FANCI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group I. Alternative splicing results in two transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.87227671
2daunorubicin metabolic process (GO:0044597)6.24453068
3polyketide metabolic process (GO:0030638)6.24453068
4doxorubicin metabolic process (GO:0044598)6.24453068
5mitotic sister chromatid segregation (GO:0000070)5.71794824
6protein localization to chromosome, centromeric region (GO:0071459)5.56539911
7nuclear pore complex assembly (GO:0051292)5.45208876
8regulation of nuclear cell cycle DNA replication (GO:0033262)5.31531004
9regulation of telomere maintenance via telomerase (GO:0032210)5.25403269
10nuclear pore organization (GO:0006999)5.21746721
11sister chromatid segregation (GO:0000819)5.13542430
12DNA replication-dependent nucleosome assembly (GO:0006335)5.11467790
13DNA replication-dependent nucleosome organization (GO:0034723)5.11467790
14mitotic sister chromatid cohesion (GO:0007064)4.97740668
15negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.94116543
16telomere maintenance via recombination (GO:0000722)4.83723935
17DNA replication checkpoint (GO:0000076)4.69048510
18negative regulation of cell cycle G2/M phase transition (GO:1902750)4.55167653
19histone H4-K12 acetylation (GO:0043983)4.53404068
20DNA topological change (GO:0006265)4.52765145
21mitotic chromosome condensation (GO:0007076)4.49277626
22negative regulation of telomerase activity (GO:0051974)4.45753060
23DNA unwinding involved in DNA replication (GO:0006268)4.42129865
24heterochromatin organization (GO:0070828)4.36252140
25regulation of mammary gland epithelial cell proliferation (GO:0033599)4.23598368
26pore complex assembly (GO:0046931)4.21351810
27histone H4-K8 acetylation (GO:0043982)4.19951577
28histone H4-K5 acetylation (GO:0043981)4.19951577
29nucleotide-excision repair, DNA gap filling (GO:0006297)4.19440057
30positive regulation of DNA-dependent DNA replication (GO:2000105)4.17874357
31DNA replication initiation (GO:0006270)4.17772372
32maintenance of protein location in nucleus (GO:0051457)4.15240551
33chromatin assembly (GO:0031497)4.13396741
34DNA ligation (GO:0006266)4.11797948
35regulation of centriole replication (GO:0046599)4.10936891
36DNA duplex unwinding (GO:0032508)4.09200595
37DNA geometric change (GO:0032392)4.08167176
38establishment of integrated proviral latency (GO:0075713)4.05510794
39negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.97855993
40negative regulation of epidermis development (GO:0045683)3.88914264
41non-recombinational repair (GO:0000726)3.88506427
42double-strand break repair via nonhomologous end joining (GO:0006303)3.88506427
43positive regulation of chromosome segregation (GO:0051984)3.87946339
44regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.87553870
45regulation of DNA endoreduplication (GO:0032875)3.86165401
46histone exchange (GO:0043486)3.86146034
47aminoglycoside antibiotic metabolic process (GO:0030647)3.85128988
48telomere maintenance via telomere lengthening (GO:0010833)3.80966877
49DNA synthesis involved in DNA repair (GO:0000731)3.80004577
50negative regulation of telomere maintenance (GO:0032205)3.79371019
51pre-miRNA processing (GO:0031054)3.77603393
52rRNA transcription (GO:0009303)3.75580617
53establishment of chromosome localization (GO:0051303)3.74724001
54regulation of sister chromatid cohesion (GO:0007063)3.67959681
55mitotic nuclear envelope disassembly (GO:0007077)3.66464772
56mitotic metaphase plate congression (GO:0007080)3.65505146
57attachment of spindle microtubules to kinetochore (GO:0008608)3.65126818
58somite rostral/caudal axis specification (GO:0032525)3.64680164
59notochord development (GO:0030903)3.61875076
60regulation of translation in response to stress (GO:0043555)3.59074204
61regulation of centrosome cycle (GO:0046605)3.54224869
62regulation of translational fidelity (GO:0006450)3.54152237
63regulation of gene silencing by RNA (GO:0060966)3.54049799
64regulation of posttranscriptional gene silencing (GO:0060147)3.54049799
65regulation of gene silencing by miRNA (GO:0060964)3.54049799
66kinetochore assembly (GO:0051382)3.52527428
67negative regulation of mitotic sister chromatid separation (GO:2000816)3.52301718
68negative regulation of sister chromatid segregation (GO:0033046)3.52301718
69negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.52301718
70negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.52301718
71negative regulation of mitotic sister chromatid segregation (GO:0033048)3.52301718
72mitotic spindle checkpoint (GO:0071174)3.50862677
73regulation of mitotic metaphase/anaphase transition (GO:0030071)3.48625900
74regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.48625900
75purine nucleobase biosynthetic process (GO:0009113)3.48500660
76formation of translation preinitiation complex (GO:0001731)3.48216880
77rRNA methylation (GO:0031167)3.47181644
78ribosome biogenesis (GO:0042254)3.45260654
79regulation of mitotic sister chromatid separation (GO:0010965)3.45123561
80regulation of mitotic sister chromatid segregation (GO:0033047)3.45123561
81regulation of sister chromatid segregation (GO:0033045)3.45123561
82regulation of spindle organization (GO:0090224)3.44202343
83rRNA modification (GO:0000154)3.43546963
84mitotic spindle assembly checkpoint (GO:0007094)3.42449238
85protein localization to chromosome (GO:0034502)3.42068761
86nucleobase biosynthetic process (GO:0046112)3.41293156
87regulation of response to osmotic stress (GO:0047484)3.39796133
88regulation of mitotic spindle organization (GO:0060236)3.38392717
89membrane disassembly (GO:0030397)3.37930390
90nuclear envelope disassembly (GO:0051081)3.37930390
91DNA conformation change (GO:0071103)3.36670996
92ATP-dependent chromatin remodeling (GO:0043044)3.35389185
93chromatin assembly or disassembly (GO:0006333)3.33447239
94positive regulation of mitotic sister chromatid separation (GO:1901970)3.32698992
95positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.32698992
96positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.32698992
97regulation of telomere maintenance (GO:0032204)3.32411540
98muscle organ morphogenesis (GO:0048644)3.30432754
99regulation of double-strand break repair (GO:2000779)3.29052519
100regulation of MHC class I biosynthetic process (GO:0045343)3.27719260
101DNA strand elongation involved in DNA replication (GO:0006271)3.26031762
102mitotic cell cycle (GO:0000278)3.25420070
103RNA stabilization (GO:0043489)3.24889812
104mRNA stabilization (GO:0048255)3.24889812
105telomere maintenance (GO:0000723)3.24194011
106telomere organization (GO:0032200)3.22914173
107DNA strand renaturation (GO:0000733)3.22418883
108regulation of DNA-dependent DNA replication (GO:0090329)3.20888318
109negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.20000188
110replication fork processing (GO:0031297)3.18715336
111DNA strand elongation (GO:0022616)3.18230062
112histone H4-K16 acetylation (GO:0043984)3.17373066
113sister chromatid cohesion (GO:0007062)3.17098398
114somatic hypermutation of immunoglobulin genes (GO:0016446)3.16920368
115somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16920368
116spindle assembly (GO:0051225)3.14636186
117regulation of centrosome duplication (GO:0010824)3.14052985
118metaphase plate congression (GO:0051310)3.13846194
119negative regulation of epidermal cell differentiation (GO:0045605)3.13820096
120chromosome condensation (GO:0030261)3.13651162
121chromosome organization (GO:0051276)3.11682953
122microtubule depolymerization (GO:0007019)3.09683930
123DNA replication (GO:0006260)3.08926937
124telomere maintenance via semi-conservative replication (GO:0032201)3.04495310
125chromosome segregation (GO:0007059)3.03150501
126folic acid-containing compound biosynthetic process (GO:0009396)3.02910481
127regulation of histone H3-K9 methylation (GO:0051570)3.02257712
128regulation of gene silencing (GO:0060968)3.01764772
129regulation of double-strand break repair via homologous recombination (GO:0010569)3.01098516
130chromatin remodeling at centromere (GO:0031055)3.00157747
131spindle assembly checkpoint (GO:0071173)2.98256712
132DNA replication-independent nucleosome organization (GO:0034724)2.94089152
133DNA replication-independent nucleosome assembly (GO:0006336)2.94089152
134mitotic recombination (GO:0006312)2.94040101
135mitotic G2/M transition checkpoint (GO:0044818)2.93964277
136kinetochore organization (GO:0051383)2.93828637
137CENP-A containing nucleosome assembly (GO:0034080)2.93434759
138DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.91479866
139regulation of chromosome segregation (GO:0051983)2.91210494
140spindle checkpoint (GO:0031577)2.90171160
141regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.88073538
142IMP biosynthetic process (GO:0006188)2.86735313
143negative regulation of chromosome segregation (GO:0051985)2.86304806
144meiotic chromosome segregation (GO:0045132)2.85747998
145protein K6-linked ubiquitination (GO:0085020)2.83555927
146negative regulation of gene silencing (GO:0060969)2.83052370
147DNA packaging (GO:0006323)2.82803933
148intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.82327892
149trophectodermal cell differentiation (GO:0001829)2.81655539
150interferon-gamma production (GO:0032609)2.80613025

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* E2F7_22180533_ChIP-Seq_HELA_Human8.13145942
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.78604282
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.42742325
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.42742325
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.42742325
6E2F4_17652178_ChIP-ChIP_JURKAT_Human4.17464213
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.28106783
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.11508851
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.06603107
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.97289273
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.83667281
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.73239364
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45772297
14NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.45033304
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.43019725
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28205785
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.22053780
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.18010321
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.17484853
20SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.10537945
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09018597
22NANOG_18555785_ChIP-Seq_MESCs_Mouse2.01060278
23TCF3_18692474_ChIP-Seq_MESCs_Mouse2.00954517
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98677569
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.97712993
26TCF3_18692474_ChIP-Seq_MEFs_Mouse1.97077977
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.93671033
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.87640576
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85449223
30POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.84172404
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81877074
32STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76468590
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.73554181
34SOX2_18555785_ChIP-Seq_MESCs_Mouse1.72033876
35AR_21909140_ChIP-Seq_LNCAP_Human1.71514976
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71064528
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.70362090
38NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.70007375
39MYC_22102868_ChIP-Seq_BL_Human1.66770528
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66246077
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.62384227
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.61622466
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56448446
44KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.49875170
45NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.49388382
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44423185
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43707403
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.43163765
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40747599
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40543807
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.40504328
52XRN2_22483619_ChIP-Seq_HELA_Human1.39956763
53FOXP3_21729870_ChIP-Seq_TREG_Human1.39794113
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39277626
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39226993
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37746032
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.37374602
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37224916
59* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.34148447
60POU5F1_16518401_ChIP-PET_MESCs_Mouse1.28546425
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.28161364
62JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.27971751
63VDR_23849224_ChIP-Seq_CD4+_Human1.25799840
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24383289
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24148285
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22297891
67IRF1_19129219_ChIP-ChIP_H3396_Human1.21271054
68KDM5A_27292631_Chip-Seq_BREAST_Human1.19004576
69NANOG_18692474_ChIP-Seq_MESCs_Mouse1.18022303
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17918045
71TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.17865161
72NANOG_21062744_ChIP-ChIP_HESCs_Human1.17839030
73POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.17764078
74SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17017750
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.16255479
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15563321
77CIITA_25753668_ChIP-Seq_RAJI_Human1.15542518
78NANOG_18692474_ChIP-Seq_MEFs_Mouse1.15051522
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14512850
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14487732
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14166192
82GABP_17652178_ChIP-ChIP_JURKAT_Human1.13374794
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11005827
84* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10667115
85* TTF2_22483619_ChIP-Seq_HELA_Human1.09430286
86MYC_18940864_ChIP-ChIP_HL60_Human1.09171819
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05516883
88OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05128606
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04886918
90* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03099179
91SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02970141
92* GABP_19822575_ChIP-Seq_HepG2_Human1.02866687
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02407126
94NANOG_16153702_ChIP-ChIP_HESCs_Human1.02400878
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02011321
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01694080
97* SRF_21415370_ChIP-Seq_HL-1_Mouse1.00282445
98ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98859375
99ELK1_19687146_ChIP-ChIP_HELA_Human0.96862105
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96853573
101HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96316886
102* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95345718
103* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94823713
104TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94524974
105DCP1A_22483619_ChIP-Seq_HELA_Human0.93674579
106THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92948759
107PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.91201405
108SOX17_20123909_ChIP-Seq_XEN_Mouse0.90155665
109SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88811274
110NANOG_16518401_ChIP-PET_MESCs_Mouse0.88671422
111RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88658036
112HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88593940
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88111430
114POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.87765853
115TFEB_21752829_ChIP-Seq_HELA_Human0.87328764
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87171398
117PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86981396
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85846871
119CHD1_26751641_Chip-Seq_LNCaP_Human0.85779930
120CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85694865
121SOX2_16153702_ChIP-ChIP_HESCs_Human0.78611075
122BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78372384
123GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75948337
124CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.74793906
125* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.74628424
126TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.72565625
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.71164924
128CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70668326
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.66575528
130ZNF263_19887448_ChIP-Seq_K562_Human0.64928917
131TBX5_21415370_ChIP-Seq_HL-1_Mouse0.62746854
132PKCTHETA_26484144_Chip-Seq_BREAST_Human0.62533089
133HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.59474290
134FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.56251043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.44693676
2MP0004957_abnormal_blastocyst_morpholog3.88506309
3MP0010094_abnormal_chromosome_stability3.55863505
4MP0003111_abnormal_nucleus_morphology3.40977632
5MP0004264_abnormal_extraembryonic_tissu3.20190036
6MP0006292_abnormal_olfactory_placode3.20165507
7MP0003077_abnormal_cell_cycle3.15828208
8MP0003693_abnormal_embryo_hatching2.98250077
9MP0003890_abnormal_embryonic-extraembry2.93260684
10MP0010352_gastrointestinal_tract_polyps2.49668532
11MP0003121_genomic_imprinting2.48189086
12MP0000350_abnormal_cell_proliferation2.20893675
13MP0009697_abnormal_copulation2.20645816
14MP0008058_abnormal_DNA_repair2.17869312
15MP0005380_embryogenesis_phenotype2.14990971
16MP0001672_abnormal_embryogenesis/_devel2.14990971
17MP0002254_reproductive_system_inflammat2.13318149
18MP0003011_delayed_dark_adaptation2.12531631
19MP0005075_abnormal_melanosome_morpholog2.11373116
20MP0003123_paternal_imprinting2.10098477
21MP0005394_taste/olfaction_phenotype2.07964865
22MP0005499_abnormal_olfactory_system2.07964865
23MP0002396_abnormal_hematopoietic_system1.99670896
24MP0003984_embryonic_growth_retardation1.95391731
25MP0002653_abnormal_ependyma_morphology1.94822524
26MP0002088_abnormal_embryonic_growth/wei1.94222633
27MP0008007_abnormal_cellular_replicative1.91093687
28MP0008932_abnormal_embryonic_tissue1.86997689
29MP0003705_abnormal_hypodermis_morpholog1.83931994
30MP0001293_anophthalmia1.81915747
31MP0001730_embryonic_growth_arrest1.75187617
32MP0003122_maternal_imprinting1.73738641
33MP0002085_abnormal_embryonic_tissue1.70874240
34MP0005257_abnormal_intraocular_pressure1.70362643
35MP0002086_abnormal_extraembryonic_tissu1.68388404
36MP0003718_maternal_effect1.67358373
37MP0002084_abnormal_developmental_patter1.62390484
38MP0002009_preneoplasia1.58096278
39MP0000490_abnormal_crypts_of1.50963982
40MP0004197_abnormal_fetal_growth/weight/1.49892690
41MP0001697_abnormal_embryo_size1.48172442
42MP0009672_abnormal_birth_weight1.45918760
43MP0002877_abnormal_melanocyte_morpholog1.44518759
44MP0003787_abnormal_imprinting1.41212819
45MP0010030_abnormal_orbit_morphology1.40563430
46MP0002332_abnormal_exercise_endurance1.39969930
47MP0002277_abnormal_respiratory_mucosa1.39961112
48MP0010307_abnormal_tumor_latency1.36069806
49MP0000313_abnormal_cell_death1.34202354
50MP0002080_prenatal_lethality1.33509264
51MP0003786_premature_aging1.32186301
52MP0002092_abnormal_eye_morphology1.31876496
53MP0003938_abnormal_ear_development1.27460912
54MP0000678_abnormal_parathyroid_gland1.26932109
55MP0004858_abnormal_nervous_system1.26543523
56MP0006035_abnormal_mitochondrial_morpho1.20208744
57MP0001849_ear_inflammation1.19300157
58MP0004133_heterotaxia1.13661236
59MP0002127_abnormal_cardiovascular_syste1.10021707
60MP0003315_abnormal_perineum_morphology1.09594205
61MP0000432_abnormal_head_morphology1.08705531
62MP0000537_abnormal_urethra_morphology1.06755065
63MP0002019_abnormal_tumor_incidence1.06318038
64MP0003119_abnormal_digestive_system1.04826481
65MP0008789_abnormal_olfactory_epithelium1.04740325
66MP0008877_abnormal_DNA_methylation1.04094949
67MP0010234_abnormal_vibrissa_follicle1.03810591
68MP0003941_abnormal_skin_development1.03214188
69MP0002932_abnormal_joint_morphology1.03113852
70MP0004233_abnormal_muscle_weight1.01586818
71MP0002938_white_spotting1.01018131
72MP0000049_abnormal_middle_ear0.99754567
73MP0003567_abnormal_fetal_cardiomyocyte0.98231532
74MP0001346_abnormal_lacrimal_gland0.97361544
75MP0003937_abnormal_limbs/digits/tail_de0.97213320
76MP0000428_abnormal_craniofacial_morphol0.96614920
77MP0003935_abnormal_craniofacial_develop0.95309254
78MP0005076_abnormal_cell_differentiation0.95131409
79MP0000653_abnormal_sex_gland0.94034221
80MP0002114_abnormal_axial_skeleton0.92217378
81MP0002233_abnormal_nose_morphology0.91723590
82MP0000372_irregular_coat_pigmentation0.91642881
83MP0001661_extended_life_span0.91171518
84MP0008995_early_reproductive_senescence0.90739927
85MP0009703_decreased_birth_body0.90729123
86MP0001145_abnormal_male_reproductive0.90182909
87MP0004808_abnormal_hematopoietic_stem0.89348558
88MP0003755_abnormal_palate_morphology0.89313753
89MP0002210_abnormal_sex_determination0.88102761
90MP0005266_abnormal_metabolism0.87959666
91MP0001286_abnormal_eye_development0.86856497
92MP0003283_abnormal_digestive_organ0.85494952
93MP0004185_abnormal_adipocyte_glucose0.85474991
94MP0003136_yellow_coat_color0.85026400
95MP0003806_abnormal_nucleotide_metabolis0.84996728
96MP0005171_absent_coat_pigmentation0.84571202
97MP0002160_abnormal_reproductive_system0.83653664
98MP0002925_abnormal_cardiovascular_devel0.82874251
99MP0002111_abnormal_tail_morphology0.82076814
100MP0003943_abnormal_hepatobiliary_system0.81930137
101MP0008770_decreased_survivor_rate0.81266189
102MP0000566_synostosis0.80099829
103MP0000762_abnormal_tongue_morphology0.79504576
104MP0005023_abnormal_wound_healing0.78516308
105MP0005408_hypopigmentation0.77664136
106MP0002234_abnormal_pharynx_morphology0.77127751
107MP0005384_cellular_phenotype0.76775548
108MP0001119_abnormal_female_reproductive0.76191393
109MP0005391_vision/eye_phenotype0.72956119
110MP0002249_abnormal_larynx_morphology0.72838135
111MP0003698_abnormal_male_reproductive0.72550805
112MP0003699_abnormal_female_reproductive0.72148762
113MP0000703_abnormal_thymus_morphology0.72126399
114MP0002697_abnormal_eye_size0.71746965
115MP0005501_abnormal_skin_physiology0.71057170
116MP0002722_abnormal_immune_system0.70971982
117MP0001929_abnormal_gametogenesis0.70050186
118MP0002970_abnormal_white_adipose0.69436521
119MP0000689_abnormal_spleen_morphology0.68657265
120MP0006082_CNS_inflammation0.68055770
121MP0002075_abnormal_coat/hair_pigmentati0.67850502
122MP0002161_abnormal_fertility/fecundity0.67504383
123MP0002116_abnormal_craniofacial_bone0.66541778
124MP0003385_abnormal_body_wall0.65994335
125MP0004147_increased_porphyrin_level0.65944521
126MP0005621_abnormal_cell_physiology0.65905820
127MP0003861_abnormal_nervous_system0.65692377
128MP0002095_abnormal_skin_pigmentation0.63649972
129MP0003566_abnormal_cell_adhesion0.63003900
130MP0003448_altered_tumor_morphology0.62487165
131MP0000858_altered_metastatic_potential0.61911219
132MP0000358_abnormal_cell_content/0.61850505
133MP0003942_abnormal_urinary_system0.59228193
134MP0003221_abnormal_cardiomyocyte_apopto0.55460062
135MP0003115_abnormal_respiratory_system0.55062071
136MP0006036_abnormal_mitochondrial_physio0.54991943
137MP0000579_abnormal_nail_morphology0.53915672
138MP0001881_abnormal_mammary_gland0.53111260
139MP0001186_pigmentation_phenotype0.52989574

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.41926375
2Hypochromic microcytic anemia (HP:0004840)5.01205186
3Ependymoma (HP:0002888)4.94970533
4Rib fusion (HP:0000902)4.18192049
5Rhabdomyosarcoma (HP:0002859)4.04214837
6Nephroblastoma (Wilms tumor) (HP:0002667)3.82727981
7Reticulocytopenia (HP:0001896)3.73827349
8Neoplasm of striated muscle (HP:0009728)3.73115124
9* Abnormality of the preputium (HP:0100587)3.70702113
10Multiple enchondromatosis (HP:0005701)3.68636978
11Astrocytoma (HP:0009592)3.57714732
12Abnormality of the astrocytes (HP:0100707)3.57714732
13Abnormality of the lower motor neuron (HP:0002366)3.54804065
14Embryonal renal neoplasm (HP:0011794)3.54430433
15Hepatoblastoma (HP:0002884)3.47849583
16Impulsivity (HP:0100710)3.35772775
17Abnormal lung lobation (HP:0002101)3.18197131
18Supernumerary spleens (HP:0009799)3.12884961
19Medulloblastoma (HP:0002885)3.11955756
20Aplasia/hypoplasia of the humerus (HP:0006507)3.09183109
21Short humerus (HP:0005792)2.98135582
22Rectal fistula (HP:0100590)2.97678734
23Rectovaginal fistula (HP:0000143)2.97678734
24* Abnormality of the carotid arteries (HP:0005344)2.89355767
25Glioma (HP:0009733)2.82310395
26Intestinal fistula (HP:0100819)2.77995100
27Abnormality of cochlea (HP:0000375)2.69198233
28Cortical dysplasia (HP:0002539)2.68782286
29Volvulus (HP:0002580)2.65915315
30Aplasia/Hypoplasia of the sacrum (HP:0008517)2.65491339
31Microvesicular hepatic steatosis (HP:0001414)2.65247720
32Fused cervical vertebrae (HP:0002949)2.64567864
33Duplicated collecting system (HP:0000081)2.62262307
34Colon cancer (HP:0003003)2.62220051
35* Cafe-au-lait spot (HP:0000957)2.61634600
36Abnormality of the salivary glands (HP:0010286)2.57797012
37Abnormality of chromosome segregation (HP:0002916)2.56049622
38Selective tooth agenesis (HP:0001592)2.51099790
39* Meckel diverticulum (HP:0002245)2.50358335
40Shawl scrotum (HP:0000049)2.50271111
41* Chromosomal breakage induced by crosslinking agents (HP:0003221)2.49272403
42Hypoplasia of the fovea (HP:0007750)2.49022099
43Aplasia/Hypoplasia of the fovea (HP:0008060)2.49022099
44Abnormality of the labia minora (HP:0012880)2.47697806
45Aplasia/Hypoplasia of the sternum (HP:0006714)2.47567069
46* Chromsome breakage (HP:0040012)2.44255535
47Preauricular skin tag (HP:0000384)2.41647980
48Trismus (HP:0000211)2.39690107
49Neoplasm of the oral cavity (HP:0100649)2.39106009
50Vaginal fistula (HP:0004320)2.38329667
51Proximal placement of thumb (HP:0009623)2.38165262
52Large earlobe (HP:0009748)2.36988702
53* Abnormality of the ileum (HP:0001549)2.36965262
54* Aplasia/Hypoplasia of the uvula (HP:0010293)2.33676233
55Horseshoe kidney (HP:0000085)2.31671976
56Absent thumb (HP:0009777)2.30458463
57Short thumb (HP:0009778)2.29520237
58Abnormality of DNA repair (HP:0003254)2.29464545
59Abnormality of glycolysis (HP:0004366)2.28087740
60Squamous cell carcinoma (HP:0002860)2.26518031
61High anterior hairline (HP:0009890)2.26099232
62Bifid tongue (HP:0010297)2.25867543
63Missing ribs (HP:0000921)2.24358161
64* Small intestinal stenosis (HP:0012848)2.24183123
65* Duodenal stenosis (HP:0100867)2.24183123
66Deviation of the thumb (HP:0009603)2.23158978
67Increased nuchal translucency (HP:0010880)2.22408642
68Skin tags (HP:0010609)2.21508138
69Deep philtrum (HP:0002002)2.21364704
70Atresia of the external auditory canal (HP:0000413)2.21089095
71Birth length less than 3rd percentile (HP:0003561)2.20848646
72Patellar aplasia (HP:0006443)2.19928560
73Hypochromic anemia (HP:0001931)2.19926138
74Partial duplication of thumb phalanx (HP:0009944)2.19651106
75* Triphalangeal thumb (HP:0001199)2.19443276
76Spinal muscular atrophy (HP:0007269)2.18989614
77Absent radius (HP:0003974)2.18936667
78Overlapping toe (HP:0001845)2.18439196
79Abnormality of the renal collecting system (HP:0004742)2.18043732
80* Clubbing of toes (HP:0100760)2.17089830
81* Sloping forehead (HP:0000340)2.14285177
82* Myelodysplasia (HP:0002863)2.10996150
83Amyotrophic lateral sclerosis (HP:0007354)2.08989436
84* Choanal atresia (HP:0000453)2.08778222
85Abnormality of the phalanges of the hallux (HP:0010057)2.08262565
86Premature ovarian failure (HP:0008209)2.08215516
87Prominent nose (HP:0000448)2.07796400
88Breast hypoplasia (HP:0003187)2.07647148
89Duplication of thumb phalanx (HP:0009942)2.07451860
90Testicular atrophy (HP:0000029)2.06888349
91High pitched voice (HP:0001620)2.06040006
92Abnormal number of incisors (HP:0011064)2.05783958
93Supernumerary ribs (HP:0005815)2.03578957
94Hypopigmentation of the fundus (HP:0007894)2.03310304
95Horizontal nystagmus (HP:0000666)2.02304267
96Combined immunodeficiency (HP:0005387)2.01599300
97Absent forearm bone (HP:0003953)2.01073429
98Aplasia involving forearm bones (HP:0009822)2.01073429
99Ectopic kidney (HP:0000086)2.00601543
100Facial cleft (HP:0002006)2.00451107
101Morphological abnormality of the inner ear (HP:0011390)1.99448192
102Neoplasm of the colon (HP:0100273)1.98869344
103* Abnormality of chromosome stability (HP:0003220)1.98431082
104Agnosia (HP:0010524)1.98196602
105Atrophy/Degeneration involving motor neurons (HP:0007373)1.97565228
106Aplasia/Hypoplasia of the patella (HP:0006498)1.96569821
107Renal duplication (HP:0000075)1.96392335
108Pendular nystagmus (HP:0012043)1.96327940
109* Arteriovenous malformation (HP:0100026)1.95750855
110Hypoplasia of the capital femoral epiphysis (HP:0003090)1.95606824
111Glossoptosis (HP:0000162)1.95271347
112Progressive external ophthalmoplegia (HP:0000590)1.95243284
113Progressive muscle weakness (HP:0003323)1.94407944
114Supernumerary bones of the axial skeleton (HP:0009144)1.94186511
115Partial duplication of the phalanx of hand (HP:0009999)1.93213004
116Short 5th finger (HP:0009237)1.90437206
117Pseudobulbar signs (HP:0002200)1.90112848
118Facial hemangioma (HP:0000329)1.89709216
119Embryonal neoplasm (HP:0002898)1.89005370
120Increased serum pyruvate (HP:0003542)1.88956228
121Abnormality of the distal phalanx of the thumb (HP:0009617)1.88815945
122Malignant neoplasm of the central nervous system (HP:0100836)1.88084267
123Tongue fasciculations (HP:0001308)1.88022774
124Reduced antithrombin III activity (HP:0001976)1.87410020
125Ragged-red muscle fibers (HP:0003200)1.86818089
126Vertebral fusion (HP:0002948)1.85572384
127Abnormality of the anterior horn cell (HP:0006802)1.85397944
128Degeneration of anterior horn cells (HP:0002398)1.85397944
129* Abnormality of the duodenum (HP:0002246)1.84295128
130Upper motor neuron abnormality (HP:0002127)1.83476945
131Preauricular pit (HP:0004467)1.82572872
132Periauricular skin pits (HP:0100277)1.82572872
133Microretrognathia (HP:0000308)1.81911659
134Anomalous pulmonary venous return (HP:0010772)1.81807217
135Poikiloderma (HP:0001029)1.80974480
136Abnormality of reticulocytes (HP:0004312)1.79858278
137Absent epiphyses (HP:0010577)1.75593004
138Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75593004
139Cholecystitis (HP:0001082)1.72412805
140Abnormal gallbladder physiology (HP:0012438)1.72412805
141Aplasia/Hypoplasia of the earlobes (HP:0009906)1.72121768
14211 pairs of ribs (HP:0000878)1.72016388
143Sandal gap (HP:0001852)1.70487716
144Irregular epiphyses (HP:0010582)1.68940284
145Secondary amenorrhea (HP:0000869)1.65857999
146Pancytopenia (HP:0001876)1.62688208
147Carpal bone hypoplasia (HP:0001498)1.62624867
148Single umbilical artery (HP:0001195)1.61035496
149Abnormality of the fetal cardiovascular system (HP:0010948)1.61035496
150Abnormal umbilical cord blood vessels (HP:0011403)1.61035496
151Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.60892344
152Obsessive-compulsive behavior (HP:0000722)1.60402345
153Abnormality of the calcaneus (HP:0008364)1.59983314
154Cutaneous melanoma (HP:0012056)1.59475779
155Microglossia (HP:0000171)1.59225566
156Pallor (HP:0000980)1.58461407
157Septate vagina (HP:0001153)1.57686247

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.16687750
2TTK3.48660156
3CDC73.13687703
4GRK53.06751301
5GRK62.88688212
6WEE12.71652000
7STK102.49145075
8ERN12.46301882
9PBK2.44218511
10NEK22.32911381
11BUB12.27682845
12CSF1R2.22307286
13CDK72.19107375
14ADRBK22.09979595
15VRK22.09322214
16EPHA22.01205609
17PLK12.00630919
18CHEK21.97660291
19TGFBR21.97646692
20SMG11.80805276
21GRK11.80313300
22TAF11.68546363
23MATK1.63413368
24SRPK11.58684023
25TYRO31.56352342
26MAPK71.52010147
27NEK11.48662792
28GRK71.44422033
29AKT31.42566758
30PNCK1.42268053
31CHEK11.39868361
32PAK41.35768463
33RPS6KB21.32196589
34AURKB1.31045455
35MAP3K101.27524155
36CDK41.21881938
37ATR1.19863744
38MOS1.16940552
39NME21.12955311
40WNK11.08154676
41BRSK21.01888978
42ACVR1B1.01631431
43STK40.96412620
44CAMK40.95236820
45ALK0.93715250
46CDK20.91997324
47AURKA0.91457222
48CLK10.88070200
49BRD40.86607111
50* ATM0.84112300
51EIF2AK20.83574662
52AKT20.82555593
53TRIM280.82029433
54BRAF0.81492469
55PRKG20.79686740
56EEF2K0.79384678
57NUAK10.79377703
58MST1R0.78155628
59MTOR0.74900256
60BRSK10.74800071
61MAP3K80.71912385
62PLK40.68870877
63NME10.68595276
64DYRK30.68229674
65VRK10.66941572
66MST40.66068856
67PASK0.65803554
68PLK30.65759703
69STK30.65466213
70CDK10.65191703
71STK160.64777181
72FGFR30.64297596
73MKNK10.64262551
74MELK0.64254137
75TLK10.64248315
76ZAK0.64108678
77CAMK1G0.62246584
78MKNK20.61055811
79EIF2AK10.60093177
80MARK20.59665186
81PDK20.58089567
82PIM10.57919920
83CSK0.53650895
84HIPK20.53461631
85ADRBK10.53067113
86PRKDC0.50436313
87CDK30.49891029
88IRAK30.49779033
89TSSK60.49066553
90YES10.48934392
91PRKCI0.48181670
92CDK90.47823497
93TRIB30.47248604
94ICK0.46989865
95CDK60.46604485
96LATS20.46116984
97CDK180.45931225
98PLK20.45181293
99CDK150.44959845
100CDK11A0.44102064
101MAPKAPK50.43974301
102PAK10.41529729
103MET0.41474433
104MAPK140.40959157
105LATS10.40201101
106CDK80.40185075
107FLT30.40064924
108MAP2K60.38075647
109TESK20.37744629
110PKN20.37634648
111CAMK1D0.37083341
112CDK140.36165790
113CSNK1E0.35962209
114FGFR10.35645174
115BMPR1B0.34225689
116GSK3B0.32872722
117MAPK10.32472253
118ERBB40.32183865
119ITK0.32062954
120SCYL20.31838172
121RAF10.31277862
122CHUK0.29911210
123MAPKAPK30.29262455
124STK38L0.28462766
125CSNK1D0.27693720
126EIF2AK30.27428324
127RPS6KA40.27141786
128MARK30.26929756
129CCNB10.26407430
130CSNK2A20.25733911
131MAP3K70.25620859
132AKT10.25563306
133MAPK110.25113427
134MAPK100.24650020
135CSNK2A10.24319007
136BCR0.24136760
137TGFBR10.23606078
138MAP2K40.23370002
139KSR10.22451729
140NEK90.22067327
141DAPK10.21673888
142IKBKB0.20144693

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.34818832
2DNA replication_Homo sapiens_hsa030304.21924171
3Mismatch repair_Homo sapiens_hsa034303.81088747
4Vitamin B6 metabolism_Homo sapiens_hsa007503.24045331
5RNA transport_Homo sapiens_hsa030133.05051621
6Homologous recombination_Homo sapiens_hsa034402.92460293
7Cell cycle_Homo sapiens_hsa041102.88140287
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.74058228
9Base excision repair_Homo sapiens_hsa034102.67661036
10One carbon pool by folate_Homo sapiens_hsa006702.67127773
11Spliceosome_Homo sapiens_hsa030402.52482522
12* Fanconi anemia pathway_Homo sapiens_hsa034602.35893345
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.30062581
14Nucleotide excision repair_Homo sapiens_hsa034202.20691455
15mRNA surveillance pathway_Homo sapiens_hsa030152.20260184
16Non-homologous end-joining_Homo sapiens_hsa034501.83970070
17RNA degradation_Homo sapiens_hsa030181.81904906
18Fructose and mannose metabolism_Homo sapiens_hsa000511.78573080
19p53 signaling pathway_Homo sapiens_hsa041151.78058283
20RNA polymerase_Homo sapiens_hsa030201.76264199
21Basal transcription factors_Homo sapiens_hsa030221.62500600
22Ribosome_Homo sapiens_hsa030101.56175160
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46625733
24Pyrimidine metabolism_Homo sapiens_hsa002401.45721302
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.34342404
26Systemic lupus erythematosus_Homo sapiens_hsa053221.22480339
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22108677
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19475128
29MicroRNAs in cancer_Homo sapiens_hsa052061.16113582
30Arachidonic acid metabolism_Homo sapiens_hsa005901.15288165
31Viral carcinogenesis_Homo sapiens_hsa052031.13423968
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13348446
33Herpes simplex infection_Homo sapiens_hsa051681.12458663
34Pyruvate metabolism_Homo sapiens_hsa006201.10397350
35Thyroid cancer_Homo sapiens_hsa052161.09834711
36Galactose metabolism_Homo sapiens_hsa000521.08476833
37Carbon metabolism_Homo sapiens_hsa012001.07925836
38mTOR signaling pathway_Homo sapiens_hsa041501.06058250
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05707077
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98483697
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92940885
42Protein export_Homo sapiens_hsa030600.88131997
43Basal cell carcinoma_Homo sapiens_hsa052170.86447581
44HTLV-I infection_Homo sapiens_hsa051660.86016456
45Linoleic acid metabolism_Homo sapiens_hsa005910.78071748
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76494334
47Notch signaling pathway_Homo sapiens_hsa043300.76113676
48Small cell lung cancer_Homo sapiens_hsa052220.76070150
49Oocyte meiosis_Homo sapiens_hsa041140.74936757
50Hippo signaling pathway_Homo sapiens_hsa043900.73997799
51Epstein-Barr virus infection_Homo sapiens_hsa051690.71420201
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71155325
53N-Glycan biosynthesis_Homo sapiens_hsa005100.69800527
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69150837
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68193693
56Propanoate metabolism_Homo sapiens_hsa006400.65728763
57Pathways in cancer_Homo sapiens_hsa052000.65640086
58Proteasome_Homo sapiens_hsa030500.64673817
59Colorectal cancer_Homo sapiens_hsa052100.64413800
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.64133112
61Primary immunodeficiency_Homo sapiens_hsa053400.61279758
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60248815
63Apoptosis_Homo sapiens_hsa042100.60186514
64Steroid biosynthesis_Homo sapiens_hsa001000.59973549
65Purine metabolism_Homo sapiens_hsa002300.59108442
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58877019
67Antigen processing and presentation_Homo sapiens_hsa046120.56463074
68Hedgehog signaling pathway_Homo sapiens_hsa043400.56090598
69Pentose phosphate pathway_Homo sapiens_hsa000300.55836092
70Adherens junction_Homo sapiens_hsa045200.55688097
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55578372
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.54812765
73Fatty acid elongation_Homo sapiens_hsa000620.54654175
74Selenocompound metabolism_Homo sapiens_hsa004500.53213595
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52985394
76Acute myeloid leukemia_Homo sapiens_hsa052210.52634025
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52296154
78Non-small cell lung cancer_Homo sapiens_hsa052230.50054173
79Sulfur relay system_Homo sapiens_hsa041220.49838188
80TGF-beta signaling pathway_Homo sapiens_hsa043500.48399425
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47619824
82Biosynthesis of amino acids_Homo sapiens_hsa012300.47317170
83Inositol phosphate metabolism_Homo sapiens_hsa005620.47152049
84Glutathione metabolism_Homo sapiens_hsa004800.46445222
85Bladder cancer_Homo sapiens_hsa052190.45018818
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44936942
87Alcoholism_Homo sapiens_hsa050340.43134255
88Huntingtons disease_Homo sapiens_hsa050160.42998479
89Lysine degradation_Homo sapiens_hsa003100.42931588
90Pancreatic cancer_Homo sapiens_hsa052120.42562772
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41406111
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41329062
93Wnt signaling pathway_Homo sapiens_hsa043100.40376690
94Folate biosynthesis_Homo sapiens_hsa007900.40149703
95Influenza A_Homo sapiens_hsa051640.39816988
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39258037
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36544288
98Legionellosis_Homo sapiens_hsa051340.35906410
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35846605
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35765417
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35668119
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32667437
103Measles_Homo sapiens_hsa051620.32285710
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32117808
105Chronic myeloid leukemia_Homo sapiens_hsa052200.31005191
106Proteoglycans in cancer_Homo sapiens_hsa052050.30880236
107Hepatitis B_Homo sapiens_hsa051610.30029455
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.29876874
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.29852026
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29354920
111Other glycan degradation_Homo sapiens_hsa005110.29030140
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28566298
113Metabolic pathways_Homo sapiens_hsa011000.28088554
114Melanoma_Homo sapiens_hsa052180.27611057
115Fatty acid metabolism_Homo sapiens_hsa012120.26788105
116Hematopoietic cell lineage_Homo sapiens_hsa046400.26648926
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.26420851
118Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26365381
119Parkinsons disease_Homo sapiens_hsa050120.26167907
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25307971
121Rap1 signaling pathway_Homo sapiens_hsa040150.23152964
122T cell receptor signaling pathway_Homo sapiens_hsa046600.22699375
123B cell receptor signaling pathway_Homo sapiens_hsa046620.21921382
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.21913316
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21306223
126Glioma_Homo sapiens_hsa052140.21243157
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.20906018
128Tight junction_Homo sapiens_hsa045300.20727590
129Leishmaniasis_Homo sapiens_hsa051400.19512917
130Prostate cancer_Homo sapiens_hsa052150.18459263
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18154591
132Endometrial cancer_Homo sapiens_hsa052130.17660625
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.16545250
134Arginine and proline metabolism_Homo sapiens_hsa003300.12370440
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12304186

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »