FANCM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.32651228
2nuclear pore complex assembly (GO:0051292)5.31357489
3protein localization to kinetochore (GO:0034501)5.08096698
4mitotic metaphase plate congression (GO:0007080)5.02689117
5DNA replication checkpoint (GO:0000076)4.83533227
6DNA replication initiation (GO:0006270)4.66334268
7centriole replication (GO:0007099)4.42759073
8metaphase plate congression (GO:0051310)4.40478733
9protein localization to chromosome, centromeric region (GO:0071459)4.35238040
10mitotic nuclear envelope disassembly (GO:0007077)4.30240414
11DNA replication-dependent nucleosome assembly (GO:0006335)4.28976247
12DNA replication-dependent nucleosome organization (GO:0034723)4.28976247
13mitotic sister chromatid segregation (GO:0000070)4.24728940
14nucleobase biosynthetic process (GO:0046112)4.24643101
15regulation of spindle organization (GO:0090224)4.23408968
16purine nucleobase biosynthetic process (GO:0009113)4.21806720
17DNA unwinding involved in DNA replication (GO:0006268)4.14003123
18mitotic chromosome condensation (GO:0007076)4.13604019
19* replication fork processing (GO:0031297)4.12457674
20kinetochore organization (GO:0051383)4.11592195
21DNA strand elongation involved in DNA replication (GO:0006271)4.08360505
22pore complex assembly (GO:0046931)4.07967920
23sister chromatid segregation (GO:0000819)4.02964753
24regulation of DNA endoreduplication (GO:0032875)4.02494278
25membrane disassembly (GO:0030397)4.01946109
26nuclear envelope disassembly (GO:0051081)4.01946109
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.99495948
28regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.97575903
29positive regulation of chromosome segregation (GO:0051984)3.91013617
30DNA strand elongation (GO:0022616)3.89621931
31ribosome assembly (GO:0042255)3.87343544
32regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.86651519
33regulation of mitotic spindle checkpoint (GO:1903504)3.86651519
34protein K6-linked ubiquitination (GO:0085020)3.81541655
35chromatin remodeling at centromere (GO:0031055)3.79951005
36somatic hypermutation of immunoglobulin genes (GO:0016446)3.78886765
37somatic diversification of immune receptors via somatic mutation (GO:0002566)3.78886765
38CENP-A containing nucleosome assembly (GO:0034080)3.77995143
39regulation of mitotic spindle organization (GO:0060236)3.77652887
40kinetochore assembly (GO:0051382)3.76826977
41telomere maintenance via semi-conservative replication (GO:0032201)3.74406356
42non-recombinational repair (GO:0000726)3.74156134
43double-strand break repair via nonhomologous end joining (GO:0006303)3.74156134
44establishment of chromosome localization (GO:0051303)3.70855828
45DNA replication-independent nucleosome organization (GO:0034724)3.70193955
46DNA replication-independent nucleosome assembly (GO:0006336)3.70193955
47mitotic G2/M transition checkpoint (GO:0044818)3.69530780
48mitotic sister chromatid cohesion (GO:0007064)3.69388613
49regulation of telomere maintenance via telomerase (GO:0032210)3.65620421
50negative regulation of histone methylation (GO:0031061)3.64662712
51spindle checkpoint (GO:0031577)3.62580464
52mitotic recombination (GO:0006312)3.58300735
53telomere maintenance via recombination (GO:0000722)3.58131973
54attachment of spindle microtubules to kinetochore (GO:0008608)3.57829303
55regulation of chromosome segregation (GO:0051983)3.57658498
56DNA topological change (GO:0006265)3.56978532
57regulation of nuclear cell cycle DNA replication (GO:0033262)3.56441204
58regulation of histone H3-K9 methylation (GO:0051570)3.56422737
59DNA ligation (GO:0006266)3.55509150
60regulation of RNA export from nucleus (GO:0046831)3.54917648
61regulation of mitotic metaphase/anaphase transition (GO:0030071)3.53718262
62negative regulation of chromosome segregation (GO:0051985)3.53627775
63DNA geometric change (GO:0032392)3.53469451
64DNA duplex unwinding (GO:0032508)3.52701628
65recombinational repair (GO:0000725)3.52146938
66positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.50483896
67positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.50483896
68positive regulation of mitotic sister chromatid separation (GO:1901970)3.50483896
69regulation of sister chromatid cohesion (GO:0007063)3.50150472
70IMP biosynthetic process (GO:0006188)3.49359392
71double-strand break repair via homologous recombination (GO:0000724)3.48877447
72protein localization to chromosome (GO:0034502)3.48691036
73spindle assembly checkpoint (GO:0071173)3.48305844
74regulation of centrosome cycle (GO:0046605)3.47125725
75regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.46961825
76negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.45472857
77negative regulation of sister chromatid segregation (GO:0033046)3.45472857
78negative regulation of mitotic sister chromatid separation (GO:2000816)3.45472857
79negative regulation of mitotic sister chromatid segregation (GO:0033048)3.45472857
80synapsis (GO:0007129)3.44966611
81histone exchange (GO:0043486)3.43316573
82regulation of centrosome duplication (GO:0010824)3.42610768
83sister chromatid cohesion (GO:0007062)3.42488358
84regulation of helicase activity (GO:0051095)3.42271784
85microtubule depolymerization (GO:0007019)3.41802503
86meiotic chromosome segregation (GO:0045132)3.40662598
87mitotic spindle assembly checkpoint (GO:0007094)3.40579444
88mitotic spindle checkpoint (GO:0071174)3.40082163
89ribosome biogenesis (GO:0042254)3.39243252
90regulation of double-strand break repair via homologous recombination (GO:0010569)3.38513861
91negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.36971744
92DNA catabolic process, exonucleolytic (GO:0000738)3.36472747
93regulation of mitotic sister chromatid separation (GO:0010965)3.35737035
94regulation of mitotic sister chromatid segregation (GO:0033047)3.35737035
95regulation of sister chromatid segregation (GO:0033045)3.35737035
96negative regulation of DNA recombination (GO:0045910)3.33671534
97chromatin assembly or disassembly (GO:0006333)3.31515958
98telomere maintenance via telomere lengthening (GO:0010833)3.28754072
99pre-miRNA processing (GO:0031054)3.27355471
100telomere maintenance (GO:0000723)3.27288080
101folic acid-containing compound biosynthetic process (GO:0009396)3.25793091
102telomere organization (GO:0032200)3.24650566
103* maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.23512199
104chromosome segregation (GO:0007059)3.22827120
105nucleotide-excision repair, DNA gap filling (GO:0006297)3.20476992
106DNA-dependent DNA replication (GO:0006261)3.20354416
107regulation of meiosis I (GO:0060631)3.19982349
108response to X-ray (GO:0010165)3.18671938
109regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.18177318
110nuclear envelope organization (GO:0006998)3.16842881
111regulation of centriole replication (GO:0046599)3.14758811
112formation of translation preinitiation complex (GO:0001731)3.12308817
113double-strand break repair (GO:0006302)3.10934698
114RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.09045501
115negative regulation of DNA-dependent DNA replication (GO:2000104)3.08407133
116histone H2A monoubiquitination (GO:0035518)3.07057806
117regulation of double-strand break repair (GO:2000779)3.06951070
118mismatch repair (GO:0006298)3.04793335
119regulation of spindle checkpoint (GO:0090231)3.04590430
120ATP-dependent chromatin remodeling (GO:0043044)3.03501429
121translesion synthesis (GO:0019985)3.01690849
122DNA conformation change (GO:0071103)3.01622288
123IMP metabolic process (GO:0046040)2.99172835
124chromatin assembly (GO:0031497)2.98484292
125postreplication repair (GO:0006301)2.97327535
126DNA double-strand break processing (GO:0000729)2.89536808

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.41813195
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.42608168
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.67448312
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.46211154
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.85325404
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.85192838
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65868143
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.54045961
9AR_21909140_ChIP-Seq_LNCAP_Human2.51883408
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49928944
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.44976801
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.41778620
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.40760991
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36425186
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31826644
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30307112
17* EST1_17652178_ChIP-ChIP_JURKAT_Human2.24760965
18EWS_26573619_Chip-Seq_HEK293_Human2.24143281
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19971311
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.18737083
21FUS_26573619_Chip-Seq_HEK293_Human2.18095003
22* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.15389524
23NANOG_18555785_ChIP-Seq_MESCs_Mouse2.11508494
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10564672
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.08378047
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.05131436
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.03860985
28MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02732226
29TP63_19390658_ChIP-ChIP_HaCaT_Human2.01839306
30E2F7_22180533_ChIP-Seq_HELA_Human10.7046709
31* GABP_17652178_ChIP-ChIP_JURKAT_Human1.97551061
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.97256183
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96754735
34XRN2_22483619_ChIP-Seq_HELA_Human1.92633430
35* VDR_23849224_ChIP-Seq_CD4+_Human1.85532472
36ZNF274_21170338_ChIP-Seq_K562_Hela1.81462999
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76878095
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74030299
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.73440499
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69545418
41* FOXP3_21729870_ChIP-Seq_TREG_Human1.66320586
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63425248
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62955764
44* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62562200
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60735985
46KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60735985
47KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60735985
48MYC_18940864_ChIP-ChIP_HL60_Human1.58239064
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57859804
50KDM5A_27292631_Chip-Seq_BREAST_Human1.55304044
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54278008
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53830387
53TAF15_26573619_Chip-Seq_HEK293_Human1.52838348
54IRF1_19129219_ChIP-ChIP_H3396_Human1.52306829
55CIITA_25753668_ChIP-Seq_RAJI_Human1.52230031
56GABP_19822575_ChIP-Seq_HepG2_Human1.51294578
57TTF2_22483619_ChIP-Seq_HELA_Human1.47437987
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47407376
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46744818
60DCP1A_22483619_ChIP-Seq_HELA_Human1.46124619
61MYC_22102868_ChIP-Seq_BL_Human1.43771177
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.41458316
63VDR_22108803_ChIP-Seq_LS180_Human1.39502128
64NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.38337954
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35555568
66* ELK1_19687146_ChIP-ChIP_HELA_Human1.33424257
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32165309
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30745696
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29705391
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29589602
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.29504608
72TCF3_18692474_ChIP-Seq_MESCs_Mouse1.28435993
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27842215
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27384720
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27235397
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27145846
77P300_19829295_ChIP-Seq_ESCs_Human1.25884267
78* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24876589
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.24118462
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22599567
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.21728667
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21215389
83SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20094201
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.19788153
85CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18679568
86IGF1R_20145208_ChIP-Seq_DFB_Human1.18658601
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17774768
88HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16153081
89GBX2_23144817_ChIP-Seq_PC3_Human1.11220944
90* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10218250
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09845454
92ER_23166858_ChIP-Seq_MCF-7_Human1.09765062
93* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06216703
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06088652
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05487011
96NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.05019486
97SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.03682597
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03156781
99* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02913743
100* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02604771
101* CBP_20019798_ChIP-Seq_JUKART_Human1.02604771
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02092091
103TFEB_21752829_ChIP-Seq_HELA_Human1.01676339
104ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00478664
105NANOG_16153702_ChIP-ChIP_HESCs_Human1.00280586
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.00178884
107SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00161314
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00089055
109SOX2_16153702_ChIP-ChIP_HESCs_Human0.98457832
110CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97472058
111PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97284619
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96743418
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96218042
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96203335
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95998655
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95594315
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94164849
118SRF_21415370_ChIP-Seq_HL-1_Mouse0.93159067
119NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93125568
120SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91750966
121* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91517294
122ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91510330
123* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90382350
124ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90207951
125SOX2_18692474_ChIP-Seq_MESCs_Mouse0.86288096
126CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86024072
127PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85425569
128STAT3_23295773_ChIP-Seq_U87_Human0.84266155
129NOTCH1_21737748_ChIP-Seq_TLL_Human0.84246977
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83411634
131SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82955482
132RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.82197472
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80594972
134POU5F1_16153702_ChIP-ChIP_HESCs_Human0.80303785
135POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.80255363
136OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79337674
137SOX9_26525672_Chip-Seq_HEART_Mouse0.78526309
138SMAD4_21799915_ChIP-Seq_A2780_Human0.78105972
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78002856
140FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77046375
141SMAD3_21741376_ChIP-Seq_EPCs_Human0.76989657
142TOP2B_26459242_ChIP-Seq_MCF-7_Human0.76476178
143PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.76292890

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.05335657
2MP0010094_abnormal_chromosome_stability4.83130513
3MP0008057_abnormal_DNA_replication4.81605854
4MP0003111_abnormal_nucleus_morphology4.77201122
5MP0004957_abnormal_blastocyst_morpholog4.15285878
6* MP0003077_abnormal_cell_cycle3.90445656
7MP0008058_abnormal_DNA_repair3.31968833
8MP0009697_abnormal_copulation2.74493484
9MP0008007_abnormal_cellular_replicative2.66750193
10MP0008877_abnormal_DNA_methylation2.58369629
11MP0003123_paternal_imprinting2.57147494
12MP0001730_embryonic_growth_arrest2.56657099
13MP0008932_abnormal_embryonic_tissue2.52942923
14MP0010307_abnormal_tumor_latency2.49079351
15MP0000350_abnormal_cell_proliferation2.49071990
16MP0010352_gastrointestinal_tract_polyps2.40705123
17MP0001672_abnormal_embryogenesis/_devel2.18330836
18MP0005380_embryogenesis_phenotype2.18330836
19MP0003121_genomic_imprinting2.08971771
20MP0003890_abnormal_embryonic-extraembry1.99745508
21MP0002084_abnormal_developmental_patter1.94455587
22MP0003984_embryonic_growth_retardation1.94417400
23MP0001697_abnormal_embryo_size1.93938213
24MP0002085_abnormal_embryonic_tissue1.91968500
25MP0002088_abnormal_embryonic_growth/wei1.90077847
26MP0003786_premature_aging1.80130294
27MP0003718_maternal_effect1.74612545
28MP0002086_abnormal_extraembryonic_tissu1.74304209
29MP0010030_abnormal_orbit_morphology1.66882446
30MP0005076_abnormal_cell_differentiation1.66396871
31MP0002396_abnormal_hematopoietic_system1.66387397
32MP0002080_prenatal_lethality1.66094637
33MP0001293_anophthalmia1.61886954
34MP0004197_abnormal_fetal_growth/weight/1.60899274
35MP0002234_abnormal_pharynx_morphology1.57005870
36MP0002009_preneoplasia1.55148178
37MP0001529_abnormal_vocalization1.46113704
38MP0003937_abnormal_limbs/digits/tail_de1.42104590
39MP0002653_abnormal_ependyma_morphology1.41502491
40MP0003567_abnormal_fetal_cardiomyocyte1.39537962
41MP0008789_abnormal_olfactory_epithelium1.31332457
42MP0004264_abnormal_extraembryonic_tissu1.31172640
43MP0000313_abnormal_cell_death1.29487145
44MP0003119_abnormal_digestive_system1.27310009
45* MP0002210_abnormal_sex_determination1.26759248
46MP0000490_abnormal_crypts_of1.20121775
47MP0006054_spinal_hemorrhage1.19809597
48MP0006292_abnormal_olfactory_placode1.19595406
49* MP0001145_abnormal_male_reproductive1.17610687
50MP0000372_irregular_coat_pigmentation1.14957649
51MP0000427_abnormal_hair_cycle1.14350581
52MP0009703_decreased_birth_body1.12935971
53MP0006035_abnormal_mitochondrial_morpho1.12492414
54MP0002233_abnormal_nose_morphology1.12281913
55MP0000428_abnormal_craniofacial_morphol1.11842603
56MP0009672_abnormal_birth_weight1.08609235
57MP0003787_abnormal_imprinting1.08115111
58* MP0002019_abnormal_tumor_incidence1.07074640
59MP0005395_other_phenotype1.05450653
60MP0005394_taste/olfaction_phenotype1.05265668
61MP0005499_abnormal_olfactory_system1.05265668
62MP0002751_abnormal_autonomic_nervous1.04775518
63* MP0001929_abnormal_gametogenesis1.04450326
64MP0000537_abnormal_urethra_morphology1.03426902
65MP0002938_white_spotting1.02398186
66MP0000566_synostosis1.01426766
67MP0003705_abnormal_hypodermis_morpholog0.99357248
68MP0004808_abnormal_hematopoietic_stem0.99249317
69MP0003315_abnormal_perineum_morphology0.95854416
70* MP0000653_abnormal_sex_gland0.95139581
71MP0002092_abnormal_eye_morphology0.95033959
72MP0009053_abnormal_anal_canal0.93492891
73MP0002111_abnormal_tail_morphology0.91009916
74MP0000383_abnormal_hair_follicle0.90678114
75MP0003935_abnormal_craniofacial_develop0.90527901
76MP0000516_abnormal_urinary_system0.89841228
77MP0005367_renal/urinary_system_phenotyp0.89841228
78MP0003755_abnormal_palate_morphology0.89602456
79MP0003283_abnormal_digestive_organ0.89260758
80MP0002006_tumorigenesis0.88849528
81MP0001286_abnormal_eye_development0.88056521
82MP0001177_atelectasis0.87352663
83MP0000432_abnormal_head_morphology0.85556762
84MP0005621_abnormal_cell_physiology0.84561493
85MP0005384_cellular_phenotype0.84526073
86MP0003861_abnormal_nervous_system0.84400790
87MP0002102_abnormal_ear_morphology0.83444474
88MP0010678_abnormal_skin_adnexa0.82097893
89MP0005410_abnormal_fertilization0.82038028
90MP0003938_abnormal_ear_development0.81660298
91MP0005253_abnormal_eye_physiology0.80954171
92MP0002160_abnormal_reproductive_system0.80650666
93MP0003941_abnormal_skin_development0.79393912
94MP0005408_hypopigmentation0.77737900
95MP0000631_abnormal_neuroendocrine_gland0.77027385
96MP0001984_abnormal_olfaction0.76606580
97MP0001919_abnormal_reproductive_system0.76266570
98MP0001545_abnormal_hematopoietic_system0.76036138
99MP0005397_hematopoietic_system_phenotyp0.76036138
100MP0000569_abnormal_digit_pigmentation0.75947469
101MP0000647_abnormal_sebaceous_gland0.71753750
102MP0000703_abnormal_thymus_morphology0.71315785
103MP0002697_abnormal_eye_size0.71056731
104* MP0001119_abnormal_female_reproductive0.70693490
105MP0002877_abnormal_melanocyte_morpholog0.70050804
106MP0005389_reproductive_system_phenotype0.69829964
107MP0006072_abnormal_retinal_apoptosis0.69031980
108MP0003115_abnormal_respiratory_system0.68203713
109MP0002166_altered_tumor_susceptibility0.67966209
110MP0004133_heterotaxia0.67463429
111MP0000049_abnormal_middle_ear0.66968607
112MP0003699_abnormal_female_reproductive0.66516124
113MP0004233_abnormal_muscle_weight0.65700651
114MP0003136_yellow_coat_color0.64820030
115MP0002114_abnormal_axial_skeleton0.63767354
116MP0001188_hyperpigmentation0.63738689
117MP0002925_abnormal_cardiovascular_devel0.63635602
118MP0003698_abnormal_male_reproductive0.63279478
119MP0006036_abnormal_mitochondrial_physio0.63170786
120MP0001764_abnormal_homeostasis0.62628657
121MP0008995_early_reproductive_senescence0.61122775
122MP0008770_decreased_survivor_rate0.60731797
123MP0003936_abnormal_reproductive_system0.60487851
124MP0001915_intracranial_hemorrhage0.59454089
125MP0002161_abnormal_fertility/fecundity0.58991362
126MP0009250_abnormal_appendicular_skeleto0.58527392
127MP0000358_abnormal_cell_content/0.58199796
128MP0001849_ear_inflammation0.58097505
129MP0002075_abnormal_coat/hair_pigmentati0.57606062
130MP0005391_vision/eye_phenotype0.57126066
131MP0000627_abnormal_mammary_gland0.56995266
132MP0009278_abnormal_bone_marrow0.56865627
133MP0003221_abnormal_cardiomyocyte_apopto0.56835602
134MP0009333_abnormal_splenocyte_physiolog0.54271468
135MP0000371_diluted_coat_color0.53126992

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.31667828
2Chromsome breakage (HP:0040012)4.47789431
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.31608092
4Ependymoma (HP:0002888)4.19861887
5Abnormality of the labia minora (HP:0012880)4.16682697
6Breast hypoplasia (HP:0003187)3.94964631
7Patellar aplasia (HP:0006443)3.59960369
8Impulsivity (HP:0100710)3.55226048
9Absent radius (HP:0003974)3.45408319
10Medulloblastoma (HP:0002885)3.42022368
11Aplasia/Hypoplasia of the patella (HP:0006498)3.36438580
12* Abnormality of chromosome stability (HP:0003220)3.33806949
13Aplasia involving forearm bones (HP:0009822)3.29653583
14Absent forearm bone (HP:0003953)3.29653583
15Abnormality of the astrocytes (HP:0100707)3.19741021
16Astrocytoma (HP:0009592)3.19741021
17Abnormal lung lobation (HP:0002101)3.18958836
18Rhabdomyosarcoma (HP:0002859)3.06993575
19* Meckel diverticulum (HP:0002245)3.06234034
20Volvulus (HP:0002580)3.02044263
21* Abnormality of the ileum (HP:0001549)2.98244870
22Facial hemangioma (HP:0000329)2.97205582
23Glioma (HP:0009733)2.96390489
24* Clubbing of toes (HP:0100760)2.90017710
25* Aplasia/Hypoplasia of the uvula (HP:0010293)2.85603209
26* Abnormality of the preputium (HP:0100587)2.82921750
27Neoplasm of the oral cavity (HP:0100649)2.78411497
28Selective tooth agenesis (HP:0001592)2.74779514
29Ectopic kidney (HP:0000086)2.72711234
30Agnosia (HP:0010524)2.62561970
31Colon cancer (HP:0003003)2.61831461
32Carpal bone hypoplasia (HP:0001498)2.59241459
33Neoplasm of striated muscle (HP:0009728)2.55771851
34* Small intestinal stenosis (HP:0012848)2.53060371
35* Duodenal stenosis (HP:0100867)2.53060371
36Atresia of the external auditory canal (HP:0000413)2.52939797
37Proximal placement of thumb (HP:0009623)2.50087708
38Abnormality of DNA repair (HP:0003254)2.47267809
39Increased nuchal translucency (HP:0010880)2.43892330
40Prominent nose (HP:0000448)2.42925149
41Abnormal number of incisors (HP:0011064)2.40131908
42Deviation of the thumb (HP:0009603)2.38536734
43Absent thumb (HP:0009777)2.35886298
44* Cafe-au-lait spot (HP:0000957)2.35393669
45* Myelodysplasia (HP:0002863)2.34449717
46Degeneration of anterior horn cells (HP:0002398)2.33415787
47Abnormality of the anterior horn cell (HP:0006802)2.33415787
48Aplasia/Hypoplasia of the sternum (HP:0006714)2.31134676
49Bifid tongue (HP:0010297)2.28425790
50* Sloping forehead (HP:0000340)2.26961734
51Shawl scrotum (HP:0000049)2.23513540
52Basal cell carcinoma (HP:0002671)2.21675941
53Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.21571701
54Aplasia/hypoplasia of the humerus (HP:0006507)2.18500246
55Methylmalonic acidemia (HP:0002912)2.18331426
56Rough bone trabeculation (HP:0100670)2.17822641
57Cerebral hypomyelination (HP:0006808)2.16867655
58Oligodactyly (HP:0012165)2.12498611
59Tubulointerstitial nephritis (HP:0001970)2.11869223
60Oligodactyly (hands) (HP:0001180)2.10456977
61Short thumb (HP:0009778)2.08854941
62Neoplasm of the pancreas (HP:0002894)2.08189888
63* Abnormality of the duodenum (HP:0002246)2.07966176
64* Abnormality of the carotid arteries (HP:0005344)2.06878191
65Oral leukoplakia (HP:0002745)2.05048599
66Combined immunodeficiency (HP:0005387)2.03175061
67Horseshoe kidney (HP:0000085)2.03082345
68Supernumerary spleens (HP:0009799)2.02909606
69Squamous cell carcinoma (HP:0002860)2.02525446
70Cortical dysplasia (HP:0002539)2.01767375
71* Bone marrow hypocellularity (HP:0005528)2.01400601
72Aplasia/Hypoplasia of the earlobes (HP:0009906)2.01026682
73Sparse lateral eyebrow (HP:0005338)2.00106129
74Nephroblastoma (Wilms tumor) (HP:0002667)1.99799121
75* Arteriovenous malformation (HP:0100026)1.98837245
76Intestinal fistula (HP:0100819)1.98483684
77Pancreatic cysts (HP:0001737)1.98178296
78Rib fusion (HP:0000902)1.96224396
79Rectovaginal fistula (HP:0000143)1.96071997
80Rectal fistula (HP:0100590)1.96071997
81Short humerus (HP:0005792)1.95029231
82Gastrointestinal carcinoma (HP:0002672)1.94578913
83Malignant gastrointestinal tract tumors (HP:0006749)1.94578913
84Biliary tract neoplasm (HP:0100574)1.94376134
85Anal stenosis (HP:0002025)1.94242890
86Heterotopia (HP:0002282)1.93501584
87B lymphocytopenia (HP:0010976)1.93194676
88Duplicated collecting system (HP:0000081)1.91120480
89* Tracheoesophageal fistula (HP:0002575)1.90685970
90Spinal muscular atrophy (HP:0007269)1.89552331
91Abnormality of methionine metabolism (HP:0010901)1.89243903
92Hyperglycinemia (HP:0002154)1.89103804
93Premature graying of hair (HP:0002216)1.88647089
94Abnormality of chromosome segregation (HP:0002916)1.88026785
95Abnormality of the fingertips (HP:0001211)1.87854891
96* Astigmatism (HP:0000483)1.86746311
97Ureteral duplication (HP:0000073)1.85027825
98* Triphalangeal thumb (HP:0001199)1.84956793
99Pancreatic fibrosis (HP:0100732)1.84005219
100Short 4th metacarpal (HP:0010044)1.82839138
101Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82839138
102Neoplasm of the colon (HP:0100273)1.82637016
103Long eyelashes (HP:0000527)1.82573461
104Embryonal renal neoplasm (HP:0011794)1.82485607
105Abnormality of the salivary glands (HP:0010286)1.81994186
106Microtia (HP:0008551)1.81785972
107Papillary thyroid carcinoma (HP:0002895)1.81627793
108Reticulocytopenia (HP:0001896)1.81313739
109Abnormality of the renal collecting system (HP:0004742)1.80430419
110* Choanal atresia (HP:0000453)1.80171129
111Aplasia/Hypoplasia of the tibia (HP:0005772)1.78387138
112Breast aplasia (HP:0100783)1.78306096
113Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78165665
114High pitched voice (HP:0001620)1.78088251
115Premature ovarian failure (HP:0008209)1.77105213
116Small hand (HP:0200055)1.75618889
117Abnormality of B cell number (HP:0010975)1.75499340
118Capillary hemangiomas (HP:0005306)1.75019331
119Acute myeloid leukemia (HP:0004808)1.74370505
120Deep philtrum (HP:0002002)1.74332421
121Skull defect (HP:0001362)1.73950387
122Severe combined immunodeficiency (HP:0004430)1.73106746
123Abnormality of abdominal situs (HP:0011620)1.71904730
124Abdominal situs inversus (HP:0003363)1.71904730
125Abnormality of serum amino acid levels (HP:0003112)1.71827916
126Acute lymphatic leukemia (HP:0006721)1.71653187
127Dandy-Walker malformation (HP:0001305)1.71644934
128Aplasia/Hypoplasia of the tongue (HP:0010295)1.70728581
129Renal cortical cysts (HP:0000803)1.70463267
130Cystic hygroma (HP:0000476)1.69917592
131Abnormality of alanine metabolism (HP:0010916)1.69564686
132Hyperalaninemia (HP:0003348)1.69564686
133Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69564686
134Preaxial hand polydactyly (HP:0001177)1.69052811
135Hypoplasia of the radius (HP:0002984)1.68404506
136Embryonal neoplasm (HP:0002898)1.68133940
137Abnormality of the vitamin B12 metabolism (HP:0004341)1.66036040
138Median cleft lip (HP:0000161)1.65678416
139Abnormality of the pons (HP:0007361)1.64554141
140Ovarian neoplasm (HP:0100615)1.63394967
141Postaxial foot polydactyly (HP:0001830)1.59501925
142Thyroiditis (HP:0100646)1.58133579
143Sandal gap (HP:0001852)1.57775477
144Neoplasm of the adrenal cortex (HP:0100641)1.57620648
145Abnormality of the renal cortex (HP:0011035)1.56881642
146Molar tooth sign on MRI (HP:0002419)1.56774121
147Abnormality of midbrain morphology (HP:0002418)1.56774121

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.53784461
2BUB14.46861485
3WEE14.12991168
4CDK123.57475080
5NEK23.30268831
6TTK2.87121066
7SRPK12.85225119
8NEK12.41199401
9TSSK62.38238528
10EIF2AK12.37844864
11AKT32.34060958
12PBK2.26046088
13PLK12.24101722
14PLK42.12392441
15CHEK22.06060612
16PLK31.94517299
17MKNK21.94309651
18EPHA21.92048525
19PASK1.85399103
20ATR1.85314782
21FRK1.81945780
22CDK71.75766357
23MKNK11.72753753
24BRSK21.72501495
25LATS11.70260745
26ACVR1B1.69635056
27AURKB1.69563012
28MAP4K21.64485705
29CHEK11.60249748
30BMPR1B1.58725460
31WNK31.56291505
32DYRK31.53742759
33CDK41.52127763
34EIF2AK31.51597372
35TLK11.51519009
36MST41.51054669
37TRIM281.50672542
38BRD41.49816817
39STK31.48057154
40PNCK1.37603266
41RPS6KB21.30701458
42MELK1.26520315
43LATS21.26445355
44VRK11.26432120
45ATM1.26150140
46STK38L1.24552386
47ZAK1.23145647
48MAP3K81.17147752
49CDK21.15154866
50BRSK11.06985914
51ALK1.05907147
52STK41.05494107
53AURKA1.04105494
54TNIK1.04004110
55PLK21.02307315
56ERBB31.01813325
57MAPK130.97271496
58TAF10.96001129
59SCYL20.94635733
60CDK80.94381057
61CDK10.92544906
62STK100.90675171
63BCR0.87332380
64MTOR0.82619596
65EEF2K0.81563807
66CCNB10.80930719
67CDK60.78343166
68MAP3K120.74487508
69RPS6KA40.71315694
70IRAK10.69012657
71IRAK20.68628200
72MAP3K40.67815597
73PAK40.63957244
74PIM10.63011688
75TESK20.62868032
76STK160.61856290
77VRK20.61203539
78CSNK2A20.59964926
79BRAF0.59306840
80CSNK1E0.59215791
81CLK10.57640688
82ERBB40.56798788
83PRKCI0.55771792
84CSNK1D0.55673712
85PRKDC0.55250490
86MAP2K70.51670469
87MAP3K100.51196629
88FGFR10.50952663
89CDK90.50896931
90MAPK140.50250087
91TEC0.49447082
92PAK10.48074160
93CSNK2A10.47246115
94EIF2AK20.47045452
95MAP3K90.45778162
96GSK3B0.43531652
97RPS6KA50.42175692
98MAPK100.41964296
99NLK0.41584015
100NEK90.39713302
101INSRR0.38365792
102NME20.37607302
103STK390.37132353
104AKT20.36314605
105CAMK1G0.36142648
106CSNK1G30.34099483
107CSNK1G20.33760108
108MAPK10.32605206
109FGFR30.31773260
110TIE10.31467042
111CAMK1D0.31056125
112AKT10.30526566
113RAF10.29719589
114YES10.29469174
115TGFBR10.28790538
116MARK30.27970236
117NUAK10.27322586
118ICK0.26832051
119TAOK20.21267953
120KSR10.20877322
121DYRK20.20688656
122STK380.20663953
123CDK30.19098244
124MAPK80.17878685
125RPS6KB10.17801495
126CSNK1G10.17122874
127MAP3K60.16695542
128CSNK1A1L0.16673936
129PRKAA10.16237122
130FLT30.15349757
131TYRO30.15180156

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.58922918
2Mismatch repair_Homo sapiens_hsa034304.36248353
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.02166991
4RNA transport_Homo sapiens_hsa030133.53143525
5Cell cycle_Homo sapiens_hsa041103.38345911
6Spliceosome_Homo sapiens_hsa030403.19216571
7Homologous recombination_Homo sapiens_hsa034403.14115609
8RNA polymerase_Homo sapiens_hsa030203.07440974
9Base excision repair_Homo sapiens_hsa034102.92314338
10Nucleotide excision repair_Homo sapiens_hsa034202.85679188
11* Fanconi anemia pathway_Homo sapiens_hsa034602.84725638
12One carbon pool by folate_Homo sapiens_hsa006702.60458631
13Non-homologous end-joining_Homo sapiens_hsa034502.58837976
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.47284289
15mRNA surveillance pathway_Homo sapiens_hsa030152.29343241
16Vitamin B6 metabolism_Homo sapiens_hsa007502.15484846
17Basal transcription factors_Homo sapiens_hsa030222.15287281
18Pyrimidine metabolism_Homo sapiens_hsa002402.02603908
19RNA degradation_Homo sapiens_hsa030182.00450276
20p53 signaling pathway_Homo sapiens_hsa041151.87728108
21Propanoate metabolism_Homo sapiens_hsa006401.87532729
22Protein export_Homo sapiens_hsa030601.71704041
23Proteasome_Homo sapiens_hsa030501.67419528
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.58576752
25Systemic lupus erythematosus_Homo sapiens_hsa053221.49986601
26Oocyte meiosis_Homo sapiens_hsa041141.44314058
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42606370
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39993327
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.32988697
30Ribosome_Homo sapiens_hsa030101.24559280
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17871947
32Viral carcinogenesis_Homo sapiens_hsa052031.16849642
33Purine metabolism_Homo sapiens_hsa002301.15444772
34Epstein-Barr virus infection_Homo sapiens_hsa051691.14857814
35MicroRNAs in cancer_Homo sapiens_hsa052061.09802174
36Steroid biosynthesis_Homo sapiens_hsa001001.09760042
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95244303
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95213637
39mTOR signaling pathway_Homo sapiens_hsa041500.95143522
40Herpes simplex infection_Homo sapiens_hsa051680.82167441
41Hippo signaling pathway_Homo sapiens_hsa043900.81429881
42HTLV-I infection_Homo sapiens_hsa051660.80842688
43Pyruvate metabolism_Homo sapiens_hsa006200.78287438
44Basal cell carcinoma_Homo sapiens_hsa052170.75253783
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.74681268
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74460909
47Biosynthesis of amino acids_Homo sapiens_hsa012300.74227419
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73158953
49Small cell lung cancer_Homo sapiens_hsa052220.72699492
50Selenocompound metabolism_Homo sapiens_hsa004500.71666468
51Alcoholism_Homo sapiens_hsa050340.71299480
52Pentose phosphate pathway_Homo sapiens_hsa000300.70879212
53TGF-beta signaling pathway_Homo sapiens_hsa043500.70009451
54Colorectal cancer_Homo sapiens_hsa052100.69520436
55Hedgehog signaling pathway_Homo sapiens_hsa043400.67838192
56Folate biosynthesis_Homo sapiens_hsa007900.67397835
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60687972
58Antigen processing and presentation_Homo sapiens_hsa046120.59427822
59Olfactory transduction_Homo sapiens_hsa047400.57377474
60Thyroid cancer_Homo sapiens_hsa052160.57071185
61Lysine degradation_Homo sapiens_hsa003100.55407647
62Notch signaling pathway_Homo sapiens_hsa043300.55259808
63Butanoate metabolism_Homo sapiens_hsa006500.54864642
64Regulation of autophagy_Homo sapiens_hsa041400.50245359
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.49973032
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49918097
67Caffeine metabolism_Homo sapiens_hsa002320.49281186
68Prostate cancer_Homo sapiens_hsa052150.49115548
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.48858689
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.48805507
71Huntingtons disease_Homo sapiens_hsa050160.48670195
72Phototransduction_Homo sapiens_hsa047440.47180779
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46154782
74Adherens junction_Homo sapiens_hsa045200.44661337
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44430744
76Bladder cancer_Homo sapiens_hsa052190.44398716
77Fatty acid elongation_Homo sapiens_hsa000620.43058642
78Fructose and mannose metabolism_Homo sapiens_hsa000510.42318888
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41824772
80N-Glycan biosynthesis_Homo sapiens_hsa005100.41103014
81Chronic myeloid leukemia_Homo sapiens_hsa052200.40101593
82Pathways in cancer_Homo sapiens_hsa052000.39289469
83FoxO signaling pathway_Homo sapiens_hsa040680.34615090
84Wnt signaling pathway_Homo sapiens_hsa043100.34378291
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34112595
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33631041
87Hepatitis B_Homo sapiens_hsa051610.33172240
88Parkinsons disease_Homo sapiens_hsa050120.32990681
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32449500
90Endometrial cancer_Homo sapiens_hsa052130.32321446
91Fatty acid metabolism_Homo sapiens_hsa012120.32184036
92Metabolic pathways_Homo sapiens_hsa011000.31916421
93Non-small cell lung cancer_Homo sapiens_hsa052230.30896089
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29803675
95Melanoma_Homo sapiens_hsa052180.29476737
96Sulfur metabolism_Homo sapiens_hsa009200.29438429
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28407257
98Circadian rhythm_Homo sapiens_hsa047100.26296210
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26272533
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26160587
101Glutathione metabolism_Homo sapiens_hsa004800.25577359
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24910512
103Pancreatic cancer_Homo sapiens_hsa052120.23924230
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23761266
105HIF-1 signaling pathway_Homo sapiens_hsa040660.23172757
106Apoptosis_Homo sapiens_hsa042100.22902230
107Tight junction_Homo sapiens_hsa045300.22822287
108Renal cell carcinoma_Homo sapiens_hsa052110.22495393
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20041809
110Proteoglycans in cancer_Homo sapiens_hsa052050.19262544
111Inositol phosphate metabolism_Homo sapiens_hsa005620.18972163
112Fatty acid biosynthesis_Homo sapiens_hsa000610.18336889
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18203139
114Taste transduction_Homo sapiens_hsa047420.17977612
115Legionellosis_Homo sapiens_hsa051340.17006993
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.15883319
117Oxidative phosphorylation_Homo sapiens_hsa001900.15476365
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15366594
119AMPK signaling pathway_Homo sapiens_hsa041520.15333352
120Peroxisome_Homo sapiens_hsa041460.15046124
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14869997
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14846632
123Dorso-ventral axis formation_Homo sapiens_hsa043200.14692867
124Renin-angiotensin system_Homo sapiens_hsa046140.13694271
125Primary immunodeficiency_Homo sapiens_hsa053400.11495270
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.10318182
127Nicotine addiction_Homo sapiens_hsa050330.09113459
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.09050208
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.09004216
130Nitrogen metabolism_Homo sapiens_hsa009100.07946736
131beta-Alanine metabolism_Homo sapiens_hsa004100.06979528
132Carbon metabolism_Homo sapiens_hsa012000.06775306
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.06314683
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.06156503
135Tryptophan metabolism_Homo sapiens_hsa003800.05759997
136Influenza A_Homo sapiens_hsa051640.05248445
137Viral myocarditis_Homo sapiens_hsa054160.04452473

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