FARP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)3.88444432
2hippo signaling (GO:0035329)3.80511962
3positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.74060855
4layer formation in cerebral cortex (GO:0021819)3.67275484
5negative regulation of catenin import into nucleus (GO:0035414)3.66218158
6regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.64540771
7planar cell polarity pathway involved in neural tube closure (GO:0090179)3.49560001
8neuron projection extension involved in neuron projection guidance (GO:1902284)3.44779517
9axon extension involved in axon guidance (GO:0048846)3.44779517
10growth hormone receptor signaling pathway (GO:0060396)3.41800488
11embryonic retina morphogenesis in camera-type eye (GO:0060059)3.41323267
12polarized epithelial cell differentiation (GO:0030859)3.40149525
13negative regulation of fatty acid transport (GO:2000192)3.35595927
14insulin-like growth factor receptor signaling pathway (GO:0048009)3.34685462
15regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.34638573
16collagen fibril organization (GO:0030199)3.28828883
17regulation of activation of Janus kinase activity (GO:0010533)3.25994844
18regulation of non-canonical Wnt signaling pathway (GO:2000050)3.18837913
19cellular response to growth hormone stimulus (GO:0071378)3.18348303
20bone trabecula formation (GO:0060346)3.18294824
21locomotory exploration behavior (GO:0035641)3.17739346
22protein heterotrimerization (GO:0070208)3.16137077
23G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.12275737
24establishment of nucleus localization (GO:0040023)3.01507247
25cytoskeletal anchoring at plasma membrane (GO:0007016)2.99845170
26plasma membrane repair (GO:0001778)2.97079889
27regulation of hippo signaling (GO:0035330)2.97000756
28sequestering of extracellular ligand from receptor (GO:0035581)2.92628927
29metanephric mesenchyme development (GO:0072075)2.86709501
30negative regulation of chondrocyte differentiation (GO:0032331)2.85849212
31paraxial mesoderm development (GO:0048339)2.84957129
32regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.84233086
33outer ear morphogenesis (GO:0042473)2.83943172
34axon extension (GO:0048675)2.82026070
35intestinal cholesterol absorption (GO:0030299)2.80046341
36protein localization to synapse (GO:0035418)2.77400677
37craniofacial suture morphogenesis (GO:0097094)2.76931872
38collecting duct development (GO:0072044)2.76573290
39regulation of axon extension involved in axon guidance (GO:0048841)2.74638684
40synaptic vesicle docking involved in exocytosis (GO:0016081)2.73779644
41kidney mesenchyme development (GO:0072074)2.72706291
42* dendrite morphogenesis (GO:0048813)2.72699795
43endodermal cell differentiation (GO:0035987)2.72494247
44gastrulation with mouth forming second (GO:0001702)2.69052020
45cell adhesion mediated by integrin (GO:0033627)2.67900956
46adherens junction assembly (GO:0034333)2.66637634
47regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.65861421
48glial cell proliferation (GO:0014009)2.65713859
49positive regulation of axon extension (GO:0045773)2.65626449
50cell migration in hindbrain (GO:0021535)2.64125522
51dermatan sulfate biosynthetic process (GO:0030208)2.63804065
52endocardial cushion development (GO:0003197)2.63716215
53regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.63668293
54camera-type eye morphogenesis (GO:0048593)2.63593298
55Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.62516443
56positive regulation of glycogen biosynthetic process (GO:0045725)2.61799742
57cell communication by electrical coupling (GO:0010644)2.59578669
58cochlea morphogenesis (GO:0090103)2.59006983
59neuron recognition (GO:0008038)2.58070236
60regulation of establishment of planar polarity (GO:0090175)2.57218338
61semaphorin-plexin signaling pathway (GO:0071526)2.55851756
62proximal/distal pattern formation (GO:0009954)2.55165165
63regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.54171056
64protein carboxylation (GO:0018214)2.53748970
65peptidyl-glutamic acid carboxylation (GO:0017187)2.53748970
66axonal fasciculation (GO:0007413)2.52891649
67regulation of catenin import into nucleus (GO:0035412)2.52206433
68cell migration involved in sprouting angiogenesis (GO:0002042)2.51343003
69neurotransmitter-gated ion channel clustering (GO:0072578)2.51337795
70cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.50433447
71midgut development (GO:0007494)2.50127204
72negative regulation of sodium ion transport (GO:0010766)2.49884344
73postsynaptic membrane organization (GO:0001941)2.49113792
74body morphogenesis (GO:0010171)2.49011509
75cerebellar Purkinje cell layer development (GO:0021680)2.46928384
76embryonic foregut morphogenesis (GO:0048617)2.46692029
77regulation of tight junction assembly (GO:2000810)2.46379280
78regulation of axon guidance (GO:1902667)2.45978723
79lung epithelium development (GO:0060428)2.44689289
80stress fiber assembly (GO:0043149)2.44200516
81dendritic spine morphogenesis (GO:0060997)2.44075710
82presynaptic membrane assembly (GO:0097105)2.43602732
83non-canonical Wnt signaling pathway (GO:0035567)2.43225626
84central nervous system projection neuron axonogenesis (GO:0021952)2.42593576
85neuron projection extension (GO:1990138)2.41726900
86establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.41527188
87mesenchymal-epithelial cell signaling (GO:0060638)2.41489641
88protein localization to cell surface (GO:0034394)2.40086131
89regulation of posttranscriptional gene silencing (GO:0060147)2.39325594
90regulation of gene silencing by miRNA (GO:0060964)2.39325594
91regulation of gene silencing by RNA (GO:0060966)2.39325594
92negative regulation of fibrinolysis (GO:0051918)2.38884793
93pyrimidine nucleobase catabolic process (GO:0006208)2.38868063
94synaptic vesicle maturation (GO:0016188)2.38701515
95epithelial cell-cell adhesion (GO:0090136)2.38665997
96positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.38043054
97nephron tubule morphogenesis (GO:0072078)2.37544196
98nephron epithelium morphogenesis (GO:0072088)2.37544196
99negative regulation of axon extension involved in axon guidance (GO:0048843)2.37035146
100exploration behavior (GO:0035640)2.36954396
101negative regulation of cartilage development (GO:0061037)2.36609227
102negative regulation of axon guidance (GO:1902668)2.35968987
103notochord development (GO:0030903)2.35799694
104dermatan sulfate metabolic process (GO:0030205)2.35712603
105vocalization behavior (GO:0071625)2.34923668
106inner ear receptor cell development (GO:0060119)2.34465715
107basement membrane organization (GO:0071711)2.33516846
108alanine transport (GO:0032328)2.33376723
109positive regulation of synapse maturation (GO:0090129)2.32578043
110dorsal/ventral axis specification (GO:0009950)2.32538068
111positive regulation of epithelial to mesenchymal transition (GO:0010718)2.31395014
112positive regulation of dendritic spine morphogenesis (GO:0061003)2.30954677
113positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.30090694
114lens fiber cell development (GO:0070307)2.30052161
115chondrocyte development (GO:0002063)2.29989017
116adherens junction organization (GO:0034332)2.28232510
117skin morphogenesis (GO:0043589)2.28069603
118positive regulation of fibroblast migration (GO:0010763)2.27673308
119spinal cord development (GO:0021510)2.27214476
120regulation of cartilage development (GO:0061035)2.27148396
121regulation of chondrocyte differentiation (GO:0032330)2.26845791
122cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.26606086
123establishment of monopolar cell polarity (GO:0061162)2.26198872
124establishment or maintenance of monopolar cell polarity (GO:0061339)2.26198872
125anatomical structure maturation (GO:0071695)2.25898617
126proline transport (GO:0015824)2.25839716
127lateral sprouting from an epithelium (GO:0060601)2.25456051
128positive regulation of cartilage development (GO:0061036)2.23310913
129regulation of apoptotic cell clearance (GO:2000425)2.23214598
130convergent extension (GO:0060026)2.22253610
131positive regulation of receptor internalization (GO:0002092)2.22167172
132positive regulation of mesenchymal cell proliferation (GO:0002053)2.21586411
133renal tubule morphogenesis (GO:0061333)2.19868053
134sodium ion export (GO:0071436)2.19683319
135regulation of heart morphogenesis (GO:2000826)2.19212830
136positive regulation of dendritic spine development (GO:0060999)2.18979154
137ectodermal placode formation (GO:0060788)2.18683291
138regulation of protein activation cascade (GO:2000257)2.18243341
139positive regulation of smoothened signaling pathway (GO:0045880)2.18088176
140negative chemotaxis (GO:0050919)2.17391341
141negative regulation of embryonic development (GO:0045992)2.17146360
142regulation of complement activation (GO:0030449)2.16992740
143presynaptic membrane organization (GO:0097090)2.16258859
144bone remodeling (GO:0046849)2.15674508
145dopaminergic neuron differentiation (GO:0071542)2.12047857
146limb bud formation (GO:0060174)2.09138475
147nucleobase catabolic process (GO:0046113)2.07051269
148mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.05741427
149regulation of fibrinolysis (GO:0051917)2.05682642
150negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.04990575
151negative regulation of translation, ncRNA-mediated (GO:0040033)2.04990575
152regulation of translation, ncRNA-mediated (GO:0045974)2.04990575
153regulation of plasminogen activation (GO:0010755)2.04821660
154response to growth hormone (GO:0060416)2.04242536
155negative regulation of protein activation cascade (GO:2000258)2.03636155
156positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.03146618
157regulation of short-term neuronal synaptic plasticity (GO:0048172)2.01722587
158intestinal absorption (GO:0050892)2.00812914
159gamma-aminobutyric acid transport (GO:0015812)2.00070788
160peristalsis (GO:0030432)1.99334608
161cell-cell junction maintenance (GO:0045217)1.99133078
162cell migration involved in gastrulation (GO:0042074)1.98833094
163positive regulation of canonical Wnt signaling pathway (GO:0090263)1.97842369
164negative regulation of lipase activity (GO:0060192)1.96181561
165regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)1.95669683

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.16351260
2EZH2_22144423_ChIP-Seq_EOC_Human2.50686454
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.43363052
4WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.29867994
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28238806
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28238806
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20167421
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20117570
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14020983
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.10454194
11EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.03801155
12* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01820706
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99521761
14JARID2_20064375_ChIP-Seq_MESCs_Mouse1.99214715
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97848197
16ZFP281_18757296_ChIP-ChIP_E14_Mouse1.95735903
17EZH2_27304074_Chip-Seq_ESCs_Mouse1.95016462
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94691967
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92850068
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91598539
21* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.88262326
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86706173
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.84252280
24* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83294469
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.78953284
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75886302
27* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75369569
28* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.73279096
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.70446651
30* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.67328600
31ZFP281_27345836_Chip-Seq_ESCs_Mouse1.66546173
32DROSHA_22980978_ChIP-Seq_HELA_Human1.66436509
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.64965000
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.64542218
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64383346
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62612760
37KDM2B_26808549_Chip-Seq_K562_Human1.59742417
38TP53_20018659_ChIP-ChIP_R1E_Mouse1.58756712
39CLOCK_20551151_ChIP-Seq_293T_Human1.56412484
40* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55195263
41* ISL1_27105846_Chip-Seq_CPCs_Mouse1.54316072
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51059101
43* EZH2_27294783_Chip-Seq_ESCs_Mouse1.50753215
44* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50391031
45* FOXA2_19822575_ChIP-Seq_HepG2_Human1.50179627
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.49359864
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.47753953
48RING1B_27294783_Chip-Seq_NPCs_Mouse1.45295185
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44922467
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.44325174
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43708373
52* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.42152837
53AR_21572438_ChIP-Seq_LNCaP_Human1.39629104
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39591087
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39183835
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.38026777
57* RING1B_27294783_Chip-Seq_ESCs_Mouse1.37469637
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34863615
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32243893
60REST_21632747_ChIP-Seq_MESCs_Mouse1.31557033
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31149480
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29916592
63SMAD3_21741376_ChIP-Seq_HESCs_Human1.28229024
64SMAD4_21799915_ChIP-Seq_A2780_Human1.28211095
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27527314
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.23644683
67TP53_16413492_ChIP-PET_HCT116_Human1.23390004
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23316438
69* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23042579
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.21576045
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21166688
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18761732
73* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18574046
74CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18371010
75RNF2_27304074_Chip-Seq_NSC_Mouse1.17781855
76GBX2_23144817_ChIP-Seq_PC3_Human1.17666190
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17374104
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16549732
79AHR_22903824_ChIP-Seq_MCF-7_Human1.16412230
80FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.16171929
81* SMAD3_21741376_ChIP-Seq_EPCs_Human1.16159512
82TP53_18474530_ChIP-ChIP_U2OS_Human1.15605795
83CJUN_26792858_Chip-Seq_BT549_Human1.15059688
84* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13151316
85* BRD4_25478319_ChIP-Seq_HGPS_Human1.12743162
86* AR_19668381_ChIP-Seq_PC3_Human1.11445052
87HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11038753
88* KDM2B_26808549_Chip-Seq_JURKAT_Human1.10506316
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.09416759
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09049116
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08819484
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08337741
93STAT3_23295773_ChIP-Seq_U87_Human1.07572595
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07169320
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06090287
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04472787
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.04216417
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.04061510
99ESR1_21235772_ChIP-Seq_MCF-7_Human1.03720893
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03659659
101NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03295037
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01961714
103P300_19829295_ChIP-Seq_ESCs_Human1.01922865
104OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01580605
105* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01490534
106ZNF274_21170338_ChIP-Seq_K562_Hela1.01237388
107TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00884629
108CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00707524
109TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00699800
110SMAD_19615063_ChIP-ChIP_OVARY_Human1.00391844
111TCF4_18268006_ChIP-ChIP_LS174T_Human0.99334196
112* TP53_23651856_ChIP-Seq_MEFs_Mouse0.99324998
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99266806
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98719076
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98719076
116HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98697727
117RARB_27405468_Chip-Seq_BRAIN_Mouse0.98643779
118RXR_22108803_ChIP-Seq_LS180_Human0.98605562
119PIAS1_25552417_ChIP-Seq_VCAP_Human0.98372756
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.98346263
121ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97965009
122IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97552952
123* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97151756
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96892002
125* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96768567
126PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95610526
127LXR_22292898_ChIP-Seq_THP-1_Human0.95560641
128KDM2B_26808549_Chip-Seq_DND41_Human0.95525987
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94953962
130SMAD3_21741376_ChIP-Seq_ESCs_Human0.94842568
131TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94637037
132ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94469401
133ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93722313
134* RACK7_27058665_Chip-Seq_MCF-7_Human0.93362881
135NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92524823
136KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92429505

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.76145354
2MP0003705_abnormal_hypodermis_morpholog3.69025021
3MP0005623_abnormal_meninges_morphology2.94037951
4MP0010030_abnormal_orbit_morphology2.84876880
5MP0005503_abnormal_tendon_morphology2.55459511
6MP0009780_abnormal_chondrocyte_physiolo2.42246414
7MP0005275_abnormal_skin_tensile2.32471276
8MP0004272_abnormal_basement_membrane2.26992852
9MP0003283_abnormal_digestive_organ2.23045107
10MP0003385_abnormal_body_wall2.21982267
11MP0009384_cardiac_valve_regurgitation2.20055097
12MP0000537_abnormal_urethra_morphology2.18204399
13MP0009053_abnormal_anal_canal2.17110781
14MP0003122_maternal_imprinting2.11295023
15MP0004859_abnormal_synaptic_plasticity2.06323718
16MP0003942_abnormal_urinary_system2.02762326
17MP0003279_aneurysm2.02328466
18MP0000534_abnormal_ureter_morphology1.99476508
19MP0009250_abnormal_appendicular_skeleto1.94286586
20MP0001958_emphysema1.85658929
21MP0004858_abnormal_nervous_system1.84197369
22MP0001299_abnormal_eye_distance/1.78629485
23MP0003115_abnormal_respiratory_system1.73834684
24MP0005257_abnormal_intraocular_pressure1.67131717
25MP0002249_abnormal_larynx_morphology1.64702506
26MP0005508_abnormal_skeleton_morphology1.63099961
27MP0000049_abnormal_middle_ear1.57834466
28MP0000428_abnormal_craniofacial_morphol1.56298609
29MP0003755_abnormal_palate_morphology1.56290735
30MP0002896_abnormal_bone_mineralization1.52006473
31MP0002932_abnormal_joint_morphology1.49943277
32MP0005248_abnormal_Harderian_gland1.49197558
33MP0000733_abnormal_muscle_development1.48262864
34MP0010352_gastrointestinal_tract_polyps1.47893792
35MP0003195_calcinosis1.47758296
36MP0005076_abnormal_cell_differentiation1.46268046
37MP0003091_abnormal_cell_migration1.44123802
38MP0003136_yellow_coat_color1.42860542
39MP0003935_abnormal_craniofacial_develop1.40016862
40MP0002089_abnormal_postnatal_growth/wei1.39518021
41MP0003937_abnormal_limbs/digits/tail_de1.38043118
42MP0004043_abnormal_pH_regulation1.37794420
43MP0003119_abnormal_digestive_system1.34766917
44MP0003123_paternal_imprinting1.34049698
45MP0002116_abnormal_craniofacial_bone1.33861979
46MP0002282_abnormal_trachea_morphology1.33318083
47MP0005187_abnormal_penis_morphology1.33052115
48MP0005409_darkened_coat_color1.32665138
49MP0003890_abnormal_embryonic-extraembry1.32281682
50MP0002234_abnormal_pharynx_morphology1.31881739
51MP0006292_abnormal_olfactory_placode1.31453356
52MP0004233_abnormal_muscle_weight1.29912534
53MP0002233_abnormal_nose_morphology1.29861320
54MP0004133_heterotaxia1.28758749
55MP0003566_abnormal_cell_adhesion1.27279234
56MP0000569_abnormal_digit_pigmentation1.27063366
57MP0001348_abnormal_lacrimal_gland1.26651075
58MP0000778_abnormal_nervous_system1.23753482
59MP0000163_abnormal_cartilage_morphology1.23311393
60MP0010234_abnormal_vibrissa_follicle1.18079831
61MP0003941_abnormal_skin_development1.15345474
62MP0010368_abnormal_lymphatic_system1.14476934
63MP0001849_ear_inflammation1.13300808
64MP0000955_abnormal_spinal_cord1.12540529
65MP0002909_abnormal_adrenal_gland1.12305640
66MP0003938_abnormal_ear_development1.10995333
67MP0002108_abnormal_muscle_morphology1.10001070
68MP0000432_abnormal_head_morphology1.09679014
69MP0005423_abnormal_somatic_nervous1.09069623
70MP0005171_absent_coat_pigmentation1.06714648
71MP0002115_abnormal_skeleton_extremities1.06141427
72MP0001286_abnormal_eye_development1.05698629
73MP0003121_genomic_imprinting1.05197003
74MP0003878_abnormal_ear_physiology1.04168802
75MP0005377_hearing/vestibular/ear_phenot1.04168802
76MP0000566_synostosis1.04021384
77MP0004270_analgesia1.03562574
78MP0000462_abnormal_digestive_system1.03501347
79MP0006054_spinal_hemorrhage1.02325720
80MP0002734_abnormal_mechanical_nocicepti1.01078352
81MP0005367_renal/urinary_system_phenotyp1.00168284
82MP0000516_abnormal_urinary_system1.00168284
83MP0002109_abnormal_limb_morphology1.00049606
84MP0002557_abnormal_social/conspecific_i0.99725079
85MP0002295_abnormal_pulmonary_circulatio0.99017852
86MP0003861_abnormal_nervous_system0.96432866
87MP0000762_abnormal_tongue_morphology0.96419095
88MP0002697_abnormal_eye_size0.96037968
89MP0001984_abnormal_olfaction0.96020107
90MP0001293_anophthalmia0.96018485
91MP0001177_atelectasis0.95988883
92MP0002735_abnormal_chemical_nociception0.93357735
93MP0003635_abnormal_synaptic_transmissio0.92264137
94MP0004134_abnormal_chest_morphology0.90602262
95MP0001666_abnormal_nutrient_absorption0.88360631
96MP0003880_abnormal_central_pattern0.88237883
97MP0002168_other_aberrant_phenotype0.87800958
98MP0002653_abnormal_ependyma_morphology0.87528473
99MP0005394_taste/olfaction_phenotype0.87302909
100MP0005499_abnormal_olfactory_system0.87302909
101MP0002111_abnormal_tail_morphology0.87027721
102MP0002152_abnormal_brain_morphology0.86156438
103MP0005023_abnormal_wound_healing0.85988647
104MP0002114_abnormal_axial_skeleton0.85921492
105MP0000579_abnormal_nail_morphology0.85317449
106MP0003045_fibrosis0.83863171
107MP0000013_abnormal_adipose_tissue0.83457871
108MP0000767_abnormal_smooth_muscle0.82999468
109MP0004197_abnormal_fetal_growth/weight/0.82852478
110MP0004885_abnormal_endolymph0.82045165
111MP0002938_white_spotting0.82001742
112MP0000678_abnormal_parathyroid_gland0.81785680
113MP0002882_abnormal_neuron_morphology0.81221821
114MP0002925_abnormal_cardiovascular_devel0.80684059
115MP0001340_abnormal_eyelid_morphology0.80567331
116MP0002752_abnormal_somatic_nervous0.80316381
117MP0002139_abnormal_hepatobiliary_system0.80083203
118MP0002081_perinatal_lethality0.79633686
119MP0000003_abnormal_adipose_tissue0.79629406
120MP0005551_abnormal_eye_electrophysiolog0.79291301
121MP0002572_abnormal_emotion/affect_behav0.78117233
122MP0002113_abnormal_skeleton_development0.77988197
123MP0003567_abnormal_fetal_cardiomyocyte0.77818445
124MP0002184_abnormal_innervation0.77752403
125MP0002084_abnormal_developmental_patter0.76639511
126MP0000538_abnormal_urinary_bladder0.76276425
127MP0002177_abnormal_outer_ear0.76256034
128MP0000631_abnormal_neuroendocrine_gland0.76212259
129MP0003879_abnormal_hair_cell0.76187955
130MP0000026_abnormal_inner_ear0.76180686
131MP0002092_abnormal_eye_morphology0.76130858
132MP0001756_abnormal_urination0.76104752
133MP0001486_abnormal_startle_reflex0.75975105
134MP0002063_abnormal_learning/memory/cond0.73403854
135MP0001270_distended_abdomen0.72684241
136MP0002060_abnormal_skin_morphology0.72171444
137MP0008961_abnormal_basal_metabolism0.70909963

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.93736531
2Shallow orbits (HP:0000586)4.60661952
3Premature rupture of membranes (HP:0001788)4.29933878
4Short 4th metacarpal (HP:0010044)3.15771944
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.15771944
6Bladder diverticulum (HP:0000015)2.97800580
7Broad metatarsal (HP:0001783)2.94260622
8Deep venous thrombosis (HP:0002625)2.91126067
9Atrophic scars (HP:0001075)2.90065896
10Neonatal short-limb short stature (HP:0008921)2.86877741
11Ankle contracture (HP:0006466)2.86567127
12Cerebral aneurysm (HP:0004944)2.74836468
13Hepatoblastoma (HP:0002884)2.72927407
14Renal duplication (HP:0000075)2.68652882
15Abnormality of the 4th metacarpal (HP:0010012)2.67477582
16Aortic dissection (HP:0002647)2.65408818
17Abnormality of dentin (HP:0010299)2.63389573
18Mitral valve prolapse (HP:0001634)2.60816903
19Overgrowth (HP:0001548)2.60786865
20Genu recurvatum (HP:0002816)2.58441242
21Dilatation of the ascending aorta (HP:0005111)2.58193433
22Deviation of the hallux (HP:0010051)2.50721632
23Coronal craniosynostosis (HP:0004440)2.46895848
24Vertebral arch anomaly (HP:0008438)2.46108605
25Bowel diverticulosis (HP:0005222)2.42527716
26Buphthalmos (HP:0000557)2.41253261
27Hallux valgus (HP:0001822)2.39818216
28Peritonitis (HP:0002586)2.30761182
29Bronchomalacia (HP:0002780)2.29757868
30Aortic aneurysm (HP:0004942)2.29678379
31Turricephaly (HP:0000262)2.29434109
32Cervical subluxation (HP:0003308)2.28957768
33Aplasia involving bones of the extremities (HP:0009825)2.27677018
34Aplasia involving bones of the upper limbs (HP:0009823)2.27677018
35Aplasia of the phalanges of the hand (HP:0009802)2.27677018
36Fragile skin (HP:0001030)2.25242301
37Wrist flexion contracture (HP:0001239)2.19293597
38Soft skin (HP:0000977)2.16836014
39Genetic anticipation (HP:0003743)2.15034510
40Hyperextensible skin (HP:0000974)2.13659969
41Wide anterior fontanel (HP:0000260)2.13477612
42Megalencephaly (HP:0001355)2.12598645
43Subacute progressive viral hepatitis (HP:0006572)2.09390438
44Mitral stenosis (HP:0001718)2.08480133
45Asymmetry of the thorax (HP:0001555)2.07424394
46Blue sclerae (HP:0000592)2.07269758
47Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.07144982
48Lymphangioma (HP:0100764)2.06955461
49Vascular tortuosity (HP:0004948)2.04658008
50Broad thumb (HP:0011304)2.00277609
51Broad long bones (HP:0005622)1.99579660
52Broad palm (HP:0001169)1.99139221
53Flat acetabular roof (HP:0003180)1.98988900
54Wormian bones (HP:0002645)1.97133868
55Hyperacusis (HP:0010780)1.96899933
56Aneurysm (HP:0002617)1.94322005
57Hyperventilation (HP:0002883)1.93750775
58Broad ribs (HP:0000885)1.93345309
59Congenital glaucoma (HP:0001087)1.93183533
60Mesomelia (HP:0003027)1.92346629
61Vitreoretinal degeneration (HP:0000655)1.92059153
62Shawl scrotum (HP:0000049)1.91992754
63Morphological abnormality of the middle ear (HP:0008609)1.91704304
64Macroorchidism (HP:0000053)1.90285572
65Spinal rigidity (HP:0003306)1.88928436
66Renovascular hypertension (HP:0100817)1.87581552
67Obstructive sleep apnea (HP:0002870)1.86912404
68Arterial tortuosity (HP:0005116)1.86633556
69Neoplasm of the heart (HP:0100544)1.85893577
70Camptodactyly of toe (HP:0001836)1.83293525
71Back pain (HP:0003418)1.83046293
72Mildly elevated creatine phosphokinase (HP:0008180)1.82733317
73Enlarged penis (HP:0000040)1.82662848
74Abnormality of the pubic bones (HP:0003172)1.82281837
75Ankyloglossia (HP:0010296)1.79060934
76Abnormality of the distal phalanx of the thumb (HP:0009617)1.78632964
77Fibular aplasia (HP:0002990)1.78544567
78Broad phalanx (HP:0006009)1.77638697
79Prolonged partial thromboplastin time (HP:0003645)1.76914669
80Broad alveolar ridges (HP:0000187)1.75997640
81Abnormality of the ischium (HP:0003174)1.75109539
82Alacrima (HP:0000522)1.75028011
83Abnormality of the nasal septum (HP:0000419)1.74491693
84Choanal stenosis (HP:0000452)1.74295346
85Cutaneous finger syndactyly (HP:0010554)1.73988356
86Midline defect of the nose (HP:0004122)1.73947542
87Exostoses (HP:0100777)1.72980336
88Thin bony cortex (HP:0002753)1.72678034
89Abnormality of carpal bone ossification (HP:0006257)1.72631693
90Exotropia (HP:0000577)1.71631572
91Anophthalmia (HP:0000528)1.71152200
92Long toe (HP:0010511)1.71036524
93Limited hip movement (HP:0008800)1.70735064
94Broad finger (HP:0001500)1.70396635
95Follicular hyperkeratosis (HP:0007502)1.69202261
96Bell-shaped thorax (HP:0001591)1.69149150
97Joint laxity (HP:0001388)1.68545542
98Elfin facies (HP:0004428)1.68236627
99Broad phalanges of the hand (HP:0009768)1.68075479
100Flat cornea (HP:0007720)1.67334826
101Ulnar bowing (HP:0003031)1.66074910
102Broad toe (HP:0001837)1.65641811
103Preaxial foot polydactyly (HP:0001841)1.65640795
104Infantile muscular hypotonia (HP:0008947)1.65288535
105Absent epiphyses (HP:0010577)1.64752322
106Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.64752322
107Hypoplastic ischia (HP:0003175)1.63740336
108Mitral regurgitation (HP:0001653)1.62649944
109Bilateral microphthalmos (HP:0007633)1.61819616
110Arnold-Chiari malformation (HP:0002308)1.61508656
111Hypoplasia of the capital femoral epiphysis (HP:0003090)1.59472529
112Trigonocephaly (HP:0000243)1.59098091
113Biconcave vertebral bodies (HP:0004586)1.58398518
114Hypoventilation (HP:0002791)1.58365379
115Blue irides (HP:0000635)1.57897718
116Type 1 muscle fiber predominance (HP:0003803)1.57774956
117Laryngomalacia (HP:0001601)1.56610224
118Cutaneous syndactyly (HP:0012725)1.56179346
119Distal upper limb amyotrophy (HP:0007149)1.55488299
120Upper limb amyotrophy (HP:0009129)1.55488299
121Complement deficiency (HP:0004431)1.55294905
122Abnormality of the aortic arch (HP:0012303)1.54857251
123Abnormality of oral frenula (HP:0000190)1.54656766
124Mild short stature (HP:0003502)1.54085226
125Tibial bowing (HP:0002982)1.53978562
126Abnormality of the acetabulum (HP:0003170)1.53843714
127Radial bowing (HP:0002986)1.53609158
128Insomnia (HP:0100785)1.53605457
129Microglossia (HP:0000171)1.53048257
130Disproportionate tall stature (HP:0001519)1.52223654
131Spinal cord compression (HP:0002176)1.51963078
132Pointed chin (HP:0000307)1.51961646
133Bowing of the arm (HP:0006488)1.50863397
134Bowed forearm bones (HP:0003956)1.50863397
135Abnormal ossification of hand bones (HP:0005921)1.50291679
136Severe Myopia (HP:0011003)1.50288474
137Abnormal hand bone ossification (HP:0010660)1.50149878
138Premature skin wrinkling (HP:0100678)1.49724471
139Epiphyseal dysplasia (HP:0002656)1.49668612
140Drooling (HP:0002307)1.49665044
141Potter facies (HP:0002009)1.47726336
142Facial shape deformation (HP:0011334)1.47726336
143Heterotopia (HP:0002282)1.44489394
144Focal seizures (HP:0007359)1.43068475
145Abnormality of the middle phalanges of the toes (HP:0010183)1.42629820
146Mixed hearing impairment (HP:0000410)1.42592207
147Anal stenosis (HP:0002025)1.42224563
148Bicornuate uterus (HP:0000813)1.41957451
149Hypobetalipoproteinemia (HP:0003563)1.41889162
150Flared iliac wings (HP:0002869)1.41863300
151Severe short stature (HP:0003510)1.41496603
152Bifid tongue (HP:0010297)1.39457650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.74213182
2LATS23.72744840
3DDR23.59331786
4LATS13.25418203
5CASK3.05195380
6MARK13.01281037
7AKT32.93872216
8PDGFRA2.89388372
9RIPK12.42034649
10PRKD32.41709494
11WNK42.21476869
12PKN22.15462746
13WNK32.11551293
14EPHB22.07440887
15SIK11.98578574
16TTN1.90449090
17PAK31.77827602
18SGK2231.70941443
19SGK4941.70941443
20FGFR41.68399638
21PTK21.65531126
22PAK61.62327963
23MAP3K91.58602788
24SGK21.53371971
25PNCK1.44497424
26EEF2K1.43067217
27TYRO31.42441285
28BMX1.42125948
29TAOK11.34802898
30FER1.33694295
31NTRK21.33496268
32PTK61.33488783
33NTRK11.29679326
34STK38L1.28436358
35MINK11.24310295
36PAK21.24100656
37PHKG21.23661031
38PHKG11.23661031
39FGFR11.20878568
40CAMK1G1.19937072
41NTRK31.19872767
42DMPK1.18114035
43OXSR11.17115293
44STK391.16935578
45KSR11.16907653
46MAP3K101.14758974
47LMTK21.11919522
48PDGFRB1.11676420
49FGFR31.10124452
50CAMKK11.10097739
51STK381.09464941
52ICK1.08529142
53MTOR1.08383574
54ERBB31.06323160
55EPHA41.03631042
56KSR21.02534778
57MAPK151.01098429
58EPHA20.99226116
59WNK10.98202357
60RET0.97664258
61MAP3K40.97355843
62MYLK0.96678092
63CDK120.94809770
64ERBB20.94268477
65ROCK10.88072676
66FGFR20.86609820
67INSRR0.85980830
68CDC42BPA0.85744474
69ILK0.85634006
70CAMK1D0.84337756
71PRKCH0.80764204
72ALK0.80303424
73DAPK20.78821673
74BCR0.78675823
75MARK20.76873438
76ERN10.76199003
77STK30.73682899
78PRKD20.73021252
79DYRK1B0.72594552
80MAP4K20.72458210
81MAPK130.71032990
82DYRK20.68461956
83CAMK40.66063929
84MAP2K10.65830730
85PAK40.65706766
86TNIK0.64712521
87MAP3K20.64016437
88PRKAA10.63500930
89PRKAA20.63291237
90PLK20.61623180
91MET0.61385164
92SIK20.61312149
93FRK0.61109918
94MAP2K70.60231751
95CDK150.59282175
96BRD40.59268650
97SGK10.59039362
98BMPR1B0.57663602
99CDK140.57091612
100CDK50.56432833
101MAP2K40.56010898
102PTK2B0.55680723
103CDK180.55262381
104NEK20.55183573
105CAMK10.53871676
106LIMK10.51646812
107SCYL20.49312627
108ERBB40.48650871
109CDK11A0.48441956
110MAP3K70.46954577
111ROCK20.46954170
112CDK60.46679035
113PRKCE0.46481681
114SGK30.46062284
115CSNK1E0.45955578
116STK110.45904823
117PRKD10.44955769
118PRKCZ0.44491254
119CSNK1G20.43188907
120RPS6KA20.41954697
121CSNK1A1L0.40526448
122PRKCI0.40142827
123EPHA30.39962022
124UHMK10.39238132
125SRC0.38800353
126LRRK20.38794185
127PIK3CA0.38521782
128NEK10.37773535
129ADRBK10.37494667
130HIPK20.37061205
131MAP3K60.36941601
132RPS6KA30.36866705
133PRKCG0.36457495
134DYRK1A0.35875088
135GSK3B0.34565443

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046102.13459150
2Basal cell carcinoma_Homo sapiens_hsa052172.13192669
3Hippo signaling pathway_Homo sapiens_hsa043902.04941134
4ECM-receptor interaction_Homo sapiens_hsa045122.03681501
5Nitrogen metabolism_Homo sapiens_hsa009101.96974836
6Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.90423291
7Focal adhesion_Homo sapiens_hsa045101.87817628
8Adherens junction_Homo sapiens_hsa045201.83518472
9Hedgehog signaling pathway_Homo sapiens_hsa043401.82424732
10Axon guidance_Homo sapiens_hsa043601.72583793
11Proteoglycans in cancer_Homo sapiens_hsa052051.71910248
12Bladder cancer_Homo sapiens_hsa052191.66566601
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.66122215
14Glioma_Homo sapiens_hsa052141.57026897
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52899600
16Endometrial cancer_Homo sapiens_hsa052131.49994485
17Melanogenesis_Homo sapiens_hsa049161.48443310
18Dilated cardiomyopathy_Homo sapiens_hsa054141.42671868
19Gap junction_Homo sapiens_hsa045401.39831415
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37542455
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.36663238
22Wnt signaling pathway_Homo sapiens_hsa043101.33293187
23Estrogen signaling pathway_Homo sapiens_hsa049151.29474816
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.28501286
25Protein digestion and absorption_Homo sapiens_hsa049741.27322087
26Insulin secretion_Homo sapiens_hsa049111.26121084
27Tight junction_Homo sapiens_hsa045301.26050901
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25264250
29MicroRNAs in cancer_Homo sapiens_hsa052061.23902447
30Histidine metabolism_Homo sapiens_hsa003401.22767895
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21984808
32GnRH signaling pathway_Homo sapiens_hsa049121.21065127
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20787829
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20636351
35TGF-beta signaling pathway_Homo sapiens_hsa043501.20246851
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.20075873
37Colorectal cancer_Homo sapiens_hsa052101.16190311
38ErbB signaling pathway_Homo sapiens_hsa040121.15410885
39Circadian entrainment_Homo sapiens_hsa047131.14772425
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.14504195
41Chronic myeloid leukemia_Homo sapiens_hsa052201.14274706
42Long-term potentiation_Homo sapiens_hsa047201.13954867
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13721381
44mTOR signaling pathway_Homo sapiens_hsa041501.13274039
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12899965
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12642523
47ABC transporters_Homo sapiens_hsa020101.11343998
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10624246
49Amoebiasis_Homo sapiens_hsa051461.09503067
50Rap1 signaling pathway_Homo sapiens_hsa040151.06218882
51Gastric acid secretion_Homo sapiens_hsa049711.03821594
52Cocaine addiction_Homo sapiens_hsa050301.03787774
53Renal cell carcinoma_Homo sapiens_hsa052111.03062802
54Caffeine metabolism_Homo sapiens_hsa002321.02708415
55Small cell lung cancer_Homo sapiens_hsa052221.01585964
56Glutamatergic synapse_Homo sapiens_hsa047241.01449547
57Dorso-ventral axis formation_Homo sapiens_hsa043201.00685239
58Dopaminergic synapse_Homo sapiens_hsa047280.98742950
59Cholinergic synapse_Homo sapiens_hsa047250.98551829
60Melanoma_Homo sapiens_hsa052180.98482974
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98220729
62Salivary secretion_Homo sapiens_hsa049700.97136327
63Amphetamine addiction_Homo sapiens_hsa050310.97071974
64Pancreatic cancer_Homo sapiens_hsa052120.95086021
65Steroid biosynthesis_Homo sapiens_hsa001000.93970482
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93698374
67Taste transduction_Homo sapiens_hsa047420.91839758
68GABAergic synapse_Homo sapiens_hsa047270.91677423
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.91504492
70Oxytocin signaling pathway_Homo sapiens_hsa049210.89921767
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88624176
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.88445258
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87797886
74Type II diabetes mellitus_Homo sapiens_hsa049300.86972494
75Bile secretion_Homo sapiens_hsa049760.86622654
76Thyroid hormone synthesis_Homo sapiens_hsa049180.84904716
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.84585638
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84567260
79Long-term depression_Homo sapiens_hsa047300.83814245
80Nicotine addiction_Homo sapiens_hsa050330.83369353
81Butanoate metabolism_Homo sapiens_hsa006500.83236085
82Lysine degradation_Homo sapiens_hsa003100.82744788
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.82716469
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82621847
85Prostate cancer_Homo sapiens_hsa052150.82102514
86Fat digestion and absorption_Homo sapiens_hsa049750.81758332
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81438462
88Non-small cell lung cancer_Homo sapiens_hsa052230.81080221
89Renin secretion_Homo sapiens_hsa049240.78845715
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.78797595
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78783941
92Insulin signaling pathway_Homo sapiens_hsa049100.78427520
93Fatty acid biosynthesis_Homo sapiens_hsa000610.77183568
94Pathways in cancer_Homo sapiens_hsa052000.76570546
95Ovarian steroidogenesis_Homo sapiens_hsa049130.75722395
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.75619794
97cAMP signaling pathway_Homo sapiens_hsa040240.75405635
98Glucagon signaling pathway_Homo sapiens_hsa049220.75219286
99Synaptic vesicle cycle_Homo sapiens_hsa047210.74758264
100VEGF signaling pathway_Homo sapiens_hsa043700.74117160
101PPAR signaling pathway_Homo sapiens_hsa033200.73205715
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71627708
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70376846
104Choline metabolism in cancer_Homo sapiens_hsa052310.69808587
105Circadian rhythm_Homo sapiens_hsa047100.69661077
106AMPK signaling pathway_Homo sapiens_hsa041520.69582137
107Notch signaling pathway_Homo sapiens_hsa043300.69445716
108Viral myocarditis_Homo sapiens_hsa054160.69204405
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69151430
110Olfactory transduction_Homo sapiens_hsa047400.68036124
111Insulin resistance_Homo sapiens_hsa049310.66524746
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.65551007
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64409787
114Fatty acid degradation_Homo sapiens_hsa000710.64293655
115Calcium signaling pathway_Homo sapiens_hsa040200.63748647
116Retinol metabolism_Homo sapiens_hsa008300.63557088
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.62980722
118Vitamin B6 metabolism_Homo sapiens_hsa007500.62711477
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62300475
120Oocyte meiosis_Homo sapiens_hsa041140.61873582
121Arginine biosynthesis_Homo sapiens_hsa002200.61040717
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60813091
123MAPK signaling pathway_Homo sapiens_hsa040100.60522341
124Ras signaling pathway_Homo sapiens_hsa040140.59633829
125Morphine addiction_Homo sapiens_hsa050320.58829856
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57976376
127Serotonergic synapse_Homo sapiens_hsa047260.57074510
128Phototransduction_Homo sapiens_hsa047440.56211448
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54286244

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