FANCB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Fanconi anemia complementation group B. This protein is assembled into a nucleoprotein complex that is involved in the repair of DNA lesions. Mutations in this gene can cause chromosome instability and VACTERL syndrome with hydrocephalus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.74567345
2DNA unwinding involved in DNA replication (GO:0006268)5.28992199
3DNA strand elongation involved in DNA replication (GO:0006271)5.19944517
4DNA replication initiation (GO:0006270)5.15845517
5mitotic chromosome condensation (GO:0007076)5.07708449
6telomere maintenance via semi-conservative replication (GO:0032201)4.94612404
7DNA strand elongation (GO:0022616)4.93395006
8protein localization to chromosome, centromeric region (GO:0071459)4.81457733
9mitotic metaphase plate congression (GO:0007080)4.73458216
10nuclear pore organization (GO:0006999)4.69347802
11nuclear pore complex assembly (GO:0051292)4.64724077
12mitotic recombination (GO:0006312)4.62411384
13mitotic sister chromatid segregation (GO:0000070)4.61367166
14DNA replication checkpoint (GO:0000076)4.61154207
15kinetochore organization (GO:0051383)4.58273709
16CENP-A containing nucleosome assembly (GO:0034080)4.57102541
17telomere maintenance via recombination (GO:0000722)4.56628427
18attachment of spindle microtubules to kinetochore (GO:0008608)4.55742078
19chromatin remodeling at centromere (GO:0031055)4.50412094
20mitotic nuclear envelope disassembly (GO:0007077)4.46763051
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.46185577
22regulation of sister chromatid cohesion (GO:0007063)4.46004053
23sister chromatid segregation (GO:0000819)4.45725890
24replication fork processing (GO:0031297)4.42664099
25metaphase plate congression (GO:0051310)4.24034771
26DNA double-strand break processing (GO:0000729)4.23096362
27negative regulation of DNA-dependent DNA replication (GO:2000104)4.19737602
28nuclear envelope disassembly (GO:0051081)4.16751485
29membrane disassembly (GO:0030397)4.16751485
30DNA ligation (GO:0006266)4.16317868
31regulation of DNA endoreduplication (GO:0032875)4.11867832
32DNA replication-independent nucleosome organization (GO:0034724)4.09487505
33DNA replication-independent nucleosome assembly (GO:0006336)4.09487505
34DNA replication-dependent nucleosome assembly (GO:0006335)4.06210639
35DNA replication-dependent nucleosome organization (GO:0034723)4.06210639
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.05754563
37folic acid-containing compound biosynthetic process (GO:0009396)4.04892202
38nucleotide-excision repair, DNA gap filling (GO:0006297)4.04181050
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.96757538
40telomere maintenance via telomere lengthening (GO:0010833)3.96534107
41establishment of chromosome localization (GO:0051303)3.93075510
42non-recombinational repair (GO:0000726)3.90680032
43double-strand break repair via nonhomologous end joining (GO:0006303)3.90680032
44mitotic sister chromatid cohesion (GO:0007064)3.86952251
45proteasome assembly (GO:0043248)3.86148707
46spindle checkpoint (GO:0031577)3.84667293
47meiotic chromosome segregation (GO:0045132)3.82860407
48nucleobase biosynthetic process (GO:0046112)3.80855959
49histone exchange (GO:0043486)3.79280250
50regulation of chromosome segregation (GO:0051983)3.77061245
51establishment of integrated proviral latency (GO:0075713)3.76642985
52regulation of spindle organization (GO:0090224)3.74221174
53negative regulation of mitotic sister chromatid separation (GO:2000816)3.69722257
54negative regulation of mitotic sister chromatid segregation (GO:0033048)3.69722257
55negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.69722257
56negative regulation of sister chromatid segregation (GO:0033046)3.69722257
57negative regulation of chromosome segregation (GO:0051985)3.69037961
58translesion synthesis (GO:0019985)3.67338859
59kinetochore assembly (GO:0051382)3.66848562
60spindle assembly checkpoint (GO:0071173)3.63653969
61negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.62696941
62chromosome segregation (GO:0007059)3.60872628
63protein localization to chromosome (GO:0034502)3.59883831
64DNA duplex unwinding (GO:0032508)3.59171743
65purine nucleobase biosynthetic process (GO:0009113)3.58929837
66DNA geometric change (GO:0032392)3.58414842
67pore complex assembly (GO:0046931)3.58116912
68IMP biosynthetic process (GO:0006188)3.58109507
69formation of translation preinitiation complex (GO:0001731)3.56801160
70regulation of mitotic metaphase/anaphase transition (GO:0030071)3.56068347
71somatic diversification of immune receptors via somatic mutation (GO:0002566)3.54856478
72somatic hypermutation of immunoglobulin genes (GO:0016446)3.54856478
73mitotic spindle assembly checkpoint (GO:0007094)3.54809335
74postreplication repair (GO:0006301)3.53833948
75negative regulation of DNA recombination (GO:0045910)3.53323286
76centriole replication (GO:0007099)3.52797008
77regulation of centrosome cycle (GO:0046605)3.52792283
78mitotic spindle checkpoint (GO:0071174)3.52252754
79regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.50950009
80chromosome condensation (GO:0030261)3.49944167
81ribosome assembly (GO:0042255)3.48691326
82chromatin assembly or disassembly (GO:0006333)3.48399976
83regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.46833738
84regulation of mitotic spindle checkpoint (GO:1903504)3.46833738
85positive regulation of chromosome segregation (GO:0051984)3.46731330
86resolution of meiotic recombination intermediates (GO:0000712)3.43879999
87histone-serine phosphorylation (GO:0035404)3.43514517
88DNA catabolic process, exonucleolytic (GO:0000738)3.41276089
89regulation of double-strand break repair via homologous recombination (GO:0010569)3.41137348
90regulation of sister chromatid segregation (GO:0033045)3.39141550
91regulation of mitotic sister chromatid separation (GO:0010965)3.39141550
92regulation of mitotic sister chromatid segregation (GO:0033047)3.39141550
93mitotic G2 DNA damage checkpoint (GO:0007095)3.38944426
94synapsis (GO:0007129)3.36940085
95telomere maintenance (GO:0000723)3.30960263
96maturation of SSU-rRNA (GO:0030490)3.29651784
97telomere organization (GO:0032200)3.29119361
98regulation of helicase activity (GO:0051095)3.27871382
99anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.27562145
100IMP metabolic process (GO:0046040)3.26368437
101nuclear envelope organization (GO:0006998)3.25029802
102protein K6-linked ubiquitination (GO:0085020)3.24971674
103microtubule depolymerization (GO:0007019)3.23600659
104DNA conformation change (GO:0071103)3.23078666
105recombinational repair (GO:0000725)3.21830323
106double-strand break repair via homologous recombination (GO:0000724)3.21382140
107DNA topological change (GO:0006265)3.20861845
108regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.20332346
109mitotic cell cycle (GO:0000278)3.14263306
110mismatch repair (GO:0006298)3.13308530
111regulation of mitotic spindle organization (GO:0060236)3.12676551
112mitotic G2/M transition checkpoint (GO:0044818)3.12420923
113DNA packaging (GO:0006323)3.11901742
114maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.11040299
115cell cycle G1/S phase transition (GO:0044843)3.00826753
116G1/S transition of mitotic cell cycle (GO:0000082)3.00826753
117positive regulation of mitotic sister chromatid separation (GO:1901970)3.00703609
118positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.00703609
119positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.00703609
120ATP-dependent chromatin remodeling (GO:0043044)3.00107176
121negative regulation of mitosis (GO:0045839)2.99120277
122regulation of centriole replication (GO:0046599)2.98562119
123mitotic DNA integrity checkpoint (GO:0044774)2.97846226

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.59098216
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.49428799
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.98291382
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.77430387
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26935332
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.95367119
7AR_21909140_ChIP-Seq_LNCAP_Human2.92366411
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.71233623
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67189463
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.66178614
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.54889125
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51180134
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45443141
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.43764200
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.35418735
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.28426306
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24341895
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.17054159
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12976555
20XRN2_22483619_ChIP-Seq_HELA_Human2.11415919
21* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09047431
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06685959
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06495081
24VDR_23849224_ChIP-Seq_CD4+_Human2.00737517
25E2F7_22180533_ChIP-Seq_HELA_Human11.1035622
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99241594
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88632249
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.85268695
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84027654
30DCP1A_22483619_ChIP-Seq_HELA_Human1.82217058
31FOXP3_21729870_ChIP-Seq_TREG_Human1.80347529
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78651081
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78455649
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77038938
35ELK1_19687146_ChIP-ChIP_HELA_Human1.74349065
36TTF2_22483619_ChIP-Seq_HELA_Human1.71652994
37EWS_26573619_Chip-Seq_HEK293_Human1.68808975
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68330073
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66678624
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63896495
41GABP_19822575_ChIP-Seq_HepG2_Human1.61508024
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53271452
43* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53021027
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52802270
45* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52320290
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51277428
47MYC_22102868_ChIP-Seq_BL_Human1.48302329
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46950313
49KDM5A_27292631_Chip-Seq_BREAST_Human1.45889492
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.45778527
51FUS_26573619_Chip-Seq_HEK293_Human1.43201974
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42733689
53CIITA_25753668_ChIP-Seq_RAJI_Human1.38020573
54* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37374445
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34559633
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29913021
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29641303
58E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28779736
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27209725
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26139247
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21410957
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19851104
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19513348
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16979545
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15165588
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14793756
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14290586
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12212391
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.11230112
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.10341594
71TFEB_21752829_ChIP-Seq_HELA_Human1.09976876
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09965822
73ZNF274_21170338_ChIP-Seq_K562_Hela1.09214426
74SOX2_16153702_ChIP-ChIP_HESCs_Human1.05648020
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04913681
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04844534
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02399126
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01904745
79CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00960086
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00509633
81ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99920628
82SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99559254
83VDR_22108803_ChIP-Seq_LS180_Human0.98555970
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98150631
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97792009
86YY1_21170310_ChIP-Seq_MESCs_Mouse0.95915167
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95914372
88MYC_18940864_ChIP-ChIP_HL60_Human0.95762309
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94334858
90IRF1_19129219_ChIP-ChIP_H3396_Human0.94216652
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93265981
92HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92797733
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92147271
94FLI1_27457419_Chip-Seq_LIVER_Mouse0.90800166
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89147769
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88592467
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87907756
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86869040
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86615535
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86264841
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85362782
102IGF1R_20145208_ChIP-Seq_DFB_Human0.85236269
103ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84722932
104NOTCH1_21737748_ChIP-Seq_TLL_Human0.84333463
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81472849
106BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81283366
107TAF15_26573619_Chip-Seq_HEK293_Human0.79366215
108VDR_21846776_ChIP-Seq_THP-1_Human0.79350248
109NANOG_21062744_ChIP-ChIP_HESCs_Human0.79337638
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.75906813
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75862623
112P300_19829295_ChIP-Seq_ESCs_Human0.74025058
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.73978814
114SPI1_23547873_ChIP-Seq_NB4_Human0.71459310
115NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.71076525
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.70198404
117NANOG_16153702_ChIP-ChIP_HESCs_Human0.69813919
118SOX17_20123909_ChIP-Seq_XEN_Mouse0.69590409
119CHD1_26751641_Chip-Seq_LNCaP_Human0.68443611
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.68188813
121EZH2_27294783_Chip-Seq_NPCs_Mouse0.66805465
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.65681799
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.63444470
124ZFP57_27257070_Chip-Seq_ESCs_Mouse0.62333784
125SOX9_26525672_Chip-Seq_HEART_Mouse0.60882162
126PCGF2_27294783_Chip-Seq_ESCs_Mouse0.59553382
127NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.59270653

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.33649680
2MP0010094_abnormal_chromosome_stability5.18983428
3MP0003111_abnormal_nucleus_morphology4.70993149
4MP0004957_abnormal_blastocyst_morpholog4.51417361
5MP0003077_abnormal_cell_cycle4.21186334
6MP0008057_abnormal_DNA_replication3.84636025
7MP0008058_abnormal_DNA_repair3.13101977
8MP0008932_abnormal_embryonic_tissue2.90755897
9MP0010352_gastrointestinal_tract_polyps2.68207290
10MP0008007_abnormal_cellular_replicative2.65481534
11MP0006292_abnormal_olfactory_placode2.60249321
12MP0003123_paternal_imprinting2.44927722
13MP0010307_abnormal_tumor_latency2.41425610
14MP0001730_embryonic_growth_arrest2.40723765
15MP0000350_abnormal_cell_proliferation2.32810567
16MP0006054_spinal_hemorrhage2.04502594
17MP0008877_abnormal_DNA_methylation1.90712090
18MP0005380_embryogenesis_phenotype1.90636219
19MP0001672_abnormal_embryogenesis/_devel1.90636219
20MP0003121_genomic_imprinting1.89592527
21MP0002396_abnormal_hematopoietic_system1.88115165
22MP0001697_abnormal_embryo_size1.87572922
23MP0003941_abnormal_skin_development1.84836650
24MP0003984_embryonic_growth_retardation1.77546869
25MP0002088_abnormal_embryonic_growth/wei1.74356289
26MP0003718_maternal_effect1.73631854
27MP0003567_abnormal_fetal_cardiomyocyte1.65005014
28MP0002080_prenatal_lethality1.64908752
29MP0003806_abnormal_nucleotide_metabolis1.61979263
30MP0002085_abnormal_embryonic_tissue1.61893752
31MP0000490_abnormal_crypts_of1.61036427
32MP0005076_abnormal_cell_differentiation1.58237538
33MP0003136_yellow_coat_color1.58088003
34MP0003786_premature_aging1.56493915
35MP0003890_abnormal_embryonic-extraembry1.52123436
36MP0002086_abnormal_extraembryonic_tissu1.51144213
37MP0000372_irregular_coat_pigmentation1.48804498
38MP0004197_abnormal_fetal_growth/weight/1.47768784
39MP0002084_abnormal_developmental_patter1.47120413
40MP0002019_abnormal_tumor_incidence1.42746988
41MP0004808_abnormal_hematopoietic_stem1.40683736
42MP0000313_abnormal_cell_death1.37557974
43MP0010030_abnormal_orbit_morphology1.29218606
44MP0000537_abnormal_urethra_morphology1.22952015
45MP0009697_abnormal_copulation1.19270138
46MP0002102_abnormal_ear_morphology1.18084015
47MP0010234_abnormal_vibrissa_follicle1.15111201
48MP0002233_abnormal_nose_morphology1.13522869
49MP0001529_abnormal_vocalization1.13515236
50MP0003705_abnormal_hypodermis_morpholog1.09768219
51MP0006035_abnormal_mitochondrial_morpho1.06373886
52MP0000703_abnormal_thymus_morphology1.03899543
53MP0009053_abnormal_anal_canal1.01934791
54MP0003937_abnormal_limbs/digits/tail_de1.00496686
55MP0002210_abnormal_sex_determination0.99950095
56MP0001293_anophthalmia0.99317627
57MP0005397_hematopoietic_system_phenotyp0.97305044
58MP0001545_abnormal_hematopoietic_system0.97305044
59MP0004147_increased_porphyrin_level0.95509808
60MP0003119_abnormal_digestive_system0.94107498
61MP0003315_abnormal_perineum_morphology0.93750724
62MP0002234_abnormal_pharynx_morphology0.93235655
63MP0001915_intracranial_hemorrhage0.93035202
64MP0009333_abnormal_splenocyte_physiolog0.92954346
65MP0002398_abnormal_bone_marrow0.91734785
66MP0001145_abnormal_male_reproductive0.90280882
67MP0002722_abnormal_immune_system0.90197907
68MP0008789_abnormal_olfactory_epithelium0.90013201
69MP0005408_hypopigmentation0.89524673
70MP0009672_abnormal_birth_weight0.88760486
71MP0006072_abnormal_retinal_apoptosis0.88276329
72MP0000569_abnormal_digit_pigmentation0.88148766
73MP0008995_early_reproductive_senescence0.86517804
74MP0003186_abnormal_redox_activity0.85376602
75MP0003763_abnormal_thymus_physiology0.85169268
76MP0005384_cellular_phenotype0.84805599
77MP0001119_abnormal_female_reproductive0.84192567
78MP0006036_abnormal_mitochondrial_physio0.83974534
79MP0002095_abnormal_skin_pigmentation0.83889697
80MP0002111_abnormal_tail_morphology0.82347552
81MP0009703_decreased_birth_body0.82329463
82MP0001177_atelectasis0.81782948
83MP0000049_abnormal_middle_ear0.81655873
84MP0005023_abnormal_wound_healing0.81579073
85MP0005395_other_phenotype0.80297381
86MP0000689_abnormal_spleen_morphology0.80086697
87MP0005621_abnormal_cell_physiology0.79892180
88MP0000653_abnormal_sex_gland0.79230562
89MP0002009_preneoplasia0.76569340
90MP0001929_abnormal_gametogenesis0.76487829
91MP0005171_absent_coat_pigmentation0.76167656
92MP0002751_abnormal_autonomic_nervous0.75712467
93MP0000647_abnormal_sebaceous_gland0.74214587
94MP0009278_abnormal_bone_marrow0.73206314
95MP0000427_abnormal_hair_cycle0.72125616
96MP0000358_abnormal_cell_content/0.71623010
97MP0003566_abnormal_cell_adhesion0.71490163
98MP0001849_ear_inflammation0.69965464
99MP0004264_abnormal_extraembryonic_tissu0.69764397
100MP0003115_abnormal_respiratory_system0.68902704
101MP0002429_abnormal_blood_cell0.68867174
102MP0002877_abnormal_melanocyte_morpholog0.68542378
103MP0001324_abnormal_eye_pigmentation0.68346702
104MP0005391_vision/eye_phenotype0.68130076
105MP0000733_abnormal_muscle_development0.68073302
106MP0003861_abnormal_nervous_system0.67984145
107MP0002092_abnormal_eye_morphology0.67456956
108MP0002090_abnormal_vision0.67409234
109MP0002177_abnormal_outer_ear0.66292636
110MP0000428_abnormal_craniofacial_morphol0.66024740
111MP0005367_renal/urinary_system_phenotyp0.63595156
112MP0000516_abnormal_urinary_system0.63595156
113MP0005174_abnormal_tail_pigmentation0.62952066
114MP0003698_abnormal_male_reproductive0.62677881
115MP0003699_abnormal_female_reproductive0.62433649
116MP0001346_abnormal_lacrimal_gland0.62323977
117MP0003950_abnormal_plasma_membrane0.60990369
118MP0002925_abnormal_cardiovascular_devel0.60828526
119MP0003221_abnormal_cardiomyocyte_apopto0.60693289
120MP0000858_altered_metastatic_potential0.60140634
121MP0002160_abnormal_reproductive_system0.59774297
122MP0002282_abnormal_trachea_morphology0.59529642
123MP0002938_white_spotting0.59247473
124MP0001485_abnormal_pinna_reflex0.58247469
125MP0000432_abnormal_head_morphology0.57231117
126MP0004133_heterotaxia0.56839961
127MP0000477_abnormal_intestine_morphology0.56733831
128MP0003755_abnormal_palate_morphology0.56112768
129MP0005389_reproductive_system_phenotype0.56039107
130MP0000465_gastrointestinal_hemorrhage0.54381130
131MP0005075_abnormal_melanosome_morpholog0.53856931
132MP0010678_abnormal_skin_adnexa0.53810001
133MP0003935_abnormal_craniofacial_develop0.53791596
134MP0001286_abnormal_eye_development0.53106020
135MP0000716_abnormal_immune_system0.52815414
136MP0003943_abnormal_hepatobiliary_system0.52565141
137MP0002697_abnormal_eye_size0.49823060

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.98502872
2Chromsome breakage (HP:0040012)4.19241893
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.93924696
4* Abnormality of chromosome stability (HP:0003220)3.81000211
5Breast hypoplasia (HP:0003187)3.69954904
6Volvulus (HP:0002580)3.53623030
7Reticulocytopenia (HP:0001896)3.49436346
8Increased nuchal translucency (HP:0010880)3.40219428
9Selective tooth agenesis (HP:0001592)3.40122786
10Colon cancer (HP:0003003)3.27800976
11* Meckel diverticulum (HP:0002245)3.27082752
12Ependymoma (HP:0002888)3.22029026
13Patellar aplasia (HP:0006443)3.14459643
14Medulloblastoma (HP:0002885)3.11666997
15* Duodenal stenosis (HP:0100867)3.11560699
16* Small intestinal stenosis (HP:0012848)3.11560699
17* Abnormality of the ileum (HP:0001549)3.08342344
18Abnormal lung lobation (HP:0002101)2.98657400
19* Aplasia/Hypoplasia of the uvula (HP:0010293)2.96016611
20* Abnormality of the preputium (HP:0100587)2.95596062
21Deviation of the thumb (HP:0009603)2.94809347
22Proximal placement of thumb (HP:0009623)2.91614301
23Aplasia/Hypoplasia of the patella (HP:0006498)2.90746598
24Agnosia (HP:0010524)2.90497179
25Rhabdomyosarcoma (HP:0002859)2.87581647
26Abnormality of the labia minora (HP:0012880)2.86108109
27* Myelodysplasia (HP:0002863)2.82481750
28Impulsivity (HP:0100710)2.80959864
2911 pairs of ribs (HP:0000878)2.74121101
30Supernumerary spleens (HP:0009799)2.73913961
31Cortical dysplasia (HP:0002539)2.73567334
32Carpal bone hypoplasia (HP:0001498)2.69204309
33Abnormal number of incisors (HP:0011064)2.66296209
34* Absent radius (HP:0003974)2.65657508
35* Clubbing of toes (HP:0100760)2.65111448
36Basal cell carcinoma (HP:0002671)2.64346451
37Oral leukoplakia (HP:0002745)2.63534443
38High pitched voice (HP:0001620)2.62549100
39Nephroblastoma (Wilms tumor) (HP:0002667)2.59877562
40* Sloping forehead (HP:0000340)2.54893286
41Ectopic kidney (HP:0000086)2.52823306
42* Abnormality of the duodenum (HP:0002246)2.52821982
43Hypoplasia of the capital femoral epiphysis (HP:0003090)2.48877296
44* Cafe-au-lait spot (HP:0000957)2.48206750
45Duplicated collecting system (HP:0000081)2.45099744
46Squamous cell carcinoma (HP:0002860)2.41768377
47Intestinal atresia (HP:0011100)2.41128397
48* Absent forearm bone (HP:0003953)2.40933432
49* Aplasia involving forearm bones (HP:0009822)2.40933432
50Prominent nose (HP:0000448)2.40045816
51Embryonal renal neoplasm (HP:0011794)2.38965684
52Atresia of the external auditory canal (HP:0000413)2.36060108
53Rough bone trabeculation (HP:0100670)2.35245111
54Abnormality of the astrocytes (HP:0100707)2.31903957
55Astrocytoma (HP:0009592)2.31903957
56Neoplasm of the pancreas (HP:0002894)2.28171427
57Glioma (HP:0009733)2.27800438
58Aplastic anemia (HP:0001915)2.24369392
59Neoplasm of the colon (HP:0100273)2.24123852
60Premature graying of hair (HP:0002216)2.23807092
61* Bone marrow hypocellularity (HP:0005528)2.22768361
62Abnormality of the anterior horn cell (HP:0006802)2.19963673
63Degeneration of anterior horn cells (HP:0002398)2.19963673
64* Abnormality of the carotid arteries (HP:0005344)2.18552706
65Biliary tract neoplasm (HP:0100574)2.17223663
66Short 4th metacarpal (HP:0010044)2.15434000
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.15434000
68Horseshoe kidney (HP:0000085)2.14947363
69Ovarian neoplasm (HP:0100615)2.14644619
70* Absent thumb (HP:0009777)2.13539016
71Embryonal neoplasm (HP:0002898)2.12324381
72Abnormality of the calcaneus (HP:0008364)2.08549390
73Neoplasm of striated muscle (HP:0009728)2.08416434
74Abnormality of the renal collecting system (HP:0004742)2.07913669
75Acute encephalopathy (HP:0006846)2.06148818
76Acute necrotizing encephalopathy (HP:0006965)2.05944131
77Aplasia/Hypoplasia of the sternum (HP:0006714)2.04508057
78Irregular epiphyses (HP:0010582)2.04303263
79Cellular immunodeficiency (HP:0005374)2.03838386
80Neoplasm of the oral cavity (HP:0100649)2.00932244
81Abnormality of DNA repair (HP:0003254)2.00843908
82Absent epiphyses (HP:0010577)1.99993520
83Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.99993520
84Lymphoma (HP:0002665)1.99787322
85Small hand (HP:0200055)1.99658862
86Facial hemangioma (HP:0000329)1.96605515
87Missing ribs (HP:0000921)1.96393838
88Bifid tongue (HP:0010297)1.95150054
89Slender long bone (HP:0003100)1.94591451
90Abnormality of methionine metabolism (HP:0010901)1.91510836
91Ureteral duplication (HP:0000073)1.90716710
92Abnormality of cells of the erythroid lineage (HP:0012130)1.90583882
93Gastrointestinal carcinoma (HP:0002672)1.90574800
94Malignant gastrointestinal tract tumors (HP:0006749)1.90574800
95Amaurosis fugax (HP:0100576)1.90473655
96Entropion (HP:0000621)1.90340267
97* Tracheoesophageal fistula (HP:0002575)1.89462412
98Short thumb (HP:0009778)1.89260598
99* Choanal atresia (HP:0000453)1.88976756
100Abnormality of abdominal situs (HP:0011620)1.88671235
101Abdominal situs inversus (HP:0003363)1.88671235
102Abnormal biliary tract morphology (HP:0012440)1.86970936
103Abnormal mitochondria in muscle tissue (HP:0008316)1.86708712
104Intestinal polyposis (HP:0200008)1.85302918
105* Triphalangeal thumb (HP:0001199)1.84439033
106Hypoplastic pelvis (HP:0008839)1.83123564
107Cerebral hypomyelination (HP:0006808)1.82954395
108IgM deficiency (HP:0002850)1.82795295
109Microretrognathia (HP:0000308)1.82479469
110Abnormal auditory evoked potentials (HP:0006958)1.82065543
111Increased CSF lactate (HP:0002490)1.81256672
112Intestinal polyp (HP:0005266)1.80501678
113Stillbirth (HP:0003826)1.80245328
114* Arteriovenous malformation (HP:0100026)1.79618527
115Abnormality of the pons (HP:0007361)1.79238420
116Long clavicles (HP:0000890)1.79067619
117Aplasia/hypoplasia of the humerus (HP:0006507)1.78651978
118Oligodactyly (hands) (HP:0001180)1.78372584
119Abnormality of cochlea (HP:0000375)1.77913245
120Pancreatic cysts (HP:0001737)1.76169522
121Neoplasm of the small intestine (HP:0100833)1.76127838
122Increased hepatocellular lipid droplets (HP:0006565)1.75660090
123Hypoplasia of the pons (HP:0012110)1.75444729
124Secondary amenorrhea (HP:0000869)1.75257233
125Cerebral edema (HP:0002181)1.70148822
126Pancreatic islet-cell hyperplasia (HP:0004510)1.70020881
127Gastrointestinal atresia (HP:0002589)1.69546023
128Abnormality of the septum pellucidum (HP:0007375)1.67866226
129Mitochondrial inheritance (HP:0001427)1.67822146
130Pancreatic fibrosis (HP:0100732)1.66431693
131Breast carcinoma (HP:0003002)1.66145550
132Dandy-Walker malformation (HP:0001305)1.65541997
133Progressive macrocephaly (HP:0004481)1.65214932
134* Astigmatism (HP:0000483)1.63729960
135Absent septum pellucidum (HP:0001331)1.61720301
136Pancytopenia (HP:0001876)1.59578437
137Aplasia/Hypoplasia of the earlobes (HP:0009906)1.58719566
138Combined immunodeficiency (HP:0005387)1.58328237
139Abnormality of serum amino acid levels (HP:0003112)1.57920583
140Hepatocellular necrosis (HP:0001404)1.56748377
141Neoplasm of the adrenal cortex (HP:0100641)1.55927769
142* Oligohydramnios (HP:0001562)1.55703727
143Septo-optic dysplasia (HP:0100842)1.55683793
144Microvesicular hepatic steatosis (HP:0001414)1.54545395
145Hypoplasia of the fovea (HP:0007750)1.54202494
146Aplasia/Hypoplasia of the fovea (HP:0008060)1.54202494
147Increased serum pyruvate (HP:0003542)1.52278944
148Abnormality of the clitoris (HP:0000056)1.52098622

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.18617060
2BUB14.39340225
3WEE14.34223991
4NEK14.00844962
5TTK3.31396698
6NEK23.24508249
7EIF2AK12.70085196
8SRPK12.54385192
9TRIM282.49011391
10BRSK22.28855547
11PLK12.16134335
12PLK42.16010426
13AURKB2.05516627
14BMPR1B1.94129978
15VRK21.89449409
16PASK1.88855473
17NUAK11.88687242
18ACVR1B1.87229430
19TSSK61.86380294
20PLK31.84735144
21MST41.82168638
22ATR1.81412922
23STK101.74473434
24WNK31.74368691
25TESK21.74137635
26EIF2AK31.73665792
27CHEK21.63185558
28VRK11.59153316
29MAP3K81.55021607
30MKNK11.54788359
31SCYL21.46179797
32NME21.41675400
33TLK11.39730912
34ZAK1.39054924
35PAK41.37543746
36BRSK11.35909750
37RPS6KA41.34167702
38CDK41.33069184
39CLK11.31848714
40CDK71.31203971
41CCNB11.29135761
42CHEK11.28946236
43EEF2K1.28667726
44CDK121.22072651
45STK41.21244757
46MELK1.20611050
47TAF11.18094782
48CDK61.17403627
49AURKA1.14469963
50TNIK1.13769866
51RPS6KB21.12157395
52ATM1.11321792
53STK31.11253868
54PNCK1.10293311
55MKNK20.96821345
56NME10.95853363
57PDK20.93538451
58BCR0.90948042
59STK160.89429715
60STK38L0.86720200
61CDK20.85266339
62DYRK30.85238027
63BRAF0.85048544
64PLK20.83595352
65TGFBR10.80907159
66CDK10.72267447
67BRD40.70735604
68PIM10.70489889
69EIF2AK20.68490466
70PKN20.67819881
71LRRK20.67209656
72TESK10.67072329
73FRK0.63324539
74CDK30.62912148
75ALK0.61606428
76PBK0.56907863
77MAP2K30.55195209
78CSNK2A20.54750686
79MAPK130.53741671
80CSNK2A10.52385419
81CSNK1G10.52122003
82LATS10.49520080
83MAP4K10.48859960
84TTN0.47806480
85ERBB30.47108625
86FGFR10.46014783
87ERBB40.45886669
88MAP3K100.45050785
89LIMK10.44294995
90PAK10.43496511
91RPS6KA50.42777103
92MAP3K110.40407021
93MINK10.39564771
94STK390.38689943
95PRKDC0.37514622
96MARK30.37172021
97NEK90.36193198
98TRPM70.35932227
99KDR0.35244854
100EPHA20.35121907
101CDK80.33726719
102MAP3K120.31143437
103INSRR0.29758709
104FLT30.29577512
105MAP3K50.29255161
106GRK60.28909075
107CSNK1E0.28093004
108CSNK1G30.27900260
109PTK60.26013566
110STK240.25850180
111CSNK1D0.25682070
112CSNK1G20.25666559
113MTOR0.24955880
114CDK180.24947811
115YES10.24631617
116CDK150.24465938
117AKT20.24309943
118BTK0.23732929
119CDK11A0.22853541
120CSF1R0.22742083
121SIK30.22604103
122CSNK1A1L0.22507119
123EPHA40.21329377
124MAPK140.21008679
125OXSR10.19857620
126MAP3K40.19788595
127AKT10.19211293
128MAP3K60.18959530
129RPS6KB10.18859168
130PAK20.18625629
131RAF10.18269325

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.65901063
2Mismatch repair_Homo sapiens_hsa034304.85976482
3Cell cycle_Homo sapiens_hsa041103.49056705
4Homologous recombination_Homo sapiens_hsa034403.37380901
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.35182731
6Base excision repair_Homo sapiens_hsa034103.22527546
7RNA transport_Homo sapiens_hsa030133.17449177
8Spliceosome_Homo sapiens_hsa030403.13192949
9Nucleotide excision repair_Homo sapiens_hsa034202.99948226
10One carbon pool by folate_Homo sapiens_hsa006702.99183068
11* Fanconi anemia pathway_Homo sapiens_hsa034602.70590767
12Proteasome_Homo sapiens_hsa030502.60674873
13RNA polymerase_Homo sapiens_hsa030202.50339415
14Non-homologous end-joining_Homo sapiens_hsa034502.36799954
15Ribosome_Homo sapiens_hsa030102.29524918
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28431565
17Pyrimidine metabolism_Homo sapiens_hsa002402.21126334
18RNA degradation_Homo sapiens_hsa030181.99336768
19p53 signaling pathway_Homo sapiens_hsa041151.87701877
20mRNA surveillance pathway_Homo sapiens_hsa030151.74388321
21Basal transcription factors_Homo sapiens_hsa030221.68401420
22Systemic lupus erythematosus_Homo sapiens_hsa053221.63637380
23Propanoate metabolism_Homo sapiens_hsa006401.39741258
24Oocyte meiosis_Homo sapiens_hsa041141.38419927
25Oxidative phosphorylation_Homo sapiens_hsa001901.30433499
26Parkinsons disease_Homo sapiens_hsa050121.30151947
27Viral carcinogenesis_Homo sapiens_hsa052031.24902952
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23874087
29Steroid biosynthesis_Homo sapiens_hsa001001.18727295
30Purine metabolism_Homo sapiens_hsa002301.15431569
31Epstein-Barr virus infection_Homo sapiens_hsa051691.13954138
32Huntingtons disease_Homo sapiens_hsa050161.10866707
33Pyruvate metabolism_Homo sapiens_hsa006201.10232219
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05957523
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02892597
36MicroRNAs in cancer_Homo sapiens_hsa052060.95287661
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92614003
38HTLV-I infection_Homo sapiens_hsa051660.91399486
39Herpes simplex infection_Homo sapiens_hsa051680.90502496
40Antigen processing and presentation_Homo sapiens_hsa046120.88823247
41Thyroid cancer_Homo sapiens_hsa052160.88134139
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81999641
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81382864
44Fatty acid elongation_Homo sapiens_hsa000620.80667340
45Biosynthesis of amino acids_Homo sapiens_hsa012300.76796062
46Small cell lung cancer_Homo sapiens_hsa052220.75997791
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.72743733
48Alzheimers disease_Homo sapiens_hsa050100.66416165
49Alcoholism_Homo sapiens_hsa050340.63361576
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.60591672
51Colorectal cancer_Homo sapiens_hsa052100.58947962
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58147836
53Folate biosynthesis_Homo sapiens_hsa007900.57411193
54TGF-beta signaling pathway_Homo sapiens_hsa043500.56360201
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54331678
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52881204
57Selenocompound metabolism_Homo sapiens_hsa004500.52491638
58Legionellosis_Homo sapiens_hsa051340.48856909
59Vitamin B6 metabolism_Homo sapiens_hsa007500.48619432
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47886048
61Hippo signaling pathway_Homo sapiens_hsa043900.47748126
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47444204
63Primary immunodeficiency_Homo sapiens_hsa053400.47424637
64Hepatitis B_Homo sapiens_hsa051610.47280745
65Adherens junction_Homo sapiens_hsa045200.46953628
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45742943
67Metabolic pathways_Homo sapiens_hsa011000.44920169
68Protein export_Homo sapiens_hsa030600.44417780
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44044294
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.43876957
71Pentose phosphate pathway_Homo sapiens_hsa000300.43217839
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41738362
73Prostate cancer_Homo sapiens_hsa052150.41731885
74Apoptosis_Homo sapiens_hsa042100.41701426
75Basal cell carcinoma_Homo sapiens_hsa052170.38227624
76Shigellosis_Homo sapiens_hsa051310.37436150
77Carbon metabolism_Homo sapiens_hsa012000.37000191
78Wnt signaling pathway_Homo sapiens_hsa043100.36488769
79N-Glycan biosynthesis_Homo sapiens_hsa005100.36470589
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34481609
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33845211
82Bladder cancer_Homo sapiens_hsa052190.31623261
83mTOR signaling pathway_Homo sapiens_hsa041500.30383951
84Chronic myeloid leukemia_Homo sapiens_hsa052200.30095232
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29846570
86Nitrogen metabolism_Homo sapiens_hsa009100.28909750
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28764952
88Fatty acid metabolism_Homo sapiens_hsa012120.27910786
89Glutathione metabolism_Homo sapiens_hsa004800.27604047
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.27138919
91Viral myocarditis_Homo sapiens_hsa054160.26142788
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24780374
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24689366
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24362594
95Pathways in cancer_Homo sapiens_hsa052000.23509382
96Measles_Homo sapiens_hsa051620.23476658
97HIF-1 signaling pathway_Homo sapiens_hsa040660.22814171
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.21823367
99Caffeine metabolism_Homo sapiens_hsa002320.21677298
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21606029
101Tryptophan metabolism_Homo sapiens_hsa003800.21410415
102Butanoate metabolism_Homo sapiens_hsa006500.20016746
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.20009304
104Pancreatic cancer_Homo sapiens_hsa052120.18818266
105Fatty acid degradation_Homo sapiens_hsa000710.18184631
106Proteoglycans in cancer_Homo sapiens_hsa052050.17887105
107Non-small cell lung cancer_Homo sapiens_hsa052230.17707441
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17122322
109Hematopoietic cell lineage_Homo sapiens_hsa046400.16788624
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16203128
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.15592475
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.15449854
113Lysine degradation_Homo sapiens_hsa003100.14266469
114Peroxisome_Homo sapiens_hsa041460.13835223
115Phototransduction_Homo sapiens_hsa047440.13679240
116FoxO signaling pathway_Homo sapiens_hsa040680.13489135
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13304646
118Influenza A_Homo sapiens_hsa051640.13205257
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.13038678
120Endometrial cancer_Homo sapiens_hsa052130.12152350
121Sulfur metabolism_Homo sapiens_hsa009200.10595890
122beta-Alanine metabolism_Homo sapiens_hsa004100.10326843
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.10014200
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.09360171
125Renin-angiotensin system_Homo sapiens_hsa046140.09217339
126Arginine and proline metabolism_Homo sapiens_hsa003300.07930805
127Tight junction_Homo sapiens_hsa045300.07872933
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.07300372
129Olfactory transduction_Homo sapiens_hsa047400.07253906
130Notch signaling pathway_Homo sapiens_hsa043300.06942581
131Melanoma_Homo sapiens_hsa052180.06295321
132Hedgehog signaling pathway_Homo sapiens_hsa043400.04648675
133Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.04470710

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