FANCC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication checkpoint (GO:0000076)4.51783658
2mitotic sister chromatid cohesion (GO:0007064)4.21308299
3mitotic sister chromatid segregation (GO:0000070)4.03330575
4telomere maintenance via semi-conservative replication (GO:0032201)3.84103488
5sister chromatid segregation (GO:0000819)3.77516117
6DNA replication initiation (GO:0006270)3.77303139
7CENP-A containing nucleosome assembly (GO:0034080)3.73643716
8chromatin remodeling at centromere (GO:0031055)3.69523418
9regulation of centriole replication (GO:0046599)3.68630586
10DNA strand elongation involved in DNA replication (GO:0006271)3.68101848
11DNA strand elongation (GO:0022616)3.62152058
12telomere maintenance via recombination (GO:0000722)3.57397737
13attachment of spindle microtubules to kinetochore (GO:0008608)3.50122707
14L-serine metabolic process (GO:0006563)3.48141321
15DNA replication-independent nucleosome assembly (GO:0006336)3.40396352
16DNA replication-independent nucleosome organization (GO:0034724)3.40396352
17protein localization to kinetochore (GO:0034501)3.36872811
18mitotic chromosome condensation (GO:0007076)3.33540224
19meiotic chromosome segregation (GO:0045132)3.32025720
20mitotic recombination (GO:0006312)3.30721261
21paraxial mesoderm development (GO:0048339)3.28795865
22kinetochore organization (GO:0051383)3.27515039
23protein localization to chromosome, centromeric region (GO:0071459)3.22856250
24maturation of SSU-rRNA (GO:0030490)3.22431315
25DNA unwinding involved in DNA replication (GO:0006268)3.19932581
26regulation of centrosome cycle (GO:0046605)3.19705831
27regulation of centrosome duplication (GO:0010824)3.16437451
28chromosome condensation (GO:0030261)3.14979925
29mitotic metaphase plate congression (GO:0007080)3.14950517
30telomere maintenance via telomere lengthening (GO:0010833)3.14243692
31neutrophil activation involved in immune response (GO:0002283)3.09372859
32maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.08903854
33pore complex assembly (GO:0046931)3.06907089
34kinetochore assembly (GO:0051382)3.06821446
35sister chromatid cohesion (GO:0007062)3.02902977
36nucleotide-excision repair, DNA gap filling (GO:0006297)2.94870669
37regulation of nuclear cell cycle DNA replication (GO:0033262)2.94282595
38negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.93672191
39mismatch repair (GO:0006298)2.93324364
40DNA packaging (GO:0006323)2.91246981
41replication fork processing (GO:0031297)2.89308969
42telomere maintenance (GO:0000723)2.87887145
43regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.87635872
44protein K6-linked ubiquitination (GO:0085020)2.87543545
45DNA synthesis involved in DNA repair (GO:0000731)2.85958961
46telomere organization (GO:0032200)2.85839713
47regulation of DNA endoreduplication (GO:0032875)2.84552761
48histone exchange (GO:0043486)2.83449707
49mitotic nuclear envelope disassembly (GO:0007077)2.82878235
50positive regulation of gamma-delta T cell activation (GO:0046645)2.82498219
51mRNA cleavage (GO:0006379)2.82443853
52response to muramyl dipeptide (GO:0032495)2.79579528
53glycine metabolic process (GO:0006544)2.79445776
54regulation of translational fidelity (GO:0006450)2.78419999
55establishment of chromosome localization (GO:0051303)2.77799957
56DNA strand renaturation (GO:0000733)2.76985368
57non-recombinational repair (GO:0000726)2.76549978
58double-strand break repair via nonhomologous end joining (GO:0006303)2.76549978
59DNA deamination (GO:0045006)2.73721600
60metaphase plate congression (GO:0051310)2.72801062
61spindle assembly checkpoint (GO:0071173)2.70453673
62regulation of stem cell maintenance (GO:2000036)2.70297600
63chromatin assembly or disassembly (GO:0006333)2.69996535
64serine family amino acid biosynthetic process (GO:0009070)2.69640930
65NIK/NF-kappaB signaling (GO:0038061)2.68360523
66spindle checkpoint (GO:0031577)2.67232225
67microtubule depolymerization (GO:0007019)2.62315133
68regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.61292395
69regulation of mitotic spindle checkpoint (GO:1903504)2.61292395
70regulation of double-strand break repair via homologous recombination (GO:0010569)2.60590938
71DNA demethylation (GO:0080111)2.59088269
72negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.58801754
73heterochromatin organization (GO:0070828)2.58662759
74DNA geometric change (GO:0032392)2.57994215
75translesion synthesis (GO:0019985)2.57857276
76negative regulation of mitotic sister chromatid separation (GO:2000816)2.57393171
77negative regulation of mitotic sister chromatid segregation (GO:0033048)2.57393171
78negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.57393171
79negative regulation of sister chromatid segregation (GO:0033046)2.57393171
80nuclear envelope disassembly (GO:0051081)2.56367081
81membrane disassembly (GO:0030397)2.56367081
82regulation of transcription from RNA polymerase I promoter (GO:0006356)2.55485867
83negative regulation of chromosome segregation (GO:0051985)2.55481779
84nuclear pore complex assembly (GO:0051292)2.55382627
85DNA duplex unwinding (GO:0032508)2.54402010
86piRNA metabolic process (GO:0034587)2.54216162
87DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.54000057
88positive regulation of interleukin-1 beta secretion (GO:0050718)2.53528731
89mitotic spindle assembly checkpoint (GO:0007094)2.53291803
90serine family amino acid catabolic process (GO:0009071)2.53236182
91somatic hypermutation of immunoglobulin genes (GO:0016446)2.53136639
92somatic diversification of immune receptors via somatic mutation (GO:0002566)2.53136639
93biotin metabolic process (GO:0006768)2.52994957
94nuclear pore organization (GO:0006999)2.52986489
95neutrophil activation (GO:0042119)2.52756637
96synapsis (GO:0007129)2.52499921
97negative regulation of cell cycle G2/M phase transition (GO:1902750)2.52480730
98regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.50800341
99DNA replication-dependent nucleosome assembly (GO:0006335)2.50018969
100DNA replication-dependent nucleosome organization (GO:0034723)2.50018969
101regulation of meiosis I (GO:0060631)2.49760755
102regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.48699326
103microtubule nucleation (GO:0007020)2.47693144
104regulation of mitotic metaphase/anaphase transition (GO:0030071)2.47383380
105cytoplasmic mRNA processing body assembly (GO:0033962)2.47246764
106ATP-dependent chromatin remodeling (GO:0043044)2.45741347
107granulocyte activation (GO:0036230)2.45213551
108positive regulation of B cell differentiation (GO:0045579)2.44309476
109DNA damage response, signal transduction resulting in transcription (GO:0042772)2.44083007
110positive regulation of interferon-alpha production (GO:0032727)2.42861207
111regulation of RIG-I signaling pathway (GO:0039535)2.41915681
112regulation of spindle organization (GO:0090224)2.41320832
113spliceosomal snRNP assembly (GO:0000387)2.40995225
114pre-miRNA processing (GO:0031054)2.40610732
115mitotic spindle checkpoint (GO:0071174)2.40071621
116regulation of spindle checkpoint (GO:0090231)2.39662657
117maturation of 5.8S rRNA (GO:0000460)2.39506926
118spindle assembly involved in mitosis (GO:0090307)2.39260952
119regulation of chromosome segregation (GO:0051983)2.38593799
120DNA ligation (GO:0006266)2.38034847
121exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.36422330
122notochord development (GO:0030903)2.35946638
123IMP biosynthetic process (GO:0006188)2.35626681
124monoubiquitinated protein deubiquitination (GO:0035520)2.35332590
125DNA conformation change (GO:0071103)2.35276516
126nucleobase biosynthetic process (GO:0046112)2.34469419
127response to peptidoglycan (GO:0032494)2.34059008
128deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.33988637
129chromosome organization involved in meiosis (GO:0070192)2.33007242
130regulation of histone H3-K27 methylation (GO:0061085)2.32272520
131regulation of interleukin-1 beta secretion (GO:0050706)2.32215015
132immunoglobulin mediated immune response (GO:0016064)2.32042204
133inner cell mass cell proliferation (GO:0001833)2.31819096
134chromosome segregation (GO:0007059)2.31635993
135spindle organization (GO:0007051)2.31587304
136chromosome organization (GO:0051276)2.31066851
137nuclear envelope organization (GO:0006998)2.31015945
138serine family amino acid metabolic process (GO:0009069)2.30829985
139postreplication repair (GO:0006301)2.30168134
140fibroblast migration (GO:0010761)2.27333729
141histone H2A acetylation (GO:0043968)2.26385305
142folic acid metabolic process (GO:0046655)2.23985301
143regulation of sister chromatid cohesion (GO:0007063)2.21902557
144glutamine metabolic process (GO:0006541)2.21862709
145tetrahydrofolate metabolic process (GO:0046653)2.21419585
146positive regulation of chromosome segregation (GO:0051984)2.19103341
147erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.18940590
148L-phenylalanine metabolic process (GO:0006558)2.18940590
149oxidative demethylation (GO:0070989)2.18377825
150erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.18252753
151L-phenylalanine catabolic process (GO:0006559)2.18252753
152hippo signaling (GO:0035329)2.17260440
153spindle assembly (GO:0051225)2.16430628
154mitotic cell cycle (GO:0000278)2.15252962
155base-excision repair (GO:0006284)2.14683733
156reciprocal DNA recombination (GO:0035825)2.14271377
157reciprocal meiotic recombination (GO:0007131)2.14271377
158folic acid-containing compound biosynthetic process (GO:0009396)2.14095439

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.78998885
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.01058693
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21802598
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.90414123
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.70560863
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.50615946
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.50490126
8SCL_19346495_ChIP-Seq_HPC-7_Human2.44658380
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.21419775
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.19630188
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.14111979
12* E2F1_21310950_ChIP-Seq_MCF-7_Human2.11867110
13* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11151026
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07458209
15* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.05816190
16E2F7_22180533_ChIP-Seq_HELA_Human10.2876184
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96634530
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.93238514
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.92422293
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.89174989
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82032587
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.81952516
23PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.81220103
24FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78583834
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.76598049
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75723382
27VDR_23849224_ChIP-Seq_CD4+_Human1.75099418
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.74794200
29CIITA_25753668_ChIP-Seq_RAJI_Human1.72941648
30HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72343099
31SPI1_23547873_ChIP-Seq_NB4_Human1.71709353
32FOXP3_21729870_ChIP-Seq_TREG_Human1.70475309
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69237166
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67974995
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.66609230
36AR_21909140_ChIP-Seq_LNCAP_Human1.65977082
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.65840794
38MYC_22102868_ChIP-Seq_BL_Human1.64764560
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64271943
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62823998
41SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.57797472
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56849526
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.55361173
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.53477743
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53400800
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.53053270
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52292896
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.51882285
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50688429
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48492740
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48057399
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47472866
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45918618
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45800926
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44323629
56* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43732500
57XRN2_22483619_ChIP-Seq_HELA_Human1.43466150
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43104429
59VDR_21846776_ChIP-Seq_THP-1_Human1.41181112
60MYB_26560356_Chip-Seq_TH2_Human1.37947746
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37353303
62* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.37320262
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36691242
64STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.36603206
65* ELK1_19687146_ChIP-ChIP_HELA_Human1.36543425
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36021861
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32754071
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32350517
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31525313
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30475977
71NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28143834
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27396277
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26819929
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26041124
75DCP1A_22483619_ChIP-Seq_HELA_Human1.23025374
76ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22044446
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.21754056
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.20162932
79MYB_26560356_Chip-Seq_TH1_Human1.19145620
80MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17434355
81FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.13992732
82RUNX_20019798_ChIP-Seq_JUKART_Human1.13279851
83* TTF2_22483619_ChIP-Seq_HELA_Human1.11996246
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11695917
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.10911014
86* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10276282
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10038134
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09657221
89MAF_26560356_Chip-Seq_TH1_Human1.09088477
90VDR_24763502_ChIP-Seq_THP-1_Human1.08923593
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08818501
92BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07985764
93GABP_19822575_ChIP-Seq_HepG2_Human1.07141168
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06980047
95TFEB_21752829_ChIP-Seq_HELA_Human1.06946952
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06754540
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05337030
98GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04559227
99PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03230081
100CHD1_26751641_Chip-Seq_LNCaP_Human1.02794080
101* RUNX1_22412390_ChIP-Seq_EML_Mouse1.02317357
102HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00035335
103MYC_18940864_ChIP-ChIP_HL60_Human0.98802875
104FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97727697
105POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97678151
106EWS_26573619_Chip-Seq_HEK293_Human0.97414624
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.96777781
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96551629
109FUS_26573619_Chip-Seq_HEK293_Human0.96333893
110IRF1_19129219_ChIP-ChIP_H3396_Human0.96104989
111NANOG_21062744_ChIP-ChIP_HESCs_Human0.95587435
112KDM5A_27292631_Chip-Seq_BREAST_Human0.93856196
113ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93574632
114YY1_21170310_ChIP-Seq_MESCs_Mouse0.92783723
115NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92282723
116SPI1_23127762_ChIP-Seq_K562_Human0.91945592
117NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90634394
118THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90036962
119NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.90008339
120IGF1R_20145208_ChIP-Seq_DFB_Human0.89174613
121* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88543911
122SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88053597
123SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85128909
124E2F1_17053090_ChIP-ChIP_MCF-7_Human0.84528064
125UTX_26944678_Chip-Seq_JUKART_Human0.84428979
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83896934
127ZNF274_21170338_ChIP-Seq_K562_Hela0.83525343
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.83393916
129CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83120178
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82226995
131NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.81758638
132* HNF4A_19822575_ChIP-Seq_HepG2_Human0.81545388
133GATA6_25053715_ChIP-Seq_YYC3_Human0.79723029
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.79259979
135NANOG_16153702_ChIP-ChIP_HESCs_Human0.77982067
136STAT3_23295773_ChIP-Seq_U87_Human0.77184301
137* SOX2_16153702_ChIP-ChIP_HESCs_Human0.76799449
138HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.75579709
139KLF4_18555785_ChIP-Seq_MESCs_Mouse0.74637811
140PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73675374
141* SOX9_26525672_Chip-Seq_HEART_Mouse0.71629354
142NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.70903733
143GATA4_21415370_ChIP-Seq_HL-1_Mouse0.70358416
144FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.69646570
145ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.67616009
146CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.66775681
147GBX2_23144817_ChIP-Seq_PC3_Human0.66597822
148TBX5_21415370_ChIP-Seq_HL-1_Mouse0.64039068
149MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.63747942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010094_abnormal_chromosome_stability3.48879612
2MP0000569_abnormal_digit_pigmentation3.33161037
3MP0003111_abnormal_nucleus_morphology3.25265326
4MP0001835_abnormal_antigen_presentation3.05418519
5MP0008057_abnormal_DNA_replication3.04576288
6MP0002396_abnormal_hematopoietic_system3.02676941
7* MP0003077_abnormal_cell_cycle2.98731783
8MP0003693_abnormal_embryo_hatching2.74495011
9MP0008007_abnormal_cellular_replicative2.54699725
10MP0008058_abnormal_DNA_repair2.38564758
11MP0001661_extended_life_span1.99232965
12MP0001800_abnormal_humoral_immune1.96308358
13MP0004957_abnormal_blastocyst_morpholog1.92065743
14MP0003890_abnormal_embryonic-extraembry1.87206207
15MP0010307_abnormal_tumor_latency1.87048592
16MP0003763_abnormal_thymus_physiology1.87000128
17MP0008877_abnormal_DNA_methylation1.83165154
18* MP0002398_abnormal_bone_marrow1.80756086
19MP0002452_abnormal_antigen_presenting1.80287498
20MP0005174_abnormal_tail_pigmentation1.77826272
21MP0009785_altered_susceptibility_to1.75391896
22MP0002723_abnormal_immune_serum1.71895191
23MP0003436_decreased_susceptibility_to1.71324258
24MP0008932_abnormal_embryonic_tissue1.69342893
25MP0005000_abnormal_immune_tolerance1.68733945
26MP0002148_abnormal_hypersensitivity_rea1.68547621
27MP0003937_abnormal_limbs/digits/tail_de1.67127524
28MP0001819_abnormal_immune_cell1.66068003
29MP0002420_abnormal_adaptive_immunity1.65875723
30MP0002419_abnormal_innate_immunity1.64789921
31MP0005397_hematopoietic_system_phenotyp1.60702300
32MP0001545_abnormal_hematopoietic_system1.60702300
33MP0003646_muscle_fatigue1.60595222
34MP0005670_abnormal_white_adipose1.59680112
35MP0004233_abnormal_muscle_weight1.58397106
36MP0005671_abnormal_response_to1.56667020
37MP0000685_abnormal_immune_system1.56503774
38MP0005025_abnormal_response_to1.55920283
39MP0000703_abnormal_thymus_morphology1.55397415
40MP0005171_absent_coat_pigmentation1.54382251
41MP0000350_abnormal_cell_proliferation1.53709863
42MP0000490_abnormal_crypts_of1.52827456
43MP0000689_abnormal_spleen_morphology1.52607097
44MP0000716_abnormal_immune_system1.49965029
45MP0006292_abnormal_olfactory_placode1.46083648
46MP0005387_immune_system_phenotype1.45948618
47MP0001790_abnormal_immune_system1.45948618
48MP0002697_abnormal_eye_size1.44017376
49MP0002722_abnormal_immune_system1.43163485
50MP0004808_abnormal_hematopoietic_stem1.40067408
51* MP0002429_abnormal_blood_cell1.35499298
52MP0008260_abnormal_autophagy1.33278139
53MP0003950_abnormal_plasma_membrane1.31659317
54MP0002019_abnormal_tumor_incidence1.30722216
55MP0005075_abnormal_melanosome_morpholog1.30452492
56MP0004510_myositis1.29401908
57MP0009697_abnormal_copulation1.29161540
58MP0003942_abnormal_urinary_system1.28867546
59MP0010030_abnormal_orbit_morphology1.28542896
60MP0003984_embryonic_growth_retardation1.25749711
61MP0002277_abnormal_respiratory_mucosa1.25242727
62MP0002084_abnormal_developmental_patter1.23210971
63MP0009278_abnormal_bone_marrow1.23158044
64MP0002085_abnormal_embryonic_tissue1.22680280
65MP0004147_increased_porphyrin_level1.22305982
66MP0002405_respiratory_system_inflammati1.21895063
67MP0004197_abnormal_fetal_growth/weight/1.21284864
68MP0005365_abnormal_bile_salt1.20678100
69MP0002088_abnormal_embryonic_growth/wei1.20460529
70MP0002006_tumorigenesis1.20198349
71MP0003136_yellow_coat_color1.18330025
72MP0010368_abnormal_lymphatic_system1.16927075
73MP0003724_increased_susceptibility_to1.16697548
74MP0004145_abnormal_muscle_electrophysio1.15995706
75MP0002837_dystrophic_cardiac_calcinosis1.15821124
76* MP0001119_abnormal_female_reproductive1.15014724
77MP0000427_abnormal_hair_cycle1.14011941
78MP0000015_abnormal_ear_pigmentation1.13204804
79MP0010352_gastrointestinal_tract_polyps1.13070890
80MP0001529_abnormal_vocalization1.12837039
81MP0000465_gastrointestinal_hemorrhage1.11856444
82MP0003448_altered_tumor_morphology1.11844969
83MP0002166_altered_tumor_susceptibility1.10337302
84MP0000313_abnormal_cell_death1.09154897
85MP0001873_stomach_inflammation1.07381874
86MP0009672_abnormal_birth_weight1.06800282
87MP0005464_abnormal_platelet_physiology1.06727380
88MP0000858_altered_metastatic_potential1.05731581
89MP0001286_abnormal_eye_development1.04129956
90MP0002095_abnormal_skin_pigmentation1.03696340
91MP0002938_white_spotting1.02249507
92MP0010155_abnormal_intestine_physiology1.01815930
93MP0000749_muscle_degeneration1.00801260
94MP0004947_skin_inflammation0.99665172
95MP0003385_abnormal_body_wall0.99597780
96MP0003705_abnormal_hypodermis_morpholog0.99198927
97MP0003718_maternal_effect0.99074877
98MP0002249_abnormal_larynx_morphology0.97751560
99MP0005360_urolithiasis0.97319327
100MP0003119_abnormal_digestive_system0.97156064
101MP0001853_heart_inflammation0.95225886
102MP0003755_abnormal_palate_morphology0.94656664
103* MP0002160_abnormal_reproductive_system0.94464356
104MP0003861_abnormal_nervous_system0.94153716
105MP0002269_muscular_atrophy0.93931651
106MP0000566_synostosis0.93258459
107* MP0001145_abnormal_male_reproductive0.92597220
108MP0002163_abnormal_gland_morphology0.91735408
109MP0003786_premature_aging0.90875022
110MP0003943_abnormal_hepatobiliary_system0.90198110
111MP0005085_abnormal_gallbladder_physiolo0.89996211
112MP0001845_abnormal_inflammatory_respons0.89969863
113MP0001730_embryonic_growth_arrest0.89681142
114MP0005220_abnormal_exocrine_pancreas0.89459803
115MP0000371_diluted_coat_color0.87997736
116* MP0003698_abnormal_male_reproductive0.86887245
117MP0003567_abnormal_fetal_cardiomyocyte0.86726738
118MP0009333_abnormal_splenocyte_physiolog0.86457159
119* MP0002210_abnormal_sex_determination0.86347675
120MP0002086_abnormal_extraembryonic_tissu0.85962407
121* MP0000653_abnormal_sex_gland0.85959100
122MP0004381_abnormal_hair_follicle0.85802997
123MP0009703_decreased_birth_body0.85464337
124MP0002009_preneoplasia0.84907336
125MP0000631_abnormal_neuroendocrine_gland0.84572740
126MP0006035_abnormal_mitochondrial_morpho0.84063894
127MP0003941_abnormal_skin_development0.83837695
128MP0003935_abnormal_craniofacial_develop0.82798181
129* MP0001929_abnormal_gametogenesis0.82714123
130MP0008789_abnormal_olfactory_epithelium0.82586562
131MP0005395_other_phenotype0.80710173
132MP0000372_irregular_coat_pigmentation0.79716646
133MP0002933_joint_inflammation0.79504182
134MP0001293_anophthalmia0.79079228
135MP0006082_CNS_inflammation0.79036643
136MP0001299_abnormal_eye_distance/0.78902250
137MP0005076_abnormal_cell_differentiation0.78015622
138MP0002653_abnormal_ependyma_morphology0.77277293
139MP0002102_abnormal_ear_morphology0.76956147
140MP0005380_embryogenesis_phenotype0.76770167
141MP0001672_abnormal_embryogenesis/_devel0.76770167
142MP0002233_abnormal_nose_morphology0.76736560
143MP0005257_abnormal_intraocular_pressure0.76314051
144MP0002092_abnormal_eye_morphology0.76198317
145MP0001915_intracranial_hemorrhage0.76147917
146MP0003656_abnormal_erythrocyte_physiolo0.75829372
147MP0003123_paternal_imprinting0.75313378
148MP0002132_abnormal_respiratory_system0.73782565
149MP0003868_abnormal_feces_composition0.73254910
150MP0003828_pulmonary_edema0.73130094
151MP0005377_hearing/vestibular/ear_phenot0.72466957
152MP0003878_abnormal_ear_physiology0.72466957
153MP0000358_abnormal_cell_content/0.72253278
154MP0000747_muscle_weakness0.71545864
155MP0000003_abnormal_adipose_tissue0.71187273
156MP0008875_abnormal_xenobiotic_pharmacok0.71113275
157MP0005394_taste/olfaction_phenotype0.70808542
158MP0005499_abnormal_olfactory_system0.70808542
159MP0000778_abnormal_nervous_system0.69467231
160MP0002080_prenatal_lethality0.69441996
161MP0003115_abnormal_respiratory_system0.69334264
162MP0000432_abnormal_head_morphology0.69184209
163MP0002111_abnormal_tail_morphology0.68832433
164MP0001697_abnormal_embryo_size0.68002741
165* MP0002161_abnormal_fertility/fecundity0.67793222
166MP0000534_abnormal_ureter_morphology0.67749511
167MP0003195_calcinosis0.67512659
168MP0008995_early_reproductive_senescence0.67471191
169MP0002139_abnormal_hepatobiliary_system0.66983109

Predicted human phenotypes

RankGene SetZ-score
1* Chromosomal breakage induced by crosslinking agents (HP:0003221)5.61251576
2* Chromsome breakage (HP:0040012)5.53421986
3Birth length less than 3rd percentile (HP:0003561)3.92569962
4Impulsivity (HP:0100710)3.87007893
5Elevated erythrocyte sedimentation rate (HP:0003565)3.82013354
6Recurrent abscess formation (HP:0002722)3.53484676
7Prostate neoplasm (HP:0100787)3.52482127
8Recurrent bacterial skin infections (HP:0005406)3.40702786
9* Abnormality of chromosome stability (HP:0003220)3.25762606
10* Aplasia/Hypoplasia of the uvula (HP:0010293)3.17388644
11* Duplicated collecting system (HP:0000081)3.07775297
12* Clubbing of toes (HP:0100760)2.94282554
13* Ectopic kidney (HP:0000086)2.92626873
14Abnormality of the columella (HP:0009929)2.89569700
15* Meckel diverticulum (HP:0002245)2.85665034
16Abnormality of the fingertips (HP:0001211)2.84287129
17Acute myeloid leukemia (HP:0004808)2.83790966
18* Abnormality of the renal collecting system (HP:0004742)2.83604679
19* Reticulocytopenia (HP:0001896)2.82734589
20* Abnormality of the preputium (HP:0100587)2.77435890
21* Abnormality of the ileum (HP:0001549)2.74537506
22Mediastinal lymphadenopathy (HP:0100721)2.74477886
23Volvulus (HP:0002580)2.66294621
24Myositis (HP:0100614)2.64991579
25* Myelodysplasia (HP:0002863)2.59700067
26Retrobulbar optic neuritis (HP:0100654)2.57848602
27Optic neuritis (HP:0100653)2.57848602
28* Abnormality of the carotid arteries (HP:0005344)2.57334576
29* Small intestinal stenosis (HP:0012848)2.50499222
30* Duodenal stenosis (HP:0100867)2.50499222
31Patellar aplasia (HP:0006443)2.47592703
32Recurrent viral infections (HP:0004429)2.45222434
33Aplastic anemia (HP:0001915)2.45187676
34Depressed nasal tip (HP:0000437)2.43441188
35* Sloping forehead (HP:0000340)2.43267519
36Aplasia/Hypoplasia of the sternum (HP:0006714)2.39542313
37Leukocytosis (HP:0001974)2.35063478
38B lymphocytopenia (HP:0010976)2.33521310
39Abnormality of B cell number (HP:0010975)2.33521310
40* Pallor (HP:0000980)2.33378667
41Abnormality of the heme biosynthetic pathway (HP:0010472)2.24780527
42Abnormality of the prostate (HP:0008775)2.24336895
43Recurrent fungal infections (HP:0002841)2.23889697
44Periodontitis (HP:0000704)2.23392842
45* Bone marrow hypocellularity (HP:0005528)2.23251806
46Aplasia/Hypoplasia of the patella (HP:0006498)2.23244687
47Abnormality of the labia minora (HP:0012880)2.22197717
48Eczematoid dermatitis (HP:0000976)2.20520773
49Abnormality of cochlea (HP:0000375)2.19574818
50Acute lymphatic leukemia (HP:0006721)2.18495164
51Breast hypoplasia (HP:0003187)2.12952332
52Facial hemangioma (HP:0000329)2.11201353
53Heterotopia (HP:0002282)2.10685028
54Increased nuchal translucency (HP:0010880)2.10145875
55Hypobetalipoproteinemia (HP:0003563)2.03917212
56Lymphoma (HP:0002665)2.03191182
57Cortical dysplasia (HP:0002539)2.02987660
58Thyroiditis (HP:0100646)2.02614128
59Oral leukoplakia (HP:0002745)2.01758802
60Poikiloderma (HP:0001029)2.01406600
61Type I transferrin isoform profile (HP:0003642)1.98457235
62Overlapping toe (HP:0001845)1.97148476
63Ependymoma (HP:0002888)1.96677545
64Chronic otitis media (HP:0000389)1.95441255
65Abnormality of the astrocytes (HP:0100707)1.95359243
66Astrocytoma (HP:0009592)1.95359243
67Abnormal number of incisors (HP:0011064)1.94267266
68Abnormality of the parathyroid morphology (HP:0011766)1.94212880
69* Abnormality of the duodenum (HP:0002246)1.92753649
70Bifid tongue (HP:0010297)1.92189999
71Orchitis (HP:0100796)1.92121940
72Bicornuate uterus (HP:0000813)1.90273807
73Optic nerve coloboma (HP:0000588)1.89602698
74Cerebellar dysplasia (HP:0007033)1.89339738
75Delayed closure of the anterior fontanelle (HP:0001476)1.87661751
76Cleft eyelid (HP:0000625)1.86536185
77Stomatitis (HP:0010280)1.85749327
78Osteomyelitis (HP:0002754)1.85538008
79* Absent radius (HP:0003974)1.84461798
80Combined immunodeficiency (HP:0005387)1.84365240
81Abnormal lung lobation (HP:0002101)1.84313221
82Glioma (HP:0009733)1.84083835
83Recurrent pneumonia (HP:0006532)1.83586458
84High anterior hairline (HP:0009890)1.83409227
85Abnormality of the aortic arch (HP:0012303)1.83214367
86Hepatoblastoma (HP:0002884)1.81340500
87Oligodactyly (hands) (HP:0001180)1.80561701
88Recurrent skin infections (HP:0001581)1.79967163
89Vasculitis (HP:0002633)1.78261534
90Gingivitis (HP:0000230)1.77922960
91* Leukopenia (HP:0001882)1.77416896
92Severe combined immunodeficiency (HP:0004430)1.77112907
93Selective tooth agenesis (HP:0001592)1.76509528
94* Tracheoesophageal fistula (HP:0002575)1.75077376
95Bilateral microphthalmos (HP:0007633)1.74872806
96Abnormality of the nasal septum (HP:0000419)1.74737612
97Long clavicles (HP:0000890)1.74602792
98Abnormal number of erythroid precursors (HP:0012131)1.74056788
99* Absent forearm bone (HP:0003953)1.73937660
100* Aplasia involving forearm bones (HP:0009822)1.73937660
101Colon cancer (HP:0003003)1.73645376
102Cellulitis (HP:0100658)1.73341067
103Keratoconjunctivitis sicca (HP:0001097)1.73091927
104Panhypogammaglobulinemia (HP:0003139)1.72951011
105Nephroblastoma (Wilms tumor) (HP:0002667)1.71451973
106Stomach cancer (HP:0012126)1.71327730
107* Triphalangeal thumb (HP:0001199)1.70923548
108Eosinophilia (HP:0001880)1.70649940
109* Horseshoe kidney (HP:0000085)1.70484307
110IgM deficiency (HP:0002850)1.69379116
111Agnosia (HP:0010524)1.68203393
112Convex nasal ridge (HP:0000444)1.67483452
113Prominent nose (HP:0000448)1.66996507
114Diastasis recti (HP:0001540)1.66875949
115Granulocytopenia (HP:0001913)1.66232031
116Type 2 muscle fiber atrophy (HP:0003554)1.66147008
117Microtia (HP:0008551)1.66010701
118Microvesicular hepatic steatosis (HP:0001414)1.65448221
119Enlarged kidneys (HP:0000105)1.65404674
120Midline defect of the nose (HP:0004122)1.65387313
121Spinal muscular atrophy (HP:0007269)1.64973337
122Thrombocytosis (HP:0001894)1.63846403
123* Short thumb (HP:0009778)1.63779626
124Hyperglycinuria (HP:0003108)1.63305994
125Premature graying of hair (HP:0002216)1.63174980
126High pitched voice (HP:0001620)1.62833635
127Pulmonary fibrosis (HP:0002206)1.62526165
128Hypoplasia of the capital femoral epiphysis (HP:0003090)1.62347529
129Spondylolisthesis (HP:0003302)1.61957231
130Irregular epiphyses (HP:0010582)1.61686303
131Prolonged partial thromboplastin time (HP:0003645)1.61369009
132Medulloblastoma (HP:0002885)1.61150068
133T lymphocytopenia (HP:0005403)1.61070823
134Cellular immunodeficiency (HP:0005374)1.61040215
135Atresia of the external auditory canal (HP:0000413)1.60126789
136Abnormality of cells of the erythroid lineage (HP:0012130)1.60080473
137Congenital, generalized hypertrichosis (HP:0004540)1.59287886
138* Abnormality of DNA repair (HP:0003254)1.59107486
139Oligodactyly (HP:0012165)1.58579195
140Keratoconjunctivitis (HP:0001096)1.58266859
141Osteomalacia (HP:0002749)1.57966513
142Urethral obstruction (HP:0000796)1.57147938
143Anophthalmia (HP:0000528)1.56846033
144Abnormal pancreas size (HP:0012094)1.54724902
145Long foot (HP:0001833)1.54606358
146Obsessive-compulsive behavior (HP:0000722)1.54494412
147Sandal gap (HP:0001852)1.53146551
148Renovascular hypertension (HP:0100817)1.51552400
149Chronic hepatic failure (HP:0100626)1.48100927
150Genetic anticipation (HP:0003743)1.45819137
151Poor coordination (HP:0002370)1.45624612
152Morphological abnormality of the inner ear (HP:0011390)1.45360040
153Entropion (HP:0000621)1.42401285
154Hypoplasia of the pons (HP:0012110)1.41953219
155Facial cleft (HP:0002006)1.41936572
156Abnormality of the metopic suture (HP:0005556)1.41430760
157Hypolipoproteinemia (HP:0010981)1.41043568
158Capillary hemangiomas (HP:0005306)1.40689653
159Preaxial hand polydactyly (HP:0001177)1.40001685
160Hypoplastic iliac wings (HP:0002866)1.38861644
161Aplasia/Hypoplasia of the nipples (HP:0006709)1.38458233
162Abnormality of the intrinsic pathway (HP:0010989)1.38204493
163* Choanal atresia (HP:0000453)1.38004443
164Renal hypoplasia (HP:0000089)1.37751777
165Embryonal renal neoplasm (HP:0011794)1.37530291
166Abnormality of abdominal situs (HP:0011620)1.37202619
167Abdominal situs inversus (HP:0003363)1.37202619
168Septate vagina (HP:0001153)1.36314562
169Hypopigmentation of the fundus (HP:0007894)1.35656853
170Truncal obesity (HP:0001956)1.35365982
171* Cafe-au-lait spot (HP:0000957)1.34811553
172Postnatal growth retardation (HP:0008897)1.34653228

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK23.88764852
2BRD42.89750204
3NUAK12.61972920
4CDC72.57860413
5BUB12.54061252
6BLK2.48770385
7PBK2.43003502
8MAP3K142.28898608
9TLK12.27729366
10STK38L2.17671477
11WEE12.10166347
12NEK12.03083375
13FRK2.00849314
14KIT1.99705305
15FLT31.97658936
16BRSK11.97161014
17ZAK1.93683095
18LATS11.90549036
19MAP4K11.86081995
20WNK41.84102957
21PRPF4B1.79908542
22MST1R1.78140499
23ACVR1B1.77405735
24PDK21.71478108
25CDK121.70101208
26NEK21.68784412
27ATR1.65785769
28TTK1.61890408
29AKT31.61009461
30ICK1.58988453
31STK391.53098772
32CAMK1G1.52550751
33TYK21.51778627
34JAK31.51759113
35MKNK21.49185613
36IKBKB1.46825034
37CHEK21.45863072
38PNCK1.45842074
39TXK1.44545130
40MKNK11.44476174
41MET1.43216676
42PLK11.41936272
43CAMK1D1.40613906
44YES11.38258406
45NME11.38040637
46CSF1R1.33095358
47IRAK41.30801109
48SCYL21.29059656
49PLK41.26707885
50STK101.26364846
51CDK81.24547051
52SRPK11.19951336
53TEC1.19378131
54CHUK1.17835195
55MAP3K101.17800936
56MTOR1.13346863
57VRK11.13038408
58TBK11.12996018
59AURKB1.12971352
60BTK1.12493098
61PASK1.09951282
62PLK31.06710618
63RPS6KA41.06075398
64IRAK31.04325635
65IKBKE1.03249206
66TAOK31.03183008
67STK41.02657504
68DMPK1.02534060
69CDK71.01326804
70NLK1.00959340
71EIF2AK11.00569188
72ZAP700.98887237
73MELK0.96123748
74FGFR30.94203765
75STK160.89988814
76TRIB30.89452337
77CCNB10.89111449
78EIF2AK20.88401446
79NME20.88223427
80CHEK10.85356274
81BMPR1B0.84879063
82BCR0.83631283
83PIM10.83306947
84TRPM70.82512634
85CDK40.80883699
86EEF2K0.79595832
87EPHA20.78779840
88MUSK0.78278848
89EIF2AK30.77801839
90DYRK30.77800071
91RPS6KB20.75810522
92CLK10.74903617
93MARK30.73195083
94ATM0.71815690
95PRKAA10.71447949
96AURKA0.71073943
97SMG10.70606678
98MAPK110.68422133
99OBSCN0.67807565
100CSNK1A1L0.66835893
101JAK10.65051758
102SIK30.65048021
103MAP3K70.63803259
104RPS6KA50.63131785
105MAP3K80.63098913
106SYK0.62740743
107LYN0.61303416
108MAP2K30.60588987
109STK380.57489069
110CSNK1G10.56748058
111STK30.56058790
112WNK30.55886367
113PHKG10.55357174
114PHKG20.55357174
115TTN0.55323443
116PTK20.54710669
117LATS20.54676141
118LCK0.54112917
119MAP3K110.52766736
120MAP3K40.52214008
121CDK60.52180251
122PKN10.51232265
123HIPK20.51219380
124PRKAA20.50552477
125FGFR40.49405782
126LMTK20.49339800
127AKT20.48885113
128CDK10.48603987
129PRKCI0.48523231
130EPHA30.48216716
131CSNK1E0.47095623
132RPS6KB10.46877730
133CDK20.46003040
134TSSK60.45959992
135TAF10.44778673
136CDK90.44351453
137MAPKAPK30.44329228
138TRIM280.43855237
139PRKDC0.43612753
140CASK0.42902979
141VRK20.42685500
142BRAF0.42164977
143MAPKAPK20.41682901
144ITK0.41492272
145INSRR0.41168278
146GSK3B0.40140434
147MAPK140.39950147
148MAP3K30.39282097
149PRKD30.39211090
150TESK20.38554563
151ERBB20.37578456
152RPS6KA60.37517841
153AKT10.37144254
154FER0.36332848
155FGFR10.35978609
156MAP4K20.34864043

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.25093618
2Mismatch repair_Homo sapiens_hsa034303.12347812
3Homologous recombination_Homo sapiens_hsa034402.98254803
4Base excision repair_Homo sapiens_hsa034102.83124731
5Cell cycle_Homo sapiens_hsa041102.49527600
6Non-homologous end-joining_Homo sapiens_hsa034502.46856100
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.30399525
8* Fanconi anemia pathway_Homo sapiens_hsa034602.29886326
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.24087935
10Spliceosome_Homo sapiens_hsa030402.23655621
11One carbon pool by folate_Homo sapiens_hsa006702.13958867
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09089056
13RNA degradation_Homo sapiens_hsa030182.00486576
14RNA polymerase_Homo sapiens_hsa030201.98181710
15Pyrimidine metabolism_Homo sapiens_hsa002401.97937547
16Nucleotide excision repair_Homo sapiens_hsa034201.91000779
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.86019241
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.83553878
19RNA transport_Homo sapiens_hsa030131.80946989
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80354282
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78053774
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.74159876
23Ribosome_Homo sapiens_hsa030101.65129371
24Vitamin B6 metabolism_Homo sapiens_hsa007501.61788977
25Sulfur relay system_Homo sapiens_hsa041221.54078479
26Arginine biosynthesis_Homo sapiens_hsa002201.54053532
27Herpes simplex infection_Homo sapiens_hsa051681.53139250
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49536723
29Biosynthesis of amino acids_Homo sapiens_hsa012301.48505305
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46030998
31Primary immunodeficiency_Homo sapiens_hsa053401.45193190
32Basal transcription factors_Homo sapiens_hsa030221.43859926
33p53 signaling pathway_Homo sapiens_hsa041151.42062802
34Measles_Homo sapiens_hsa051621.41275904
35Butanoate metabolism_Homo sapiens_hsa006501.40445440
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38189072
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32823930
38Pyruvate metabolism_Homo sapiens_hsa006201.31888504
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30577524
40Leishmaniasis_Homo sapiens_hsa051401.28025719
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.27105458
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26516412
43Hematopoietic cell lineage_Homo sapiens_hsa046401.25669204
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24393994
45Legionellosis_Homo sapiens_hsa051341.24131616
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23831465
47Antigen processing and presentation_Homo sapiens_hsa046121.23319175
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22308870
49Influenza A_Homo sapiens_hsa051641.15833119
50Epstein-Barr virus infection_Homo sapiens_hsa051691.14481413
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12725842
52Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11373669
53Allograft rejection_Homo sapiens_hsa053301.10892906
54Primary bile acid biosynthesis_Homo sapiens_hsa001201.10689409
55Steroid biosynthesis_Homo sapiens_hsa001001.10411838
56Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10360615
57Propanoate metabolism_Homo sapiens_hsa006401.08518409
58Apoptosis_Homo sapiens_hsa042101.08012903
59Systemic lupus erythematosus_Homo sapiens_hsa053221.05603442
60Retinol metabolism_Homo sapiens_hsa008301.02360586
61Cyanoamino acid metabolism_Homo sapiens_hsa004601.01594506
62MicroRNAs in cancer_Homo sapiens_hsa052061.00327787
63Arginine and proline metabolism_Homo sapiens_hsa003300.98636641
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96738121
65Malaria_Homo sapiens_hsa051440.96631500
66Purine metabolism_Homo sapiens_hsa002300.94528694
67Carbon metabolism_Homo sapiens_hsa012000.94370048
68B cell receptor signaling pathway_Homo sapiens_hsa046620.93022440
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91355413
70mRNA surveillance pathway_Homo sapiens_hsa030150.90674519
71Graft-versus-host disease_Homo sapiens_hsa053320.90489996
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.90393685
73Hepatitis B_Homo sapiens_hsa051610.89946480
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88898211
75Osteoclast differentiation_Homo sapiens_hsa043800.88833138
76Viral carcinogenesis_Homo sapiens_hsa052030.87919590
77Caffeine metabolism_Homo sapiens_hsa002320.87688593
78Pertussis_Homo sapiens_hsa051330.87154593
79Phenylalanine metabolism_Homo sapiens_hsa003600.84975673
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.84082225
81Shigellosis_Homo sapiens_hsa051310.83347302
82Asthma_Homo sapiens_hsa053100.83021577
83Notch signaling pathway_Homo sapiens_hsa043300.82968811
84TNF signaling pathway_Homo sapiens_hsa046680.82865774
85ABC transporters_Homo sapiens_hsa020100.81551608
86HTLV-I infection_Homo sapiens_hsa051660.81131261
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80135990
88Hippo signaling pathway_Homo sapiens_hsa043900.79853110
89Fatty acid degradation_Homo sapiens_hsa000710.79641695
90Small cell lung cancer_Homo sapiens_hsa052220.77950886
91Proteasome_Homo sapiens_hsa030500.77223670
92Chemical carcinogenesis_Homo sapiens_hsa052040.76783679
93Basal cell carcinoma_Homo sapiens_hsa052170.75844145
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74733375
95Adherens junction_Homo sapiens_hsa045200.73877202
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73280046
97Tyrosine metabolism_Homo sapiens_hsa003500.73135426
98Tuberculosis_Homo sapiens_hsa051520.72322558
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71989948
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71942711
101Chronic myeloid leukemia_Homo sapiens_hsa052200.71470109
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71371652
103Staphylococcus aureus infection_Homo sapiens_hsa051500.71001234
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70423432
105Tryptophan metabolism_Homo sapiens_hsa003800.69369808
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69356305
107N-Glycan biosynthesis_Homo sapiens_hsa005100.68635016
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68240704
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66955104
110T cell receptor signaling pathway_Homo sapiens_hsa046600.63255852
111Toxoplasmosis_Homo sapiens_hsa051450.62668249
112Acute myeloid leukemia_Homo sapiens_hsa052210.60765396
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59667728
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59510421
115Autoimmune thyroid disease_Homo sapiens_hsa053200.57788627
116Linoleic acid metabolism_Homo sapiens_hsa005910.57392826
117Thyroid cancer_Homo sapiens_hsa052160.57079131
118Fatty acid metabolism_Homo sapiens_hsa012120.57016811
119Metabolic pathways_Homo sapiens_hsa011000.55947587
120Fructose and mannose metabolism_Homo sapiens_hsa000510.55661447
121Other glycan degradation_Homo sapiens_hsa005110.54794761
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54034991
123beta-Alanine metabolism_Homo sapiens_hsa004100.53753657
124Pancreatic cancer_Homo sapiens_hsa052120.51919924
125Oocyte meiosis_Homo sapiens_hsa041140.51867360
126Selenocompound metabolism_Homo sapiens_hsa004500.50999120
127Hedgehog signaling pathway_Homo sapiens_hsa043400.50955380
128Peroxisome_Homo sapiens_hsa041460.50837847
129AMPK signaling pathway_Homo sapiens_hsa041520.50787660
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50718648
131Glucagon signaling pathway_Homo sapiens_hsa049220.50684980
132Hepatitis C_Homo sapiens_hsa051600.50105568
133Bile secretion_Homo sapiens_hsa049760.49060817
134Rheumatoid arthritis_Homo sapiens_hsa053230.48890697
135Lysine degradation_Homo sapiens_hsa003100.48444839
136Starch and sucrose metabolism_Homo sapiens_hsa005000.48062563
137Viral myocarditis_Homo sapiens_hsa054160.46415243
138Vitamin digestion and absorption_Homo sapiens_hsa049770.45053004
139Protein export_Homo sapiens_hsa030600.44542665
140Pentose phosphate pathway_Homo sapiens_hsa000300.43107167
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43034478
142Salmonella infection_Homo sapiens_hsa051320.42916008
143Maturity onset diabetes of the young_Homo sapiens_hsa049500.42848637
144Tight junction_Homo sapiens_hsa045300.42401160
145Chemokine signaling pathway_Homo sapiens_hsa040620.42372312
146Complement and coagulation cascades_Homo sapiens_hsa046100.41359565
147Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39734868
148Circadian rhythm_Homo sapiens_hsa047100.38611671
149AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38015621
150Folate biosynthesis_Homo sapiens_hsa007900.37515612
151Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37496736
152Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37404547
153Drug metabolism - other enzymes_Homo sapiens_hsa009830.36562665
154Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35803926
155Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34707775
156Glycosaminoglycan degradation_Homo sapiens_hsa005310.34623001
157Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34225514
158Sphingolipid metabolism_Homo sapiens_hsa006000.33666906
159Phagosome_Homo sapiens_hsa041450.32759318
160TGF-beta signaling pathway_Homo sapiens_hsa043500.31855191
161Arachidonic acid metabolism_Homo sapiens_hsa005900.30505918
162Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29310604
163Central carbon metabolism in cancer_Homo sapiens_hsa052300.29273582
164Wnt signaling pathway_Homo sapiens_hsa043100.28598324
165Colorectal cancer_Homo sapiens_hsa052100.28570395
166Inositol phosphate metabolism_Homo sapiens_hsa005620.28266194

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