FAR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.49630247
2nuclear pore organization (GO:0006999)6.78173551
3mitotic sister chromatid cohesion (GO:0007064)5.57587142
4pore complex assembly (GO:0046931)5.45308380
5axon ensheathment in central nervous system (GO:0032291)4.23790239
6central nervous system myelination (GO:0022010)4.23790239
7mitotic metaphase plate congression (GO:0007080)4.02588266
8mitotic chromosome condensation (GO:0007076)3.95667563
9sister chromatid segregation (GO:0000819)3.92478684
10DNA unwinding involved in DNA replication (GO:0006268)3.92398765
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.77123975
12metaphase plate congression (GO:0051310)3.73324972
13establishment of chromosome localization (GO:0051303)3.66381812
14negative regulation of neurotransmitter secretion (GO:0046929)3.64785617
15protein localization to kinetochore (GO:0034501)3.60680756
16protein localization to chromosome, centromeric region (GO:0071459)3.57391093
17nerve growth factor signaling pathway (GO:0038180)3.54523633
18mitotic sister chromatid segregation (GO:0000070)3.53810597
19regulation of centriole replication (GO:0046599)3.53038326
20positive regulation of mitotic sister chromatid separation (GO:1901970)3.45981480
21positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.45981480
22positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.45981480
23negative regulation of neurotransmitter transport (GO:0051589)3.45890415
24DNA topological change (GO:0006265)3.44298962
25negative regulation of DNA repair (GO:0045738)3.38376024
26non-recombinational repair (GO:0000726)3.34842904
27double-strand break repair via nonhomologous end joining (GO:0006303)3.34842904
28positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.34538093
29pre-miRNA processing (GO:0031054)3.33373003
30positive regulation of chromosome segregation (GO:0051984)3.31657463
31regulation of mitotic metaphase/anaphase transition (GO:0030071)3.18055380
32regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.18055380
33regulation of RNA export from nucleus (GO:0046831)3.17996838
34regulation of Rac protein signal transduction (GO:0035020)3.17516813
35Rap protein signal transduction (GO:0032486)3.15833884
36monoubiquitinated protein deubiquitination (GO:0035520)3.13859738
37regulation of sister chromatid segregation (GO:0033045)3.13032333
38regulation of mitotic sister chromatid separation (GO:0010965)3.13032333
39regulation of mitotic sister chromatid segregation (GO:0033047)3.13032333
40phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.12146945
41regulation of chromosome segregation (GO:0051983)3.11410855
42iron ion import (GO:0097286)3.03600557
43spindle checkpoint (GO:0031577)3.02248642
44negative regulation of fibroblast apoptotic process (GO:2000270)3.01960790
45cellular protein complex localization (GO:0034629)3.01918532
46mitotic G2 DNA damage checkpoint (GO:0007095)2.99130698
47neutrophil activation involved in immune response (GO:0002283)2.98656740
48protein export from nucleus (GO:0006611)2.97250954
49dosage compensation (GO:0007549)2.96639300
50mitotic G2/M transition checkpoint (GO:0044818)2.96424192
51mitotic spindle checkpoint (GO:0071174)2.95805128
52negative regulation of sister chromatid segregation (GO:0033046)2.94458882
53negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.94458882
54negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94458882
55negative regulation of mitotic sister chromatid segregation (GO:0033048)2.94458882
56negative regulation of mitotic sister chromatid separation (GO:2000816)2.94458882
57mitotic spindle assembly checkpoint (GO:0007094)2.93612863
58ensheathment of neurons (GO:0007272)2.93351045
59axon ensheathment (GO:0008366)2.93351045
60regulation of sister chromatid cohesion (GO:0007063)2.93294577
61myelination (GO:0042552)2.92546907
62establishment of integrated proviral latency (GO:0075713)2.91421756
63negative regulation of chromosome segregation (GO:0051985)2.90953153
64spindle assembly checkpoint (GO:0071173)2.90355029
65nuclear envelope disassembly (GO:0051081)2.90168743
66membrane disassembly (GO:0030397)2.90168743
67locomotory exploration behavior (GO:0035641)2.87521583
68cytoplasmic mRNA processing body assembly (GO:0033962)2.86413876
69long-chain fatty acid biosynthetic process (GO:0042759)2.82763455
70regulation of centrosome duplication (GO:0010824)2.80644766
71NLS-bearing protein import into nucleus (GO:0006607)2.80543104
72mitotic nuclear envelope disassembly (GO:0007077)2.78336454
73DNA duplex unwinding (GO:0032508)2.77293438
74regulation of nucleobase-containing compound transport (GO:0032239)2.74519686
75sister chromatid cohesion (GO:0007062)2.72826387
76histone H2B ubiquitination (GO:0033523)2.72194516
77DNA synthesis involved in DNA repair (GO:0000731)2.70674692
78regulation of DNA endoreduplication (GO:0032875)2.68450031
79myelin maintenance (GO:0043217)2.67551787
80positive regulation of cell cycle checkpoint (GO:1901978)2.66767324
81L-amino acid import (GO:0043092)2.66610102
82cortical actin cytoskeleton organization (GO:0030866)2.66445103
83DNA geometric change (GO:0032392)2.65953361
84asymmetric protein localization (GO:0008105)2.64887340
85regulation of centrosome cycle (GO:0046605)2.64653232
86regulation of Rap GTPase activity (GO:0032317)2.63829797
87cortical cytoskeleton organization (GO:0030865)2.62321287
88negative regulation of DNA recombination (GO:0045910)2.61776961
89peptidyl-threonine modification (GO:0018210)2.60207437
90attachment of spindle microtubules to kinetochore (GO:0008608)2.58912383
91detection of molecule of bacterial origin (GO:0032490)2.58308064
92RNA stabilization (GO:0043489)2.58110066
93mRNA stabilization (GO:0048255)2.58110066
94positive regulation of Rap GTPase activity (GO:0032854)2.56613408
95presynaptic membrane assembly (GO:0097105)2.56243146
96mitotic recombination (GO:0006312)2.55829902
97regulation of mitotic spindle organization (GO:0060236)2.55578188
98regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.54542727
99peptidyl-threonine phosphorylation (GO:0018107)2.53365141
100synaptic vesicle exocytosis (GO:0016079)2.51342839
101response to peptidoglycan (GO:0032494)2.49469463
102negative regulation of B cell proliferation (GO:0030889)2.49363791
103labyrinthine layer development (GO:0060711)2.48887439
104DNA ligation (GO:0006266)2.48758416
105protein complex localization (GO:0031503)2.47869985
106regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.47744750
107CENP-A containing nucleosome assembly (GO:0034080)2.45568895
108embryonic process involved in female pregnancy (GO:0060136)2.44999711
109histone H3-K9 demethylation (GO:0033169)2.44437608
110DNA strand elongation involved in DNA replication (GO:0006271)2.43424609
111eye photoreceptor cell differentiation (GO:0001754)2.43254160
112photoreceptor cell differentiation (GO:0046530)2.43254160
113neuronal action potential propagation (GO:0019227)2.42595927
114cytoskeleton-dependent cytokinesis (GO:0061640)2.41856363
115kinetochore organization (GO:0051383)2.41471151
116protein localization to chromosome (GO:0034502)2.41238478
117telomere maintenance via recombination (GO:0000722)2.39554601
118nucleus organization (GO:0006997)2.39376801
119DNA strand elongation (GO:0022616)2.38411849
120long-term synaptic potentiation (GO:0060291)2.38409127
121DNA conformation change (GO:0071103)2.38252388
122N-terminal protein amino acid acetylation (GO:0006474)2.38135179
123regulation of synaptic vesicle exocytosis (GO:2000300)2.36834059
124apical protein localization (GO:0045176)2.36756193
125presynaptic membrane organization (GO:0097090)2.32417633
126regulation of voltage-gated calcium channel activity (GO:1901385)2.30371527
127fatty acid elongation (GO:0030497)2.29535364
128protein localization to endosome (GO:0036010)2.28924805
129neutrophil activation (GO:0042119)2.28282938
130regulated secretory pathway (GO:0045055)2.22611023
131positive regulation of actin filament depolymerization (GO:0030836)2.22465772
132negative regulation of axon extension (GO:0030517)2.20493285
133negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.19174885
134regulation of collateral sprouting (GO:0048670)2.16620210
135mast cell activation involved in immune response (GO:0002279)2.15481385
136mast cell degranulation (GO:0043303)2.15481385
137fucose catabolic process (GO:0019317)2.15383091
138L-fucose metabolic process (GO:0042354)2.15383091
139L-fucose catabolic process (GO:0042355)2.15383091
140neuron cell-cell adhesion (GO:0007158)2.14962985
141hypotonic response (GO:0006971)2.14721234
142vesicle transport along microtubule (GO:0047496)2.13762452
143transmission of nerve impulse (GO:0019226)2.13193346
144B cell receptor signaling pathway (GO:0050853)2.12726309
145Golgi to endosome transport (GO:0006895)2.11655371
146regulation of homotypic cell-cell adhesion (GO:0034110)2.11583118
147mast cell activation (GO:0045576)2.11182825
148antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.11133703
149ER overload response (GO:0006983)2.11089123
150gamma-aminobutyric acid signaling pathway (GO:0007214)2.10995849
151negative regulation of B cell activation (GO:0050869)2.10596379
152negative regulation of exocytosis (GO:0045920)2.09885933
153leukocyte degranulation (GO:0043299)2.08901577
154leukocyte aggregation (GO:0070486)2.08018800
155regulation of platelet aggregation (GO:0090330)2.07178499
156granulocyte activation (GO:0036230)2.07050318
157axonal fasciculation (GO:0007413)2.06559429
158mechanosensory behavior (GO:0007638)2.05105992
159magnesium ion transport (GO:0015693)2.04592742
160neuron recognition (GO:0008038)2.00690227
161response to nerve growth factor (GO:1990089)1.99608861
162cellular response to nerve growth factor stimulus (GO:1990090)1.99608861
163positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)1.98864400
164regulation of dendritic spine morphogenesis (GO:0061001)1.97303717
165dendrite morphogenesis (GO:0048813)1.96469487
166phosphatidylinositol dephosphorylation (GO:0046856)1.96066661
167regulation of neuron projection regeneration (GO:0070570)1.95217351
168regulation of axon regeneration (GO:0048679)1.95217351
169astrocyte development (GO:0014002)1.93850084
170amino acid import (GO:0043090)1.93780978
171histone H3-K4 trimethylation (GO:0080182)1.91993492
172regulation of amyloid precursor protein catabolic process (GO:1902991)1.91948651
173regulation of somitogenesis (GO:0014807)1.91425169
174auditory receptor cell differentiation (GO:0042491)1.91392035
175negative regulation of axonogenesis (GO:0050771)1.91175032
176negative regulation of synaptic transmission, GABAergic (GO:0032229)1.90332908
177lipid translocation (GO:0034204)1.89602810
178phospholipid translocation (GO:0045332)1.89602810
179activated T cell proliferation (GO:0050798)1.89075653
180synaptic vesicle maturation (GO:0016188)1.88616292
181regulation of beta-amyloid formation (GO:1902003)1.86602877
182protein localization to synapse (GO:0035418)1.85749700
183clathrin coat assembly (GO:0048268)1.85496763
184mesodermal cell differentiation (GO:0048333)1.84778535
185membrane assembly (GO:0071709)1.84245994
186hepatocyte apoptotic process (GO:0097284)1.83874316
187ionotropic glutamate receptor signaling pathway (GO:0035235)1.83653981
188negative regulation of cell killing (GO:0031342)1.82999823
189negative regulation of leukocyte mediated cytotoxicity (GO:0001911)1.82999823
190fucose metabolic process (GO:0006004)1.82015304
191synaptic transmission, dopaminergic (GO:0001963)1.79905260
192glutamate secretion (GO:0014047)1.79804753
193peripheral nervous system development (GO:0007422)1.79179502
194leukocyte migration involved in inflammatory response (GO:0002523)1.79082977
195B cell homeostasis (GO:0001782)1.79007832

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.50942989
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.24938727
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.73072863
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.58217443
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.39696698
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.14793704
7AR_21909140_ChIP-Seq_LNCAP_Human3.14012819
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.02287150
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.89968565
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.84339518
11GBX2_23144817_ChIP-Seq_PC3_Human2.73483186
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.44161856
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28068833
14TAF15_26573619_Chip-Seq_HEK293_Human2.26127911
15* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.25319422
16* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.18236660
17FUS_26573619_Chip-Seq_HEK293_Human2.17332813
18GATA1_22025678_ChIP-Seq_K562_Human2.15674962
19WT1_19549856_ChIP-ChIP_CCG9911_Human1.94255898
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84764218
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.83903795
22ER_23166858_ChIP-Seq_MCF-7_Human1.82907117
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82035481
24* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.75974991
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74269944
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.73988864
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.72415542
28SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.71859524
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.70735149
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70382812
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68638670
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.66493399
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.65735226
34P300_19829295_ChIP-Seq_ESCs_Human1.65638160
35ELK1_19687146_ChIP-ChIP_HELA_Human1.64286173
36TP53_16413492_ChIP-PET_HCT116_Human1.63192059
37SMAD4_21799915_ChIP-Seq_A2780_Human1.57220836
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.56832411
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56240707
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.55665371
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.54324055
42SALL4_18804426_ChIP-ChIP_XEN_Mouse1.53540411
43EWS_26573619_Chip-Seq_HEK293_Human1.52353607
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51557321
45* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51006862
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50992270
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49768694
48* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49022054
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48970888
50RUNX_20019798_ChIP-Seq_JUKART_Human1.48109770
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47180779
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.46623525
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.46623525
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.45967393
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.45140412
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44387644
57* SMAD3_21741376_ChIP-Seq_EPCs_Human1.44236611
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43722904
59AHR_22903824_ChIP-Seq_MCF-7_Human1.43699441
60* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41521889
61NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38322722
62AR_21572438_ChIP-Seq_LNCaP_Human1.37803887
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36891055
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36146431
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33347288
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31570278
67* STAT3_23295773_ChIP-Seq_U87_Human1.30163048
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30019002
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28852483
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.27859471
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26246740
72* BRD4_25478319_ChIP-Seq_HGPS_Human1.25999604
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25719116
74TP53_18474530_ChIP-ChIP_U2OS_Human1.25216317
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25112164
76FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24958119
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24591905
78NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24531580
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24161935
80* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.22280576
81* IRF8_27001747_Chip-Seq_BMDM_Mouse1.20872420
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.20530970
83SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20436677
84* TCF4_23295773_ChIP-Seq_U87_Human1.19846014
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.17862025
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17706973
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17009427
88SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17009427
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16925372
90VDR_24787735_ChIP-Seq_THP-1_Human1.16597332
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.15591422
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15275705
93NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14691698
94* CHD1_26751641_Chip-Seq_LNCaP_Human1.14477391
95CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14383231
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.13559630
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13418509
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12801805
99ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12795051
100RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12767818
101EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12767818
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12124369
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12005931
104MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11374088
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11184827
106TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11043043
107CLOCK_20551151_ChIP-Seq_293T_Human1.10491744
108SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10276572
109SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10092105
110EZH2_22144423_ChIP-Seq_EOC_Human1.10076787
111AR_25329375_ChIP-Seq_VCAP_Human1.09827626
112RARB_27405468_Chip-Seq_BRAIN_Mouse1.09510303
113CMYC_18555785_Chip-Seq_ESCs_Mouse1.09235619
114PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08636571
115SOX2_21211035_ChIP-Seq_LN229_Gbm1.08204254
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08155127
117E2F1_18555785_Chip-Seq_ESCs_Mouse1.07802280
118FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07471826
119JUN_21703547_ChIP-Seq_K562_Human1.05416649
120P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04927718
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04793356
122MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03350947
123RXR_22108803_ChIP-Seq_LS180_Human1.03332425
124P53_22387025_ChIP-Seq_ESCs_Mouse1.02288832
125PU_27001747_Chip-Seq_BMDM_Mouse1.02251088
126RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01896047
127RNF2_27304074_Chip-Seq_ESCs_Mouse1.00313271
128SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99859726
129DROSHA_22980978_ChIP-Seq_HELA_Human0.99710054
130RUNX2_22187159_ChIP-Seq_PCA_Human0.99475727
131SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99034257
132IGF1R_20145208_ChIP-Seq_DFB_Human0.97881535
133CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97347235
134MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97248483
135YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97209734
136BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97030208
137YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96985436
138WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96768094
139UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96596635
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96305791
141NELFA_20434984_ChIP-Seq_ESCs_Mouse0.96113089
142CJUN_26792858_Chip-Seq_BT549_Human0.96067088
143HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95368250
144MYC_18555785_ChIP-Seq_MESCs_Mouse0.94061611
145EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92649302
146SPI1_23547873_ChIP-Seq_NB4_Human0.90129871
147TFEB_21752829_ChIP-Seq_HELA_Human0.89425047
148POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89178658
149TCF4_18268006_ChIP-ChIP_LS174T_Human0.88787848
150FOXO3_23340844_ChIP-Seq_DLD1_Human0.85738698
151EZH2_27294783_Chip-Seq_NPCs_Mouse0.84493484
152STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83626936
153CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.82865933
154PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81863829
155FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.81646213
156ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81470239
157EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81303418
158NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.80936143
159SOX17_20123909_ChIP-Seq_XEN_Mouse0.80460247
160* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80334240
161P300_18555785_Chip-Seq_ESCs_Mouse0.79380895

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.66913849
2MP0010352_gastrointestinal_tract_polyps3.75727471
3MP0003880_abnormal_central_pattern2.90358030
4MP0004859_abnormal_synaptic_plasticity2.82648592
5MP0000920_abnormal_myelination2.80416352
6MP0002877_abnormal_melanocyte_morpholog2.74376822
7MP0010094_abnormal_chromosome_stability2.70097344
8MP0004957_abnormal_blastocyst_morpholog2.66995526
9MP0004270_analgesia2.46422961
10MP0003077_abnormal_cell_cycle2.35204207
11MP0003890_abnormal_embryonic-extraembry2.27036317
12MP0003705_abnormal_hypodermis_morpholog2.26945224
13MP0008260_abnormal_autophagy2.21929576
14MP0003221_abnormal_cardiomyocyte_apopto2.21744087
15MP0002009_preneoplasia2.21060092
16MP0003111_abnormal_nucleus_morphology2.19230717
17MP0010307_abnormal_tumor_latency2.16571401
18MP0001485_abnormal_pinna_reflex2.14764835
19MP0005248_abnormal_Harderian_gland2.01242285
20MP0004134_abnormal_chest_morphology1.90164668
21MP0003828_pulmonary_edema1.90104722
22MP0003787_abnormal_imprinting1.82945006
23MP0005076_abnormal_cell_differentiation1.81316173
24MP0003566_abnormal_cell_adhesion1.78203185
25MP0000350_abnormal_cell_proliferation1.72409546
26MP0000569_abnormal_digit_pigmentation1.68554776
27MP0004185_abnormal_adipocyte_glucose1.67946973
28MP0002064_seizures1.62531434
29MP0003635_abnormal_synaptic_transmissio1.60965454
30MP0003693_abnormal_embryo_hatching1.60433501
31MP0001958_emphysema1.58791676
32MP0008932_abnormal_embryonic_tissue1.57473320
33MP0001835_abnormal_antigen_presentation1.56557570
34MP0004808_abnormal_hematopoietic_stem1.55414507
35MP0005623_abnormal_meninges_morphology1.53814833
36MP0006054_spinal_hemorrhage1.51728745
37MP0002272_abnormal_nervous_system1.50944198
38MP0001730_embryonic_growth_arrest1.50208620
39MP0004742_abnormal_vestibular_system1.49128965
40MP0001963_abnormal_hearing_physiology1.48774720
41MP0010678_abnormal_skin_adnexa1.47577610
42MP0003941_abnormal_skin_development1.45677118
43MP0000778_abnormal_nervous_system1.44204206
44MP0003984_embryonic_growth_retardation1.43416715
45MP0009745_abnormal_behavioral_response1.43015112
46MP0001672_abnormal_embryogenesis/_devel1.42283834
47MP0005380_embryogenesis_phenotype1.42283834
48MP0002088_abnormal_embryonic_growth/wei1.40726119
49MP0002734_abnormal_mechanical_nocicepti1.40264355
50MP0001968_abnormal_touch/_nociception1.39596104
51MP0001299_abnormal_eye_distance/1.38819761
52MP0003690_abnormal_glial_cell1.37877855
53MP0003300_gastrointestinal_ulcer1.36284796
54MP0004885_abnormal_endolymph1.35370660
55MP0009780_abnormal_chondrocyte_physiolo1.34330932
56MP0001486_abnormal_startle_reflex1.34195535
57MP0002063_abnormal_learning/memory/cond1.32832251
58MP0005310_abnormal_salivary_gland1.31806395
59MP0002166_altered_tumor_susceptibility1.30992441
60MP0003303_peritoneal_inflammation1.29478077
61MP0001697_abnormal_embryo_size1.29360330
62MP0008058_abnormal_DNA_repair1.29306418
63MP0005621_abnormal_cell_physiology1.29037810
64MP0004197_abnormal_fetal_growth/weight/1.28999973
65MP0009046_muscle_twitch1.28285425
66MP0002086_abnormal_extraembryonic_tissu1.27719526
67MP0002735_abnormal_chemical_nociception1.24659420
68MP0005409_darkened_coat_color1.23779521
69MP0000427_abnormal_hair_cycle1.23448897
70MP0002736_abnormal_nociception_after1.22453459
71MP0003091_abnormal_cell_migration1.22115160
72MP0002084_abnormal_developmental_patter1.21972044
73MP0003634_abnormal_glial_cell1.20826798
74MP0008007_abnormal_cellular_replicative1.20101762
75MP0008569_lethality_at_weaning1.19582230
76MP0004484_altered_response_of1.17672800
77MP0002006_tumorigenesis1.17335709
78MP0003879_abnormal_hair_cell1.17292106
79MP0009697_abnormal_copulation1.16548309
80MP0005171_absent_coat_pigmentation1.14166849
81MP0005058_abnormal_lysosome_morphology1.12219069
82MP0000428_abnormal_craniofacial_morphol1.11709251
83MP0005000_abnormal_immune_tolerance1.10904485
84MP0000383_abnormal_hair_follicle1.10857108
85MP0005384_cellular_phenotype1.10803845
86MP0003632_abnormal_nervous_system1.10436992
87MP0002080_prenatal_lethality1.10161990
88MP0002396_abnormal_hematopoietic_system1.09871681
89MP0004883_abnormal_blood_vessel1.09585226
90MP0003172_abnormal_lysosome_physiology1.08924279
91MP0002572_abnormal_emotion/affect_behav1.07553106
92MP0000537_abnormal_urethra_morphology1.06702951
93MP0003045_fibrosis1.06397781
94MP0005387_immune_system_phenotype1.05968610
95MP0001790_abnormal_immune_system1.05968610
96MP0001905_abnormal_dopamine_level1.05485121
97MP0002148_abnormal_hypersensitivity_rea1.05228207
98MP0003191_abnormal_cellular_cholesterol1.02953106
99MP0002085_abnormal_embryonic_tissue1.02870605
100MP0001346_abnormal_lacrimal_gland1.02768588
101MP0002067_abnormal_sensory_capabilities1.02219769
102MP0001348_abnormal_lacrimal_gland1.01597498
103MP0000579_abnormal_nail_morphology1.01423011
104MP0001851_eye_inflammation1.00792861
105MP0002452_abnormal_antigen_presenting1.00610083
106MP0009703_decreased_birth_body1.00259101
107MP0005671_abnormal_response_to0.99624978
108MP0001849_ear_inflammation0.99368239
109MP0003656_abnormal_erythrocyte_physiolo0.98979529
110MP0009672_abnormal_birth_weight0.98742482
111MP0003453_abnormal_keratinocyte_physiol0.98489780
112MP0003633_abnormal_nervous_system0.98162225
113MP0003631_nervous_system_phenotype0.97747022
114MP0001177_atelectasis0.97743485
115MP0008004_abnormal_stomach_pH0.96702867
116MP0004272_abnormal_basement_membrane0.95927125
117MP0000313_abnormal_cell_death0.95076887
118MP0002420_abnormal_adaptive_immunity0.94244231
119MP0001800_abnormal_humoral_immune0.94163308
120MP0008438_abnormal_cutaneous_collagen0.92130367
121MP0010234_abnormal_vibrissa_follicle0.92053397
122MP0001819_abnormal_immune_cell0.91857389
123MP0002092_abnormal_eye_morphology0.91339715
124MP0001915_intracranial_hemorrhage0.88078526
125MP0004043_abnormal_pH_regulation0.86707855
126MP0001970_abnormal_pain_threshold0.84016174
127MP0001765_abnormal_ion_homeostasis0.83486815
128MP0003943_abnormal_hepatobiliary_system0.83334400
129MP0002419_abnormal_innate_immunity0.83320368
130MP0002882_abnormal_neuron_morphology0.82847753
131MP0001440_abnormal_grooming_behavior0.82753508
132MP0005377_hearing/vestibular/ear_phenot0.82563417
133MP0003878_abnormal_ear_physiology0.82563417
134MP0000377_abnormal_hair_follicle0.82423133
135MP0003329_amyloid_beta_deposits0.82261897
136MP0001191_abnormal_skin_condition0.80260237
137MP0002229_neurodegeneration0.79469867
138MP0001188_hyperpigmentation0.78942220
139MP0002060_abnormal_skin_morphology0.78580506
140MP0000358_abnormal_cell_content/0.78400210
141MP0004924_abnormal_behavior0.78277794
142MP0005386_behavior/neurological_phenoty0.78277794
143MP0003950_abnormal_plasma_membrane0.78151653
144MP0002723_abnormal_immune_serum0.77000742
145MP0002133_abnormal_respiratory_system0.76778520
146MP0005388_respiratory_system_phenotype0.76778520
147MP0004811_abnormal_neuron_physiology0.76483784
148MP0003937_abnormal_limbs/digits/tail_de0.76346736
149MP0000026_abnormal_inner_ear0.76262746
150MP0001293_anophthalmia0.75337433
151MP0000955_abnormal_spinal_cord0.72853367
152MP0003183_abnormal_peptide_metabolism0.72607065
153MP0002697_abnormal_eye_size0.72428490
154MP0000490_abnormal_crypts_of0.71786342
155MP0002925_abnormal_cardiovascular_devel0.71722036
156MP0003121_genomic_imprinting0.71306264
157MP0004264_abnormal_extraembryonic_tissu0.71263080
158MP0000015_abnormal_ear_pigmentation0.71063545
159MP0002090_abnormal_vision0.71037152
160MP0000465_gastrointestinal_hemorrhage0.70488886
161MP0005174_abnormal_tail_pigmentation0.70196089
162MP0002933_joint_inflammation0.69694638
163MP0010386_abnormal_urinary_bladder0.69270520
164MP0002796_impaired_skin_barrier0.69046627
165MP0001286_abnormal_eye_development0.68772701
166MP0003448_altered_tumor_morphology0.68525642
167MP0003724_increased_susceptibility_to0.67642326
168MP0000432_abnormal_head_morphology0.67466295
169MP0002733_abnormal_thermal_nociception0.66775653
170MP0001529_abnormal_vocalization0.66663099
171MP0005164_abnormal_response_to0.64070535
172MP0003115_abnormal_respiratory_system0.63339101
173MP0005666_abnormal_adipose_tissue0.62483395
174MP0001216_abnormal_epidermal_layer0.62347565
175MP0010630_abnormal_cardiac_muscle0.61471048

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)4.32005753
2Epiphyseal dysplasia (HP:0002656)4.12963223
3Degeneration of the lateral corticospinal tracts (HP:0002314)3.73724740
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.73724740
5Termporal pattern (HP:0011008)3.71733274
6Insidious onset (HP:0003587)3.71733274
7Curly hair (HP:0002212)3.19054797
8Cortical dysplasia (HP:0002539)3.11153573
9Mixed hearing impairment (HP:0000410)3.04794344
10Ankyloglossia (HP:0010296)3.04437424
11Thyroid carcinoma (HP:0002890)3.00713600
12Deep philtrum (HP:0002002)2.95894641
13Transitional cell carcinoma of the bladder (HP:0006740)2.89602971
14Absent frontal sinuses (HP:0002688)2.84883503
15Volvulus (HP:0002580)2.81343359
16Rhabdomyosarcoma (HP:0002859)2.79945880
17Bladder neoplasm (HP:0009725)2.78925117
18Bladder carcinoma (HP:0002862)2.78925117
19Acute myeloid leukemia (HP:0004808)2.75618022
20Abnormality of chromosome stability (HP:0003220)2.74061528
21Subacute progressive viral hepatitis (HP:0006572)2.63644084
22Leiomyosarcoma (HP:0100243)2.59318822
23Uterine leiomyosarcoma (HP:0002891)2.59318822
24Medulloblastoma (HP:0002885)2.58107239
25Gastrointestinal carcinoma (HP:0002672)2.55930540
26Malignant gastrointestinal tract tumors (HP:0006749)2.55930540
27Abnormality of the corticospinal tract (HP:0002492)2.52949177
28Missing ribs (HP:0000921)2.52152099
29Cystic hygroma (HP:0000476)2.49528405
30Increased circulating renin level (HP:0000848)2.49210413
31Hypomagnesemia (HP:0002917)2.47239513
32Chromsome breakage (HP:0040012)2.46484753
33Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.44270057
34Enlarged epiphyses (HP:0010580)2.42171831
35Small epiphyses (HP:0010585)2.40027633
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.37295308
37Agnosia (HP:0010524)2.35989232
38Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.35860791
39Vertebral arch anomaly (HP:0008438)2.35599325
40Widely spaced teeth (HP:0000687)2.33133584
41Abnormal hair whorl (HP:0010721)2.28510713
42Peripheral hypomyelination (HP:0007182)2.26409220
43Large earlobe (HP:0009748)2.25993900
44Papilledema (HP:0001085)2.24374174
45Atonic seizures (HP:0010819)2.24288206
46Macroorchidism (HP:0000053)2.22985067
47Osteolytic defects of the hand bones (HP:0009699)2.21241825
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.21241825
49Abnormality of oral frenula (HP:0000190)2.19497771
50Nephroblastoma (Wilms tumor) (HP:0002667)2.19184895
51Biliary tract neoplasm (HP:0100574)2.19002140
52Abnormal auditory evoked potentials (HP:0006958)2.18853799
53Metaphyseal dysplasia (HP:0100255)2.18500106
54Mild short stature (HP:0003502)2.15724571
55Metabolic alkalosis (HP:0200114)2.13466096
56Embryonal renal neoplasm (HP:0011794)2.13370894
57Abnormality of chromosome segregation (HP:0002916)2.13341521
58Epileptic encephalopathy (HP:0200134)2.11787549
59Lower limb hyperreflexia (HP:0002395)2.10408700
60Abnormality of the frontal sinuses (HP:0002687)2.09062879
61Pheochromocytoma (HP:0002666)2.06866262
62Sandal gap (HP:0001852)2.06007064
63Resting tremor (HP:0002322)2.05081411
64Uterine neoplasm (HP:0010784)2.04382079
65Neoplasm of the small intestine (HP:0100833)2.02395699
66Neoplasm of striated muscle (HP:0009728)2.02261456
67Focal motor seizures (HP:0011153)2.01739529
68Sensory axonal neuropathy (HP:0003390)2.01587385
69Arterial tortuosity (HP:0005116)2.00780898
70Abnormality of the left ventricular outflow tract (HP:0011103)1.99566733
71Subaortic stenosis (HP:0001682)1.99566733
72Abnormality of incisor morphology (HP:0011063)1.99497288
73Selective tooth agenesis (HP:0001592)1.98328228
74Abnormal vertebral ossification (HP:0100569)1.97199641
75Abnormality of the distal phalanx of the thumb (HP:0009617)1.96458189
76Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.96337846
77Vascular tortuosity (HP:0004948)1.93598607
78Aqueductal stenosis (HP:0002410)1.93111146
79Increased nuchal translucency (HP:0010880)1.92542794
80Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91970078
81Irregular epiphyses (HP:0010582)1.91048082
82Cafe-au-lait spot (HP:0000957)1.90568263
83Neurofibrillary tangles (HP:0002185)1.89300341
84Hypoplastic pelvis (HP:0008839)1.89216594
85Agammaglobulinemia (HP:0004432)1.89084222
86Difficulty running (HP:0009046)1.88757008
87Milia (HP:0001056)1.87140332
88Spastic diplegia (HP:0001264)1.84372341
89Autoamputation (HP:0001218)1.84270275
90Delayed epiphyseal ossification (HP:0002663)1.84103057
91Myelodysplasia (HP:0002863)1.82678547
92Viral hepatitis (HP:0006562)1.82516020
93Absent epiphyses (HP:0010577)1.81902383
94Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.81902383
95Abnormal biliary tract morphology (HP:0012440)1.81495232
96Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81314434
97Short 4th metacarpal (HP:0010044)1.81314434
98Pulmonic stenosis (HP:0001642)1.80822046
99Freckling (HP:0001480)1.80577595
100Cubitus valgus (HP:0002967)1.80519127
101Abnormality of B cell number (HP:0010975)1.79897176
102B lymphocytopenia (HP:0010976)1.79897176
103Scanning speech (HP:0002168)1.79212142
104Eczematoid dermatitis (HP:0000976)1.79123324
105Abnormality of the hip-girdle musculature (HP:0001445)1.79000744
106Abnormality of the musculature of the pelvis (HP:0001469)1.79000744
107Onion bulb formation (HP:0003383)1.78680128
108Spontaneous hematomas (HP:0007420)1.78494385
109Cupped ear (HP:0000378)1.76657479
110Overlapping toe (HP:0001845)1.76025458
111Pelvic girdle muscle weakness (HP:0003749)1.75817497
112Cellulitis (HP:0100658)1.75596607
113Segmental peripheral demyelination/remyelination (HP:0003481)1.75016971
114Ovarian neoplasm (HP:0100615)1.74953820
115Progressive external ophthalmoplegia (HP:0000590)1.74804198
116Hypoplastic ischia (HP:0003175)1.74769861
11711 pairs of ribs (HP:0000878)1.74641215
118Recurrent pneumonia (HP:0006532)1.73993791
119Thick nail (HP:0001805)1.73881113
120Spastic gait (HP:0002064)1.73133993
121Anomalous pulmonary venous return (HP:0010772)1.72751773
122Periodontitis (HP:0000704)1.71454186
123Hip dysplasia (HP:0001385)1.71156420
124Truncal ataxia (HP:0002078)1.70931912
125Orthostatic hypotension (HP:0001278)1.70497080
126Neoplasm of the thyroid gland (HP:0100031)1.70428467
127Syringomyelia (HP:0003396)1.68985848
128Spinal cord lesions (HP:0100561)1.68985848
129Low anterior hairline (HP:0000294)1.68916064
130Inappropriate behavior (HP:0000719)1.67514143
131Long clavicles (HP:0000890)1.67132435
132Slow saccadic eye movements (HP:0000514)1.65620594
133Fibrous tissue neoplasm (HP:0012316)1.65433272
134Thickened helices (HP:0000391)1.65230752
135Cerebral inclusion bodies (HP:0100314)1.65118450
136Hypoplastic labia majora (HP:0000059)1.63867224
137Thyroiditis (HP:0100646)1.63457441
138Persistence of primary teeth (HP:0006335)1.63133106
139Glioma (HP:0009733)1.61438936
140Hypokalemic alkalosis (HP:0001949)1.61375671
141Hypoplasia of the iris (HP:0007676)1.60802761
142Deviation of the thumb (HP:0009603)1.58950351
143Abnormality of the vasculature of the conjunctiva (HP:0008054)1.58901546
144Relative macrocephaly (HP:0004482)1.58831210
145Recurrent bacterial skin infections (HP:0005406)1.58454669
146Bell-shaped thorax (HP:0001591)1.58017855
147Recurrent viral infections (HP:0004429)1.57719368
148Spondylolisthesis (HP:0003302)1.57646684
149Abnormality of magnesium homeostasis (HP:0004921)1.57631139
150Gastrointestinal stroma tumor (HP:0100723)1.57516221
151Supranuclear gaze palsy (HP:0000605)1.56483487
152Diplopia (HP:0000651)1.56268701
153Abnormality of binocular vision (HP:0011514)1.56268701
154Barrel-shaped chest (HP:0001552)1.56082952
155Abnormality of the pulmonary veins (HP:0011718)1.56036789
156Focal seizures (HP:0007359)1.55959471
157Broad-based gait (HP:0002136)1.55784643
158Abnormality of the nasal septum (HP:0000419)1.55478799
159Intention tremor (HP:0002080)1.54669796
160Lower limb muscle weakness (HP:0007340)1.53222439
161Abnormality of the ischium (HP:0003174)1.53019179
162Abnormality of the phalanges of the 2nd finger (HP:0009541)1.52383944
163Morphological abnormality of the inner ear (HP:0011390)1.51826156
164Alacrima (HP:0000522)1.49175920
165Abnormality of cochlea (HP:0000375)1.49165223
166Abnormality of the 2nd finger (HP:0004100)1.46569118
167Limited elbow extension (HP:0001377)1.45646058
168Dysmetria (HP:0001310)1.44328921
169Asymmetry of the thorax (HP:0001555)1.43533357
170Disinhibition (HP:0000734)1.42829499
171Disproportionate short-trunk short stature (HP:0003521)1.42586283
172Abnormal drinking behavior (HP:0030082)1.42128043
173Polydipsia (HP:0001959)1.42128043
174Akinesia (HP:0002304)1.41885010
175Infantile muscular hypotonia (HP:0008947)1.41799440
176Action tremor (HP:0002345)1.41214623
177Hypoplasia of the odontoid process (HP:0003311)1.41143988
178Recurrent abscess formation (HP:0002722)1.40277841
179Decreased lacrimation (HP:0000633)1.40171025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.88896661
2OXSR13.84484208
3EPHB13.28092116
4DDR23.00986189
5MST42.77006835
6MKNK22.60078907
7WNK42.59657676
8RIPK42.47273286
9WEE12.28918291
10SRPK12.20800735
11WNK12.14047340
12PBK2.12482489
13KSR12.06298610
14BCR2.04434769
15TTK2.03057650
16TSSK61.97406680
17STK241.89825686
18MAPKAPK51.86388428
19TNIK1.75270162
20MAP3K61.74121484
21EIF2AK11.73140475
22MKNK11.71465925
23NEK11.70362192
24CDK61.70081870
25PLK21.68718626
26CDC71.68584053
27BRSK21.58194835
28MAP3K101.57701514
29EPHA41.56135393
30PLK41.55991569
31CLK11.55921291
32TRPM71.54847542
33NEK91.53066672
34ERBB31.52702206
35LATS11.50674929
36CSNK1A1L1.50607565
37RPS6KA41.49327731
38CDK191.48635102
39FGR1.48474560
40FES1.48447169
41KSR21.46335309
42BMPR21.44969147
43STK31.44712496
44TRIM281.34508932
45MAP2K31.33059334
46TAF11.32669036
47NTRK31.30930290
48STK38L1.28221054
49MAP3K141.27577367
50ACVR1B1.26862183
51CASK1.22492497
52UHMK11.22426272
53MAP3K131.21918537
54CSNK1G31.21722011
55PRKCQ1.21527706
56PNCK1.21351269
57MAP3K21.20446776
58NTRK11.20207295
59CSNK1G21.10502797
60DYRK31.10084600
61PDGFRA1.10017381
62ALK1.09036844
63PKN11.07218450
64LATS21.07075742
65ROCK21.06800330
66TEC1.06371216
67MAP2K41.04612177
68MAP3K41.04166638
69SGK4941.02060463
70SGK2231.02060463
71YES11.01146265
72LIMK11.01138991
73BUB11.00555636
74FGFR20.97331577
75FRK0.92644564
76MAP3K120.91622761
77STK100.89716156
78AKT30.89249574
79MAP2K70.88986068
80CSNK1G10.87207381
81NEK60.86826525
82IRAK40.83918989
83DMPK0.83572437
84EIF2AK20.82854437
85EPHA30.82441188
86MST1R0.82383805
87CDK50.82371081
88PRPF4B0.78718553
89CAMK1D0.77651387
90FGFR10.77595665
91CSF1R0.77328505
92RAF10.76295248
93MAPK130.75922730
94PLK30.72162305
95ITK0.71951315
96TNK20.70870983
97KIT0.69887824
98DAPK20.69083649
99MET0.68961519
100WNK30.68815551
101MELK0.68184331
102BTK0.66442063
103CDK120.66295453
104FYN0.66009672
105CAMKK20.65998323
106JAK30.65703896
107LRRK20.64848039
108PTK2B0.64634256
109SGK10.62499294
110JAK10.62352050
111TYK20.62072212
112NUAK10.61660937
113RET0.61659249
114TGFBR10.61490788
115MAP3K90.61033513
116SYK0.60818833
117JAK20.60430661
118PAK40.60285668
119CHEK10.60263191
120BRD40.59652916
121HIPK20.59124065
122PDGFRB0.58745161
123PRKCE0.58258643
124EIF2AK30.57270877
125MINK10.56915905
126MOS0.56800576
127MARK30.56769963
128IRAK20.56715075
129BRAF0.55551938
130ERBB40.55509745
131PDK10.52599590
132ATM0.52427282
133PLK10.51797640
134PAK30.51355921
135SIK30.49244696
136CSK0.48769817
137LCK0.48143822
138PRKCH0.46852610
139MAP3K50.46309012
140MAP3K80.46306311
141SGK20.46141466
142STK40.44702374
143SIK20.44611540
144INSR0.44122763
145MAPK100.43740316
146CSNK1A10.42679735
147LYN0.42175772
148ATR0.41811393
149CAMK2B0.41347778
150CCNB10.40328989
151CAMK1G0.38885105
152PDPK10.38390226
153SCYL20.37764458
154SRC0.37520742
155ABL10.37389362
156FGFR30.37081938
157SGK30.36832555
158MAP4K10.36116643
159CDK140.35206907

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.35690815
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.99910574
3Cell cycle_Homo sapiens_hsa041101.96924665
4Mismatch repair_Homo sapiens_hsa034301.73419862
5Chronic myeloid leukemia_Homo sapiens_hsa052201.72146126
6Adherens junction_Homo sapiens_hsa045201.71288969
7Collecting duct acid secretion_Homo sapiens_hsa049661.59666789
8Thyroid cancer_Homo sapiens_hsa052161.59499263
9Non-small cell lung cancer_Homo sapiens_hsa052231.55345673
10Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.55325851
11Colorectal cancer_Homo sapiens_hsa052101.51174089
12DNA replication_Homo sapiens_hsa030301.50134685
13Endometrial cancer_Homo sapiens_hsa052131.48570430
14Long-term depression_Homo sapiens_hsa047301.44628307
15mRNA surveillance pathway_Homo sapiens_hsa030151.44506342
16Long-term potentiation_Homo sapiens_hsa047201.38611870
17RNA transport_Homo sapiens_hsa030131.33688675
18Serotonergic synapse_Homo sapiens_hsa047261.32165364
19Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.31524894
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29645758
21Vibrio cholerae infection_Homo sapiens_hsa051101.28183199
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.28087717
23Glutamatergic synapse_Homo sapiens_hsa047241.26501365
24Legionellosis_Homo sapiens_hsa051341.23838534
25B cell receptor signaling pathway_Homo sapiens_hsa046621.22949050
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21643248
27Morphine addiction_Homo sapiens_hsa050321.21319889
28Synaptic vesicle cycle_Homo sapiens_hsa047211.20948632
29Axon guidance_Homo sapiens_hsa043601.20595328
30Dopaminergic synapse_Homo sapiens_hsa047281.20449418
31Ether lipid metabolism_Homo sapiens_hsa005651.18972326
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18413977
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18083038
34Circadian entrainment_Homo sapiens_hsa047131.18056369
35Gastric acid secretion_Homo sapiens_hsa049711.17133805
36Oocyte meiosis_Homo sapiens_hsa041141.16604577
37Hepatitis B_Homo sapiens_hsa051611.12099400
38Small cell lung cancer_Homo sapiens_hsa052221.10193452
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09735598
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08398407
41FoxO signaling pathway_Homo sapiens_hsa040681.06760548
42Rheumatoid arthritis_Homo sapiens_hsa053231.06141071
43p53 signaling pathway_Homo sapiens_hsa041151.06043803
44ECM-receptor interaction_Homo sapiens_hsa045121.05925192
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04593532
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04179567
47Chemokine signaling pathway_Homo sapiens_hsa040621.03192272
48GABAergic synapse_Homo sapiens_hsa047271.02262786
49Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01901666
50Steroid biosynthesis_Homo sapiens_hsa001001.01366665
51Central carbon metabolism in cancer_Homo sapiens_hsa052301.00716526
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00573992
53Nicotine addiction_Homo sapiens_hsa050331.00562487
54Cholinergic synapse_Homo sapiens_hsa047251.00380629
55Phagosome_Homo sapiens_hsa041450.99128208
56Amphetamine addiction_Homo sapiens_hsa050310.96588879
57Shigellosis_Homo sapiens_hsa051310.96271816
58Spliceosome_Homo sapiens_hsa030400.96262581
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95906145
60Salivary secretion_Homo sapiens_hsa049700.95826694
61Primary immunodeficiency_Homo sapiens_hsa053400.95102235
62Renin secretion_Homo sapiens_hsa049240.94872015
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94617437
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.94554820
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94536808
66Prolactin signaling pathway_Homo sapiens_hsa049170.93976084
67mTOR signaling pathway_Homo sapiens_hsa041500.93318217
68Measles_Homo sapiens_hsa051620.92892831
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92846370
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92786040
71Olfactory transduction_Homo sapiens_hsa047400.91284524
72Gap junction_Homo sapiens_hsa045400.90566799
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90541995
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90143640
75Acute myeloid leukemia_Homo sapiens_hsa052210.90024899
76Salmonella infection_Homo sapiens_hsa051320.87156125
77Renal cell carcinoma_Homo sapiens_hsa052110.86023837
78Focal adhesion_Homo sapiens_hsa045100.85715079
79Pancreatic cancer_Homo sapiens_hsa052120.85512675
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85082752
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85050241
82Platelet activation_Homo sapiens_hsa046110.84936836
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84100263
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84038518
85HIF-1 signaling pathway_Homo sapiens_hsa040660.83305232
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.82830937
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82572190
88Cocaine addiction_Homo sapiens_hsa050300.82383589
89Viral carcinogenesis_Homo sapiens_hsa052030.82196706
90Osteoclast differentiation_Homo sapiens_hsa043800.80905763
91ErbB signaling pathway_Homo sapiens_hsa040120.80742293
92MAPK signaling pathway_Homo sapiens_hsa040100.80374386
93Fanconi anemia pathway_Homo sapiens_hsa034600.80374329
94Oxytocin signaling pathway_Homo sapiens_hsa049210.80230159
95Toxoplasmosis_Homo sapiens_hsa051450.80098346
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80010646
97Pathways in cancer_Homo sapiens_hsa052000.77247190
98Tuberculosis_Homo sapiens_hsa051520.76523091
99T cell receptor signaling pathway_Homo sapiens_hsa046600.75714181
100Leishmaniasis_Homo sapiens_hsa051400.75604791
101Amoebiasis_Homo sapiens_hsa051460.75556197
102Hematopoietic cell lineage_Homo sapiens_hsa046400.75462678
103Type I diabetes mellitus_Homo sapiens_hsa049400.75389631
104Glioma_Homo sapiens_hsa052140.75386930
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73951957
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72706588
107Endocytosis_Homo sapiens_hsa041440.72605832
108Dorso-ventral axis formation_Homo sapiens_hsa043200.72557437
109Bladder cancer_Homo sapiens_hsa052190.72345879
110Ras signaling pathway_Homo sapiens_hsa040140.72326659
111Allograft rejection_Homo sapiens_hsa053300.70636049
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70597158
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70279464
114Inositol phosphate metabolism_Homo sapiens_hsa005620.70133866
115GnRH signaling pathway_Homo sapiens_hsa049120.69955993
116Autoimmune thyroid disease_Homo sapiens_hsa053200.69436021
117Protein export_Homo sapiens_hsa030600.69258552
118Influenza A_Homo sapiens_hsa051640.68886944
119TGF-beta signaling pathway_Homo sapiens_hsa043500.68470491
120Choline metabolism in cancer_Homo sapiens_hsa052310.68317682
121Alcoholism_Homo sapiens_hsa050340.68172134
122Insulin signaling pathway_Homo sapiens_hsa049100.68145201
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67832098
124Melanoma_Homo sapiens_hsa052180.67648616
125Proteoglycans in cancer_Homo sapiens_hsa052050.67624018
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.67356266
127Viral myocarditis_Homo sapiens_hsa054160.65961124
128Sphingolipid metabolism_Homo sapiens_hsa006000.65013982
129MicroRNAs in cancer_Homo sapiens_hsa052060.64938590
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64917783
131Hippo signaling pathway_Homo sapiens_hsa043900.64649289
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.64177526
133Prostate cancer_Homo sapiens_hsa052150.63853014
134Lysosome_Homo sapiens_hsa041420.63688265
135Estrogen signaling pathway_Homo sapiens_hsa049150.63654984
136Nucleotide excision repair_Homo sapiens_hsa034200.63372877
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63296721
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62396269
139NF-kappa B signaling pathway_Homo sapiens_hsa040640.62086640
140Hepatitis C_Homo sapiens_hsa051600.62042477
141Rap1 signaling pathway_Homo sapiens_hsa040150.61189696
142Non-homologous end-joining_Homo sapiens_hsa034500.60535099
143Taste transduction_Homo sapiens_hsa047420.60156947
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60149236
145TNF signaling pathway_Homo sapiens_hsa046680.59956439
146Malaria_Homo sapiens_hsa051440.59801986
147Wnt signaling pathway_Homo sapiens_hsa043100.59758305
148Thyroid hormone synthesis_Homo sapiens_hsa049180.58747451
149Tight junction_Homo sapiens_hsa045300.58596973
150Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58569368
151VEGF signaling pathway_Homo sapiens_hsa043700.58299822
152RNA degradation_Homo sapiens_hsa030180.58174067
153Apoptosis_Homo sapiens_hsa042100.54797568
154Homologous recombination_Homo sapiens_hsa034400.54533864
155Melanogenesis_Homo sapiens_hsa049160.53905598

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