ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fucose catabolic process (GO:0019317)	4.43602708
2	L-fucose metabolic process (GO:0042354)	4.43602708
3	L-fucose catabolic process (GO:0042355)	4.43602708
4	nonmotile primary cilium assembly (GO:0035058)	4.15031311
5	somite development (GO:0061053)	4.06288381
6	indolalkylamine metabolic process (GO:0006586)	3.87424686
7	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.56811511
8	tryptophan catabolic process (GO:0006569)	3.47747263
9	indole-containing compound catabolic process (GO:0042436)	3.47747263
10	indolalkylamine catabolic process (GO:0046218)	3.47747263
11	reflex (GO:0060004)	3.47402547
12	behavioral response to nicotine (GO:0035095)	3.43678333
13	neural tube formation (GO:0001841)	3.34765863
14	adaptation of signaling pathway (GO:0023058)	3.33403727
15	cellular ketone body metabolic process (GO:0046950)	3.30161571
16	artery development (GO:0060840)	3.25502668
17	response to pheromone (GO:0019236)	3.24853473
18	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.22398644
19	kynurenine metabolic process (GO:0070189)	3.22349665
20	epithelial cilium movement (GO:0003351)	3.13603937
21	photoreceptor cell maintenance (GO:0045494)	3.12866325
22	nephron tubule morphogenesis (GO:0072078)	3.12210838
23	nephron epithelium morphogenesis (GO:0072088)	3.12210838
24	cilium or flagellum-dependent cell motility (GO:0001539)	3.05985758
25	tryptophan metabolic process (GO:0006568)	2.99550401
26	negative regulation of sodium ion transport (GO:0010766)	2.98676026
27	spinal cord motor neuron differentiation (GO:0021522)	2.97694742
28	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.95373019
29	righting reflex (GO:0060013)	2.93011952
30	ketone body metabolic process (GO:1902224)	2.90886542
31	monoubiquitinated protein deubiquitination (GO:0035520)	2.88075595
32	negative regulation of systemic arterial blood pressure (GO:0003085)	2.87675311
33	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.86332420
34	regulation of translation, ncRNA-mediated (GO:0045974)	2.86332420
35	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.86332420
36	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.85899919
37	detection of light stimulus involved in sensory perception (GO:0050962)	2.84811689
38	detection of light stimulus involved in visual perception (GO:0050908)	2.84811689
39	limb bud formation (GO:0060174)	2.84170240
40	indole-containing compound metabolic process (GO:0042430)	2.83230352
41	kidney morphogenesis (GO:0060993)	2.82908801
42	cellular response to sterol (GO:0036315)	2.78599888
43	cilium movement (GO:0003341)	2.78264448
44	synapsis (GO:0007129)	2.76460593
45	cilium organization (GO:0044782)	2.75394343
46	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.75023026
47	hindbrain development (GO:0030902)	2.72784850
48	cilium morphogenesis (GO:0060271)	2.71664406
49	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.70153770
50	retinal ganglion cell axon guidance (GO:0031290)	2.70048148
51	piRNA metabolic process (GO:0034587)	2.69392333
52	thalamus development (GO:0021794)	2.69068507
53	serotonin metabolic process (GO:0042428)	2.65508882
54	cilium assembly (GO:0042384)	2.64989650
55	DNA methylation involved in gamete generation (GO:0043046)	2.61951512
56	peptidyl-histidine modification (GO:0018202)	2.60654796
57	protein polyglutamylation (GO:0018095)	2.60598795
58	retina homeostasis (GO:0001895)	2.60594755
59	retinal metabolic process (GO:0042574)	2.60272980
60	regulation of gene silencing by miRNA (GO:0060964)	2.60172796
61	regulation of gene silencing by RNA (GO:0060966)	2.60172796
62	regulation of posttranscriptional gene silencing (GO:0060147)	2.60172796
63	positive regulation of glycolytic process (GO:0045821)	2.57813704
64	signal peptide processing (GO:0006465)	2.57745096
65	centriole replication (GO:0007099)	2.55915320
66	fucosylation (GO:0036065)	2.55780122
67	regulation of hippo signaling (GO:0035330)	2.55053541
68	prostate gland growth (GO:0060736)	2.54605022
69	short-term memory (GO:0007614)	2.53464341
70	mannosylation (GO:0097502)	2.53324272
71	biotin metabolic process (GO:0006768)	2.52492844
72	regulation of cilium movement (GO:0003352)	2.50935489
73	detection of temperature stimulus (GO:0016048)	2.50650825
74	primary amino compound metabolic process (GO:1901160)	2.48992632
75	regulation of mesoderm development (GO:2000380)	2.48285611
76	intraciliary transport (GO:0042073)	2.47913035
77	replication fork processing (GO:0031297)	2.46836726
78	amine catabolic process (GO:0009310)	2.46752793
79	cellular biogenic amine catabolic process (GO:0042402)	2.46752793
80	embryonic pattern specification (GO:0009880)	2.45957186
81	aromatic amino acid family catabolic process (GO:0009074)	2.44825957
82	behavioral response to ethanol (GO:0048149)	2.44345121
83	smoothened signaling pathway (GO:0007224)	2.42957890
84	pyrimidine nucleobase catabolic process (GO:0006208)	2.41716847
85	renal tubule morphogenesis (GO:0061333)	2.40793668
86	benzene-containing compound metabolic process (GO:0042537)	2.40443812
87	male meiosis (GO:0007140)	2.39733117
88	regulation of hexokinase activity (GO:1903299)	2.39722435
89	regulation of glucokinase activity (GO:0033131)	2.39722435
90	reciprocal DNA recombination (GO:0035825)	2.39712064
91	reciprocal meiotic recombination (GO:0007131)	2.39712064
92	dorsal/ventral neural tube patterning (GO:0021904)	2.39032734
93	transmission of nerve impulse (GO:0019226)	2.36028616
94	pancreas development (GO:0031016)	2.34851775
95	photoreceptor cell development (GO:0042461)	2.34591361
96	protein prenylation (GO:0018342)	2.34142878
97	prenylation (GO:0097354)	2.34142878
98	lung lobe morphogenesis (GO:0060463)	2.33193882
99	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.31079921
100	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.30504848

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.64140326
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.45463499
3	VDR_22108803_ChIP-Seq_LS180_Human	3.13363709
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.00603121
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.75293599
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.60717753
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.42208176
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.34809547
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.30671283
10	EWS_26573619_Chip-Seq_HEK293_Human	2.29879924
11	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.29565753
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.22896856
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.21128921
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.20442287
15	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.19677887
16	FUS_26573619_Chip-Seq_HEK293_Human	2.19499929
17	P300_19829295_ChIP-Seq_ESCs_Human	2.15705535
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.08698285
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.03360826
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.02865403
21	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.02499691
22	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.96136946
23	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.88379648
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.87643939
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.86073613
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.83342418
27	AR_21572438_ChIP-Seq_LNCaP_Human	1.80681882
28	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.76126580
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.67875861
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.67384697
31	STAT3_23295773_ChIP-Seq_U87_Human	1.67149308
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.66319708
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.65063234
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.62901025
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.59702913
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.58829078
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.58829078
38	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.56147188
39	TCF4_23295773_ChIP-Seq_U87_Human	1.53704260
40	AR_25329375_ChIP-Seq_VCAP_Human	1.53085382
41	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.52421593
42	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.51999989
43	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.50847130
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50380963
45	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.47232112
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.47022906
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.47017052
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.45300947
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44590570
50	RNF2_27304074_Chip-Seq_NSC_Mouse	1.42603126
51	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.41658719
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.40602591
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40602591
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39437113
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.35717024
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.32263427
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30425158
58	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.29374118
59	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.27365841
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26532055
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26532055
62	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.24041693
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23211767
64	TP53_22573176_ChIP-Seq_HFKS_Human	1.22449261
65	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.20880170
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.19731502
67	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.19307924
68	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.18555119
69	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17901749
70	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.17390076
71	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.14779733
72	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.12389046
73	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.10730611
74	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09183830
75	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.08210808
76	IRF1_19129219_ChIP-ChIP_H3396_Human	1.08172333
77	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06823535
78	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.05625389
79	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.05617114
80	CDX2_22108803_ChIP-Seq_LS180_Human	1.03972773
81	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.03529017
82	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.03013990
83	RXR_22108803_ChIP-Seq_LS180_Human	1.02995440
84	MYC_18940864_ChIP-ChIP_HL60_Human	1.02785114
85	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02140364
86	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02140364
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00898851
88	AHR_22903824_ChIP-Seq_MCF-7_Human	1.00834759
89	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00110768
90	P53_22387025_ChIP-Seq_ESCs_Mouse	0.99988227
91	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.99691617
92	REST_21632747_ChIP-Seq_MESCs_Mouse	0.99478586
93	AR_20517297_ChIP-Seq_VCAP_Human	0.98005196
94	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.96459923
95	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.96309468
96	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.95884557
97	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.95582190
98	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95555534
99	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.94996891
100	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94757173

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	2.90742095
2	MP0002234_abnormal_pharynx_morphology	2.78311391
3	MP0000569_abnormal_digit_pigmentation	2.69432164
4	MP0003195_calcinosis	2.53396887
5	MP0003011_delayed_dark_adaptation	2.46288384
6	MP0001968_abnormal_touch/_nociception	2.38213159
7	MP0002102_abnormal_ear_morphology	2.37199798
8	MP0004043_abnormal_pH_regulation	2.24640701
9	MP0005551_abnormal_eye_electrophysiolog	2.24365610
10	MP0002938_white_spotting	2.08583373
11	MP0003136_yellow_coat_color	2.08252588
12	MP0008877_abnormal_DNA_methylation	2.08166755
13	MP0002735_abnormal_chemical_nociception	2.01229642
14	MP0006292_abnormal_olfactory_placode	1.91320369
15	MP0003890_abnormal_embryonic-extraembry	1.85185613
16	MP0006072_abnormal_retinal_apoptosis	1.79036983
17	MP0005253_abnormal_eye_physiology	1.74789902
18	MP0001293_anophthalmia	1.68134479
19	MP0003122_maternal_imprinting	1.66032480
20	MP0005167_abnormal_blood-brain_barrier	1.55343290
21	MP0003283_abnormal_digestive_organ	1.55281547
22	MP0005646_abnormal_pituitary_gland	1.54876600
23	MP0008995_early_reproductive_senescence	1.53408967
24	MP0010030_abnormal_orbit_morphology	1.51582981
25	MP0000631_abnormal_neuroendocrine_gland	1.50854952
26	MP0009046_muscle_twitch	1.50220981
27	MP0000372_irregular_coat_pigmentation	1.45218711
28	MP0002090_abnormal_vision	1.42863534
29	MP0003937_abnormal_limbs/digits/tail_de	1.42188836
30	MP0001501_abnormal_sleep_pattern	1.40962366
31	MP0008057_abnormal_DNA_replication	1.40216988
32	MP0001485_abnormal_pinna_reflex	1.38148074
33	MP0006276_abnormal_autonomic_nervous	1.37277598
34	MP0000383_abnormal_hair_follicle	1.33767691
35	MP0003938_abnormal_ear_development	1.33284436
36	MP0002233_abnormal_nose_morphology	1.30537066
37	MP0004142_abnormal_muscle_tone	1.27957614
38	MP0000778_abnormal_nervous_system	1.22323303
39	MP0001984_abnormal_olfaction	1.20257524
40	MP0004742_abnormal_vestibular_system	1.20120322
41	MP0005085_abnormal_gallbladder_physiolo	1.20012390
42	MP0003119_abnormal_digestive_system	1.19613678
43	MP0000566_synostosis	1.19327082
44	MP0002733_abnormal_thermal_nociception	1.17651911
45	MP0002557_abnormal_social/conspecific_i	1.16295676
46	MP0001486_abnormal_startle_reflex	1.15523625
47	MP0003698_abnormal_male_reproductive	1.11762707
48	MP0003878_abnormal_ear_physiology	1.10929760
49	MP0005377_hearing/vestibular/ear_phenot	1.10929760
50	MP0005391_vision/eye_phenotype	1.10751390
51	MP0008789_abnormal_olfactory_epithelium	1.08946728
52	MP0002638_abnormal_pupillary_reflex	1.06868408
53	MP0008872_abnormal_physiological_respon	1.06839470
54	MP0003880_abnormal_central_pattern	1.06301099
55	MP0002751_abnormal_autonomic_nervous	1.06145992
56	MP0003718_maternal_effect	1.06093070
57	MP0002210_abnormal_sex_determination	1.05492769
58	MP0001970_abnormal_pain_threshold	1.05199942
59	MP0009745_abnormal_behavioral_response	1.05105232
60	MP0005408_hypopigmentation	1.04460232
61	MP0002160_abnormal_reproductive_system	1.04107298
62	MP0001286_abnormal_eye_development	1.02841165
63	MP0003121_genomic_imprinting	1.02517567
64	MP0002184_abnormal_innervation	1.01966553
65	MP0002272_abnormal_nervous_system	1.01669298
66	MP0005195_abnormal_posterior_eye	1.01354841
67	MP0001929_abnormal_gametogenesis	1.01111742
68	MP0000026_abnormal_inner_ear	1.00640984
69	MP0005645_abnormal_hypothalamus_physiol	0.99025571
70	MP0005174_abnormal_tail_pigmentation	0.98675172
71	MP0000427_abnormal_hair_cycle	0.98674187
72	MP0002752_abnormal_somatic_nervous	0.97916076
73	MP0002572_abnormal_emotion/affect_behav	0.97467858
74	MP0002067_abnormal_sensory_capabilities	0.96576979
75	MP0000049_abnormal_middle_ear	0.95752193
76	MP0003755_abnormal_palate_morphology	0.94779098
77	MP0004133_heterotaxia	0.93390654
78	MP0001324_abnormal_eye_pigmentation	0.93246565
79	MP0004924_abnormal_behavior	0.92517524
80	MP0005386_behavior/neurological_phenoty	0.92517524
81	MP0000955_abnormal_spinal_cord	0.92076438
82	MP0001529_abnormal_vocalization	0.91699874
83	MP0001986_abnormal_taste_sensitivity	0.89894714
84	MP0000613_abnormal_salivary_gland	0.89853083
85	MP0000653_abnormal_sex_gland	0.89644528
86	MP0001145_abnormal_male_reproductive	0.88377014
87	MP0005187_abnormal_penis_morphology	0.88194011
88	MP0003942_abnormal_urinary_system	0.87127624
89	MP0002734_abnormal_mechanical_nocicepti	0.86234243
90	MP0002653_abnormal_ependyma_morphology	0.84885142
91	MP0002837_dystrophic_cardiac_calcinosis	0.84823811
92	MP0002876_abnormal_thyroid_physiology	0.83768765
93	MP0003646_muscle_fatigue	0.83555690
94	MP0002282_abnormal_trachea_morphology	0.82711023
95	MP0002822_catalepsy	0.82153714
96	MP0008058_abnormal_DNA_repair	0.81711625
97	MP0002928_abnormal_bile_duct	0.81458227
98	MP0005410_abnormal_fertilization	0.80599436
99	MP0004145_abnormal_muscle_electrophysio	0.78411549
100	MP0003787_abnormal_imprinting	0.78336800

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.29684762
2	Pancreatic fibrosis (HP:0100732)	4.10111264
3	Abnormality of midbrain morphology (HP:0002418)	3.77033703
4	Molar tooth sign on MRI (HP:0002419)	3.77033703
5	True hermaphroditism (HP:0010459)	3.70910712
6	Nephronophthisis (HP:0000090)	3.51011035
7	Hyperventilation (HP:0002883)	3.29615182
8	Abnormality of the renal cortex (HP:0011035)	3.22194892
9	Abnormality of the renal medulla (HP:0100957)	3.19555550
10	Medial flaring of the eyebrow (HP:0010747)	3.09084449
11	Cystic liver disease (HP:0006706)	3.04232586
12	Tubular atrophy (HP:0000092)	2.89741453
13	Type II lissencephaly (HP:0007260)	2.85112229
14	Cerebellar dysplasia (HP:0007033)	2.73136270
15	Hypothermia (HP:0002045)	2.71538243
16	Bilateral microphthalmos (HP:0007633)	2.68541400
17	Congenital stationary night blindness (HP:0007642)	2.65590944
18	Gait imbalance (HP:0002141)	2.56855979
19	Congenital primary aphakia (HP:0007707)	2.54949671
20	Chronic hepatic failure (HP:0100626)	2.53168126
21	Attenuation of retinal blood vessels (HP:0007843)	2.53022245
22	Hyperglycinuria (HP:0003108)	2.48648001
23	Sclerocornea (HP:0000647)	2.48355699
24	Genetic anticipation (HP:0003743)	2.45759763
25	Hyperglycinemia (HP:0002154)	2.44401840
26	Genital tract atresia (HP:0001827)	2.40082179
27	Anencephaly (HP:0002323)	2.36615825
28	Vaginal atresia (HP:0000148)	2.35405367
29	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.34679680
30	Nephrogenic diabetes insipidus (HP:0009806)	2.32721580
31	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.31216913
32	Intestinal atresia (HP:0011100)	2.29663623
33	Decreased circulating renin level (HP:0003351)	2.28702421
34	Progressive cerebellar ataxia (HP:0002073)	2.26093373
35	Lissencephaly (HP:0001339)	2.24343242
36	Abnormal drinking behavior (HP:0030082)	2.23191780
37	Polydipsia (HP:0001959)	2.23191780
38	Anophthalmia (HP:0000528)	2.23099768
39	Gaze-evoked nystagmus (HP:0000640)	2.21826029
40	Renal cortical cysts (HP:0000803)	2.19620729
41	Midline defect of the nose (HP:0004122)	2.16476714
42	Preaxial foot polydactyly (HP:0001841)	2.15171062
43	Poor coordination (HP:0002370)	2.14118574
44	Postaxial foot polydactyly (HP:0001830)	2.14106568
45	Small hand (HP:0200055)	2.13129821
46	Colon cancer (HP:0003003)	2.11741379
47	Congenital hepatic fibrosis (HP:0002612)	2.09282561
48	Large for gestational age (HP:0001520)	2.08520389
49	Male pseudohermaphroditism (HP:0000037)	2.03930901
50	Broad-based gait (HP:0002136)	2.03751332
51	Bifid tongue (HP:0010297)	2.03745435
52	Abnormal biliary tract physiology (HP:0012439)	2.02733001
53	Bile duct proliferation (HP:0001408)	2.02733001
54	Abnormality of the labia minora (HP:0012880)	2.02028522
55	Hypoplasia of the pons (HP:0012110)	2.01027851
56	Congenital, generalized hypertrichosis (HP:0004540)	1.99497202
57	Preaxial hand polydactyly (HP:0001177)	1.98819944
58	Postaxial hand polydactyly (HP:0001162)	1.96411228
59	Tented upper lip vermilion (HP:0010804)	1.96409135
60	Optic nerve hypoplasia (HP:0000609)	1.95975913
61	Abolished electroretinogram (ERG) (HP:0000550)	1.95238058
62	Abnormality of serine family amino acid metabolism (HP:0010894)	1.95074506
63	Abnormality of glycine metabolism (HP:0010895)	1.95074506
64	Tubulointerstitial abnormality (HP:0001969)	1.92061633
65	Tubulointerstitial nephritis (HP:0001970)	1.91959737
66	Furrowed tongue (HP:0000221)	1.89913164
67	Hypoplastic labia majora (HP:0000059)	1.87655165
68	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.86214479
69	Protruding tongue (HP:0010808)	1.85643767
70	Abnormality of the pons (HP:0007361)	1.83775833
71	Febrile seizures (HP:0002373)	1.83773906
72	Exotropia (HP:0000577)	1.80459366
73	Pendular nystagmus (HP:0012043)	1.79732122
74	Bony spicule pigmentary retinopathy (HP:0007737)	1.79322781
75	Proximal tubulopathy (HP:0000114)	1.77536081
76	Absent speech (HP:0001344)	1.77443324
77	Fair hair (HP:0002286)	1.76031169
78	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.75630093
79	Absent/shortened dynein arms (HP:0200106)	1.75630093
80	Hypoplastic ischia (HP:0003175)	1.72083106
81	Abnormality of the labia majora (HP:0012881)	1.70990914
82	Abnormal rod and cone electroretinograms (HP:0008323)	1.70987499
83	Polyuria (HP:0000103)	1.70565197
84	Enlarged kidneys (HP:0000105)	1.69738610
85	Type I transferrin isoform profile (HP:0003642)	1.67231706
86	Abnormal ciliary motility (HP:0012262)	1.66466829
87	Highly arched eyebrow (HP:0002553)	1.66311796
88	Tachypnea (HP:0002789)	1.65101611
89	Dandy-Walker malformation (HP:0001305)	1.63715025
90	Hypoplasia of the ulna (HP:0003022)	1.63531434
91	Multicystic kidney dysplasia (HP:0000003)	1.63438365
92	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.63176663
93	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.63007716
94	Tubulointerstitial fibrosis (HP:0005576)	1.62477137
95	Prominent nasal bridge (HP:0000426)	1.60454690
96	Anal stenosis (HP:0002025)	1.60270047
97	Amelogenesis imperfecta (HP:0000705)	1.60148504
98	Volvulus (HP:0002580)	1.59277068
99	Abnormality of the vitreous humor (HP:0004327)	1.57862621
100	Absent eyebrow (HP:0002223)	1.57481254

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.55583817
2	AKT3	3.81799122
3	MAP4K2	2.86839896
4	CASK	2.86789999
5	WNK4	2.58052811
6	WNK3	2.54312726
7	BMPR1B	2.24356098
8	ACVR1B	2.15922646
9	TRIM28	2.12537436
10	PNCK	1.98744222
11	STK39	1.86996641
12	NUAK1	1.80541386
13	STK38L	1.79874059
14	ADRBK2	1.79492371
15	PINK1	1.72386779
16	TAOK3	1.71869927
17	MKNK2	1.67216400
18	LATS1	1.66644097
19	GRK1	1.60916493
20	NTRK3	1.57614426
21	BRSK2	1.56682233
22	MARK1	1.56326733
23	INSRR	1.51281174
24	MAP3K4	1.47132561
25	ZAK	1.43771074
26	TAF1	1.42934468
27	MAPK13	1.30559618
28	BCR	1.29631257
29	SGK2	1.27424410
30	STK3	1.21801755
31	EPHA4	1.15551014
32	NME1	1.14715713
33	MKNK1	1.14328114
34	CAMK1G	1.13747332
35	EPHB2	1.10978011
36	WEE1	1.07655136
37	OXSR1	1.06530228
38	PAK3	1.06305503
39	PLK4	1.02864153
40	DAPK2	1.00760529
41	FGFR2	0.98414837
42	TGFBR1	0.95958068
43	PRKCG	0.90382320
44	BRD4	0.86309921
45	TNIK	0.83730863
46	CAMK1D	0.81635317
47	SGK494	0.80055419
48	SGK223	0.80055419
49	PRKCE	0.79949971
50	PTK2B	0.74446702
51	TLK1	0.72103053
52	STK16	0.68186856
53	ERBB2	0.68135643
54	PIK3CG	0.65549149
55	ADRBK1	0.64546577
56	EIF2AK3	0.64388918
57	OBSCN	0.62283691
58	TNK2	0.61480335
59	PASK	0.60711224
60	VRK1	0.60598851
61	PIK3CA	0.59690367
62	CSNK1A1L	0.58042985
63	CSNK1G1	0.56787983
64	PRKAA1	0.56582377
65	NEK2	0.55945544
66	ERBB3	0.55580666
67	FGFR1	0.53415102
68	DYRK2	0.52800581
69	CDK3	0.52512228
70	EIF2AK2	0.51880020
71	PRKAA2	0.51425407
72	PLK3	0.49222478
73	CAMK1	0.48804338
74	MAPKAPK3	0.47601346
75	ATM	0.47253650
76	NTRK2	0.46974849
77	CSNK1E	0.46188493
78	CDC7	0.45597332
79	CSNK1A1	0.45553915
80	DYRK3	0.45003657
81	PRKACA	0.44881573
82	STK11	0.44857190
83	WNK1	0.44254109
84	BRSK1	0.43251417
85	PLK2	0.42848565
86	KSR1	0.42812446
87	EIF2AK1	0.42641629
88	STK38	0.42299302
89	CSNK1G2	0.41644273
90	MAP3K7	0.40116261
91	CAMK2A	0.39704823
92	CHEK2	0.39691006
93	CSNK1D	0.39581919
94	SGK3	0.39545811
95	PRKACB	0.38285929
96	ATR	0.36808394
97	MAPKAPK5	0.32960818
98	FER	0.32335594
99	SGK1	0.31835624
100	FLT3	0.31791491

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.79270339
2	Butanoate metabolism_Homo sapiens_hsa00650	2.74449437
3	Phototransduction_Homo sapiens_hsa04744	2.38871812
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.31681634
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.22798113
6	One carbon pool by folate_Homo sapiens_hsa00670	2.16427214
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.11906019
8	Tryptophan metabolism_Homo sapiens_hsa00380	2.04836656
9	Nicotine addiction_Homo sapiens_hsa05033	2.03537298
10	ABC transporters_Homo sapiens_hsa02010	1.99912100
11	Nitrogen metabolism_Homo sapiens_hsa00910	1.96925156
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.89973958
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.88746854
14	Homologous recombination_Homo sapiens_hsa03440	1.86950481
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.81362350
16	Basal transcription factors_Homo sapiens_hsa03022	1.76721444
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.76342197
18	Propanoate metabolism_Homo sapiens_hsa00640	1.73266227
19	Taste transduction_Homo sapiens_hsa04742	1.69438411
20	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.67602650
21	Protein export_Homo sapiens_hsa03060	1.65381180
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.65161788
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.54265736
24	Oxidative phosphorylation_Homo sapiens_hsa00190	1.53023621
25	Olfactory transduction_Homo sapiens_hsa04740	1.50143945
26	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.49746802
27	beta-Alanine metabolism_Homo sapiens_hsa00410	1.45038553
28	Histidine metabolism_Homo sapiens_hsa00340	1.43270263
29	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.36201772
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.36055632
31	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.32259289
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.29798592
33	Retinol metabolism_Homo sapiens_hsa00830	1.21830255
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.21374597
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.20141378
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.17370153
37	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.16512414
38	Morphine addiction_Homo sapiens_hsa05032	1.12365704
39	Serotonergic synapse_Homo sapiens_hsa04726	1.08928088
40	Huntingtons disease_Homo sapiens_hsa05016	1.08643650
41	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.07710202
42	Ribosome_Homo sapiens_hsa03010	1.06405509
43	Parkinsons disease_Homo sapiens_hsa05012	1.05184949
44	Basal cell carcinoma_Homo sapiens_hsa05217	1.04082774
45	Glutamatergic synapse_Homo sapiens_hsa04724	1.03180658
46	RNA polymerase_Homo sapiens_hsa03020	0.98145659
47	RNA degradation_Homo sapiens_hsa03018	0.97904564
48	Circadian entrainment_Homo sapiens_hsa04713	0.97900405
49	GABAergic synapse_Homo sapiens_hsa04727	0.97501945
50	Caffeine metabolism_Homo sapiens_hsa00232	0.97387903
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.97307570
52	Non-homologous end-joining_Homo sapiens_hsa03450	0.92902060
53	Peroxisome_Homo sapiens_hsa04146	0.91969057
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.91053661
55	Insulin secretion_Homo sapiens_hsa04911	0.89705781
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.89369591
57	Lysine degradation_Homo sapiens_hsa00310	0.88928168
58	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.88736486
59	Mineral absorption_Homo sapiens_hsa04978	0.87618020
60	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.85509777
61	Circadian rhythm_Homo sapiens_hsa04710	0.85022693
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.83021879
63	Steroid biosynthesis_Homo sapiens_hsa00100	0.81903550
64	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.75172008
65	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.74108044
66	Fatty acid metabolism_Homo sapiens_hsa01212	0.74073291
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.72861605
68	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.72301110
69	Cardiac muscle contraction_Homo sapiens_hsa04260	0.71917370
70	Sulfur relay system_Homo sapiens_hsa04122	0.71916696
71	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.70829982
72	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.68726022
73	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.68512499
74	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.67480001
75	Alzheimers disease_Homo sapiens_hsa05010	0.67115380
76	Bile secretion_Homo sapiens_hsa04976	0.66238747
77	Fatty acid degradation_Homo sapiens_hsa00071	0.64978046
78	Metabolic pathways_Homo sapiens_hsa01100	0.63369123
79	Purine metabolism_Homo sapiens_hsa00230	0.62641698
80	Dopaminergic synapse_Homo sapiens_hsa04728	0.59872964
81	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.59050849
82	Cocaine addiction_Homo sapiens_hsa05030	0.58196538
83	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.57650765
84	Arginine and proline metabolism_Homo sapiens_hsa00330	0.56622796
85	Calcium signaling pathway_Homo sapiens_hsa04020	0.55952819
86	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.53441338
87	RNA transport_Homo sapiens_hsa03013	0.51513731
88	Regulation of autophagy_Homo sapiens_hsa04140	0.51289733
89	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.50620708
90	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.49294629
91	Salivary secretion_Homo sapiens_hsa04970	0.48816253
92	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.48414772
93	Hippo signaling pathway_Homo sapiens_hsa04390	0.47987140
94	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42678808
95	Amphetamine addiction_Homo sapiens_hsa05031	0.41528247
96	cAMP signaling pathway_Homo sapiens_hsa04024	0.41420443
97	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.41115227
98	Tyrosine metabolism_Homo sapiens_hsa00350	0.38992755
99	Nucleotide excision repair_Homo sapiens_hsa03420	0.38306596
100	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.38014190

FAR2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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