FAN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene plays a role in DNA interstrand cross-link repair and encodes a protein with 5' flap endonuclease and 5'-3' exonuclease activity. Mutations in this gene cause karyomegalic interstitial nephritis. Alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.60132324
2axon ensheathment in central nervous system (GO:0032291)9.60132324
3fatty acid elongation (GO:0030497)5.57790586
4ensheathment of neurons (GO:0007272)5.13436584
5axon ensheathment (GO:0008366)5.13436584
6myelination (GO:0042552)5.11974479
7nuclear pore complex assembly (GO:0051292)4.97507143
8long-chain fatty acid biosynthetic process (GO:0042759)4.92242257
9presynaptic membrane organization (GO:0097090)4.89075413
10presynaptic membrane assembly (GO:0097105)4.85797042
11nuclear pore organization (GO:0006999)4.31000693
12limb bud formation (GO:0060174)4.21853403
13negative regulation of protein localization to cell surface (GO:2000009)4.14600861
14oligodendrocyte differentiation (GO:0048709)4.11571182
15negative regulation of neurotransmitter secretion (GO:0046929)4.02993967
16negative regulation of neurotransmitter transport (GO:0051589)3.97831741
17myelin maintenance (GO:0043217)3.94962204
18L-amino acid import (GO:0043092)3.93701757
19import into cell (GO:0098657)3.89376660
20regulation of collateral sprouting (GO:0048670)3.88690148
21mitotic sister chromatid cohesion (GO:0007064)3.80151444
22positive regulation of oligodendrocyte differentiation (GO:0048714)3.73755387
23DNA double-strand break processing (GO:0000729)3.71239242
24neuron remodeling (GO:0016322)3.71078217
25negative regulation of synaptic transmission, GABAergic (GO:0032229)3.67366048
26neuron cell-cell adhesion (GO:0007158)3.66757339
27eye photoreceptor cell differentiation (GO:0001754)3.62070854
28photoreceptor cell differentiation (GO:0046530)3.62070854
29astrocyte development (GO:0014002)3.58614324
30glycerophospholipid catabolic process (GO:0046475)3.56874123
31pore complex assembly (GO:0046931)3.53134771
32cerebral cortex radially oriented cell migration (GO:0021799)3.48701538
33positive regulation of action potential (GO:0045760)3.46940726
34transmission of nerve impulse (GO:0019226)3.30928296
35peptidyl-lysine dimethylation (GO:0018027)3.25974300
36response to redox state (GO:0051775)3.15865348
37negative regulation of execution phase of apoptosis (GO:1900118)3.14524905
38DNA unwinding involved in DNA replication (GO:0006268)3.11339690
39lateral sprouting from an epithelium (GO:0060601)3.09820568
40neuronal action potential propagation (GO:0019227)3.06320330
41asymmetric protein localization (GO:0008105)2.99236011
42organ growth (GO:0035265)2.97449493
43myelination in peripheral nervous system (GO:0022011)2.97078432
44peripheral nervous system axon ensheathment (GO:0032292)2.97078432
45dosage compensation (GO:0007549)2.96459235
46response to methylmercury (GO:0051597)2.95458455
47cholesterol biosynthetic process (GO:0006695)2.95301824
48short-term memory (GO:0007614)2.90888115
49pre-miRNA processing (GO:0031054)2.87981923
50amino acid import (GO:0043090)2.87449912
51GPI anchor metabolic process (GO:0006505)2.86209257
52creatine metabolic process (GO:0006600)2.85045990
53protein palmitoylation (GO:0018345)2.84540751
54translesion synthesis (GO:0019985)2.84529313
55amyloid precursor protein metabolic process (GO:0042982)2.84042088
56positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.84013410
57isoprenoid biosynthetic process (GO:0008299)2.82373076
58peptidyl-tyrosine autophosphorylation (GO:0038083)2.80505622
59negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.80186028
60GPI anchor biosynthetic process (GO:0006506)2.78845301
61regulation of centriole replication (GO:0046599)2.77590666
62retina layer formation (GO:0010842)2.77186995
63adult walking behavior (GO:0007628)2.75699879
64response to lipoprotein particle (GO:0055094)2.75033180
65DNA replication initiation (GO:0006270)2.74168487
66apical protein localization (GO:0045176)2.74020933
67positive regulation of cellular amine metabolic process (GO:0033240)2.73608121
68spliceosomal tri-snRNP complex assembly (GO:0000244)2.70193172
69establishment of mitochondrion localization (GO:0051654)2.69920499
70regulation of RNA export from nucleus (GO:0046831)2.69026848
71postsynaptic membrane organization (GO:0001941)2.68926238
72inositol metabolic process (GO:0006020)2.68008029
73nucleotide transmembrane transport (GO:1901679)2.68005998
74cranial nerve development (GO:0021545)2.65371858
75keratinocyte development (GO:0003334)2.62889369
76cytoplasmic mRNA processing body assembly (GO:0033962)2.62747096
77cranial nerve morphogenesis (GO:0021602)2.62517700
78regulation of somitogenesis (GO:0014807)2.60635711
79negative regulation of exocytosis (GO:0045920)2.60160088
80cellular response to epinephrine stimulus (GO:0071872)2.59323633
81regulation of histone H3-K9 methylation (GO:0051570)2.59301500
82nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.58785920
83membrane assembly (GO:0071709)2.58213544
84gamma-aminobutyric acid signaling pathway (GO:0007214)2.58173648
85L-serine metabolic process (GO:0006563)2.56798296
86embryonic retina morphogenesis in camera-type eye (GO:0060059)2.56088134
87positive regulation of glial cell differentiation (GO:0045687)2.54125343
88negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.53993296
89generation of neurons (GO:0048699)2.53572034
90regulation of glutamate secretion (GO:0014048)2.53472037
91DNA duplex unwinding (GO:0032508)2.53199977
92DNA geometric change (GO:0032392)2.52860622
93regulation of pigment cell differentiation (GO:0050932)2.52849943
94glycine transport (GO:0015816)2.51139711
95mitotic chromosome condensation (GO:0007076)2.51038511
96preassembly of GPI anchor in ER membrane (GO:0016254)2.50178621
97negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.49407770
98sterol biosynthetic process (GO:0016126)2.48043218
99negative regulation of cytosolic calcium ion concentration (GO:0051481)2.47439751
100positive regulation of dendritic spine morphogenesis (GO:0061003)2.46604956
101neuron recognition (GO:0008038)2.46547688
102long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.45927376
103response to epinephrine (GO:0071871)2.45715191
104peptidyl-proline hydroxylation (GO:0019511)2.45006394
105positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.44229588
106positive regulation of protein kinase C signaling (GO:0090037)2.43068818
107glial cell development (GO:0021782)2.42700786
108double-strand break repair via nonhomologous end joining (GO:0006303)2.42663630
109non-recombinational repair (GO:0000726)2.42663630
110startle response (GO:0001964)2.42229468
111negative regulation of axon extension (GO:0030517)2.42196128
112cranial nerve structural organization (GO:0021604)2.41981238
113negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.40880451
114histone H3-K9 methylation (GO:0051567)2.40814533
115substantia nigra development (GO:0021762)2.40485401
116enteric nervous system development (GO:0048484)2.40295670
117regulation of skeletal muscle cell differentiation (GO:2001014)2.39999633
118axon development (GO:0061564)2.39634194
119histone H2B ubiquitination (GO:0033523)2.38951741
120glutamine metabolic process (GO:0006541)2.38775591
121regulation of centrosome duplication (GO:0010824)2.38525296
122negative regulation of Rho protein signal transduction (GO:0035024)2.38276390
123negative regulation of synaptic transmission (GO:0050805)2.38276118
124histone H3-K9 demethylation (GO:0033169)2.38255855
125positive regulation of synapse assembly (GO:0051965)2.37521946
126histone H3-K36 demethylation (GO:0070544)2.36428357
127establishment of nucleus localization (GO:0040023)2.36388794
128detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.36303430
129regulation of oligodendrocyte differentiation (GO:0048713)2.36142067
130long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.35895222
131negative regulation of axonogenesis (GO:0050771)2.35761295
132negative regulation of potassium ion transmembrane transport (GO:1901380)2.35601987
133carnitine transmembrane transport (GO:1902603)2.35419722
134glial cell differentiation (GO:0010001)2.34283350
135regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.33984650
136neuronal ion channel clustering (GO:0045161)2.32893047
137negative regulation of mRNA metabolic process (GO:1903312)2.32883540
138histone lysine demethylation (GO:0070076)2.32558879
1394-hydroxyproline metabolic process (GO:0019471)2.32459989
140otic vesicle formation (GO:0030916)2.32309869
141neural tube formation (GO:0001841)2.31791263
142cyclic nucleotide catabolic process (GO:0009214)2.31627538
143regulation of timing of cell differentiation (GO:0048505)2.30983736
144establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.29858857
145mitochondrion transport along microtubule (GO:0047497)2.29858857
146spinal cord motor neuron differentiation (GO:0021522)2.29104586
147cerebellar granule cell differentiation (GO:0021707)2.28797987
148histone demethylation (GO:0016577)2.28420303
149regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.28341007
150labyrinthine layer development (GO:0060711)2.27983487
151lysine metabolic process (GO:0006553)2.27843947
152lysine catabolic process (GO:0006554)2.27843947
153peripheral nervous system development (GO:0007422)2.27813633
154regulation of translational fidelity (GO:0006450)2.27355897
155mRNA splice site selection (GO:0006376)2.24350480
156regulation of DNA endoreduplication (GO:0032875)2.24206274
157layer formation in cerebral cortex (GO:0021819)2.23711252
158regulation of relaxation of muscle (GO:1901077)2.23601466
159stress granule assembly (GO:0034063)2.23505084
160gene silencing by RNA (GO:0031047)2.23149696
161negative regulation of DNA recombination (GO:0045910)2.22356049
162protein hydroxylation (GO:0018126)2.21807539
163negative regulation of histone methylation (GO:0031061)2.20783512
164paraxial mesoderm development (GO:0048339)2.20048806
165negative regulation of mRNA processing (GO:0050686)2.20028723
166DNA strand elongation involved in DNA replication (GO:0006271)2.18738043
167glial cell proliferation (GO:0014009)2.17054109
168nucleus localization (GO:0051647)2.13745401
169phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.11719887
170telomere maintenance via semi-conservative replication (GO:0032201)2.11204474
171axonal fasciculation (GO:0007413)2.11059251
172actin-myosin filament sliding (GO:0033275)2.10470927
173muscle filament sliding (GO:0030049)2.10470927
174regulation of nucleobase-containing compound transport (GO:0032239)2.09135331
175regulation of centrosome cycle (GO:0046605)2.08590098
176nucleosome disassembly (GO:0006337)2.08019964
177protein-DNA complex disassembly (GO:0032986)2.08019964
178glucocorticoid receptor signaling pathway (GO:0042921)2.07540261
179morphogenesis of an epithelial sheet (GO:0002011)2.06852534
180IMP metabolic process (GO:0046040)2.06685117
181cerebral cortex development (GO:0021987)2.06442177
182amino-acid betaine transport (GO:0015838)2.05067766
183carnitine transport (GO:0015879)2.05067766
184DNA strand elongation (GO:0022616)2.05009767
185somatic diversification of immune receptors via somatic mutation (GO:0002566)2.04947263
186somatic hypermutation of immunoglobulin genes (GO:0016446)2.04947263
187postreplication repair (GO:0006301)2.04381035
188negative regulation of cell cycle G2/M phase transition (GO:1902750)2.04332575
189carnitine shuttle (GO:0006853)2.03051427
190protein dealkylation (GO:0008214)2.02822951
191protein demethylation (GO:0006482)2.02822951
192nucleus organization (GO:0006997)2.02608878
193regulation of cAMP-dependent protein kinase activity (GO:2000479)2.02024027
194histone lysine methylation (GO:0034968)2.01765970
195cardiac myofibril assembly (GO:0055003)2.01405988
196establishment of spindle orientation (GO:0051294)2.01377780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.22494923
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.86824034
3GBX2_23144817_ChIP-Seq_PC3_Human3.58225484
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.49649707
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.21134599
6EZH2_22144423_ChIP-Seq_EOC_Human2.72650891
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.50518077
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.47192688
9AR_21572438_ChIP-Seq_LNCaP_Human2.46225700
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43138352
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.42515560
12TAF15_26573619_Chip-Seq_HEK293_Human2.36355806
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.36126206
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.35769698
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35432028
16AR_21909140_ChIP-Seq_LNCAP_Human2.22927960
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22291298
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.18754699
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17517247
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17517247
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17250195
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.11194733
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10645773
24TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.02358213
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01742936
26TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.99805509
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97182919
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95222312
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.94428859
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.94344353
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88337379
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83893706
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.82775129
34HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.81868784
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81032978
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80948516
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80541079
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.78480104
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.74887975
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73327153
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73190768
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68681054
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.67930801
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67696132
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67350115
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.67038761
47P300_19829295_ChIP-Seq_ESCs_Human1.66462816
48YAP1_20516196_ChIP-Seq_MESCs_Mouse1.64951958
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64872944
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63921054
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63349100
52VDR_22108803_ChIP-Seq_LS180_Human1.62847028
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62778312
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62300897
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.61927206
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.53649137
57ER_23166858_ChIP-Seq_MCF-7_Human1.50965507
58RNF2_27304074_Chip-Seq_NSC_Mouse1.48326312
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47089932
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46352943
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46033371
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45279197
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.44839795
64DROSHA_22980978_ChIP-Seq_HELA_Human1.44163159
65SOX9_26525672_Chip-Seq_HEART_Mouse1.43749288
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.42295127
67CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41859004
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41139640
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.39979782
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.38170954
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36925586
72FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.36226397
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33797624
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.33726218
75MYC_18555785_ChIP-Seq_MESCs_Mouse1.33629629
76FUS_26573619_Chip-Seq_HEK293_Human1.33207584
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.30589138
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30532333
79EWS_26573619_Chip-Seq_HEK293_Human1.30532308
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30272118
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30143527
82SMAD4_21799915_ChIP-Seq_A2780_Human1.29654493
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.29376601
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28271656
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.28029275
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.26614372
87P300_18555785_Chip-Seq_ESCs_Mouse1.26217099
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26126401
89P53_22387025_ChIP-Seq_ESCs_Mouse1.24906004
90TP53_18474530_ChIP-ChIP_U2OS_Human1.24625252
91ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24469406
92STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.24139792
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24070843
94ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23964501
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23205820
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23152205
97CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22824137
98IRF1_19129219_ChIP-ChIP_H3396_Human1.22696993
99DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22613685
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.20955885
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20538286
102MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20372194
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19889211
104EP300_21415370_ChIP-Seq_HL-1_Mouse1.19633456
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19332786
106STAT3_18555785_Chip-Seq_ESCs_Mouse1.17733462
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15972761
108STAT3_23295773_ChIP-Seq_U87_Human1.15971011
109TAL1_26923725_Chip-Seq_HPCs_Mouse1.15302647
110ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14526264
111RUNX1_27457419_Chip-Seq_LIVER_Mouse1.13873747
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12786186
113ARNT_22903824_ChIP-Seq_MCF-7_Human1.11784604
114TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11620219
115TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10491463
116RARB_27405468_Chip-Seq_BRAIN_Mouse1.09974572
117AR_19668381_ChIP-Seq_PC3_Human1.09244511
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09089993
119TP53_16413492_ChIP-PET_HCT116_Human1.08977408
120ESR1_20079471_ChIP-ChIP_T-47D_Human1.08870852
121AHR_22903824_ChIP-Seq_MCF-7_Human1.08192404
122TCF4_23295773_ChIP-Seq_U87_Human1.07697285
123P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06983917
124SOX2_16153702_ChIP-ChIP_HESCs_Human1.06029684
125OCT4_18555785_Chip-Seq_ESCs_Mouse1.06008512
126CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05834592
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05741836
128SOX2_18555785_Chip-Seq_ESCs_Mouse1.05496091
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05423794
130KLF4_18555785_Chip-Seq_ESCs_Mouse1.05246488
131REST_21632747_ChIP-Seq_MESCs_Mouse1.05024004
132RUNX2_22187159_ChIP-Seq_PCA_Human1.05006253
133SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04946233
134CLOCK_20551151_ChIP-Seq_293T_Human1.04379409
135KDM2B_26808549_Chip-Seq_REH_Human1.03851230
136PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03112909
137NMYC_18555785_Chip-Seq_ESCs_Mouse1.03090914
138LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02286635
139SOX2_21211035_ChIP-Seq_LN229_Gbm1.01668207
140WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01529786
141RING1B_27294783_Chip-Seq_NPCs_Mouse1.01286132
142CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01011477
143POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99400165
144IGF1R_20145208_ChIP-Seq_DFB_Human0.98896533
145RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98669298
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98480587
147SMAD1_18555785_Chip-Seq_ESCs_Mouse0.98273288
148CHD1_26751641_Chip-Seq_LNCaP_Human0.97146687
149POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96568861
150CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95895973
151NANOG_16153702_ChIP-ChIP_HESCs_Human0.95347695
152EGR1_19374776_ChIP-ChIP_THP-1_Human0.95103743
153GATA4_21415370_ChIP-Seq_HL-1_Mouse0.95076693
154MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.95057004
155TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.94997082
156ISL1_27105846_Chip-Seq_CPCs_Mouse0.94292564
157FOXM1_23109430_ChIP-Seq_U2OS_Human0.94001069
158PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93848393
159NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93482123
160TCF4_18268006_ChIP-ChIP_LS174T_Human0.90882106
161CBP_20019798_ChIP-Seq_JUKART_Human0.90465538
162IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90465538
163STAT3_18555785_ChIP-Seq_MESCs_Mouse0.90405769
164RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90038311
165FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88791830
166STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87500155
167ZNF274_21170338_ChIP-Seq_K562_Hela0.87447024
168PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84248982

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.87056334
2MP0003136_yellow_coat_color4.23086983
3MP0003880_abnormal_central_pattern3.87655256
4MP0000920_abnormal_myelination3.74487167
5MP0004381_abnormal_hair_follicle3.33978095
6MP0005171_absent_coat_pigmentation2.92737098
7MP0005409_darkened_coat_color2.91394897
8MP0000566_synostosis2.84707341
9MP0004742_abnormal_vestibular_system2.77229836
10MP0001486_abnormal_startle_reflex2.70770679
11MP0003950_abnormal_plasma_membrane2.51435650
12MP0000751_myopathy2.46528148
13MP0002009_preneoplasia2.40646624
14MP0003690_abnormal_glial_cell2.30265352
15MP0002272_abnormal_nervous_system2.28237725
16MP0001529_abnormal_vocalization2.18625929
17MP0001905_abnormal_dopamine_level2.14865669
18MP0004142_abnormal_muscle_tone2.11987879
19MP0004270_analgesia2.10647784
20MP0009745_abnormal_behavioral_response2.08236000
21MP0000778_abnormal_nervous_system2.07337375
22MP0001188_hyperpigmentation2.04545532
23MP0004233_abnormal_muscle_weight2.00094841
24MP0000383_abnormal_hair_follicle1.95966610
25MP0002064_seizures1.93288864
26MP0008260_abnormal_autophagy1.91817522
27MP0001485_abnormal_pinna_reflex1.83597291
28MP0002102_abnormal_ear_morphology1.77049801
29MP0004084_abnormal_cardiac_muscle1.73100682
30MP0000747_muscle_weakness1.72752097
31MP0004885_abnormal_endolymph1.69812298
32MP0001984_abnormal_olfaction1.68195239
33MP0003938_abnormal_ear_development1.65489594
34MP0010094_abnormal_chromosome_stability1.61971919
35MP0004859_abnormal_synaptic_plasticity1.61475870
36MP0001346_abnormal_lacrimal_gland1.60954243
37MP0003121_genomic_imprinting1.57545238
38MP0001963_abnormal_hearing_physiology1.57534480
39MP0010678_abnormal_skin_adnexa1.56759479
40MP0009046_muscle_twitch1.56355099
41MP0001440_abnormal_grooming_behavior1.55510077
42MP0005551_abnormal_eye_electrophysiolog1.54244527
43MP0003634_abnormal_glial_cell1.52479684
44MP0003635_abnormal_synaptic_transmissio1.51434346
45MP0000462_abnormal_digestive_system1.51163781
46MP0004134_abnormal_chest_morphology1.50233699
47MP0002269_muscular_atrophy1.49544729
48MP0005645_abnormal_hypothalamus_physiol1.49015598
49MP0000026_abnormal_inner_ear1.48889806
50MP0004087_abnormal_muscle_fiber1.47969442
51MP0000762_abnormal_tongue_morphology1.46956462
52MP0003221_abnormal_cardiomyocyte_apopto1.46473321
53MP0002067_abnormal_sensory_capabilities1.46213148
54MP0003646_muscle_fatigue1.45156016
55MP0002572_abnormal_emotion/affect_behav1.44636601
56MP0002234_abnormal_pharynx_morphology1.43919492
57MP0004036_abnormal_muscle_relaxation1.42751594
58MP0008058_abnormal_DNA_repair1.42349434
59MP0003111_abnormal_nucleus_morphology1.42334335
60MP0005423_abnormal_somatic_nervous1.42135968
61MP0000749_muscle_degeneration1.42004972
62MP0001501_abnormal_sleep_pattern1.38547096
63MP0001299_abnormal_eye_distance/1.38111867
64MP0005451_abnormal_body_composition1.37733037
65MP0002734_abnormal_mechanical_nocicepti1.37705017
66MP0004185_abnormal_adipocyte_glucose1.35467664
67MP0001849_ear_inflammation1.30695681
68MP0002229_neurodegeneration1.30100049
69MP0003567_abnormal_fetal_cardiomyocyte1.29681542
70MP0003787_abnormal_imprinting1.29340641
71MP0002106_abnormal_muscle_physiology1.28597252
72MP0002752_abnormal_somatic_nervous1.28350459
73MP0004145_abnormal_muscle_electrophysio1.28138052
74MP0003385_abnormal_body_wall1.27496484
75MP0010234_abnormal_vibrissa_follicle1.27091989
76MP0004197_abnormal_fetal_growth/weight/1.27075239
77MP0000759_abnormal_skeletal_muscle1.26193065
78MP0006292_abnormal_olfactory_placode1.25810435
79MP0010630_abnormal_cardiac_muscle1.25313090
80MP0001661_extended_life_span1.19841949
81MP0003122_maternal_imprinting1.19728674
82MP0009379_abnormal_foot_pigmentation1.19331054
83MP0003077_abnormal_cell_cycle1.18801230
84MP0002063_abnormal_learning/memory/cond1.17376659
85MP0001730_embryonic_growth_arrest1.16930410
86MP0004147_increased_porphyrin_level1.16111886
87MP0002882_abnormal_neuron_morphology1.16083531
88MP0010352_gastrointestinal_tract_polyps1.13802647
89MP0002249_abnormal_larynx_morphology1.13453834
90MP0002084_abnormal_developmental_patter1.12616387
91MP0003937_abnormal_limbs/digits/tail_de1.12209043
92MP0009672_abnormal_birth_weight1.11373124
93MP0001968_abnormal_touch/_nociception1.11268660
94MP0005410_abnormal_fertilization1.10209944
95MP0002277_abnormal_respiratory_mucosa1.08764474
96MP0004130_abnormal_muscle_cell1.08340794
97MP0003195_calcinosis1.08328218
98MP0005369_muscle_phenotype1.07987322
99MP0004811_abnormal_neuron_physiology1.07907245
100MP0005666_abnormal_adipose_tissue1.07765318
101MP0004957_abnormal_blastocyst_morpholog1.07509682
102MP0004133_heterotaxia1.07450939
103MP0000537_abnormal_urethra_morphology1.06443385
104MP0009703_decreased_birth_body1.05952952
105MP0002557_abnormal_social/conspecific_i1.05424557
106MP0003984_embryonic_growth_retardation1.05103999
107MP0003861_abnormal_nervous_system1.04689717
108MP0006072_abnormal_retinal_apoptosis1.04674699
109MP0000733_abnormal_muscle_development1.04018775
110MP0005394_taste/olfaction_phenotype1.03860148
111MP0005499_abnormal_olfactory_system1.03860148
112MP0001970_abnormal_pain_threshold1.03810522
113MP0003632_abnormal_nervous_system1.03460912
114MP0003890_abnormal_embryonic-extraembry1.03056218
115MP0003693_abnormal_embryo_hatching1.02859658
116MP0003115_abnormal_respiratory_system1.02547358
117MP0005380_embryogenesis_phenotype1.01335953
118MP0001672_abnormal_embryogenesis/_devel1.01335953
119MP0002088_abnormal_embryonic_growth/wei1.01251223
120MP0002735_abnormal_chemical_nociception1.00819925
121MP0005379_endocrine/exocrine_gland_phen1.00277240
122MP0009697_abnormal_copulation0.99130725
123MP0000955_abnormal_spinal_cord0.98810202
124MP0005195_abnormal_posterior_eye0.98384443
125MP0003329_amyloid_beta_deposits0.97592682
126MP0009250_abnormal_appendicular_skeleto0.97053240
127MP0005253_abnormal_eye_physiology0.96674024
128MP0002066_abnormal_motor_capabilities/c0.96617782
129MP0005646_abnormal_pituitary_gland0.96455493
130MP0000631_abnormal_neuroendocrine_gland0.95878426
131MP0000579_abnormal_nail_morphology0.94962722
132MP0002697_abnormal_eye_size0.94607565
133MP0000049_abnormal_middle_ear0.94604405
134MP0008932_abnormal_embryonic_tissue0.93276426
135MP0000428_abnormal_craniofacial_morphol0.93274978
136MP0005623_abnormal_meninges_morphology0.90427908
137MP0004215_abnormal_myocardial_fiber0.90425816
138MP0000647_abnormal_sebaceous_gland0.90122143
139MP0008007_abnormal_cellular_replicative0.89437100
140MP0003631_nervous_system_phenotype0.89177604
141MP0000569_abnormal_digit_pigmentation0.88637744
142MP0002184_abnormal_innervation0.88608410
143MP0001502_abnormal_circadian_rhythm0.87654891
144MP0008569_lethality_at_weaning0.87385117
145MP0005670_abnormal_white_adipose0.87278434
146MP0000350_abnormal_cell_proliferation0.85805890
147MP0004484_altered_response_of0.84806345
148MP0003705_abnormal_hypodermis_morpholog0.84724623
149MP0003123_paternal_imprinting0.83266286
150MP0004924_abnormal_behavior0.82932545
151MP0005386_behavior/neurological_phenoty0.82932545
152MP0004043_abnormal_pH_regulation0.82858780
153MP0005330_cardiomyopathy0.82306224
154MP0002751_abnormal_autonomic_nervous0.81786849
155MP0001697_abnormal_embryo_size0.81504758
156MP0001727_abnormal_embryo_implantation0.81211531
157MP0008789_abnormal_olfactory_epithelium0.81163824
158MP0005367_renal/urinary_system_phenotyp0.80673201
159MP0000516_abnormal_urinary_system0.80673201
160MP0002081_perinatal_lethality0.80347764
161MP0002736_abnormal_nociception_after0.80310844
162MP0002152_abnormal_brain_morphology0.80310772
163MP0000467_abnormal_esophagus_morphology0.79877396
164MP0002085_abnormal_embryonic_tissue0.79832219
165MP0002233_abnormal_nose_morphology0.79723305
166MP0003633_abnormal_nervous_system0.79655214
167MP0001286_abnormal_eye_development0.78659790
168MP0002295_abnormal_pulmonary_circulatio0.75775780
169MP0001664_abnormal_digestion0.74977878
170MP0002098_abnormal_vibrissa_morphology0.68503606
171MP0001177_atelectasis0.68449275
172MP0001851_eye_inflammation0.67635137
173MP0000613_abnormal_salivary_gland0.67345505
174MP0006276_abnormal_autonomic_nervous0.66291897
175MP0000427_abnormal_hair_cycle0.66253260
176MP0001340_abnormal_eyelid_morphology0.64936218
177MP0000015_abnormal_ear_pigmentation0.64523182

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.49004211
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.49004211
3Neurofibrillary tangles (HP:0002185)4.56378016
4Sensory axonal neuropathy (HP:0003390)3.98911769
5Abnormality of the corticospinal tract (HP:0002492)3.81895574
6Parakeratosis (HP:0001036)3.80331560
7Exercise-induced muscle cramps (HP:0003710)3.72792610
8Exercise-induced myalgia (HP:0003738)3.44658673
9Alacrima (HP:0000522)3.38277776
10Peripheral hypomyelination (HP:0007182)3.32117845
11Onion bulb formation (HP:0003383)3.22612117
12Septo-optic dysplasia (HP:0100842)3.22585169
13Muscle fiber inclusion bodies (HP:0100299)3.07106004
14Cerebral inclusion bodies (HP:0100314)3.06076335
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.04427854
16Duplicated collecting system (HP:0000081)2.99521317
17Nemaline bodies (HP:0003798)2.94532025
18Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.94137505
19White forelock (HP:0002211)2.89939650
20Decreased lacrimation (HP:0000633)2.85274709
21Dynein arm defect of respiratory motile cilia (HP:0012255)2.85087940
22Absent/shortened dynein arms (HP:0200106)2.85087940
23Hypophosphatemic rickets (HP:0004912)2.83395154
24Upper limb muscle weakness (HP:0003484)2.77294166
25Absent septum pellucidum (HP:0001331)2.75295183
26Patchy hypopigmentation of hair (HP:0011365)2.74719587
27Abnormality of the axillary hair (HP:0100134)2.71041003
28Abnormality of secondary sexual hair (HP:0009888)2.71041003
29Abnormality of the left ventricular outflow tract (HP:0011103)2.68709580
30Subaortic stenosis (HP:0001682)2.68709580
31Drooling (HP:0002307)2.68436423
32Abnormality of the renal collecting system (HP:0004742)2.61277251
33Ependymoma (HP:0002888)2.60127850
34Rimmed vacuoles (HP:0003805)2.57236968
35Conical tooth (HP:0000698)2.56704015
36Asplenia (HP:0001746)2.54387255
37Astrocytoma (HP:0009592)2.53502438
38Abnormality of the astrocytes (HP:0100707)2.53502438
39Abnormal auditory evoked potentials (HP:0006958)2.51739990
40Hepatoblastoma (HP:0002884)2.51564947
41Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.48321479
42Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.45575675
43Dysmetric saccades (HP:0000641)2.44590749
44Partial agenesis of the corpus callosum (HP:0001338)2.43053885
45Retinal dysplasia (HP:0007973)2.40536825
46Abnormal ciliary motility (HP:0012262)2.38861259
47Anomalous pulmonary venous return (HP:0010772)2.38820017
48Abnormality of the pulmonary veins (HP:0011718)2.37491427
49Abnormality of the phalanges of the 2nd finger (HP:0009541)2.37058900
50Excessive salivation (HP:0003781)2.35884650
51Thickened helices (HP:0000391)2.35505695
52Focal motor seizures (HP:0011153)2.35366399
53Aplasia/Hypoplasia of the spleen (HP:0010451)2.34279298
54Aplasia involving bones of the extremities (HP:0009825)2.33032852
55Aplasia involving bones of the upper limbs (HP:0009823)2.33032852
56Aplasia of the phalanges of the hand (HP:0009802)2.33032852
57Cupped ear (HP:0000378)2.32272284
58Split foot (HP:0001839)2.29588463
59Cerebral hypomyelination (HP:0006808)2.29364821
60Aplasia cutis congenita (HP:0001057)2.28335372
61High anterior hairline (HP:0009890)2.27178725
62Calcaneovalgus deformity (HP:0001848)2.25587507
63Duplication of thumb phalanx (HP:0009942)2.24765013
64Spastic gait (HP:0002064)2.24550316
65Congenital sensorineural hearing impairment (HP:0008527)2.23686474
66Hypoplastic pelvis (HP:0008839)2.22886796
67Abnormality of the septum pellucidum (HP:0007375)2.20391149
68Poor eye contact (HP:0000817)2.19167234
69Scanning speech (HP:0002168)2.16182787
70Dysmetria (HP:0001310)2.15541244
71Metabolic alkalosis (HP:0200114)2.15433945
72Medulloblastoma (HP:0002885)2.15170433
73Abnormality of the parathyroid morphology (HP:0011766)2.12976312
74Humeroradial synostosis (HP:0003041)2.12968574
75Synostosis involving the elbow (HP:0003938)2.12968574
76Myoglobinuria (HP:0002913)2.10132400
77Urinary urgency (HP:0000012)2.09922688
78Heterotopia (HP:0002282)2.09819385
79Hypoplasia of the iris (HP:0007676)2.09041439
80Abnormality of incisor morphology (HP:0011063)2.07772608
81Osteomalacia (HP:0002749)2.07273965
82Clumsiness (HP:0002312)2.07249233
83Glioma (HP:0009733)2.06870468
84Type 1 muscle fiber predominance (HP:0003803)2.05359942
85Partial duplication of thumb phalanx (HP:0009944)2.03885438
86Decreased central vision (HP:0007663)2.03547267
87Leukodystrophy (HP:0002415)2.02980810
88Abnormal social behavior (HP:0012433)2.02860710
89Impaired social interactions (HP:0000735)2.02860710
90Lower limb muscle weakness (HP:0007340)2.02750057
91Congenital ichthyosiform erythroderma (HP:0007431)2.01875480
92Slow saccadic eye movements (HP:0000514)2.01787628
93Abnormality of the lower motor neuron (HP:0002366)2.01078614
94Supranuclear gaze palsy (HP:0000605)2.00848086
95Muscle hypertrophy of the lower extremities (HP:0008968)1.98778248
96Impaired vibration sensation in the lower limbs (HP:0002166)1.98653935
97Renal agenesis (HP:0000104)1.98580454
98Intention tremor (HP:0002080)1.97232696
99EMG: neuropathic changes (HP:0003445)1.97044757
100Morphological abnormality of the inner ear (HP:0011390)1.96328802
101Abnormality of the middle phalanges of the toes (HP:0010183)1.95328162
102Hypomagnesemia (HP:0002917)1.94095376
103Optic nerve hypoplasia (HP:0000609)1.93791220
104Methylmalonic acidemia (HP:0002912)1.93778500
105Hyperventilation (HP:0002883)1.93362762
106Abnormality of the calcaneus (HP:0008364)1.92391648
107Genital tract atresia (HP:0001827)1.92115105
108Calf muscle hypertrophy (HP:0008981)1.91848553
109Vaginal atresia (HP:0000148)1.91637168
110Overfolded helix (HP:0000396)1.90371927
111Dysdiadochokinesis (HP:0002075)1.90226917
112Esophageal atresia (HP:0002032)1.89906346
113Long nose (HP:0003189)1.89305587
114Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.88329750
115Papillary thyroid carcinoma (HP:0002895)1.88192068
116Shoulder girdle muscle weakness (HP:0003547)1.88160972
117Mixed hearing impairment (HP:0000410)1.87550738
118Deformed tarsal bones (HP:0008119)1.87356409
119Progressive inability to walk (HP:0002505)1.87117659
120Distal arthrogryposis (HP:0005684)1.85913796
121Vertebral arch anomaly (HP:0008438)1.85794663
122Difficulty running (HP:0009046)1.85168916
123Termporal pattern (HP:0011008)1.84742227
124Insidious onset (HP:0003587)1.84742227
125Abnormal respiratory motile cilium physiology (HP:0012261)1.82533911
126Long clavicles (HP:0000890)1.82205402
127Cortical dysplasia (HP:0002539)1.80428526
128Nasolacrimal duct obstruction (HP:0000579)1.79946495
129Limb-girdle muscle weakness (HP:0003325)1.79341659
130Abnormality of the calf musculature (HP:0001430)1.79266340
131Coronal craniosynostosis (HP:0004440)1.78293295
132Abnormality of molar morphology (HP:0011070)1.77173524
133Abnormality of molar (HP:0011077)1.77173524
134Bifid scrotum (HP:0000048)1.76840862
135Submucous cleft hard palate (HP:0000176)1.76177167
136Tubulointerstitial nephritis (HP:0001970)1.76083545
137Premature skin wrinkling (HP:0100678)1.75309823
138Erythroderma (HP:0001019)1.74508995
139Abnormal respiratory motile cilium morphology (HP:0005938)1.73974107
140Abnormal respiratory epithelium morphology (HP:0012253)1.73974107
141Urinary bladder sphincter dysfunction (HP:0002839)1.72931152
142Pheochromocytoma (HP:0002666)1.71211322
143Chin dimple (HP:0010751)1.70372020
144Neonatal respiratory distress (HP:0002643)1.70097584
145Increased serum pyruvate (HP:0003542)1.69683727
146Abnormality of glycolysis (HP:0004366)1.69683727
147Abnormal hair whorl (HP:0010721)1.69581674
148Decreased motor nerve conduction velocity (HP:0003431)1.69391816
149Obsessive-compulsive behavior (HP:0000722)1.69050701
150Germ cell neoplasia (HP:0100728)1.69004887
151Myotonia (HP:0002486)1.68950307
152Rhabdomyosarcoma (HP:0002859)1.68065872
153Abnormality of the labia minora (HP:0012880)1.67567628
154Pelvic girdle muscle weakness (HP:0003749)1.65920973
155Truncal ataxia (HP:0002078)1.64846492
156Abnormality of the musculature of the pelvis (HP:0001469)1.64209966
157Abnormality of the hip-girdle musculature (HP:0001445)1.64209966
158Cubitus valgus (HP:0002967)1.62807601
159Central scotoma (HP:0000603)1.62191284
160Bowel incontinence (HP:0002607)1.61347566
161Proximal amyotrophy (HP:0007126)1.58770219
162Amyotrophic lateral sclerosis (HP:0007354)1.57960364
163Ankyloglossia (HP:0010296)1.56965630
164Malignant gastrointestinal tract tumors (HP:0006749)1.56478149
165Gastrointestinal carcinoma (HP:0002672)1.56478149
166Bundle branch block (HP:0011710)1.56098773
167Colon cancer (HP:0003003)1.55398154
168Bell-shaped thorax (HP:0001591)1.54776167
169Protruding tongue (HP:0010808)1.53125314
170Spastic paraplegia (HP:0001258)1.52709712
171Hyporeflexia of lower limbs (HP:0002600)1.52567387
172Centrally nucleated skeletal muscle fibers (HP:0003687)1.51931471
173Tracheomalacia (HP:0002779)1.51703670
174Neonatal hypoglycemia (HP:0001998)1.51259780
175Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.51173854
176Scapular winging (HP:0003691)1.50593661
177Tented upper lip vermilion (HP:0010804)1.50404050
178Aplasia/Hypoplasia of the sternum (HP:0006714)1.49310820
179Cutaneous finger syndactyly (HP:0010554)1.48780890
180Gaze-evoked nystagmus (HP:0000640)1.48601466
181Turricephaly (HP:0000262)1.48352564
182Abnormality of the epiphyses of the hand (HP:0005924)1.48208548
183Cerebellar dysplasia (HP:0007033)1.47501888
184Neuroendocrine neoplasm (HP:0100634)1.47316925
185Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.47180534
186Sandal gap (HP:0001852)1.46010813
187Gastroesophageal reflux (HP:0002020)1.45421240
188Rhabdomyolysis (HP:0003201)1.44976937
189Deep philtrum (HP:0002002)1.44711901
190Renovascular hypertension (HP:0100817)1.43900754

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.56368485
2CASK4.24405363
3OXSR13.50432445
4PKN13.36050043
5EEF2K2.86760772
6BRD42.78275261
7PBK2.50846630
8SCYL22.41997130
9TNIK2.37095478
10EPHA42.32712849
11INSRR2.28576330
12BCR2.13974583
13MAP3K62.09802315
14CDC71.95206637
15STK38L1.93743913
16EPHB11.93669109
17LATS11.93210642
18NEK61.81634193
19ERBB31.78966657
20CAMK1D1.72519731
21PRKD31.69822467
22CSNK1A1L1.64568645
23MAPK151.58445561
24GRK11.57066343
25ICK1.56840523
26MAP2K41.55020531
27TTN1.51820164
28FGFR21.49458565
29PNCK1.47395387
30MUSK1.47121309
31NEK91.46317842
32CAMK2B1.45654109
33MET1.43386095
34CLK11.41747979
35BMPR1B1.41050872
36CDK121.40360267
37PLK41.38521670
38WNK41.30995666
39CSNK1G31.30834850
40PDGFRA1.28948114
41FGR1.28155153
42PRPF4B1.24892233
43WNK11.24078429
44BLK1.23328778
45SRPK11.22572036
46TRPM71.20499033
47ROCK21.19618507
48SGK4941.18516715
49SGK2231.18516715
50UHMK11.17944197
51BRSK21.15783914
52MST41.14896972
53CSNK1G11.14602078
54MAPKAPK51.13118596
55CAMK2D1.13011368
56MAP3K71.12123760
57CDK191.11375152
58IRAK21.09761132
59MKNK21.07522039
60CDK31.05810576
61CDK61.02537940
62PKN21.00768907
63CAMKK20.99957431
64YES10.99536318
65DYRK20.98768007
66MAPK130.97992115
67GRK70.97720980
68PRKCE0.97178689
69RET0.96888031
70CAMK2A0.95464311
71MARK20.93962304
72CAMKK10.93235866
73MARK10.93233236
74LATS20.93104028
75CSNK1G20.92580689
76TRIB30.91611815
77CAMK2G0.91318091
78NTRK30.87523870
79ATM0.84595597
80PRKCQ0.83762764
81SGK20.83493432
82ADRBK20.83162869
83STK160.82464958
84NTRK20.81046831
85PASK0.80894478
86PRKAA10.77683188
87BMPR20.77136040
88PHKG10.76988854
89PHKG20.76988854
90IRAK10.76526343
91TTK0.76017764
92PIK3CG0.75921368
93EIF2AK30.75686432
94MTOR0.74783443
95ATR0.73547373
96MKNK10.73422249
97NTRK10.72389559
98MAPK100.72322235
99EIF2AK20.72205992
100ERBB40.71308515
101TRIM280.69747307
102LIMK10.69566548
103CDK50.66468871
104PRKDC0.66288813
105MAP3K130.65633265
106MAP3K140.65518898
107PLK20.64677822
108MAP2K70.64575199
109IRAK40.63260269
110CAMK40.63059572
111CHEK10.62502806
112PRKG10.62150726
113CDK20.61436381
114TNK20.61294580
115MINK10.61075671
116STK380.60776852
117SGK30.60484083
118MAP3K100.59284680
119MAPK70.59074070
120GSK3A0.57379972
121AKT30.57191102
122DYRK1A0.56431755
123CDK10.56416319
124IRAK30.56243356
125PAK30.55902112
126AKT20.55882219
127RPS6KA40.54941285
128RPS6KB20.54470292
129NUAK10.54437809
130GSK3B0.54142078
131PAK60.54015083
132SIK20.53824217
133RPS6KB10.53801309
134CSNK1E0.53275222
135STK110.53113505
136FES0.52886004
137KSR10.52131955
138FER0.52098645
139PLK10.49830534
140SGK10.48245394
141FGFR10.47446089
142PRKD10.47022690
143RPS6KA30.46712659
144CAMK1G0.46394753
145CAMK10.46238868
146PRKACA0.44705688
147CSNK1D0.43876916
148CSNK1A10.43781221
149FYN0.43154996
150CDK140.40569908
151CDK150.39514575
152MST1R0.39416075
153OBSCN0.39118095
154MAP2K20.37168439
155CDK180.36065789
156RPS6KA50.35551423
157MAP3K40.34212507
158PRKD20.33117165
159CDK11A0.32320700

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.04197484
2Fatty acid elongation_Homo sapiens_hsa000623.45255960
3Steroid biosynthesis_Homo sapiens_hsa001003.34112966
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.67023804
5Ether lipid metabolism_Homo sapiens_hsa005652.60699262
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.53824404
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.48945294
8Lysine degradation_Homo sapiens_hsa003101.98780625
9Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.89336781
10DNA replication_Homo sapiens_hsa030301.86357603
11Phototransduction_Homo sapiens_hsa047441.85152815
12Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.85147212
13Axon guidance_Homo sapiens_hsa043601.84527062
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.82631662
15Nicotine addiction_Homo sapiens_hsa050331.76239842
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.75406560
17Histidine metabolism_Homo sapiens_hsa003401.71805364
18mRNA surveillance pathway_Homo sapiens_hsa030151.71479665
19Sphingolipid metabolism_Homo sapiens_hsa006001.68767513
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.68123930
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67097158
22Glutamatergic synapse_Homo sapiens_hsa047241.64321219
23Propanoate metabolism_Homo sapiens_hsa006401.63211080
24Serotonergic synapse_Homo sapiens_hsa047261.61896668
25Linoleic acid metabolism_Homo sapiens_hsa005911.52549040
26Oxidative phosphorylation_Homo sapiens_hsa001901.50118254
27Morphine addiction_Homo sapiens_hsa050321.48108817
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45212877
29Protein export_Homo sapiens_hsa030601.40041370
30GABAergic synapse_Homo sapiens_hsa047271.39697455
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.38350044
32RNA transport_Homo sapiens_hsa030131.37241091
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34331057
34Biosynthesis of amino acids_Homo sapiens_hsa012301.33211304
35Vitamin B6 metabolism_Homo sapiens_hsa007501.32597207
36Arachidonic acid metabolism_Homo sapiens_hsa005901.27279112
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27008289
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.25642319
39Carbon metabolism_Homo sapiens_hsa012001.25514858
40Cell cycle_Homo sapiens_hsa041101.24656737
41Adherens junction_Homo sapiens_hsa045201.24200727
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.22840540
43Taste transduction_Homo sapiens_hsa047421.21051781
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.19697805
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17805944
46Pyruvate metabolism_Homo sapiens_hsa006201.17705776
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17445549
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15280887
49Salivary secretion_Homo sapiens_hsa049701.13496531
50Inositol phosphate metabolism_Homo sapiens_hsa005621.12378603
51Longevity regulating pathway - mammal_Homo sapiens_hsa042111.12194116
52Arginine and proline metabolism_Homo sapiens_hsa003301.10796053
53Central carbon metabolism in cancer_Homo sapiens_hsa052301.10645606
54Oocyte meiosis_Homo sapiens_hsa041141.09969574
55Collecting duct acid secretion_Homo sapiens_hsa049661.09879426
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08390812
57* Fanconi anemia pathway_Homo sapiens_hsa034601.08378101
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07774420
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07493240
60Circadian rhythm_Homo sapiens_hsa047101.05426438
61Choline metabolism in cancer_Homo sapiens_hsa052311.05224937
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03743941
63Alzheimers disease_Homo sapiens_hsa050101.03658548
64AMPK signaling pathway_Homo sapiens_hsa041521.03474865
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02057516
66Ovarian steroidogenesis_Homo sapiens_hsa049131.01159357
67Cocaine addiction_Homo sapiens_hsa050301.01124960
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00865732
69Endometrial cancer_Homo sapiens_hsa052130.99337836
70Rheumatoid arthritis_Homo sapiens_hsa053230.98610697
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.98008973
72Autoimmune thyroid disease_Homo sapiens_hsa053200.97712482
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95755783
74mTOR signaling pathway_Homo sapiens_hsa041500.95119703
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94708498
76Butanoate metabolism_Homo sapiens_hsa006500.93574421
77RNA degradation_Homo sapiens_hsa030180.92545129
78Colorectal cancer_Homo sapiens_hsa052100.91229162
79Glioma_Homo sapiens_hsa052140.91079878
80Insulin signaling pathway_Homo sapiens_hsa049100.90374686
81Hippo signaling pathway_Homo sapiens_hsa043900.89599022
82Long-term potentiation_Homo sapiens_hsa047200.89500734
83Sulfur metabolism_Homo sapiens_hsa009200.89440392
84Retinol metabolism_Homo sapiens_hsa008300.89062900
85Glucagon signaling pathway_Homo sapiens_hsa049220.87952694
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87744588
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.86518112
88MicroRNAs in cancer_Homo sapiens_hsa052060.86225565
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85687919
90Mismatch repair_Homo sapiens_hsa034300.85658087
91Nucleotide excision repair_Homo sapiens_hsa034200.84341198
92ABC transporters_Homo sapiens_hsa020100.84251345
93Base excision repair_Homo sapiens_hsa034100.82985426
94Circadian entrainment_Homo sapiens_hsa047130.82631969
95Ras signaling pathway_Homo sapiens_hsa040140.81599469
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81116067
97Long-term depression_Homo sapiens_hsa047300.80302399
98ErbB signaling pathway_Homo sapiens_hsa040120.78826576
99Oxytocin signaling pathway_Homo sapiens_hsa049210.77700030
100Arginine biosynthesis_Homo sapiens_hsa002200.77617312
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77327894
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76942490
103Vitamin digestion and absorption_Homo sapiens_hsa049770.76832485
104Renin secretion_Homo sapiens_hsa049240.76588300
105Chronic myeloid leukemia_Homo sapiens_hsa052200.76154774
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75610468
107Spliceosome_Homo sapiens_hsa030400.75342221
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73826232
109Calcium signaling pathway_Homo sapiens_hsa040200.71447559
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71422590
111Pancreatic secretion_Homo sapiens_hsa049720.70074381
112Fatty acid biosynthesis_Homo sapiens_hsa000610.68957719
113Tyrosine metabolism_Homo sapiens_hsa003500.68251561
114One carbon pool by folate_Homo sapiens_hsa006700.68065479
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67972627
116Basal transcription factors_Homo sapiens_hsa030220.66808152
117Gastric acid secretion_Homo sapiens_hsa049710.66208563
118Cardiac muscle contraction_Homo sapiens_hsa042600.65431564
119Estrogen signaling pathway_Homo sapiens_hsa049150.64882154
120Amphetamine addiction_Homo sapiens_hsa050310.64565302
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64317063
122Phagosome_Homo sapiens_hsa041450.62798226
123Malaria_Homo sapiens_hsa051440.62738533
124Vibrio cholerae infection_Homo sapiens_hsa051100.62674374
125Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62663605
126Mineral absorption_Homo sapiens_hsa049780.62533683
127Hedgehog signaling pathway_Homo sapiens_hsa043400.62009062
128Non-small cell lung cancer_Homo sapiens_hsa052230.61991774
129Prostate cancer_Homo sapiens_hsa052150.61230089
130Pentose phosphate pathway_Homo sapiens_hsa000300.59943321
131Type II diabetes mellitus_Homo sapiens_hsa049300.59409602
132Parkinsons disease_Homo sapiens_hsa050120.58866822
133Thyroid cancer_Homo sapiens_hsa052160.58854678
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58563557
135Cholinergic synapse_Homo sapiens_hsa047250.57884245
136Insulin secretion_Homo sapiens_hsa049110.57508987
137Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57275397
138cAMP signaling pathway_Homo sapiens_hsa040240.57144279
139ECM-receptor interaction_Homo sapiens_hsa045120.56999342
140Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56489378
141Basal cell carcinoma_Homo sapiens_hsa052170.56346945
142Renal cell carcinoma_Homo sapiens_hsa052110.56053551
143Wnt signaling pathway_Homo sapiens_hsa043100.53520200
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53205318
145Graft-versus-host disease_Homo sapiens_hsa053320.52320519
146Maturity onset diabetes of the young_Homo sapiens_hsa049500.52296680
147Chemical carcinogenesis_Homo sapiens_hsa052040.51615452
148Dopaminergic synapse_Homo sapiens_hsa047280.48068913
149Complement and coagulation cascades_Homo sapiens_hsa046100.46898254
150African trypanosomiasis_Homo sapiens_hsa051430.46542412
151Non-homologous end-joining_Homo sapiens_hsa034500.46401131
152Peroxisome_Homo sapiens_hsa041460.46119302
153Staphylococcus aureus infection_Homo sapiens_hsa051500.45892496
154Melanogenesis_Homo sapiens_hsa049160.43322096
155Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42838503
156Huntingtons disease_Homo sapiens_hsa050160.40624953
157Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39822709
158beta-Alanine metabolism_Homo sapiens_hsa004100.39679259
159Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38965785
160Tight junction_Homo sapiens_hsa045300.38548502
161Glycerophospholipid metabolism_Homo sapiens_hsa005640.38435755
162Phospholipase D signaling pathway_Homo sapiens_hsa040720.37158780
163Dilated cardiomyopathy_Homo sapiens_hsa054140.37084490
164Asthma_Homo sapiens_hsa053100.36940996
165Fatty acid metabolism_Homo sapiens_hsa012120.35918600
166Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35621233
167Glycosaminoglycan degradation_Homo sapiens_hsa005310.35407075

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