FAM98C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.16184042
2L-fucose catabolic process (GO:0042355)5.66918680
3fucose catabolic process (GO:0019317)5.66918680
4L-fucose metabolic process (GO:0042354)5.66918680
5behavioral response to nicotine (GO:0035095)5.62775942
6vitamin transmembrane transport (GO:0035461)4.69819887
7ribosomal small subunit assembly (GO:0000028)4.58895544
8regulation of histone phosphorylation (GO:0033127)4.57383963
9determination of adult lifespan (GO:0008340)4.53387730
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.31903317
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.31903317
12response to pheromone (GO:0019236)4.30941279
13antigen processing and presentation via MHC class Ib (GO:0002475)4.24762717
14indole-containing compound catabolic process (GO:0042436)4.16983620
15indolalkylamine catabolic process (GO:0046218)4.16983620
16tryptophan catabolic process (GO:0006569)4.16983620
17viral transcription (GO:0019083)4.08761005
18kynurenine metabolic process (GO:0070189)4.02507737
19translational termination (GO:0006415)3.85313832
20indolalkylamine metabolic process (GO:0006586)3.83768878
21ubiquinone biosynthetic process (GO:0006744)3.83529664
22quinone biosynthetic process (GO:1901663)3.83529664
23antigen processing and presentation of endogenous antigen (GO:0019883)3.78132995
24fusion of sperm to egg plasma membrane (GO:0007342)3.76077723
25protein import into peroxisome matrix (GO:0016558)3.71166032
26translational elongation (GO:0006414)3.70956162
27negative regulation of telomere maintenance (GO:0032205)3.65748288
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.65018812
29cellular ketone body metabolic process (GO:0046950)3.60947081
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.58231076
31DNA damage induced protein phosphorylation (GO:0006975)3.57237408
32acrosome assembly (GO:0001675)3.47730201
33tryptophan metabolic process (GO:0006568)3.47667983
34negative regulation of erythrocyte differentiation (GO:0045647)3.44041824
35detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.40474957
36ribosomal small subunit biogenesis (GO:0042274)3.39429155
37galactose catabolic process (GO:0019388)3.38377220
38bile acid and bile salt transport (GO:0015721)3.34734992
39sperm motility (GO:0030317)3.34501983
40ubiquinone metabolic process (GO:0006743)3.32670930
41negative regulation of telomerase activity (GO:0051974)3.32363599
42positive regulation of gamma-delta T cell activation (GO:0046645)3.31319656
43fucosylation (GO:0036065)3.30921545
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.30143017
45detection of light stimulus involved in visual perception (GO:0050908)3.28906262
46detection of light stimulus involved in sensory perception (GO:0050962)3.28906262
47sulfation (GO:0051923)3.28366914
48regulation of early endosome to late endosome transport (GO:2000641)3.28337192
49regulation of gamma-delta T cell differentiation (GO:0045586)3.27726508
50indole-containing compound metabolic process (GO:0042430)3.23698082
51sperm-egg recognition (GO:0035036)3.21383958
52ketone body metabolic process (GO:1902224)3.19995628
53viral life cycle (GO:0019058)3.19809399
54protein targeting to ER (GO:0045047)3.16757124
55binding of sperm to zona pellucida (GO:0007339)3.16354866
56cell-cell recognition (GO:0009988)3.15523076
57cotranslational protein targeting to membrane (GO:0006613)3.15489843
58primary amino compound metabolic process (GO:1901160)3.14755452
59pentose-phosphate shunt (GO:0006098)3.13745663
60protein localization to endoplasmic reticulum (GO:0070972)3.12355288
61negative regulation of mast cell activation (GO:0033004)3.11153868
62positive regulation of B cell differentiation (GO:0045579)3.10497211
63pyrimidine-containing compound transmembrane transport (GO:0072531)3.10284638
64neuronal action potential (GO:0019228)3.10061926
65axonemal dynein complex assembly (GO:0070286)3.09838667
66platelet dense granule organization (GO:0060155)3.09752081
67morphogenesis of an epithelial fold (GO:0060571)3.08652848
68cellular protein complex disassembly (GO:0043624)3.07278618
69positive regulation of tolerance induction (GO:0002645)3.04253963
70serotonin metabolic process (GO:0042428)3.03063194
71water-soluble vitamin biosynthetic process (GO:0042364)3.02020078
72plasma membrane fusion (GO:0045026)3.00918788
73establishment of protein localization to endoplasmic reticulum (GO:0072599)2.99453082
74negative regulation of synaptic transmission, GABAergic (GO:0032229)2.99284956
75rRNA catabolic process (GO:0016075)2.98215225
76axoneme assembly (GO:0035082)2.98190518
77translational initiation (GO:0006413)2.97492594
78epithelial cilium movement (GO:0003351)2.95609260
79cilium or flagellum-dependent cell motility (GO:0001539)2.94819498
80maturation of SSU-rRNA (GO:0030490)2.92882894
81gamma-aminobutyric acid transport (GO:0015812)2.92641234
82NAD biosynthetic process (GO:0009435)2.92316842
83nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.91423421
84cellular biogenic amine catabolic process (GO:0042402)2.91192523
85amine catabolic process (GO:0009310)2.91192523
86regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.89928231
87behavioral response to ethanol (GO:0048149)2.89397925
88regulation of nuclear cell cycle DNA replication (GO:0033262)2.88287927
89translesion synthesis (GO:0019985)2.87931807
90protein complex biogenesis (GO:0070271)2.87159647
91sperm capacitation (GO:0048240)2.86392593
92negative regulation of innate immune response (GO:0045824)2.86078340
93regulation of T cell tolerance induction (GO:0002664)2.84456244
94preassembly of GPI anchor in ER membrane (GO:0016254)2.84434695
95regulation of gamma-delta T cell activation (GO:0046643)2.84151876
96cAMP catabolic process (GO:0006198)2.83555816
97interleukin-1-mediated signaling pathway (GO:0070498)2.83078230
98protein-cofactor linkage (GO:0018065)2.82413905
99respiratory chain complex IV assembly (GO:0008535)2.82323867
100production of molecular mediator involved in inflammatory response (GO:0002532)2.81636397
101mitochondrial respiratory chain complex I assembly (GO:0032981)2.81135451
102NADH dehydrogenase complex assembly (GO:0010257)2.81135451
103mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.81135451
104artery development (GO:0060840)2.81081432
105peptidyl-tyrosine autophosphorylation (GO:0038083)2.79594368
106protein complex disassembly (GO:0043241)2.78442326
107regulation of action potential (GO:0098900)2.78441067
108cellular response to ATP (GO:0071318)2.78132600
109positive regulation of CREB transcription factor activity (GO:0032793)2.77884995
110macrophage chemotaxis (GO:0048246)2.76111116
111nonmotile primary cilium assembly (GO:0035058)2.75894770
112DNA methylation involved in gamete generation (GO:0043046)2.75518667
113protein polyglutamylation (GO:0018095)2.75495701
114defense response to protozoan (GO:0042832)2.74682075
115JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.73060533
116phosphatidylinositol acyl-chain remodeling (GO:0036149)2.72348899
117acrosome reaction (GO:0007340)2.72173553
118protein localization to cilium (GO:0061512)2.72145326
119positive regulation of defense response to virus by host (GO:0002230)2.71601163
120piRNA metabolic process (GO:0034587)2.70175921
121kidney morphogenesis (GO:0060993)2.69977859
122glucose 6-phosphate metabolic process (GO:0051156)2.69420099
123response to protozoan (GO:0001562)2.69247060
124adaptation of signaling pathway (GO:0023058)2.67962164
125mitotic G1 DNA damage checkpoint (GO:0031571)2.67151088
126seminiferous tubule development (GO:0072520)2.66634226
127mitochondrial respiratory chain complex assembly (GO:0033108)2.66153161
128cornea development in camera-type eye (GO:0061303)2.65008435
129positive regulation of glycoprotein biosynthetic process (GO:0010560)2.64976510
130macromolecular complex disassembly (GO:0032984)2.64945230
131mast cell activation involved in immune response (GO:0002279)2.64807275
132mast cell degranulation (GO:0043303)2.64807275
133membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.63487784
134Arp2/3 complex-mediated actin nucleation (GO:0034314)2.63076149
135startle response (GO:0001964)2.62743767
136protein K11-linked deubiquitination (GO:0035871)2.62740043
137GDP-mannose metabolic process (GO:0019673)2.61812150
138positive regulation of fatty acid transport (GO:2000193)2.60704964
139positive regulation of glycoprotein metabolic process (GO:1903020)2.60403987
140regulation of hippo signaling (GO:0035330)2.60343420
141purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.60101554
1423-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.60101554
143cytochrome complex assembly (GO:0017004)2.59860105
144mast cell activation (GO:0045576)2.59394899
145reflex (GO:0060004)2.58823906
146lymphocyte chemotaxis (GO:0048247)2.58361996
147negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.57712494
148negative regulation of translation, ncRNA-mediated (GO:0040033)2.57712494
149regulation of translation, ncRNA-mediated (GO:0045974)2.57712494
150negative regulation of reactive oxygen species metabolic process (GO:2000378)2.57006862
151B cell receptor signaling pathway (GO:0050853)2.56022643
152retinal cone cell development (GO:0046549)2.55745981
153cell wall macromolecule catabolic process (GO:0016998)2.53962126
154cell wall macromolecule metabolic process (GO:0044036)2.53962126
155spermatid development (GO:0007286)2.53868151
156glycerophospholipid catabolic process (GO:0046475)2.53324057
157reciprocal meiotic recombination (GO:0007131)2.52804895
158reciprocal DNA recombination (GO:0035825)2.52804895
159spinal cord motor neuron differentiation (GO:0021522)2.52246310
160actin nucleation (GO:0045010)2.51630108
161telomere maintenance via semi-conservative replication (GO:0032201)2.51566715
162nephron tubule morphogenesis (GO:0072078)2.51114981
163nephron epithelium morphogenesis (GO:0072088)2.51114981
164cilium movement (GO:0003341)2.50990625
165oxidative demethylation (GO:0070989)2.49834255
166antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.49523593
167erythrocyte maturation (GO:0043249)2.49300338
168cyclic nucleotide catabolic process (GO:0009214)2.48877798
169regulation of tolerance induction (GO:0002643)2.47881937
170NADPH regeneration (GO:0006740)2.46225414
171lymphocyte migration (GO:0072676)2.46152208
172mitochondrion morphogenesis (GO:0070584)2.45931866
173positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.45742977
174aromatic amino acid family catabolic process (GO:0009074)2.45709346
175multicellular organism reproduction (GO:0032504)2.43807975
176maturation of 5.8S rRNA (GO:0000460)2.43774424
177negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43146092
178pseudouridine synthesis (GO:0001522)2.43015493
179proline transport (GO:0015824)2.42317603
180regulation of rhodopsin mediated signaling pathway (GO:0022400)2.40639026
181membrane depolarization during action potential (GO:0086010)2.40618637
182replication fork processing (GO:0031297)2.40288235
183regulation of T cell receptor signaling pathway (GO:0050856)2.40059060
184cellular hyperosmotic response (GO:0071474)2.39757301
185cilium morphogenesis (GO:0060271)2.39523344
186neural tube formation (GO:0001841)2.39339054
187cilium organization (GO:0044782)2.39175009
188sulfur compound transport (GO:0072348)2.38527725
189motile cilium assembly (GO:0044458)2.38464010
190response to interleukin-15 (GO:0070672)2.38254918
191regulation of B cell differentiation (GO:0045577)2.37983368
192negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.34886508
193regulation of cilium movement (GO:0003352)2.33738111

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.38139800
2VDR_22108803_ChIP-Seq_LS180_Human3.35662097
3EZH2_22144423_ChIP-Seq_EOC_Human3.31494860
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.07750700
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.78653011
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.76662342
7GBX2_23144817_ChIP-Seq_PC3_Human2.70512052
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.60047970
9MYC_22102868_ChIP-Seq_BL_Human2.56225015
10VDR_21846776_ChIP-Seq_THP-1_Human2.54763508
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.40578696
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18010772
13SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.10753280
14TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.05568038
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03484913
16FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.01144166
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96598898
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.95366990
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94115882
20SRY_22984422_ChIP-ChIP_TESTIS_Rat1.85727914
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.85112922
22IRF1_19129219_ChIP-ChIP_H3396_Human1.84883041
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.81607576
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.80861817
25REST_21632747_ChIP-Seq_MESCs_Mouse1.80661073
26ER_23166858_ChIP-Seq_MCF-7_Human1.79033401
27MAF_26560356_Chip-Seq_TH1_Human1.78935341
28TCF7_22412390_ChIP-Seq_EML_Mouse1.77933919
29IGF1R_20145208_ChIP-Seq_DFB_Human1.76813070
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.76685935
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.76653731
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.75780706
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.74740620
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.74101251
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71851851
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.70187405
37GATA1_22025678_ChIP-Seq_K562_Human1.67649656
38SCL_19346495_ChIP-Seq_HPC-7_Human1.66549631
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.66396255
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65876539
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65391705
42EWS_26573619_Chip-Seq_HEK293_Human1.64629260
43GATA1_22383799_ChIP-Seq_G1ME_Mouse1.61865381
44P300_19829295_ChIP-Seq_ESCs_Human1.61823213
45VDR_24763502_ChIP-Seq_THP-1_Human1.61545313
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60722794
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60263733
48MAF_26560356_Chip-Seq_TH2_Human1.59071942
49LXR_22292898_ChIP-Seq_THP-1_Human1.58200624
50TP53_22573176_ChIP-Seq_HFKS_Human1.57504574
51GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.57140615
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56560118
53BCOR_27268052_Chip-Seq_Bcells_Human1.56217619
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55622151
55CIITA_25753668_ChIP-Seq_RAJI_Human1.55222885
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55168524
57E2F7_22180533_ChIP-Seq_HELA_Human1.55152561
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54852707
59UTX_26944678_Chip-Seq_JUKART_Human1.54481134
60SPI1_23547873_ChIP-Seq_NB4_Human1.52975621
61DROSHA_22980978_ChIP-Seq_HELA_Human1.52209186
62BCL6_27268052_Chip-Seq_Bcells_Human1.51503702
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51434249
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51275696
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.51244657
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51045932
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.50868918
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.50824462
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50475158
70P68_20966046_ChIP-Seq_HELA_Human1.50252976
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.49407320
72TAF15_26573619_Chip-Seq_HEK293_Human1.49025702
73BCAT_22108803_ChIP-Seq_LS180_Human1.48959392
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48944228
75CTCF_26484167_Chip-Seq_Bcells_Mouse1.48703344
76MYB_26560356_Chip-Seq_TH2_Human1.46700570
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46095925
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.45741976
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.45741976
80PHF8_20622854_ChIP-Seq_HELA_Human1.44383775
81CTCF_18555785_ChIP-Seq_MESCs_Mouse1.43657654
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.42649079
83GATA2_22383799_ChIP-Seq_G1ME_Mouse1.40886702
84MYB_26560356_Chip-Seq_TH1_Human1.40852783
85FUS_26573619_Chip-Seq_HEK293_Human1.40793446
86STAT3_23295773_ChIP-Seq_U87_Human1.40613602
87* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39844253
88NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39744015
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38971380
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38771614
91ERA_21632823_ChIP-Seq_H3396_Human1.38662277
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38116915
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.37590800
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36367434
95ETS1_20019798_ChIP-Seq_JURKAT_Human1.35780530
96PU.1_20513432_ChIP-Seq_Bcells_Mouse1.35679336
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35662426
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34224679
99AR_25329375_ChIP-Seq_VCAP_Human1.32880272
100XRN2_22483619_ChIP-Seq_HELA_Human1.32781141
101EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32318145
102TCF4_23295773_ChIP-Seq_U87_Human1.32201368
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30814802
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30125411
105ELK3_25401928_ChIP-Seq_HUVEC_Human1.29368356
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29036848
107NCOR_22424771_ChIP-Seq_293T_Human1.28821963
108BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28728437
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28382643
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28382643
111MYC_18940864_ChIP-ChIP_HL60_Human1.27797328
112SPI1_23127762_ChIP-Seq_K562_Human1.27272950
113HOXB7_26014856_ChIP-Seq_BT474_Human1.26233653
114KDM2B_26808549_Chip-Seq_DND41_Human1.26077665
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25977573
116IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25957277
117TAF2_19829295_ChIP-Seq_ESCs_Human1.24863376
118YY1_21170310_ChIP-Seq_MESCs_Mouse1.23448088
119E2F1_20622854_ChIP-Seq_HELA_Human1.23321737
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22797562
121CBP_20019798_ChIP-Seq_JUKART_Human1.22797562
122CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21775705
123CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21167318
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20698603
125YY1_22570637_ChIP-Seq_MALME-3M_Human1.20265046
126EZH2_27294783_Chip-Seq_ESCs_Mouse1.20047159
127SA1_27219007_Chip-Seq_ERYTHROID_Human1.19718200
128NOTCH1_21737748_ChIP-Seq_TLL_Human1.19296271
129NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18689396
130TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18044296
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17950685
132NANOG_19829295_ChIP-Seq_ESCs_Human1.17947674
133SOX2_19829295_ChIP-Seq_ESCs_Human1.17947674
134SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17831232
135EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17788606
136MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17262780
137GATA1_19941827_ChIP-Seq_MEL_Mouse1.17057625
138AR_20517297_ChIP-Seq_VCAP_Human1.17034037
139SALL1_21062744_ChIP-ChIP_HESCs_Human1.17029461
140SA1_27219007_Chip-Seq_Bcells_Human1.15243672
141GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14749330
142PIAS1_25552417_ChIP-Seq_VCAP_Human1.14514885
143STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14240805
144REST_18959480_ChIP-ChIP_MESCs_Mouse1.13736744
145RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13683222
146PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12776973
147FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12295448
148STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12247600
149SMAD4_21799915_ChIP-Seq_A2780_Human1.11593251
150* MYC_19829295_ChIP-Seq_ESCs_Human1.11501038
151OCT4_20526341_ChIP-Seq_ESCs_Human1.11282957
152NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11023140
153NANOG_20526341_ChIP-Seq_ESCs_Human1.10753622
154PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10077507
155SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09772928
156TCF4_22108803_ChIP-Seq_LS180_Human1.09544921
157P300_27268052_Chip-Seq_Bcells_Human1.09271388
158AR_21572438_ChIP-Seq_LNCaP_Human1.09196298
159CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08798841
160EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08606010
161KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08374119
162SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07877406
163IRF8_21731497_ChIP-ChIP_J774_Mouse1.07570546
164PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07538746
165JARID2_20064375_ChIP-Seq_MESCs_Mouse1.07466364
166SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07360716
167FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07161615
168CTCF_21964334_ChIP-Seq_BJAB-B_Human1.07081780
169PRDM14_20953172_ChIP-Seq_ESCs_Human1.07055176
170MYC_19030024_ChIP-ChIP_MESCs_Mouse1.07018693
171RUNX2_22187159_ChIP-Seq_PCA_Human1.06845565
172SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05564065
173ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05545406
174PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05523911
175EZH2_27304074_Chip-Seq_ESCs_Mouse1.05491858
176RNF2_27304074_Chip-Seq_NSC_Mouse1.04640196
177P53_21459846_ChIP-Seq_SAOS-2_Human1.04606069
178ETS1_21867929_ChIP-Seq_TH2_Mouse1.04598588
179CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04500996
180RACK7_27058665_Chip-Seq_MCF-7_Human1.04359341
181ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03695781
182* GATA3_21867929_ChIP-Seq_CD8_Mouse1.03524340
183FLI1_21867929_ChIP-Seq_TH2_Mouse1.02775149
184CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02383376
185PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02200335
186GABP_19822575_ChIP-Seq_HepG2_Human1.01663457
187EED_16625203_ChIP-ChIP_MESCs_Mouse1.01088952
188SMC4_20622854_ChIP-Seq_HELA_Human1.01051853
189JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99966762
190BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99670805
191SMAD4_21741376_ChIP-Seq_EPCs_Human0.98850810
192MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98085152
193TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97876127
194TDRD3_21172665_ChIP-Seq_MCF-7_Human0.94404648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy4.06625243
2MP0001873_stomach_inflammation3.54056564
3MP0010234_abnormal_vibrissa_follicle3.18257945
4MP0005410_abnormal_fertilization3.05261632
5MP0005377_hearing/vestibular/ear_phenot3.02165712
6MP0003878_abnormal_ear_physiology3.02165712
7MP0005058_abnormal_lysosome_morphology2.97512897
8MP0001968_abnormal_touch/_nociception2.83125368
9MP0003195_calcinosis2.79949657
10MP0005257_abnormal_intraocular_pressure2.77569292
11MP0003866_abnormal_defecation2.77243049
12MP0005671_abnormal_response_to2.43853279
13MP0008877_abnormal_DNA_methylation2.40217348
14MP0001986_abnormal_taste_sensitivity2.36581844
15MP0005551_abnormal_eye_electrophysiolog2.33512811
16MP0002876_abnormal_thyroid_physiology2.28448585
17MP0000569_abnormal_digit_pigmentation2.26843391
18MP0002396_abnormal_hematopoietic_system2.26312702
19MP0009745_abnormal_behavioral_response2.22989479
20MP0000490_abnormal_crypts_of2.19750445
21MP0003646_muscle_fatigue2.19475098
22MP0004043_abnormal_pH_regulation2.18549746
23MP0009785_altered_susceptibility_to2.18300484
24MP0009046_muscle_twitch2.17872487
25MP0002736_abnormal_nociception_after2.13184215
26MP0002837_dystrophic_cardiac_calcinosis2.12506286
27MP0002653_abnormal_ependyma_morphology2.09966501
28MP0001835_abnormal_antigen_presentation2.09630238
29MP0000685_abnormal_immune_system2.09161698
30MP0003191_abnormal_cellular_cholesterol2.04231265
31MP0003693_abnormal_embryo_hatching2.03157304
32MP0001501_abnormal_sleep_pattern2.00341847
33MP0002102_abnormal_ear_morphology1.99082423
34MP0003763_abnormal_thymus_physiology1.97272698
35MP0004142_abnormal_muscle_tone1.93556073
36MP0010155_abnormal_intestine_physiology1.93553585
37MP0005670_abnormal_white_adipose1.93504747
38MP0009840_abnormal_foam_cell1.90515667
39MP0000427_abnormal_hair_cycle1.86128166
40MP0006292_abnormal_olfactory_placode1.84738105
41MP0003136_yellow_coat_color1.84579886
42MP0004885_abnormal_endolymph1.83141129
43MP0002272_abnormal_nervous_system1.79268843
44MP0005645_abnormal_hypothalamus_physiol1.75962531
45MP0005167_abnormal_blood-brain_barrier1.74869137
46MP0001545_abnormal_hematopoietic_system1.73857132
47MP0005397_hematopoietic_system_phenotyp1.73857132
48MP0003787_abnormal_imprinting1.73594196
49MP0002398_abnormal_bone_marrow1.73533352
50MP0005025_abnormal_response_to1.73184148
51MP0001800_abnormal_humoral_immune1.69120440
52MP0001819_abnormal_immune_cell1.67658913
53MP0001663_abnormal_digestive_system1.67051590
54MP0003880_abnormal_central_pattern1.66923295
55MP0002420_abnormal_adaptive_immunity1.66192600
56MP0005464_abnormal_platelet_physiology1.64689954
57MP0002064_seizures1.64318317
58MP0004742_abnormal_vestibular_system1.63760152
59MP0002723_abnormal_immune_serum1.62691996
60MP0009333_abnormal_splenocyte_physiolog1.60966165
61MP0001485_abnormal_pinna_reflex1.58934858
62MP0002735_abnormal_chemical_nociception1.58537881
63MP0006035_abnormal_mitochondrial_morpho1.58330918
64MP0005000_abnormal_immune_tolerance1.57477884
65MP0003300_gastrointestinal_ulcer1.54511620
66MP0004133_heterotaxia1.53812844
67MP0001666_abnormal_nutrient_absorption1.52216213
68MP0006036_abnormal_mitochondrial_physio1.49236581
69MP0005646_abnormal_pituitary_gland1.49072719
70MP0000716_abnormal_immune_system1.48829678
71MP0002572_abnormal_emotion/affect_behav1.47163323
72MP0002722_abnormal_immune_system1.47036439
73MP0002452_abnormal_antigen_presenting1.46877510
74MP0003724_increased_susceptibility_to1.46062296
75MP0008872_abnormal_physiological_respon1.44229751
76MP0006072_abnormal_retinal_apoptosis1.43182728
77MP0002733_abnormal_thermal_nociception1.42311183
78MP0001970_abnormal_pain_threshold1.40817810
79MP0001486_abnormal_startle_reflex1.40282242
80MP0008875_abnormal_xenobiotic_pharmacok1.40276895
81MP0005360_urolithiasis1.37461288
82MP0002429_abnormal_blood_cell1.37265179
83MP0000689_abnormal_spleen_morphology1.36876432
84MP0005075_abnormal_melanosome_morpholog1.36580298
85MP0006276_abnormal_autonomic_nervous1.36076235
86MP0003879_abnormal_hair_cell1.34656289
87MP0000631_abnormal_neuroendocrine_gland1.34561384
88MP0000465_gastrointestinal_hemorrhage1.32931578
89MP0004947_skin_inflammation1.32697912
90MP0005085_abnormal_gallbladder_physiolo1.32392129
91MP0002557_abnormal_social/conspecific_i1.29342190
92MP0003635_abnormal_synaptic_transmissio1.29090055
93MP0005253_abnormal_eye_physiology1.28110665
94MP0005174_abnormal_tail_pigmentation1.27174853
95MP0002063_abnormal_learning/memory/cond1.26973854
96MP0002638_abnormal_pupillary_reflex1.26430203
97MP0002067_abnormal_sensory_capabilities1.24787431
98MP0002163_abnormal_gland_morphology1.23489295
99MP0002148_abnormal_hypersensitivity_rea1.22713748
100MP0001845_abnormal_inflammatory_respons1.22646529
101MP0001790_abnormal_immune_system1.21260424
102MP0005387_immune_system_phenotype1.21260424
103MP0003011_delayed_dark_adaptation1.21091356
104MP0002928_abnormal_bile_duct1.20566058
105MP0001919_abnormal_reproductive_system1.19639901
106MP0000477_abnormal_intestine_morphology1.19534081
107MP0005389_reproductive_system_phenotype1.18606287
108MP0002938_white_spotting1.17472000
109MP0002419_abnormal_innate_immunity1.17278972
110MP0003698_abnormal_male_reproductive1.16093821
111MP0004019_abnormal_vitamin_homeostasis1.16008538
112MP0002277_abnormal_respiratory_mucosa1.14309504
113MP0000013_abnormal_adipose_tissue1.13922437
114MP0008873_increased_physiological_sensi1.13438474
115MP0004130_abnormal_muscle_cell1.12502026
116MP0005381_digestive/alimentary_phenotyp1.12153555
117MP0010352_gastrointestinal_tract_polyps1.11816894
118MP0001929_abnormal_gametogenesis1.11307430
119MP0002166_altered_tumor_susceptibility1.10672020
120MP0005386_behavior/neurological_phenoty1.10584226
121MP0004924_abnormal_behavior1.10584226
122MP0000358_abnormal_cell_content/1.09321551
123MP0000703_abnormal_thymus_morphology1.09314332
124MP0004264_abnormal_extraembryonic_tissu1.09023757
125MP0000383_abnormal_hair_follicle1.07668558
126MP0005310_abnormal_salivary_gland1.07322435
127MP0002160_abnormal_reproductive_system1.05338917
128MP0003111_abnormal_nucleus_morphology1.05232395
129MP0005084_abnormal_gallbladder_morpholo1.05218224
130MP0005423_abnormal_somatic_nervous1.05000498
131MP0002254_reproductive_system_inflammat1.04824077
132MP0008469_abnormal_protein_level1.04383333
133MP0004957_abnormal_blastocyst_morpholog1.03255205
134MP0003806_abnormal_nucleotide_metabolis1.02991163
135MP0000372_irregular_coat_pigmentation1.02373602
136MP0001765_abnormal_ion_homeostasis1.02253979
137MP0009643_abnormal_urine_homeostasis1.01423770
138MP0001905_abnormal_dopamine_level1.00940283
139MP0002405_respiratory_system_inflammati1.00223234
140MP0000230_abnormal_systemic_arterial0.99793794
141MP0003303_peritoneal_inflammation0.99704713
142MP0003436_decreased_susceptibility_to0.97786519
143MP0002234_abnormal_pharynx_morphology0.96557887
144MP0004145_abnormal_muscle_electrophysio0.95556633
145MP0002095_abnormal_skin_pigmentation0.95099241
146MP0002693_abnormal_pancreas_physiology0.94861607
147MP0005448_abnormal_energy_balance0.94686150
148MP0005195_abnormal_posterior_eye0.93942837
149MP0005379_endocrine/exocrine_gland_phen0.93639040
150MP0002019_abnormal_tumor_incidence0.93438939
151MP0001502_abnormal_circadian_rhythm0.92985727
152MP0002132_abnormal_respiratory_system0.92469190
153MP0005636_abnormal_mineral_homeostasis0.91328569
154MP0002734_abnormal_mechanical_nocicepti0.91236472
155MP0002229_neurodegeneration0.88759037
156MP0004808_abnormal_hematopoietic_stem0.87879477
157MP0001984_abnormal_olfaction0.87700288
158MP0000026_abnormal_inner_ear0.87680152
159MP0002138_abnormal_hepatobiliary_system0.87669015
160MP0003172_abnormal_lysosome_physiology0.86780779
161MP0000015_abnormal_ear_pigmentation0.86153043
162MP0003137_abnormal_impulse_conducting0.85855793
163MP0003283_abnormal_digestive_organ0.85849993
164MP0010386_abnormal_urinary_bladder0.85698926
165MP0005584_abnormal_enzyme/coenzyme_acti0.84059889
166MP0008961_abnormal_basal_metabolism0.82225801
167MP0005365_abnormal_bile_salt0.82033800
168MP0002752_abnormal_somatic_nervous0.80504254
169MP0004147_increased_porphyrin_level0.80087376
170MP0009764_decreased_sensitivity_to0.79894293
171MP0001963_abnormal_hearing_physiology0.78655555
172MP0010094_abnormal_chromosome_stability0.78358162
173MP0010329_abnormal_lipoprotein_level0.78340898
174MP0008775_abnormal_heart_ventricle0.77267621
175MP0001664_abnormal_digestion0.76835763
176MP0008995_early_reproductive_senescence0.75103955
177MP0005319_abnormal_enzyme/_coenzyme0.74895768
178MP0000313_abnormal_cell_death0.74128700
179MP0002909_abnormal_adrenal_gland0.71870569
180MP0001853_heart_inflammation0.71673662
181MP0000609_abnormal_liver_physiology0.71321318
182MP0008007_abnormal_cellular_replicative0.70271239
183MP0009278_abnormal_bone_marrow0.68066039
184MP0005083_abnormal_biliary_tract0.65837968

Predicted human phenotypes

RankGene SetZ-score
1Malnutrition (HP:0004395)4.69804332
2Nasal polyposis (HP:0100582)4.69799830
3Pancreatic cysts (HP:0001737)4.68985549
4Abnormality of small intestinal villus morphology (HP:0011472)4.60848306
5Villous atrophy (HP:0011473)4.60848306
6Abnormality of midbrain morphology (HP:0002418)4.32099141
7Molar tooth sign on MRI (HP:0002419)4.32099141
8Abnormality of the nasal mucosa (HP:0000433)4.29227357
9Pustule (HP:0200039)4.20863649
10Congenital stationary night blindness (HP:0007642)4.07425541
11Pancreatic fibrosis (HP:0100732)4.06914556
12Prostate neoplasm (HP:0100787)4.03013134
13True hermaphroditism (HP:0010459)3.84242901
14Chronic otitis media (HP:0000389)3.81865368
15Nephronophthisis (HP:0000090)3.63059054
16Petechiae (HP:0000967)3.61826465
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.59607691
18Absent/shortened dynein arms (HP:0200106)3.53914413
19Dynein arm defect of respiratory motile cilia (HP:0012255)3.53914413
20Hyperventilation (HP:0002883)3.44747912
21Abnormal number of erythroid precursors (HP:0012131)3.43854387
22Abnormality of cells of the erythroid lineage (HP:0012130)3.35441336
23Abnormality of the renal cortex (HP:0011035)3.33484964
24Recurrent bronchitis (HP:0002837)3.32448167
25IgM deficiency (HP:0002850)3.28199232
26Abnormality of the prostate (HP:0008775)3.27744644
27Abnormality of alanine metabolism (HP:0010916)3.25903546
28Hyperalaninemia (HP:0003348)3.25903546
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.25903546
30Type II lissencephaly (HP:0007260)3.24978797
31Panhypogammaglobulinemia (HP:0003139)3.17694082
32Abnormality of the renal medulla (HP:0100957)3.15765072
33Thrombocytosis (HP:0001894)3.12035913
34Gastrointestinal inflammation (HP:0004386)3.10694857
35Inflammation of the large intestine (HP:0002037)3.07375659
36Attenuation of retinal blood vessels (HP:0007843)3.06130845
37Vacuolated lymphocytes (HP:0001922)3.02960713
38Cystic liver disease (HP:0006706)3.01867021
39Abnormality of T cell physiology (HP:0011840)3.00708997
40Bronchitis (HP:0012387)3.00641374
41Recurrent sinusitis (HP:0011108)2.97365002
42Tubular atrophy (HP:0000092)2.91479211
43Inability to walk (HP:0002540)2.89272455
44Colitis (HP:0002583)2.87966229
45Abnormal drinking behavior (HP:0030082)2.85758811
46Polydipsia (HP:0001959)2.85758811
47Large for gestational age (HP:0001520)2.85735753
48Oligomenorrhea (HP:0000876)2.83012865
49Prolonged bleeding time (HP:0003010)2.81943243
50Abnormal respiratory epithelium morphology (HP:0012253)2.79841719
51Abnormal respiratory motile cilium morphology (HP:0005938)2.79841719
52Elevated erythrocyte sedimentation rate (HP:0003565)2.75478487
53Progressive inability to walk (HP:0002505)2.73852269
54Abolished electroretinogram (ERG) (HP:0000550)2.72680602
55Chronic hepatic failure (HP:0100626)2.69867916
56Progressive cerebellar ataxia (HP:0002073)2.68278432
57Polygenic inheritance (HP:0010982)2.65790751
58Reticulocytopenia (HP:0001896)2.65041160
59Furrowed tongue (HP:0000221)2.63377122
60Genetic anticipation (HP:0003743)2.56190131
61Medial flaring of the eyebrow (HP:0010747)2.55951256
62Decreased circulating renin level (HP:0003351)2.55558648
63Concave nail (HP:0001598)2.55481142
64Abnormal respiratory motile cilium physiology (HP:0012261)2.53303577
65Bronchiectasis (HP:0002110)2.53257077
66Chronic bronchitis (HP:0004469)2.52931183
67Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.50201554
68Progressive muscle weakness (HP:0003323)2.49528613
69Recurrent viral infections (HP:0004429)2.47187247
70Sclerocornea (HP:0000647)2.46837844
71Congenital, generalized hypertrichosis (HP:0004540)2.46437224
72Recurrent fungal infections (HP:0002841)2.46286663
73Abnormal delayed hypersensitivity skin test (HP:0002963)2.46216761
74Clumsiness (HP:0002312)2.46154298
75Abnormality of T cells (HP:0002843)2.44597887
76Protruding tongue (HP:0010808)2.44481638
77Pendular nystagmus (HP:0012043)2.43973202
78Gaze-evoked nystagmus (HP:0000640)2.39940973
79Recurrent abscess formation (HP:0002722)2.39697673
80Impaired platelet aggregation (HP:0003540)2.39165643
81Abnormal platelet function (HP:0011869)2.39165643
82Patellar aplasia (HP:0006443)2.38679575
83Abnormal rod and cone electroretinograms (HP:0008323)2.37837276
84Abnormal biliary tract physiology (HP:0012439)2.37352659
85Bile duct proliferation (HP:0001408)2.37352659
86Rhinitis (HP:0012384)2.37238715
87Microretrognathia (HP:0000308)2.32360999
88Severe muscular hypotonia (HP:0006829)2.31679765
89Cerebellar dysplasia (HP:0007033)2.30728094
90Lissencephaly (HP:0001339)2.30561135
91Aplasia/Hypoplasia of the patella (HP:0006498)2.29583711
92Increased IgE level (HP:0003212)2.28530529
93Aplasia/Hypoplasia of the tibia (HP:0005772)2.26695468
94Polyuria (HP:0000103)2.25452600
95Infertility (HP:0000789)2.25407095
96Reduced antithrombin III activity (HP:0001976)2.23331064
97Stomach cancer (HP:0012126)2.19865093
98Febrile seizures (HP:0002373)2.19449666
99Abnormality of macrophages (HP:0004311)2.17925066
100Increased neuronal autofluorescent lipopigment (HP:0002074)2.17797178
101Broad-based gait (HP:0002136)2.17510887
102Chronic mucocutaneous candidiasis (HP:0002728)2.16913724
103Recurrent cutaneous fungal infections (HP:0011370)2.16913724
104Renal cortical cysts (HP:0000803)2.16026326
105Aplastic anemia (HP:0001915)2.15043202
106Abnormality of the pons (HP:0007361)2.14609734
107Cholecystitis (HP:0001082)2.14207608
108Abnormal gallbladder physiology (HP:0012438)2.14207608
109Congenital hepatic fibrosis (HP:0002612)2.13829292
110Hypoplasia of the pons (HP:0012110)2.13377510
111Decreased electroretinogram (ERG) amplitude (HP:0000654)2.11894687
112Cheilitis (HP:0100825)2.11227910
113Increased corneal curvature (HP:0100692)2.09852599
114Keratoconus (HP:0000563)2.09852599
115Reduced subcutaneous adipose tissue (HP:0003758)2.09822937
116Myositis (HP:0100614)2.08463263
117Toxemia of pregnancy (HP:0100603)2.08413349
118Hyperlipoproteinemia (HP:0010980)2.08228699
119Chronic sinusitis (HP:0011109)2.07850121
120Anencephaly (HP:0002323)2.06815403
121Recurrent bacterial skin infections (HP:0005406)2.05939789
122B lymphocytopenia (HP:0010976)2.05872340
123Abnormality of B cell number (HP:0010975)2.05872340
124Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04639782
125Decreased central vision (HP:0007663)2.03602422
126Gait imbalance (HP:0002141)2.03313573
127Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00852722
128Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00852722
129Pallor (HP:0000980)1.99376665
130Hemiparesis (HP:0001269)1.98749115
131Hyperuricemia (HP:0002149)1.97729450
132Increased purine levels (HP:0004368)1.97729450
133Dysostosis multiplex (HP:0000943)1.97454572
134Palpitations (HP:0001962)1.97254912
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.96538332
136Recurrent otitis media (HP:0000403)1.96405210
137Abnormal ciliary motility (HP:0012262)1.96325558
138Aplasia/Hypoplasia of the spleen (HP:0010451)1.95362262
139Poikiloderma (HP:0001029)1.94957315
140Congenital sensorineural hearing impairment (HP:0008527)1.94872400
141Birth length less than 3rd percentile (HP:0003561)1.94468660
142Epistaxis (HP:0000421)1.93688318
143Absent speech (HP:0001344)1.93334884
144Severe visual impairment (HP:0001141)1.93175105
145Albinism (HP:0001022)1.92581218
146Agammaglobulinemia (HP:0004432)1.92166691
147Ketosis (HP:0001946)1.92083173
148Flat acetabular roof (HP:0003180)1.91502097
149Chronic diarrhea (HP:0002028)1.91320734
150Male pseudohermaphroditism (HP:0000037)1.90911272
151Congenital primary aphakia (HP:0007707)1.90667630
152Chorioretinal atrophy (HP:0000533)1.88083078
153Death in infancy (HP:0001522)1.85026146
154Brushfield spots (HP:0001088)1.84050190
155Tachypnea (HP:0002789)1.83600050
156Ketoacidosis (HP:0001993)1.83011139
157Bony spicule pigmentary retinopathy (HP:0007737)1.82928099
158Fatigue (HP:0012378)1.82581458
159Meningitis (HP:0001287)1.79804920
160Progressive microcephaly (HP:0000253)1.79419298
161Optic disc pallor (HP:0000543)1.79289133
162Abnormal protein glycosylation (HP:0012346)1.78928640
163Abnormal glycosylation (HP:0012345)1.78928640
164Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78928640
165Abnormal protein N-linked glycosylation (HP:0012347)1.78928640
166Nephrogenic diabetes insipidus (HP:0009806)1.78736206
167Stomatitis (HP:0010280)1.78718625
168Abnormal urine output (HP:0012590)1.78685372
169Generalized aminoaciduria (HP:0002909)1.76502434
170Pachygyria (HP:0001302)1.76045631
171Recurrent skin infections (HP:0001581)1.75917023
172Widely spaced teeth (HP:0000687)1.75131967
173Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.74510827
174Thoracic kyphosis (HP:0002942)1.74183735
175Abnormality of reticulocytes (HP:0004312)1.73721497
176Granulocytopenia (HP:0001913)1.71379044
177Macrocytic anemia (HP:0001972)1.71049831
178Microcytic anemia (HP:0001935)1.70984039
179Asplenia (HP:0001746)1.70959079
180Easy fatigability (HP:0003388)1.70876115
181Abnormality of fatty-acid metabolism (HP:0004359)1.69658144
182Mitochondrial inheritance (HP:0001427)1.69316319
183Increased CSF lactate (HP:0002490)1.68024935
184Abnormality of the renal collecting system (HP:0004742)1.67050122
185Right ventricular cardiomyopathy (HP:0011663)1.65795207
186Combined immunodeficiency (HP:0005387)1.65622503
187Focal seizures (HP:0007359)1.65484706
188Postaxial foot polydactyly (HP:0001830)1.64674594
189Focal motor seizures (HP:0011153)1.63206754
190Duplicated collecting system (HP:0000081)1.62705292
191Rib fusion (HP:0000902)1.62233714
192Retinal dysplasia (HP:0007973)1.61299992
193Polyphagia (HP:0002591)1.61200373
194Bulbous nose (HP:0000414)1.60282970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R7.68338621
2FRK6.48338496
3PIK3CA4.62941225
4KSR24.59316940
5ADRBK23.84168080
6MAP3K23.77918762
7BMPR1B2.98412842
8EEF2K2.95610904
9WNK42.85659182
10TLK12.84908159
11ZAK2.78712565
12MAP4K12.55037302
13MAP2K22.53706708
14GRK12.37176727
15INSRR2.35415731
16DAPK22.31387301
17MAP4K22.29858153
18WNK32.23158279
19NME12.11917857
20ACVR1B2.10346126
21PINK12.02649340
22MAPKAPK31.94813140
23MAPK131.94428538
24NUAK11.88966883
25MET1.86696304
26OXSR11.76309756
27TXK1.72095544
28MAP3K11.61767587
29ADRBK11.51231636
30PDK41.51202387
31PDK31.51202387
32CASK1.47404934
33TESK21.42256030
34FLT31.38837464
35TESK11.37074084
36KIT1.36528142
37STK391.34705606
38TAOK31.34151120
39KDR1.31467342
40BLK1.27121352
41MAP2K11.26522495
42BTK1.26457633
43BUB11.22255234
44ZAP701.21621582
45GRK61.21110367
46WEE11.20663602
47NME21.18382805
48MAP3K41.11143460
49MAP3K81.10645123
50TBK11.10187090
51PAK31.07731233
52STK161.06033244
53TYK21.04596352
54IKBKB1.03554313
55NEK21.02963244
56RPS6KB21.02355428
57PIM21.01089068
58SCYL20.97344115
59RIPK40.96817636
60TEC0.95985169
61MARK10.94023312
62ERN10.93662229
63NTRK30.92328150
64TAOK10.92058792
65TNK20.91236787
66DYRK20.88716961
67DYRK30.87818139
68LMTK20.86899178
69SYK0.86612502
70TGFBR10.85517334
71PRKG20.83758149
72CSF1R0.83749263
73PRKCG0.83563624
74RET0.81322624
75LRRK20.81194286
76RAF10.78373846
77PKN10.75594295
78IRAK40.75449688
79MAP2K70.75367815
80STK110.74642566
81PRKCE0.73891897
82PRKCQ0.73549399
83MAP3K130.70909146
84PKN20.69994386
85CHUK0.68209887
86MAP3K110.67610535
87PHKG10.66626140
88PHKG20.66626140
89ITK0.66550566
90TIE10.66318616
91RPS6KA50.66090661
92MAPK150.64372883
93MKNK20.64220312
94MAPKAPK50.62544804
95FES0.61804127
96MAP3K100.60889925
97JAK20.60178499
98BCKDK0.59417280
99CDK190.58400700
100JAK30.57940542
101MAPK110.56268296
102MAP2K60.55282739
103IKBKE0.55255044
104SIK20.55109449
105RPS6KA60.54642839
106LYN0.54214755
107EPHA40.53056859
108LCK0.52765202
109PRKCI0.52484713
110ARAF0.52011410
111EPHA30.51472907
112MAP3K90.51172571
113MUSK0.50183974
114MATK0.49896653
115BRSK20.49780726
116NTRK20.49744292
117TRIB30.49592812
118CAMKK10.48885640
119DAPK10.48510970
120CAMKK20.48193452
121PDK20.47639766
122VRK10.47583515
123CAMK2A0.47266403
124CDK90.46686597
125MAP2K40.45927875
126PRKAA20.44730779
127PRKACA0.44150865
128CDK40.43779867
129RPS6KA40.42510052
130PRKCZ0.42166532
131CSNK1G20.41655852
132FGFR20.41559091
133DYRK1B0.41171189
134IRAK10.41024796
135MAP3K70.40579229
136PIM10.39662159
137PASK0.39477127
138PAK40.39280668
139CAMK1D0.39019286
140PRKAA10.38838840
141ICK0.38790757
142PDK10.38650136
143STK100.38083879
144NEK10.37929089
145TNIK0.37529259
146PTK2B0.37315565
147CAMK10.37124739
148PRKCA0.36391998
149CAMK2D0.35603714
150CSNK1A10.34985961
151PRKCH0.33866009
152CSNK1G30.33832545
153MAP3K120.33237571
154PAK60.33023683
155CSNK1G10.32944668
156TRPM70.32296919
157PNCK0.31469745
158CAMK40.30950753
159STK38L0.30407580
160TSSK60.30405264
161MAP2K30.30154700
162GRK50.29781908
163PRKD30.27640287
164HCK0.27433115
165CDK70.27329583
166NLK0.25619553
167ATR0.25192301
168JAK10.24614889

Predicted pathways (KEGG)

RankGene SetZ-score
1Mineral absorption_Homo sapiens_hsa049783.31110609
2Ribosome_Homo sapiens_hsa030103.23013449
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.04608559
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.99085302
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.82604888
6Linoleic acid metabolism_Homo sapiens_hsa005912.82602323
7Nitrogen metabolism_Homo sapiens_hsa009102.82383682
8Pentose phosphate pathway_Homo sapiens_hsa000302.73657732
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.67074529
10Phototransduction_Homo sapiens_hsa047442.66462572
11DNA replication_Homo sapiens_hsa030302.62561097
12Thyroid cancer_Homo sapiens_hsa052162.51688118
13Primary immunodeficiency_Homo sapiens_hsa053402.50775078
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.42245710
15Folate biosynthesis_Homo sapiens_hsa007902.40987624
16Nicotine addiction_Homo sapiens_hsa050332.34897077
17Butanoate metabolism_Homo sapiens_hsa006502.20585033
18Sulfur relay system_Homo sapiens_hsa041222.20583183
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20101107
20Fructose and mannose metabolism_Homo sapiens_hsa000512.19187341
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.12277127
22Galactose metabolism_Homo sapiens_hsa000521.95572217
23Ether lipid metabolism_Homo sapiens_hsa005651.90659919
24B cell receptor signaling pathway_Homo sapiens_hsa046621.89497942
25Tryptophan metabolism_Homo sapiens_hsa003801.80165970
26Oxidative phosphorylation_Homo sapiens_hsa001901.79603329
27Antigen processing and presentation_Homo sapiens_hsa046121.79278599
28Other glycan degradation_Homo sapiens_hsa005111.77003951
29Bile secretion_Homo sapiens_hsa049761.71964733
30Morphine addiction_Homo sapiens_hsa050321.60228736
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.59259157
32Mismatch repair_Homo sapiens_hsa034301.58132733
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.56157294
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.49870457
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49499432
36Base excision repair_Homo sapiens_hsa034101.44921400
37Pyrimidine metabolism_Homo sapiens_hsa002401.44032382
38Taste transduction_Homo sapiens_hsa047421.42086956
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.40864792
40Acute myeloid leukemia_Homo sapiens_hsa052211.40294840
41Fanconi anemia pathway_Homo sapiens_hsa034601.39166445
42Glycerolipid metabolism_Homo sapiens_hsa005611.33550907
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28268028
44Spliceosome_Homo sapiens_hsa030401.26195309
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25163200
46Peroxisome_Homo sapiens_hsa041461.22057971
47Proteasome_Homo sapiens_hsa030501.20042616
48Arachidonic acid metabolism_Homo sapiens_hsa005901.19865740
49Insulin secretion_Homo sapiens_hsa049111.18476115
50Parkinsons disease_Homo sapiens_hsa050121.17641319
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15855908
52Circadian entrainment_Homo sapiens_hsa047131.11858472
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10580784
54RNA polymerase_Homo sapiens_hsa030201.09900809
55Biosynthesis of amino acids_Homo sapiens_hsa012301.08294138
56Chemical carcinogenesis_Homo sapiens_hsa052041.07568649
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.06728531
58Basal transcription factors_Homo sapiens_hsa030221.06626644
59ABC transporters_Homo sapiens_hsa020101.06424270
60T cell receptor signaling pathway_Homo sapiens_hsa046601.05869839
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03626566
62Carbon metabolism_Homo sapiens_hsa012001.03147252
63Central carbon metabolism in cancer_Homo sapiens_hsa052301.00823263
64GABAergic synapse_Homo sapiens_hsa047271.00164988
65Serotonergic synapse_Homo sapiens_hsa047260.99427860
66Leishmaniasis_Homo sapiens_hsa051400.99410442
67Glutamatergic synapse_Homo sapiens_hsa047240.98945381
68Ovarian steroidogenesis_Homo sapiens_hsa049130.98278567
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.97290560
70Fat digestion and absorption_Homo sapiens_hsa049750.96737839
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.96592757
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96201002
73Asthma_Homo sapiens_hsa053100.96059358
74Regulation of autophagy_Homo sapiens_hsa041400.95637790
75Shigellosis_Homo sapiens_hsa051310.95402701
76One carbon pool by folate_Homo sapiens_hsa006700.95045529
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94734237
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94491762
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93466668
80Hematopoietic cell lineage_Homo sapiens_hsa046400.93382128
81Collecting duct acid secretion_Homo sapiens_hsa049660.92928703
82Salivary secretion_Homo sapiens_hsa049700.92420079
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91896594
84Selenocompound metabolism_Homo sapiens_hsa004500.91492020
85Histidine metabolism_Homo sapiens_hsa003400.91303502
86Bladder cancer_Homo sapiens_hsa052190.91042696
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90627797
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90401264
89Cardiac muscle contraction_Homo sapiens_hsa042600.90237147
90Osteoclast differentiation_Homo sapiens_hsa043800.86424373
91Calcium signaling pathway_Homo sapiens_hsa040200.86368199
92Renin-angiotensin system_Homo sapiens_hsa046140.83924579
93Graft-versus-host disease_Homo sapiens_hsa053320.83824701
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.83747568
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83683289
96Purine metabolism_Homo sapiens_hsa002300.83291754
97RNA transport_Homo sapiens_hsa030130.81791488
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81685553
99Homologous recombination_Homo sapiens_hsa034400.81570711
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80725438
101Sulfur metabolism_Homo sapiens_hsa009200.80356469
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.78839827
103Alzheimers disease_Homo sapiens_hsa050100.76200844
104Retinol metabolism_Homo sapiens_hsa008300.75746070
105RNA degradation_Homo sapiens_hsa030180.75645070
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74822246
107Pyruvate metabolism_Homo sapiens_hsa006200.74573883
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74555602
109Type I diabetes mellitus_Homo sapiens_hsa049400.73630782
110VEGF signaling pathway_Homo sapiens_hsa043700.72661530
111Allograft rejection_Homo sapiens_hsa053300.70413876
112Salmonella infection_Homo sapiens_hsa051320.68108626
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67594937
114N-Glycan biosynthesis_Homo sapiens_hsa005100.66838840
115Autoimmune thyroid disease_Homo sapiens_hsa053200.66658378
116Type II diabetes mellitus_Homo sapiens_hsa049300.66546216
117Caffeine metabolism_Homo sapiens_hsa002320.66352038
118Herpes simplex infection_Homo sapiens_hsa051680.66017208
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65633323
120Platelet activation_Homo sapiens_hsa046110.64973669
121Influenza A_Homo sapiens_hsa051640.64021919
122Protein export_Homo sapiens_hsa030600.63946496
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62707851
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.61562553
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.60610898
126Legionellosis_Homo sapiens_hsa051340.60600391
127Dorso-ventral axis formation_Homo sapiens_hsa043200.60069321
128Vitamin digestion and absorption_Homo sapiens_hsa049770.59394543
129Olfactory transduction_Homo sapiens_hsa047400.58825700
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57440910
131Chronic myeloid leukemia_Homo sapiens_hsa052200.55863306
132beta-Alanine metabolism_Homo sapiens_hsa004100.55737126
133Non-small cell lung cancer_Homo sapiens_hsa052230.55721967
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55475708
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.55015255
136Dopaminergic synapse_Homo sapiens_hsa047280.53712117
137Cocaine addiction_Homo sapiens_hsa050300.51441453
138Cholinergic synapse_Homo sapiens_hsa047250.49896882
139HIF-1 signaling pathway_Homo sapiens_hsa040660.49883191
140Pertussis_Homo sapiens_hsa051330.49233287
141Metabolic pathways_Homo sapiens_hsa011000.48846395
142Hepatitis C_Homo sapiens_hsa051600.48349476
143Apoptosis_Homo sapiens_hsa042100.45139902
144cAMP signaling pathway_Homo sapiens_hsa040240.44832823
145Propanoate metabolism_Homo sapiens_hsa006400.44521703
146Gastric acid secretion_Homo sapiens_hsa049710.44124799
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43675348
148RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43139033
149Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41870933
150Long-term depression_Homo sapiens_hsa047300.40773356
151Oxytocin signaling pathway_Homo sapiens_hsa049210.40290947
152Long-term potentiation_Homo sapiens_hsa047200.38425989
153Maturity onset diabetes of the young_Homo sapiens_hsa049500.38243115
154Pancreatic secretion_Homo sapiens_hsa049720.37824388
155Huntingtons disease_Homo sapiens_hsa050160.37784011
156SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37463786
157Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37218853
158Prion diseases_Homo sapiens_hsa050200.37124408
159Amphetamine addiction_Homo sapiens_hsa050310.36428170
160Endocytosis_Homo sapiens_hsa041440.36228095
161Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35886231
162Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35556369
163Cyanoamino acid metabolism_Homo sapiens_hsa004600.35411432
164Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32622178
165Toxoplasmosis_Homo sapiens_hsa051450.32462717
166Rheumatoid arthritis_Homo sapiens_hsa053230.32253651
167Insulin signaling pathway_Homo sapiens_hsa049100.32081968
168Measles_Homo sapiens_hsa051620.30868987
169NF-kappa B signaling pathway_Homo sapiens_hsa040640.27304584
170Tuberculosis_Homo sapiens_hsa051520.27099010

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