ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of RIG-I signaling pathway (GO:0039535)	9.82654760
2	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	8.53194352
3	negative regulation of thymocyte apoptotic process (GO:0070244)	5.17367107
4	rRNA methylation (GO:0031167)	4.97132305
5	negative regulation of T cell apoptotic process (GO:0070233)	4.80820905
6	kynurenine metabolic process (GO:0070189)	4.78899516
7	negative regulation of calcium ion transport into cytosol (GO:0010523)	4.74372242
8	purine nucleotide salvage (GO:0032261)	4.55672295
9	tryptophan metabolic process (GO:0006568)	4.54883223
10	thrombin receptor signaling pathway (GO:0070493)	4.52652243
11	rRNA modification (GO:0000154)	4.42688283
12	nucleotide salvage (GO:0043173)	4.40481517
13	hemoglobin metabolic process (GO:0020027)	4.30007758
14	regulation of response to osmotic stress (GO:0047484)	4.20919454
15	rRNA catabolic process (GO:0016075)	4.19946964
16	phosphatidylglycerol biosynthetic process (GO:0006655)	4.18884384
17	cardiolipin metabolic process (GO:0032048)	4.16659490
18	positive regulation of histone H3-K4 methylation (GO:0051571)	3.91439339
19	indolalkylamine catabolic process (GO:0046218)	3.82091946
20	tryptophan catabolic process (GO:0006569)	3.82091946
21	indole-containing compound catabolic process (GO:0042436)	3.82091946
22	nucleoside salvage (GO:0043174)	3.79315936
23	AMP metabolic process (GO:0046033)	3.79187982
24	DNA strand renaturation (GO:0000733)	3.70346482
25	ADP metabolic process (GO:0046031)	3.69714345
26	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.68454297
27	positive regulation by host of viral transcription (GO:0043923)	3.64458879
28	negative regulation of lymphocyte apoptotic process (GO:0070229)	3.57638780
29	ribosome assembly (GO:0042255)	3.49692379
30	IMP biosynthetic process (GO:0006188)	3.49312446
31	regulation of histone H3-K27 methylation (GO:0061085)	3.49076939
32	replication fork processing (GO:0031297)	3.48885828
33	GMP metabolic process (GO:0046037)	3.47249275
34	ribonucleoside diphosphate metabolic process (GO:0009185)	3.46117381
35	viral mRNA export from host cell nucleus (GO:0046784)	3.45341656
36	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.43664754
37	intra-S DNA damage checkpoint (GO:0031573)	3.41517875
38	purine nucleobase biosynthetic process (GO:0009113)	3.33054485
39	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.30279879
40	positive regulation of gamma-delta T cell activation (GO:0046645)	3.30184039
41	cellular hyperosmotic response (GO:0071474)	3.30137488
42	organelle disassembly (GO:1903008)	3.25941488
43	pyrimidine nucleotide catabolic process (GO:0006244)	3.23029436
44	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.20133320
45	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.19756643
46	positive regulation of interleukin-8 secretion (GO:2000484)	3.19270174
47	import into cell (GO:0098657)	3.19168739
48	nucleoside diphosphate biosynthetic process (GO:0009133)	3.16986701
49	telomere maintenance via semi-conservative replication (GO:0032201)	3.14622439
50	regulation of superoxide anion generation (GO:0032928)	3.10760475
51	regulation of interleukin-8 secretion (GO:2000482)	3.09410962
52	positive regulation of alpha-beta T cell proliferation (GO:0046641)	3.08286581
53	positive regulation of histone methylation (GO:0031062)	3.07677417
54	IMP metabolic process (GO:0046040)	3.07645049
55	NIK/NF-kappaB signaling (GO:0038061)	3.07613954
56	regulation of thymocyte apoptotic process (GO:0070243)	3.05045132
57	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.02131703
58	indolalkylamine metabolic process (GO:0006586)	2.98744820
59	mitotic G2 DNA damage checkpoint (GO:0007095)	2.98463122
60	negative regulation of myeloid cell apoptotic process (GO:0033033)	2.97016747
61	modulation by host of viral transcription (GO:0043921)	2.93997684
62	modulation by host of symbiont transcription (GO:0052472)	2.93997684
63	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	2.90664090
64	regulation of natural killer cell mediated immunity (GO:0002715)	2.90664090
65	necroptotic process (GO:0070266)	2.89827563
66	nucleoside diphosphate catabolic process (GO:0009134)	2.88694498
67	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.86366571
68	regulation of glomerular filtration (GO:0003093)	2.85034673
69	parturition (GO:0007567)	2.84703440
70	eye photoreceptor cell differentiation (GO:0001754)	2.83958548
71	photoreceptor cell differentiation (GO:0046530)	2.83958548
72	purine-containing compound salvage (GO:0043101)	2.81361706
73	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.80325501
74	inositol phosphate dephosphorylation (GO:0046855)	2.80325501
75	positive regulation of response to biotic stimulus (GO:0002833)	2.79410578
76	interferon-gamma secretion (GO:0072643)	2.77857404
77	purine nucleoside diphosphate metabolic process (GO:0009135)	2.77535000
78	purine ribonucleoside diphosphate metabolic process (GO:0009179)	2.77535000
79	DNA strand elongation involved in DNA replication (GO:0006271)	2.76815839
80	lysine catabolic process (GO:0006554)	2.76113076
81	lysine metabolic process (GO:0006553)	2.76113076
82	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.75538090
83	negative regulation of necroptotic process (GO:0060546)	2.74834673
84	modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)	2.73944873
85	nucleobase biosynthetic process (GO:0046112)	2.73685982
86	regulation of exit from mitosis (GO:0007096)	2.72968312
87	regulation of T cell apoptotic process (GO:0070232)	2.72223816
88	telomere maintenance via telomere lengthening (GO:0010833)	2.72199745
89	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.72076641
90	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.72016847
91	piRNA metabolic process (GO:0034587)	2.71942186
92	erythrocyte maturation (GO:0043249)	2.70367573
93	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.67929644
94	folic acid-containing compound biosynthetic process (GO:0009396)	2.66379190
95	maternal behavior (GO:0042711)	2.66352763
96	regulation of gamma-delta T cell differentiation (GO:0045586)	2.65234166
97	pyrimidine-containing compound salvage (GO:0008655)	2.64895778
98	pyrimidine nucleoside salvage (GO:0043097)	2.64895778
99	protein polyglutamylation (GO:0018095)	2.63479359
100	I-kappaB phosphorylation (GO:0007252)	2.59656188

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.91113711
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	5.62645899
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	4.61721202
4	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.82774317
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.72271037
6	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.61565194
7	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.21102011
8	MYC_22102868_ChIP-Seq_BL_Human	2.85662766
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.70670263
10	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.70092567
11	MYB_26560356_Chip-Seq_TH2_Human	2.50567599
12	ZNF263_19887448_ChIP-Seq_K562_Human	2.45647213
13	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.42934216
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.38989188
15	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.38147852
16	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.26609571
17	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.23138097
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.21801294
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.14406707
20	MYB_26560356_Chip-Seq_TH1_Human	1.94695910
21	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.84954783
22	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.74938190
23	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.73327947
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.69679627
25	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.68536795
26	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.67134436
27	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.66773640
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.66320381
29	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.64532512
30	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.60239801
31	CIITA_25753668_ChIP-Seq_RAJI_Human	1.58237766
32	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.57834882
33	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.51243078
34	GATA3_26560356_Chip-Seq_TH2_Human	1.51225712
35	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.51154464
36	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.50928472
37	KDM5A_27292631_Chip-Seq_BREAST_Human	1.47902140
38	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.46571448
39	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.45910842
40	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.41575936
41	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.41078846
42	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.37236051
43	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.36188866
44	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.35873925
45	VDR_23849224_ChIP-Seq_CD4+_Human	1.33226895
46	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.29952860
47	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.28990991
48	DCP1A_22483619_ChIP-Seq_HELA_Human	1.28194774
49	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.27001993
50	SPI1_23547873_ChIP-Seq_NB4_Human	1.26816341
51	GATA3_27048872_Chip-Seq_THYMUS_Human	1.24236648
52	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.21494783
53	MAF_26560356_Chip-Seq_TH2_Human	1.17898839
54	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.17749170
55	RUNX_20019798_ChIP-Seq_JUKART_Human	1.16798638
56	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16482763
57	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.14013971
58	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.12599340
59	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.08330477
60	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.07748149
61	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.06856404
62	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.04977580
63	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.04862929
64	MAF_26560356_Chip-Seq_TH1_Human	1.02850800
65	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.02492816
66	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.01126617
67	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.99780309
68	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.98744046
69	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.98663274
70	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.98662438
71	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.98283997
72	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.98101833
73	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.97765893
74	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.94804098
75	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.94442418
76	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.93854137
77	ELK1_19687146_ChIP-ChIP_HELA_Human	0.93279129
78	IRF8_27001747_Chip-Seq_BMDM_Mouse	0.91455621
79	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.90945921
80	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.88612716
81	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.87818011
82	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.87362737
83	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.86641730
84	IRF1_19129219_ChIP-ChIP_H3396_Human	0.86206930
85	XRN2_22483619_ChIP-Seq_HELA_Human	0.82462361
86	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.82360447
87	TTF2_22483619_ChIP-Seq_HELA_Human	0.82354193
88	GATA1_22025678_ChIP-Seq_K562_Human	0.82111265
89	VDR_21846776_ChIP-Seq_THP-1_Human	0.81726332
90	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.81713805
91	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.81610405
92	GABP_19822575_ChIP-Seq_HepG2_Human	0.81123166
93	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.80105338
94	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	0.78791668
95	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.77792425
96	UTX_26944678_Chip-Seq_JUKART_Human	0.77307174
97	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.76749942
98	RUNX1_22412390_ChIP-Seq_EML_Mouse	0.76639870
99	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.74004906
100	VDR_22108803_ChIP-Seq_LS180_Human	0.73908196

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002396_abnormal_hematopoietic_system	4.69987866
2	MP0003787_abnormal_imprinting	3.75732810
3	MP0009379_abnormal_foot_pigmentation	3.36006117
4	MP0005671_abnormal_response_to	3.21355073
5	MP0003806_abnormal_nucleotide_metabolis	3.12653882
6	MP0001188_hyperpigmentation	3.06989696
7	MP0010094_abnormal_chromosome_stability	2.95394914
8	MP0001835_abnormal_antigen_presentation	2.70012605
9	MP0000383_abnormal_hair_follicle	2.65674413
10	MP0003763_abnormal_thymus_physiology	2.46910140
11	MP0009333_abnormal_splenocyte_physiolog	2.32550452
12	MP0001800_abnormal_humoral_immune	2.31428668
13	MP0008058_abnormal_DNA_repair	2.26814952
14	MP0010678_abnormal_skin_adnexa	2.19371467
15	MP0005387_immune_system_phenotype	2.10281190
16	MP0001790_abnormal_immune_system	2.10281190
17	MP0002006_tumorigenesis	2.01035266
18	MP0002877_abnormal_melanocyte_morpholog	1.98141058
19	MP0008007_abnormal_cellular_replicative	1.92817057
20	MP0000685_abnormal_immune_system	1.87543324
21	MP0003075_altered_response_to	1.83342929
22	MP0005000_abnormal_immune_tolerance	1.81053780
23	MP0002160_abnormal_reproductive_system	1.79544036
24	MP0002723_abnormal_immune_serum	1.79522875
25	MP0001986_abnormal_taste_sensitivity	1.69630199
26	MP0002398_abnormal_bone_marrow	1.67952351
27	MP0006082_CNS_inflammation	1.64162845
28	MP0002420_abnormal_adaptive_immunity	1.63015411
29	MP0003111_abnormal_nucleus_morphology	1.61032485
30	MP0004147_increased_porphyrin_level	1.56916454
31	MP0002452_abnormal_antigen_presenting	1.54944495
32	MP0001819_abnormal_immune_cell	1.54502764
33	MP0003121_genomic_imprinting	1.54492048
34	MP0005464_abnormal_platelet_physiology	1.52929767
35	MP0002166_altered_tumor_susceptibility	1.52639277
36	MP0002405_respiratory_system_inflammati	1.50652356
37	MP0003252_abnormal_bile_duct	1.48915940
38	MP0000716_abnormal_immune_system	1.44415941
39	MP0005165_increased_susceptibility_to	1.41558769
40	MP0003718_maternal_effect	1.40318593
41	MP0005409_darkened_coat_color	1.37705625
42	MP0000689_abnormal_spleen_morphology	1.36266276
43	MP0003077_abnormal_cell_cycle	1.35376390
44	MP0005025_abnormal_response_to	1.32759040
45	MP0002429_abnormal_blood_cell	1.31836374
46	MP0002019_abnormal_tumor_incidence	1.31178914
47	MP0001881_abnormal_mammary_gland	1.30490410
48	MP0003941_abnormal_skin_development	1.28399586
49	MP0000015_abnormal_ear_pigmentation	1.27555483
50	MP0002722_abnormal_immune_system	1.27544475
51	MP0005174_abnormal_tail_pigmentation	1.26895520
52	MP0000703_abnormal_thymus_morphology	1.24581484
53	MP0001853_heart_inflammation	1.20834904
54	MP0002148_abnormal_hypersensitivity_rea	1.17978254
55	MP0005389_reproductive_system_phenotype	1.15636769
56	MP0008469_abnormal_protein_level	1.13084311
57	MP0004381_abnormal_hair_follicle	1.12095033
58	MP0008057_abnormal_DNA_replication	1.11360929
59	MP0010155_abnormal_intestine_physiology	1.11172690
60	MP0004808_abnormal_hematopoietic_stem	1.09093025
61	MP0001873_stomach_inflammation	1.08115222
62	MP0001845_abnormal_inflammatory_respons	1.07696464
63	MP0008875_abnormal_xenobiotic_pharmacok	1.06537542
64	MP0003693_abnormal_embryo_hatching	1.06210880
65	MP0003183_abnormal_peptide_metabolism	1.05443215
66	MP0009765_abnormal_xenobiotic_induced	1.05246158
67	MP0001730_embryonic_growth_arrest	1.01158294
68	MP0005451_abnormal_body_composition	0.99956719
69	MP0009785_altered_susceptibility_to	0.97618841
70	MP0003646_muscle_fatigue	0.94327061
71	MP0010234_abnormal_vibrissa_follicle	0.92848355
72	MP0005501_abnormal_skin_physiology	0.92268189
73	MP0005397_hematopoietic_system_phenotyp	0.92116187
74	MP0001545_abnormal_hematopoietic_system	0.92116187
75	MP0002933_joint_inflammation	0.91380146
76	MP0002138_abnormal_hepatobiliary_system	0.90799198
77	MP0002095_abnormal_skin_pigmentation	0.90703262
78	MP0003567_abnormal_fetal_cardiomyocyte	0.89729597
79	MP0003436_decreased_susceptibility_to	0.88293901
80	MP0000627_abnormal_mammary_gland	0.87102885
81	MP0003786_premature_aging	0.87015028
82	MP0002796_impaired_skin_barrier	0.85425668
83	MP0005075_abnormal_melanosome_morpholog	0.84857874
84	MP0003866_abnormal_defecation	0.84343642
85	MP0000609_abnormal_liver_physiology	0.83940643
86	MP0004782_abnormal_surfactant_physiolog	0.82913830
87	MP0005645_abnormal_hypothalamus_physiol	0.82508689
88	MP0005395_other_phenotype	0.81674040
89	MP0004957_abnormal_blastocyst_morpholog	0.75676755
90	MP0005410_abnormal_fertilization	0.73125797
91	MP0006036_abnormal_mitochondrial_physio	0.73092474
92	MP0005310_abnormal_salivary_gland	0.73060475
93	MP0009763_increased_sensitivity_to	0.72593369
94	MP0010771_integument_phenotype	0.69466067
95	MP0001502_abnormal_circadian_rhythm	0.69261035
96	MP0002419_abnormal_innate_immunity	0.67303694
97	MP0000350_abnormal_cell_proliferation	0.65738319
98	MP0009764_decreased_sensitivity_to	0.65726046
99	MP0001216_abnormal_epidermal_layer	0.65587475
100	MP0004484_altered_response_of	0.64645050

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal delayed hypersensitivity skin test (HP:0002963)	6.11172295
2	Abnormality of lateral ventricle (HP:0030047)	4.73601324
3	IgM deficiency (HP:0002850)	4.37470662
4	Slow saccadic eye movements (HP:0000514)	4.18235427
5	Agammaglobulinemia (HP:0004432)	4.13705036
6	Abnormality of T cell physiology (HP:0011840)	4.10445960
7	Autoimmune hemolytic anemia (HP:0001890)	4.07898692
8	Chronic mucocutaneous candidiasis (HP:0002728)	4.04492072
9	Recurrent cutaneous fungal infections (HP:0011370)	4.04492072
10	Panhypogammaglobulinemia (HP:0003139)	3.82142954
11	Elevated erythrocyte sedimentation rate (HP:0003565)	3.56727653
12	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.37987457
13	Abnormality of T cells (HP:0002843)	3.32632254
14	Chromsome breakage (HP:0040012)	3.31956366
15	Acute lymphatic leukemia (HP:0006721)	3.21309743
16	Colitis (HP:0002583)	3.20274481
17	Fatigue (HP:0012378)	3.19433921
18	Abnormality of T cell number (HP:0011839)	3.17550437
19	Recurrent viral infections (HP:0004429)	3.10109348
20	Abolished electroretinogram (ERG) (HP:0000550)	3.06848872
21	Mesangial abnormality (HP:0001966)	3.02074403
22	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.96152052
23	Aplastic anemia (HP:0001915)	2.94551004
24	Abnormality of the fingertips (HP:0001211)	2.94505452
25	Autoimmune thrombocytopenia (HP:0001973)	2.79639725
26	Abnormality of the prostate (HP:0008775)	2.79010950
27	T lymphocytopenia (HP:0005403)	2.75555069
28	Abnormality of chromosome stability (HP:0003220)	2.73448696
29	Encephalitis (HP:0002383)	2.66827380
30	Prostate neoplasm (HP:0100787)	2.64441760
31	Tubular atrophy (HP:0000092)	2.59077528
32	High pitched voice (HP:0001620)	2.58759127
33	Azoospermia (HP:0000027)	2.56542792
34	Anteriorly placed anus (HP:0001545)	2.52087752
35	Recurrent fungal infections (HP:0002841)	2.48722634
36	Abnormality of B cell number (HP:0010975)	2.48148741
37	Meningitis (HP:0001287)	2.47945090
38	Abnormality of the labia minora (HP:0012880)	2.40348913
39	Multiple enchondromatosis (HP:0005701)	2.39285827
40	Abnormality of saccadic eye movements (HP:0000570)	2.37098134
41	Prominent nose (HP:0000448)	2.36259413
42	Mediastinal lymphadenopathy (HP:0100721)	2.35460461
43	Dicarboxylic aciduria (HP:0003215)	2.32719275
44	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.32719275
45	Recurrent skin infections (HP:0001581)	2.32623210
46	Pustule (HP:0200039)	2.29119058
47	Acute myeloid leukemia (HP:0004808)	2.28971321
48	Abnormal rod and cone electroretinograms (HP:0008323)	2.27567205
49	IgG deficiency (HP:0004315)	2.24437590
50	Squamous cell carcinoma (HP:0002860)	2.22484411
51	Malignant hyperthermia (HP:0002047)	2.21379328
52	Inflammation of the large intestine (HP:0002037)	2.19859795
53	Diastasis recti (HP:0001540)	2.18274025
54	Onycholysis (HP:0001806)	2.16552116
55	Abnormality of cochlea (HP:0000375)	2.14288557
56	Muscle stiffness (HP:0003552)	2.13508949
57	Granulocytopenia (HP:0001913)	2.12940400
58	Abnormal spermatogenesis (HP:0008669)	2.12506310
59	3-Methylglutaconic aciduria (HP:0003535)	2.10831913
60	Papilledema (HP:0001085)	2.09158811
61	Severe combined immunodeficiency (HP:0004430)	2.07613430
62	Neoplasm of head and neck (HP:0012288)	2.07412079
63	Esophageal neoplasm (HP:0100751)	2.07412079
64	Microretrognathia (HP:0000308)	2.07403406
65	Selective tooth agenesis (HP:0001592)	2.07308111
66	Cone-rod dystrophy (HP:0000548)	2.07137765
67	Pigmentary retinal degeneration (HP:0001146)	2.03790247
68	Abnormality of the preputium (HP:0100587)	2.02959704
69	IgA deficiency (HP:0002720)	2.02906876
70	Genetic anticipation (HP:0003743)	2.02602348
71	Abnormality of methionine metabolism (HP:0010901)	2.00651719
72	Partial agenesis of the corpus callosum (HP:0001338)	1.98464904
73	Progressive muscle weakness (HP:0003323)	1.98376683
74	Abnormal number of incisors (HP:0011064)	1.98099775
75	Obstructive lung disease (HP:0006536)	1.97029683
76	Chronic obstructive pulmonary disease (HP:0006510)	1.97029683
77	Myelodysplasia (HP:0002863)	1.96326357
78	Tubulointerstitial fibrosis (HP:0005576)	1.96136466
79	Gastrointestinal inflammation (HP:0004386)	1.95681420
80	Lymphoma (HP:0002665)	1.95286066
81	Vasculitis (HP:0002633)	1.94433387
82	Decreased central vision (HP:0007663)	1.93364706
83	Duplicated collecting system (HP:0000081)	1.92552481
84	Dyschromatopsia (HP:0007641)	1.91159538
85	Intellectual disability, profound (HP:0002187)	1.90799137
86	Potter facies (HP:0002009)	1.88799825
87	Facial shape deformation (HP:0011334)	1.88799825
88	Conjunctival telangiectasia (HP:0000524)	1.87091478
89	Clubbing of toes (HP:0100760)	1.85546555
90	Macroorchidism (HP:0000053)	1.82608490
91	Gastrointestinal stroma tumor (HP:0100723)	1.80060058
92	Insulin-resistant diabetes mellitus (HP:0000831)	1.79778597
93	Hypoproteinemia (HP:0003075)	1.79063433
94	Constricted visual fields (HP:0001133)	1.77523753
95	Polydipsia (HP:0001959)	1.77476063
96	Abnormal drinking behavior (HP:0030082)	1.77476063
97	Tubulointerstitial abnormality (HP:0001969)	1.77449072
98	Abnormal biliary tract physiology (HP:0012439)	1.76918558
99	Bile duct proliferation (HP:0001408)	1.76918558
100	Anhidrosis (HP:0000970)	1.76500750

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	5.87987216
2	MAP4K1	4.70945065
3	MAP2K3	4.21788149
4	TXK	3.29583143
5	MAP3K14	3.16067390
6	MAP2K6	2.78461259
7	BCKDK	2.73341895
8	VRK1	2.57245255
9	FES	2.06037402
10	PASK	1.97400658
11	VRK2	1.95706833
12	TTK	1.95365693
13	CSF1R	1.87222008
14	KIT	1.78002720
15	TRPM7	1.76466867
16	RIPK4	1.69908904
17	JAK3	1.69002219
18	MATK	1.67204731
19	MAP3K6	1.59029044
20	STK38L	1.53657238
21	TAOK2	1.48766097
22	PHKG1	1.47187075
23	PHKG2	1.47187075
24	NUAK1	1.45989903
25	ITK	1.40914630
26	DAPK1	1.35140732
27	TBK1	1.30532436
28	ERN1	1.28244583
29	MAPKAPK3	1.24247586
30	NME2	1.20390724
31	SRPK1	1.19405083
32	TYRO3	1.16882038
33	IKBKE	1.15602758
34	MAP3K5	1.12523574
35	PRKCQ	1.12027970
36	CDK12	1.09120936
37	MAP2K4	1.08584169
38	PIK3CA	1.05658721
39	EIF2AK3	1.01639422
40	ATR	0.98968059
41	EIF2AK1	0.98909865
42	FLT3	0.96957936
43	EIF2AK2	0.93923026
44	LCK	0.92044512
45	IKBKB	0.91186436
46	SYK	0.89327562
47	CDK7	0.87288344
48	NEK1	0.86177826
49	STK38	0.80951307
50	MAP3K13	0.80897975
51	FGFR3	0.80135138
52	TAF1	0.79874793
53	FGFR4	0.79817184
54	MAPK11	0.79710596
55	ADRBK2	0.78990631
56	LYN	0.77859514
57	ALK	0.77118961
58	MAP3K11	0.76495619
59	RPS6KB2	0.70635984
60	CDK4	0.69976711
61	CSK	0.66600412
62	PLK3	0.66335225
63	IRAK3	0.66289752
64	NLK	0.61815288
65	GRK1	0.58902442
66	RAF1	0.58479955
67	ABL2	0.57402899
68	BLK	0.56219116
69	ATM	0.55896864
70	GRK7	0.55608525
71	SMG1	0.55488730
72	BTK	0.55215647
73	RPS6KB1	0.54615293
74	JAK2	0.52583287
75	DAPK2	0.51376299
76	ERBB3	0.51058664
77	KDR	0.50655526
78	PDK1	0.49149704
79	CSNK2A1	0.47028138
80	ZAP70	0.46841425
81	NEK6	0.43602810
82	HIPK2	0.42579647
83	PRPF4B	0.39259309
84	FYN	0.38411921
85	CDC7	0.37726455
86	PIM2	0.37263419
87	ABL1	0.36311221
88	CSNK1D	0.35087363
89	TESK2	0.34749889
90	MAPK3	0.30592301
91	RPS6KA1	0.28344640
92	TLK1	0.28282125
93	AURKB	0.26611806
94	CSNK1A1	0.25951156
95	CHEK1	0.25919085
96	PLK1	0.24341390
97	CSNK2A2	0.23072588
98	MAP3K3	0.22010578
99	HCK	0.21837670
100	BUB1	0.21184228

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Mismatch repair_Homo sapiens_hsa03430	3.77202420
2	Homologous recombination_Homo sapiens_hsa03440	3.49662413
3	DNA replication_Homo sapiens_hsa03030	3.33013241
4	Primary immunodeficiency_Homo sapiens_hsa05340	3.30257433
5	Allograft rejection_Homo sapiens_hsa05330	2.94324410
6	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.56576044
7	One carbon pool by folate_Homo sapiens_hsa00670	2.55241126
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.54870994
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.52382056
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.38859489
11	Antigen processing and presentation_Homo sapiens_hsa04612	2.04115567
12	Fanconi anemia pathway_Homo sapiens_hsa03460	1.90298427
13	Caffeine metabolism_Homo sapiens_hsa00232	1.83133658
14	Base excision repair_Homo sapiens_hsa03410	1.80697161
15	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.77667813
16	RNA transport_Homo sapiens_hsa03013	1.71426921
17	Proteasome_Homo sapiens_hsa03050	1.70271891
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.68469908
19	RNA polymerase_Homo sapiens_hsa03020	1.67813388
20	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.67520527
21	African trypanosomiasis_Homo sapiens_hsa05143	1.64865964
22	Asthma_Homo sapiens_hsa05310	1.53016725
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.51235256
24	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.47937355
25	Leishmaniasis_Homo sapiens_hsa05140	1.46305531
26	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.38977770
27	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.38123091
28	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.35123122
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.34066124
30	Ribosome_Homo sapiens_hsa03010	1.33836471
31	Measles_Homo sapiens_hsa05162	1.29404195
32	Spliceosome_Homo sapiens_hsa03040	1.28821813
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.24543040
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.23555212
35	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.22965096
36	Herpes simplex infection_Homo sapiens_hsa05168	1.20841449
37	Purine metabolism_Homo sapiens_hsa00230	1.19694920
38	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.19230176
39	Non-homologous end-joining_Homo sapiens_hsa03450	1.14964517
40	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.07711560
41	RNA degradation_Homo sapiens_hsa03018	1.07323962
42	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.05467533
43	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.05351527
44	Influenza A_Homo sapiens_hsa05164	1.05216457
45	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.02842057
46	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.95725225
47	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.95290734
48	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.88452055
49	Ether lipid metabolism_Homo sapiens_hsa00565	0.88281701
50	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.87779047
51	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.87426947
52	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.85208063
53	Pyrimidine metabolism_Homo sapiens_hsa00240	0.85116868
54	Cell cycle_Homo sapiens_hsa04110	0.81189716
55	Toxoplasmosis_Homo sapiens_hsa05145	0.80831531
56	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.80288028
57	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.79831510
58	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.78394962
59	Carbon metabolism_Homo sapiens_hsa01200	0.73331543
60	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.69566407
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67795479
62	Steroid biosynthesis_Homo sapiens_hsa00100	0.66037598
63	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.65633654
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.64170121
65	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.62008740
66	mRNA surveillance pathway_Homo sapiens_hsa03015	0.57903185
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57758070
68	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.53076719
69	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.51758753
70	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.51436243
71	Tuberculosis_Homo sapiens_hsa05152	0.49205926
72	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.48952009
73	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.48546966
74	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.47886506
75	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.46144762
76	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.45627752
77	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.43645929
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43150810
79	Olfactory transduction_Homo sapiens_hsa04740	0.42016617
80	Apoptosis_Homo sapiens_hsa04210	0.41174211
81	Fatty acid elongation_Homo sapiens_hsa00062	0.40837452
82	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.40736333
83	Acute myeloid leukemia_Homo sapiens_hsa05221	0.40299292
84	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.39174850
85	Viral myocarditis_Homo sapiens_hsa05416	0.38265421
86	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.38031991
87	Butanoate metabolism_Homo sapiens_hsa00650	0.37762549
88	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.37707353
89	Malaria_Homo sapiens_hsa05144	0.36135793
90	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.35201664
91	Peroxisome_Homo sapiens_hsa04146	0.35017982
92	HTLV-I infection_Homo sapiens_hsa05166	0.30495385
93	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.28908286
94	TNF signaling pathway_Homo sapiens_hsa04668	0.28242000
95	Complement and coagulation cascades_Homo sapiens_hsa04610	0.27931772
96	Circadian rhythm_Homo sapiens_hsa04710	0.27872322
97	Fatty acid degradation_Homo sapiens_hsa00071	0.24548360
98	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.23193594
99	Rheumatoid arthritis_Homo sapiens_hsa05323	0.22759785
100	Fatty acid metabolism_Homo sapiens_hsa01212	0.22709493

FAM96AP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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