ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.52464186
2	response to pheromone (GO:0019236)	4.97602188
3	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.30242549
4	pyrimidine nucleobase catabolic process (GO:0006208)	3.94906074
5	cellular ketone body metabolic process (GO:0046950)	3.92124226
6	nucleobase catabolic process (GO:0046113)	3.63257253
7	nephron tubule morphogenesis (GO:0072078)	3.52149419
8	nephron epithelium morphogenesis (GO:0072088)	3.52149419
9	epithelial cilium movement (GO:0003351)	3.46998521
10	ketone body metabolic process (GO:1902224)	3.44621050
11	kidney morphogenesis (GO:0060993)	3.33954814
12	neuronal action potential (GO:0019228)	3.32909567
13	nonmotile primary cilium assembly (GO:0035058)	3.32062669
14	presynaptic membrane assembly (GO:0097105)	3.27599832
15	kynurenine metabolic process (GO:0070189)	3.26899991
16	postsynaptic membrane organization (GO:0001941)	3.25646763
17	reflex (GO:0060004)	3.21022864
18	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.19189393
19	protein polyglutamylation (GO:0018095)	3.15352330
20	neuron cell-cell adhesion (GO:0007158)	3.15329221
21	protein-cofactor linkage (GO:0018065)	3.13879469
22	indole-containing compound catabolic process (GO:0042436)	3.11568367
23	indolalkylamine catabolic process (GO:0046218)	3.11568367
24	tryptophan catabolic process (GO:0006569)	3.11568367
25	primary amino compound metabolic process (GO:1901160)	3.10013947
26	gamma-aminobutyric acid transport (GO:0015812)	3.09979233
27	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.09040693
28	ATP synthesis coupled proton transport (GO:0015986)	3.07534073
29	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.07534073
30	indolalkylamine metabolic process (GO:0006586)	3.05371480
31	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.02333850
32	regulation of glucokinase activity (GO:0033131)	3.00029877
33	regulation of hexokinase activity (GO:1903299)	3.00029877
34	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.96648456
35	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.95971036
36	regulation of cilium movement (GO:0003352)	2.95652306
37	startle response (GO:0001964)	2.95375641
38	hindbrain development (GO:0030902)	2.92578602
39	serotonin metabolic process (GO:0042428)	2.90970830
40	tryptophan metabolic process (GO:0006568)	2.89149286
41	auditory behavior (GO:0031223)	2.88881610
42	presynaptic membrane organization (GO:0097090)	2.88725573
43	adaptation of signaling pathway (GO:0023058)	2.88066893
44	cilium movement (GO:0003341)	2.87956489
45	glycerophospholipid catabolic process (GO:0046475)	2.87866754
46	regulation of action potential (GO:0098900)	2.87798016
47	protein complex biogenesis (GO:0070271)	2.86475928
48	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.85563209
49	dendritic spine morphogenesis (GO:0060997)	2.85160844
50	regulation of synapse structural plasticity (GO:0051823)	2.81743391
51	alanine transport (GO:0032328)	2.80703648
52	preassembly of GPI anchor in ER membrane (GO:0016254)	2.79788196
53	platelet dense granule organization (GO:0060155)	2.79054716
54	urinary tract smooth muscle contraction (GO:0014848)	2.78748133
55	regulation of microtubule-based movement (GO:0060632)	2.78479996
56	retinal cone cell development (GO:0046549)	2.78227436
57	indole-containing compound metabolic process (GO:0042430)	2.78171657
58	fucose catabolic process (GO:0019317)	2.75448963
59	L-fucose metabolic process (GO:0042354)	2.75448963
60	L-fucose catabolic process (GO:0042355)	2.75448963
61	spinal cord motor neuron differentiation (GO:0021522)	2.74581290
62	proline transport (GO:0015824)	2.71700431
63	protein localization to cilium (GO:0061512)	2.71269368
64	renal tubule morphogenesis (GO:0061333)	2.70681552
65	mitochondrial respiratory chain complex assembly (GO:0033108)	2.70160231
66	somite rostral/caudal axis specification (GO:0032525)	2.68919062
67	cornea development in camera-type eye (GO:0061303)	2.68839259
68	respiratory chain complex IV assembly (GO:0008535)	2.68241528
69	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.67210167
70	retinal ganglion cell axon guidance (GO:0031290)	2.66888443
71	axoneme assembly (GO:0035082)	2.66417185
72	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.64420234
73	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.64420234
74	NADH dehydrogenase complex assembly (GO:0010257)	2.64420234
75	cilium or flagellum-dependent cell motility (GO:0001539)	2.61523230
76	vocalization behavior (GO:0071625)	2.60543194
77	cilium organization (GO:0044782)	2.58313012
78	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.58244859
79	synapse assembly (GO:0007416)	2.57353492
80	DNA deamination (GO:0045006)	2.57102023
81	cilium assembly (GO:0042384)	2.54447512
82	cilium morphogenesis (GO:0060271)	2.54213798
83	detection of light stimulus involved in visual perception (GO:0050908)	2.51105587
84	detection of light stimulus involved in sensory perception (GO:0050962)	2.51105587
85	glutamate receptor signaling pathway (GO:0007215)	2.48485210
86	peristalsis (GO:0030432)	2.46605793
87	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.46331943
88	membrane depolarization during action potential (GO:0086010)	2.45926981
89	endocrine pancreas development (GO:0031018)	2.45822781
90	negative regulation of telomere maintenance (GO:0032205)	2.45451284
91	protein localization to synapse (GO:0035418)	2.45199402
92	rhodopsin mediated signaling pathway (GO:0016056)	2.44462695
93	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.43867956
94	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.42642508
95	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.42520177
96	neuron fate determination (GO:0048664)	2.40871689
97	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.40672539
98	behavioral response to ethanol (GO:0048149)	2.40443872
99	innervation (GO:0060384)	2.40251653
100	mechanosensory behavior (GO:0007638)	2.39678285

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.17994663
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.56023161
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.01209057
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.88579841
5	VDR_22108803_ChIP-Seq_LS180_Human	2.57442252
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.55863067
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.49203315
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.47554569
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.33836870
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.20314631
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.19153782
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.18498586
13	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.17497699
14	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.99455072
15	FUS_26573619_Chip-Seq_HEK293_Human	1.97015204
16	REST_21632747_ChIP-Seq_MESCs_Mouse	1.94225670
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.91616339
18	P300_19829295_ChIP-Seq_ESCs_Human	1.91433022
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.91306176
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.91053124
21	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.90192119
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.87233387
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.85680990
24	EWS_26573619_Chip-Seq_HEK293_Human	1.80456807
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.78444317
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.70172856
27	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.69806024
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.63753765
29	AR_21572438_ChIP-Seq_LNCaP_Human	1.57681444
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.55556470
31	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.54026834
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.53919893
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53919893
34	RNF2_27304074_Chip-Seq_NSC_Mouse	1.53883507
35	AR_25329375_ChIP-Seq_VCAP_Human	1.50963307
36	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.49778768
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45537267
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.45078697
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.43723306
40	SMAD4_21799915_ChIP-Seq_A2780_Human	1.42699323
41	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.42402881
42	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.42237499
43	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.41442735
44	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.41198955
45	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40714572
46	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.40694115
47	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.40357800
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.37868143
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.37685839
50	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34657589
51	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.33626658
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.32652980
53	STAT3_23295773_ChIP-Seq_U87_Human	1.32572942
54	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.31834116
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.30967170
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28922698
57	TCF4_23295773_ChIP-Seq_U87_Human	1.28391285
58	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26034039
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.24670334
60	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23778231
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23778231
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23241640
63	CBP_20019798_ChIP-Seq_JUKART_Human	1.23030289
64	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23030289
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22327840
66	MYC_18940864_ChIP-ChIP_HL60_Human	1.21247359
67	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.20993709
68	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.19158756
69	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.18290931
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.17683978
71	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.16862801
72	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15756468
73	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.14981909
74	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.13878539
75	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.11665823
76	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.11080259
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10323759
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10323759
79	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09914421
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09678248
81	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.08974858
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.08800624
83	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08693631
84	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.08485017
85	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07920618
86	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.07278103
87	DROSHA_22980978_ChIP-Seq_HELA_Human	1.05485274
88	NCOR_22424771_ChIP-Seq_293T_Human	1.04790265
89	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01820671
90	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.01775221
91	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.01760738
92	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.01638589
93	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.00424738
94	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99935705
95	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98594506
96	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98445026
97	AR_20517297_ChIP-Seq_VCAP_Human	0.97182061
98	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.96720449
99	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96465248
100	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.95281281

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.97660287
2	MP0001968_abnormal_touch/_nociception	2.50356215
3	MP0003787_abnormal_imprinting	2.37036611
4	MP0005551_abnormal_eye_electrophysiolog	2.34497052
5	MP0002653_abnormal_ependyma_morphology	2.34254724
6	MP0003195_calcinosis	2.28764160
7	MP0004133_heterotaxia	2.23257188
8	MP0009745_abnormal_behavioral_response	2.21284575
9	MP0002837_dystrophic_cardiac_calcinosis	2.15730416
10	MP0003011_delayed_dark_adaptation	2.14622293
11	MP0002638_abnormal_pupillary_reflex	2.12792999
12	MP0002102_abnormal_ear_morphology	2.07138464
13	MP0004043_abnormal_pH_regulation	2.03238244
14	MP0009046_muscle_twitch	2.01117325
15	MP0005645_abnormal_hypothalamus_physiol	2.00263939
16	MP0002736_abnormal_nociception_after	1.96760124
17	MP0003136_yellow_coat_color	1.95962280
18	MP0006072_abnormal_retinal_apoptosis	1.92343734
19	MP0004142_abnormal_muscle_tone	1.91561931
20	MP0002735_abnormal_chemical_nociception	1.90576747
21	MP0002272_abnormal_nervous_system	1.83451290
22	MP0002064_seizures	1.82403298
23	MP0003283_abnormal_digestive_organ	1.81371837
24	MP0005253_abnormal_eye_physiology	1.79850585
25	MP0001986_abnormal_taste_sensitivity	1.78411562
26	MP0000631_abnormal_neuroendocrine_gland	1.78377252
27	MP0002572_abnormal_emotion/affect_behav	1.71740534
28	MP0004885_abnormal_endolymph	1.69400872
29	MP0000569_abnormal_digit_pigmentation	1.67189279
30	MP0005646_abnormal_pituitary_gland	1.59173404
31	MP0002557_abnormal_social/conspecific_i	1.56970883
32	MP0008872_abnormal_physiological_respon	1.56309593
33	MP0004147_increased_porphyrin_level	1.56278319
34	MP0002733_abnormal_thermal_nociception	1.56160949
35	MP0002876_abnormal_thyroid_physiology	1.55995506
36	MP0003880_abnormal_central_pattern	1.53345415
37	MP0001529_abnormal_vocalization	1.53247972
38	MP0003635_abnormal_synaptic_transmissio	1.52502949
39	MP0002938_white_spotting	1.51213220
40	MP0003122_maternal_imprinting	1.50869030
41	MP0002063_abnormal_learning/memory/cond	1.50503067
42	MP0001970_abnormal_pain_threshold	1.49911269
43	MP0005084_abnormal_gallbladder_morpholo	1.48623540
44	MP0000778_abnormal_nervous_system	1.46004936
45	MP0002909_abnormal_adrenal_gland	1.44594499
46	MP0002734_abnormal_mechanical_nocicepti	1.43054264
47	MP0008875_abnormal_xenobiotic_pharmacok	1.40841966
48	MP0001485_abnormal_pinna_reflex	1.40274465
49	MP0001486_abnormal_startle_reflex	1.39496037
50	MP0002067_abnormal_sensory_capabilities	1.38811302
51	MP0004742_abnormal_vestibular_system	1.37605855
52	MP0000427_abnormal_hair_cycle	1.36742214
53	MP0005423_abnormal_somatic_nervous	1.34660354
54	MP0004924_abnormal_behavior	1.33805195
55	MP0005386_behavior/neurological_phenoty	1.33805195
56	MP0005379_endocrine/exocrine_gland_phen	1.31801242
57	MP0001501_abnormal_sleep_pattern	1.29480368
58	MP0002277_abnormal_respiratory_mucosa	1.25063165
59	MP0003890_abnormal_embryonic-extraembry	1.24420475
60	MP0002163_abnormal_gland_morphology	1.24335932
61	MP0001984_abnormal_olfaction	1.16761338
62	MP0002928_abnormal_bile_duct	1.15230604
63	MP0006292_abnormal_olfactory_placode	1.15179156
64	MP0005167_abnormal_blood-brain_barrier	1.13508642
65	MP0004270_analgesia	1.11806222
66	MP0008995_early_reproductive_senescence	1.10116279
67	MP0002184_abnormal_innervation	1.09654566
68	MP0001905_abnormal_dopamine_level	1.09558989
69	MP0000372_irregular_coat_pigmentation	1.09293972
70	MP0003121_genomic_imprinting	1.03536292
71	MP0004019_abnormal_vitamin_homeostasis	1.03119156
72	MP0003137_abnormal_impulse_conducting	1.03017045
73	MP0009379_abnormal_foot_pigmentation	1.02942719
74	MP0005195_abnormal_posterior_eye	1.02570502
75	MP0002751_abnormal_autonomic_nervous	0.98850545
76	MP0001944_abnormal_pancreas_morphology	0.98847196
77	MP0000955_abnormal_spinal_cord	0.98600628
78	MP0000026_abnormal_inner_ear	0.95947068
79	MP0004145_abnormal_muscle_electrophysio	0.95797654
80	MP0002234_abnormal_pharynx_morphology	0.94698348
81	MP0002752_abnormal_somatic_nervous	0.93931845
82	MP0006276_abnormal_autonomic_nervous	0.91237361
83	MP0001919_abnormal_reproductive_system	0.90630751
84	MP0004215_abnormal_myocardial_fiber	0.90607448
85	MP0005410_abnormal_fertilization	0.90206935
86	MP0002882_abnormal_neuron_morphology	0.89897081
87	MP0005389_reproductive_system_phenotype	0.87820236
88	MP0000383_abnormal_hair_follicle	0.86460549
89	MP0005085_abnormal_gallbladder_physiolo	0.86281751
90	MP0001502_abnormal_circadian_rhythm	0.84390092
91	MP0001440_abnormal_grooming_behavior	0.84060370
92	MP0010329_abnormal_lipoprotein_level	0.83900570
93	MP0005448_abnormal_energy_balance	0.81421448
94	MP0000647_abnormal_sebaceous_gland	0.80004253
95	MP0002693_abnormal_pancreas_physiology	0.79836527
96	MP0003698_abnormal_male_reproductive	0.78806163
97	MP0003718_maternal_effect	0.75679559
98	MP0005636_abnormal_mineral_homeostasis	0.75596127
99	MP0005332_abnormal_amino_acid	0.75318131
100	MP0002139_abnormal_hepatobiliary_system	0.74240282

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.10905015
2	Abnormality of midbrain morphology (HP:0002418)	3.92569270
3	Molar tooth sign on MRI (HP:0002419)	3.92569270
4	Pancreatic fibrosis (HP:0100732)	3.78673994
5	True hermaphroditism (HP:0010459)	3.66898765
6	Nephronophthisis (HP:0000090)	3.62424838
7	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.35401395
8	Abnormality of alanine metabolism (HP:0010916)	3.35401395
9	Hyperalaninemia (HP:0003348)	3.35401395
10	Hyperventilation (HP:0002883)	3.25022596
11	Congenital stationary night blindness (HP:0007642)	3.23117793
12	Medial flaring of the eyebrow (HP:0010747)	3.16118255
13	Type II lissencephaly (HP:0007260)	3.00624553
14	Abnormality of the renal medulla (HP:0100957)	2.96828015
15	Hypothermia (HP:0002045)	2.94587301
16	Gait imbalance (HP:0002141)	2.89793582
17	Pendular nystagmus (HP:0012043)	2.84997719
18	Attenuation of retinal blood vessels (HP:0007843)	2.77383943
19	Large for gestational age (HP:0001520)	2.71496067
20	Chronic hepatic failure (HP:0100626)	2.68103553
21	Abnormal drinking behavior (HP:0030082)	2.67472258
22	Polydipsia (HP:0001959)	2.67472258
23	Cystic liver disease (HP:0006706)	2.67056458
24	Progressive inability to walk (HP:0002505)	2.62969525
25	Inability to walk (HP:0002540)	2.62033552
26	Congenital primary aphakia (HP:0007707)	2.61582516
27	Aplasia/hypoplasia of the uterus (HP:0008684)	2.53126867
28	Abnormality of the renal cortex (HP:0011035)	2.50366414
29	Congenital, generalized hypertrichosis (HP:0004540)	2.49966665
30	Broad-based gait (HP:0002136)	2.49410287
31	Lissencephaly (HP:0001339)	2.47740482
32	Abnormal respiratory epithelium morphology (HP:0012253)	2.40388903
33	Abnormal respiratory motile cilium morphology (HP:0005938)	2.40388903
34	Nephrogenic diabetes insipidus (HP:0009806)	2.39960242
35	Sclerocornea (HP:0000647)	2.39298281
36	Tubular atrophy (HP:0000092)	2.38940281
37	Febrile seizures (HP:0002373)	2.35305773
38	Hypoplasia of the uterus (HP:0000013)	2.33971491
39	Concave nail (HP:0001598)	2.31697467
40	Intestinal atresia (HP:0011100)	2.31237413
41	Hemiparesis (HP:0001269)	2.31110462
42	Optic nerve hypoplasia (HP:0000609)	2.30407420
43	Genital tract atresia (HP:0001827)	2.29702378
44	Vaginal atresia (HP:0000148)	2.26735501
45	Abolished electroretinogram (ERG) (HP:0000550)	2.23516016
46	Acute necrotizing encephalopathy (HP:0006965)	2.23156304
47	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.23072299
48	Absent/shortened dynein arms (HP:0200106)	2.23072299
49	Male pseudohermaphroditism (HP:0000037)	2.22744614
50	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.20323857
51	Abnormal rod and cone electroretinograms (HP:0008323)	2.19801057
52	Focal motor seizures (HP:0011153)	2.19086583
53	Decreased circulating renin level (HP:0003351)	2.16662086
54	Birth length less than 3rd percentile (HP:0003561)	2.15483019
55	Anencephaly (HP:0002323)	2.14541602
56	Increased hepatocellular lipid droplets (HP:0006565)	2.13753545
57	Bilateral microphthalmos (HP:0007633)	2.13533390
58	Cerebellar dysplasia (HP:0007033)	2.12968822
59	Agitation (HP:0000713)	2.12561600
60	Mitochondrial inheritance (HP:0001427)	2.12510018
61	Furrowed tongue (HP:0000221)	2.09701097
62	Bony spicule pigmentary retinopathy (HP:0007737)	2.07048441
63	Progressive cerebellar ataxia (HP:0002073)	2.05466707
64	Lipid accumulation in hepatocytes (HP:0006561)	2.03965452
65	Limb dystonia (HP:0002451)	2.02221656
66	Progressive macrocephaly (HP:0004481)	2.02131668
67	Gaze-evoked nystagmus (HP:0000640)	1.97242511
68	Acute encephalopathy (HP:0006846)	1.97163615
69	3-Methylglutaconic aciduria (HP:0003535)	1.95802286
70	Abnormal ciliary motility (HP:0012262)	1.95307875
71	Dialeptic seizures (HP:0011146)	1.94802612
72	Pachygyria (HP:0001302)	1.94759231
73	Hyperglycinuria (HP:0003108)	1.94394426
74	Increased CSF lactate (HP:0002490)	1.94136334
75	Atonic seizures (HP:0010819)	1.94081197
76	Renal cortical cysts (HP:0000803)	1.92988799
77	Polyuria (HP:0000103)	1.92457385
78	Anophthalmia (HP:0000528)	1.89491675
79	Patellar aplasia (HP:0006443)	1.88822176
80	Optic disc pallor (HP:0000543)	1.88737586
81	Ketoacidosis (HP:0001993)	1.87408805
82	Tachypnea (HP:0002789)	1.85335142
83	Severe muscular hypotonia (HP:0006829)	1.84615307
84	Absence seizures (HP:0002121)	1.83701785
85	Increased corneal curvature (HP:0100692)	1.81693985
86	Keratoconus (HP:0000563)	1.81693985
87	Glycosuria (HP:0003076)	1.79355544
88	Abnormality of urine glucose concentration (HP:0011016)	1.79355544
89	Methylmalonic acidemia (HP:0002912)	1.77652003
90	Poor coordination (HP:0002370)	1.75815922
91	Aplasia/Hypoplasia of the patella (HP:0006498)	1.75696042
92	Focal seizures (HP:0007359)	1.74528695
93	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.74367712
94	Postaxial hand polydactyly (HP:0001162)	1.74305084
95	Protruding tongue (HP:0010808)	1.72792691
96	Chorioretinal atrophy (HP:0000533)	1.71196072
97	Polyphagia (HP:0002591)	1.70685434
98	Renal Fanconi syndrome (HP:0001994)	1.70271620
99	Hypsarrhythmia (HP:0002521)	1.70258527
100	Abnormal biliary tract physiology (HP:0012439)	1.68840872

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.84486780
2	PNCK	3.68535977
3	CASK	3.52630498
4	WNK4	3.39618387
5	INSRR	3.30661246
6	MAP4K2	3.25394034
7	MARK1	3.11521451
8	WNK3	2.97740235
9	MAP3K4	2.76571690
10	ADRBK2	2.68435599
11	DAPK2	2.67305890
12	MAPK13	2.20401375
13	BMPR1B	2.09837495
14	ZAK	2.07057914
15	TLK1	2.02571121
16	GRK1	2.02455617
17	ACVR1B	1.77175113
18	MAP2K7	1.66214749
19	DYRK2	1.59771888
20	PINK1	1.59109267
21	MAPK15	1.56664525
22	STK39	1.56627893
23	OXSR1	1.48104783
24	NTRK3	1.41363101
25	PRKCG	1.37339646
26	CAMKK2	1.36893858
27	TAOK3	1.29687122
28	TSSK6	1.17571617
29	MAP2K6	1.15939033
30	PAK3	1.12744437
31	NUAK1	1.07382070
32	PHKG1	1.05634517
33	PHKG2	1.05634517
34	WEE1	1.01239337
35	TNIK	0.97209218
36	NTRK2	0.90243075
37	TXK	0.87377650
38	PRKCE	0.84656052
39	ADRBK1	0.80647083
40	MAPKAPK3	0.79335460
41	EPHA3	0.78167862
42	TIE1	0.77306118
43	FGFR2	0.74003628
44	PTK2B	0.71820173
45	CSNK1G2	0.71479074
46	MUSK	0.66210672
47	BCR	0.65886259
48	STK11	0.64557183
49	AKT3	0.64097852
50	CAMK2A	0.62424930
51	MAP2K4	0.62056642
52	WNK1	0.61948098
53	MKNK2	0.61665321
54	SIK2	0.61652052
55	CAMK1G	0.61562374
56	PASK	0.59937068
57	TRIM28	0.58565551
58	VRK1	0.58472515
59	LIMK1	0.58323781
60	BCKDK	0.57899857
61	CAMK1D	0.57393140
62	TGFBR1	0.57100614
63	CSNK1G1	0.53152441
64	DYRK3	0.52899753
65	UHMK1	0.52731802
66	CSNK1G3	0.51205786
67	PIK3CA	0.50091785
68	CAMKK1	0.49107781
69	CAMK1	0.48648579
70	PRKACA	0.48088628
71	STK38L	0.47147120
72	PLK2	0.46257173
73	STK16	0.44312635
74	SGK2	0.43685574
75	IRAK1	0.43538762
76	PLK3	0.43296208
77	PRKCZ	0.42642150
78	MAPKAPK5	0.42382320
79	PRKCQ	0.42366433
80	RPS6KA5	0.41942682
81	ERBB3	0.41534766
82	PKN1	0.39617671
83	NLK	0.39469388
84	OBSCN	0.39093405
85	PRKAA1	0.38720782
86	SGK494	0.37412067
87	SGK223	0.37412067
88	CSNK1A1L	0.37381542
89	EPHA4	0.36243798
90	MINK1	0.35512199
91	CSNK1D	0.31967550
92	GRK7	0.31614471
93	CDK5	0.31487286
94	NEK2	0.30426830
95	CSNK1A1	0.30079468
96	DYRK1B	0.29920217
97	DYRK1A	0.29812399
98	PRKCA	0.29477839
99	PAK6	0.28421432
100	ERBB2	0.28387954

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.25068903
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.23487804
3	Nicotine addiction_Homo sapiens_hsa05033	2.81706595
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.81681837
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.71452345
6	Butanoate metabolism_Homo sapiens_hsa00650	2.66161995
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.62312345
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.60551828
9	Phototransduction_Homo sapiens_hsa04744	2.48974007
10	Caffeine metabolism_Homo sapiens_hsa00232	2.29942973
11	Parkinsons disease_Homo sapiens_hsa05012	2.14085276
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.13415659
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.05593316
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.02653523
15	Protein export_Homo sapiens_hsa03060	1.92779554
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.90217623
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.89745236
18	Taste transduction_Homo sapiens_hsa04742	1.87656092
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.82789531
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.66068906
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.59934991
22	Morphine addiction_Homo sapiens_hsa05032	1.56735268
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.53204231
24	Alzheimers disease_Homo sapiens_hsa05010	1.53037324
25	GABAergic synapse_Homo sapiens_hsa04727	1.49005220
26	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.48963536
27	Huntingtons disease_Homo sapiens_hsa05016	1.40541605
28	Insulin secretion_Homo sapiens_hsa04911	1.38606397
29	Olfactory transduction_Homo sapiens_hsa04740	1.33384058
30	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.31452040
31	Glutamatergic synapse_Homo sapiens_hsa04724	1.30127397
32	Circadian entrainment_Homo sapiens_hsa04713	1.25914608
33	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.25464649
34	Basal transcription factors_Homo sapiens_hsa03022	1.25092850
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.23790923
36	RNA polymerase_Homo sapiens_hsa03020	1.23661431
37	Serotonergic synapse_Homo sapiens_hsa04726	1.15690374
38	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.15686042
39	Peroxisome_Homo sapiens_hsa04146	1.08863426
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.07457246
41	Collecting duct acid secretion_Homo sapiens_hsa04966	1.03893469
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.03514176
43	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01983165
44	ABC transporters_Homo sapiens_hsa02010	1.00347266
45	Propanoate metabolism_Homo sapiens_hsa00640	0.96465257
46	Homologous recombination_Homo sapiens_hsa03440	0.94444546
47	Cocaine addiction_Homo sapiens_hsa05030	0.94112549
48	Steroid biosynthesis_Homo sapiens_hsa00100	0.92850389
49	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.91277676
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90018065
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.89810285
52	Amphetamine addiction_Homo sapiens_hsa05031	0.85650229
53	Fanconi anemia pathway_Homo sapiens_hsa03460	0.84419106
54	Dopaminergic synapse_Homo sapiens_hsa04728	0.82919418
55	Fat digestion and absorption_Homo sapiens_hsa04975	0.82820296
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82514799
57	Ribosome_Homo sapiens_hsa03010	0.80868233
58	Retinol metabolism_Homo sapiens_hsa00830	0.76739650
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76231321
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73652255
61	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.71383888
62	Calcium signaling pathway_Homo sapiens_hsa04020	0.69992129
63	Histidine metabolism_Homo sapiens_hsa00340	0.63980602
64	Long-term depression_Homo sapiens_hsa04730	0.62166629
65	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.61846018
66	Mineral absorption_Homo sapiens_hsa04978	0.61509535
67	Salivary secretion_Homo sapiens_hsa04970	0.60618527
68	Sulfur metabolism_Homo sapiens_hsa00920	0.59846949
69	Metabolic pathways_Homo sapiens_hsa01100	0.58706268
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.58226489
71	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.58113871
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.57039535
73	Axon guidance_Homo sapiens_hsa04360	0.55868527
74	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.54941079
75	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.54088855
76	RNA degradation_Homo sapiens_hsa03018	0.51070695
77	One carbon pool by folate_Homo sapiens_hsa00670	0.49577511
78	cAMP signaling pathway_Homo sapiens_hsa04024	0.48815195
79	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.46974319
80	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.46834414
81	Circadian rhythm_Homo sapiens_hsa04710	0.45960993
82	Bile secretion_Homo sapiens_hsa04976	0.45238686
83	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.42640337
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42555284
85	Regulation of autophagy_Homo sapiens_hsa04140	0.42108172
86	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.41613393
87	Cholinergic synapse_Homo sapiens_hsa04725	0.41031996
88	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.40553987
89	Basal cell carcinoma_Homo sapiens_hsa05217	0.40107468
90	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.39512201
91	Purine metabolism_Homo sapiens_hsa00230	0.38828389
92	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.37215702
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.37134987
94	Sulfur relay system_Homo sapiens_hsa04122	0.35866417
95	Gastric acid secretion_Homo sapiens_hsa04971	0.35252394
96	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.34652999
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.34142670
98	Glycerolipid metabolism_Homo sapiens_hsa00561	0.30940210
99	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.30607274
100	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.29480905

FAR2P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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