ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	presynaptic membrane assembly (GO:0097105)	3.53823738
2	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.47646296
3	cellular ketone body metabolic process (GO:0046950)	3.26979225
4	presynaptic membrane organization (GO:0097090)	3.25813219
5	adaptation of signaling pathway (GO:0023058)	3.20639754
6	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.17665795
7	atrial cardiac muscle cell action potential (GO:0086014)	3.16791123
8	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.10898256
9	neuron cell-cell adhesion (GO:0007158)	3.09583842
10	righting reflex (GO:0060013)	3.06343652
11	reflex (GO:0060004)	2.97461091
12	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.97010902
13	dendritic spine morphogenesis (GO:0060997)	2.95690532
14	insulin secretion (GO:0030073)	2.93997540
15	glycerophospholipid catabolic process (GO:0046475)	2.90803798
16	endocrine pancreas development (GO:0031018)	2.90468950
17	ketone body metabolic process (GO:1902224)	2.89075295
18	positive regulation of glycolytic process (GO:0045821)	2.88604472
19	signal peptide processing (GO:0006465)	2.87721638
20	negative regulation of hormone biosynthetic process (GO:0032353)	2.81575891
21	pyrimidine nucleobase catabolic process (GO:0006208)	2.79168637
22	nodal signaling pathway (GO:0038092)	2.78457047
23	nucleobase catabolic process (GO:0046113)	2.77482460
24	regulation of glucokinase activity (GO:0033131)	2.75849905
25	regulation of hexokinase activity (GO:1903299)	2.75849905
26	retinal ganglion cell axon guidance (GO:0031290)	2.75458977
27	nephron tubule morphogenesis (GO:0072078)	2.71940460
28	nephron epithelium morphogenesis (GO:0072088)	2.71940460
29	respiratory chain complex IV assembly (GO:0008535)	2.71791589
30	hindbrain development (GO:0030902)	2.62281425
31	protein localization to cilium (GO:0061512)	2.59611859
32	cytochrome complex assembly (GO:0017004)	2.59476106
33	behavioral response to nicotine (GO:0035095)	2.57289083
34	glutamate receptor signaling pathway (GO:0007215)	2.55678218
35	detection of temperature stimulus (GO:0016048)	2.55431364
36	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.54513602
37	axoneme assembly (GO:0035082)	2.53660381
38	neuron fate specification (GO:0048665)	2.53627582
39	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.50963023
40	spinal cord motor neuron differentiation (GO:0021522)	2.50323949
41	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.50094485
42	neurofilament cytoskeleton organization (GO:0060052)	2.49182359
43	renal tubule morphogenesis (GO:0061333)	2.48122138
44	innervation (GO:0060384)	2.47646759
45	gamma-aminobutyric acid transport (GO:0015812)	2.47136043
46	nonmotile primary cilium assembly (GO:0035058)	2.47018348
47	regulation of neurotransmitter uptake (GO:0051580)	2.46286992
48	kidney morphogenesis (GO:0060993)	2.46077734
49	positive regulation of meiosis (GO:0045836)	2.46013154
50	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.44901091
51	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.44901091
52	regulation of translation, ncRNA-mediated (GO:0045974)	2.44901091
53	epithelial cell fate commitment (GO:0072148)	2.42072389
54	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.41621266
55	retinol metabolic process (GO:0042572)	2.41302659
56	regulation of respiratory system process (GO:0044065)	2.40148996
57	positive regulation of insulin secretion (GO:0032024)	2.39902102
58	establishment of protein localization to Golgi (GO:0072600)	2.39820879
59	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.39396475
60	inositol phosphate catabolic process (GO:0071545)	2.38705285
61	retinal metabolic process (GO:0042574)	2.36836195
62	positive regulation of neurotransmitter transport (GO:0051590)	2.35419008
63	proline transport (GO:0015824)	2.34472641
64	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.32886607
65	cochlea development (GO:0090102)	2.32352757
66	serotonin metabolic process (GO:0042428)	2.32185768
67	protein localization to synapse (GO:0035418)	2.31617238
68	positive regulation of histone H3-K4 methylation (GO:0051571)	2.31499979
69	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	2.30836128
70	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.29470488
71	epithelial cilium movement (GO:0003351)	2.28401359
72	membrane depolarization during action potential (GO:0086010)	2.28387210
73	synapsis (GO:0007129)	2.27987442
74	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.27572438
75	axonal fasciculation (GO:0007413)	2.26799019
76	positive regulation of meiotic cell cycle (GO:0051446)	2.26315909
77	artery development (GO:0060840)	2.26031689
78	protein complex biogenesis (GO:0070271)	2.25883421
79	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.25119971
80	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.25119971
81	negative regulation of hormone metabolic process (GO:0032351)	2.24708446
82	type B pancreatic cell development (GO:0003323)	2.23118244
83	somite rostral/caudal axis specification (GO:0032525)	2.21164713
84	brain morphogenesis (GO:0048854)	2.20824032
85	vocalization behavior (GO:0071625)	2.20628335
86	glandular epithelial cell differentiation (GO:0002067)	2.20376979
87	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.20360445
88	retinal cone cell development (GO:0046549)	2.20258634
89	polyol catabolic process (GO:0046174)	2.20034951
90	positive regulation of gluconeogenesis (GO:0045722)	2.19515053
91	synaptic transmission, glutamatergic (GO:0035249)	2.19509014
92	postsynaptic membrane organization (GO:0001941)	2.19036385
93	cranial nerve development (GO:0021545)	2.18940374
94	protein targeting to Golgi (GO:0000042)	2.18848884
95	alanine transport (GO:0032328)	2.17831299
96	iron ion import (GO:0097286)	2.17786233
97	startle response (GO:0001964)	2.17425604
98	magnesium ion transport (GO:0015693)	2.16719810
99	regulation of membrane repolarization (GO:0060306)	2.16145880
100	pancreas development (GO:0031016)	2.15439125

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.06998854
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.06828826
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.66166469
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.64368065
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.62875319
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.59212558
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.55729052
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.55532653
9	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.54561211
10	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.48568754
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.40494971
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.35317438
13	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.26986940
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.26593336
15	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.23967826
16	VDR_22108803_ChIP-Seq_LS180_Human	2.23631765
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.23605482
18	FUS_26573619_Chip-Seq_HEK293_Human	2.20227122
19	P300_19829295_ChIP-Seq_ESCs_Human	2.12537251
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.04289649
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.00339449
22	EWS_26573619_Chip-Seq_HEK293_Human	1.97034156
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.95114993
24	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.92365436
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.88602713
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.83686540
27	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.71201519
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.69066610
29	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.68399990
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.66747560
31	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.64472323
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.64178277
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.63729894
34	REST_21632747_ChIP-Seq_MESCs_Mouse	1.63344925
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.63242745
36	AR_21572438_ChIP-Seq_LNCaP_Human	1.62132433
37	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.59659477
38	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.58285540
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.58285540
40	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.56935151
41	STAT3_23295773_ChIP-Seq_U87_Human	1.54707370
42	AR_25329375_ChIP-Seq_VCAP_Human	1.52784043
43	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.50260509
44	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.48765110
45	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.46342319
46	TCF4_23295773_ChIP-Seq_U87_Human	1.45156922
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.43339621
48	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.42585578
49	RNF2_27304074_Chip-Seq_NSC_Mouse	1.42082094
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41784374
51	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.40109738
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38318298
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35420662
54	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.32310526
55	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.32190653
56	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.28875242
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.28791514
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.28791514
59	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.27496066
60	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27203224
61	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.26644055
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.26487145
63	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.24288311
64	P53_22387025_ChIP-Seq_ESCs_Mouse	1.22397291
65	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.21943086
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.21576037
67	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.20993337
68	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.20400629
69	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.19816691
70	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.19605235
71	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18201871
72	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.16418991
73	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16055620
74	TCF4_22108803_ChIP-Seq_LS180_Human	1.13932236
75	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.13688204
76	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.13329009
77	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.12180222
78	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.10561590
79	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.08728132
80	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.08658644
81	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.07508838
82	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.07186604
83	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.06529957
84	TP53_22573176_ChIP-Seq_HFKS_Human	1.06198631
85	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.05565148
86	HTT_18923047_ChIP-ChIP_STHdh_Human	1.05360784
87	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.05006415
88	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.04427807
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.04217698
90	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.04154252
91	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.04132724
92	P300_18555785_Chip-Seq_ESCs_Mouse	1.03274267
93	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.03238942
94	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03077838
95	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02283041
96	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.02207139
97	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.01812381
98	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01525608
99	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.01194813
100	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.01157810

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	2.53106454
2	MP0002735_abnormal_chemical_nociception	2.48899108
3	MP0002909_abnormal_adrenal_gland	2.31670200
4	MP0002837_dystrophic_cardiac_calcinosis	2.27944534
5	MP0001968_abnormal_touch/_nociception	2.26953782
6	MP0008877_abnormal_DNA_methylation	2.23193936
7	MP0005646_abnormal_pituitary_gland	2.19519692
8	MP0003011_delayed_dark_adaptation	2.16834393
9	MP0006072_abnormal_retinal_apoptosis	2.12394698
10	MP0002822_catalepsy	2.10442298
11	MP0003787_abnormal_imprinting	2.06997601
12	MP0003122_maternal_imprinting	2.01115076
13	MP0009046_muscle_twitch	2.01040327
14	MP0004043_abnormal_pH_regulation	2.00177685
15	MP0003890_abnormal_embryonic-extraembry	2.00053947
16	MP0004270_analgesia	1.96226429
17	MP0005551_abnormal_eye_electrophysiolog	1.89279619
18	MP0000631_abnormal_neuroendocrine_gland	1.82236545
19	MP0000569_abnormal_digit_pigmentation	1.78783074
20	MP0009745_abnormal_behavioral_response	1.73424011
21	MP0005645_abnormal_hypothalamus_physiol	1.69885644
22	MP0003195_calcinosis	1.69604984
23	MP0004133_heterotaxia	1.68308417
24	MP0002733_abnormal_thermal_nociception	1.63857142
25	MP0002938_white_spotting	1.63246604
26	MP0003880_abnormal_central_pattern	1.63193509
27	MP0002272_abnormal_nervous_system	1.59110997
28	MP0001944_abnormal_pancreas_morphology	1.58594709
29	MP0004885_abnormal_endolymph	1.58067174
30	MP0002638_abnormal_pupillary_reflex	1.57764817
31	MP0002557_abnormal_social/conspecific_i	1.55795396
32	MP0001486_abnormal_startle_reflex	1.55700524
33	MP0003121_genomic_imprinting	1.54612428
34	MP0005253_abnormal_eye_physiology	1.53124438
35	MP0002572_abnormal_emotion/affect_behav	1.51406211
36	MP0005379_endocrine/exocrine_gland_phen	1.50210194
37	MP0002064_seizures	1.49930931
38	MP0001984_abnormal_olfaction	1.49668437
39	MP0003635_abnormal_synaptic_transmissio	1.49046138
40	MP0001970_abnormal_pain_threshold	1.48043141
41	MP0009780_abnormal_chondrocyte_physiolo	1.45859209
42	MP0000566_synostosis	1.45609779
43	MP0003283_abnormal_digestive_organ	1.42653146
44	MP0002234_abnormal_pharynx_morphology	1.40879999
45	MP0004859_abnormal_synaptic_plasticity	1.40852597
46	MP0002063_abnormal_learning/memory/cond	1.39829465
47	MP0005167_abnormal_blood-brain_barrier	1.35706850
48	MP0004924_abnormal_behavior	1.34526675
49	MP0005386_behavior/neurological_phenoty	1.34526675
50	MP0003136_yellow_coat_color	1.32436826
51	MP0002693_abnormal_pancreas_physiology	1.32034952
52	MP0008057_abnormal_DNA_replication	1.30357912
53	MP0005423_abnormal_somatic_nervous	1.28997944
54	MP0010386_abnormal_urinary_bladder	1.28248686
55	MP0002734_abnormal_mechanical_nocicepti	1.26733749
56	MP0001188_hyperpigmentation	1.26727910
57	MP0000778_abnormal_nervous_system	1.21915061
58	MP0002067_abnormal_sensory_capabilities	1.20767384
59	MP0001529_abnormal_vocalization	1.20737554
60	MP0003633_abnormal_nervous_system	1.20393975
61	MP0001501_abnormal_sleep_pattern	1.20179374
62	MP0002876_abnormal_thyroid_physiology	1.19625862
63	MP0001485_abnormal_pinna_reflex	1.18705231
64	MP0002102_abnormal_ear_morphology	1.18560429
65	MP0005084_abnormal_gallbladder_morpholo	1.16536267
66	MP0002163_abnormal_gland_morphology	1.13434285
67	MP0006292_abnormal_olfactory_placode	1.11109906
68	MP0002184_abnormal_innervation	1.10632044
69	MP0004742_abnormal_vestibular_system	1.10569855
70	MP0005187_abnormal_penis_morphology	1.06798904
71	MP0004019_abnormal_vitamin_homeostasis	1.06314720
72	MP0005220_abnormal_exocrine_pancreas	1.04453491
73	MP0008995_early_reproductive_senescence	1.02393150
74	MP0006276_abnormal_autonomic_nervous	1.02277055
75	MP0002090_abnormal_vision	1.00454994
76	MP0003938_abnormal_ear_development	0.99055177
77	MP0005367_renal/urinary_system_phenotyp	0.98956575
78	MP0000516_abnormal_urinary_system	0.98956575
79	MP0003718_maternal_effect	0.98874103
80	MP0000955_abnormal_spinal_cord	0.96100860
81	MP0004085_abnormal_heartbeat	0.95335059
82	MP0002078_abnormal_glucose_homeostasis	0.94861944
83	MP0001502_abnormal_circadian_rhythm	0.94135110
84	MP0001756_abnormal_urination	0.93964460
85	MP0005636_abnormal_mineral_homeostasis	0.92037416
86	MP0003937_abnormal_limbs/digits/tail_de	0.89325260
87	MP0010329_abnormal_lipoprotein_level	0.88044871
88	MP0003123_paternal_imprinting	0.87184911
89	MP0003953_abnormal_hormone_level	0.87128293
90	MP0005248_abnormal_Harderian_gland	0.86461320
91	MP0002882_abnormal_neuron_morphology	0.85559256
92	MP0003631_nervous_system_phenotype	0.81574300
93	MP0004811_abnormal_neuron_physiology	0.81278148
94	MP0002928_abnormal_bile_duct	0.80673139
95	MP0005448_abnormal_energy_balance	0.80538667
96	MP0004215_abnormal_myocardial_fiber	0.80352907
97	MP0001299_abnormal_eye_distance/	0.79804780
98	MP0002229_neurodegeneration	0.79096946
99	MP0002751_abnormal_autonomic_nervous	0.77115724
100	MP0003698_abnormal_male_reproductive	0.76727519

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Intestinal atresia (HP:0011100)	4.01644444
2	Gaze-evoked nystagmus (HP:0000640)	3.34334202
3	Hypothermia (HP:0002045)	3.23430087
4	Pancreatic cysts (HP:0001737)	3.13792549
5	Progressive cerebellar ataxia (HP:0002073)	3.11334286
6	Pancreatic fibrosis (HP:0100732)	2.94676214
7	Decreased circulating renin level (HP:0003351)	2.73436181
8	Abnormality of the labia minora (HP:0012880)	2.71770154
9	True hermaphroditism (HP:0010459)	2.70825676
10	Nephronophthisis (HP:0000090)	2.70822650
11	Medial flaring of the eyebrow (HP:0010747)	2.68963165
12	Broad-based gait (HP:0002136)	2.56957648
13	Abnormality of midbrain morphology (HP:0002418)	2.48414354
14	Molar tooth sign on MRI (HP:0002419)	2.48414354
15	Ketoacidosis (HP:0001993)	2.48017443
16	Gait imbalance (HP:0002141)	2.43155885
17	Hyperventilation (HP:0002883)	2.42621606
18	Gastrointestinal atresia (HP:0002589)	2.39728680
19	Limb dystonia (HP:0002451)	2.38754507
20	Abnormality of the renal medulla (HP:0100957)	2.37236313
21	Febrile seizures (HP:0002373)	2.36966852
22	Congenital stationary night blindness (HP:0007642)	2.36555346
23	Abnormality of the renal cortex (HP:0011035)	2.34208723
24	Focal motor seizures (HP:0011153)	2.33147877
25	EEG with generalized epileptiform discharges (HP:0011198)	2.28732646
26	Hemiparesis (HP:0001269)	2.28152653
27	Epileptiform EEG discharges (HP:0011182)	2.27925004
28	Genetic anticipation (HP:0003743)	2.25201448
29	Double outlet right ventricle (HP:0001719)	2.22853148
30	Congenital malformation of the right heart (HP:0011723)	2.22853148
31	Hypsarrhythmia (HP:0002521)	2.21973578
32	Volvulus (HP:0002580)	2.21469396
33	Congenital primary aphakia (HP:0007707)	2.21264158
34	Large for gestational age (HP:0001520)	2.21251437
35	Dialeptic seizures (HP:0011146)	2.17706417
36	Hypoglycemic coma (HP:0001325)	2.16108437
37	Genital tract atresia (HP:0001827)	2.14678966
38	Optic nerve hypoplasia (HP:0000609)	2.12580185
39	Abnormality of vitamin B metabolism (HP:0004340)	2.09764165
40	Absence seizures (HP:0002121)	2.08513977
41	Nephrogenic diabetes insipidus (HP:0009806)	2.06507065
42	Abdominal situs inversus (HP:0003363)	2.05180804
43	Abnormality of abdominal situs (HP:0011620)	2.05180804
44	Focal seizures (HP:0007359)	2.04917812
45	Aqueductal stenosis (HP:0002410)	2.03896678
46	Methylmalonic acidemia (HP:0002912)	2.03716558
47	Attenuation of retinal blood vessels (HP:0007843)	2.02320748
48	Hypoglycemic seizures (HP:0002173)	2.01929721
49	Renal cortical cysts (HP:0000803)	2.01463688
50	Cystic liver disease (HP:0006706)	1.98765942
51	Vaginal atresia (HP:0000148)	1.98131349
52	Bony spicule pigmentary retinopathy (HP:0007737)	1.97574291
53	Hyperinsulinemic hypoglycemia (HP:0000825)	1.97296268
54	Agitation (HP:0000713)	1.93600574
55	Sclerocornea (HP:0000647)	1.92288923
56	Pheochromocytoma (HP:0002666)	1.91698838
57	Increased circulating renin level (HP:0000848)	1.90163814
58	Hyperglycinuria (HP:0003108)	1.88606167
59	Atonic seizures (HP:0010819)	1.88556378
60	Type II lissencephaly (HP:0007260)	1.86261339
61	Abnormality of renin-angiotensin system (HP:0000847)	1.86237542
62	Polyphagia (HP:0002591)	1.85778005
63	Protruding tongue (HP:0010808)	1.85024904
64	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.82728920
65	Ketosis (HP:0001946)	1.79678880
66	Male pseudohermaphroditism (HP:0000037)	1.79477304
67	Furrowed tongue (HP:0000221)	1.79009751
68	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.77772715
69	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.77772715
70	Sleep apnea (HP:0010535)	1.77235471
71	Progressive macrocephaly (HP:0004481)	1.77127879
72	Colon cancer (HP:0003003)	1.77059598
73	Oligodactyly (hands) (HP:0001180)	1.74550963
74	Neoplasm of the oral cavity (HP:0100649)	1.73774155
75	Epileptic encephalopathy (HP:0200134)	1.72986090
76	Prolonged QT interval (HP:0001657)	1.72721990
77	Widely spaced teeth (HP:0000687)	1.72611601
78	Lissencephaly (HP:0001339)	1.71606604
79	Labial hypoplasia (HP:0000066)	1.69834639
80	Drooling (HP:0002307)	1.69047365
81	Poor coordination (HP:0002370)	1.68682907
82	Fair hair (HP:0002286)	1.68254383
83	Myokymia (HP:0002411)	1.68097040
84	Enlarged penis (HP:0000040)	1.67583706
85	Tubulointerstitial nephritis (HP:0001970)	1.66549755
86	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.66412634
87	Hypomagnesemia (HP:0002917)	1.63522621
88	Septate vagina (HP:0001153)	1.62568126
89	Hepatoblastoma (HP:0002884)	1.62306126
90	Abnormality of the nasal septum (HP:0000419)	1.62211533
91	Septo-optic dysplasia (HP:0100842)	1.62134138
92	Generalized hypopigmentation of hair (HP:0011358)	1.61974872
93	Neuroendocrine neoplasm (HP:0100634)	1.61689497
94	Abnormality of vitamin metabolism (HP:0100508)	1.61588996
95	Hypoplasia of the pons (HP:0012110)	1.60584783
96	Abnormal drinking behavior (HP:0030082)	1.60465885
97	Polydipsia (HP:0001959)	1.60465885
98	Hyperaldosteronism (HP:0000859)	1.60352101
99	Growth hormone deficiency (HP:0000824)	1.59374356
100	Abolished electroretinogram (ERG) (HP:0000550)	1.59301876

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.98805488
2	CASK	3.31491523
3	AKT3	3.00238105
4	WNK3	2.63744073
5	PNCK	2.58611478
6	MAP3K4	2.51942140
7	NTRK3	2.43722005
8	DAPK2	2.39343249
9	TNIK	2.36506419
10	MKNK2	2.34088951
11	MARK1	2.32103375
12	MAP4K2	2.29198478
13	BMPR1B	2.26363962
14	FGFR2	1.91224356
15	SGK2	1.78373800
16	GRK1	1.73148591
17	STK38L	1.63925902
18	ACVR1B	1.60629319
19	MAPK13	1.59387511
20	CAMK1G	1.59383289
21	MAP2K6	1.47084337
22	MAP3K12	1.42780866
23	SGK223	1.42268209
24	SGK494	1.42268209
25	PAK3	1.34341672
26	PINK1	1.33863179
27	PHKG2	1.32874977
28	PHKG1	1.32874977
29	NLK	1.31450727
30	INSRR	1.27593103
31	ADRBK2	1.26557532
32	OXSR1	1.22103518
33	CAMK1D	1.19025270
34	PLK2	1.17293993
35	MKNK1	1.16663468
36	WNK4	1.15520926
37	STK3	1.12813441
38	PRKCG	1.08088048
39	LATS1	1.06690952
40	STK39	1.03370909
41	TNK2	1.02250720
42	PRKCE	1.01368022
43	DYRK2	0.99834838
44	MST4	0.96391323
45	ERBB3	0.96041757
46	EPHA4	0.95901361
47	MAP2K7	0.94139466
48	NUAK1	0.92628850
49	FGFR3	0.92021205
50	TAOK3	0.88125838
51	MAP2K4	0.86761051
52	NTRK2	0.86454305
53	SGK3	0.81443188
54	ZAK	0.80767458
55	PASK	0.79951543
56	EPHA3	0.78062033
57	STK11	0.77265163
58	SGK1	0.76847075
59	UHMK1	0.74131765
60	NME1	0.66081845
61	PLK3	0.65867645
62	CSNK1G1	0.63511083
63	MINK1	0.60781540
64	CDK3	0.60581272
65	TGFBR1	0.57984010
66	CAMK2A	0.55943659
67	FGFR1	0.55750792
68	YES1	0.54426090
69	CSNK1G2	0.54400180
70	DYRK3	0.53978040
71	PRKAA1	0.53959772
72	DYRK1A	0.53061790
73	CSNK1E	0.52762030
74	STK38	0.50576905
75	CDK5	0.48569988
76	PRKACA	0.48163605
77	PRKG1	0.48118508
78	CSNK1A1	0.47527882
79	CAMK1	0.45509613
80	ATM	0.45005250
81	FER	0.43824383
82	PRKACB	0.43152382
83	BRSK2	0.42911266
84	VRK1	0.42365868
85	PRKCZ	0.40457154
86	STK16	0.39846040
87	CSNK1D	0.39409080
88	WEE1	0.38365633
89	CAMK2D	0.37371269
90	ERBB2	0.36786692
91	TEC	0.36327085
92	CSNK1A1L	0.35614424
93	RPS6KA3	0.35588097
94	ADRBK1	0.35557437
95	PRKAA2	0.35270154
96	OBSCN	0.34245692
97	TAF1	0.34053031
98	GSK3B	0.33397533
99	PLK4	0.32485289
100	TAOK1	0.32181460

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.87227158
2	Butanoate metabolism_Homo sapiens_hsa00650	2.65373092
3	Nicotine addiction_Homo sapiens_hsa05033	2.63728017
4	Protein export_Homo sapiens_hsa03060	2.56540587
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.40642081
6	Insulin secretion_Homo sapiens_hsa04911	2.18377996
7	Oxidative phosphorylation_Homo sapiens_hsa00190	1.96434259
8	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.89619285
9	Phototransduction_Homo sapiens_hsa04744	1.84875495
10	Taste transduction_Homo sapiens_hsa04742	1.82928125
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.67261408
12	GABAergic synapse_Homo sapiens_hsa04727	1.52183566
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.48816972
14	Propanoate metabolism_Homo sapiens_hsa00640	1.48412702
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.48356206
16	Circadian entrainment_Homo sapiens_hsa04713	1.47902885
17	Circadian rhythm_Homo sapiens_hsa04710	1.47830714
18	Glutamatergic synapse_Homo sapiens_hsa04724	1.44681076
19	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.40342859
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.39130763
21	Amphetamine addiction_Homo sapiens_hsa05031	1.38813346
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.37869918
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.35357399
24	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.32796000
25	Morphine addiction_Homo sapiens_hsa05032	1.31531187
26	Olfactory transduction_Homo sapiens_hsa04740	1.31400054
27	Serotonergic synapse_Homo sapiens_hsa04726	1.31301371
28	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.30093497
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.28852651
30	Parkinsons disease_Homo sapiens_hsa05012	1.25973800
31	Dopaminergic synapse_Homo sapiens_hsa04728	1.24002649
32	beta-Alanine metabolism_Homo sapiens_hsa00410	1.20154993
33	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.20064653
34	Cardiac muscle contraction_Homo sapiens_hsa04260	1.18755531
35	ABC transporters_Homo sapiens_hsa02010	1.18721724
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.17401111
37	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.13368698
38	Collecting duct acid secretion_Homo sapiens_hsa04966	1.13258806
39	Cocaine addiction_Homo sapiens_hsa05030	1.12746694
40	Basal transcription factors_Homo sapiens_hsa03022	1.12280018
41	Type II diabetes mellitus_Homo sapiens_hsa04930	1.09731683
42	Tryptophan metabolism_Homo sapiens_hsa00380	1.09701994
43	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.09067413
44	Mineral absorption_Homo sapiens_hsa04978	1.07688192
45	Nitrogen metabolism_Homo sapiens_hsa00910	1.06024158
46	Folate biosynthesis_Homo sapiens_hsa00790	1.05363355
47	Long-term depression_Homo sapiens_hsa04730	1.03877131
48	Alzheimers disease_Homo sapiens_hsa05010	0.99342013
49	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.98848269
50	Huntingtons disease_Homo sapiens_hsa05016	0.96979849
51	One carbon pool by folate_Homo sapiens_hsa00670	0.90706897
52	Homologous recombination_Homo sapiens_hsa03440	0.88036440
53	Salivary secretion_Homo sapiens_hsa04970	0.88011126
54	Renin secretion_Homo sapiens_hsa04924	0.86614497
55	cAMP signaling pathway_Homo sapiens_hsa04024	0.83428440
56	Retinol metabolism_Homo sapiens_hsa00830	0.82931320
57	Bile secretion_Homo sapiens_hsa04976	0.80606548
58	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.80116007
59	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.77516321
60	Pancreatic secretion_Homo sapiens_hsa04972	0.75145247
61	Cholinergic synapse_Homo sapiens_hsa04725	0.74440266
62	RNA polymerase_Homo sapiens_hsa03020	0.74013565
63	Peroxisome_Homo sapiens_hsa04146	0.72147799
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.70652160
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.69748944
66	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.69375889
67	Glucagon signaling pathway_Homo sapiens_hsa04922	0.69245320
68	Calcium signaling pathway_Homo sapiens_hsa04020	0.67246117
69	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.66937024
70	Arginine biosynthesis_Homo sapiens_hsa00220	0.66546509
71	Oocyte meiosis_Homo sapiens_hsa04114	0.65681214
72	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.63761782
73	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.62161688
74	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.61973651
75	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.61447608
76	Steroid biosynthesis_Homo sapiens_hsa00100	0.60793125
77	Fanconi anemia pathway_Homo sapiens_hsa03460	0.60381763
78	RNA degradation_Homo sapiens_hsa03018	0.60011152
79	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.57921108
80	Non-homologous end-joining_Homo sapiens_hsa03450	0.56894889
81	Purine metabolism_Homo sapiens_hsa00230	0.55118560
82	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.53272316
83	Chemical carcinogenesis_Homo sapiens_hsa05204	0.53210180
84	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.52485898
85	Metabolic pathways_Homo sapiens_hsa01100	0.52367346
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.52278867
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.52226295
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.51842888
89	Sulfur metabolism_Homo sapiens_hsa00920	0.49384669
90	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.49324844
91	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.49204214
92	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.49096964
93	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48354208
94	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.48221851
95	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.48208976
96	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.47889245
97	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46957836
98	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.46686030
99	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.46580837
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.45990095

FAR2P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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