FANCE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group E. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.19190322
2mitotic chromosome condensation (GO:0007076)5.17044415
3DNA unwinding involved in DNA replication (GO:0006268)4.73835653
4DNA replication checkpoint (GO:0000076)4.52433785
5nuclear pore complex assembly (GO:0051292)4.19072400
6mitotic metaphase plate congression (GO:0007080)4.09993918
7ribosomal small subunit assembly (GO:0000028)4.07772817
8nuclear pore organization (GO:0006999)4.02897361
9negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.94590932
10formation of translation preinitiation complex (GO:0001731)3.90231793
11mitotic sister chromatid segregation (GO:0000070)3.87215488
12ribosomal small subunit biogenesis (GO:0042274)3.81426618
13DNA integration (GO:0015074)3.79153229
14negative regulation of DNA-templated transcription, elongation (GO:0032785)3.78497816
15viral transcription (GO:0019083)3.75350003
16regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.72615303
17protein localization to chromosome, centromeric region (GO:0071459)3.72022859
18sister chromatid segregation (GO:0000819)3.65753932
19kinetochore assembly (GO:0051382)3.62279624
20heterochromatin organization (GO:0070828)3.61199405
21translational termination (GO:0006415)3.59006178
22chromatin remodeling at centromere (GO:0031055)3.56895825
23protein localization to kinetochore (GO:0034501)3.56656426
24adenosine metabolic process (GO:0046085)3.53541741
25tRNA methylation (GO:0030488)3.52233332
26regulation of nuclear cell cycle DNA replication (GO:0033262)3.48411328
27telomere maintenance via semi-conservative replication (GO:0032201)3.46668557
28maturation of SSU-rRNA (GO:0030490)3.44759421
29regulation of translational fidelity (GO:0006450)3.44577511
30synapsis (GO:0007129)3.42698993
31mitotic sister chromatid cohesion (GO:0007064)3.42086853
32deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.42024261
33pore complex assembly (GO:0046931)3.41433719
34tRNA modification (GO:0006400)3.38273290
35ribosome biogenesis (GO:0042254)3.35700006
36metaphase plate congression (GO:0051310)3.34027825
37macromolecular complex disassembly (GO:0032984)3.30205910
38mitotic nuclear envelope disassembly (GO:0007077)3.26564419
39chromatin assembly (GO:0031497)3.25119253
40telomere maintenance via telomere lengthening (GO:0010833)3.20547403
41base-excision repair, AP site formation (GO:0006285)3.20367935
42negative regulation of telomere maintenance (GO:0032205)3.19665716
43DNA replication initiation (GO:0006270)3.18091806
44ribosomal large subunit biogenesis (GO:0042273)3.17993820
45DNA strand elongation involved in DNA replication (GO:0006271)3.16727878
46regulation of double-strand break repair via homologous recombination (GO:0010569)3.16460917
47nucleobase biosynthetic process (GO:0046112)3.15435361
48DNA replication-dependent nucleosome assembly (GO:0006335)3.15407627
49DNA replication-dependent nucleosome organization (GO:0034723)3.15407627
50mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.15219018
51protein K6-linked ubiquitination (GO:0085020)3.14801598
52DNA strand renaturation (GO:0000733)3.14097989
53somatic hypermutation of immunoglobulin genes (GO:0016446)3.13120144
54somatic diversification of immune receptors via somatic mutation (GO:0002566)3.13120144
55DNA strand elongation (GO:0022616)3.12614316
56mitochondrial RNA metabolic process (GO:0000959)3.10396917
57chromatin assembly or disassembly (GO:0006333)3.07719630
58maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.06997317
59chromosome segregation (GO:0007059)3.06668388
60chromosome organization involved in meiosis (GO:0070192)3.05112275
61membrane disassembly (GO:0030397)3.04952329
62nuclear envelope disassembly (GO:0051081)3.04952329
63atrioventricular valve morphogenesis (GO:0003181)3.04700121
64transcription-coupled nucleotide-excision repair (GO:0006283)3.03220526
65IMP biosynthetic process (GO:0006188)3.02980945
66chromosome condensation (GO:0030261)3.02511499
67nuclear-transcribed mRNA catabolic process (GO:0000956)3.02225546
68kinetochore organization (GO:0051383)3.00052386
69sister chromatid cohesion (GO:0007062)2.99484414
70cellular component biogenesis (GO:0044085)2.98920470
71post-embryonic morphogenesis (GO:0009886)2.97572772
72DNA replication-independent nucleosome organization (GO:0034724)2.96546549
73DNA replication-independent nucleosome assembly (GO:0006336)2.96546549
74translation (GO:0006412)2.93197253
75DNA damage response, signal transduction resulting in transcription (GO:0042772)2.90751516
76regulation of mitotic spindle checkpoint (GO:1903504)2.90063516
77regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.90063516
78mRNA catabolic process (GO:0006402)2.89765517
79viral mRNA export from host cell nucleus (GO:0046784)2.89152535
80histone exchange (GO:0043486)2.88726055
81regulation of spindle checkpoint (GO:0090231)2.88656419
82translational elongation (GO:0006414)2.85734260
83negative regulation of chromosome segregation (GO:0051985)2.85288460
84telomere maintenance via recombination (GO:0000722)2.85109961
85DNA topological change (GO:0006265)2.83447521
86SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.83299103
87ribonucleoprotein complex biogenesis (GO:0022613)2.81401564
88RNA catabolic process (GO:0006401)2.80670292
89telomere organization (GO:0032200)2.79889816
90regulation of telomere maintenance via telomerase (GO:0032210)2.79863787
91regulation of helicase activity (GO:0051095)2.79557024
92piRNA metabolic process (GO:0034587)2.79314374
93nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.79030198
94spliceosomal snRNP assembly (GO:0000387)2.78775593
95pseudouridine synthesis (GO:0001522)2.78348660
96establishment of chromosome localization (GO:0051303)2.77702413
97telomere maintenance (GO:0000723)2.77547783
98regulation of hippo signaling (GO:0035330)2.77295714
99mitotic spindle checkpoint (GO:0071174)2.76706358
100regulation of sister chromatid cohesion (GO:0007063)2.75879567
101mismatch repair (GO:0006298)2.74719350
102DNA biosynthetic process (GO:0071897)2.74690660
103rRNA processing (GO:0006364)2.74378317
104proteasome assembly (GO:0043248)2.73953802
105translesion synthesis (GO:0019985)2.73903196
106epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.71777118
107cotranslational protein targeting to membrane (GO:0006613)2.71646751
108DNA packaging (GO:0006323)2.71224758
109protein targeting to ER (GO:0045047)2.70905180
110transcription from mitochondrial promoter (GO:0006390)2.70393809
111rRNA metabolic process (GO:0016072)2.69380565
112face development (GO:0060324)2.69050073
113epithelial cell fate commitment (GO:0072148)2.68592211
114DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.67403037
115amino sugar catabolic process (GO:0046348)2.67313162
116DNA ligation (GO:0006266)2.67259250
117cell proliferation in forebrain (GO:0021846)2.67179009
118single strand break repair (GO:0000012)2.65459247
119nucleotide-excision repair, DNA gap filling (GO:0006297)2.64884119
120cellular protein complex disassembly (GO:0043624)2.64879035
121meiotic chromosome segregation (GO:0045132)2.64363979
122tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.62989398
123RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.62989398
124response to folic acid (GO:0051593)2.62199557
125replication fork processing (GO:0031297)2.62084574
126telomere maintenance via telomerase (GO:0007004)2.61858342
127tRNA processing (GO:0008033)2.61684906
128rRNA modification (GO:0000154)2.59984723
129mesenchymal to epithelial transition (GO:0060231)2.59467517
130viral life cycle (GO:0019058)2.58080350
131translational initiation (GO:0006413)2.57872494
132establishment of protein localization to endoplasmic reticulum (GO:0072599)2.55715626
133regulation of DNA damage checkpoint (GO:2000001)2.54834011
134termination of RNA polymerase III transcription (GO:0006386)2.54191210
135transcription elongation from RNA polymerase III promoter (GO:0006385)2.54191210
136regulation of somitogenesis (GO:0014807)2.53549963
137negative regulation of DNA-dependent DNA replication (GO:2000104)2.53240480
138regulation of gene silencing by RNA (GO:0060966)2.53213448
139regulation of posttranscriptional gene silencing (GO:0060147)2.53213448
140regulation of gene silencing by miRNA (GO:0060964)2.53213448
141termination of RNA polymerase I transcription (GO:0006363)2.53121703
142paraxial mesoderm development (GO:0048339)2.52056906
143DNA damage response, detection of DNA damage (GO:0042769)2.51828359
144mitotic recombination (GO:0006312)2.51413771
145pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.50898554
146ncRNA processing (GO:0034470)2.50442747
147protein localization to endoplasmic reticulum (GO:0070972)2.49238009
148regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.47827439
149intra-S DNA damage checkpoint (GO:0031573)2.47766766
150RNA methylation (GO:0001510)2.47075789
151pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.45226537
152protein complex disassembly (GO:0043241)2.44912802
153regulation of mammary gland epithelial cell proliferation (GO:0033599)2.44293019
154embryonic camera-type eye development (GO:0031076)2.43348427
155transcription elongation from RNA polymerase I promoter (GO:0006362)2.42550726
156platelet dense granule organization (GO:0060155)2.42451337
157CENP-A containing nucleosome assembly (GO:0034080)2.40550820
158lymphoid progenitor cell differentiation (GO:0002320)2.40511490
159spinal cord association neuron differentiation (GO:0021527)2.37223661
160base-excision repair (GO:0006284)2.36689485
161negative regulation of transcription by competitive promoter binding (GO:0010944)2.36168615
162RNA modification (GO:0009451)2.35600577
163DNA synthesis involved in DNA repair (GO:0000731)2.35454360
164regulation of development, heterochronic (GO:0040034)2.34904650

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.90634954
2TP63_19390658_ChIP-ChIP_HaCaT_Human4.11595635
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.88861358
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.75565067
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.09995524
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.02544932
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.98445646
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.95117465
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.93019485
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80965615
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.73772430
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.73772430
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.73772430
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63364015
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.41676700
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30216813
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26715161
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.23916072
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.22482885
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.15528595
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.14162651
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.11777304
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98923326
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.93995690
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88193053
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87957396
27YY1_21170310_ChIP-Seq_MESCs_Mouse1.84014691
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83377253
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.79682943
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79424623
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.79159611
32* TTF2_22483619_ChIP-Seq_HELA_Human1.77395151
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76138752
34* XRN2_22483619_ChIP-Seq_HELA_Human1.74818267
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.67257412
36KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.65240897
37SCL_19346495_ChIP-Seq_HPC-7_Human1.64320840
38DCP1A_22483619_ChIP-Seq_HELA_Human1.61943377
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.61363293
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61002303
41FOXP3_21729870_ChIP-Seq_TREG_Human1.59500180
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.55921150
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54587940
44AR_21909140_ChIP-Seq_LNCAP_Human1.54102998
45* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53939241
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52781726
47KDM5A_27292631_Chip-Seq_BREAST_Human1.51675083
48SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.49346293
49MYC_18940864_ChIP-ChIP_HL60_Human1.46407661
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45897964
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42595170
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42520155
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42153645
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42044369
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41459489
56VDR_21846776_ChIP-Seq_THP-1_Human1.41214801
57IRF1_19129219_ChIP-ChIP_H3396_Human1.38711619
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34959064
59E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.34362794
60ELK1_19687146_ChIP-ChIP_HELA_Human1.32855819
61VDR_23849224_ChIP-Seq_CD4+_Human1.30227672
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27956753
63* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26813776
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26343621
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.24790149
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23140931
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19748493
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19340916
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17692051
70CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17544230
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13160809
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12541838
73CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11931828
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11825901
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11455175
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.10747521
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10362959
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09062375
79ZNF263_19887448_ChIP-Seq_K562_Human1.07777612
80EGR1_19374776_ChIP-ChIP_THP-1_Human1.07403335
81SOX2_16153702_ChIP-ChIP_HESCs_Human1.07294087
82TP53_20018659_ChIP-ChIP_R1E_Mouse1.06647871
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06560716
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05917895
85CIITA_25753668_ChIP-Seq_RAJI_Human1.04153637
86* YY1_22570637_ChIP-Seq_MALME-3M_Human1.03829843
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00879833
88RNF2_27304074_Chip-Seq_NSC_Mouse0.99068048
89ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98944934
90ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98346952
91STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96706863
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96063860
93NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94985916
94IGF1R_20145208_ChIP-Seq_DFB_Human0.93374385
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92732549
96STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91948516
97MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91761462
98POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91715448
99RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91405050
100FOXP1_21924763_ChIP-Seq_HESCs_Human0.91228956
101YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90559295
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90261538
103TET1_21451524_ChIP-Seq_MESCs_Mouse0.88605752
104SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88268973
105LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87470255
106GABP_19822575_ChIP-Seq_HepG2_Human0.86727786
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86188714
108NANOG_16153702_ChIP-ChIP_HESCs_Human0.85257932
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84686305
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84533907
111TFEB_21752829_ChIP-Seq_HELA_Human0.84281838
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.83512610
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82803141
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82585266
115PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82496433
116SPI1_23547873_ChIP-Seq_NB4_Human0.82156563
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82016582
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81292064
119ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81251297
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81241953
121TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80908648
122SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80615016
123KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79411459
124TCF3_18692474_ChIP-Seq_MESCs_Mouse0.79264555
125PADI4_21655091_ChIP-ChIP_MCF-7_Human0.78989296
126NCOR1_26117541_ChIP-Seq_K562_Human0.78260254
127NFE2_27457419_Chip-Seq_LIVER_Mouse0.78003795
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.76398561
129CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.75894725
130GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.75835223
131KAP1_27257070_Chip-Seq_ESCs_Mouse0.75771194
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.75354234
133STAT1_20625510_ChIP-Seq_HELA_Human0.75130221
134MYC_22102868_ChIP-Seq_BL_Human0.74589252
135FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73403341
136E2F1_20622854_ChIP-Seq_HELA_Human0.70243872

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.55356550
2MP0006292_abnormal_olfactory_placode3.88454991
3MP0002102_abnormal_ear_morphology3.83131237
4MP0003136_yellow_coat_color3.06545449
5MP0003111_abnormal_nucleus_morphology3.00141956
6MP0008058_abnormal_DNA_repair2.96684475
7MP0008057_abnormal_DNA_replication2.75190275
8MP0003693_abnormal_embryo_hatching2.72963336
9MP0002249_abnormal_larynx_morphology2.69007205
10MP0003941_abnormal_skin_development2.50915927
11MP0010094_abnormal_chromosome_stability2.47312785
12MP0010030_abnormal_orbit_morphology2.43142066
13MP0004381_abnormal_hair_follicle2.41924572
14MP0000049_abnormal_middle_ear2.11805737
15MP0001188_hyperpigmentation2.08697657
16MP0002132_abnormal_respiratory_system2.05787216
17MP0002396_abnormal_hematopoietic_system2.04849408
18MP0001730_embryonic_growth_arrest2.01955197
19MP0003077_abnormal_cell_cycle1.96642175
20MP0003786_premature_aging1.93431410
21MP0008995_early_reproductive_senescence1.83266114
22MP0004185_abnormal_adipocyte_glucose1.75472751
23MP0001672_abnormal_embryogenesis/_devel1.73347148
24MP0005380_embryogenesis_phenotype1.73347148
25MP0005174_abnormal_tail_pigmentation1.70602772
26MP0008932_abnormal_embryonic_tissue1.69340135
27MP0000490_abnormal_crypts_of1.67977601
28MP0003011_delayed_dark_adaptation1.67817146
29MP0005076_abnormal_cell_differentiation1.67095407
30MP0004957_abnormal_blastocyst_morpholog1.53975898
31MP0001697_abnormal_embryo_size1.52952212
32MP0003938_abnormal_ear_development1.52407672
33MP0003984_embryonic_growth_retardation1.51823047
34MP0000537_abnormal_urethra_morphology1.49794087
35MP0008877_abnormal_DNA_methylation1.47469952
36MP0005075_abnormal_melanosome_morpholog1.46962211
37MP0002088_abnormal_embryonic_growth/wei1.45966687
38MP0001929_abnormal_gametogenesis1.45927897
39MP0002080_prenatal_lethality1.44911727
40MP0004233_abnormal_muscle_weight1.44583789
41MP0008007_abnormal_cellular_replicative1.44505471
42MP0002084_abnormal_developmental_patter1.43375644
43MP0008260_abnormal_autophagy1.41847675
44MP0009333_abnormal_splenocyte_physiolog1.39675538
45MP0001293_anophthalmia1.38865795
46MP0005257_abnormal_intraocular_pressure1.38220813
47MP0005423_abnormal_somatic_nervous1.33774017
48MP0004133_heterotaxia1.30942370
49MP0010307_abnormal_tumor_latency1.28888716
50MP0001986_abnormal_taste_sensitivity1.28633600
51MP0001145_abnormal_male_reproductive1.28133989
52MP0003646_muscle_fatigue1.27843009
53MP0006072_abnormal_retinal_apoptosis1.27597113
54MP0002638_abnormal_pupillary_reflex1.25225950
55MP0003567_abnormal_fetal_cardiomyocyte1.24051302
56MP0009672_abnormal_birth_weight1.22935256
57MP0003937_abnormal_limbs/digits/tail_de1.22864737
58MP0003705_abnormal_hypodermis_morpholog1.21873532
59MP0002277_abnormal_respiratory_mucosa1.21620154
60MP0001286_abnormal_eye_development1.20523448
61MP0001661_extended_life_span1.19234766
62MP0000653_abnormal_sex_gland1.18013573
63MP0004147_increased_porphyrin_level1.16845871
64MP0000015_abnormal_ear_pigmentation1.15021769
65MP0003315_abnormal_perineum_morphology1.14602595
66MP0003718_maternal_effect1.14295012
67MP0001346_abnormal_lacrimal_gland1.12497781
68MP0000762_abnormal_tongue_morphology1.12408286
69MP0000358_abnormal_cell_content/1.10529532
70MP0005391_vision/eye_phenotype1.07902916
71MP0002751_abnormal_autonomic_nervous1.07395095
72MP0003943_abnormal_hepatobiliary_system1.07386186
73MP0002938_white_spotting1.06409472
74MP0004197_abnormal_fetal_growth/weight/1.05458992
75MP0006035_abnormal_mitochondrial_morpho1.04243196
76MP0000579_abnormal_nail_morphology1.03640574
77MP0002234_abnormal_pharynx_morphology1.03455764
78MP0000383_abnormal_hair_follicle1.00607478
79MP0002160_abnormal_reproductive_system0.98677474
80MP0002098_abnormal_vibrissa_morphology0.98495450
81MP0002086_abnormal_extraembryonic_tissu0.98447486
82MP0002796_impaired_skin_barrier0.96740016
83MP0003755_abnormal_palate_morphology0.96060892
84MP0005253_abnormal_eye_physiology0.94913927
85MP0005451_abnormal_body_composition0.94621413
86MP0000470_abnormal_stomach_morphology0.94321760
87MP0003890_abnormal_embryonic-extraembry0.94041693
88MP0009379_abnormal_foot_pigmentation0.93805509
89MP0002009_preneoplasia0.93180171
90MP0005508_abnormal_skeleton_morphology0.91923816
91MP0002111_abnormal_tail_morphology0.91356561
92MP0002116_abnormal_craniofacial_bone0.91224728
93MP0000026_abnormal_inner_ear0.90656139
94MP0000647_abnormal_sebaceous_gland0.90027230
95MP0002092_abnormal_eye_morphology0.89607892
96MP0009250_abnormal_appendicular_skeleto0.89286066
97MP0000372_irregular_coat_pigmentation0.88675331
98MP0003699_abnormal_female_reproductive0.88595703
99MP0000678_abnormal_parathyroid_gland0.88448914
100MP0003123_paternal_imprinting0.87874642
101MP0003698_abnormal_male_reproductive0.87741183
102MP0002697_abnormal_eye_size0.86770811
103MP0000465_gastrointestinal_hemorrhage0.86682659
104MP0003959_abnormal_lean_body0.86575475
105MP0000613_abnormal_salivary_gland0.86315550
106MP0004134_abnormal_chest_morphology0.86115379
107MP0000428_abnormal_craniofacial_morphol0.85660083
108MP0003950_abnormal_plasma_membrane0.85310489
109MP0005379_endocrine/exocrine_gland_phen0.85045239
110MP0008789_abnormal_olfactory_epithelium0.84770747
111MP0000858_altered_metastatic_potential0.82318053
112MP0000313_abnormal_cell_death0.81450158
113MP0005503_abnormal_tendon_morphology0.79028138
114MP0003724_increased_susceptibility_to0.78896987
115MP0003935_abnormal_craniofacial_develop0.78328208
116MP0005389_reproductive_system_phenotype0.78135500
117MP0002233_abnormal_nose_morphology0.77696543
118MP0009278_abnormal_bone_marrow0.77187672
119MP0002019_abnormal_tumor_incidence0.75649856
120MP0000703_abnormal_thymus_morphology0.75524817
121MP0000685_abnormal_immune_system0.74651963
122MP0002095_abnormal_skin_pigmentation0.74040426
123MP0003119_abnormal_digestive_system0.73965114
124MP0005501_abnormal_skin_physiology0.73510641
125MP0006036_abnormal_mitochondrial_physio0.73197691
126MP0002085_abnormal_embryonic_tissue0.73128291
127MP0003763_abnormal_thymus_physiology0.73068811
128MP0005397_hematopoietic_system_phenotyp0.72921569
129MP0001545_abnormal_hematopoietic_system0.72921569
130MP0000749_muscle_degeneration0.72322870
131MP0002161_abnormal_fertility/fecundity0.71643901
132MP0001216_abnormal_epidermal_layer0.71312406
133MP0002269_muscular_atrophy0.71301352
134MP0001119_abnormal_female_reproductive0.70844206
135MP0000350_abnormal_cell_proliferation0.69991965
136MP0002210_abnormal_sex_determination0.69889913
137MP0000432_abnormal_head_morphology0.69621041
138MP0005551_abnormal_eye_electrophysiolog0.68624311
139MP0002932_abnormal_joint_morphology0.67935881
140MP0002163_abnormal_gland_morphology0.67559287
141MP0002722_abnormal_immune_system0.65878744
142MP0002089_abnormal_postnatal_growth/wei0.63314146
143MP0002405_respiratory_system_inflammati0.63249493
144MP0004808_abnormal_hematopoietic_stem0.63065942
145MP0005390_skeleton_phenotype0.62016512
146MP0002398_abnormal_bone_marrow0.61685400
147MP0000163_abnormal_cartilage_morphology0.60781867
148MP0000377_abnormal_hair_follicle0.60485420

Predicted human phenotypes

RankGene SetZ-score
1* Chromosomal breakage induced by crosslinking agents (HP:0003221)5.43854316
2* Chromsome breakage (HP:0040012)4.79270958
3* Reticulocytopenia (HP:0001896)4.11353168
4Absent rod-and cone-mediated responses on ERG (HP:0007688)3.96759705
5* Duplication of thumb phalanx (HP:0009942)3.65016770
6Partial duplication of thumb phalanx (HP:0009944)3.60514139
7Upper limb muscle weakness (HP:0003484)3.47693751
8Concave nail (HP:0001598)3.44237977
9Abnormal number of erythroid precursors (HP:0012131)3.13003265
10Partial duplication of the phalanx of hand (HP:0009999)3.11317586
11Abnormality of cells of the erythroid lineage (HP:0012130)3.10841379
12* Duplicated collecting system (HP:0000081)3.10559323
13Congenital stationary night blindness (HP:0007642)3.04113553
14Progressive muscle weakness (HP:0003323)2.97305420
15* Abnormality of the preputium (HP:0100587)2.93830105
16Breast hypoplasia (HP:0003187)2.91181149
17* Aplasia/Hypoplasia of the uvula (HP:0010293)2.83825860
18* Abnormality of the ileum (HP:0001549)2.80816731
19* Meckel diverticulum (HP:0002245)2.80691119
20* Absent radius (HP:0003974)2.77278603
21Septo-optic dysplasia (HP:0100842)2.76353786
22Abnormal rod and cone electroretinograms (HP:0008323)2.73802474
23* Aplasia involving forearm bones (HP:0009822)2.71609238
24* Absent forearm bone (HP:0003953)2.71609238
25* Abnormality of the renal collecting system (HP:0004742)2.70861621
26* Triphalangeal thumb (HP:0001199)2.68171329
27Aplasia cutis congenita (HP:0001057)2.67231874
28Aplastic anemia (HP:0001915)2.65051698
29* Pallor (HP:0000980)2.56401946
3011 pairs of ribs (HP:0000878)2.49082164
31Poikiloderma (HP:0001029)2.46862315
32Increased nuchal translucency (HP:0010880)2.41038835
33Pendular nystagmus (HP:0012043)2.39282146
34* Ureteral duplication (HP:0000073)2.36755159
35Sex reversal (HP:0012245)2.36147435
36Abnormal sex determination (HP:0012244)2.36147435
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35050223
38Abnormality of alanine metabolism (HP:0010916)2.35050223
39Hyperalaninemia (HP:0003348)2.35050223
40Bony spicule pigmentary retinopathy (HP:0007737)2.32670917
41Patellar aplasia (HP:0006443)2.32651340
42* Absent thumb (HP:0009777)2.31325293
43Hypoplasia of the pons (HP:0012110)2.30326635
44Abnormal number of incisors (HP:0011064)2.28957267
45Lipid accumulation in hepatocytes (HP:0006561)2.27869922
46* Abnormality of reticulocytes (HP:0004312)2.27331559
47* Abnormality of DNA repair (HP:0003254)2.24949160
48Abnormality of cochlea (HP:0000375)2.23733213
49* Abnormality of chromosome stability (HP:0003220)2.23476717
50* Clubbing of toes (HP:0100760)2.23195591
51Increased corneal curvature (HP:0100692)2.21315811
52Keratoconus (HP:0000563)2.21315811
53Abnormality of the dental pulp (HP:0006479)2.16573456
54Nasolacrimal duct obstruction (HP:0000579)2.16104472
55* Bone marrow hypocellularity (HP:0005528)2.15862502
56Overfolded helix (HP:0000396)2.15183516
57Aplasia/Hypoplasia of the patella (HP:0006498)2.15133821
58Type I transferrin isoform profile (HP:0003642)2.15038652
59Abnormality of the pons (HP:0007361)2.14079315
60Entropion (HP:0000621)2.14005423
61Attenuation of retinal blood vessels (HP:0007843)2.11565456
62High anterior hairline (HP:0009890)2.10894927
63* Horseshoe kidney (HP:0000085)2.09877022
64Neonatal short-limb short stature (HP:0008921)2.09578391
65Conical tooth (HP:0000698)2.09504472
66Septate vagina (HP:0001153)2.09375363
67Sparse scalp hair (HP:0002209)2.06155820
68* Sloping forehead (HP:0000340)2.05688229
69Abnormality of the antihelix (HP:0009738)2.04389572
70Hypoplasia of the radius (HP:0002984)2.03972967
71Colon cancer (HP:0003003)2.02342904
72Asplenia (HP:0001746)2.01759582
73Trismus (HP:0000211)2.00705916
74Bilateral sensorineural hearing impairment (HP:0008619)2.00416581
75Ragged-red muscle fibers (HP:0003200)1.99717276
76Decreased central vision (HP:0007663)1.98919346
77Supernumerary spleens (HP:0009799)1.98509333
78Increased IgE level (HP:0003212)1.96900823
79Broad distal phalanx of finger (HP:0009836)1.96514149
80Aplasia/Hypoplasia of the earlobes (HP:0009906)1.96446827
81Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95460965
82Macrocytic anemia (HP:0001972)1.95451107
83Premature ovarian failure (HP:0008209)1.95263939
84Nephroblastoma (Wilms tumor) (HP:0002667)1.94330611
85* Small intestinal stenosis (HP:0012848)1.93495695
86* Duodenal stenosis (HP:0100867)1.93495695
87Cleft eyelid (HP:0000625)1.91702307
88Xerostomia (HP:0000217)1.89544290
89* Short thumb (HP:0009778)1.88656802
90Abnormally folded helix (HP:0008544)1.88202235
91Reduced antithrombin III activity (HP:0001976)1.87634506
92Embryonal renal neoplasm (HP:0011794)1.86929735
93Thrombocytosis (HP:0001894)1.86137611
94True hermaphroditism (HP:0010459)1.85745019
95Abnormality of the lacrimal duct (HP:0011481)1.85552932
96Abnormal mitochondria in muscle tissue (HP:0008316)1.84901998
97Missing ribs (HP:0000921)1.84576973
98Microvesicular hepatic steatosis (HP:0001414)1.84331303
99* Renal agenesis (HP:0000104)1.83920506
100Sclerocornea (HP:0000647)1.83912461
101Aplasia/Hypoplasia of the spleen (HP:0010451)1.82888187
102Rough bone trabeculation (HP:0100670)1.82095146
103Oral leukoplakia (HP:0002745)1.81659033
104Squamous cell carcinoma (HP:0002860)1.81514047
105Increased hepatocellular lipid droplets (HP:0006565)1.81231220
106* Abnormality of the carotid arteries (HP:0005344)1.80896754
107Atresia of the external auditory canal (HP:0000413)1.80777667
108Abnormality of the parietal bone (HP:0002696)1.80278743
109Anomalous pulmonary venous return (HP:0010772)1.79998490
110Bifid tongue (HP:0010297)1.79046478
111Abnormal lung lobation (HP:0002101)1.78847939
112Abnormality of the calcaneus (HP:0008364)1.78565446
113Cerebellar dysplasia (HP:0007033)1.78172982
114Esophageal atresia (HP:0002032)1.77410225
115* Myelodysplasia (HP:0002863)1.77152774
116Selective tooth agenesis (HP:0001592)1.77151437
117* Choanal atresia (HP:0000453)1.75997164
118* Tracheoesophageal fistula (HP:0002575)1.74497257
119Bilateral microphthalmos (HP:0007633)1.74288082
120Premature graying of hair (HP:0002216)1.74028367
121Optic nerve coloboma (HP:0000588)1.73400053
122Abnormality of abdominal situs (HP:0011620)1.73064321
123Abdominal situs inversus (HP:0003363)1.73064321
124Calcaneovalgus deformity (HP:0001848)1.72771409
125Myopathic facies (HP:0002058)1.71687701
126Proximal placement of thumb (HP:0009623)1.71380346
127Severe visual impairment (HP:0001141)1.71282919
128* Abnormality of the duodenum (HP:0002246)1.70665038
129Preaxial hand polydactyly (HP:0001177)1.70572100
130Prolonged bleeding time (HP:0003010)1.70244153
131Birth length less than 3rd percentile (HP:0003561)1.70180737
132* Ectopic kidney (HP:0000086)1.66809879
133Short middle phalanx of the 5th finger (HP:0004220)1.66637936
134Absent septum pellucidum (HP:0001331)1.66365899
135Poor head control (HP:0002421)1.66283809
136Insomnia (HP:0100785)1.64955940
137Deviation of the thumb (HP:0009603)1.64794131
138Respiratory difficulties (HP:0002880)1.64236741
139Down-sloping shoulders (HP:0200021)1.62732734
140Increased CSF lactate (HP:0002490)1.62416730
141Retinal dysplasia (HP:0007973)1.61610780
142Esophageal neoplasm (HP:0100751)1.61464601
143Neoplasm of head and neck (HP:0012288)1.61464601
144Thickened helices (HP:0000391)1.61151973
145Depressed nasal ridge (HP:0000457)1.60826215
146Abnormality of the intervertebral disk (HP:0005108)1.60234086
147Abnormality of the nasolacrimal system (HP:0000614)1.60001631
148Anophthalmia (HP:0000528)1.59110922
149Abnormality of glycolysis (HP:0004366)1.58375262
150Increased muscle lipid content (HP:0009058)1.58302273
151Cortical dysplasia (HP:0002539)1.57909752
152Male pseudohermaphroditism (HP:0000037)1.57782768
153Acute necrotizing encephalopathy (HP:0006965)1.56595765
154Holoprosencephaly (HP:0001360)1.56528155
155Type II lissencephaly (HP:0007260)1.56346760
156Exercise intolerance (HP:0003546)1.55457916

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.68899916
2STK164.49263368
3BLK3.42596770
4GRK13.21550346
5VRK23.13520779
6IRAK32.51135705
7ACVR1B2.33097121
8DYRK32.26068480
9IRAK42.20836681
10TLK12.16586668
11TAF12.15176765
12EIF2AK22.08085966
13SMG12.05496605
14NEK21.94699502
15TESK21.90351786
16CDK71.89776346
17MKNK21.88287964
18MAP3K101.84281784
19PIM21.79156858
20NME21.77292797
21NME11.68257874
22TTK1.67403603
23YES11.64525657
24EPHA21.64082780
25CASK1.59420671
26ADRBK21.55652412
27ZAK1.54243153
28ATR1.52064839
29MAP3K81.51249361
30INSRR1.46273341
31VRK11.45624380
32MKNK11.45303254
33SRPK11.44573170
34TXK1.33400174
35NEK11.29656211
36TSSK61.28385224
37PLK11.24847807
38PIK3CG1.24266430
39CDK81.19270638
40PLK31.18941647
41TRIB31.18296288
42MAP4K21.16981531
43EPHB21.13555706
44EIF2AK11.09445146
45PIM11.08388885
46LATS11.08070741
47RPS6KB21.07839721
48RAF11.06934824
49WEE11.06713106
50PRKCI1.06573039
51CDK121.06003009
52KDR1.05358362
53MAPK151.04804840
54CDK41.03651296
55ICK1.03599706
56PDK21.03572102
57CHEK21.03224448
58BRSK10.98875844
59SIK20.98142617
60CDC70.98055098
61MUSK0.97193856
62ARAF0.96456133
63PLK40.94529806
64MAP4K10.94309380
65TNIK0.92155268
66DYRK20.91519824
67BMPR1B0.91396985
68JAK30.91129471
69CLK10.90620078
70PNCK0.88245005
71BRAF0.88198623
72TRIM280.86884961
73STK100.86138046
74KSR20.83130396
75IKBKB0.81910016
76WNK40.81184134
77MAP3K140.80812129
78MAPKAPK30.79989326
79PBK0.79311220
80AURKB0.79113957
81BRSK20.77723347
82AURKA0.77621319
83MAP2K20.75523794
84BRD40.75185084
85NLK0.73037637
86TEC0.72960268
87AKT20.71782639
88BTK0.68699201
89NUAK10.62518812
90LYN0.62298737
91PASK0.61644760
92RPS6KA40.60589594
93STK40.60491194
94IRAK10.60441891
95BCKDK0.58923455
96EEF2K0.58303090
97MAP2K10.58069132
98ATM0.57872285
99LRRK20.57384133
100SIK30.56966119
101RPS6KC10.56346232
102RPS6KL10.56346232
103RPS6KA60.54491478
104RPS6KA50.53522160
105TAOK20.53085354
106RPS6KA10.52533260
107CCNB10.52299494
108MTOR0.50736884
109PKN20.50520071
110BMX0.50263611
111* CHEK10.49315290
112MAPK110.49239644
113TAOK30.49086932
114TGFBR10.48713937
115CDK60.48562933
116KIT0.48098367
117MAP3K130.47389391
118MELK0.45986845
119CDK90.45648584
120EIF2AK30.45209051
121TRPM70.45016168
122KSR10.44821637
123MOS0.44546581
124TNK20.42933241
125MARK30.42297958
126STK30.40877123
127MAP2K30.40196539
128FGFR30.39907555
129GRK60.39534867
130CDK20.39230105
131AKT10.39098217
132PRKD20.38715113
133CHUK0.37609576
134CSNK2A10.36331179
135PKN10.36207696
136PAK40.35889824
137NEK60.34474288
138GRK70.34161072
139CDK10.32649019
140CAMK1D0.32574693
141MATK0.32554356
142MAP3K90.32169090
143PAK10.31853211
144UHMK10.30705767
145CSNK2A20.30458400
146LCK0.28541126
147ILK0.26923281

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.79864564
2Ribosome_Homo sapiens_hsa030103.71758525
3Mismatch repair_Homo sapiens_hsa034303.52243448
4* Fanconi anemia pathway_Homo sapiens_hsa034603.39830235
5Base excision repair_Homo sapiens_hsa034103.27308629
6Homologous recombination_Homo sapiens_hsa034402.71783772
7RNA polymerase_Homo sapiens_hsa030202.51888179
8Nucleotide excision repair_Homo sapiens_hsa034202.48775677
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.46478896
10Spliceosome_Homo sapiens_hsa030402.39744129
11One carbon pool by folate_Homo sapiens_hsa006702.27155588
12Phototransduction_Homo sapiens_hsa047442.22225150
13Pyrimidine metabolism_Homo sapiens_hsa002402.15875461
14Sulfur relay system_Homo sapiens_hsa041222.01436267
15Non-homologous end-joining_Homo sapiens_hsa034501.93291522
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88618019
17Cell cycle_Homo sapiens_hsa041101.78377200
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68850299
19Basal cell carcinoma_Homo sapiens_hsa052171.68027523
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64804229
21RNA transport_Homo sapiens_hsa030131.58817875
22p53 signaling pathway_Homo sapiens_hsa041151.56033446
23Basal transcription factors_Homo sapiens_hsa030221.53226275
24Notch signaling pathway_Homo sapiens_hsa043301.31881842
25Hedgehog signaling pathway_Homo sapiens_hsa043401.26442698
26Asthma_Homo sapiens_hsa053101.23078621
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.22761428
28mRNA surveillance pathway_Homo sapiens_hsa030151.22480779
29Purine metabolism_Homo sapiens_hsa002301.19351410
30Selenocompound metabolism_Homo sapiens_hsa004501.14996161
31RNA degradation_Homo sapiens_hsa030181.14346988
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12814970
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07768578
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06705864
35Biosynthesis of amino acids_Homo sapiens_hsa012301.04721414
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04520570
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03421079
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01558494
39Pyruvate metabolism_Homo sapiens_hsa006200.99665373
40Huntingtons disease_Homo sapiens_hsa050160.98452082
41Primary immunodeficiency_Homo sapiens_hsa053400.98135216
42Parkinsons disease_Homo sapiens_hsa050120.96132964
43Intestinal immune network for IgA production_Homo sapiens_hsa046720.95164018
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92753316
45Proteasome_Homo sapiens_hsa030500.92352517
46Glycosaminoglycan degradation_Homo sapiens_hsa005310.91932651
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.91647158
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91291327
49Arachidonic acid metabolism_Homo sapiens_hsa005900.90905041
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90059334
51Herpes simplex infection_Homo sapiens_hsa051680.88760861
52Other glycan degradation_Homo sapiens_hsa005110.86797491
53Oocyte meiosis_Homo sapiens_hsa041140.86496415
54MicroRNAs in cancer_Homo sapiens_hsa052060.85806098
55Measles_Homo sapiens_hsa051620.85784555
56Oxidative phosphorylation_Homo sapiens_hsa001900.85455823
57Hematopoietic cell lineage_Homo sapiens_hsa046400.80666710
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79436172
59HTLV-I infection_Homo sapiens_hsa051660.78652862
60Pentose phosphate pathway_Homo sapiens_hsa000300.74179558
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74042823
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.71822984
63Autoimmune thyroid disease_Homo sapiens_hsa053200.71049116
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69761576
65Wnt signaling pathway_Homo sapiens_hsa043100.69564118
66Allograft rejection_Homo sapiens_hsa053300.69532510
67N-Glycan biosynthesis_Homo sapiens_hsa005100.68718300
68Carbon metabolism_Homo sapiens_hsa012000.68038937
69Arginine and proline metabolism_Homo sapiens_hsa003300.67925284
70Hippo signaling pathway_Homo sapiens_hsa043900.67764714
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66146050
72Apoptosis_Homo sapiens_hsa042100.64450453
73Fatty acid elongation_Homo sapiens_hsa000620.62492194
74Systemic lupus erythematosus_Homo sapiens_hsa053220.62356686
75Chronic myeloid leukemia_Homo sapiens_hsa052200.61613057
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61446147
77Thyroid cancer_Homo sapiens_hsa052160.60978401
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60142466
79Melanoma_Homo sapiens_hsa052180.59933906
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59547652
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.59291863
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59110786
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58882993
84Vitamin B6 metabolism_Homo sapiens_hsa007500.58749506
85TGF-beta signaling pathway_Homo sapiens_hsa043500.58600519
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58530572
87Small cell lung cancer_Homo sapiens_hsa052220.57999280
88Pathways in cancer_Homo sapiens_hsa052000.57637016
89Bladder cancer_Homo sapiens_hsa052190.56519375
90Alcoholism_Homo sapiens_hsa050340.53415350
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52660852
92Acute myeloid leukemia_Homo sapiens_hsa052210.52255877
93Epstein-Barr virus infection_Homo sapiens_hsa051690.49812469
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48216706
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47751697
96Graft-versus-host disease_Homo sapiens_hsa053320.46961255
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46265420
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45526952
99Linoleic acid metabolism_Homo sapiens_hsa005910.44723321
100Alzheimers disease_Homo sapiens_hsa050100.44352301
101Steroid biosynthesis_Homo sapiens_hsa001000.43510974
102Sphingolipid metabolism_Homo sapiens_hsa006000.43113500
103Non-small cell lung cancer_Homo sapiens_hsa052230.42567627
104Lysine degradation_Homo sapiens_hsa003100.41769384
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40781277
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39886333
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39800314
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37943725
109Metabolic pathways_Homo sapiens_hsa011000.37178027
110Viral carcinogenesis_Homo sapiens_hsa052030.37136976
111Hepatitis B_Homo sapiens_hsa051610.36144844
112Cardiac muscle contraction_Homo sapiens_hsa042600.36127715
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36027800
114Influenza A_Homo sapiens_hsa051640.35902100
115Glutathione metabolism_Homo sapiens_hsa004800.34090429
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33250623
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32820907
118Nitrogen metabolism_Homo sapiens_hsa009100.32641989
119Colorectal cancer_Homo sapiens_hsa052100.32425423
120Folate biosynthesis_Homo sapiens_hsa007900.32301182
121Prostate cancer_Homo sapiens_hsa052150.31830396
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30802127
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30767643
124ECM-receptor interaction_Homo sapiens_hsa045120.30464220
125Retinol metabolism_Homo sapiens_hsa008300.30383009
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30232800
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.29053204
128Legionellosis_Homo sapiens_hsa051340.28796414
129beta-Alanine metabolism_Homo sapiens_hsa004100.28059827
130Leishmaniasis_Homo sapiens_hsa051400.28004193
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26970968
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26484453
133Propanoate metabolism_Homo sapiens_hsa006400.25587821
134Pancreatic cancer_Homo sapiens_hsa052120.24901832
135Fructose and mannose metabolism_Homo sapiens_hsa000510.23477708
136Shigellosis_Homo sapiens_hsa051310.23420517
137ABC transporters_Homo sapiens_hsa020100.23001433
138Malaria_Homo sapiens_hsa051440.22863143
139Cyanoamino acid metabolism_Homo sapiens_hsa004600.22252680
140Protein export_Homo sapiens_hsa030600.21375192
141Maturity onset diabetes of the young_Homo sapiens_hsa049500.21138579
142Viral myocarditis_Homo sapiens_hsa054160.19025756
143Ras signaling pathway_Homo sapiens_hsa040140.18481409
144Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.18262897

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