 | CDK3 | 0.25958775 |
| 140 | CSNK1A1 | 0.25453075 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.40945803 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 3.82140857 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 3.63792275 |
| 4 | Mismatch repair_Homo sapiens_hsa03430 | 2.94935338 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.89683287 |
| 6 | Homologous recombination_Homo sapiens_hsa03440 | 2.31004822 |
| 7 | Base excision repair_Homo sapiens_hsa03410 | 2.29750825 |
| 8 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.26268229 |
| 9 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.25247496 |
| 10 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.25245371 |
| 11 | Spliceosome_Homo sapiens_hsa03040 | 2.12165572 |
| 12 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.07930455 |
| 13 | Protein export_Homo sapiens_hsa03060 | 1.94375204 |
| 14 | RNA transport_Homo sapiens_hsa03013 | 1.70825848 |
| 15 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.61014435 |
| 16 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.52907649 |
| 17 | Legionellosis_Homo sapiens_hsa05134 | 1.48399158 |
| 18 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.48030102 |
| 19 | Cell cycle_Homo sapiens_hsa04110 | 1.44391226 |
| 20 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.43313233 |
| 21 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.41500757 |
| 22 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.41046794 |
| 23 | Parkinsons disease_Homo sapiens_hsa05012 | 1.37368875 |
| 24 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.37283267 |
| 25 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.35901826 |
| 26 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.35630281 |
| 27 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.32333656 |
| 28 | Basal transcription factors_Homo sapiens_hsa03022 | 1.25463054 |
| 29 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.24112570 |
| 30 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.22881043 |
| 31 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.20569746 |
| 32 | Allograft rejection_Homo sapiens_hsa05330 | 1.19911482 |
| 33 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.19345820 |
| 34 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.17388323 |
| 35 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.16023316 |
| 36 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.13714235 |
| 37 | Purine metabolism_Homo sapiens_hsa00230 | 1.11763786 |
| 38 | Leishmaniasis_Homo sapiens_hsa05140 | 1.11743009 |
| 39 | RNA degradation_Homo sapiens_hsa03018 | 1.09023482 |
| 40 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.08990480 |
| 41 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.08878918 |
| 42 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.05044256 |
| 43 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.04933122 |
| 44 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.04626569 |
| 45 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.01347366 |
| 46 | Huntingtons disease_Homo sapiens_hsa05016 | 1.00811275 |
| 47 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.00319671 |
| 48 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.00196572 |
| 49 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.99945662 |
| 50 | Asthma_Homo sapiens_hsa05310 | 0.99330865 |
| 51 | Measles_Homo sapiens_hsa05162 | 0.99320964 |
| 52 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.98901965 |
| 53 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.98578680 |
| 54 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.96274353 |
| 55 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.91696809 |
| 56 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.90100643 |
| 57 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.89264352 |
| 58 | Other glycan degradation_Homo sapiens_hsa00511 | 0.87093261 |
| 59 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.86360564 |
| 60 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.82553064 |
| 61 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.81074724 |
| 62 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.81039320 |
| 63 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.80782758 |
| 64 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.77743836 |
| 65 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.77407621 |
| 66 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.74780600 |
| 67 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.72412970 |
| 68 | Shigellosis_Homo sapiens_hsa05131 | 0.71796403 |
| 69 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.71699714 |
| 70 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.71629739 |
| 71 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.71275796 |
| 72 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.71249523 |
| 73 | Pertussis_Homo sapiens_hsa05133 | 0.70574627 |
| 74 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.69258133 |
| 75 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.68232012 |
| 76 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.68090762 |
| 77 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.67443790 |
| 78 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.66922139 |
| 79 | Alzheimers disease_Homo sapiens_hsa05010 | 0.65453620 |
| 80 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.65010142 |
| 81 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.64296217 |
| 82 | Malaria_Homo sapiens_hsa05144 | 0.63681457 |
| 83 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.63405755 |
| 84 | Retinol metabolism_Homo sapiens_hsa00830 | 0.63240592 |
| 85 | Lysosome_Homo sapiens_hsa04142 | 0.62793474 |
| 86 | Apoptosis_Homo sapiens_hsa04210 | 0.62763915 |
| 87 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.61955169 |
| 88 | Sulfur relay system_Homo sapiens_hsa04122 | 0.61649128 |
| 89 | Carbon metabolism_Homo sapiens_hsa01200 | 0.61436972 |
| 90 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.61305558 |
| 91 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.61073052 |
| 92 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.60245369 |
| 93 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.56925225 |
| 94 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.56661198 |
| 95 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.56125059 |
| 96 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.55531956 |
| 97 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.54891970 |
| 98 | Influenza A_Homo sapiens_hsa05164 | 0.54716739 |
| 99 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.54580487 |
| 100 | Tuberculosis_Homo sapiens_hsa05152 | 0.52804468 |
| 101 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.51897831 |
| 102 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.51728193 |
| 103 | Galactose metabolism_Homo sapiens_hsa00052 | 0.51052943 |
| 104 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.49807816 |
| 105 | Metabolic pathways_Homo sapiens_hsa01100 | 0.49766052 |
| 106 | Salmonella infection_Homo sapiens_hsa05132 | 0.49444658 |
| 107 | Phagosome_Homo sapiens_hsa04145 | 0.48852085 |
| 108 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.48535164 |
| 109 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.47771232 |
| 110 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.47683516 |
| 111 | Peroxisome_Homo sapiens_hsa04146 | 0.46835023 |
| 112 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.46345544 |
| 113 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.46209434 |
| 114 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.44139924 |
| 115 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.44108692 |
| 116 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.43958562 |
| 117 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.42544791 |
| 118 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.42292209 |
| 119 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.39104517 |
| 120 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.38348250 |
| 121 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.37778441 |
| 122 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.37391386 |
| 123 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.37300501 |
| 124 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.36334288 |
| 125 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.35074745 |
| 126 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.33435915 |
| 127 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.33395569 |
| 128 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.33197844 |
| 129 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.31778566 |
| 130 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.27698129 |
| 131 | Phototransduction_Homo sapiens_hsa04744 | 0.23657429 |

