FAM9A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a gene family which arose through duplication on the X chromosome. The encoded protein may be a nuclear protein that is localized to the nucleolus, and has some similarity to a synaptonemal complex protein. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)7.11533721
2sperm motility (GO:0030317)7.01462484
3tachykinin receptor signaling pathway (GO:0007217)6.18786523
4regulation of female gonad development (GO:2000194)6.15556826
5regulation of sarcomere organization (GO:0060297)5.25774777
6fusion of sperm to egg plasma membrane (GO:0007342)5.21374292
7sperm capacitation (GO:0048240)5.07447607
8multicellular organism reproduction (GO:0032504)4.85018903
9microtubule depolymerization (GO:0007019)4.80348092
10calcium ion-dependent exocytosis (GO:0017156)4.73198181
11G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.72945483
12spermatid development (GO:0007286)4.65752186
13negative regulation of translation, ncRNA-mediated (GO:0040033)4.63972064
14regulation of translation, ncRNA-mediated (GO:0045974)4.63972064
15negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.63972064
16cellular ketone body metabolic process (GO:0046950)4.61200943
17microtubule polymerization or depolymerization (GO:0031109)4.55321955
18monoubiquitinated protein deubiquitination (GO:0035520)4.45332392
19protein polyglutamylation (GO:0018095)4.43584677
20microtubule severing (GO:0051013)4.42109459
21sperm-egg recognition (GO:0035036)4.41068013
22response to pheromone (GO:0019236)4.20093491
23negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.16280811
24NAD biosynthetic process (GO:0009435)4.14046128
25ketone body metabolic process (GO:1902224)4.06048037
26single strand break repair (GO:0000012)4.02465043
27peptidyl-threonine dephosphorylation (GO:0035970)3.98431266
28phosphatidylethanolamine biosynthetic process (GO:0006646)3.94376009
29plasma membrane fusion (GO:0045026)3.94343072
30establishment of protein localization to Golgi (GO:0072600)3.91176933
31DNA packaging (GO:0006323)3.90057861
32nucleoside diphosphate catabolic process (GO:0009134)3.88950631
33reproduction (GO:0000003)3.88016800
34chromosome condensation (GO:0030261)3.87945083
35positive regulation of digestive system process (GO:0060456)3.83888485
36cilium or flagellum-dependent cell motility (GO:0001539)3.82561599
37cranial nerve morphogenesis (GO:0021602)3.82169884
38positive regulation of action potential (GO:0045760)3.77497847
39response to misfolded protein (GO:0051788)3.75555618
40cell-cell recognition (GO:0009988)3.73465979
41regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.70066297
42spermatid nucleus differentiation (GO:0007289)3.69517338
43binding of sperm to zona pellucida (GO:0007339)3.68868966
44male gamete generation (GO:0048232)3.66572767
45spermatogenesis (GO:0007283)3.66247429
46phosphatidylethanolamine metabolic process (GO:0046337)3.64915210
47gonadal mesoderm development (GO:0007506)3.52076432
48protein targeting to Golgi (GO:0000042)3.49210249
49gamete generation (GO:0007276)3.45573341
50negative regulation of inclusion body assembly (GO:0090084)3.44478944
51cellular response to pH (GO:0071467)3.43783352
52axonemal dynein complex assembly (GO:0070286)3.39401723
53mesenchymal cell differentiation involved in renal system development (GO:2001012)3.36775275
54mesenchymal cell differentiation involved in kidney development (GO:0072161)3.36775275
55retrograde transport, vesicle recycling within Golgi (GO:0000301)3.33477581
56sex differentiation (GO:0007548)3.32964900
57regulation of retinoic acid receptor signaling pathway (GO:0048385)3.31972500
58protein K63-linked deubiquitination (GO:0070536)3.28228969
59detection of light stimulus involved in visual perception (GO:0050908)3.26290243
60detection of light stimulus involved in sensory perception (GO:0050962)3.26290243
61prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.25574044
62righting reflex (GO:0060013)3.24832089
63regulation of cilium movement (GO:0003352)3.22523449
64reflex (GO:0060004)3.19805437
65chemosensory behavior (GO:0007635)3.19685135
66cell differentiation involved in metanephros development (GO:0072202)3.13303585
67male meiosis I (GO:0007141)3.12540697
68motile cilium assembly (GO:0044458)3.12038390
69protein K48-linked deubiquitination (GO:0071108)3.11379262
70membrane depolarization during action potential (GO:0086010)3.11142881
71nicotinamide nucleotide biosynthetic process (GO:0019359)3.08709228
72pyridine nucleotide biosynthetic process (GO:0019363)3.08709228
73regulation of action potential (GO:0098900)3.07379105
74seminiferous tubule development (GO:0072520)3.03829996
75single fertilization (GO:0007338)3.02881625
76regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.02826908
77positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.02826908
78chromatin silencing (GO:0006342)2.95436233
79regulation of transcription involved in cell fate commitment (GO:0060850)2.95375881
80dendritic spine morphogenesis (GO:0060997)2.94737609
81indole-containing compound catabolic process (GO:0042436)2.92887031
82indolalkylamine catabolic process (GO:0046218)2.92887031
83tryptophan catabolic process (GO:0006569)2.92887031
84indolalkylamine metabolic process (GO:0006586)2.91927825
85gamma-aminobutyric acid signaling pathway (GO:0007214)2.91811152
86coenzyme catabolic process (GO:0009109)2.90703471
87cilium movement (GO:0003341)2.90692603
88regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.90669339
89positive regulation of steroid hormone secretion (GO:2000833)2.89177067
90centriole replication (GO:0007099)2.87864269
91kynurenine metabolic process (GO:0070189)2.85929796
92vocalization behavior (GO:0071625)2.83129420
93alanine transport (GO:0032328)2.82928338
94primary amino compound metabolic process (GO:1901160)2.82581572
95postsynaptic membrane organization (GO:0001941)2.82215997
96regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.81338073
97positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.81338073
98musculoskeletal movement (GO:0050881)2.80823646
99multicellular organismal movement (GO:0050879)2.80823646
100centriole assembly (GO:0098534)2.78996751

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.76171509
2DROSHA_22980978_ChIP-Seq_HELA_Human3.04804930
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.63548846
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.62615271
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.61095142
6VDR_22108803_ChIP-Seq_LS180_Human2.44019396
7CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17627860
8POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.09766736
9TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09766736
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.09575262
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07906628
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.03113055
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97099110
14AR_21572438_ChIP-Seq_LNCaP_Human1.93561736
15GBX2_23144817_ChIP-Seq_PC3_Human1.89521221
16BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80221991
17ZNF274_21170338_ChIP-Seq_K562_Hela1.79783369
18REST_21632747_ChIP-Seq_MESCs_Mouse1.75646273
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.73420521
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.72040416
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.68088790
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67966633
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62400697
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58672171
25ER_23166858_ChIP-Seq_MCF-7_Human1.50994801
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47286984
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43412838
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43235701
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42623920
30SMAD4_21799915_ChIP-Seq_A2780_Human1.42551257
31P300_19829295_ChIP-Seq_ESCs_Human1.41073096
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40625893
33FUS_26573619_Chip-Seq_HEK293_Human1.40503926
34STAT3_23295773_ChIP-Seq_U87_Human1.40445161
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39384119
36RNF2_27304074_Chip-Seq_NSC_Mouse1.38343191
37CBP_20019798_ChIP-Seq_JUKART_Human1.38265155
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38265155
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37466605
40AR_25329375_ChIP-Seq_VCAP_Human1.36237250
41TAF15_26573619_Chip-Seq_HEK293_Human1.33145025
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32774516
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32774516
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.32444355
45TCF4_23295773_ChIP-Seq_U87_Human1.31524756
46SMAD4_21741376_ChIP-Seq_EPCs_Human1.30209231
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29568108
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29309161
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28867592
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25677036
51SMAD4_21741376_ChIP-Seq_HESCs_Human1.24727586
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23645118
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23579440
54ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22917083
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.22390933
56BCAT_22108803_ChIP-Seq_LS180_Human1.22091563
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21620420
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21526082
59TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21261533
60MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19495379
61OCT4_20526341_ChIP-Seq_ESCs_Human1.19024391
62SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18673908
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17665736
64CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16610027
65TDRD3_21172665_ChIP-Seq_MCF-7_Human1.16533405
66SMAD3_21741376_ChIP-Seq_ESCs_Human1.16420288
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.16065806
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.16010895
69ERA_21632823_ChIP-Seq_H3396_Human1.14463755
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13610678
71RUNX2_22187159_ChIP-Seq_PCA_Human1.13500615
72WDR5_24793694_ChIP-Seq_LNCAP_Human1.09995952
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09490204
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08649878
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.07372509
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07085745
77TBL1_22424771_ChIP-Seq_293T_Human1.06735784
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06334234
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06333379
80CTCF_27219007_Chip-Seq_Bcells_Human1.05470274
81KDM2B_26808549_Chip-Seq_REH_Human1.05414295
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05335018
83NANOG_20526341_ChIP-Seq_ESCs_Human1.03844534
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00666187
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00375640
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00042304
87REST_18959480_ChIP-ChIP_MESCs_Mouse0.99823406
88NFYA_21822215_ChIP-Seq_K562_Human0.99298549
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97896922
90PIAS1_25552417_ChIP-Seq_VCAP_Human0.97362586
91OCT1_27270436_Chip-Seq_PROSTATE_Human0.97214956
92GATA3_21878914_ChIP-Seq_MCF-7_Human0.96963854
93RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95905938
94NFYB_21822215_ChIP-Seq_K562_Human0.95371608
95IGF1R_20145208_ChIP-Seq_DFB_Human0.95012582
96MYC_19829295_ChIP-Seq_ESCs_Human0.94858587
97AR_19668381_ChIP-Seq_PC3_Human0.94211219
98ETV1_20927104_ChIP-Seq_GIST48_Human0.94082512
99E2F1_20622854_ChIP-Seq_HELA_Human0.93305557
100GATA1_26923725_Chip-Seq_HPCs_Mouse0.93211734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.69159656
2MP0005377_hearing/vestibular/ear_phenot4.03594314
3MP0003878_abnormal_ear_physiology4.03594314
4MP0005670_abnormal_white_adipose4.00090481
5MP0001501_abnormal_sleep_pattern3.08612648
6MP0002822_catalepsy3.03747816
7MP0005423_abnormal_somatic_nervous2.73463946
8MP0002735_abnormal_chemical_nociception2.59978783
9MP0006292_abnormal_olfactory_placode2.55789439
10MP0003698_abnormal_male_reproductive2.49950991
11MP0009745_abnormal_behavioral_response2.39373877
12MP0001486_abnormal_startle_reflex2.31030261
13MP0001485_abnormal_pinna_reflex2.22139811
14MP0001905_abnormal_dopamine_level2.18659467
15MP0001968_abnormal_touch/_nociception2.12053212
16MP0001348_abnormal_lacrimal_gland2.10639424
17MP0006276_abnormal_autonomic_nervous2.09247605
18MP0001929_abnormal_gametogenesis2.08114353
19MP0002733_abnormal_thermal_nociception2.07323084
20MP0001440_abnormal_grooming_behavior2.05497967
21MP0003195_calcinosis2.01678626
22MP0009046_muscle_twitch1.96252027
23MP0010386_abnormal_urinary_bladder1.89495523
24MP0002249_abnormal_larynx_morphology1.85123038
25MP0002572_abnormal_emotion/affect_behav1.82591925
26MP0003718_maternal_effect1.73231578
27MP0000678_abnormal_parathyroid_gland1.71015077
28MP0001970_abnormal_pain_threshold1.70621390
29MP0003635_abnormal_synaptic_transmissio1.70245070
30MP0000026_abnormal_inner_ear1.60718118
31MP0005551_abnormal_eye_electrophysiolog1.58771512
32MP0001963_abnormal_hearing_physiology1.56886257
33MP0002272_abnormal_nervous_system1.54471728
34MP0003646_muscle_fatigue1.52312216
35MP0003879_abnormal_hair_cell1.50182335
36MP0002234_abnormal_pharynx_morphology1.42794612
37MP0002067_abnormal_sensory_capabilities1.42074883
38MP0002161_abnormal_fertility/fecundity1.41112283
39MP0002210_abnormal_sex_determination1.40169437
40MP0004859_abnormal_synaptic_plasticity1.39095706
41MP0002736_abnormal_nociception_after1.38696897
42MP0002734_abnormal_mechanical_nocicepti1.38327211
43MP0005645_abnormal_hypothalamus_physiol1.36952041
44MP0002557_abnormal_social/conspecific_i1.36563543
45MP0002064_seizures1.34290345
46MP0005647_abnormal_sex_gland1.30898789
47MP0004142_abnormal_muscle_tone1.29870908
48MP0002928_abnormal_bile_duct1.28326432
49MP0000653_abnormal_sex_gland1.21530788
50MP0003880_abnormal_central_pattern1.20779904
51MP0004742_abnormal_vestibular_system1.18300118
52MP0005171_absent_coat_pigmentation1.15966799
53MP0001765_abnormal_ion_homeostasis1.14654041
54MP0000049_abnormal_middle_ear1.12985478
55MP0001145_abnormal_male_reproductive1.11773466
56MP0008569_lethality_at_weaning1.09668084
57MP0003252_abnormal_bile_duct1.09209815
58MP0002063_abnormal_learning/memory/cond1.08360970
59MP0008872_abnormal_physiological_respon1.07473058
60MP0003011_delayed_dark_adaptation1.07150645
61MP0003119_abnormal_digestive_system1.05648091
62MP0005646_abnormal_pituitary_gland1.01496352
63MP0002229_neurodegeneration1.00665821
64MP0005253_abnormal_eye_physiology0.99555949
65MP0000534_abnormal_ureter_morphology0.98994439
66MP0004885_abnormal_endolymph0.96888891
67MP0005395_other_phenotype0.96397826
68MP0003283_abnormal_digestive_organ0.94883109
69MP0008057_abnormal_DNA_replication0.94593793
70MP0002184_abnormal_innervation0.91805778
71MP0002653_abnormal_ependyma_morphology0.91706533
72MP0000639_abnormal_adrenal_gland0.90050199
73MP0000631_abnormal_neuroendocrine_gland0.88968920
74MP0000955_abnormal_spinal_cord0.88153471
75MP0002752_abnormal_somatic_nervous0.86759954
76MP0000470_abnormal_stomach_morphology0.85567530
77MP0005084_abnormal_gallbladder_morpholo0.85277145
78MP0003942_abnormal_urinary_system0.79817541
79MP0000681_abnormal_thyroid_gland0.79586865
80MP0002882_abnormal_neuron_morphology0.78940794
81MP0000778_abnormal_nervous_system0.76234665
82MP0009697_abnormal_copulation0.75632934
83MP0001986_abnormal_taste_sensitivity0.73484427
84MP0008877_abnormal_DNA_methylation0.72228011
85MP0001879_abnormal_lymphatic_vessel0.71783226
86MP0004085_abnormal_heartbeat0.70134746
87MP0001529_abnormal_vocalization0.67695451
88MP0002138_abnormal_hepatobiliary_system0.67653122
89MP0005083_abnormal_biliary_tract0.66578410
90MP0001984_abnormal_olfaction0.66517887
91MP0002066_abnormal_motor_capabilities/c0.62851197
92MP0003943_abnormal_hepatobiliary_system0.62702536
93MP0002638_abnormal_pupillary_reflex0.61258723
94MP0002168_other_aberrant_phenotype0.60256841
95MP0003045_fibrosis0.58611492
96MP0008995_early_reproductive_senescence0.58458002
97MP0005195_abnormal_posterior_eye0.57681428
98MP0004145_abnormal_muscle_electrophysio0.57384881
99MP0001188_hyperpigmentation0.57270009
100MP0000230_abnormal_systemic_arterial0.56247233

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)8.57090931
2Progressive cerebellar ataxia (HP:0002073)6.86136381
3Severe visual impairment (HP:0001141)5.72319700
4Abnormality of macular pigmentation (HP:0008002)5.10926142
5Dysmetric saccades (HP:0000641)4.58307237
6Retinal dysplasia (HP:0007973)4.35391415
7Gaze-evoked nystagmus (HP:0000640)4.24723087
8Decreased central vision (HP:0007663)4.22420483
9Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.11065988
10Hypoplastic ischia (HP:0003175)4.00352146
11Bony spicule pigmentary retinopathy (HP:0007737)3.87207039
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.80031034
13Absent/shortened dynein arms (HP:0200106)3.80031034
14Attenuation of retinal blood vessels (HP:0007843)3.79132747
15Abnormality of the ischium (HP:0003174)3.48835812
16Abnormality of binocular vision (HP:0011514)3.48773910
17Diplopia (HP:0000651)3.48773910
18Postural instability (HP:0002172)3.44451989
19Focal motor seizures (HP:0011153)3.30392911
20Abnormal ciliary motility (HP:0012262)3.23201714
21Congenital stationary night blindness (HP:0007642)3.20331043
22Bell-shaped thorax (HP:0001591)3.16621630
23Hypoplasia of the iris (HP:0007676)3.10931302
24Potter facies (HP:0002009)3.06251698
25Facial shape deformation (HP:0011334)3.06251698
26Abnormal rod and cone electroretinograms (HP:0008323)3.03291352
27Impaired smooth pursuit (HP:0007772)2.97302216
28Proximal tubulopathy (HP:0000114)2.96849897
29Male infertility (HP:0003251)2.87502378
30Urinary bladder sphincter dysfunction (HP:0002839)2.86547022
31Abnormality of the pubic bones (HP:0003172)2.84764485
32Abnormal respiratory motile cilium physiology (HP:0012261)2.84759730
33Hyperventilation (HP:0002883)2.80268527
34Hyperkalemia (HP:0002153)2.79906040
35Sclerocornea (HP:0000647)2.76649043
36Congenital sensorineural hearing impairment (HP:0008527)2.76309622
37Nephronophthisis (HP:0000090)2.69758318
38Absence seizures (HP:0002121)2.60480252
39Myokymia (HP:0002411)2.58337195
40Focal seizures (HP:0007359)2.58088535
41Dialeptic seizures (HP:0011146)2.56250069
42Abnormal respiratory motile cilium morphology (HP:0005938)2.56042972
43Abnormal respiratory epithelium morphology (HP:0012253)2.56042972
44Action tremor (HP:0002345)2.50827673
45Narrow nasal bridge (HP:0000446)2.47372968
46Abnormal drinking behavior (HP:0030082)2.44802944
47Polydipsia (HP:0001959)2.44802944
48Febrile seizures (HP:0002373)2.38986114
49Abnormality of the diencephalon (HP:0010662)2.36567019
50Chronic hepatic failure (HP:0100626)2.34751709
51Infertility (HP:0000789)2.30036281
52Hypophosphatemic rickets (HP:0004912)2.28352530
53Abnormality of the renal medulla (HP:0100957)2.26420205
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.23350112
55Abnormality of ocular smooth pursuit (HP:0000617)2.21466586
56Pendular nystagmus (HP:0012043)2.20174691
57Macular degeneration (HP:0000608)2.10318534
58Abnormality of the aortic arch (HP:0012303)2.08423682
59Central scotoma (HP:0000603)2.07642594
60Prostate neoplasm (HP:0100787)2.05766104
61Cone-rod dystrophy (HP:0000548)2.05252170
62Clumsiness (HP:0002312)2.01293686
63Bicornuate uterus (HP:0000813)2.00331766
64Keratoconus (HP:0000563)2.00136002
65Increased corneal curvature (HP:0100692)2.00136002
66Stereotypic behavior (HP:0000733)1.98969654
67Abnormality of the hepatic vasculature (HP:0006707)1.97585552
68Impulsivity (HP:0100710)1.96882472
69Polyuria (HP:0000103)1.96444499
70Tubulointerstitial nephritis (HP:0001970)1.95364872
71Abnormal urine output (HP:0012590)1.94987360
72Impaired vibratory sensation (HP:0002495)1.94777821
73Abnormality of the anterior chamber (HP:0000593)1.94474843
74Truncal obesity (HP:0001956)1.92395909
75Dysautonomia (HP:0002459)1.91207367
76Renal dysplasia (HP:0000110)1.90220221
77Pancreatic cysts (HP:0001737)1.89583239
78Areflexia of lower limbs (HP:0002522)1.89314681
79Rhinitis (HP:0012384)1.88400075
80Scotoma (HP:0000575)1.86794973
81Enlarged epiphyses (HP:0010580)1.86221757
82Aplasia/Hypoplasia of the fovea (HP:0008060)1.85465114
83Hypoplasia of the fovea (HP:0007750)1.85465114
84Hemiparesis (HP:0001269)1.84693176
85Abnormality of the vitreous humor (HP:0004327)1.81935151
86Pancreatic fibrosis (HP:0100732)1.78182981
87Intellectual disability, progressive (HP:0006887)1.76973049
88Abnormality of potassium homeostasis (HP:0011042)1.74943905
89Azoospermia (HP:0000027)1.70801801
90Renovascular hypertension (HP:0100817)1.68274981
91Autoimmune thrombocytopenia (HP:0001973)1.66788256
92Abnormality of midbrain morphology (HP:0002418)1.66746282
93Molar tooth sign on MRI (HP:0002419)1.66746282
94Abolished electroretinogram (ERG) (HP:0000550)1.65238265
95Protruding tongue (HP:0010808)1.63612592
96Atonic seizures (HP:0010819)1.63121055
97Preauricular pit (HP:0004467)1.63006467
98Periauricular skin pits (HP:0100277)1.63006467
99Abnormality of renal excretion (HP:0011036)1.61941256
100Recurrent pneumonia (HP:0006532)1.59916456

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.05380889
2FRK5.51031070
3PLK43.17838062
4DDR23.03652255
5SIK22.77613385
6BMPR1B2.38110306
7STK382.34635637
8CAMK1G2.24742537
9STK38L2.23609143
10CDK192.12881261
11TAOK31.90682784
12ACVR1B1.85088889
13PNCK1.84710208
14NTRK31.83320893
15CDK121.81148954
16TNK21.76786346
17TESK11.74001237
18OXSR11.73930559
19MAPK151.70482310
20CAMK1D1.65174014
21LATS11.60062323
22NUAK11.54963160
23MAP4K21.54611890
24GRK11.54361043
25ADRBK21.49820560
26PRKD31.46547683
27CDC71.37414722
28MAPK131.30734186
29PRKCE1.20946450
30MAP3K41.19202363
31BCKDK1.13897930
32ADRBK11.08879541
33NEK21.03245186
34NEK61.02252249
35KIT0.98059127
36PINK10.98015206
37CASK0.96263272
38CDK70.95878428
39PRKCG0.95590801
40STK390.93371646
41MAP3K70.90507373
42WNK10.85816888
43ZAK0.81900227
44CAMK10.80875846
45BRD40.79830938
46MKNK20.78532916
47GRK70.76384228
48CAMK40.75822097
49PKN10.75613905
50PTK2B0.74023732
51TAOK10.71465612
52WNK40.70145359
53CDK30.67982367
54PLK20.67347399
55PASK0.67130332
56PRKG10.66883248
57PRKCH0.66701779
58MST1R0.63749221
59CAMKK10.63323717
60PRKG20.62909860
61DAPK20.59889857
62PRKAA20.59180913
63CDK40.57948421
64GSK3B0.57400230
65MAP2K70.56115906
66WNK30.54980999
67STK110.54895712
68MARK10.54787639
69ICK0.53056933
70CSNK1A10.50222188
71CAMK2A0.49872411
72STK30.48987653
73PDPK10.48351522
74PRKAA10.48277564
75MAP2K60.46430267
76UHMK10.46429709
77CDK20.45575267
78TGFBR10.45205875
79RPS6KA10.43591451
80CHEK20.42328712
81MAP3K90.42247905
82PRKACA0.41664237
83MTOR0.41113675
84MAPK80.40482542
85PRKCA0.40331523
86CDK10.40135933
87TAF10.38899098
88SGK10.37461122
89TEC0.37103115
90PDK10.36700796
91MARK20.35968630
92RPS6KA60.34959698
93TIE10.34064924
94MAPK10.33206513
95MAP3K110.32370921
96PRKCB0.32348676
97NTRK20.31277579
98AKT30.30542403
99MATK0.29741621
100MAP2K40.27780760

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.00575533
2Taste transduction_Homo sapiens_hsa047423.31587119
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.24165368
4Morphine addiction_Homo sapiens_hsa050322.97046217
5Fatty acid biosynthesis_Homo sapiens_hsa000612.95546465
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.89536532
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.65566607
8Olfactory transduction_Homo sapiens_hsa047402.50922993
9GABAergic synapse_Homo sapiens_hsa047272.42604288
10Butanoate metabolism_Homo sapiens_hsa006502.40836166
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.22983137
12Glutamatergic synapse_Homo sapiens_hsa047242.08035098
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99389783
14Phototransduction_Homo sapiens_hsa047441.98431884
15Circadian entrainment_Homo sapiens_hsa047131.92405024
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.87985726
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.76883502
18Serotonergic synapse_Homo sapiens_hsa047261.66562685
19Insulin secretion_Homo sapiens_hsa049111.64149184
20Calcium signaling pathway_Homo sapiens_hsa040201.48999911
21Sulfur relay system_Homo sapiens_hsa041221.45967675
22Salivary secretion_Homo sapiens_hsa049701.43389996
23Gastric acid secretion_Homo sapiens_hsa049711.37832736
24Cocaine addiction_Homo sapiens_hsa050301.37515133
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36689011
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.36015742
27Selenocompound metabolism_Homo sapiens_hsa004501.33846014
28Cholinergic synapse_Homo sapiens_hsa047251.32647480
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.32099436
30Dorso-ventral axis formation_Homo sapiens_hsa043201.29580227
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.24509610
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.24255249
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22165637
34Retinol metabolism_Homo sapiens_hsa008301.16982392
35Linoleic acid metabolism_Homo sapiens_hsa005911.15137166
36Type II diabetes mellitus_Homo sapiens_hsa049301.08782474
37Renin secretion_Homo sapiens_hsa049241.07563846
38Homologous recombination_Homo sapiens_hsa034401.07179445
39ABC transporters_Homo sapiens_hsa020101.07146020
40Oxytocin signaling pathway_Homo sapiens_hsa049211.06866454
41cAMP signaling pathway_Homo sapiens_hsa040241.04235825
42cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97446473
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89795937
44Chemical carcinogenesis_Homo sapiens_hsa052040.88099995
45Tryptophan metabolism_Homo sapiens_hsa003800.88000580
46Dopaminergic synapse_Homo sapiens_hsa047280.87092181
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86675537
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86519107
49Ether lipid metabolism_Homo sapiens_hsa005650.86313612
50Synaptic vesicle cycle_Homo sapiens_hsa047210.83539697
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.81719661
52Glycerolipid metabolism_Homo sapiens_hsa005610.81150512
53Long-term depression_Homo sapiens_hsa047300.78728108
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76141008
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75854497
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75244776
57Purine metabolism_Homo sapiens_hsa002300.73716711
58Ovarian steroidogenesis_Homo sapiens_hsa049130.71704985
59Hedgehog signaling pathway_Homo sapiens_hsa043400.70406710
60Lysine degradation_Homo sapiens_hsa003100.69730061
61Estrogen signaling pathway_Homo sapiens_hsa049150.64841852
62Bile secretion_Homo sapiens_hsa049760.62296099
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58839923
64Sphingolipid metabolism_Homo sapiens_hsa006000.58789349
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.56052118
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54959654
67Basal transcription factors_Homo sapiens_hsa030220.54863586
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54697906
69Caffeine metabolism_Homo sapiens_hsa002320.52813829
70Nitrogen metabolism_Homo sapiens_hsa009100.51145981
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50168779
72Protein digestion and absorption_Homo sapiens_hsa049740.50078074
73Fatty acid degradation_Homo sapiens_hsa000710.45065086
74Fanconi anemia pathway_Homo sapiens_hsa034600.44404913
75MAPK signaling pathway_Homo sapiens_hsa040100.43793274
76PPAR signaling pathway_Homo sapiens_hsa033200.43420772
77Oocyte meiosis_Homo sapiens_hsa041140.42580274
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42088707
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.41123074
80Cardiac muscle contraction_Homo sapiens_hsa042600.40896219
81Pancreatic secretion_Homo sapiens_hsa049720.40211519
82Platelet activation_Homo sapiens_hsa046110.40058411
83Type I diabetes mellitus_Homo sapiens_hsa049400.38671853
84Propanoate metabolism_Homo sapiens_hsa006400.35661904
85Renin-angiotensin system_Homo sapiens_hsa046140.33981536
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33286121
87Arginine and proline metabolism_Homo sapiens_hsa003300.33181593
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32431319
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31280535
90Arachidonic acid metabolism_Homo sapiens_hsa005900.30791822
91Regulation of autophagy_Homo sapiens_hsa041400.30511984
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.28250440
93Basal cell carcinoma_Homo sapiens_hsa052170.28018019
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27960322
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27908565
96mRNA surveillance pathway_Homo sapiens_hsa030150.27865440
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27416146
98Amphetamine addiction_Homo sapiens_hsa050310.26110664
99Notch signaling pathway_Homo sapiens_hsa043300.25909953
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.24766277

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