FAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)7.23550897
2collagen fibril organization (GO:0030199)6.06760621
3bone trabecula formation (GO:0060346)5.60303270
4cellular response to vitamin D (GO:0071305)4.94337815
5positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.65259864
6collagen metabolic process (GO:0032963)4.64383526
7collagen catabolic process (GO:0030574)4.62749817
8regulation of type B pancreatic cell apoptotic process (GO:2000674)4.55011309
9sequestering of extracellular ligand from receptor (GO:0035581)4.50614360
10multicellular organismal macromolecule metabolic process (GO:0044259)4.36369619
11axon extension involved in axon guidance (GO:0048846)4.29507010
12neuron projection extension involved in neuron projection guidance (GO:1902284)4.29507010
13interleukin-6-mediated signaling pathway (GO:0070102)4.24702976
14multicellular organismal catabolic process (GO:0044243)4.23850321
15cellular response to vitamin (GO:0071295)4.22421888
16multicellular organismal metabolic process (GO:0044236)4.12110931
17extracellular fibril organization (GO:0043206)4.11916537
18keratan sulfate catabolic process (GO:0042340)4.10707198
19peptide hormone processing (GO:0016486)4.04427622
20negative regulation of complement activation (GO:0045916)4.03852634
21epithelial cell fate commitment (GO:0072148)3.85498679
22negative regulation of execution phase of apoptosis (GO:1900118)3.84373428
23regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.83259054
24skin morphogenesis (GO:0043589)3.80212933
25auditory receptor cell differentiation (GO:0042491)3.79820432
26phosphorylated carbohydrate dephosphorylation (GO:0046838)3.68021665
27inositol phosphate dephosphorylation (GO:0046855)3.68021665
28fibril organization (GO:0097435)3.65126215
29cell proliferation involved in metanephros development (GO:0072203)3.65061735
30cell proliferation involved in kidney development (GO:0072111)3.64457307
31inositol phosphate catabolic process (GO:0071545)3.64050151
32negative regulation of gluconeogenesis (GO:0045721)3.56740249
33mesenchymal-epithelial cell signaling (GO:0060638)3.53762815
34regulation of non-canonical Wnt signaling pathway (GO:2000050)3.52908130
35negative regulation of protein activation cascade (GO:2000258)3.52247471
36response to gravity (GO:0009629)3.51203846
37positive regulation of calcium ion import (GO:0090280)3.45947086
38substrate-dependent cell migration (GO:0006929)3.44541873
39branching involved in salivary gland morphogenesis (GO:0060445)3.44440740
40chondrocyte proliferation (GO:0035988)3.43119791
41glycerophospholipid catabolic process (GO:0046475)3.40498074
42regulation of integrin-mediated signaling pathway (GO:2001044)3.38567726
43extracellular matrix disassembly (GO:0022617)3.37349551
44dermatan sulfate biosynthetic process (GO:0030208)3.36019468
45cell adhesion mediated by integrin (GO:0033627)3.28224774
46COPII vesicle coating (GO:0048208)3.27054845
47biomineral tissue development (GO:0031214)3.24578643
48insulin secretion (GO:0030073)3.19601791
49macroautophagy (GO:0016236)3.17844306
50regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.17358082
51positive regulation of natural killer cell differentiation (GO:0032825)3.13909163
52ganglion development (GO:0061548)3.13771353
53cellular ketone body metabolic process (GO:0046950)3.12322923
54glomerular basement membrane development (GO:0032836)3.11414783
55dermatan sulfate metabolic process (GO:0030205)3.08435205
56regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.08008647
57glial cell migration (GO:0008347)3.05376067
58regulation of skeletal muscle contraction (GO:0014819)3.04755239
59nodal signaling pathway (GO:0038092)3.03500081
60craniofacial suture morphogenesis (GO:0097094)3.03363579
61tooth mineralization (GO:0034505)3.02304090
62extracellular regulation of signal transduction (GO:1900115)3.00770462
63extracellular negative regulation of signal transduction (GO:1900116)3.00770462
64bone remodeling (GO:0046849)2.98678507
65response to vitamin D (GO:0033280)2.97519413
66negative regulation of chondrocyte differentiation (GO:0032331)2.97403383
67chondrocyte development (GO:0002063)2.97057141
68positive regulation of gluconeogenesis (GO:0045722)2.92472704
69regulation of transforming growth factor beta1 production (GO:0032908)2.90824415
70extracellular matrix assembly (GO:0085029)2.90500691
71sphingomyelin metabolic process (GO:0006684)2.89962609
72regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.86843569
73positive regulation of insulin secretion (GO:0032024)2.85570285
74signal peptide processing (GO:0006465)2.83681563
75retinol metabolic process (GO:0042572)2.82523811
76endodermal cell differentiation (GO:0035987)2.82474690
77nitric oxide biosynthetic process (GO:0006809)2.82439008
78bone mineralization (GO:0030282)2.81201017
79negative regulation of humoral immune response (GO:0002921)2.80569166
80positive regulation of histone H3-K4 methylation (GO:0051571)2.80512151
81response to peptidoglycan (GO:0032494)2.80437679
82peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.79555928
83bone morphogenesis (GO:0060349)2.78057738
84positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.77123479
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.75637661
86positive regulation of macroautophagy (GO:0016239)2.75603100
87extracellular matrix organization (GO:0030198)2.74108612
88ketone body metabolic process (GO:1902224)2.73292228
89L-alpha-amino acid transmembrane transport (GO:1902475)2.73084322
90extracellular structure organization (GO:0043062)2.72925747
91type B pancreatic cell proliferation (GO:0044342)2.70483566
92regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.69242590
93positive regulation of transforming growth factor beta production (GO:0071636)2.67299117
94kidney mesenchyme development (GO:0072074)2.65535466
95regulation of T-helper 2 cell differentiation (GO:0045628)2.64945638
96positive regulation of protein autophosphorylation (GO:0031954)2.63553304
97regulation of calcium ion import (GO:0090279)2.62544714
98mesenchyme morphogenesis (GO:0072132)2.60823772
99ossification (GO:0001503)2.59149988
100negative regulation of systemic arterial blood pressure (GO:0003085)2.58515354
101erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.57203380
102L-phenylalanine metabolic process (GO:0006558)2.57203380
103negative regulation of biomineral tissue development (GO:0070168)2.56775608
104cellular response to interferon-alpha (GO:0035457)2.56256164
105regulation of macrophage cytokine production (GO:0010935)2.56166865
106regulation of biomineral tissue development (GO:0070167)2.55319804
107response to BMP (GO:0071772)2.55292962
108cellular response to BMP stimulus (GO:0071773)2.55292962
109negative regulation of osteoblast proliferation (GO:0033689)2.55142698
110positive regulation of macrophage cytokine production (GO:0060907)2.54972839
111embryonic cranial skeleton morphogenesis (GO:0048701)2.54779601
112positive regulation of receptor internalization (GO:0002092)2.54227287
113radial glial cell differentiation (GO:0060019)2.53493932
114endosome to pigment granule transport (GO:0043485)2.53191805
115endosome to melanosome transport (GO:0035646)2.53191805
116regulation of cardiac muscle cell differentiation (GO:2000725)2.52724367
117cellular response to amino acid stimulus (GO:0071230)2.52638965
118polyol catabolic process (GO:0046174)2.52186856
119positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.51630150
120positive regulation of fat cell differentiation (GO:0045600)2.50782607
121negative chemotaxis (GO:0050919)2.50769591
122regulation of bone mineralization (GO:0030500)2.49244899
123regulation of phospholipase A2 activity (GO:0032429)2.49141709
124negative regulation of cartilage development (GO:0061037)2.49136858
125positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.48909793
126regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.48885451
127endothelial cell morphogenesis (GO:0001886)2.48724873
128toxin metabolic process (GO:0009404)2.48662938
129heparin metabolic process (GO:0030202)2.48391700
130heparin biosynthetic process (GO:0030210)2.48391700
131positive regulation of type 2 immune response (GO:0002830)2.47774098
132regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.47372296
133renal tubule morphogenesis (GO:0061333)2.46630446
134negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45712462
135regulation of Rac protein signal transduction (GO:0035020)2.45468869
136virion attachment to host cell (GO:0019062)2.45091854
137adhesion of symbiont to host cell (GO:0044650)2.45091854
138L-phenylalanine catabolic process (GO:0006559)2.44578969
139erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.44578969
140chondroitin sulfate catabolic process (GO:0030207)2.44337313
141protein trimerization (GO:0070206)2.43855122
142regulation of chemokine biosynthetic process (GO:0045073)2.43369891
143outer ear morphogenesis (GO:0042473)2.42203005
144G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.42089990
145prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.41348222
146* regulation of execution phase of apoptosis (GO:1900117)2.41296688
147mesenchymal cell differentiation (GO:0048762)2.41108375
148cellular zinc ion homeostasis (GO:0006882)2.40569708
149water-soluble vitamin biosynthetic process (GO:0042364)2.40435867
150lipid particle organization (GO:0034389)2.40326789
151metanephric mesenchyme development (GO:0072075)2.40294353
152regulation of cardioblast proliferation (GO:0003264)2.40182085
153regulation of secondary heart field cardioblast proliferation (GO:0003266)2.40182085
154cranial suture morphogenesis (GO:0060363)2.39982862
155UDP-N-acetylglucosamine metabolic process (GO:0006047)2.39039222
156cell migration involved in heart development (GO:0060973)2.38949849
157positive regulation of p38MAPK cascade (GO:1900745)2.38924765
158myoblast migration (GO:0051451)2.38772634
159magnesium ion transport (GO:0015693)2.37719471
160regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.37480379
161planar cell polarity pathway involved in neural tube closure (GO:0090179)2.37421459
162positive regulation of fibroblast migration (GO:0010763)2.36918106
163ovulation from ovarian follicle (GO:0001542)2.36880931
164phasic smooth muscle contraction (GO:0014821)2.36621209
165face morphogenesis (GO:0060325)2.36564897
166positive regulation of actin filament depolymerization (GO:0030836)2.36531875
167phospholipid catabolic process (GO:0009395)2.35894894
168growth hormone receptor signaling pathway (GO:0060396)2.35700113
169negative regulation of axon extension involved in axon guidance (GO:0048843)2.35133617
170negative regulation of fatty acid transport (GO:2000192)2.34620991
171zinc ion homeostasis (GO:0055069)2.34388718
172detection of molecule of bacterial origin (GO:0032490)2.34175116
173alanine transport (GO:0032328)2.33787975
174skeletal system development (GO:0001501)2.33387178
175smooth muscle tissue development (GO:0048745)2.33341705
176pteridine-containing compound biosynthetic process (GO:0042559)2.31420539
177* regulation of extracellular matrix disassembly (GO:0010715)2.28821163

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.28883493
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.36577775
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.12818481
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.83983691
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.55601454
6GBX2_23144817_ChIP-Seq_PC3_Human2.54199481
7CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.35034154
8* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.32379090
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31476768
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.30382332
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.28835651
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.17717924
13WT1_19549856_ChIP-ChIP_CCG9911_Human2.08915430
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.03320167
15EED_16625203_ChIP-ChIP_MESCs_Mouse1.99480364
16* CJUN_26792858_Chip-Seq_BT549_Human1.95870618
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.94650900
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92453270
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90974722
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85673394
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.81473440
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74285741
23NRF2_20460467_ChIP-Seq_MEFs_Mouse1.72069862
24NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.72069862
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70382623
26TP53_18474530_ChIP-ChIP_U2OS_Human1.66380688
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.66199430
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.65350544
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57983959
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57290239
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56946481
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.55496630
33BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.55367201
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54884943
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.54396305
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.54396305
37* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53535883
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52881219
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51675422
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50288511
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50018557
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47092247
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.45988570
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45157030
45DROSHA_22980978_ChIP-Seq_HELA_Human1.44274795
46* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.43469103
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39012611
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38180094
49FUS_26573619_Chip-Seq_HEK293_Human1.36890907
50AR_21572438_ChIP-Seq_LNCaP_Human1.35114647
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35033065
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.34059005
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.32918882
54BRD4_25478319_ChIP-Seq_HGPS_Human1.32452673
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.31896722
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30128327
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29299620
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.28448669
59P300_19829295_ChIP-Seq_ESCs_Human1.28314211
60BCAT_22108803_ChIP-Seq_LS180_Human1.25374858
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25325577
62P53_22387025_ChIP-Seq_ESCs_Mouse1.25259490
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25206474
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23698536
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.22113062
66SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21014955
67STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20888226
68SMAD4_21799915_ChIP-Seq_A2780_Human1.20870202
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18942126
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.17389333
71JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16999467
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.16493681
73SOX2_18555785_Chip-Seq_ESCs_Mouse1.16371457
74RXR_22108803_ChIP-Seq_LS180_Human1.15978294
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.15746699
76* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15640193
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14864726
78STAT3_23295773_ChIP-Seq_U87_Human1.14841187
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14609823
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14427010
81HTT_18923047_ChIP-ChIP_STHdh_Human1.13881997
82CDX2_22108803_ChIP-Seq_LS180_Human1.13065972
83TCF4_18268006_ChIP-ChIP_LS174T_Human1.12714021
84IGF1R_20145208_ChIP-Seq_DFB_Human1.12685189
85MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11772053
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11609458
87AHR_22903824_ChIP-Seq_MCF-7_Human1.10579553
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10508438
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10439133
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.10192084
91HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09123798
92TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08330757
93TP53_16413492_ChIP-PET_HCT116_Human1.08055752
94MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06825070
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06523121
96TP63_23658742_ChIP-Seq_EP156T_Human1.04313024
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.03320780
98BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01210022
99OCT4_18555785_Chip-Seq_ESCs_Mouse1.01046892
100KDM2B_26808549_Chip-Seq_REH_Human1.00958382
101* NMYC_18555785_Chip-Seq_ESCs_Mouse1.00604660
102VDR_24787735_ChIP-Seq_THP-1_Human0.99889998
103ER_23166858_ChIP-Seq_MCF-7_Human0.99392519
104EGR1_19374776_ChIP-ChIP_THP-1_Human0.99221363
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99157552
106OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99113709
107IRF8_21731497_ChIP-ChIP_J774_Mouse0.98543861
108FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97993065
109SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97895808
110SOX2_20726797_ChIP-Seq_SW620_Human0.97848852
111TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97658938
112SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97628214
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97003240
114* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96992969
115SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96268268
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96201662
117IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95993551
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95711134
119SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95155256
120SALL1_21062744_ChIP-ChIP_HESCs_Human0.95049508
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94758040
122TCF4_23295773_ChIP-Seq_U87_Human0.94687256
123NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94599497
124P300_18555785_Chip-Seq_ESCs_Mouse0.94345448
125POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94004310
126CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93475787
127SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93417343
128ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92876287
129NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92689713
130* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92319067
131ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91928535
132* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91826293
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91497201
134PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91172816
135E2F1_18555785_Chip-Seq_ESCs_Mouse0.90603644
136* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90391113
137TP53_20018659_ChIP-ChIP_R1E_Mouse0.90326186
138EZH2_27294783_Chip-Seq_NPCs_Mouse0.89431377
139SMAD3_21741376_ChIP-Seq_EPCs_Human0.89386141
140FLI1_27457419_Chip-Seq_LIVER_Mouse0.89359004
141CLOCK_20551151_ChIP-Seq_293T_Human0.86409402
142FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86282068
143AR_25329375_ChIP-Seq_VCAP_Human0.85852213
144STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85405758
145SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85395295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.53953080
2MP0005503_abnormal_tendon_morphology7.62604546
3MP0005275_abnormal_skin_tensile6.15191466
4MP0000013_abnormal_adipose_tissue3.73241501
5MP0002837_dystrophic_cardiac_calcinosis3.63667395
6MP0001542_abnormal_bone_strength3.44754388
7MP0002254_reproductive_system_inflammat3.42813891
8MP0005257_abnormal_intraocular_pressure3.07609022
9MP0005379_endocrine/exocrine_gland_phen2.85222189
10MP0004272_abnormal_basement_membrane2.79697217
11MP0002108_abnormal_muscle_morphology2.64823026
12MP0001958_emphysema2.46041620
13MP0005508_abnormal_skeleton_morphology2.44596860
14MP0003279_aneurysm2.42066564
15MP0002998_abnormal_bone_remodeling2.40135627
16MP0002896_abnormal_bone_mineralization2.26294427
17MP0002060_abnormal_skin_morphology2.18626406
18MP0002909_abnormal_adrenal_gland2.04152297
19MP0005171_absent_coat_pigmentation2.01392525
20MP0010234_abnormal_vibrissa_follicle1.97982280
21MP0009250_abnormal_appendicular_skeleto1.97184067
22MP0002163_abnormal_gland_morphology1.94777910
23MP0003705_abnormal_hypodermis_morpholog1.92823433
24MP0006054_spinal_hemorrhage1.84531647
25MP0001944_abnormal_pancreas_morphology1.83159179
26MP0002139_abnormal_hepatobiliary_system1.78026359
27MP0005390_skeleton_phenotype1.76701504
28MP0000003_abnormal_adipose_tissue1.64449923
29MP0004134_abnormal_chest_morphology1.61192051
30MP0010030_abnormal_orbit_morphology1.60041160
31MP0001756_abnormal_urination1.55826559
32MP0002295_abnormal_pulmonary_circulatio1.52766446
33MP0006072_abnormal_retinal_apoptosis1.50099550
34MP0005645_abnormal_hypothalamus_physiol1.49795477
35MP0002876_abnormal_thyroid_physiology1.47942699
36MP0004185_abnormal_adipocyte_glucose1.47368052
37MP0002115_abnormal_skeleton_extremities1.42860929
38MP0001533_abnormal_skeleton_physiology1.40031479
39MP0001243_abnormal_dermal_layer1.38638929
40MP0000163_abnormal_cartilage_morphology1.38060691
41MP0004270_analgesia1.36062181
42MP0000733_abnormal_muscle_development1.33541431
43MP0010368_abnormal_lymphatic_system1.33150431
44MP0010352_gastrointestinal_tract_polyps1.32023760
45MP0002693_abnormal_pancreas_physiology1.31083892
46MP0000751_myopathy1.30809793
47MP0001299_abnormal_eye_distance/1.29283583
48MP0003385_abnormal_body_wall1.28507842
49MP0005084_abnormal_gallbladder_morpholo1.28232318
50MP0002933_joint_inflammation1.26900584
51MP0002938_white_spotting1.26512822
52MP0002113_abnormal_skeleton_development1.26359952
53MP0003283_abnormal_digestive_organ1.21975454
54MP0005332_abnormal_amino_acid1.19234193
55MP0005646_abnormal_pituitary_gland1.18898110
56MP0002932_abnormal_joint_morphology1.18740946
57MP0003795_abnormal_bone_structure1.18071469
58MP0004019_abnormal_vitamin_homeostasis1.15820475
59MP0000538_abnormal_urinary_bladder1.12597199
60MP0003566_abnormal_cell_adhesion1.11097343
61MP0010329_abnormal_lipoprotein_level1.10929020
62MP0003950_abnormal_plasma_membrane1.10519561
63MP0002006_tumorigenesis1.10357607
64MP0003172_abnormal_lysosome_physiology1.07621220
65MP0002282_abnormal_trachea_morphology1.06238071
66MP0005220_abnormal_exocrine_pancreas1.03369774
67MP0005164_abnormal_response_to1.03311780
68MP0005023_abnormal_wound_healing1.02989654
69MP0004510_myositis1.02779798
70MP0002109_abnormal_limb_morphology0.99590202
71MP0000566_synostosis0.98717920
72MP0005369_muscle_phenotype0.97378196
73MP0005174_abnormal_tail_pigmentation0.95878830
74MP0003724_increased_susceptibility_to0.92883051
75MP0002168_other_aberrant_phenotype0.92472289
76MP0006082_CNS_inflammation0.91553990
77MP0002116_abnormal_craniofacial_bone0.91197543
78MP0001661_extended_life_span0.90244354
79MP0000516_abnormal_urinary_system0.88158299
80MP0005367_renal/urinary_system_phenotyp0.88158299
81MP0001346_abnormal_lacrimal_gland0.87266825
82MP0000639_abnormal_adrenal_gland0.87240007
83MP0000767_abnormal_smooth_muscle0.86370479
84MP0009384_cardiac_valve_regurgitation0.85827893
85MP0009046_muscle_twitch0.85407790
86MP0002078_abnormal_glucose_homeostasis0.84526865
87MP0003045_fibrosis0.84244520
88MP0002233_abnormal_nose_morphology0.83615550
89MP0000428_abnormal_craniofacial_morphol0.83002192
90MP0001879_abnormal_lymphatic_vessel0.81809717
91MP0002166_altered_tumor_susceptibility0.80975705
92MP0004883_abnormal_blood_vessel0.80421141
93MP0000432_abnormal_head_morphology0.78155714
94MP0002148_abnormal_hypersensitivity_rea0.78037633
95MP0003935_abnormal_craniofacial_develop0.76244296
96MP0002009_preneoplasia0.76153129
97MP0009785_altered_susceptibility_to0.75302340
98MP0005623_abnormal_meninges_morphology0.74776700
99MP0001835_abnormal_antigen_presentation0.74041626
100MP0000569_abnormal_digit_pigmentation0.73457263
101MP0003755_abnormal_palate_morphology0.72987864
102MP0000343_altered_response_to0.72643822
103MP0004133_heterotaxia0.72493203
104MP0004885_abnormal_endolymph0.72070480
105MP0003195_calcinosis0.71458526
106MP0008775_abnormal_heart_ventricle0.69962306
107MP0003941_abnormal_skin_development0.69563020
108MP0000015_abnormal_ear_pigmentation0.69329298
109MP0002249_abnormal_larynx_morphology0.69295982
110MP0000230_abnormal_systemic_arterial0.69024533
111MP0009053_abnormal_anal_canal0.68971539
112MP0005408_hypopigmentation0.68016966
113MP0002089_abnormal_postnatal_growth/wei0.67845139
114MP0005595_abnormal_vascular_smooth0.66625508
115MP0000372_irregular_coat_pigmentation0.66383052
116MP0003252_abnormal_bile_duct0.65074710
117MP0000762_abnormal_tongue_morphology0.63324991
118MP0000427_abnormal_hair_cycle0.62102404
119MP0009278_abnormal_bone_marrow0.60831832
120MP0001175_abnormal_lung_morphology0.60716342
121MP0003091_abnormal_cell_migration0.59820218
122MP0001501_abnormal_sleep_pattern0.59028182
123MP0003633_abnormal_nervous_system0.57613718
124MP0005248_abnormal_Harderian_gland0.57423922
125MP0010386_abnormal_urinary_bladder0.56237092
126MP0004808_abnormal_hematopoietic_stem0.54589251
127MP0002114_abnormal_axial_skeleton0.54198552
128MP0009840_abnormal_foam_cell0.53739378
129MP0001765_abnormal_ion_homeostasis0.52657544
130MP0002127_abnormal_cardiovascular_syste0.52244426
131MP0005253_abnormal_eye_physiology0.52211532
132MP0009780_abnormal_chondrocyte_physiolo0.51824647
133MP0003953_abnormal_hormone_level0.51776815
134MP0003122_maternal_imprinting0.51267639
135MP0005448_abnormal_energy_balance0.50990359
136MP0000579_abnormal_nail_morphology0.50803074
137MP0003868_abnormal_feces_composition0.50723592
138MP0002177_abnormal_outer_ear0.50695094
139MP0002106_abnormal_muscle_physiology0.50668374
140MP0005388_respiratory_system_phenotype0.50527571
141MP0002133_abnormal_respiratory_system0.50527571
142MP0003448_altered_tumor_morphology0.49844854
143MP0005165_increased_susceptibility_to0.49536845
144MP0010771_integument_phenotype0.49478079
145MP0001270_distended_abdomen0.49329761
146MP0000534_abnormal_ureter_morphology0.48986777
147MP0000613_abnormal_salivary_gland0.48919309
148MP0002419_abnormal_innate_immunity0.48729309
149MP0005389_reproductive_system_phenotype0.48453363
150MP0001905_abnormal_dopamine_level0.48334852
151MP0005076_abnormal_cell_differentiation0.48218366
152MP0000049_abnormal_middle_ear0.48149307
153MP0003942_abnormal_urinary_system0.47942148
154MP0001177_atelectasis0.47770049
155MP0003011_delayed_dark_adaptation0.47657525
156MP0009115_abnormal_fat_cell0.47533696

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.65500198
2Premature rupture of membranes (HP:0001788)6.92344146
3Soft skin (HP:0000977)4.88719278
4Broad metatarsal (HP:0001783)4.68134049
5Abnormality of dentin (HP:0010299)4.50166938
6Atrophic scars (HP:0001075)4.37148924
7Peritonitis (HP:0002586)4.31238239
8Follicular hyperkeratosis (HP:0007502)4.29403285
9Aortic dissection (HP:0002647)4.24345006
10Biconcave vertebral bodies (HP:0004586)4.23361355
11Type 1 muscle fiber predominance (HP:0003803)3.97822216
12Shallow orbits (HP:0000586)3.91524431
13Neonatal short-limb short stature (HP:0008921)3.81792839
14Wormian bones (HP:0002645)3.75792542
15Ankle contracture (HP:0006466)3.73590894
16Fragile skin (HP:0001030)3.55767021
17Cardiovascular calcification (HP:0011915)3.49927720
18Increased CSF protein (HP:0002922)3.42071504
19Bladder diverticulum (HP:0000015)3.39151684
20Blue sclerae (HP:0000592)3.36508558
21Spondylolisthesis (HP:0003302)3.33760599
22Abnormality of aromatic amino acid family metabolism (HP:0004338)3.24951645
23Slender build (HP:0001533)3.09033650
24Double outlet right ventricle (HP:0001719)3.02456523
25Congenital malformation of the right heart (HP:0011723)3.02456523
26Delayed gross motor development (HP:0002194)2.98552309
27Mitral valve prolapse (HP:0001634)2.95986507
28Mucopolysacchariduria (HP:0008155)2.95784753
29Urinary glycosaminoglycan excretion (HP:0003541)2.95784753
30Persistence of primary teeth (HP:0006335)2.95347498
31Abnormality of polysaccharide metabolism (HP:0011012)2.93537943
32Abnormality of glycosaminoglycan metabolism (HP:0004371)2.93537943
33Abnormality of mucopolysaccharide metabolism (HP:0011020)2.93537943
34Genu recurvatum (HP:0002816)2.91905293
35Breech presentation (HP:0001623)2.89758631
36Osteoarthritis (HP:0002758)2.87447821
37Increased connective tissue (HP:0009025)2.85263983
38Hyperextensible skin (HP:0000974)2.84100479
39Spinal rigidity (HP:0003306)2.78854098
40Osteolytic defects of the phalanges of the hand (HP:0009771)2.78714126
41Osteolytic defects of the hand bones (HP:0009699)2.78714126
42Dilatation of the ascending aorta (HP:0005111)2.78696209
43Vascular calcification (HP:0004934)2.77355439
44Metaphyseal dysplasia (HP:0100255)2.74522114
45Femoral bowing (HP:0002980)2.72436700
46Tibial bowing (HP:0002982)2.67939653
47Vertebral compression fractures (HP:0002953)2.67901461
48Decreased skull ossification (HP:0004331)2.65341539
49Abnormal delivery (HP:0001787)2.65201620
50Abnormality of the parietal bone (HP:0002696)2.60848475
51Mild short stature (HP:0003502)2.59095845
52Joint laxity (HP:0001388)2.55731506
53Absent frontal sinuses (HP:0002688)2.53817252
54Intestinal atresia (HP:0011100)2.49810660
55Abnormality of vitamin B metabolism (HP:0004340)2.49076237
56Cervical subluxation (HP:0003308)2.48896240
57Bell-shaped thorax (HP:0001591)2.46613567
58Hyperglycemia (HP:0003074)2.45392168
59Abnormality of the frontal sinuses (HP:0002687)2.44619584
60Abnormality of skull ossification (HP:0002703)2.44592942
61Popliteal pterygium (HP:0009756)2.43932877
62Abnormality of primary teeth (HP:0006481)2.42949803
63Hematochezia (HP:0002573)2.39216521
64Enlarged penis (HP:0000040)2.36527759
65Postural tremor (HP:0002174)2.35858229
66Pulmonary artery stenosis (HP:0004415)2.35696658
67Wide anterior fontanel (HP:0000260)2.35637121
68Aortic regurgitation (HP:0001659)2.35617910
69Orthostatic hypotension (HP:0001278)2.33155956
70Morphological abnormality of the middle ear (HP:0008609)2.32459969
71Keratoconus (HP:0000563)2.26086130
72Increased corneal curvature (HP:0100692)2.26086130
73Cerebral aneurysm (HP:0004944)2.24722866
74Aplasia cutis congenita (HP:0001057)2.24574007
75Abnormality of the nasal septum (HP:0000419)2.24452620
76Broad ribs (HP:0000885)2.23134694
77Round ear (HP:0100830)2.22582010
78Hypoplastic ischia (HP:0003175)2.22433289
79Spinal cord lesions (HP:0100561)2.21916546
80Syringomyelia (HP:0003396)2.21916546
81Buphthalmos (HP:0000557)2.20737426
82Wrist flexion contracture (HP:0001239)2.20641035
83Delayed closure of the anterior fontanelle (HP:0001476)2.20514739
84Progressive neurologic deterioration (HP:0002344)2.18334370
85Congenital sensorineural hearing impairment (HP:0008527)2.17578634
86Vascular tortuosity (HP:0004948)2.16996475
87Bone cyst (HP:0012062)2.16267157
88Flat cornea (HP:0007720)2.16083437
89Hemiparesis (HP:0001269)2.15638785
90Hypoventilation (HP:0002791)2.14443980
91Mildly elevated creatine phosphokinase (HP:0008180)2.13463795
92Overgrowth (HP:0001548)2.12672619
93Bowel diverticulosis (HP:0005222)2.12206822
94Nonimmune hydrops fetalis (HP:0001790)2.11969283
95Aortic aneurysm (HP:0004942)2.11534417
96Conjunctival hamartoma (HP:0100780)2.10092623
97Hamartoma of the eye (HP:0010568)2.09354241
98Hypophosphatemic rickets (HP:0004912)2.08957187
99Congenital glaucoma (HP:0001087)2.07646967
100Gingival overgrowth (HP:0000212)2.07437892
101Joint stiffness (HP:0001387)2.07243487
102Osteomalacia (HP:0002749)2.05283307
103Thin bony cortex (HP:0002753)2.04697015
104Increased variability in muscle fiber diameter (HP:0003557)2.04390240
105Abnormality of abdominal situs (HP:0011620)2.04341727
106Abdominal situs inversus (HP:0003363)2.04341727
107Abnormality of skeletal muscle fiber size (HP:0012084)2.04145705
108Asymmetry of the thorax (HP:0001555)2.03899282
109Nuclear cataract (HP:0100018)2.03274458
110Abnormality of vitamin metabolism (HP:0100508)2.02963694
111Ovoid vertebral bodies (HP:0003300)2.02815144
112Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.02401755
113Dysostosis multiplex (HP:0000943)2.02304859
114Mesomelia (HP:0003027)2.01778727
115Hypothermia (HP:0002045)2.01403983
116Striae distensae (HP:0001065)2.00741311
117Platyspondyly (HP:0000926)2.00073337
118Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.99174253
119Infantile muscular hypotonia (HP:0008947)1.96964767
120Cupped ribs (HP:0000887)1.95989795
121Delayed cranial suture closure (HP:0000270)1.93014538
122Narrow palate (HP:0000189)1.92930150
123Focal dystonia (HP:0004373)1.92722467
124Abnormality of the ischium (HP:0003174)1.92553888
125Gastrointestinal infarctions (HP:0005244)1.92202605
126Protruding ear (HP:0000411)1.91242394
127Thoracolumbar scoliosis (HP:0002944)1.89865472
128Narrow nasal bridge (HP:0000446)1.89780358
129Ulnar bowing (HP:0003031)1.89038266
130Metaphyseal cupping (HP:0003021)1.85913640
131Hypoalbuminemia (HP:0003073)1.85673102
132Abnormal albumin level (HP:0012116)1.85673102
133Abnormality of glycosphingolipid metabolism (HP:0004343)1.83197259
134Abnormality of glycolipid metabolism (HP:0010969)1.83197259
135Abnormality of liposaccharide metabolism (HP:0010968)1.83197259
136Torticollis (HP:0000473)1.82356421
137Irregular vertebral endplates (HP:0003301)1.82309910
138Venous abnormality (HP:0002624)1.82132571
139Mitral stenosis (HP:0001718)1.81503498
140Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80540088
141Venous insufficiency (HP:0005293)1.79537688
142Hypoplasia of the iris (HP:0007676)1.77455222
143Mitral regurgitation (HP:0001653)1.77391935
144Mesangial abnormality (HP:0001966)1.76813914
145Albinism (HP:0001022)1.76579646
146Broad long bones (HP:0005622)1.76125920
147Methylmalonic acidemia (HP:0002912)1.74123531
148Abnormality of the acetabulum (HP:0003170)1.73838401
149Osteopenia (HP:0000938)1.73230048
150Proximal tubulopathy (HP:0000114)1.71671148
151Small epiphyses (HP:0010585)1.71094871
152Slender long bone (HP:0003100)1.71001741
153Aortic valve stenosis (HP:0001650)1.70958669
154Inguinal hernia (HP:0000023)1.70878825
155Calcaneovalgus deformity (HP:0001848)1.70732603
156Flared iliac wings (HP:0002869)1.66900630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.19435662
2EPHA34.31625269
3MAP4K22.92394433
4PDGFRA2.80440694
5FGFR42.66157506
6MAP3K122.58238293
7FGFR32.54633786
8CASK2.49465916
9FRK2.45642791
10PHKG22.43131303
11PHKG12.43131303
12SIK12.29845354
13JAK12.28714092
14GRK12.22993262
15EPHB22.21000668
16NLK2.18783960
17TGFBR22.12489771
18MST42.02768914
19BMPR22.02043245
20FGFR22.00767474
21JAK31.98189680
22MAP3K141.92057949
23LIMK11.90588398
24IRAK41.88520191
25STK241.87946987
26TRPM71.84609603
27ADRBK21.83993102
28LATS11.79946608
29EPHB11.68174296
30OBSCN1.66633259
31MAP2K61.58622526
32PINK11.56163567
33ZAK1.53232752
34IKBKE1.52949388
35WNK31.51138116
36IKBKB1.50064870
37PRKD31.47429371
38EIF2AK21.47321122
39PDGFRB1.45320630
40IRAK11.44875371
41PRKD21.42341778
42PTK21.42005876
43CHUK1.41238827
44WNK41.34007948
45FER1.32665806
46MAPKAPK31.32527795
47RIPK11.29874048
48ERN11.29610447
49TYK21.28790292
50TTN1.27989579
51KIT1.24562911
52IRAK31.20735156
53ERBB31.19091476
54NUAK11.17534402
55EIF2AK31.15799647
56MAP3K31.12996809
57PIK3CA1.12931048
58FGFR11.10894205
59PTK2B1.08893815
60PLK21.07443843
61SGK21.06104692
62MAP3K91.05333692
63NTRK31.03126840
64CAMK2D1.00401637
65MST1R0.99038112
66INSRR0.94305378
67TESK10.92424536
68ACVR1B0.89792792
69PAK20.86847851
70NEK90.86664008
71BMPR1B0.86134321
72TGFBR10.84832756
73ILK0.84636784
74PRKG20.84295583
75PRKCE0.83670640
76BMX0.82310651
77STK380.80231720
78PAK40.79374403
79MAP3K40.76988128
80MYLK0.76800408
81CSNK1G10.76682144
82TXK0.76670257
83STK390.74543831
84TBK10.73247438
85PIK3CG0.71046900
86CAMK1D0.70980687
87FLT30.70508615
88AKT30.70033858
89SGK30.69864799
90ROCK20.69661993
91MAPK70.68804839
92MAP2K10.67570398
93PRKCI0.65517764
94RPS6KA40.64803290
95IRAK20.64620126
96MAP3K20.64402235
97STK30.60486587
98PBK0.60478874
99JAK20.60022991
100TNK20.59560658
101CDC42BPA0.58949280
102MUSK0.56621653
103PRKCG0.55074909
104PTK60.53356824
105WNK10.50012982
106SIK30.49531017
107RIPK40.48499102
108SGK2230.47181718
109SGK4940.47181718
110ABL20.46878444
111EIF2AK10.46512532
112GSK3A0.46101744
113MET0.45514882
114ROCK10.45045388
115NEK60.44452664
116CAMK2G0.44254886
117PIM20.42303772
118BTK0.42122438
119HCK0.41716742
120CSNK1G20.41713520
121MAPKAPK50.41502855
122STK40.41281097
123PRKAA20.41222498
124INSR0.40541655
125CSNK1G30.40127519
126DMPK0.39928249
127TNIK0.39590697
128CAMK40.39150561
129CAMK1G0.38947844
130DAPK30.38796515
131PRKG10.38654593
132ADRBK10.36995142
133MAPK150.34915356
134CAMK2A0.34794085
135ABL10.34352283
136IGF1R0.33965538
137STK38L0.33610242
138TIE10.33322446
139TEC0.32691185
140LMTK20.32273002
141CAMKK20.32049167
142PRKCH0.31209122
143MAPK130.31002630
144NTRK10.30923676
145HIPK20.29996396
146PRKCD0.29127169
147PAK30.28155199
148YES10.27421502
149PRKD10.27239438
150ZAP700.27037209
151TRIB30.26944262
152DAPK20.26258378
153PRKAA10.25968875
154GRK50.25796307
155ERBB40.25734983
156ERBB20.24904554
157MAPK10.24048545
158MAP3K130.23845493

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.94690890
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.65710128
3Protein digestion and absorption_Homo sapiens_hsa049742.96391984
4Sulfur metabolism_Homo sapiens_hsa009202.90227678
5Malaria_Homo sapiens_hsa051442.66088287
6Protein export_Homo sapiens_hsa030602.59530328
7Folate biosynthesis_Homo sapiens_hsa007902.47919351
8Graft-versus-host disease_Homo sapiens_hsa053322.29314432
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.17246540
10Vitamin B6 metabolism_Homo sapiens_hsa007502.13146379
11AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.10155556
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06528226
13Focal adhesion_Homo sapiens_hsa045102.05017640
14Rheumatoid arthritis_Homo sapiens_hsa053232.03877206
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.00842163
16Other glycan degradation_Homo sapiens_hsa005111.94620799
17Amoebiasis_Homo sapiens_hsa051461.88071544
18Insulin secretion_Homo sapiens_hsa049111.88011258
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85987750
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84725936
21Sphingolipid metabolism_Homo sapiens_hsa006001.83860373
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82465054
23TNF signaling pathway_Homo sapiens_hsa046681.80855913
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.79781786
25Collecting duct acid secretion_Homo sapiens_hsa049661.76847817
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.74695473
27African trypanosomiasis_Homo sapiens_hsa051431.69311297
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.65059929
29Leishmaniasis_Homo sapiens_hsa051401.64175257
30Selenocompound metabolism_Homo sapiens_hsa004501.63500198
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.62393599
32Legionellosis_Homo sapiens_hsa051341.57955674
33Vibrio cholerae infection_Homo sapiens_hsa051101.55259663
34Pertussis_Homo sapiens_hsa051331.51507474
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.51494717
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.51027895
37Dilated cardiomyopathy_Homo sapiens_hsa054141.49621704
38Toxoplasmosis_Homo sapiens_hsa051451.48162473
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45071831
40Basal cell carcinoma_Homo sapiens_hsa052171.44364718
41Osteoclast differentiation_Homo sapiens_hsa043801.42627142
42Allograft rejection_Homo sapiens_hsa053301.32405809
43Proteoglycans in cancer_Homo sapiens_hsa052051.31363282
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23203104
45Butanoate metabolism_Homo sapiens_hsa006501.20698805
46PI3K-Akt signaling pathway_Homo sapiens_hsa041511.17413402
47Measles_Homo sapiens_hsa051621.16944463
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.15753126
49Ether lipid metabolism_Homo sapiens_hsa005651.13497589
50Oxidative phosphorylation_Homo sapiens_hsa001901.13263008
51TGF-beta signaling pathway_Homo sapiens_hsa043501.12188051
52Viral myocarditis_Homo sapiens_hsa054161.09209738
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09091053
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08103041
55N-Glycan biosynthesis_Homo sapiens_hsa005101.08058957
56Complement and coagulation cascades_Homo sapiens_hsa046101.07534679
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07476429
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07190984
59Arginine biosynthesis_Homo sapiens_hsa002201.06471252
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06142087
61Tuberculosis_Homo sapiens_hsa051521.04128460
62Salmonella infection_Homo sapiens_hsa051321.02519979
63Glucagon signaling pathway_Homo sapiens_hsa049221.00811760
64Hedgehog signaling pathway_Homo sapiens_hsa043400.99565506
65Adherens junction_Homo sapiens_hsa045200.97398740
66Small cell lung cancer_Homo sapiens_hsa052220.96768149
67Influenza A_Homo sapiens_hsa051640.94238975
68Phagosome_Homo sapiens_hsa041450.92980446
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92148057
70MicroRNAs in cancer_Homo sapiens_hsa052060.90516091
71Platelet activation_Homo sapiens_hsa046110.88609753
72Hematopoietic cell lineage_Homo sapiens_hsa046400.88074510
73Wnt signaling pathway_Homo sapiens_hsa043100.85030128
74Tryptophan metabolism_Homo sapiens_hsa003800.83959880
75Melanoma_Homo sapiens_hsa052180.83241846
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82550875
77Glutathione metabolism_Homo sapiens_hsa004800.82377838
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82277897
79Pathways in cancer_Homo sapiens_hsa052000.80499719
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80163710
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80137729
82Insulin resistance_Homo sapiens_hsa049310.79622393
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79521432
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79416342
85Fatty acid elongation_Homo sapiens_hsa000620.78460601
86Hepatitis B_Homo sapiens_hsa051610.77238318
87Serotonergic synapse_Homo sapiens_hsa047260.77145166
88Propanoate metabolism_Homo sapiens_hsa006400.77057746
89Prolactin signaling pathway_Homo sapiens_hsa049170.76636563
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76377818
91Chemokine signaling pathway_Homo sapiens_hsa040620.76322189
92Prostate cancer_Homo sapiens_hsa052150.75815874
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74479753
94HTLV-I infection_Homo sapiens_hsa051660.73084678
95Dorso-ventral axis formation_Homo sapiens_hsa043200.72393270
96Type II diabetes mellitus_Homo sapiens_hsa049300.72346063
97GABAergic synapse_Homo sapiens_hsa047270.72286054
98Dopaminergic synapse_Homo sapiens_hsa047280.71809372
99Axon guidance_Homo sapiens_hsa043600.71094627
100FoxO signaling pathway_Homo sapiens_hsa040680.70819795
101Renin secretion_Homo sapiens_hsa049240.70801427
102Circadian entrainment_Homo sapiens_hsa047130.70104008
103Herpes simplex infection_Homo sapiens_hsa051680.69662880
104Type I diabetes mellitus_Homo sapiens_hsa049400.68351995
105Apoptosis_Homo sapiens_hsa042100.68349603
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68057052
107Prion diseases_Homo sapiens_hsa050200.65579729
108Renin-angiotensin system_Homo sapiens_hsa046140.64867601
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63966378
110Glutamatergic synapse_Homo sapiens_hsa047240.63023445
111Long-term depression_Homo sapiens_hsa047300.62883871
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62724636
113Autoimmune thyroid disease_Homo sapiens_hsa053200.62682243
114MAPK signaling pathway_Homo sapiens_hsa040100.62501272
115Synaptic vesicle cycle_Homo sapiens_hsa047210.61720493
116Phototransduction_Homo sapiens_hsa047440.61667177
117Alzheimers disease_Homo sapiens_hsa050100.61554060
118Amphetamine addiction_Homo sapiens_hsa050310.61339986
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.60965694
120Asthma_Homo sapiens_hsa053100.60846742
121Staphylococcus aureus infection_Homo sapiens_hsa051500.59618352
122ABC transporters_Homo sapiens_hsa020100.58916372
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.58837235
124Chronic myeloid leukemia_Homo sapiens_hsa052200.57722231
125Peroxisome_Homo sapiens_hsa041460.57364108
126Hippo signaling pathway_Homo sapiens_hsa043900.57304659
127Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56831549
128Pancreatic cancer_Homo sapiens_hsa052120.55909173
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55704352
130Pancreatic secretion_Homo sapiens_hsa049720.55113227
131Thyroid hormone synthesis_Homo sapiens_hsa049180.54430329
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.54075469
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53674181
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.51673452
135Notch signaling pathway_Homo sapiens_hsa043300.50672178
136Melanogenesis_Homo sapiens_hsa049160.49994012
137Calcium signaling pathway_Homo sapiens_hsa040200.49462904
138Hepatitis C_Homo sapiens_hsa051600.49453060
139Tight junction_Homo sapiens_hsa045300.48341526
140Linoleic acid metabolism_Homo sapiens_hsa005910.47151754
141Arachidonic acid metabolism_Homo sapiens_hsa005900.46985040
142Circadian rhythm_Homo sapiens_hsa047100.46848253
143Metabolic pathways_Homo sapiens_hsa011000.46760818
144Mineral absorption_Homo sapiens_hsa049780.46583342
145Salivary secretion_Homo sapiens_hsa049700.46232807
146Rap1 signaling pathway_Homo sapiens_hsa040150.45983259
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45684636
148Cocaine addiction_Homo sapiens_hsa050300.45549930
149Retinol metabolism_Homo sapiens_hsa008300.42995423
150cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42452682
151Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41771862
152Lysosome_Homo sapiens_hsa041420.39510862
153alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38852594
154Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38768495
155Ras signaling pathway_Homo sapiens_hsa040140.38552741
156Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38061024
157cAMP signaling pathway_Homo sapiens_hsa040240.37714257
158Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36604635
159GnRH signaling pathway_Homo sapiens_hsa049120.36517078
160T cell receptor signaling pathway_Homo sapiens_hsa046600.36478953
161Oxytocin signaling pathway_Homo sapiens_hsa049210.34888447
162Vascular smooth muscle contraction_Homo sapiens_hsa042700.34810988
163Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34019727
164Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33291160
165Sphingolipid signaling pathway_Homo sapiens_hsa040710.32716450

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »