FANCF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.28389526
2viral transcription (GO:0019083)5.19258880
3translational termination (GO:0006415)5.15349751
4DNA unwinding involved in DNA replication (GO:0006268)5.08304232
5ribosomal small subunit assembly (GO:0000028)5.00242697
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.85462550
7sequestering of actin monomers (GO:0042989)4.82959774
8cotranslational protein targeting to membrane (GO:0006613)4.77076156
9protein targeting to ER (GO:0045047)4.75099635
10pyrimidine nucleobase catabolic process (GO:0006208)4.73029107
11establishment of protein localization to endoplasmic reticulum (GO:0072599)4.54613336
12translational elongation (GO:0006414)4.52402703
13protein localization to endoplasmic reticulum (GO:0070972)4.49220644
14DNA strand elongation involved in DNA replication (GO:0006271)4.43027158
15telomere maintenance via semi-conservative replication (GO:0032201)4.23867409
16DNA strand elongation (GO:0022616)4.20267639
17maturation of SSU-rRNA (GO:0030490)4.14627968
18DNA replication initiation (GO:0006270)4.07731739
19cellular protein complex disassembly (GO:0043624)4.06568592
20translational initiation (GO:0006413)4.03622675
21epithelial cilium movement (GO:0003351)4.03184582
22folic acid-containing compound biosynthetic process (GO:0009396)4.02089938
23ribosomal small subunit biogenesis (GO:0042274)3.99455295
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.98408634
25viral life cycle (GO:0019058)3.91023653
26DNA damage response, detection of DNA damage (GO:0042769)3.77728409
27nucleobase catabolic process (GO:0046113)3.75274753
28ribosomal large subunit biogenesis (GO:0042273)3.72518253
29behavioral response to nicotine (GO:0035095)3.71572572
30protein complex disassembly (GO:0043241)3.71156765
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.65441531
32intraciliary transport (GO:0042073)3.65052725
33protein localization to kinetochore (GO:0034501)3.61893251
34cilium movement (GO:0003341)3.55402752
35DNA replication checkpoint (GO:0000076)3.52706586
36pteridine-containing compound biosynthetic process (GO:0042559)3.51469961
37macromolecular complex disassembly (GO:0032984)3.47603182
38base-excision repair, AP site formation (GO:0006285)3.46058586
39negative regulation of telomere maintenance (GO:0032205)3.45487485
40telomere maintenance via recombination (GO:0000722)3.44035957
41ubiquinone metabolic process (GO:0006743)3.42970532
42epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.42264711
43mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.41199636
44positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.41199636
45cullin deneddylation (GO:0010388)3.37601388
46olfactory bulb development (GO:0021772)3.32857516
47mitotic recombination (GO:0006312)3.31463744
48energy coupled proton transport, down electrochemical gradient (GO:0015985)3.31083489
49ATP synthesis coupled proton transport (GO:0015986)3.31083489
50pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.30098089
51translation (GO:0006412)3.28994001
52positive regulation of mitochondrial fission (GO:0090141)3.28194939
53neural tube formation (GO:0001841)3.28149804
54tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.26783468
55RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.26783468
56mannosylation (GO:0097502)3.26402159
57ribonucleoprotein complex biogenesis (GO:0022613)3.23866309
58antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.23100070
59antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.23100070
60nonmotile primary cilium assembly (GO:0035058)3.22501735
61formation of translation preinitiation complex (GO:0001731)3.19831779
62nuclear-transcribed mRNA catabolic process (GO:0000956)3.18660610
63protein localization to chromosome, centromeric region (GO:0071459)3.17534048
64telomere maintenance via telomere lengthening (GO:0010833)3.17378177
65somatic diversification of immune receptors via somatic mutation (GO:0002566)3.14429059
66somatic hypermutation of immunoglobulin genes (GO:0016446)3.14429059
67protein targeting to membrane (GO:0006612)3.13927851
68protein neddylation (GO:0045116)3.13281945
69metallo-sulfur cluster assembly (GO:0031163)3.13097214
70iron-sulfur cluster assembly (GO:0016226)3.13097214
71ubiquinone biosynthetic process (GO:0006744)3.12559408
72negative regulation of RNA splicing (GO:0033119)3.10190649
73chaperone-mediated protein transport (GO:0072321)3.09640961
74regulation of helicase activity (GO:0051095)3.08148058
75DNA duplex unwinding (GO:0032508)3.06722719
76protein deneddylation (GO:0000338)3.05107632
77IMP biosynthetic process (GO:0006188)3.03588667
78establishment of protein localization to mitochondrial membrane (GO:0090151)3.02783340
79mRNA catabolic process (GO:0006402)3.02502194
80pentose-phosphate shunt (GO:0006098)3.00857613
81signal peptide processing (GO:0006465)3.00213496
82DNA geometric change (GO:0032392)2.98506439
83RNA catabolic process (GO:0006401)2.97937978
84negative regulation of gene silencing (GO:0060969)2.97635198
85spliceosomal snRNP assembly (GO:0000387)2.97231514
86mitochondrial respiratory chain complex assembly (GO:0033108)2.96960177
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94820408
88rRNA processing (GO:0006364)2.93356470
89mitochondrial respiratory chain complex I assembly (GO:0032981)2.92588299
90NADH dehydrogenase complex assembly (GO:0010257)2.92588299
91mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.92588299
92axonemal dynein complex assembly (GO:0070286)2.92216777
93mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.92197935
94protein complex biogenesis (GO:0070271)2.91929038
95pyrimidine nucleotide catabolic process (GO:0006244)2.91747567
96IMP metabolic process (GO:0046040)2.91061153
97organelle disassembly (GO:1903008)2.90569803
98negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.89716751
99ribonucleoprotein complex disassembly (GO:0032988)2.89144073
100neuron fate determination (GO:0048664)2.88236718
101kinetochore organization (GO:0051383)2.86963771
102GTP biosynthetic process (GO:0006183)2.86267155
103GPI anchor metabolic process (GO:0006505)2.84716833
104cholesterol biosynthetic process (GO:0006695)2.84656211
105mitotic nuclear envelope disassembly (GO:0007077)2.83642118
106histone H4-K12 acetylation (GO:0043983)2.83052609
107rRNA metabolic process (GO:0016072)2.82532589
108protein localization to cilium (GO:0061512)2.81336223
109DNA double-strand break processing (GO:0000729)2.81102308
110cilium or flagellum-dependent cell motility (GO:0001539)2.80867445
111ribosome biogenesis (GO:0042254)2.80681117
112CENP-A containing nucleosome assembly (GO:0034080)2.80419336
113axoneme assembly (GO:0035082)2.79414540
114protein-cofactor linkage (GO:0018065)2.79295002
115deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.79023927
116establishment of integrated proviral latency (GO:0075713)2.78534851
117ribosome assembly (GO:0042255)2.77297543
118attachment of spindle microtubules to kinetochore (GO:0008608)2.77164570
119branched-chain amino acid catabolic process (GO:0009083)2.76790908
120regulation of development, heterochronic (GO:0040034)2.76697434
121negative regulation of mRNA processing (GO:0050686)2.75969259
122chromatin remodeling at centromere (GO:0031055)2.75754649
123mitotic metaphase plate congression (GO:0007080)2.74730924
124regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.74667073
1253-UTR-mediated mRNA stabilization (GO:0070935)2.74506279
126nucleobase biosynthetic process (GO:0046112)2.72338750
127translesion synthesis (GO:0019985)2.71682695
128L-serine metabolic process (GO:0006563)2.71590355
129serine family amino acid catabolic process (GO:0009071)2.70763922
130nucleotide-excision repair, DNA gap filling (GO:0006297)2.67997944
131pseudouridine synthesis (GO:0001522)2.66698119
132tetrahydrofolate metabolic process (GO:0046653)2.65942350
133alpha-linolenic acid metabolic process (GO:0036109)2.65899318
134spermatid nucleus differentiation (GO:0007289)2.65584170
135DNA replication-independent nucleosome organization (GO:0034724)2.65323309
136DNA replication-independent nucleosome assembly (GO:0006336)2.65323309
137preassembly of GPI anchor in ER membrane (GO:0016254)2.64303183
138cilium organization (GO:0044782)2.63315648
139regulation of cilium movement (GO:0003352)2.63256787
140heme biosynthetic process (GO:0006783)2.62764856
141sterol biosynthetic process (GO:0016126)2.62333337
142GPI anchor biosynthetic process (GO:0006506)2.62196804
143histone mRNA metabolic process (GO:0008334)2.61631474
144establishment of viral latency (GO:0019043)2.60203995
145nuclear envelope disassembly (GO:0051081)2.59344576
146membrane disassembly (GO:0030397)2.59344576
147cellular component biogenesis (GO:0044085)2.59241885
148peptidyl-arginine omega-N-methylation (GO:0035247)2.58504512
149cilium assembly (GO:0042384)2.57917817
150nuclear pore complex assembly (GO:0051292)2.56879799
151cilium morphogenesis (GO:0060271)2.56770549
152pteridine-containing compound metabolic process (GO:0042558)2.56725193
153presynaptic membrane assembly (GO:0097105)2.55846581
154regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.55836254
155exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.55673338
156metaphase plate congression (GO:0051310)2.55096969
157mitotic chromosome condensation (GO:0007076)2.54637812
158protein polyglutamylation (GO:0018095)2.53811673
159respiratory chain complex IV assembly (GO:0008535)2.53757872
160regulation of protein heterodimerization activity (GO:0043497)2.53268418
161regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.52215488
162water-soluble vitamin biosynthetic process (GO:0042364)2.51712757
163RNA splicing, via transesterification reactions (GO:0000375)2.51460912
164RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.51076793
165mRNA splicing, via spliceosome (GO:0000398)2.51076793
166DNA integration (GO:0015074)2.50562986
167intracellular protein transmembrane import (GO:0044743)2.49584911
168retinal ganglion cell axon guidance (GO:0031290)2.49549345
169antigen processing and presentation of endogenous antigen (GO:0019883)2.49102058
170regulation of telomere maintenance (GO:0032204)2.48290824
171regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.47740792
172regulation of mitotic spindle checkpoint (GO:1903504)2.47740792
173folic acid metabolic process (GO:0046655)2.47464180
174NADPH regeneration (GO:0006740)2.47263636
175DNA topological change (GO:0006265)2.47153693
176fatty acid elongation (GO:0030497)2.46851491
177microtubule depolymerization (GO:0007019)2.46804054
178regulation of translational fidelity (GO:0006450)2.46614891
179nucleoside diphosphate phosphorylation (GO:0006165)2.46227308
180folic acid-containing compound metabolic process (GO:0006760)2.45646673
181negative regulation of mRNA metabolic process (GO:1903312)2.45422856
182quinone biosynthetic process (GO:1901663)2.44812782
183telomere organization (GO:0032200)2.44618728
184somite development (GO:0061053)2.44465253
185negative regulation of DNA recombination (GO:0045910)2.44462482
186telomere maintenance (GO:0000723)2.44048031
187kinetochore assembly (GO:0051382)2.43024059
188histone-serine phosphorylation (GO:0035404)2.42987608
189mitotic G1 DNA damage checkpoint (GO:0031571)2.42786388
190protein maturation by protein folding (GO:0022417)2.42725209
191termination of RNA polymerase III transcription (GO:0006386)2.41849478
192transcription elongation from RNA polymerase III promoter (GO:0006385)2.41849478
193histone arginine methylation (GO:0034969)2.41140004

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.02880926
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.10221863
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.99323004
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.86060430
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.62923018
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.57557217
7ZNF274_21170338_ChIP-Seq_K562_Hela3.21170083
8IGF1R_20145208_ChIP-Seq_DFB_Human2.91137543
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.77385765
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.75567112
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.75402741
12EZH2_22144423_ChIP-Seq_EOC_Human2.62015698
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.59282820
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50031696
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.47920880
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44619264
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43453554
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42191905
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42053348
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.41495497
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.39442919
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37339574
23IRF1_19129219_ChIP-ChIP_H3396_Human2.35092895
24MYC_22102868_ChIP-Seq_BL_Human2.34649758
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33781938
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.32362999
27XRN2_22483619_ChIP-Seq_HELA_Human2.31210417
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29296927
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.27983917
30TAF15_26573619_Chip-Seq_HEK293_Human2.23841120
31VDR_23849224_ChIP-Seq_CD4+_Human2.17687153
32* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.17151126
33* EWS_26573619_Chip-Seq_HEK293_Human2.15076765
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.13347171
35VDR_22108803_ChIP-Seq_LS180_Human2.12385488
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12224266
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.11475478
38DCP1A_22483619_ChIP-Seq_HELA_Human2.07968479
39POU5F1_16153702_ChIP-ChIP_HESCs_Human2.03384941
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.02124855
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98962678
42FUS_26573619_Chip-Seq_HEK293_Human1.98189126
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98029737
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.97886793
45FOXP3_21729870_ChIP-Seq_TREG_Human1.93684175
46VDR_21846776_ChIP-Seq_THP-1_Human1.91651952
47GABP_19822575_ChIP-Seq_HepG2_Human1.87061995
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83745243
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.77874449
50* SOX2_16153702_ChIP-ChIP_HESCs_Human1.76625298
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73416430
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73123483
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72312079
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.70474582
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.70396678
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69262716
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68969031
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.67458981
59CIITA_25753668_ChIP-Seq_RAJI_Human1.66768364
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66429849
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.65710776
62AR_21909140_ChIP-Seq_LNCAP_Human1.64265528
63TTF2_22483619_ChIP-Seq_HELA_Human1.64194203
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64045205
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62473802
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61302869
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60639314
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58576199
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58424802
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54546844
71ELK1_19687146_ChIP-ChIP_HELA_Human1.52713240
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52273492
73GBX2_23144817_ChIP-Seq_PC3_Human1.51397802
74* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50872126
75P300_19829295_ChIP-Seq_ESCs_Human1.50388464
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47691292
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44920627
78SCL_19346495_ChIP-Seq_HPC-7_Human1.42572238
79KDM5A_27292631_Chip-Seq_BREAST_Human1.42180204
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42088539
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.41157696
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37991718
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.37956180
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34555878
85TFEB_21752829_ChIP-Seq_HELA_Human1.33871239
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33624275
87* MAF_26560356_Chip-Seq_TH1_Human1.33521850
88SPI1_23547873_ChIP-Seq_NB4_Human1.32368544
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.31842197
90RNF2_27304074_Chip-Seq_NSC_Mouse1.31269757
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31258066
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29701813
93UTX_26944678_Chip-Seq_JUKART_Human1.29542420
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27059167
95YY1_21170310_ChIP-Seq_MESCs_Mouse1.26444398
96STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26148459
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26135844
98MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25283429
99SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24622496
100* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23625999
101MYB_26560356_Chip-Seq_TH2_Human1.23129725
102FLI1_27457419_Chip-Seq_LIVER_Mouse1.22356591
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21602775
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21289808
105SRF_21415370_ChIP-Seq_HL-1_Mouse1.17750405
106CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17743571
107VDR_24763502_ChIP-Seq_THP-1_Human1.17647526
108RUNX1_22412390_ChIP-Seq_EML_Mouse1.17378159
109TP53_22573176_ChIP-Seq_HFKS_Human1.16808710
110KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15752348
111POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14559121
112CBX2_27304074_Chip-Seq_ESCs_Mouse1.14375628
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14098454
114ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14081248
115MYB_26560356_Chip-Seq_TH1_Human1.13092146
116YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11429800
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11283604
118ER_23166858_ChIP-Seq_MCF-7_Human1.08157047
119BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07786531
120* NANOG_16153702_ChIP-ChIP_HESCs_Human1.06977169
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06646377
122MAF_26560356_Chip-Seq_TH2_Human1.05115368
123EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04999403
124FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04271910
125CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03264114
126MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03008724
127ELK1_22589737_ChIP-Seq_MCF10A_Human1.02696491
128PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02151208
129CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01606967
130NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99265665
131* CBP_20019798_ChIP-Seq_JUKART_Human0.97581282
132* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97581282
133BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97288456
134NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97002720
135NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96939702
136CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96336039
137PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95919601
138TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94597415
139GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93050496
140TCF7_22412390_ChIP-Seq_EML_Mouse0.92506464
141FOXA1_25329375_ChIP-Seq_VCAP_Human0.91928392
142FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91928392
143MYC_18940864_ChIP-ChIP_HL60_Human0.91814792
144* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90064427
145SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89422667
146AR_20517297_ChIP-Seq_VCAP_Human0.87749384
147TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86771162
148NANOG_19829295_ChIP-Seq_ESCs_Human0.84313688
149SOX2_19829295_ChIP-Seq_ESCs_Human0.84313688
150TAL1_26923725_Chip-Seq_HPCs_Mouse0.83557557
151UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83226361
152TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82748848
153SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82087411
154SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81538723
155ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80999168
156REST_18959480_ChIP-ChIP_MESCs_Mouse0.80457618
157REST_21632747_ChIP-Seq_MESCs_Mouse0.78964240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.71556329
2MP0004957_abnormal_blastocyst_morpholog3.27542410
3MP0010094_abnormal_chromosome_stability3.24453092
4MP0002396_abnormal_hematopoietic_system3.13338864
5MP0003077_abnormal_cell_cycle3.09576291
6MP0003111_abnormal_nucleus_morphology3.05277585
7MP0002822_catalepsy3.03577469
8MP0001529_abnormal_vocalization3.02265863
9MP0002653_abnormal_ependyma_morphology2.88795414
10MP0006292_abnormal_olfactory_placode2.83861268
11MP0003880_abnormal_central_pattern2.68082814
12MP0003763_abnormal_thymus_physiology2.64249989
13MP0008877_abnormal_DNA_methylation2.63067090
14MP0008789_abnormal_olfactory_epithelium2.50173271
15MP0003806_abnormal_nucleotide_metabolis2.49282261
16MP0002638_abnormal_pupillary_reflex2.46452637
17MP0004133_heterotaxia2.46042762
18MP0003787_abnormal_imprinting2.45578841
19MP0003890_abnormal_embryonic-extraembry2.39832502
20MP0005394_taste/olfaction_phenotype2.39119721
21MP0005499_abnormal_olfactory_system2.39119721
22MP0006072_abnormal_retinal_apoptosis2.35376952
23MP0006054_spinal_hemorrhage2.30632030
24MP0008057_abnormal_DNA_replication2.29277330
25MP0000685_abnormal_immune_system2.27164801
26MP0006276_abnormal_autonomic_nervous2.26744369
27MP0001984_abnormal_olfaction2.14784464
28MP0005671_abnormal_response_to2.13234361
29MP0002398_abnormal_bone_marrow2.11505863
30MP0004808_abnormal_hematopoietic_stem2.10686744
31MP0002102_abnormal_ear_morphology2.08965852
32MP0000778_abnormal_nervous_system2.07955626
33MP0003656_abnormal_erythrocyte_physiolo2.07733798
34MP0003121_genomic_imprinting2.06021920
35MP0003122_maternal_imprinting2.03544381
36MP0008007_abnormal_cellular_replicative1.99338159
37MP0000465_gastrointestinal_hemorrhage1.97174677
38MP0008932_abnormal_embryonic_tissue1.96420032
39MP0005645_abnormal_hypothalamus_physiol1.94559812
40MP0009333_abnormal_splenocyte_physiolog1.94168965
41MP0000490_abnormal_crypts_of1.87480904
42MP0000350_abnormal_cell_proliferation1.82211450
43MP0001293_anophthalmia1.81763026
44MP0002751_abnormal_autonomic_nervous1.79112663
45MP0002722_abnormal_immune_system1.78907564
46MP0008995_early_reproductive_senescence1.78815909
47MP0000703_abnormal_thymus_morphology1.77112193
48MP0003136_yellow_coat_color1.72475778
49MP0001730_embryonic_growth_arrest1.70312185
50MP0000631_abnormal_neuroendocrine_gland1.70289315
51MP0005253_abnormal_eye_physiology1.69834258
52MP0001800_abnormal_humoral_immune1.69348536
53MP0005397_hematopoietic_system_phenotyp1.68237082
54MP0001545_abnormal_hematopoietic_system1.68237082
55MP0000689_abnormal_spleen_morphology1.64894749
56MP0000716_abnormal_immune_system1.63579453
57MP0002019_abnormal_tumor_incidence1.63309978
58MP0003718_maternal_effect1.62885763
59MP0002420_abnormal_adaptive_immunity1.62356190
60MP0008058_abnormal_DNA_repair1.61501674
61MP0002429_abnormal_blood_cell1.59242696
62MP0010352_gastrointestinal_tract_polyps1.58892463
63MP0003300_gastrointestinal_ulcer1.58647115
64MP0001819_abnormal_immune_cell1.57955892
65MP0003436_decreased_susceptibility_to1.53797833
66MP0000372_irregular_coat_pigmentation1.52526909
67MP0001188_hyperpigmentation1.49813305
68MP0010307_abnormal_tumor_latency1.49078502
69MP0002723_abnormal_immune_serum1.43718208
70MP0005464_abnormal_platelet_physiology1.42182658
71MP0002452_abnormal_antigen_presenting1.42150590
72MP0002909_abnormal_adrenal_gland1.40718610
73MP0002234_abnormal_pharynx_morphology1.40667091
74MP0003011_delayed_dark_adaptation1.39901454
75MP0005000_abnormal_immune_tolerance1.38130973
76MP0002938_white_spotting1.38067076
77MP0002166_altered_tumor_susceptibility1.36675137
78MP0005084_abnormal_gallbladder_morpholo1.34893062
79MP0003567_abnormal_fetal_cardiomyocyte1.33191334
80MP0003866_abnormal_defecation1.31999243
81MP0000313_abnormal_cell_death1.30218622
82MP0004142_abnormal_muscle_tone1.29922799
83MP0002877_abnormal_melanocyte_morpholog1.29556981
84MP0005025_abnormal_response_to1.28420507
85MP0002405_respiratory_system_inflammati1.28236734
86MP0002928_abnormal_bile_duct1.26345912
87MP0004147_increased_porphyrin_level1.26213845
88MP0003123_paternal_imprinting1.25743243
89MP0003221_abnormal_cardiomyocyte_apopto1.25483753
90MP0001790_abnormal_immune_system1.24649586
91MP0005387_immune_system_phenotype1.24649586
92MP0002736_abnormal_nociception_after1.24242385
93MP0005075_abnormal_melanosome_morpholog1.24112034
94MP0002080_prenatal_lethality1.23495052
95MP0001835_abnormal_antigen_presentation1.22872776
96MP0002233_abnormal_nose_morphology1.22288989
97MP0005551_abnormal_eye_electrophysiolog1.21351187
98MP0001873_stomach_inflammation1.19927878
99MP0001697_abnormal_embryo_size1.18373974
100MP0003315_abnormal_perineum_morphology1.17866003
101MP0005076_abnormal_cell_differentiation1.17222299
102MP0000358_abnormal_cell_content/1.16694278
103MP0004197_abnormal_fetal_growth/weight/1.15690439
104MP0003186_abnormal_redox_activity1.13957007
105MP0003119_abnormal_digestive_system1.13478255
106MP0003172_abnormal_lysosome_physiology1.11533561
107MP0005391_vision/eye_phenotype1.10832160
108MP0002184_abnormal_innervation1.10818868
109MP0006035_abnormal_mitochondrial_morpho1.10440113
110MP0000566_synostosis1.10109412
111MP0001286_abnormal_eye_development1.09438886
112MP0000858_altered_metastatic_potential1.09118311
113MP0001764_abnormal_homeostasis1.07849459
114MP0000049_abnormal_middle_ear1.07783524
115MP0003786_premature_aging1.06594324
116MP0002752_abnormal_somatic_nervous1.04932114
117MP0004947_skin_inflammation1.03311114
118MP0010155_abnormal_intestine_physiology1.03012704
119MP0002557_abnormal_social/conspecific_i1.02647616
120MP0003984_embryonic_growth_retardation1.01302978
121MP0005195_abnormal_posterior_eye1.01136213
122MP0000647_abnormal_sebaceous_gland1.00699492
123MP0005380_embryogenesis_phenotype0.99866012
124MP0001672_abnormal_embryogenesis/_devel0.99866012
125MP0000955_abnormal_spinal_cord0.99420689
126MP0002088_abnormal_embryonic_growth/wei0.98434015
127MP0003303_peritoneal_inflammation0.98183503
128MP0009785_altered_susceptibility_to0.97450236
129MP0006036_abnormal_mitochondrial_physio0.97414199
130MP0001905_abnormal_dopamine_level0.96451423
131MP0001845_abnormal_inflammatory_respons0.96302998
132MP0001915_intracranial_hemorrhage0.96302172
133MP0000026_abnormal_inner_ear0.96286341
134MP0001919_abnormal_reproductive_system0.96053908
135MP0002419_abnormal_innate_immunity0.96049981
136MP0002254_reproductive_system_inflammat0.95725104
137MP0009672_abnormal_birth_weight0.95193563
138MP0002160_abnormal_reproductive_system0.93478699
139MP0005360_urolithiasis0.93373151
140MP0009840_abnormal_foam_cell0.93048066
141MP0002086_abnormal_extraembryonic_tissu0.92989861
142MP0002277_abnormal_respiratory_mucosa0.92421110
143MP0003861_abnormal_nervous_system0.91327156
144MP0005187_abnormal_penis_morphology0.91031234
145MP0005220_abnormal_exocrine_pancreas0.90878118
146MP0004811_abnormal_neuron_physiology0.90457666
147MP0001348_abnormal_lacrimal_gland0.90282150
148MP0002272_abnormal_nervous_system0.89711955
149MP0000598_abnormal_liver_morphology0.89302216
150MP0002067_abnormal_sensory_capabilities0.88589001
151MP0005389_reproductive_system_phenotype0.88461951
152MP0000609_abnormal_liver_physiology0.86378270
153MP0003938_abnormal_ear_development0.85550798
154MP0002882_abnormal_neuron_morphology0.85478337
155MP0001968_abnormal_touch/_nociception0.85388651
156MP0003698_abnormal_male_reproductive0.84723380
157MP0005384_cellular_phenotype0.84647310
158MP0008873_increased_physiological_sensi0.84309566
159MP0001853_heart_inflammation0.84044879
160MP0002210_abnormal_sex_determination0.83616965
161MP0003937_abnormal_limbs/digits/tail_de0.82891539
162MP0001243_abnormal_dermal_layer0.82834633
163MP0000477_abnormal_intestine_morphology0.82514733
164MP0005621_abnormal_cell_physiology0.81858499
165MP0002006_tumorigenesis0.81786748
166MP0001324_abnormal_eye_pigmentation0.81520559
167MP0001929_abnormal_gametogenesis0.81476505
168MP0009046_muscle_twitch0.80870795
169MP0002933_joint_inflammation0.80390117
170MP0009745_abnormal_behavioral_response0.79571007
171MP0004742_abnormal_vestibular_system0.79504615
172MP0001485_abnormal_pinna_reflex0.78207721
173MP0002090_abnormal_vision0.78131619
174MP0002735_abnormal_chemical_nociception0.77423249
175MP0002152_abnormal_brain_morphology0.76887722
176MP0001727_abnormal_embryo_implantation0.76365402
177MP0002085_abnormal_embryonic_tissue0.76284678
178MP0003183_abnormal_peptide_metabolism0.75797960
179MP0002697_abnormal_eye_size0.75717748
180MP0002572_abnormal_emotion/affect_behav0.75687590
181MP0005023_abnormal_wound_healing0.75349107
182MP0004043_abnormal_pH_regulation0.74715717
183MP0000653_abnormal_sex_gland0.74327637
184MP0008875_abnormal_xenobiotic_pharmacok0.74198660
185MP0009697_abnormal_copulation0.74034650
186MP0001145_abnormal_male_reproductive0.72254478
187MP0003950_abnormal_plasma_membrane0.71686566
188MP0001851_eye_inflammation0.69217802
189MP0008469_abnormal_protein_level0.69066417
190MP0005408_hypopigmentation0.66784711

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.69354824
2Abnormal number of erythroid precursors (HP:0012131)4.30896463
3Thrombocytosis (HP:0001894)3.84377038
4IgM deficiency (HP:0002850)3.69685076
5Reticulocytopenia (HP:0001896)3.51522223
6Aplastic anemia (HP:0001915)3.50925749
7Pancreatic fibrosis (HP:0100732)3.49839363
8Medial flaring of the eyebrow (HP:0010747)3.30925604
9True hermaphroditism (HP:0010459)3.27776185
10Pancreatic cysts (HP:0001737)3.26766189
11Molar tooth sign on MRI (HP:0002419)3.23900965
12Abnormality of midbrain morphology (HP:0002418)3.23900965
13Macrocytic anemia (HP:0001972)3.22532605
14Abnormality of the heme biosynthetic pathway (HP:0010472)3.20497289
15Hyperglycinemia (HP:0002154)3.17012818
16Pallor (HP:0000980)3.14417395
17Petechiae (HP:0000967)3.11195552
18Congenital primary aphakia (HP:0007707)3.04185452
19Gait imbalance (HP:0002141)3.02340385
20Acute necrotizing encephalopathy (HP:0006965)3.01279784
21Nephrogenic diabetes insipidus (HP:0009806)2.99561509
22Acute encephalopathy (HP:0006846)2.91311398
23Birth length less than 3rd percentile (HP:0003561)2.91199898
24Nephronophthisis (HP:0000090)2.90893807
25Exertional dyspnea (HP:0002875)2.85811562
26Chronic otitis media (HP:0000389)2.85730265
27Recurrent bronchitis (HP:0002837)2.85108576
28T lymphocytopenia (HP:0005403)2.84313659
29Decreased activity of mitochondrial respiratory chain (HP:0008972)2.84115997
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.84115997
31Abnormality of the labia minora (HP:0012880)2.84084072
32Elevated erythrocyte sedimentation rate (HP:0003565)2.76067225
33Chronic hepatic failure (HP:0100626)2.75518750
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.74846797
35Abnormal mitochondria in muscle tissue (HP:0008316)2.68705980
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.62696375
37Abnormal respiratory motile cilium morphology (HP:0005938)2.62473197
38Abnormal respiratory epithelium morphology (HP:0012253)2.62473197
39Abnormal respiratory motile cilium physiology (HP:0012261)2.62083736
40Abnormality of T cell number (HP:0011839)2.59837824
41Abnormality of T cells (HP:0002843)2.55597794
42Genital tract atresia (HP:0001827)2.55100146
43Abnormal ciliary motility (HP:0012262)2.55032965
44Abnormality of aromatic amino acid family metabolism (HP:0004338)2.53418826
45Abnormality of T cell physiology (HP:0011840)2.53167674
46Polyphagia (HP:0002591)2.52958859
47Retinal dysplasia (HP:0007973)2.51685630
48Vaginal atresia (HP:0000148)2.51256783
49Microretrognathia (HP:0000308)2.46291759
50Chronic bronchitis (HP:0004469)2.44059287
51Broad face (HP:0000283)2.43982160
52Lissencephaly (HP:0001339)2.43287505
53Progressive macrocephaly (HP:0004481)2.42995654
54Cortical dysplasia (HP:0002539)2.41903238
55Amaurosis fugax (HP:0100576)2.41648004
56Hyperglycinuria (HP:0003108)2.39588361
5711 pairs of ribs (HP:0000878)2.37726850
58Poor coordination (HP:0002370)2.34498080
59Rhinitis (HP:0012384)2.34039571
60Ragged-red muscle fibers (HP:0003200)2.33712179
61Abnormal hemoglobin (HP:0011902)2.33589884
62Abnormality of reticulocytes (HP:0004312)2.32474751
63Abnormality of the renal medulla (HP:0100957)2.32246931
64Abnormality of glycine metabolism (HP:0010895)2.31674961
65Abnormality of serine family amino acid metabolism (HP:0010894)2.31674961
66Postaxial foot polydactyly (HP:0001830)2.30808314
67Lymphoma (HP:0002665)2.29730032
68Methylmalonic acidemia (HP:0002912)2.25843729
69Recurrent viral infections (HP:0004429)2.24464256
70Entropion (HP:0000621)2.23791436
71Abnormal biliary tract physiology (HP:0012439)2.23679802
72Bile duct proliferation (HP:0001408)2.23679802
73Preaxial hand polydactyly (HP:0001177)2.22845885
74Failure to thrive in infancy (HP:0001531)2.20493080
75Poikiloderma (HP:0001029)2.19849538
76Prolonged bleeding time (HP:0003010)2.18837894
77Anencephaly (HP:0002323)2.17814352
78Type II lissencephaly (HP:0007260)2.17273773
79IgG deficiency (HP:0004315)2.16902939
80Basal cell carcinoma (HP:0002671)2.16105367
81Intestinal atresia (HP:0011100)2.14877348
82Hypoplasia of the thymus (HP:0000778)2.14782594
83Broad foot (HP:0001769)2.14762681
84Stomatitis (HP:0010280)2.14217416
85Postaxial hand polydactyly (HP:0001162)2.14050508
86Hepatocellular necrosis (HP:0001404)2.13949216
87Occipital encephalocele (HP:0002085)2.13644278
88Ependymoma (HP:0002888)2.13386287
89Aplasia/Hypoplasia of the spleen (HP:0010451)2.13011190
90Methylmalonic aciduria (HP:0012120)2.12976870
913-Methylglutaconic aciduria (HP:0003535)2.12764503
92Selective tooth agenesis (HP:0001592)2.12441392
93Sclerocornea (HP:0000647)2.12370253
94Lipid accumulation in hepatocytes (HP:0006561)2.12253543
95Oral leukoplakia (HP:0002745)2.12107306
96Cerebral edema (HP:0002181)2.10664432
97Vacuolated lymphocytes (HP:0001922)2.08779906
98Premature graying of hair (HP:0002216)2.07526254
99Increased serum lactate (HP:0002151)2.07353806
100Absent thumb (HP:0009777)2.07296744
101Pancytopenia (HP:0001876)2.06133023
102Abnormal protein glycosylation (HP:0012346)2.05950771
103Abnormal glycosylation (HP:0012345)2.05950771
104Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05950771
105Abnormal protein N-linked glycosylation (HP:0012347)2.05950771
106Specific learning disability (HP:0001328)2.04440908
107Hepatic necrosis (HP:0002605)2.04406276
108Abnormal platelet function (HP:0011869)2.03744650
109Impaired platelet aggregation (HP:0003540)2.03744650
110Type I transferrin isoform profile (HP:0003642)2.03546587
111Aplasia/Hypoplasia of the tongue (HP:0010295)2.02393494
112Epistaxis (HP:0000421)2.00982729
113Asplenia (HP:0001746)2.00746528
114* Myelodysplasia (HP:0002863)1.99076539
115Cerebral hypomyelination (HP:0006808)1.98765059
116Septo-optic dysplasia (HP:0100842)1.98093146
117Supernumerary spleens (HP:0009799)1.98037968
118Abolished electroretinogram (ERG) (HP:0000550)1.98001006
119Increased hepatocellular lipid droplets (HP:0006565)1.96566955
120Abnormal platelet volume (HP:0011876)1.95816294
121Agnosia (HP:0010524)1.91806385
122Abnormality of cells of the lymphoid lineage (HP:0012140)1.91749998
123Cystic liver disease (HP:0006706)1.91744928
124Colon cancer (HP:0003003)1.91740454
125Lymphopenia (HP:0001888)1.91425906
126Increased intramyocellular lipid droplets (HP:0012240)1.90889959
127Acanthocytosis (HP:0001927)1.86991094
128IgA deficiency (HP:0002720)1.86136582
129Increased muscle lipid content (HP:0009058)1.86087279
130Bifid tongue (HP:0010297)1.86031201
131Hyperbilirubinemia (HP:0002904)1.85466310
132Hypothermia (HP:0002045)1.84953510
133Congenital hepatic fibrosis (HP:0002612)1.84776850
134Dandy-Walker malformation (HP:0001305)1.83850206
135Spastic diplegia (HP:0001264)1.83825520
136Pachygyria (HP:0001302)1.83308180
137Optic nerve hypoplasia (HP:0000609)1.80660600
138Optic disc pallor (HP:0000543)1.80476742
139Increased mean platelet volume (HP:0011877)1.79673896
140Spastic paraparesis (HP:0002313)1.78915888
141Short tibia (HP:0005736)1.78856000
142Medulloblastoma (HP:0002885)1.78821830
143Patellar aplasia (HP:0006443)1.78788754
144Median cleft lip (HP:0000161)1.78186409
145Increased serum ferritin (HP:0003281)1.77748602
146Increased CSF lactate (HP:0002490)1.77240534
147Narrow forehead (HP:0000341)1.77150656
148Anophthalmia (HP:0000528)1.75028142
149Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75013007
150Abnormality of the umbilical cord (HP:0010881)1.74961540
151Increased nuchal translucency (HP:0010880)1.74915317
152Decreased testicular size (HP:0008734)1.74692821
153Renal Fanconi syndrome (HP:0001994)1.74022340
154Brushfield spots (HP:0001088)1.73866012
155Trismus (HP:0000211)1.73795312
156Thoracolumbar scoliosis (HP:0002944)1.72861688
157Mitochondrial inheritance (HP:0001427)1.72555843
158Abnormality of B cell number (HP:0010975)1.72101381
159B lymphocytopenia (HP:0010976)1.72101381
160Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.71521366
161Growth hormone deficiency (HP:0000824)1.71499615
162Proximal placement of thumb (HP:0009623)1.71480390
163Lactic acidosis (HP:0003128)1.70850721
164Tubulointerstitial nephritis (HP:0001970)1.70286927
165Respiratory difficulties (HP:0002880)1.69966536
166Agitation (HP:0000713)1.69596133
167Dynein arm defect of respiratory motile cilia (HP:0012255)1.69565138
168Absent/shortened dynein arms (HP:0200106)1.69565138
169Lethargy (HP:0001254)1.69097533
170Abnormality of the fetal cardiovascular system (HP:0010948)1.68715056
171Abnormal umbilical cord blood vessels (HP:0011403)1.68715056
172Single umbilical artery (HP:0001195)1.68715056
173Pendular nystagmus (HP:0012043)1.68707423
174Neutropenia (HP:0001875)1.68321016
175Increased density of long bones (HP:0006392)1.68288368
176Poor suck (HP:0002033)1.67717988
177Aplasia/Hypoplasia of the tibia (HP:0005772)1.66589016
178* Abnormality of chromosome stability (HP:0003220)1.66378140
179Male pseudohermaphroditism (HP:0000037)1.66287093
180Reticulocytosis (HP:0001923)1.65510548
181Hemivertebrae (HP:0002937)1.64967133
182Panhypogammaglobulinemia (HP:0003139)1.63925683
183Abnormality of the vasculature of the conjunctiva (HP:0008054)1.63632437
184Prominent nose (HP:0000448)1.62589522
185Conjugated hyperbilirubinemia (HP:0002908)1.61236299
186Reduced antithrombin III activity (HP:0001976)1.59937154
187Opisthotonus (HP:0002179)1.57414338

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.20273279
2MAP4K24.00228328
3TRIM283.74022810
4MAP4K13.37671120
5NME23.18595249
6WEE13.02581359
7MAP2K73.01810274
8MAP3K42.96505194
9SCYL22.84441181
10BCR2.82706517
11TESK22.81972351
12BCKDK2.81249361
13EEF2K2.76632213
14CDC72.73765753
15BRSK22.57990618
16EIF2AK12.50700011
17MAP3K102.19027459
18BRSK12.18254387
19DYRK22.18162653
20WNK32.16705775
21NUAK12.15326680
22ZAK2.10613501
23VRK22.06379749
24EPHA32.05110986
25TAF12.01769675
26TLK11.94359740
27PKN21.79274553
28EIF2AK31.78038118
29PIM21.75001636
30ZAP701.74410011
31FLT31.73277001
32MAPK151.69186386
33JAK31.60876456
34CASK1.59099083
35STK101.55553950
36CSNK1G21.52159123
37VRK11.51006442
38NEK21.50086926
39TRIB31.49307363
40RPS6KB21.47774691
41ACVR1B1.47607033
42CSNK1G31.46094995
43PASK1.43900922
44BTK1.43428259
45MARK11.40753776
46KDR1.39180603
47SRPK11.39008698
48ERBB31.37469317
49CSNK1G11.37462155
50ITK1.34341275
51RPS6KA41.34245025
52BMPR1B1.30304517
53TXK1.28871344
54MAPK131.27990445
55CSNK1A1L1.25074316
56TYK21.19850978
57CDK121.19237692
58ILK1.16831875
59ERN11.12729038
60KSR11.12146691
61ATR1.10987315
62LRRK21.10431724
63MAP2K41.09023283
64TEC1.06679527
65PINK11.05943955
66PLK11.00993753
67CDK40.99189609
68MAP3K110.98192360
69TSSK60.97193432
70PLK30.97125572
71PAK30.96545233
72CHEK20.95146623
73AURKA0.93068679
74AURKB0.92338176
75NEK10.92011221
76FRK0.91658347
77SIK30.91347681
78MAP3K80.86616769
79MAPKAPK30.85269028
80ADRBK20.84547338
81PIM10.82421615
82TNIK0.81959652
83GRK60.81755539
84DYRK30.81709375
85PLK40.81408933
86GRK10.80329054
87RPS6KA50.80169850
88MKNK20.78103010
89EPHA40.77708222
90CDK70.77563245
91CHEK10.76347497
92CDK60.75700401
93FGFR40.73149764
94TAOK30.69867981
95TTK0.69075317
96FGFR10.69038965
97HIPK20.68239303
98PRKCG0.67473345
99LCK0.66348388
100UHMK10.66050834
101CDK190.65130315
102MINK10.64344846
103SYK0.62355176
104CDK30.62192619
105DYRK1A0.60870350
106STK160.60570935
107MELK0.60331403
108KIT0.59912654
109ALK0.59835522
110PAK40.58962941
111NME10.58942937
112STK40.58397744
113OXSR10.58319697
114MAPK110.57808169
115WNK40.57726521
116PRKCE0.55264195
117LIMK10.54326063
118PBK0.51375967
119TBK10.50876237
120CSNK2A20.50210445
121CSNK1A10.48827063
122TNK20.48416192
123CSF1R0.47856864
124BLK0.46200879
125MATK0.46012556
126LYN0.45998997
127BRD40.45606394
128CDK20.44801020
129ATM0.43165930
130RAF10.42641759
131CLK10.40810509
132MAPKAPK20.39697868
133EPHB20.39447207
134PAK20.38558371
135TESK10.38441009
136MKNK10.38017721
137NTRK20.37445051
138FGFR20.35062149
139HCK0.34908035
140MTOR0.34370774
141MST40.33365721
142PRKCZ0.32737937
143CDK10.31790085
144IKBKB0.31262588
145PKN10.30434208
146CDK80.30273587
147MET0.30138283
148RPS6KA60.29800348
149CSNK1E0.29643767
150MUSK0.29235767
151AKT30.29198649
152PAK10.28296221
153CDK140.27909784
154CSNK2A10.27800127
155DYRK1B0.27733276
156INSRR0.27570221
157MAPKAPK50.27534898
158CAMK2A0.27435348
159TGFBR10.27156490
160PLK20.26645019
161PRKCQ0.26204507
162PRKACA0.25449430
163NLK0.24942280
164CDK180.24313294
165EPHB10.22930513
166DAPK20.22730720

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.63842286
2Ribosome_Homo sapiens_hsa030104.33990295
3Mismatch repair_Homo sapiens_hsa034303.37051923
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.09180739
5Protein export_Homo sapiens_hsa030602.94355229
6Spliceosome_Homo sapiens_hsa030402.81989361
7One carbon pool by folate_Homo sapiens_hsa006702.64547978
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50947932
9RNA polymerase_Homo sapiens_hsa030202.48690426
10Steroid biosynthesis_Homo sapiens_hsa001002.39035542
11Homologous recombination_Homo sapiens_hsa034402.38170991
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.22382936
13Cell cycle_Homo sapiens_hsa041102.19643061
14Nucleotide excision repair_Homo sapiens_hsa034202.15655049
15Pyrimidine metabolism_Homo sapiens_hsa002402.09188384
16Proteasome_Homo sapiens_hsa030502.07256766
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97793174
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93256696
19RNA transport_Homo sapiens_hsa030131.92138778
20Propanoate metabolism_Homo sapiens_hsa006401.91796319
21Base excision repair_Homo sapiens_hsa034101.89172695
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.87892126
23Systemic lupus erythematosus_Homo sapiens_hsa053221.81307366
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.74224322
25Butanoate metabolism_Homo sapiens_hsa006501.67630680
26Nicotine addiction_Homo sapiens_hsa050331.62836110
27Primary immunodeficiency_Homo sapiens_hsa053401.58662545
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.55745316
29Alzheimers disease_Homo sapiens_hsa050101.47290541
30Selenocompound metabolism_Homo sapiens_hsa004501.42513038
31Antigen processing and presentation_Homo sapiens_hsa046121.41040595
32Non-homologous end-joining_Homo sapiens_hsa034501.38468303
33Pentose phosphate pathway_Homo sapiens_hsa000301.36321999
34Phototransduction_Homo sapiens_hsa047441.32556043
35* Fanconi anemia pathway_Homo sapiens_hsa034601.31668276
36RNA degradation_Homo sapiens_hsa030181.29684477
37Folate biosynthesis_Homo sapiens_hsa007901.23549276
38N-Glycan biosynthesis_Homo sapiens_hsa005101.21730443
39p53 signaling pathway_Homo sapiens_hsa041151.19395463
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16860773
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.14687573
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12591690
43Linoleic acid metabolism_Homo sapiens_hsa005911.11780762
44Herpes simplex infection_Homo sapiens_hsa051681.05064062
45Viral carcinogenesis_Homo sapiens_hsa052031.05040443
46Basal transcription factors_Homo sapiens_hsa030221.04166467
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.02719045
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02093329
49Epstein-Barr virus infection_Homo sapiens_hsa051690.98398868
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98387789
51Measles_Homo sapiens_hsa051620.97665905
52Hematopoietic cell lineage_Homo sapiens_hsa046400.96696070
53Cardiac muscle contraction_Homo sapiens_hsa042600.96406101
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93046129
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.92649706
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.90527425
57Vitamin digestion and absorption_Homo sapiens_hsa049770.89260083
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88813508
59Biosynthesis of amino acids_Homo sapiens_hsa012300.88128423
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85857210
61T cell receptor signaling pathway_Homo sapiens_hsa046600.85822173
62Taste transduction_Homo sapiens_hsa047420.83929058
63Sulfur relay system_Homo sapiens_hsa041220.83503588
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82195078
65Regulation of autophagy_Homo sapiens_hsa041400.80579145
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79663076
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79130672
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77981546
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76333217
70Purine metabolism_Homo sapiens_hsa002300.75929238
71Pyruvate metabolism_Homo sapiens_hsa006200.75908625
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74642618
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.73365064
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73341890
75mRNA surveillance pathway_Homo sapiens_hsa030150.73176826
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.72975722
77Alcoholism_Homo sapiens_hsa050340.71094181
78Fatty acid metabolism_Homo sapiens_hsa012120.70135087
79Hepatitis B_Homo sapiens_hsa051610.66978392
80Apoptosis_Homo sapiens_hsa042100.66317216
81Retinol metabolism_Homo sapiens_hsa008300.66167678
82Collecting duct acid secretion_Homo sapiens_hsa049660.65813133
83HTLV-I infection_Homo sapiens_hsa051660.65437505
84Acute myeloid leukemia_Homo sapiens_hsa052210.63936830
85Chemical carcinogenesis_Homo sapiens_hsa052040.63570943
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63423576
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61165744
88B cell receptor signaling pathway_Homo sapiens_hsa046620.60927793
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60644696
90Parkinsons disease_Homo sapiens_hsa050120.60334406
91Chronic myeloid leukemia_Homo sapiens_hsa052200.59847365
92Legionellosis_Homo sapiens_hsa051340.58795554
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58194626
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.56801193
95Ether lipid metabolism_Homo sapiens_hsa005650.55246095
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54863216
97Basal cell carcinoma_Homo sapiens_hsa052170.54452445
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53891355
99GABAergic synapse_Homo sapiens_hsa047270.53878268
100Tryptophan metabolism_Homo sapiens_hsa003800.53643030
101Glutathione metabolism_Homo sapiens_hsa004800.52434026
102Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52417539
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51948890
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50597117
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48857091
106Vitamin B6 metabolism_Homo sapiens_hsa007500.48115782
107Arachidonic acid metabolism_Homo sapiens_hsa005900.47421743
108Axon guidance_Homo sapiens_hsa043600.46753234
109Fatty acid elongation_Homo sapiens_hsa000620.45098996
110Leishmaniasis_Homo sapiens_hsa051400.44188718
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43430185
112Colorectal cancer_Homo sapiens_hsa052100.43100769
113Other glycan degradation_Homo sapiens_hsa005110.42163727
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41965884
115Thyroid cancer_Homo sapiens_hsa052160.41582638
116Shigellosis_Homo sapiens_hsa051310.41263086
117Caffeine metabolism_Homo sapiens_hsa002320.41158728
118Carbon metabolism_Homo sapiens_hsa012000.40917368
119Small cell lung cancer_Homo sapiens_hsa052220.40759972
120Oocyte meiosis_Homo sapiens_hsa041140.40689628
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39492794
122Hedgehog signaling pathway_Homo sapiens_hsa043400.38716104
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38137463
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37996015
125Peroxisome_Homo sapiens_hsa041460.36507096
126Olfactory transduction_Homo sapiens_hsa047400.36358220
127Sulfur metabolism_Homo sapiens_hsa009200.36299400
128Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34622828
129Cocaine addiction_Homo sapiens_hsa050300.34038354
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34016579
131Pancreatic cancer_Homo sapiens_hsa052120.33206300
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33140374
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33108259
134Serotonergic synapse_Homo sapiens_hsa047260.32851817
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32662354
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32656852
137Huntingtons disease_Homo sapiens_hsa050160.30449691
138Fat digestion and absorption_Homo sapiens_hsa049750.29611728
139Non-small cell lung cancer_Homo sapiens_hsa052230.29234483
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.28766291
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27213306
142MicroRNAs in cancer_Homo sapiens_hsa052060.26645080
143Dopaminergic synapse_Homo sapiens_hsa047280.25792862
144Bladder cancer_Homo sapiens_hsa052190.25733460
145Oxidative phosphorylation_Homo sapiens_hsa001900.25192045
146Metabolic pathways_Homo sapiens_hsa011000.24988800
147Osteoclast differentiation_Homo sapiens_hsa043800.24850667
148Jak-STAT signaling pathway_Homo sapiens_hsa046300.24504704
149Leukocyte transendothelial migration_Homo sapiens_hsa046700.23986172
150Allograft rejection_Homo sapiens_hsa053300.22830121

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