FANCD2OS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a conserved protein of unknown function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)6.86911713
2cell wall macromolecule metabolic process (GO:0044036)6.71254346
3cell wall macromolecule catabolic process (GO:0016998)6.71254346
4sperm motility (GO:0030317)6.43678170
5cilium or flagellum-dependent cell motility (GO:0001539)6.43089119
6acrosome assembly (GO:0001675)6.36279784
7sperm-egg recognition (GO:0035036)6.32298333
8axonemal dynein complex assembly (GO:0070286)6.01357746
9response to pheromone (GO:0019236)5.97121247
10multicellular organism reproduction (GO:0032504)5.88138118
11binding of sperm to zona pellucida (GO:0007339)5.81444599
12cell-cell recognition (GO:0009988)5.60680557
13protein polyglutamylation (GO:0018095)5.58581994
14epithelial cilium movement (GO:0003351)5.57507235
15spermatid development (GO:0007286)5.53266126
16motile cilium assembly (GO:0044458)5.42729716
17synaptonemal complex assembly (GO:0007130)5.41219765
18synaptonemal complex organization (GO:0070193)5.28537893
19cilium movement (GO:0003341)5.22009534
20mitotic metaphase plate congression (GO:0007080)5.14059533
21male meiosis (GO:0007140)5.08846468
22plasma membrane fusion (GO:0045026)5.07920214
23regulation of cilium movement (GO:0003352)5.07067633
24acrosome reaction (GO:0007340)5.00836336
25piRNA metabolic process (GO:0034587)4.98072027
26reproduction (GO:0000003)4.78692246
27behavioral response to nicotine (GO:0035095)4.72368701
28microtubule depolymerization (GO:0007019)4.71913704
29male meiosis I (GO:0007141)4.68052878
30negative regulation of telomere maintenance (GO:0032205)4.65451666
31protein localization to chromosome, centromeric region (GO:0071459)4.54691680
32meiosis I (GO:0007127)4.31113742
33DNA replication checkpoint (GO:0000076)4.25463713
34cellular ketone body metabolic process (GO:0046950)4.23828501
35protein K6-linked ubiquitination (GO:0085020)4.20577556
36chromosome organization involved in meiosis (GO:0070192)4.19464085
37monoubiquitinated protein deubiquitination (GO:0035520)4.16443267
38metaphase plate congression (GO:0051310)4.14685609
39DNA deamination (GO:0045006)4.13507461
40meiotic nuclear division (GO:0007126)4.12436542
41histone exchange (GO:0043486)4.09433376
42single fertilization (GO:0007338)4.04083434
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.02060407
44centriole replication (GO:0007099)3.96072229
45single strand break repair (GO:0000012)3.90712621
46chromosome condensation (GO:0030261)3.89551254
47protein localization to kinetochore (GO:0034501)3.89276240
48GTP biosynthetic process (GO:0006183)3.82473471
49chromatin remodeling at centromere (GO:0031055)3.79687964
50epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.78457080
51ketone body metabolic process (GO:1902224)3.76508110
52DNA methylation involved in gamete generation (GO:0043046)3.70195866
53DNA packaging (GO:0006323)3.70109333
54regulation of meiosis I (GO:0060631)3.63689543
55CENP-A containing nucleosome assembly (GO:0034080)3.63541674
56guanosine-containing compound biosynthetic process (GO:1901070)3.62959116
57nonmotile primary cilium assembly (GO:0035058)3.62368169
58UTP biosynthetic process (GO:0006228)3.59728318
59mitotic sister chromatid segregation (GO:0000070)3.59375976
60spermatogenesis (GO:0007283)3.58604829
61male gamete generation (GO:0048232)3.58535971
62kidney morphogenesis (GO:0060993)3.57253179
63establishment of chromosome localization (GO:0051303)3.52982710
64purine nucleobase biosynthetic process (GO:0009113)3.52580275
65nucleoside diphosphate phosphorylation (GO:0006165)3.48627861
66negative regulation of inclusion body assembly (GO:0090084)3.48287882
67attachment of spindle microtubules to kinetochore (GO:0008608)3.44647710
68regulation of microtubule-based movement (GO:0060632)3.44347445
69regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.43856315
70meiotic cell cycle process (GO:1903046)3.41312105
71seminiferous tubule development (GO:0072520)3.41220554
72ribosome biogenesis (GO:0042254)3.40859229
73regulation of chromosome segregation (GO:0051983)3.39371647
74gamete generation (GO:0007276)3.37122652
75fertilization (GO:0009566)3.36733912
76regulation of spindle checkpoint (GO:0090231)3.36419638
77establishment of protein localization to Golgi (GO:0072600)3.35744238
78meiotic cell cycle (GO:0051321)3.34831598
79DNA replication-independent nucleosome organization (GO:0034724)3.32617513
80DNA replication-independent nucleosome assembly (GO:0006336)3.32617513
81ventricular system development (GO:0021591)3.30367144
82sperm capacitation (GO:0048240)3.29571515
83chaperone-mediated protein complex assembly (GO:0051131)3.29264258
84regulation of spindle organization (GO:0090224)3.28268318
85regulation of inclusion body assembly (GO:0090083)3.26812424
86detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.25955263
87pyrimidine nucleobase catabolic process (GO:0006208)3.25443198
88protein localization to chromosome (GO:0034502)3.21151354
89cytidine metabolic process (GO:0046087)3.20951728
90cytidine catabolic process (GO:0006216)3.20951728
91cytidine deamination (GO:0009972)3.20951728
92protein targeting to Golgi (GO:0000042)3.18571316
93positive regulation of chromosome segregation (GO:0051984)3.17291272
94detection of light stimulus involved in sensory perception (GO:0050962)3.16789651
95detection of light stimulus involved in visual perception (GO:0050908)3.16789651
96ribosome assembly (GO:0042255)3.14646793
97nucleobase biosynthetic process (GO:0046112)3.13856849
98folic acid metabolic process (GO:0046655)3.12095309
99germ cell development (GO:0007281)3.11987009
100DNA replication initiation (GO:0006270)3.11164533
101UTP metabolic process (GO:0046051)3.11104931
102DNA replication-dependent nucleosome assembly (GO:0006335)3.09611136
103DNA replication-dependent nucleosome organization (GO:0034723)3.09611136
104negative regulation of mast cell activation (GO:0033004)3.09018943
105cilium morphogenesis (GO:0060271)3.08961445
106transcription elongation from RNA polymerase III promoter (GO:0006385)3.08908432
107termination of RNA polymerase III transcription (GO:0006386)3.08908432
108reciprocal DNA recombination (GO:0035825)3.08493504
109reciprocal meiotic recombination (GO:0007131)3.08493504
110maturation of 5.8S rRNA (GO:0000460)3.06474337
111positive regulation of oligodendrocyte differentiation (GO:0048714)3.05647225
112calcium ion-dependent exocytosis (GO:0017156)3.04488587
113rRNA methylation (GO:0031167)3.04396445
114mitotic chromosome condensation (GO:0007076)3.03346320
115pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.03170765
116cellular process involved in reproduction in multicellular organism (GO:0022412)3.03159270
117maturation of SSU-rRNA (GO:0030490)3.02931529
118negative regulation of synaptic transmission, GABAergic (GO:0032229)3.02360484
119mannosylation (GO:0097502)3.02349317
120regulation of exit from mitosis (GO:0007096)3.01381231
121meiotic chromosome segregation (GO:0045132)3.01100479
122kinetochore organization (GO:0051383)3.00727614
123mitotic sister chromatid cohesion (GO:0007064)2.99191798
124phosphatidylserine acyl-chain remodeling (GO:0036150)2.98306312
125centriole assembly (GO:0098534)2.97844705
126sister chromatid segregation (GO:0000819)2.97665101
127photoreceptor cell maintenance (GO:0045494)2.96946152
128pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.96818367
129microtubule severing (GO:0051013)2.95853560
130rRNA modification (GO:0000154)2.94590083
131ribonucleoprotein complex biogenesis (GO:0022613)2.94056436
132spliceosomal snRNP assembly (GO:0000387)2.93654834
133water-soluble vitamin biosynthetic process (GO:0042364)2.92778742
134spinal cord motor neuron differentiation (GO:0021522)2.91641991
135microtubule polymerization or depolymerization (GO:0031109)2.90612933
136phosphatidylinositol acyl-chain remodeling (GO:0036149)2.88403558
137lung-associated mesenchyme development (GO:0060484)2.86690916
138organic cation transport (GO:0015695)2.85321857
139indolalkylamine metabolic process (GO:0006586)2.84951529
140indole-containing compound catabolic process (GO:0042436)2.84609562
141indolalkylamine catabolic process (GO:0046218)2.84609562
142tryptophan catabolic process (GO:0006569)2.84609562
143behavioral response to ethanol (GO:0048149)2.84431570
144amine catabolic process (GO:0009310)2.83131207
145cellular biogenic amine catabolic process (GO:0042402)2.83131207
146negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83021386
147nucleobase catabolic process (GO:0046113)2.82115729
148coenzyme catabolic process (GO:0009109)2.79087684
149retrograde transport, vesicle recycling within Golgi (GO:0000301)2.78962700
150negative regulation of execution phase of apoptosis (GO:1900118)2.78308972
151somite development (GO:0061053)2.74900205
152peptidyl-histidine modification (GO:0018202)2.74201545
153reflex (GO:0060004)2.72809367
154nephron epithelium morphogenesis (GO:0072088)2.72528374
155nephron tubule morphogenesis (GO:0072078)2.72528374
156axoneme assembly (GO:0035082)2.72525934
157regulation of telomere maintenance (GO:0032204)2.72100189
158positive regulation of mitochondrial fission (GO:0090141)2.71744409
159positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.71725134
160phosphatidylethanolamine metabolic process (GO:0046337)2.71190503
161regulation of action potential (GO:0098900)2.70904507
162gamma-aminobutyric acid transport (GO:0015812)2.70787018
163positive regulation of growth hormone secretion (GO:0060124)2.70143828
164ribosomal small subunit assembly (GO:0000028)2.68886276
165cilium organization (GO:0044782)2.68756639
166ubiquinone biosynthetic process (GO:0006744)2.67425498
167kynurenine metabolic process (GO:0070189)2.67421445
168protein localization to Golgi apparatus (GO:0034067)2.66562412
169pyrimidine ribonucleoside catabolic process (GO:0046133)2.66331302
170positive regulation of meiosis (GO:0045836)2.66125743
171regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.65257224
172phosphatidylethanolamine biosynthetic process (GO:0006646)2.64938903
173cilium assembly (GO:0042384)2.63867671
174photoreceptor cell development (GO:0042461)2.63320935
175neuronal action potential (GO:0019228)2.62787663
176growth hormone secretion (GO:0030252)2.62603920
177L-fucose metabolic process (GO:0042354)2.62596161

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.95114176
2E2F7_22180533_ChIP-Seq_HELA_Human6.10720204
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.22042072
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.80445723
5EZH2_22144423_ChIP-Seq_EOC_Human3.61727942
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.47476816
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.44526907
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.26061019
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.09727539
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.03494556
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.01077376
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85159784
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.84571894
14IGF1R_20145208_ChIP-Seq_DFB_Human2.72088033
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.69740065
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.60260747
17AR_21909140_ChIP-Seq_LNCAP_Human2.58000533
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57333668
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.54905475
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52616562
21GBX2_23144817_ChIP-Seq_PC3_Human2.51784166
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.51473011
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46557362
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.32907706
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.29031290
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19237218
27FUS_26573619_Chip-Seq_HEK293_Human2.12878042
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07922573
29CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.02294659
30VDR_23849224_ChIP-Seq_CD4+_Human1.96532878
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89419459
32TAF15_26573619_Chip-Seq_HEK293_Human1.88570139
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88438519
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85548782
35KAP1_22055183_ChIP-Seq_ESCs_Mouse1.83908591
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77813620
37P300_19829295_ChIP-Seq_ESCs_Human1.75527518
38XRN2_22483619_ChIP-Seq_HELA_Human1.74868402
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.72527951
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71885666
41ER_23166858_ChIP-Seq_MCF-7_Human1.71735007
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.71264108
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71264108
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69470124
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.67811237
46CBP_20019798_ChIP-Seq_JUKART_Human1.67811237
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.64855065
48DCP1A_22483619_ChIP-Seq_HELA_Human1.64400900
49GABP_19822575_ChIP-Seq_HepG2_Human1.63617596
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62717833
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59025708
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58172689
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.57199796
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56246784
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.55993412
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.55274311
57FOXP3_21729870_ChIP-Seq_TREG_Human1.54689006
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54622658
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53863681
60TP53_22573176_ChIP-Seq_HFKS_Human1.52345239
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50823048
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50721421
63REST_21632747_ChIP-Seq_MESCs_Mouse1.50046607
64MYC_19829295_ChIP-Seq_ESCs_Human1.44609503
65TTF2_22483619_ChIP-Seq_HELA_Human1.44176312
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41556629
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40130598
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.39879582
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39203894
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38067330
71EWS_26573619_Chip-Seq_HEK293_Human1.36725768
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36606870
73NANOG_20526341_ChIP-Seq_ESCs_Human1.36497012
74AR_25329375_ChIP-Seq_VCAP_Human1.36430741
75KDM5A_27292631_Chip-Seq_BREAST_Human1.36172483
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.36005722
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35837352
78ERA_21632823_ChIP-Seq_H3396_Human1.35060520
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34943358
80FOXA1_25329375_ChIP-Seq_VCAP_Human1.33165104
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33165104
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30517666
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30445677
84RNF2_27304074_Chip-Seq_NSC_Mouse1.30428959
85AR_20517297_ChIP-Seq_VCAP_Human1.30419333
86ETV2_25802403_ChIP-Seq_MESCs_Mouse1.30288938
87NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29252946
88TAF2_19829295_ChIP-Seq_ESCs_Human1.28275243
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27450821
90EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.25919216
91EZH2_27294783_Chip-Seq_ESCs_Mouse1.25520258
92E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24863644
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24486405
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24091869
95AUTS2_25519132_ChIP-Seq_293T-REX_Human1.23204825
96SOX2_19829295_ChIP-Seq_ESCs_Human1.23045940
97NANOG_19829295_ChIP-Seq_ESCs_Human1.23045940
98HOXB7_26014856_ChIP-Seq_BT474_Human1.22578916
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.20265512
100SALL1_21062744_ChIP-ChIP_HESCs_Human1.19631057
101EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19506665
102NCOR_22424771_ChIP-Seq_293T_Human1.18898283
103STAT3_23295773_ChIP-Seq_U87_Human1.18612330
104EED_16625203_ChIP-ChIP_MESCs_Mouse1.18319188
105PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17882183
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17363926
107SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16790747
108REST_18959480_ChIP-ChIP_MESCs_Mouse1.16373727
109WDR5_24793694_ChIP-Seq_LNCAP_Human1.14719080
110SMAD3_21741376_ChIP-Seq_EPCs_Human1.13989018
111SMAD4_21799915_ChIP-Seq_A2780_Human1.13099505
112SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12707875
113GATA1_26923725_Chip-Seq_HPCs_Mouse1.11644093
114RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11323450
115JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10875214
116SMAD4_21741376_ChIP-Seq_EPCs_Human1.10184805
117DROSHA_22980978_ChIP-Seq_HELA_Human1.08812236
118TCF4_22108803_ChIP-Seq_LS180_Human1.08622186
119FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08427207
120EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08302170
121THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08032979
122JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06748257
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06560840
124ZNF263_19887448_ChIP-Seq_K562_Human1.06373252
125RUNX2_22187159_ChIP-Seq_PCA_Human1.06145174
126OCT4_20526341_ChIP-Seq_ESCs_Human1.05640376
127SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05589562
128KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05437386
129BCAT_22108803_ChIP-Seq_LS180_Human1.05306754
130RAC3_21632823_ChIP-Seq_H3396_Human1.05076045
131SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04846109
132GATA3_21867929_ChIP-Seq_CD8_Mouse1.04836140
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04763721
134ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03316856
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02747061
136STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02249322
137POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01971672
138TCF4_23295773_ChIP-Seq_U87_Human1.01765093
139CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01563400
140ELK1_19687146_ChIP-ChIP_HELA_Human1.01513731
141ERG_20517297_ChIP-Seq_VCAP_Human1.01338702
142FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99901599
143SRF_21415370_ChIP-Seq_HL-1_Mouse0.99872246
144P53_21459846_ChIP-Seq_SAOS-2_Human0.99540699
145MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99323515
146E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98209146
147NFE2_27457419_Chip-Seq_LIVER_Mouse0.97283934
148TP63_19390658_ChIP-ChIP_HaCaT_Human0.95731107
149SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95494244
150GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94576813
151MYC_18940864_ChIP-ChIP_HL60_Human0.94028152
152ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92927756
153PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92645782
154YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92631080
155FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89484160
156SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86897394
157SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86440098
158VDR_22108803_ChIP-Seq_LS180_Human0.85107650
159TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.83312682
160KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.82577536
161SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82432653
162EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81365282
163STAT1_17558387_ChIP-Seq_HELA_Human0.81345666
164DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79769446
165PCGF2_27294783_Chip-Seq_NPCs_Mouse0.79727581
166NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79008400
167YY1_22570637_ChIP-Seq_MALME-3M_Human0.77566694
168NANOG_21062744_ChIP-ChIP_HESCs_Human0.76212240
169SOX2_22085726_ChIP-Seq_NPCs_Mouse0.75763432
170CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.73781374
171HOXB4_20404135_ChIP-ChIP_EML_Mouse0.71416435
172LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.71036738
173GATA3_21867929_ChIP-Seq_TH1_Mouse0.70895603
174IRF1_19129219_ChIP-ChIP_H3396_Human0.69994213
175RARA_24833708_ChIP-Seq_LIVER_Mouse0.68868799
176FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.67384760
177POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.67296218
178ZNF274_21170338_ChIP-Seq_K562_Hela0.65661768
179SRY_22984422_ChIP-ChIP_TESTIS_Rat0.65630532
180NOTCH1_21737748_ChIP-Seq_TLL_Human0.65146087
181FLI1_21867929_ChIP-Seq_CD8_Mouse0.65067572
182KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.64839813

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.90840668
2MP0003693_abnormal_embryo_hatching5.14728378
3MP0003111_abnormal_nucleus_morphology4.53629163
4MP0008877_abnormal_DNA_methylation4.27117664
5MP0010094_abnormal_chromosome_stability4.07969452
6MP0001929_abnormal_gametogenesis4.06596748
7MP0004957_abnormal_blastocyst_morpholog3.95336759
8MP0003698_abnormal_male_reproductive3.80701941
9MP0003077_abnormal_cell_cycle3.37093140
10MP0002210_abnormal_sex_determination3.22369830
11MP0008058_abnormal_DNA_repair3.12846879
12MP0008057_abnormal_DNA_replication2.93729021
13MP0002653_abnormal_ependyma_morphology2.81125436
14MP0001145_abnormal_male_reproductive2.77116273
15MP0003718_maternal_effect2.69559866
16MP0001986_abnormal_taste_sensitivity2.59297986
17MP0005646_abnormal_pituitary_gland2.52994821
18MP0003646_muscle_fatigue2.48596872
19MP0000653_abnormal_sex_gland2.47563993
20MP0001485_abnormal_pinna_reflex2.43664756
21MP0008932_abnormal_embryonic_tissue2.43555289
22MP0003123_paternal_imprinting2.40338033
23MP0005551_abnormal_eye_electrophysiolog2.28066498
24MP0003786_premature_aging2.22855552
25MP0002161_abnormal_fertility/fecundity2.22738283
26MP0001968_abnormal_touch/_nociception2.22724395
27MP0003880_abnormal_central_pattern2.15070015
28MP0001730_embryonic_growth_arrest1.98046685
29MP0001486_abnormal_startle_reflex1.96897331
30MP0008007_abnormal_cellular_replicative1.94938715
31MP0005423_abnormal_somatic_nervous1.86147314
32MP0005253_abnormal_eye_physiology1.81443053
33MP0002272_abnormal_nervous_system1.74018177
34MP0003787_abnormal_imprinting1.70864001
35MP0004142_abnormal_muscle_tone1.68915307
36MP0001529_abnormal_vocalization1.67831218
37MP0002735_abnormal_chemical_nociception1.66932657
38MP0002876_abnormal_thyroid_physiology1.66574975
39MP0008789_abnormal_olfactory_epithelium1.66194653
40MP0004742_abnormal_vestibular_system1.65724652
41MP0005645_abnormal_hypothalamus_physiol1.64054279
42MP0002736_abnormal_nociception_after1.61997848
43MP0002102_abnormal_ear_morphology1.61708831
44MP0009745_abnormal_behavioral_response1.60896728
45MP0002638_abnormal_pupillary_reflex1.58312485
46MP0009046_muscle_twitch1.57332015
47MP0008872_abnormal_physiological_respon1.57001872
48MP0002837_dystrophic_cardiac_calcinosis1.52656467
49MP0002160_abnormal_reproductive_system1.52501237
50MP0005174_abnormal_tail_pigmentation1.51576685
51MP0002277_abnormal_respiratory_mucosa1.45214005
52MP0000350_abnormal_cell_proliferation1.44217694
53MP0008875_abnormal_xenobiotic_pharmacok1.41993651
54MP0005380_embryogenesis_phenotype1.40938128
55MP0001672_abnormal_embryogenesis/_devel1.40938128
56MP0001697_abnormal_embryo_size1.35801208
57MP0003315_abnormal_perineum_morphology1.35455778
58MP0006072_abnormal_retinal_apoptosis1.35341318
59MP0000778_abnormal_nervous_system1.34694315
60MP0003136_yellow_coat_color1.34078941
61MP0010307_abnormal_tumor_latency1.33078067
62MP0002138_abnormal_hepatobiliary_system1.32160960
63MP0006276_abnormal_autonomic_nervous1.31974032
64MP0008995_early_reproductive_senescence1.28486245
65MP0006292_abnormal_olfactory_placode1.24791184
66MP0000026_abnormal_inner_ear1.24774886
67MP0001984_abnormal_olfaction1.23269816
68MP0005499_abnormal_olfactory_system1.23150369
69MP0005394_taste/olfaction_phenotype1.23150369
70MP0005248_abnormal_Harderian_gland1.21588011
71MP0002234_abnormal_pharynx_morphology1.20967188
72MP0003984_embryonic_growth_retardation1.19463544
73MP0002282_abnormal_trachea_morphology1.18089149
74MP0005084_abnormal_gallbladder_morpholo1.17794782
75MP0000631_abnormal_neuroendocrine_gland1.17692350
76MP0000049_abnormal_middle_ear1.16991205
77MP0001119_abnormal_female_reproductive1.16844171
78MP0005379_endocrine/exocrine_gland_phen1.16689206
79MP0002938_white_spotting1.16531449
80MP0002080_prenatal_lethality1.16436890
81MP0002085_abnormal_embryonic_tissue1.16221908
82MP0003122_maternal_imprinting1.15855569
83MP0002572_abnormal_emotion/affect_behav1.15721013
84MP0004885_abnormal_endolymph1.15200591
85MP0002088_abnormal_embryonic_growth/wei1.14648202
86MP0001963_abnormal_hearing_physiology1.13434043
87MP0005167_abnormal_blood-brain_barrier1.12372767
88MP0002557_abnormal_social/conspecific_i1.10609912
89MP0001905_abnormal_dopamine_level1.10581192
90MP0008260_abnormal_autophagy1.09972026
91MP0003938_abnormal_ear_development1.09558930
92MP0002064_seizures1.08981814
93MP0005195_abnormal_posterior_eye1.08548757
94MP0005389_reproductive_system_phenotype1.08059257
95MP0002733_abnormal_thermal_nociception1.07694241
96MP0000313_abnormal_cell_death1.07325398
97MP0001502_abnormal_circadian_rhythm1.06252897
98MP0000490_abnormal_crypts_of1.06206400
99MP0003195_calcinosis1.06096512
100MP0001970_abnormal_pain_threshold1.04872819
101MP0003635_abnormal_synaptic_transmissio1.02899773
102MP0002752_abnormal_somatic_nervous1.02475303
103MP0001661_extended_life_span1.02462558
104MP0002067_abnormal_sensory_capabilities1.01361824
105MP0001293_anophthalmia1.00935732
106MP0002084_abnormal_developmental_patter1.00644853
107MP0002229_neurodegeneration0.99549136
108MP0000955_abnormal_spinal_cord0.97927511
109MP0002063_abnormal_learning/memory/cond0.94976309
110MP0004133_heterotaxia0.94603811
111MP0003699_abnormal_female_reproductive0.93676061
112MP0002396_abnormal_hematopoietic_system0.93178364
113MP0003878_abnormal_ear_physiology0.92932117
114MP0005377_hearing/vestibular/ear_phenot0.92932117
115MP0005391_vision/eye_phenotype0.92806167
116MP0008775_abnormal_heart_ventricle0.91116115
117MP0001188_hyperpigmentation0.90987666
118MP0005395_other_phenotype0.90566869
119MP0002132_abnormal_respiratory_system0.90405261
120MP0002928_abnormal_bile_duct0.86946668
121MP0000358_abnormal_cell_content/0.86886967
122MP0002734_abnormal_mechanical_nocicepti0.86847577
123MP0002822_catalepsy0.86506516
124MP0002163_abnormal_gland_morphology0.85405722
125MP0005397_hematopoietic_system_phenotyp0.83420848
126MP0001545_abnormal_hematopoietic_system0.83420848
127MP0003937_abnormal_limbs/digits/tail_de0.82694967
128MP0006036_abnormal_mitochondrial_physio0.81946239
129MP0002019_abnormal_tumor_incidence0.80967877
130MP0001501_abnormal_sleep_pattern0.80348134
131MP0002086_abnormal_extraembryonic_tissu0.79978208
132MP0001324_abnormal_eye_pigmentation0.79604685
133MP0005451_abnormal_body_composition0.79436932
134MP0009672_abnormal_birth_weight0.69968360
135MP0004808_abnormal_hematopoietic_stem0.69565582
136MP0006035_abnormal_mitochondrial_morpho0.66189669
137MP0003941_abnormal_skin_development0.65808067
138MP0005670_abnormal_white_adipose0.65709199
139MP0009697_abnormal_copulation0.64698584
140MP0001764_abnormal_homeostasis0.63995567
141MP0003186_abnormal_redox_activity0.63394930
142MP0003011_delayed_dark_adaptation0.62242497
143MP0001919_abnormal_reproductive_system0.61313233
144MP0005623_abnormal_meninges_morphology0.59813141
145MP0003221_abnormal_cardiomyocyte_apopto0.59742809
146MP0002009_preneoplasia0.59062434
147MP0003121_genomic_imprinting0.57105366
148MP0009379_abnormal_foot_pigmentation0.54949868
149MP0002092_abnormal_eye_morphology0.54316953
150MP0004233_abnormal_muscle_weight0.54068174
151MP0003936_abnormal_reproductive_system0.53893339
152MP0005636_abnormal_mineral_homeostasis0.51933202
153MP0004197_abnormal_fetal_growth/weight/0.50728687
154MP0002095_abnormal_skin_pigmentation0.49043268
155MP0009333_abnormal_splenocyte_physiolog0.48364270
156MP0003119_abnormal_digestive_system0.48256461
157MP0003861_abnormal_nervous_system0.47754056
158MP0005408_hypopigmentation0.47261644
159MP0000432_abnormal_head_morphology0.47073787
160MP0005647_abnormal_sex_gland0.45563786
161MP0000703_abnormal_thymus_morphology0.44723772
162MP0000015_abnormal_ear_pigmentation0.44372075
163MP0003656_abnormal_erythrocyte_physiolo0.43362890
164MP0005384_cellular_phenotype0.41467839
165MP0003567_abnormal_fetal_cardiomyocyte0.41346195
166MP0001727_abnormal_embryo_implantation0.40914246
167MP0000428_abnormal_craniofacial_morphol0.40158074
168MP0009703_decreased_birth_body0.38862647
169MP0004019_abnormal_vitamin_homeostasis0.38742070
170MP0000750_abnormal_muscle_regeneration0.38523121
171MP0002127_abnormal_cardiovascular_syste0.36514622

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.68498205
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.75123520
3Absent/shortened dynein arms (HP:0200106)7.75123520
4Abnormal respiratory motile cilium physiology (HP:0012261)7.45910590
5Abnormal respiratory epithelium morphology (HP:0012253)6.67766574
6Abnormal respiratory motile cilium morphology (HP:0005938)6.67766574
7Abnormal ciliary motility (HP:0012262)6.40183909
8Rhinitis (HP:0012384)6.18250361
9Chronic bronchitis (HP:0004469)5.06409410
10Impulsivity (HP:0100710)4.37528705
11Infertility (HP:0000789)4.23916354
12True hermaphroditism (HP:0010459)4.22659854
13Abnormal spermatogenesis (HP:0008669)4.11197854
14Birth length less than 3rd percentile (HP:0003561)3.93440499
15Pendular nystagmus (HP:0012043)3.87286102
16Attenuation of retinal blood vessels (HP:0007843)3.83588594
17Male infertility (HP:0003251)3.76286865
18Chronic hepatic failure (HP:0100626)3.67706319
19Breast hypoplasia (HP:0003187)3.64173650
20Bronchiectasis (HP:0002110)3.59560749
21Nasal polyposis (HP:0100582)3.51678827
22Decreased central vision (HP:0007663)3.48138563
23Abnormal rod and cone electroretinograms (HP:0008323)3.26858043
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.25233486
25Congenital stationary night blindness (HP:0007642)3.16894393
26Chromsome breakage (HP:0040012)3.07565629
27Azoospermia (HP:0000027)3.06496556
28Bronchitis (HP:0012387)3.05785918
29Carpal bone hypoplasia (HP:0001498)3.02177272
30Sclerocornea (HP:0000647)2.97926066
31Type II lissencephaly (HP:0007260)2.92098800
32Abolished electroretinogram (ERG) (HP:0000550)2.86733705
33Anencephaly (HP:0002323)2.85581892
34Cystic liver disease (HP:0006706)2.81710333
35Bony spicule pigmentary retinopathy (HP:0007737)2.81397229
36Severe visual impairment (HP:0001141)2.78034112
37Tubular atrophy (HP:0000092)2.75123532
38Abnormality of the renal cortex (HP:0011035)2.72749305
39Abnormality of the nasal mucosa (HP:0000433)2.69702296
40Nephronophthisis (HP:0000090)2.69603464
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.67308323
42Pancreatic fibrosis (HP:0100732)2.67128934
43Microglossia (HP:0000171)2.65999663
44Abnormality of the preputium (HP:0100587)2.65198166
45Reticulocytopenia (HP:0001896)2.63730328
46Optic nerve hypoplasia (HP:0000609)2.63472514
47Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.63310691
48Ureteral duplication (HP:0000073)2.62716559
49Meckel diverticulum (HP:0002245)2.62112164
50Abnormality of cells of the erythroid lineage (HP:0012130)2.61756953
51Cerebral hypomyelination (HP:0006808)2.61388510
52Abnormal number of erythroid precursors (HP:0012131)2.58830761
53Patellar aplasia (HP:0006443)2.57585208
54Absent radius (HP:0003974)2.56165565
55Retinal dysplasia (HP:0007973)2.55960250
56Recurrent sinusitis (HP:0011108)2.54705894
57Hyperglycinemia (HP:0002154)2.54033321
58Aplasia/Hypoplasia of the patella (HP:0006498)2.51805827
59Rough bone trabeculation (HP:0100670)2.47604201
60Abnormality of the ileum (HP:0001549)2.43862705
61Median cleft lip (HP:0000161)2.43134430
62Colon cancer (HP:0003003)2.42674776
63Abnormality of chromosome stability (HP:0003220)2.39915018
64Facial cleft (HP:0002006)2.39834603
65Absent forearm bone (HP:0003953)2.39466272
66Aplasia involving forearm bones (HP:0009822)2.39466272
67Abnormal drinking behavior (HP:0030082)2.38621340
68Polydipsia (HP:0001959)2.38621340
69Increased corneal curvature (HP:0100692)2.37458134
70Keratoconus (HP:0000563)2.37458134
71Absent thumb (HP:0009777)2.36998401
72Chorioretinal atrophy (HP:0000533)2.34443290
73Congenital hepatic fibrosis (HP:0002612)2.32213537
74Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.31234634
75Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.30772384
76Gait imbalance (HP:0002141)2.29982976
77Secondary amenorrhea (HP:0000869)2.27813613
78Aplasia/Hypoplasia of the uvula (HP:0010293)2.26879796
79Hypoplasia of the capital femoral epiphysis (HP:0003090)2.24751643
80Abnormality of macular pigmentation (HP:0008002)2.24722592
81Tubulointerstitial abnormality (HP:0001969)2.22262771
82Abnormality of midbrain morphology (HP:0002418)2.22114504
83Molar tooth sign on MRI (HP:0002419)2.22114504
84Congenital primary aphakia (HP:0007707)2.21718100
85Oral leukoplakia (HP:0002745)2.19834456
86Ectopic kidney (HP:0000086)2.16707568
87Male pseudohermaphroditism (HP:0000037)2.15759742
88Horseshoe kidney (HP:0000085)2.14758357
89Facial hemangioma (HP:0000329)2.14073616
90Hyperventilation (HP:0002883)2.13738521
91Polyuria (HP:0000103)2.12241563
92Recurrent otitis media (HP:0000403)2.12155464
93Duplicated collecting system (HP:0000081)2.10575343
94Cleft eyelid (HP:0000625)2.08884353
95Pancreatic cysts (HP:0001737)2.08840193
96Inability to walk (HP:0002540)2.08831565
97Polyphagia (HP:0002591)2.07578573
98Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06754747
99Lissencephaly (HP:0001339)2.05770091
100Agnosia (HP:0010524)2.04794067
101Cerebellar dysplasia (HP:0007033)2.04749593
102Nephrogenic diabetes insipidus (HP:0009806)2.03428572
103Methylmalonic acidemia (HP:0002912)2.02988885
104Hyperglycinuria (HP:0003108)2.02795758
105Acute necrotizing encephalopathy (HP:0006965)2.02340807
106Small intestinal stenosis (HP:0012848)2.02240073
107Duodenal stenosis (HP:0100867)2.02240073
108Methylmalonic aciduria (HP:0012120)2.01199040
109Occipital encephalocele (HP:0002085)2.01168886
110Abnormality of lateral ventricle (HP:0030047)2.01126005
111Septo-optic dysplasia (HP:0100842)2.01067631
112Sloping forehead (HP:0000340)2.00071876
113Progressive cerebellar ataxia (HP:0002073)1.98912382
114Abnormality of the anterior horn cell (HP:0006802)1.97744891
115Degeneration of anterior horn cells (HP:0002398)1.97744891
116Mitochondrial inheritance (HP:0001427)1.93546322
117Supernumerary spleens (HP:0009799)1.93192677
118Anophthalmia (HP:0000528)1.91420822
119Tubulointerstitial nephritis (HP:0001970)1.90592277
120Rib fusion (HP:0000902)1.89829236
121Double outlet right ventricle (HP:0001719)1.88725952
122Congenital malformation of the right heart (HP:0011723)1.88725952
123Aplasia/Hypoplasia of the tongue (HP:0010295)1.88527717
124Premature ovarian failure (HP:0008209)1.87884975
125Thyroid-stimulating hormone excess (HP:0002925)1.86479751
126Genital tract atresia (HP:0001827)1.86432543
127Vaginal atresia (HP:0000148)1.85989035
128Increased CSF lactate (HP:0002490)1.85900323
129Abnormal urine output (HP:0012590)1.85869115
130Renal cortical cysts (HP:0000803)1.85811237
131Optic disc pallor (HP:0000543)1.85338871
132Triphalangeal thumb (HP:0001199)1.84986724
133Hypoplasia of the radius (HP:0002984)1.84646523
134Abnormality of the renal medulla (HP:0100957)1.84251043
135Postaxial hand polydactyly (HP:0001162)1.83976902
136Abnormality of the labia minora (HP:0012880)1.83881042
137Personality changes (HP:0000751)1.82294582
138Capillary hemangiomas (HP:0005306)1.81810752
139Selective tooth agenesis (HP:0001592)1.80037119
140Postaxial foot polydactyly (HP:0001830)1.79419034
141Macrocytic anemia (HP:0001972)1.78915839
142Abnormal albumin level (HP:0012116)1.78815731
143Hypoalbuminemia (HP:0003073)1.78815731
144Preaxial hand polydactyly (HP:0001177)1.78349089
145Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.78339797
146Hip dysplasia (HP:0001385)1.77021151
147Tongue fasciculations (HP:0001308)1.76996160
148Medial flaring of the eyebrow (HP:0010747)1.76985299
149Bone marrow hypocellularity (HP:0005528)1.76851970
150Short thumb (HP:0009778)1.76212017
151Bile duct proliferation (HP:0001408)1.75986626
152Abnormal biliary tract physiology (HP:0012439)1.75986626
153Abnormality of DNA repair (HP:0003254)1.75513384
154Aplasia/hypoplasia of the uterus (HP:0008684)1.75138713
155Decreased activity of mitochondrial respiratory chain (HP:0008972)1.74924015
156Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.74924015
157Acute encephalopathy (HP:0006846)1.74665435
158Abnormal trabecular bone morphology (HP:0100671)1.72522897
159Recurrent bronchitis (HP:0002837)1.72036922
160Congenital sensorineural hearing impairment (HP:0008527)1.71887170
161CNS hypomyelination (HP:0003429)1.71712858
162Failure to thrive in infancy (HP:0001531)1.71509525
163Abnormal mitochondria in muscle tissue (HP:0008316)1.70578582
164Progressive macrocephaly (HP:0004481)1.70551282
165Microretrognathia (HP:0000308)1.70258748
166Retinitis pigmentosa (HP:0000510)1.68526812
167Oligodactyly (HP:0012165)1.68094627
168Pancytopenia (HP:0001876)1.66714708
169Areflexia of lower limbs (HP:0002522)1.66558080
170Photophobia (HP:0000613)1.66511367
171Aplasia/Hypoplasia of the spleen (HP:0010451)1.64454864
172Absent epiphyses (HP:0010577)1.64331279
173Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.64331279
174Short 1st metacarpal (HP:0010034)1.64021359
175Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.64021359
176Pachygyria (HP:0001302)1.63907744
177Abnormality of the renal collecting system (HP:0004742)1.63187783
178Myelodysplasia (HP:0002863)1.61973490
179Delusions (HP:0000746)1.61415975
180Muscle fibrillation (HP:0010546)1.57573145

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK44.66914786
2PDK34.66914786
3BUB14.41670750
4WEE14.31453925
5NEK23.37297229
6BMPR1B3.12356580
7PDK23.11654421
8MAP4K23.05480694
9WNK33.03748915
10INSRR2.96023233
11PNCK2.94262404
12ADRBK22.93996560
13FRK2.90060960
14CDC72.80346422
15TXK2.77624817
16EIF2AK12.70738522
17SRPK12.62460151
18MAP3K42.42778925
19TTK2.38990350
20CCNB12.38485218
21MAP2K72.35148158
22PLK42.29731476
23NME22.27018396
24BCKDK2.22693379
25BRSK22.21249839
26PRKD32.17378563
27TESK12.03771070
28GRK12.03738359
29DYRK32.02471189
30PLK11.94580926
31CHEK21.78998768
32MAPK131.78612092
33STK38L1.71211595
34CAMKK21.65874088
35ACVR1B1.62195991
36CSNK1G21.57320959
37CSNK1G31.56103638
38OXSR11.54690068
39MKNK21.49875080
40MARK11.49193261
41CASK1.48760676
42PLK21.46844764
43BRSK11.43042272
44TRIM281.39280215
45CSNK1A1L1.37557650
46AURKB1.35863479
47CSNK1G11.34375722
48STK161.32145646
49BCR1.30554942
50DAPK21.28870969
51PLK31.26710432
52VRK11.26024358
53EIF2AK31.24310566
54EPHA41.23560200
55STK381.19774132
56LIMK11.15732552
57NEK11.10576798
58STK31.08768483
59AKT31.07606962
60ATR1.07241489
61CDK191.04073894
62CHEK11.03929359
63BRAF1.02792769
64MKNK11.00114755
65PRKCE0.99809338
66CDK70.97962091
67TLK10.97820914
68AURKA0.97435734
69RPS6KA40.97234658
70TAOK30.96038938
71TIE10.95120845
72CAMK10.95110553
73LATS20.93214911
74TSSK60.90738002
75PAK30.89600169
76ICK0.89412897
77CDK40.88097384
78TESK20.87275869
79PTK2B0.81981595
80ARAF0.81645860
81MAP3K80.80462875
82MAP3K110.79989154
83ATM0.72939701
84ADRBK10.72561343
85MAP2K40.72532024
86PAK10.69085325
87LATS10.67236638
88DYRK20.65540569
89CDK20.64302477
90CDK30.64178464
91CSNK2A10.63873656
92STK390.63291489
93MAPK150.60929444
94STK40.60847974
95PBK0.58938176
96NME10.58049487
97NUAK10.57805881
98NTRK20.57719150
99DYRK1A0.57324960
100CAMK2A0.57216155
101EPHA20.57042161
102PRKCQ0.56464483
103CDK80.54809964
104ZAK0.53538929
105PRKACA0.53377763
106STK100.52718185
107FER0.52291730
108PRKAA20.51128558
109CSNK2A20.50982090
110CAMKK10.50814427
111GRK70.50361311
112IRAK30.49536119
113PRKCI0.49168646
114MARK30.49099023
115WNK40.48853742
116PINK10.48600436
117CSNK1A10.47662816
118DYRK1B0.47616961
119CDK10.47325801
120PKN10.45345414
121PHKG20.45028562
122PHKG10.45028562
123WNK10.44796134
124CSNK1D0.43518357
125MAPKAPK50.43411661
126PIK3CG0.43389261
127TNIK0.43014585
128CAMK1G0.43006426
129EIF2AK20.42797355
130PIM10.42041506
131PRKCZ0.41969385
132SIK20.40059754
133MAP3K70.39163007
134CSNK1E0.39050722
135PASK0.38372653
136LMTK20.37150286
137MAP2K60.37045664
138MUSK0.36506733
139PRKCA0.35757319
140CDK120.35585577
141MELK0.35459513
142IKBKB0.34015795
143ABL20.33493514
144TYRO30.31926469
145RPS6KA50.31677868
146MINK10.31589955
147CAMK40.31401359
148SYK0.31303965
149OBSCN0.31132245
150MAP3K50.31023783
151PRKCH0.30543358
152GRK60.30395437
153PDK10.29105217
154TGFBR10.28914762
155STK110.28080369
156PRKCG0.26909410
157PIM20.26745686
158CLK10.25303273
159NLK0.24926422
160PRKDC0.23469347
161CDK11A0.20639855
162CDK150.18357049
163ALK0.17994862
164PRKAA10.17402426
165AKT20.16175307
166CDK180.14762769
167CDK60.14576969
168MAP3K90.13795850
169GSK3B0.13344163

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.03411212
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.14739638
3RNA polymerase_Homo sapiens_hsa030204.04445986
4DNA replication_Homo sapiens_hsa030303.79371570
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.49189148
6Homologous recombination_Homo sapiens_hsa034403.47230762
7RNA transport_Homo sapiens_hsa030133.43223122
8Basal transcription factors_Homo sapiens_hsa030223.26994937
9Proteasome_Homo sapiens_hsa030502.98042280
10Spliceosome_Homo sapiens_hsa030402.97399454
11Pyrimidine metabolism_Homo sapiens_hsa002402.95505249
12Mismatch repair_Homo sapiens_hsa034302.86288853
13Phototransduction_Homo sapiens_hsa047442.85254329
14Fanconi anemia pathway_Homo sapiens_hsa034602.81900406
15Cell cycle_Homo sapiens_hsa041102.72696749
16Ribosome_Homo sapiens_hsa030102.54704027
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.51797292
18Nucleotide excision repair_Homo sapiens_hsa034202.35342329
19Butanoate metabolism_Homo sapiens_hsa006502.34120864
20Base excision repair_Homo sapiens_hsa034102.33885928
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.29054499
22Nicotine addiction_Homo sapiens_hsa050332.15627903
23Purine metabolism_Homo sapiens_hsa002302.09942703
24Pentose phosphate pathway_Homo sapiens_hsa000301.92420514
25mRNA surveillance pathway_Homo sapiens_hsa030151.92072695
26Olfactory transduction_Homo sapiens_hsa047401.89854596
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88987971
28Nitrogen metabolism_Homo sapiens_hsa009101.86976155
29RNA degradation_Homo sapiens_hsa030181.81194117
30Oocyte meiosis_Homo sapiens_hsa041141.71273080
31Taste transduction_Homo sapiens_hsa047421.56261484
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44826658
33Huntingtons disease_Homo sapiens_hsa050161.44169750
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.37305036
35p53 signaling pathway_Homo sapiens_hsa041151.34131009
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33906418
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33881927
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.30365126
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28442832
40Linoleic acid metabolism_Homo sapiens_hsa005911.24518410
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22889780
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.22481640
43Peroxisome_Homo sapiens_hsa041461.22387343
44One carbon pool by folate_Homo sapiens_hsa006701.19833049
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18294765
46Caffeine metabolism_Homo sapiens_hsa002321.15927479
47Tryptophan metabolism_Homo sapiens_hsa003801.14888466
48Steroid biosynthesis_Homo sapiens_hsa001001.13348111
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13285984
50Morphine addiction_Homo sapiens_hsa050321.11514253
51Non-homologous end-joining_Homo sapiens_hsa034501.09594364
52Glycerophospholipid metabolism_Homo sapiens_hsa005641.08397824
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07939744
54Chemical carcinogenesis_Homo sapiens_hsa052041.05977653
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05021426
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03332698
57Epstein-Barr virus infection_Homo sapiens_hsa051691.03324810
58Steroid hormone biosynthesis_Homo sapiens_hsa001401.02325815
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02103894
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01273136
61GABAergic synapse_Homo sapiens_hsa047271.00935697
62ABC transporters_Homo sapiens_hsa020100.98921293
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98011862
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96906300
65Glutathione metabolism_Homo sapiens_hsa004800.95883304
66Selenocompound metabolism_Homo sapiens_hsa004500.92743873
67beta-Alanine metabolism_Homo sapiens_hsa004100.90633885
68Collecting duct acid secretion_Homo sapiens_hsa049660.89328579
69Fructose and mannose metabolism_Homo sapiens_hsa000510.89294545
70Biosynthesis of amino acids_Homo sapiens_hsa012300.87880892
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86840546
72Insulin secretion_Homo sapiens_hsa049110.80952351
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80307350
74Folate biosynthesis_Homo sapiens_hsa007900.79374647
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78976604
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78629815
77Vitamin digestion and absorption_Homo sapiens_hsa049770.74028473
78Regulation of autophagy_Homo sapiens_hsa041400.73578988
79Sulfur relay system_Homo sapiens_hsa041220.73377322
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.71411420
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69768809
82Fatty acid degradation_Homo sapiens_hsa000710.69673025
83Glutamatergic synapse_Homo sapiens_hsa047240.69342493
84Circadian entrainment_Homo sapiens_hsa047130.68004591
85Arachidonic acid metabolism_Homo sapiens_hsa005900.66426846
86Antigen processing and presentation_Homo sapiens_hsa046120.66127839
87Carbon metabolism_Homo sapiens_hsa012000.65407102
88Type I diabetes mellitus_Homo sapiens_hsa049400.62642342
89Basal cell carcinoma_Homo sapiens_hsa052170.61120863
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58955341
91Serotonergic synapse_Homo sapiens_hsa047260.58663862
92Herpes simplex infection_Homo sapiens_hsa051680.56485706
93Propanoate metabolism_Homo sapiens_hsa006400.56326995
94Metabolic pathways_Homo sapiens_hsa011000.55828813
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55617317
96Synaptic vesicle cycle_Homo sapiens_hsa047210.54678856
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53428369
98Salivary secretion_Homo sapiens_hsa049700.51408272
99Ether lipid metabolism_Homo sapiens_hsa005650.49676077
100Primary immunodeficiency_Homo sapiens_hsa053400.48574474
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47202035
102Sulfur metabolism_Homo sapiens_hsa009200.47195307
103Ovarian steroidogenesis_Homo sapiens_hsa049130.46894968
104Cocaine addiction_Homo sapiens_hsa050300.46507677
105Mineral absorption_Homo sapiens_hsa049780.46491967
106Calcium signaling pathway_Homo sapiens_hsa040200.46213633
107Systemic lupus erythematosus_Homo sapiens_hsa053220.46131622
108Glucagon signaling pathway_Homo sapiens_hsa049220.44871914
109Renin-angiotensin system_Homo sapiens_hsa046140.44122169
110Glycerolipid metabolism_Homo sapiens_hsa005610.42611955
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41659823
112Pyruvate metabolism_Homo sapiens_hsa006200.41079319
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.40487939
114Fatty acid metabolism_Homo sapiens_hsa012120.40295463
115Viral carcinogenesis_Homo sapiens_hsa052030.40161700
116Protein export_Homo sapiens_hsa030600.38681554
117Autoimmune thyroid disease_Homo sapiens_hsa053200.37444211
118Graft-versus-host disease_Homo sapiens_hsa053320.36506819
119Oxidative phosphorylation_Homo sapiens_hsa001900.35290429
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34554474
121Parkinsons disease_Homo sapiens_hsa050120.34514492
122Dopaminergic synapse_Homo sapiens_hsa047280.32565363
123Fatty acid biosynthesis_Homo sapiens_hsa000610.31529977
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28253913
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27083278
126HTLV-I infection_Homo sapiens_hsa051660.25410906
127Cardiac muscle contraction_Homo sapiens_hsa042600.23672361
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19557829
129Inositol phosphate metabolism_Homo sapiens_hsa005620.17498984
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13983572
131Sphingolipid metabolism_Homo sapiens_hsa006000.12087171
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.11482462
133Retinol metabolism_Homo sapiens_hsa008300.10325449
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.08833304
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.08797186
136Hippo signaling pathway_Homo sapiens_hsa043900.08081200
137Arginine and proline metabolism_Homo sapiens_hsa003300.07760020
138Dorso-ventral axis formation_Homo sapiens_hsa043200.07382822
139Fat digestion and absorption_Homo sapiens_hsa049750.07053131
140Circadian rhythm_Homo sapiens_hsa047100.05709780
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.04263463
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.04248493
143Hedgehog signaling pathway_Homo sapiens_hsa043400.03506334
144Small cell lung cancer_Homo sapiens_hsa052220.02724192
145Prostate cancer_Homo sapiens_hsa052150.01783641
146Alcoholism_Homo sapiens_hsa050340.01517013
147TGF-beta signaling pathway_Homo sapiens_hsa043500.00921207
148Amphetamine addiction_Homo sapiens_hsa05031-0.0380478
149Tight junction_Homo sapiens_hsa04530-0.0248115
150MicroRNAs in cancer_Homo sapiens_hsa05206-0.0228661
151AMPK signaling pathway_Homo sapiens_hsa04152-0.0205297
152Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0117037
153Alzheimers disease_Homo sapiens_hsa05010-0.0094740

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