FAR2P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.63178274
2nuclear pore organization (GO:0006999)5.91737963
3DNA replication checkpoint (GO:0000076)5.38443605
4diterpenoid biosynthetic process (GO:0016102)5.35423393
5synapsis (GO:0007129)5.30066585
6DNA topological change (GO:0006265)5.16178146
7iron ion import (GO:0097286)5.07534342
8terpenoid biosynthetic process (GO:0016114)5.03488243
9regulation of histone H3-K4 methylation (GO:0051569)5.03473295
10regulation of RNA export from nucleus (GO:0046831)5.03038420
11DNA synthesis involved in DNA repair (GO:0000731)5.00425442
12pore complex assembly (GO:0046931)4.99461511
13regulation of translational fidelity (GO:0006450)4.80712356
14regulation of histone H3-K27 methylation (GO:0061085)4.56752899
15centriole replication (GO:0007099)4.56213799
16regulation of centriole replication (GO:0046599)4.46161126
17resolution of meiotic recombination intermediates (GO:0000712)4.41077673
18DNA replication initiation (GO:0006270)4.40199499
19definitive hemopoiesis (GO:0060216)4.27561632
20mitotic nuclear envelope disassembly (GO:0007077)4.24321506
21intra-S DNA damage checkpoint (GO:0031573)4.24267781
22replication fork processing (GO:0031297)4.20475155
23detection of chemical stimulus involved in sensory perception of smell (GO:0050911)4.08350417
24sister chromatid segregation (GO:0000819)4.04276343
25negative regulation of histone methylation (GO:0031061)4.00790087
26nuclear envelope disassembly (GO:0051081)3.96517680
27membrane disassembly (GO:0030397)3.96517680
28sensory perception of smell (GO:0007608)3.92050632
29retinal metabolic process (GO:0042574)3.91139086
30meiotic chromosome segregation (GO:0045132)3.89519536
31negative regulation of fatty acid biosynthetic process (GO:0045717)3.88688633
32DNA unwinding involved in DNA replication (GO:0006268)3.85762024
33DNA methylation involved in gamete generation (GO:0043046)3.84085105
34centriole assembly (GO:0098534)3.81141507
35regulation of nucleobase-containing compound transport (GO:0032239)3.79389711
36homocysteine metabolic process (GO:0050667)3.78587627
37mitotic sister chromatid segregation (GO:0000070)3.75228441
38protoporphyrinogen IX metabolic process (GO:0046501)3.74250213
39regulation of histone methylation (GO:0031060)3.68898511
40regulation of histone H3-K9 methylation (GO:0051570)3.63974281
41tetrahydrofolate metabolic process (GO:0046653)3.56962859
42mitotic chromosome condensation (GO:0007076)3.54137270
43purine nucleobase biosynthetic process (GO:0009113)3.51711962
44DNA strand elongation involved in DNA replication (GO:0006271)3.51136227
45biotin metabolic process (GO:0006768)3.42239562
46positive regulation of histone H3-K4 methylation (GO:0051571)3.37593102
47chromosome organization involved in meiosis (GO:0070192)3.37498459
48DNA strand elongation (GO:0022616)3.33444585
49nucleobase biosynthetic process (GO:0046112)3.30862825
50vitamin A metabolic process (GO:0006776)3.28656923
51cysteine metabolic process (GO:0006534)3.27449651
52microtubule depolymerization (GO:0007019)3.25490815
53regulation of gene expression by genetic imprinting (GO:0006349)3.25043636
54tRNA aminoacylation for protein translation (GO:0006418)3.23762667
55erythrocyte maturation (GO:0043249)3.23366061
56telomere maintenance via semi-conservative replication (GO:0032201)3.22760797
57mitotic recombination (GO:0006312)3.21397856
58viral mRNA export from host cell nucleus (GO:0046784)3.20797486
59positive regulation of dendritic spine morphogenesis (GO:0061003)3.17898209
60telomere maintenance via recombination (GO:0000722)3.15167471
61maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.14806363
62regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.12438703
63regulation of centrosome cycle (GO:0046605)3.11650598
64monoubiquitinated protein deubiquitination (GO:0035520)3.10794702
65response to vitamin A (GO:0033189)3.09760385
66amino acid activation (GO:0043038)3.09328050
67tRNA aminoacylation (GO:0043039)3.09328050
68chromosome segregation (GO:0007059)3.08881451
69folic acid metabolic process (GO:0046655)3.07977691
70male meiosis (GO:0007140)3.06808609
71granulocyte differentiation (GO:0030851)3.05793249
72positive regulation of histone methylation (GO:0031062)3.04963271
73kinetochore organization (GO:0051383)3.04315037
74protoporphyrinogen IX biosynthetic process (GO:0006782)3.01849285
75protein export from nucleus (GO:0006611)3.01290519
76DNA conformation change (GO:0071103)3.00795324
77chromosome condensation (GO:0030261)2.99261938
78negative regulation of potassium ion transmembrane transport (GO:1901380)2.93034239
79DNA geometric change (GO:0032392)2.90908295
80regulation of translational elongation (GO:0006448)2.90306176
81poly(A)+ mRNA export from nucleus (GO:0016973)2.89950723
82face development (GO:0060324)2.89623849
83pyrimidine dimer repair (GO:0006290)2.89106182
84reciprocal DNA recombination (GO:0035825)2.86179339
85reciprocal meiotic recombination (GO:0007131)2.86179339
86DNA duplex unwinding (GO:0032508)2.85905016
87regulation of centrosome duplication (GO:0010824)2.85244712
88DNA strand renaturation (GO:0000733)2.82179295
89gas transport (GO:0015669)2.81749103
90DNA packaging (GO:0006323)2.79664987
91isoprenoid biosynthetic process (GO:0008299)2.78603546
92folic acid-containing compound metabolic process (GO:0006760)2.77634965
93pre-miRNA processing (GO:0031054)2.77456901
94response to UV-C (GO:0010225)2.75620457
95histone H3-K9 demethylation (GO:0033169)2.72535956
96folic acid-containing compound biosynthetic process (GO:0009396)2.71491477
97double-strand break repair via homologous recombination (GO:0000724)2.69319947
98mitotic G2/M transition checkpoint (GO:0044818)2.67869201
99kinetochore assembly (GO:0051382)2.67346276
100nuclear envelope organization (GO:0006998)2.65658643

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.24714166
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.91725792
3AR_21909140_ChIP-Seq_LNCAP_Human3.17976123
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.09929128
5NCOR1_26117541_ChIP-Seq_K562_Human2.83281037
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.79919039
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.75144388
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.69446210
9VDR_22108803_ChIP-Seq_LS180_Human2.67719692
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.65420935
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.65359418
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61434602
13GATA1_19941826_ChIP-Seq_K562_Human2.56431650
14ZNF263_19887448_ChIP-Seq_K562_Human2.43043122
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.33085603
16GATA1_22025678_ChIP-Seq_K562_Human2.29812800
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27621932
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.21180624
19KDM5A_27292631_Chip-Seq_BREAST_Human2.19067596
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.11826399
21GATA2_19941826_ChIP-Seq_K562_Human2.08709935
22PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.08587042
23E2F7_22180533_ChIP-Seq_HELA_Human10.0292141
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.97576675
25WT1_19549856_ChIP-ChIP_CCG9911_Human1.88569524
26YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87730739
27ELK1_19687146_ChIP-ChIP_HELA_Human1.83660080
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.80458921
29XRN2_22483619_ChIP-Seq_HELA_Human1.72754072
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71884835
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.63967181
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60243715
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56001369
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55319523
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55189885
36TTF2_22483619_ChIP-Seq_HELA_Human1.54112234
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52310407
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.51999342
39CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.50938598
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50007522
41SPI1_23127762_ChIP-Seq_K562_Human1.49646629
42DCP1A_22483619_ChIP-Seq_HELA_Human1.49563191
43CHD1_26751641_Chip-Seq_LNCaP_Human1.42421780
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40283832
45CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.40060329
46GABP_19822575_ChIP-Seq_HepG2_Human1.39933443
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38894102
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.38869521
49ER_23166858_ChIP-Seq_MCF-7_Human1.34080476
50E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.31263084
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30699379
52FOXP3_21729870_ChIP-Seq_TREG_Human1.30295273
53VDR_23849224_ChIP-Seq_CD4+_Human1.29369359
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.28223024
55ZNF274_21170338_ChIP-Seq_K562_Hela1.26705962
56AR_21572438_ChIP-Seq_LNCaP_Human1.22446366
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20811337
58SCL_19346495_ChIP-Seq_HPC-7_Human1.20575114
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18316300
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16734791
61IGF1R_20145208_ChIP-Seq_DFB_Human1.15253368
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10746677
63PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09436733
64FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.04537513
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04313537
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04000881
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03843491
68ETV1_20927104_ChIP-Seq_GIST48_Human1.03520847
69AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01783393
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01332169
71CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00738765
72PHF8_20622853_ChIP-Seq_HELA_Human1.00102255
73E2F1_17053090_ChIP-ChIP_MCF-7_Human0.97966495
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96759210
75CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96349873
76E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93857472
77EWS_26573619_Chip-Seq_HEK293_Human0.93238697
78NFYB_21822215_ChIP-Seq_K562_Human0.91835143
79GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90855307
80ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89975605
81CBX2_22325352_ChIP-Seq_293T-Rex_Human0.89018112
82GATA6_21074721_ChIP-Seq_CACO-2_Human0.88741767
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88186000
84RBPJ_21746931_ChIP-Seq_IB4_Human0.86980446
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86206953
86FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.84854261
87HNFA_21074721_ChIP-Seq_CACO-2_Human0.83272997
88PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.80816398
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.80278346
90GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.79322700
91MYC_18940864_ChIP-ChIP_HL60_Human0.78276847
92NFYA_21822215_ChIP-Seq_K562_Human0.75734809
93FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.74416506
94TP63_19390658_ChIP-ChIP_HaCaT_Human0.74178865
95TBX5_21415370_ChIP-Seq_HL-1_Mouse0.72422439
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.72320435
97POU3F2_20337985_ChIP-ChIP_501MEL_Human0.72207170
98CIITA_25753668_ChIP-Seq_RAJI_Human0.69847112
99TBL1_22424771_ChIP-Seq_293T_Human0.68903790
100GATA4_21415370_ChIP-Seq_HL-1_Mouse0.68795038

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence5.86014225
2MP0008057_abnormal_DNA_replication4.65384485
3MP0008058_abnormal_DNA_repair3.40598410
4MP0004147_increased_porphyrin_level3.37978418
5MP0010094_abnormal_chromosome_stability3.24984971
6MP0003111_abnormal_nucleus_morphology2.86438631
7MP0005083_abnormal_biliary_tract2.80176037
8MP0004957_abnormal_blastocyst_morpholog2.70535708
9MP0003786_premature_aging2.60815498
10MP0009697_abnormal_copulation2.52208667
11MP0000678_abnormal_parathyroid_gland2.48960556
12MP0002132_abnormal_respiratory_system2.04643558
13MP0003656_abnormal_erythrocyte_physiolo1.96598795
14MP0003077_abnormal_cell_cycle1.94406938
15MP0003693_abnormal_embryo_hatching1.90443007
16MP0005451_abnormal_body_composition1.89972883
17MP0003718_maternal_effect1.87445277
18MP0002638_abnormal_pupillary_reflex1.85696920
19MP0008932_abnormal_embryonic_tissue1.80863684
20MP0008775_abnormal_heart_ventricle1.79870306
21MP0003890_abnormal_embryonic-extraembry1.77559780
22MP0001929_abnormal_gametogenesis1.70018031
23MP0010307_abnormal_tumor_latency1.66583284
24MP0002210_abnormal_sex_determination1.61723271
25MP0001873_stomach_inflammation1.56469680
26MP0005167_abnormal_blood-brain_barrier1.55956545
27MP0004043_abnormal_pH_regulation1.53970901
28MP0003698_abnormal_male_reproductive1.50711746
29MP0001697_abnormal_embryo_size1.49762257
30MP0005647_abnormal_sex_gland1.47969065
31MP0005410_abnormal_fertilization1.47650878
32MP0003984_embryonic_growth_retardation1.44254696
33MP0002088_abnormal_embryonic_growth/wei1.42521879
34MP0001730_embryonic_growth_arrest1.40607744
35MP0003195_calcinosis1.39712037
36MP0005380_embryogenesis_phenotype1.38056880
37MP0001672_abnormal_embryogenesis/_devel1.38056880
38MP0002234_abnormal_pharynx_morphology1.35225387
39MP0005397_hematopoietic_system_phenotyp1.26190549
40MP0001545_abnormal_hematopoietic_system1.26190549
41MP0001502_abnormal_circadian_rhythm1.23311936
42MP0003705_abnormal_hypodermis_morpholog1.20202869
43MP0003011_delayed_dark_adaptation1.19796215
44MP0005636_abnormal_mineral_homeostasis1.19722955
45MP0004145_abnormal_muscle_electrophysio1.19053000
46MP0000313_abnormal_cell_death1.18159211
47MP0000653_abnormal_sex_gland1.16716396
48MP0002269_muscular_atrophy1.16239239
49MP0001145_abnormal_male_reproductive1.15912009
50MP0002080_prenatal_lethality1.14498094
51MP0003385_abnormal_body_wall1.10320294
52MP0000350_abnormal_cell_proliferation1.09509822
53MP0002160_abnormal_reproductive_system1.09469410
54MP0001661_extended_life_span1.06030307
55MP0002086_abnormal_extraembryonic_tissu1.05847074
56MP0002084_abnormal_developmental_patter1.04589760
57MP0006035_abnormal_mitochondrial_morpho1.03639646
58MP0005646_abnormal_pituitary_gland1.03624396
59MP0003943_abnormal_hepatobiliary_system1.01785381
60MP0004134_abnormal_chest_morphology1.01093246
61MP0009703_decreased_birth_body1.00983581
62MP0001666_abnormal_nutrient_absorption1.00669857
63MP0002249_abnormal_larynx_morphology1.00470948
64MP0004233_abnormal_muscle_weight0.97767533
65MP0005076_abnormal_cell_differentiation0.97361864
66MP0000358_abnormal_cell_content/0.96966735
67MP0008877_abnormal_DNA_methylation0.96395184
68MP0003937_abnormal_limbs/digits/tail_de0.95195800
69MP0002085_abnormal_embryonic_tissue0.94860307
70MP0004019_abnormal_vitamin_homeostasis0.92768085
71MP0003942_abnormal_urinary_system0.92576462
72MP0003699_abnormal_female_reproductive0.91444547
73MP0001529_abnormal_vocalization0.90378635
74MP0003806_abnormal_nucleotide_metabolis0.89857969
75MP0002161_abnormal_fertility/fecundity0.89857457
76MP0002736_abnormal_nociception_after0.88785099
77MP0004197_abnormal_fetal_growth/weight/0.88062832
78MP0000631_abnormal_neuroendocrine_gland0.87946270
79MP0004264_abnormal_extraembryonic_tissu0.85060311
80MP0003646_muscle_fatigue0.84228415
81MP0003186_abnormal_redox_activity0.80881266
82MP0003935_abnormal_craniofacial_develop0.79774374
83MP0001764_abnormal_homeostasis0.77398208
84MP0001119_abnormal_female_reproductive0.74440139
85MP0000647_abnormal_sebaceous_gland0.74393256
86MP0003936_abnormal_reproductive_system0.74187877
87MP0008007_abnormal_cellular_replicative0.71006037
88MP0000266_abnormal_heart_morphology0.70596669
89MP0006036_abnormal_mitochondrial_physio0.68738074
90MP0004084_abnormal_cardiac_muscle0.68146288
91MP0005389_reproductive_system_phenotype0.67187636
92MP0005408_hypopigmentation0.66667554
93MP0000609_abnormal_liver_physiology0.65861040
94MP0001968_abnormal_touch/_nociception0.65497434
95MP0008770_decreased_survivor_rate0.64236867
96MP0002019_abnormal_tumor_incidence0.64109536
97MP0003567_abnormal_fetal_cardiomyocyte0.63383769
98MP0000613_abnormal_salivary_gland0.60954715
99MP0010630_abnormal_cardiac_muscle0.60720243
100MP0005395_other_phenotype0.60572148

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.83551343
2Chromsome breakage (HP:0040012)4.78134889
3Truncus arteriosus (HP:0001660)4.76217479
4Hyperthyroidism (HP:0000836)4.54673142
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.43006993
6Abnormal gallbladder physiology (HP:0012438)4.32165555
7Cholecystitis (HP:0001082)4.32165555
8Reticulocytosis (HP:0001923)4.00608749
9Seborrheic dermatitis (HP:0001051)3.60179202
10Acute myeloid leukemia (HP:0004808)3.58928813
11Abnormality of reticulocytes (HP:0004312)3.48281902
12Abnormality of homocysteine metabolism (HP:0010919)3.46344399
13Homocystinuria (HP:0002156)3.46344399
14Ankyloglossia (HP:0010296)3.38493174
15Hypoparathyroidism (HP:0000829)3.35167209
16Bowel incontinence (HP:0002607)3.27233065
17Polycythemia (HP:0001901)3.16849370
18Duplicated collecting system (HP:0000081)3.16259858
19Abnormality of DNA repair (HP:0003254)3.14783991
20Abnormality of cochlea (HP:0000375)3.14631987
21Abnormal large intestine physiology (HP:0012700)3.14217646
22Aplasia/Hypoplasia of the earlobes (HP:0009906)3.10079826
23Abnormal hair whorl (HP:0010721)3.03082056
24Abnormality of glycolysis (HP:0004366)3.00243697
25Increased serum pyruvate (HP:0003542)2.93502382
26Abnormality of the renal collecting system (HP:0004742)2.78614235
27Breast hypoplasia (HP:0003187)2.72471718
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.72459042
29Poikilocytosis (HP:0004447)2.71819652
30Acanthocytosis (HP:0001927)2.71736696
31Hypertensive crisis (HP:0100735)2.71412459
32Ileus (HP:0002595)2.67919713
33Sandal gap (HP:0001852)2.62254114
34Neoplasm of the oral cavity (HP:0100649)2.60928161
35Abnormality of the tricuspid valve (HP:0001702)2.59679237
36Abnormality of chromosome stability (HP:0003220)2.57318999
37Abnormality of the preputium (HP:0100587)2.54787672
38Pili torti (HP:0003777)2.54702460
39Atelectasis (HP:0100750)2.54056040
40Morphological abnormality of the inner ear (HP:0011390)2.49744644
41Septate vagina (HP:0001153)2.49359508
42Upper limb muscle weakness (HP:0003484)2.47543191
43Duodenal stenosis (HP:0100867)2.47510519
44Small intestinal stenosis (HP:0012848)2.47510519
45Aplasia/Hypoplasia of the sternum (HP:0006714)2.45379074
46Meckel diverticulum (HP:0002245)2.44381073
47Abnormality of the heme biosynthetic pathway (HP:0010472)2.41682075
48Abnormality of the ileum (HP:0001549)2.41102255
49Abnormally folded helix (HP:0008544)2.38250845
50Reticulocytopenia (HP:0001896)2.37814114
51Abnormality of the fingertips (HP:0001211)2.33768844
52Cerebellar dysplasia (HP:0007033)2.33431723
53Concave nail (HP:0001598)2.28742699
54Type II lissencephaly (HP:0007260)2.25630755
55Myelodysplasia (HP:0002863)2.21811873
56Hypoplasia of the pons (HP:0012110)2.19952463
57Abnormality of the carotid arteries (HP:0005344)2.14602181
58Abnormal hair laboratory examination (HP:0003328)2.11236901
59Abnormality of oral frenula (HP:0000190)2.11028713
60Patellar dislocation (HP:0002999)2.10664645
61Sparse lateral eyebrow (HP:0005338)2.10651133
62Breech presentation (HP:0001623)2.08893714
63Neoplasm of the small intestine (HP:0100833)2.07245514
64Overlapping toe (HP:0001845)2.06902875
65Capillary hemangiomas (HP:0005306)2.06385641
66Hyperbilirubinemia (HP:0002904)2.06315938
67Facial hemangioma (HP:0000329)2.06286255
68Increased nuchal translucency (HP:0010880)2.04144500
69Abnormality of the pons (HP:0007361)2.03492686
70Overfolded helix (HP:0000396)2.03411305
71Flat cornea (HP:0007720)2.02783135
72Sloping forehead (HP:0000340)2.02049584
73Ectopic kidney (HP:0000086)1.98984768
74Pallor (HP:0000980)1.95914920
75Protruding tongue (HP:0010808)1.94207034
76Cholelithiasis (HP:0001081)1.92187505
77Meningioma (HP:0002858)1.90627118
78Secondary amenorrhea (HP:0000869)1.86706935
79Abnormality of the duodenum (HP:0002246)1.86497842
80Gonadotropin excess (HP:0000837)1.83810759
81Arteriovenous malformation (HP:0100026)1.82468612
82Abnormal hemoglobin (HP:0011902)1.79028599
83Abnormality of the labia minora (HP:0012880)1.78722284
84Polycystic kidney dysplasia (HP:0000113)1.77368344
85Hypoplastic iliac wings (HP:0002866)1.77010532
86Abnormal gallbladder morphology (HP:0012437)1.76657565
87Pancreatic cysts (HP:0001737)1.74761192
88Abnormality of the gallbladder (HP:0005264)1.74333401
89Absent thumb (HP:0009777)1.74053432
90Impulsivity (HP:0100710)1.71073871
91Hypoplastic labia majora (HP:0000059)1.70882064
92Cheekbone underdevelopment (HP:0010669)1.70803091
93Prolonged QT interval (HP:0001657)1.70213436
94Entropion (HP:0000621)1.68925237
95Nonimmune hydrops fetalis (HP:0001790)1.68849406
96Attention deficit hyperactivity disorder (HP:0007018)1.68379821
97Cafe-au-lait spot (HP:0000957)1.67764375
98Cortical dysplasia (HP:0002539)1.67235571
99Squamous cell carcinoma (HP:0002860)1.66814120
100Poikiloderma (HP:0001029)1.66473812

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.55410707
2EIF2AK13.77203281
3EEF2K3.45351160
4PLK43.34225955
5TAOK33.21257211
6CAMK1D2.91143007
7TTK2.76246783
8PDK22.68615248
9NME12.57013666
10CLK12.34000637
11CAMK1G2.23882470
12NTRK32.20609940
13RIPK42.16379875
14KSR22.05408784
15BRSK22.04481113
16LATS11.96524532
17WNK41.91522823
18MAP3K21.77764787
19RAF11.72305523
20FRK1.65477969
21CHEK21.63682896
22CDK121.61636527
23NEK21.60125437
24CDC71.57992082
25WEE11.57210482
26SRPK11.45759709
27PINK11.36604811
28BMPR21.28341978
29MAP3K41.22353338
30ATR1.20680688
31CCNB11.20412026
32ICK1.18707663
33PBK1.18091617
34PKN21.12596692
35ATM1.08856863
36WNK11.05563998
37KSR11.05481207
38TRPM70.99975668
39BMX0.99537548
40RPS6KB20.99480370
41CHEK10.96450625
42MTOR0.94762470
43CDK10.92314488
44STK30.88547505
45NUAK10.88420870
46EIF2AK30.86140425
47EPHA30.84594841
48MKNK10.82991692
49PRKAA10.80409384
50MAP3K70.80003322
51MARK30.75169333
52ALK0.74344546
53PRKAA20.72347008
54CDK20.69833437
55TSSK60.69228177
56TEC0.68640364
57TNIK0.68470097
58MAPK130.67366198
59MAPKAPK50.66442397
60MKNK20.66109598
61SGK10.62523402
62PLK10.60576785
63DYRK30.60038524
64GSK3B0.59434158
65MAP3K80.58211930
66PAK20.57675068
67BRAF0.57537067
68MAPK100.57255944
69RET0.57220199
70CDK40.55798430
71CSNK1E0.55235273
72NEK10.54533195
73BRD40.54147832
74MAP2K10.53800119
75IRAK30.52997739
76JAK20.51877176
77DMPK0.51014869
78PRKDC0.50640252
79BRSK10.50569140
80AURKB0.48955881
81SGK20.47439953
82MAPK140.45400175
83STK40.43289406
84PNCK0.42924522
85AKT10.42812559
86FGFR10.42779583
87CSNK2A20.42588914
88PLK30.41536804
89STK380.41128657
90MAPKAPK30.40087099
91MAP4K20.39155222
92MAPK110.38944728
93MAP3K130.38619675
94PTK60.38379012
95PAK10.38374074
96LATS20.37441123
97YES10.36642451
98TNK20.36416314
99MAPK10.35724176
100FGFR30.35428322

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006704.33558962
2Homologous recombination_Homo sapiens_hsa034404.06795391
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.86351562
4Fanconi anemia pathway_Homo sapiens_hsa034602.77778901
5DNA replication_Homo sapiens_hsa030302.70049187
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.64505652
7Mismatch repair_Homo sapiens_hsa034302.46753385
8RNA transport_Homo sapiens_hsa030132.25034678
9Steroid biosynthesis_Homo sapiens_hsa001002.24962448
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.17753887
11Pyruvate metabolism_Homo sapiens_hsa006202.15744645
12Olfactory transduction_Homo sapiens_hsa047402.08699586
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02024159
14Propanoate metabolism_Homo sapiens_hsa006402.00954401
15Nucleotide excision repair_Homo sapiens_hsa034201.88357513
16Cysteine and methionine metabolism_Homo sapiens_hsa002701.79825321
17Butanoate metabolism_Homo sapiens_hsa006501.76119632
18Cell cycle_Homo sapiens_hsa041101.74897981
19Basal transcription factors_Homo sapiens_hsa030221.69855946
20mRNA surveillance pathway_Homo sapiens_hsa030151.65113992
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64089489
22Fructose and mannose metabolism_Homo sapiens_hsa000511.57579779
23Spliceosome_Homo sapiens_hsa030401.52199607
24Fatty acid biosynthesis_Homo sapiens_hsa000611.50993800
25Lysine degradation_Homo sapiens_hsa003101.50121081
26Selenocompound metabolism_Homo sapiens_hsa004501.48354510
27Non-homologous end-joining_Homo sapiens_hsa034501.46956731
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.38295503
29Biosynthesis of amino acids_Homo sapiens_hsa012301.29942758
30Arginine biosynthesis_Homo sapiens_hsa002201.29839575
31Base excision repair_Homo sapiens_hsa034101.25904608
32Fatty acid metabolism_Homo sapiens_hsa012121.22729639
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15713530
34RNA degradation_Homo sapiens_hsa030181.13067907
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11939048
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10579767
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07263379
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06698291
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04336156
40Acute myeloid leukemia_Homo sapiens_hsa052211.02955708
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02788978
42Carbon metabolism_Homo sapiens_hsa012000.99308448
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97793809
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93617475
45Type II diabetes mellitus_Homo sapiens_hsa049300.92507163
46Chronic myeloid leukemia_Homo sapiens_hsa052200.88215437
47mTOR signaling pathway_Homo sapiens_hsa041500.84188378
48ABC transporters_Homo sapiens_hsa020100.80620410
49RNA polymerase_Homo sapiens_hsa030200.79649839
50Ribosome_Homo sapiens_hsa030100.79488307
51MicroRNAs in cancer_Homo sapiens_hsa052060.72724420
52Pyrimidine metabolism_Homo sapiens_hsa002400.72502821
53Purine metabolism_Homo sapiens_hsa002300.72196984
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71075586
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.70791499
56Arginine and proline metabolism_Homo sapiens_hsa003300.67557445
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.66714229
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66105641
59Thyroid cancer_Homo sapiens_hsa052160.64934846
60Nitrogen metabolism_Homo sapiens_hsa009100.64857721
61Oocyte meiosis_Homo sapiens_hsa041140.63798783
62Prostate cancer_Homo sapiens_hsa052150.62186782
63Retinol metabolism_Homo sapiens_hsa008300.60063424
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58167278
65ErbB signaling pathway_Homo sapiens_hsa040120.56585747
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56399315
67Inositol phosphate metabolism_Homo sapiens_hsa005620.54796151
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54309757
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53120510
70HIF-1 signaling pathway_Homo sapiens_hsa040660.52809255
71Metabolic pathways_Homo sapiens_hsa011000.49709906
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48544894
73AMPK signaling pathway_Homo sapiens_hsa041520.47878858
74Taste transduction_Homo sapiens_hsa047420.45534818
75Insulin signaling pathway_Homo sapiens_hsa049100.45013242
76Glutathione metabolism_Homo sapiens_hsa004800.44745172
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43059835
78Vitamin digestion and absorption_Homo sapiens_hsa049770.41790765
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.41646680
80Non-small cell lung cancer_Homo sapiens_hsa052230.41503134
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40939209
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.38427001
83N-Glycan biosynthesis_Homo sapiens_hsa005100.38215736
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38185860
85Pancreatic cancer_Homo sapiens_hsa052120.35118053
86Thyroid hormone synthesis_Homo sapiens_hsa049180.34739657
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34316095
88VEGF signaling pathway_Homo sapiens_hsa043700.34062228
89Huntingtons disease_Homo sapiens_hsa050160.33458303
90Fat digestion and absorption_Homo sapiens_hsa049750.32437715
91Renal cell carcinoma_Homo sapiens_hsa052110.31001267
92Circadian rhythm_Homo sapiens_hsa047100.30842050
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27738380
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25374626
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24179270
96Glioma_Homo sapiens_hsa052140.22626812
97Viral carcinogenesis_Homo sapiens_hsa052030.22606559
98Mineral absorption_Homo sapiens_hsa049780.22291689
99Choline metabolism in cancer_Homo sapiens_hsa052310.19868599
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.19827600

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