FARP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.21636216
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.21636216
3L-phenylalanine metabolic process (GO:0006558)5.90650301
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.90650301
5aromatic amino acid family catabolic process (GO:0009074)5.42930529
6melanin biosynthetic process (GO:0042438)5.38032753
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.37608659
8melanin metabolic process (GO:0006582)5.06957563
9alpha-linolenic acid metabolic process (GO:0036109)5.01944094
10bile acid biosynthetic process (GO:0006699)4.90609757
11kynurenine metabolic process (GO:0070189)4.79149042
12tryptophan catabolic process (GO:0006569)4.75022940
13indole-containing compound catabolic process (GO:0042436)4.75022940
14indolalkylamine catabolic process (GO:0046218)4.75022940
15negative regulation of fibrinolysis (GO:0051918)4.73743688
16urea metabolic process (GO:0019627)4.71084542
17urea cycle (GO:0000050)4.71084542
18glyoxylate metabolic process (GO:0046487)4.70071561
19protein carboxylation (GO:0018214)4.64394972
20peptidyl-glutamic acid carboxylation (GO:0017187)4.64394972
21cysteine metabolic process (GO:0006534)4.57159469
22sulfur amino acid catabolic process (GO:0000098)4.56481562
23regulation of fibrinolysis (GO:0051917)4.55484545
24high-density lipoprotein particle remodeling (GO:0034375)4.55116698
25regulation of protein activation cascade (GO:2000257)4.48918044
26tryptophan metabolic process (GO:0006568)4.47267561
27nuclear pore complex assembly (GO:0051292)4.42280833
28desmosome organization (GO:0002934)4.42238763
29homocysteine metabolic process (GO:0050667)4.39063307
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.29835231
31nitrogen cycle metabolic process (GO:0071941)4.27743759
32bile acid metabolic process (GO:0008206)4.27322804
33regulation of complement activation (GO:0030449)4.24827384
34serine family amino acid catabolic process (GO:0009071)4.20820732
35complement activation, alternative pathway (GO:0006957)4.20553952
36regulation of triglyceride catabolic process (GO:0010896)4.19667216
37reverse cholesterol transport (GO:0043691)4.19631713
38regulation of cholesterol homeostasis (GO:2000188)4.14266944
39amino-acid betaine metabolic process (GO:0006577)4.14110858
40regulation of bile acid biosynthetic process (GO:0070857)4.10594194
41secondary metabolite biosynthetic process (GO:0044550)4.06949782
42lysine metabolic process (GO:0006553)4.05834691
43lysine catabolic process (GO:0006554)4.05834691
44triglyceride homeostasis (GO:0070328)4.04929866
45acylglycerol homeostasis (GO:0055090)4.04929866
46positive regulation of fatty acid beta-oxidation (GO:0032000)3.99423350
47plasma lipoprotein particle remodeling (GO:0034369)3.95767012
48protein-lipid complex remodeling (GO:0034368)3.95767012
49macromolecular complex remodeling (GO:0034367)3.95767012
50cellular glucuronidation (GO:0052695)3.93740537
51plasma lipoprotein particle clearance (GO:0034381)3.93345711
52aromatic amino acid family metabolic process (GO:0009072)3.91273175
53tyrosine metabolic process (GO:0006570)3.89202117
54regulation of cholesterol esterification (GO:0010872)3.87710475
55cellular ketone body metabolic process (GO:0046950)3.83517548
56intestinal cholesterol absorption (GO:0030299)3.81243393
57bile acid and bile salt transport (GO:0015721)3.80455521
58alpha-amino acid catabolic process (GO:1901606)3.79738631
59negative regulation of cholesterol transport (GO:0032375)3.79708902
60negative regulation of sterol transport (GO:0032372)3.79708902
61phospholipid efflux (GO:0033700)3.79391228
62coenzyme catabolic process (GO:0009109)3.72912989
63nuclear pore organization (GO:0006999)3.72118119
64cellular modified amino acid catabolic process (GO:0042219)3.68458860
65cholesterol efflux (GO:0033344)3.60420561
66glutamate metabolic process (GO:0006536)3.59755346
67fibrinolysis (GO:0042730)3.59341773
68phospholipid homeostasis (GO:0055091)3.58439706
69pore complex assembly (GO:0046931)3.57589638
70positive regulation of lipid catabolic process (GO:0050996)3.57131773
71cellular amino acid catabolic process (GO:0009063)3.57059222
72acetyl-CoA metabolic process (GO:0006084)3.53988213
73short-chain fatty acid metabolic process (GO:0046459)3.51108777
74serine family amino acid metabolic process (GO:0009069)3.49523876
75glycine metabolic process (GO:0006544)3.49234916
76cholesterol homeostasis (GO:0042632)3.47857695
77plasma lipoprotein particle assembly (GO:0034377)3.47008966
78serine family amino acid biosynthetic process (GO:0009070)3.44477387
79drug catabolic process (GO:0042737)3.43745061
80dicarboxylic acid biosynthetic process (GO:0043650)3.43660884
81sterol homeostasis (GO:0055092)3.43041517
82ethanol oxidation (GO:0006069)3.39929360
83uronic acid metabolic process (GO:0006063)3.39679947
84glucuronate metabolic process (GO:0019585)3.39679947
85fatty acid beta-oxidation (GO:0006635)3.37159705
86positive regulation of fatty acid oxidation (GO:0046321)3.36556254
87epoxygenase P450 pathway (GO:0019373)3.35684245
88hemidesmosome assembly (GO:0031581)3.35304647
89very-low-density lipoprotein particle assembly (GO:0034379)3.34992690
90heme transport (GO:0015886)3.34593301
91ketone body metabolic process (GO:1902224)3.34283311
92lipoprotein metabolic process (GO:0042157)3.34174039
93negative regulation of protein activation cascade (GO:2000258)3.33144843
94positive regulation of lipoprotein lipase activity (GO:0051006)3.31962673
95positive regulation of triglyceride lipase activity (GO:0061365)3.31962673
96aspartate family amino acid catabolic process (GO:0009068)3.30892574
97protein-lipid complex assembly (GO:0065005)3.28500382
98fatty acid oxidation (GO:0019395)3.27922407
99indolalkylamine metabolic process (GO:0006586)3.26394175
100regulation of cholesterol metabolic process (GO:0090181)3.26285304
101carboxylic acid catabolic process (GO:0046395)3.23449438
102organic acid catabolic process (GO:0016054)3.23449438
103lipid oxidation (GO:0034440)3.23351585
104regulation of plasminogen activation (GO:0010755)3.22520894
105arginine metabolic process (GO:0006525)3.22024281
106fatty acid catabolic process (GO:0009062)3.21783020
107regulation of fatty acid beta-oxidation (GO:0031998)3.21609783
108monocarboxylic acid catabolic process (GO:0072329)3.19776693
109insulin-like growth factor receptor signaling pathway (GO:0048009)3.18268720
110regulation of NFAT protein import into nucleus (GO:0051532)3.17433806
111cytoskeletal anchoring at plasma membrane (GO:0007016)3.13120335
112regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.10069564
113chromosome condensation (GO:0030261)3.07598823
114negative regulation of fatty acid transport (GO:2000192)3.06075019
115basement membrane organization (GO:0071711)3.00936266
116actin filament depolymerization (GO:0030042)2.95087961
117regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.90104936
118COPII vesicle coating (GO:0048208)2.84842795
119DNA packaging (GO:0006323)2.83272047
120mitotic G1 DNA damage checkpoint (GO:0031571)2.81908284
121regulation of RNA export from nucleus (GO:0046831)2.81510106
122histone H3-K36 demethylation (GO:0070544)2.76868254
123positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.75911756
124melanocyte differentiation (GO:0030318)2.67283443
125cell-substrate junction assembly (GO:0007044)2.65937829
126regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.64641311
127regulation of nucleobase-containing compound transport (GO:0032239)2.60542010
128negative regulation of keratinocyte proliferation (GO:0010839)2.58112080
129pigment cell differentiation (GO:0050931)2.58005066
130cytoplasmic mRNA processing body assembly (GO:0033962)2.57464859
131G1 DNA damage checkpoint (GO:0044783)2.57278211
132regulation of water loss via skin (GO:0033561)2.56800997
133sexual reproduction (GO:0019953)2.56765593
134skin morphogenesis (GO:0043589)2.53837909
135dermatan sulfate biosynthetic process (GO:0030208)2.52803710
136* semaphorin-plexin signaling pathway (GO:0071526)2.51758526
137endocardial cushion development (GO:0003197)2.51490003
138regulation of glucose import in response to insulin stimulus (GO:2001273)2.49848759
139COPI coating of Golgi vesicle (GO:0048205)2.49474842
140Golgi transport vesicle coating (GO:0048200)2.49474842
141intestinal epithelial cell development (GO:0060576)2.49254216
142cell adhesion mediated by integrin (GO:0033627)2.47925267
143embryonic foregut morphogenesis (GO:0048617)2.46344798
144mitotic G1/S transition checkpoint (GO:0044819)2.44803944
145peptidyl-lysine dimethylation (GO:0018027)2.44378805
146histone H3-K9 demethylation (GO:0033169)2.44225029
147mitotic sister chromatid cohesion (GO:0007064)2.42461850
148UDP-N-acetylglucosamine metabolic process (GO:0006047)2.41970253
149dermatan sulfate metabolic process (GO:0030205)2.40893778
150endosome to melanosome transport (GO:0035646)2.40300099
151endosome to pigment granule transport (GO:0043485)2.40300099
152intestinal absorption (GO:0050892)2.40172405
153smooth muscle tissue development (GO:0048745)2.35980112
154vitamin transmembrane transport (GO:0035461)2.34190367
155hair cell differentiation (GO:0035315)2.31751851
156lipid translocation (GO:0034204)2.29971414
157phospholipid translocation (GO:0045332)2.29971414
158embryonic eye morphogenesis (GO:0048048)2.28651063
159embryonic camera-type eye morphogenesis (GO:0048596)2.28024091
160chondrocyte proliferation (GO:0035988)2.27853494
161adherens junction assembly (GO:0034333)2.27823898
162membrane protein ectodomain proteolysis (GO:0006509)2.26601150
163establishment of skin barrier (GO:0061436)2.26266798
164embryonic skeletal joint morphogenesis (GO:0060272)2.24891911
165establishment of spindle localization (GO:0051293)2.24815070
166paraxial mesoderm development (GO:0048339)2.24295236
167Golgi to endosome transport (GO:0006895)2.20715350
168genitalia morphogenesis (GO:0035112)2.20272036
169negative regulation of catenin import into nucleus (GO:0035414)2.19359911
170epithelial cell-cell adhesion (GO:0090136)2.19224504
171branching involved in mammary gland duct morphogenesis (GO:0060444)2.18979610
172striated muscle atrophy (GO:0014891)2.18709416
173collagen fibril organization (GO:0030199)2.18498514
174bundle of His cell to Purkinje myocyte communication (GO:0086069)2.17275386
175protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.17107876
176negative regulation of cell size (GO:0045792)2.16565690
177receptor recycling (GO:0001881)2.16339664
178focal adhesion assembly (GO:0048041)2.14881274
179cell-substrate adherens junction assembly (GO:0007045)2.14881274
180establishment of spindle orientation (GO:0051294)2.14318408
181protein localization to endosome (GO:0036010)2.12418262
182glomerular visceral epithelial cell development (GO:0072015)2.12403664
183gap junction assembly (GO:0016264)2.11819353
184mitotic chromosome condensation (GO:0007076)2.11224394
185eye morphogenesis (GO:0048592)2.10710580
186mitotic cytokinesis (GO:0000281)2.10446170
187anterior/posterior axis specification, embryo (GO:0008595)2.10341316
188negative regulation of Rho protein signal transduction (GO:0035024)2.10133727
189renal filtration (GO:0097205)2.10025507
190negative regulation of chondrocyte differentiation (GO:0032331)2.09936636
191centrosome duplication (GO:0051298)2.07828683
192histone lysine demethylation (GO:0070076)2.06224316
193pericardium development (GO:0060039)2.05942016
194sperm capacitation (GO:0048240)2.05656577
195hippo signaling (GO:0035329)2.04003512

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.94093156
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.42725362
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.46039561
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.29632567
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.85876392
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.93030388
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.88359582
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.49094483
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.04801831
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.58552456
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.31956349
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.16864526
13E2F7_22180533_ChIP-Seq_HELA_Human2.16318667
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.03381958
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.00511936
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.96692754
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93154267
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.91616338
19CLOCK_20551151_ChIP-Seq_293T_Human1.91419125
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85240815
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.83424331
22* FOXA2_19822575_ChIP-Seq_HepG2_Human1.79379115
23NFIB_24661679_ChIP-Seq_LUNG_Mouse1.77894583
24KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.77047123
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.76490522
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.76396780
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71611058
28UBF1/2_26484160_Chip-Seq_HMECs_Human1.70279859
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.66916261
30TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.65829683
31TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.62905288
32ARNT_22903824_ChIP-Seq_MCF-7_Human1.57991664
33* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54174739
34RUNX1_27514584_Chip-Seq_MCF-7_Human1.53438341
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52259106
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51095161
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.49244443
38* TP53_22127205_ChIP-Seq_IMR90_Human1.48952583
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48304597
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.47684948
41SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45926552
42SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45926552
43PKCTHETA_26484144_Chip-Seq_BREAST_Human1.45553252
44HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.44073496
45* RACK7_27058665_Chip-Seq_MCF-7_Human1.41022099
46DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.40978674
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38376191
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38376191
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38211884
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37781362
51* MITF_21258399_ChIP-Seq_MELANOMA_Human1.37703471
52* HNF4A_19822575_ChIP-Seq_HepG2_Human1.35039835
53HTT_18923047_ChIP-ChIP_STHdh_Human1.33250575
54FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.33010783
55KDM2B_26808549_Chip-Seq_K562_Human1.31886739
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.31813845
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31512725
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31357890
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28128481
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27350075
61BRD4_25478319_ChIP-Seq_HGPS_Human1.25992411
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25132276
63ESR1_21235772_ChIP-Seq_MCF-7_Human1.23319136
64* TP53_23651856_ChIP-Seq_MEFs_Mouse1.22579329
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22397932
66NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.21489021
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21470224
68* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21455662
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.20618718
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.17166287
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16611933
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16186987
73GATA4_25053715_ChIP-Seq_YYC3_Human1.16012856
74CJUN_26792858_Chip-Seq_BT549_Human1.15736154
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.12804269
76SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11867396
77P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11291114
78* KLF5_25053715_ChIP-Seq_YYC3_Human1.09874475
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.08271069
80* CHD1_26751641_Chip-Seq_LNCaP_Human1.07273662
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06975611
82* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06225729
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06188750
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05393683
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05222001
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.04866946
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04380611
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04173684
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04084591
90ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99713852
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99525929
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97930711
93TET1_21490601_ChIP-Seq_MESCs_Mouse0.96447977
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94914726
95* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94030834
96* SOX2_20726797_ChIP-Seq_SW620_Human0.92115814
97BCAT_22108803_ChIP-Seq_LS180_Human0.91692605
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91214684
99TBX20_22080862_ChIP-Seq_HEART_Mouse0.90532829
100TBX20_22328084_ChIP-Seq_HEART_Mouse0.90532829
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89367737
102AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85250727
103TCF4_18268006_ChIP-ChIP_LS174T_Human0.84569149
104CDX2_20551321_ChIP-Seq_CACO-2_Human0.84302702
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83675773
106* FOXA1_25552417_ChIP-Seq_VCAP_Human0.83416556
107SOX9_24532713_ChIP-Seq_HFSC_Mouse0.83312589
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.83174595
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.78531964
110* TP63_23658742_ChIP-Seq_EP156T_Human0.78465230
111Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77866328
112PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.77186238
113WT1_19549856_ChIP-ChIP_CCG9911_Human0.75603832
114GATA6_25053715_ChIP-Seq_YYC3_Human0.73825754
115FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.72459259
116CBP_21632823_ChIP-Seq_H3396_Human0.71774086
117CDX2_22108803_ChIP-Seq_LS180_Human0.71513310
118PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.70871733
119FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69043198
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.69008471
121FOXM1_26456572_ChIP-Seq_MCF-7_Human0.67899579
122JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67649839
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.66898798
124* GATA3_24758297_ChIP-Seq_MCF-7_Human0.64835984
125RXRA_24833708_ChIP-Seq_LIVER_Mouse0.64744537
126ESR1_15608294_ChIP-ChIP_MCF-7_Human0.64398192
127THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.64393492
128RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.64015080
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.63854103
130RXR_22108803_ChIP-Seq_LS180_Human0.63828005
131PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.63309772
132ISL1_27105846_Chip-Seq_CPCs_Mouse0.61032047
133TP53_16413492_ChIP-PET_HCT116_Human0.60926152
134FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.59799986
135* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.58886930
136RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.57793615
137ZNF263_19887448_ChIP-Seq_K562_Human0.57536865
138* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.57486450
139TP53_18474530_ChIP-ChIP_U2OS_Human0.56919672
140AR_21572438_ChIP-Seq_LNCaP_Human0.56124226
141SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.55753214
142AR_21909140_ChIP-Seq_LNCAP_Human0.55699592
143* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.55113923
144GATA2_21666600_ChIP-Seq_HMVEC_Human0.55066383
145AHR_22903824_ChIP-Seq_MCF-7_Human0.54943857
146STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.53687422
147HNFA_21074721_ChIP-Seq_CACO-2_Human0.53145155

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.90508764
2MP0005360_urolithiasis6.83687591
3MP0005171_absent_coat_pigmentation5.80759355
4MP0005365_abnormal_bile_salt5.30989527
5MP0005085_abnormal_gallbladder_physiolo5.25131883
6MP0008875_abnormal_xenobiotic_pharmacok4.06386730
7MP0003806_abnormal_nucleotide_metabolis3.82993297
8MP0003252_abnormal_bile_duct3.61671265
9MP0005409_darkened_coat_color3.43368910
10MP0010234_abnormal_vibrissa_follicle3.07898560
11MP0000015_abnormal_ear_pigmentation3.05800949
12MP0009840_abnormal_foam_cell2.96117270
13MP0010329_abnormal_lipoprotein_level2.95856853
14MP0001666_abnormal_nutrient_absorption2.82954683
15MP0008438_abnormal_cutaneous_collagen2.75303186
16MP0000569_abnormal_digit_pigmentation2.75208466
17MP0003705_abnormal_hypodermis_morpholog2.50481411
18MP0003195_calcinosis2.46475338
19MP0005332_abnormal_amino_acid2.42089314
20MP0005083_abnormal_biliary_tract2.41725788
21MP0000372_irregular_coat_pigmentation2.32417617
22MP0002877_abnormal_melanocyte_morpholog2.25566242
23MP0010352_gastrointestinal_tract_polyps2.21451090
24MP0000371_diluted_coat_color2.20401587
25MP0005174_abnormal_tail_pigmentation2.01005070
26MP0003136_yellow_coat_color1.93257686
27MP0002118_abnormal_lipid_homeostasis1.88763703
28MP0004019_abnormal_vitamin_homeostasis1.82639617
29MP0004381_abnormal_hair_follicle1.77447713
30MP0003868_abnormal_feces_composition1.76766154
31MP0009384_cardiac_valve_regurgitation1.76606284
32MP0000609_abnormal_liver_physiology1.74210145
33MP0005275_abnormal_skin_tensile1.73196492
34MP0002095_abnormal_skin_pigmentation1.71735686
35MP0003011_delayed_dark_adaptation1.70924327
36MP0005076_abnormal_cell_differentiation1.62885843
37MP0002075_abnormal_coat/hair_pigmentati1.60779953
38MP0003566_abnormal_cell_adhesion1.58114228
39MP0004858_abnormal_nervous_system1.57223826
40MP0000537_abnormal_urethra_morphology1.52478180
41MP0004264_abnormal_extraembryonic_tissu1.52334234
42MP0002089_abnormal_postnatal_growth/wei1.49673568
43MP0005503_abnormal_tendon_morphology1.49501618
44MP0005319_abnormal_enzyme/_coenzyme1.47088022
45MP0000534_abnormal_ureter_morphology1.45916002
46MP0003191_abnormal_cellular_cholesterol1.45908553
47MP0003091_abnormal_cell_migration1.44136316
48MP0005451_abnormal_body_composition1.43289297
49MP0010678_abnormal_skin_adnexa1.39798040
50MP0001186_pigmentation_phenotype1.36643671
51MP0005670_abnormal_white_adipose1.36436578
52MP0001348_abnormal_lacrimal_gland1.33879601
53MP0002837_dystrophic_cardiac_calcinosis1.32784720
54MP0004233_abnormal_muscle_weight1.26532012
55MP0003950_abnormal_plasma_membrane1.22336798
56MP0000003_abnormal_adipose_tissue1.20643017
57MP0001849_ear_inflammation1.19091129
58MP0003453_abnormal_keratinocyte_physiol1.18117490
59MP0000733_abnormal_muscle_development1.17946104
60MP0005075_abnormal_melanosome_morpholog1.16938724
61MP0009697_abnormal_copulation1.13666835
62MP0010368_abnormal_lymphatic_system1.12624551
63MP0001764_abnormal_homeostasis1.12588192
64MP0009643_abnormal_urine_homeostasis1.12447111
65MP0002060_abnormal_skin_morphology1.11620133
66MP0000383_abnormal_hair_follicle1.10313533
67MP0008057_abnormal_DNA_replication1.07541380
68MP0005666_abnormal_adipose_tissue1.05948306
69MP0005584_abnormal_enzyme/coenzyme_acti1.05761133
70MP0002138_abnormal_hepatobiliary_system1.04410226
71MP0003279_aneurysm1.02328487
72MP0001661_extended_life_span1.01079938
73MP0002254_reproductive_system_inflammat1.00533763
74MP0000467_abnormal_esophagus_morphology1.00092885
75MP0005623_abnormal_meninges_morphology0.99122633
76MP0004185_abnormal_adipocyte_glucose0.95934622
77MP0005220_abnormal_exocrine_pancreas0.95717957
78MP0000377_abnormal_hair_follicle0.95418414
79MP0002938_white_spotting0.95300791
80MP0004130_abnormal_muscle_cell0.94105275
81MP0005408_hypopigmentation0.93810520
82MP0002098_abnormal_vibrissa_morphology0.93165062
83MP0000462_abnormal_digestive_system0.92492484
84MP0001324_abnormal_eye_pigmentation0.90769724
85MP0002295_abnormal_pulmonary_circulatio0.90288283
86MP0002009_preneoplasia0.90025897
87MP0005197_abnormal_uvea_morphology0.90021791
88MP0005647_abnormal_sex_gland0.86702501
89MP0002168_other_aberrant_phenotype0.85309463
90MP0000604_amyloidosis0.84980813
91MP0009053_abnormal_anal_canal0.84929460
92MP0000678_abnormal_parathyroid_gland0.84454396
93MP0002896_abnormal_bone_mineralization0.84250786
94MP0000579_abnormal_nail_morphology0.83917431
95MP0000598_abnormal_liver_morphology0.83807474
96MP0000432_abnormal_head_morphology0.83466463
97MP0003111_abnormal_nucleus_morphology0.83382866
98MP0003115_abnormal_respiratory_system0.83205816
99MP0002249_abnormal_larynx_morphology0.82214811
100MP0003937_abnormal_limbs/digits/tail_de0.80612424
101MP0005501_abnormal_skin_physiology0.79783993
102MP0002177_abnormal_outer_ear0.79683986
103MP0003941_abnormal_skin_development0.77815912
104MP0001216_abnormal_epidermal_layer0.76204770
105MP0003329_amyloid_beta_deposits0.75006598
106MP0005257_abnormal_intraocular_pressure0.74918030
107MP0005023_abnormal_wound_healing0.73973961
108MP0002971_abnormal_brown_adipose0.73891860
109MP0002108_abnormal_muscle_morphology0.72415267
110MP0002269_muscular_atrophy0.71641453
111MP0005395_other_phenotype0.71515832
112MP0004272_abnormal_basement_membrane0.70834734
113MP0001756_abnormal_urination0.70439336
114MP0001542_abnormal_bone_strength0.70365903
115MP0003656_abnormal_erythrocyte_physiolo0.68960224
116MP0002796_impaired_skin_barrier0.68953385
117MP0000627_abnormal_mammary_gland0.68721513
118MP0004134_abnormal_chest_morphology0.68666939
119MP0002078_abnormal_glucose_homeostasis0.68394019
120MP0001243_abnormal_dermal_layer0.67062500
121MP0005375_adipose_tissue_phenotype0.66866389
122MP0002086_abnormal_extraembryonic_tissu0.66661104
123MP0003077_abnormal_cell_cycle0.66055542
124MP0005621_abnormal_cell_physiology0.65915035
125MP0003045_fibrosis0.65565096
126MP0009763_increased_sensitivity_to0.65320128
127MP0000367_abnormal_coat/_hair0.64513931
128MP0005187_abnormal_penis_morphology0.64455503
129MP0005330_cardiomyopathy0.64413242
130MP0002084_abnormal_developmental_patter0.64376608
131MP0001915_intracranial_hemorrhage0.63741332
132MP0000013_abnormal_adipose_tissue0.63592463
133MP0000428_abnormal_craniofacial_morphol0.63371260
134MP0005410_abnormal_fertilization0.63107400
135MP0005334_abnormal_fat_pad0.63087832
136MP0003690_abnormal_glial_cell0.62630487
137MP0010771_integument_phenotype0.62557868
138MP0001958_emphysema0.62038046
139MP0000538_abnormal_urinary_bladder0.61800156
140MP0002697_abnormal_eye_size0.60653914
141MP0000762_abnormal_tongue_morphology0.60622068
142MP0010307_abnormal_tumor_latency0.60516181
143MP0005058_abnormal_lysosome_morphology0.60459061
144MP0002114_abnormal_axial_skeleton0.60448306
145MP0005380_embryogenesis_phenotype0.59760945
146MP0001672_abnormal_embryogenesis/_devel0.59760945
147MP0003984_embryonic_growth_retardation0.59659800
148MP0003385_abnormal_body_wall0.59446904
149MP0003935_abnormal_craniofacial_develop0.58798584
150MP0009780_abnormal_chondrocyte_physiolo0.58430715
151MP0005636_abnormal_mineral_homeostasis0.58374910
152MP0009642_abnormal_blood_homeostasis0.58249936
153MP0005551_abnormal_eye_electrophysiolog0.57064802
154MP0003300_gastrointestinal_ulcer0.56794272
155MP0005376_homeostasis/metabolism_phenot0.55362147
156MP0005084_abnormal_gallbladder_morpholo0.54850684
157MP0010030_abnormal_orbit_morphology0.53046882
158MP0005448_abnormal_energy_balance0.53014632
159MP0006138_congestive_heart_failure0.52228506
160MP0000427_abnormal_hair_cycle0.51831457
161MP0000566_synostosis0.51539503
162MP0003186_abnormal_redox_activity0.50625951
163MP0005248_abnormal_Harderian_gland0.47633625
164MP0009672_abnormal_birth_weight0.46816382
165MP0002876_abnormal_thyroid_physiology0.46759711
166MP0000747_muscle_weakness0.46421675
167MP0009764_decreased_sensitivity_to0.45919671
168MP0002090_abnormal_vision0.45869623
169MP0005508_abnormal_skeleton_morphology0.45316761
170MP0009115_abnormal_fat_cell0.44542808
171MP0004087_abnormal_muscle_fiber0.43761602
172MP0000163_abnormal_cartilage_morphology0.43062692
173MP0000230_abnormal_systemic_arterial0.43027643
174MP0001299_abnormal_eye_distance/0.43026062

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.26490445
2Deep venous thrombosis (HP:0002625)6.16835642
3Xanthomatosis (HP:0000991)5.81998904
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.60098775
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.19523955
6Hypobetalipoproteinemia (HP:0003563)5.07453698
7Prolonged partial thromboplastin time (HP:0003645)4.88407446
8Hyperlipoproteinemia (HP:0010980)4.45819895
9Hypolipoproteinemia (HP:0010981)4.26824309
10Hypoalphalipoproteinemia (HP:0003233)4.06804411
11Complement deficiency (HP:0004431)4.04556031
12Epidermoid cyst (HP:0200040)3.95096400
13Hyperglycinuria (HP:0003108)3.93417734
14Abnormality of glutamine family amino acid metabolism (HP:0010902)3.85947125
15Abnormality of serine family amino acid metabolism (HP:0010894)3.85413992
16Abnormality of glycine metabolism (HP:0010895)3.85413992
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.83386935
18Fat malabsorption (HP:0002630)3.81821140
19Hyperglycinemia (HP:0002154)3.81246213
20Hyperammonemia (HP:0001987)3.77927210
21Ketosis (HP:0001946)3.75209936
22Blue irides (HP:0000635)3.72401588
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.72185747
24Abnormality of the common coagulation pathway (HP:0010990)3.69414148
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.68931175
26Hypoglycemic coma (HP:0001325)3.68856971
27White forelock (HP:0002211)3.57461819
28Abnormality of methionine metabolism (HP:0010901)3.53210044
29Abnormality of the intrinsic pathway (HP:0010989)3.37171279
30Hypopigmentation of the fundus (HP:0007894)3.36465537
31Premature rupture of membranes (HP:0001788)3.27652971
32Conjugated hyperbilirubinemia (HP:0002908)3.24718052
33Protrusio acetabuli (HP:0003179)3.24632134
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.16673404
35Abnormality of fatty-acid metabolism (HP:0004359)3.16192610
36Patchy hypopigmentation of hair (HP:0011365)3.04402800
37Myocardial infarction (HP:0001658)2.98529946
38Ketoacidosis (HP:0001993)2.95335317
39Hypercholesterolemia (HP:0003124)2.93811814
40Skin nodule (HP:0200036)2.90722152
41Ulnar bowing (HP:0003031)2.87594860
42Joint hemorrhage (HP:0005261)2.86624682
43Hypoplasia of the iris (HP:0007676)2.84587993
44Abnormality of complement system (HP:0005339)2.81697659
45Cerebral aneurysm (HP:0004944)2.76546908
46Steatorrhea (HP:0002570)2.72271535
47Shallow orbits (HP:0000586)2.69229894
48Mitral stenosis (HP:0001718)2.62158526
49Flat acetabular roof (HP:0003180)2.57829193
50Cardiovascular calcification (HP:0011915)2.54421480
51Gout (HP:0001997)2.48228854
52Peritonitis (HP:0002586)2.47631085
53Abnormality of serum amino acid levels (HP:0003112)2.46887379
54Hyperglycemia (HP:0003074)2.44386710
55Abnormality of purine metabolism (HP:0004352)2.43886494
56Vascular calcification (HP:0004934)2.39082153
57Hyperbilirubinemia (HP:0002904)2.38806000
58Pigmentary retinal degeneration (HP:0001146)2.37517830
59Abnormality of nucleobase metabolism (HP:0010932)2.36981223
60Hypoglycemic seizures (HP:0002173)2.34798612
61Hepatocellular carcinoma (HP:0001402)2.34061482
62Ocular albinism (HP:0001107)2.33578073
63Malnutrition (HP:0004395)2.33086570
64Acanthocytosis (HP:0001927)2.31873006
65Turricephaly (HP:0000262)2.31150035
66Dicarboxylic aciduria (HP:0003215)2.26778403
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.26778403
68Thin bony cortex (HP:0002753)2.26713000
69Dysmetric saccades (HP:0000641)2.26107857
70Hyperacusis (HP:0010780)2.25679942
71Abnormality of the distal phalanges of the toes (HP:0010182)2.25312566
72Right ventricular cardiomyopathy (HP:0011663)2.23619593
73Abnormality of pyrimidine metabolism (HP:0004353)2.23170682
74Abnormality of the distal phalanx of the thumb (HP:0009617)2.22090585
75Spontaneous abortion (HP:0005268)2.21131874
76Atrophic scars (HP:0001075)2.20667334
77Chorioretinal atrophy (HP:0000533)2.18365197
78Neonatal short-limb short stature (HP:0008921)2.18214207
79Abnormality of proline metabolism (HP:0010907)2.17149002
80Hydroxyprolinuria (HP:0003080)2.17149002
81Metabolic acidosis (HP:0001942)2.17030953
82Abnormality of the nasal septum (HP:0000419)2.14706870
83Broad face (HP:0000283)2.13782727
84Distal upper limb amyotrophy (HP:0007149)2.13262694
85Upper limb amyotrophy (HP:0009129)2.13262694
86Abnormality of the phalanges of the hallux (HP:0010057)2.13030567
87Renovascular hypertension (HP:0100817)2.11924003
88Hypophosphatemic rickets (HP:0004912)2.11092251
89Abnormal gallbladder morphology (HP:0012437)2.10793384
90Ileus (HP:0002595)2.09168683
91Sensorimotor neuropathy (HP:0007141)2.08159581
92Persistence of primary teeth (HP:0006335)2.08044288
93Hyperinsulinemic hypoglycemia (HP:0000825)2.05492517
94Protuberant abdomen (HP:0001538)2.05246598
95Delayed CNS myelination (HP:0002188)2.03345782
96Hand muscle atrophy (HP:0009130)2.01765821
97Abnormal auditory evoked potentials (HP:0006958)2.01752481
98Rickets (HP:0002748)2.01226571
99Cholelithiasis (HP:0001081)2.00756999
100Hypochromic microcytic anemia (HP:0004840)2.00383168
101Abnormal cartilage morphology (HP:0002763)1.99074783
102Hyperkalemia (HP:0002153)1.98879973
103Cervical subluxation (HP:0003308)1.98668108
104Advanced eruption of teeth (HP:0006288)1.98441450
105Abnormal delivery (HP:0001787)1.97582692
106Ectopia lentis (HP:0001083)1.94925764
107Natal tooth (HP:0000695)1.94637112
108Heterotopia (HP:0002282)1.93732432
109Lethargy (HP:0001254)1.92974917
110Infantile muscular hypotonia (HP:0008947)1.91034120
111Tibial bowing (HP:0002982)1.90688214
112Lip pit (HP:0100267)1.89454837
113Hyporeflexia of lower limbs (HP:0002600)1.89286087
114Enlarged kidneys (HP:0000105)1.89155727
115Broad metatarsal (HP:0001783)1.88988093
116Bell-shaped thorax (HP:0001591)1.88225260
117Congenital sensorineural hearing impairment (HP:0008527)1.87447023
118Amyloidosis (HP:0011034)1.87095135
119Bladder diverticulum (HP:0000015)1.86671488
120Relative macrocephaly (HP:0004482)1.85902290
121Long toe (HP:0010511)1.85354815
122Aortic aneurysm (HP:0004942)1.84434449
123Aortic dissection (HP:0002647)1.83954302
124Increased connective tissue (HP:0009025)1.81420166
125Systemic lupus erythematosus (HP:0002725)1.80622165
126Proximal tubulopathy (HP:0000114)1.80363821
127Wormian bones (HP:0002645)1.79570963
128Cupped ribs (HP:0000887)1.79109051
129Fragile skin (HP:0001030)1.78790613
130Elbow flexion contracture (HP:0002987)1.77790398
131Short nail (HP:0001799)1.77413939
132Abnormality of the acetabulum (HP:0003170)1.76303073
133Irritability (HP:0000737)1.76061889
134Abnormality of the gallbladder (HP:0005264)1.75951997
135Esophageal varix (HP:0002040)1.75534921
136Termporal pattern (HP:0011008)1.75398982
137Insidious onset (HP:0003587)1.75398982
138Late onset (HP:0003584)1.73960518
139Osteolytic defects of the hand bones (HP:0009699)1.73695020
140Osteolytic defects of the phalanges of the hand (HP:0009771)1.73695020
141Increased purine levels (HP:0004368)1.73157610
142Hyperuricemia (HP:0002149)1.73157610
143Biconcave vertebral bodies (HP:0004586)1.72209357
144Underdeveloped nasal alae (HP:0000430)1.72077141
145Renal cortical cysts (HP:0000803)1.70162978
146Macroorchidism (HP:0000053)1.70140242
147Cholecystitis (HP:0001082)1.69465023
148Abnormal gallbladder physiology (HP:0012438)1.69465023
149Symptomatic seizures (HP:0011145)1.69295711
150Synophrys (HP:0000664)1.68963404
151Glycosuria (HP:0003076)1.68632302
152Abnormality of urine glucose concentration (HP:0011016)1.68632302
153Vertebral arch anomaly (HP:0008438)1.68421777
154Genetic anticipation (HP:0003743)1.67608404
155Iris hypopigmentation (HP:0007730)1.64411407
156Long eyelashes (HP:0000527)1.63451165
157Abnormality of carpal bone ossification (HP:0006257)1.63349035
158Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.62582959
159Dislocated radial head (HP:0003083)1.62369290
160Overgrowth (HP:0001548)1.62107479
161Freckling (HP:0001480)1.61562018
162Bowing of the arm (HP:0006488)1.61532229
163Bowed forearm bones (HP:0003956)1.61532229
164Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.61202657
165Disproportionate tall stature (HP:0001519)1.60889504
166Generalized hypopigmentation of hair (HP:0011358)1.60815481
167Asymmetry of the thorax (HP:0001555)1.60528354
168Hamartoma of the eye (HP:0010568)1.60282379
169Heterochromia iridis (HP:0001100)1.58494896
170Laryngomalacia (HP:0001601)1.57464887
171Germ cell neoplasia (HP:0100728)1.56555573
172Abnormality of the epiphyses of the hand (HP:0005924)1.55630484
173Abnormal ossification of hand bones (HP:0005921)1.54171298
174Arterial tortuosity (HP:0005116)1.54075411
175Mitral valve prolapse (HP:0001634)1.53736912
176Aneurysm (HP:0002617)1.53633753
177Decreased lacrimation (HP:0000633)1.53534160
178Mildly elevated creatine phosphokinase (HP:0008180)1.52934107
179Aplasia involving bones of the extremities (HP:0009825)1.52612597
180Aplasia involving bones of the upper limbs (HP:0009823)1.52612597
181Aplasia of the phalanges of the hand (HP:0009802)1.52612597
182Abnormality of dentin (HP:0010299)1.51671884
183Bilateral sensorineural hearing impairment (HP:0008619)1.49034869
184Joint laxity (HP:0001388)1.48674356
185Aplasia/Hypoplasia of the macula (HP:0008059)1.48485376
186Coarse hair (HP:0002208)1.45215077
187Spinal cord compression (HP:0002176)1.45161225
188Vascular tortuosity (HP:0004948)1.44971380
189Sandal gap (HP:0001852)1.44305174
190Sparse lateral eyebrow (HP:0005338)1.44036769
191Blue sclerae (HP:0000592)1.42800002
192Limited elbow extension (HP:0001377)1.41558966
193Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.41193513
194Narrow palate (HP:0000189)1.41143547
195Alacrima (HP:0000522)1.40301250
196Abdominal distention (HP:0003270)1.40224403
197Abnormality of the fingertips (HP:0001211)1.40160906

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK14.73218614
2CDK124.38994225
3BCKDK3.97733515
4LATS13.75789152
5ERN13.47051606
6EEF2K2.87853530
7FGFR42.71155197
8FRK2.35821066
9INSRR2.31643013
10DDR22.29489148
11BRD42.18516162
12ERBB42.13082394
13EPHB12.06277697
14TRIB32.01645395
15TAOK31.97698378
16TTN1.95246173
17STK38L1.93063781
18FGFR21.89707040
19LMTK21.87785926
20SMG11.69520221
21MST1R1.67741031
22PIK3CA1.63323073
23EPHA31.62384561
24PNCK1.58703994
25PDGFRA1.53279844
26PIK3CG1.50626319
27MET1.50600929
28PTK61.48668084
29NEK91.45680037
30PRKD31.40063622
31PBK1.39253556
32PAK31.36084119
33CAMK1D1.31596826
34LATS21.25172877
35PRKAA21.20149346
36MAP3K31.18860676
37PTK21.15689862
38STK31.14644743
39AKT31.12170152
40MAPK111.09671335
41CDK71.06046778
42FGFR11.04167369
43FER1.03341507
44STK391.00990311
45JAK10.99424540
46CAMK1G0.98825577
47ERBB20.96502950
48MTOR0.96335648
49PDPK10.95675962
50WNK40.95354676
51PKN20.94053142
52PDK30.92227214
53PDK40.92227214
54PRKD20.92185593
55NUAK10.91858784
56CDC42BPA0.87915704
57BMX0.87340467
58PRKAA10.86742002
59MAP3K70.86245423
60TBK10.85696990
61PAK20.84909324
62PRKD10.82425202
63IRAK30.82288323
64RPS6KA20.80622027
65MAPKAPK30.80176504
66PKN10.78948881
67ABL20.77656818
68ICK0.77600168
69MAP2K40.77125474
70WEE10.75369790
71EPHB20.75138639
72PDGFRB0.74411218
73MAP2K10.73331896
74PAK40.69856290
75PDK20.69459240
76MAPKAPK50.68696878
77MAP2K20.68407047
78MAPK120.66980274
79NEK60.66837207
80RIPK10.65791433
81MAP3K100.65370379
82TRPM70.64223179
83CDK90.63029317
84TYRO30.62749404
85CDK60.62740961
86FGFR30.62692084
87MAP3K20.60699388
88RPS6KB10.60007987
89CHEK10.59232556
90EPHA20.58418518
91OXSR10.56127658
92ROCK10.54866204
93PHKG10.53597166
94PHKG20.53597166
95MARK20.53172121
96OBSCN0.53019402
97SGK2230.52807668
98SGK4940.52807668
99SGK30.52397349
100PRKACG0.52211386
101TTK0.51567107
102WNK10.51238949
103CSNK1A1L0.50520154
104DMPK0.49438949
105NEK10.49354781
106ACVR1B0.49127190
107PRPF4B0.48276222
108GSK3A0.48117462
109AKT20.45952166
110CHUK0.45491695
111CAMK2G0.44344691
112BRSK20.43592241
113JAK20.43038177
114IGF1R0.42921486
115NTRK10.42172247
116KSR20.40846787
117SCYL20.40044937
118GSK3B0.39792925
119RET0.39520277
120TAOK20.38870351
121PRKCZ0.38588558
122MAPK70.38413430
123MELK0.38274335
124MYLK0.38243860
125CDK10.37808809
126CAMK2D0.37317700
127MAP3K80.36072269
128PLK40.35927655
129MAPK100.35560079
130PRKG20.35469409
131GRK10.35189861
132PDK10.34866097
133MAPK10.34381717
134DYRK1B0.34072819
135SGK20.33582356
136CHEK20.32726853
137PAK60.31519135
138PLK20.30896539
139STK380.30702902
140MAPK140.30457409
141PINK10.30403326
142CDK20.30336568
143MAPK80.30256059
144PRKCH0.29757221
145SGK10.28435208

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.89338436
2Nitrogen metabolism_Homo sapiens_hsa009103.53661815
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.04127686
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.74567633
5Arginine biosynthesis_Homo sapiens_hsa002202.72454035
6Fatty acid degradation_Homo sapiens_hsa000712.69192527
7Tryptophan metabolism_Homo sapiens_hsa003802.54112939
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.53522516
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.52791385
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.48338762
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44800961
12Complement and coagulation cascades_Homo sapiens_hsa046102.36880526
13Butanoate metabolism_Homo sapiens_hsa006502.19025378
14Propanoate metabolism_Homo sapiens_hsa006402.17994097
15Fatty acid metabolism_Homo sapiens_hsa012122.10886798
16PPAR signaling pathway_Homo sapiens_hsa033202.01449091
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.95817112
18Peroxisome_Homo sapiens_hsa041461.89628588
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83312410
20Caffeine metabolism_Homo sapiens_hsa002321.79910584
21Histidine metabolism_Homo sapiens_hsa003401.76731038
22Small cell lung cancer_Homo sapiens_hsa052221.76402659
23Sulfur metabolism_Homo sapiens_hsa009201.72718826
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69037410
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.64834859
26MicroRNAs in cancer_Homo sapiens_hsa052061.64184555
27Chemical carcinogenesis_Homo sapiens_hsa052041.63723815
28Thyroid hormone signaling pathway_Homo sapiens_hsa049191.60205894
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58398400
30beta-Alanine metabolism_Homo sapiens_hsa004101.57111310
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57110527
32Bile secretion_Homo sapiens_hsa049761.55167907
33Steroid biosynthesis_Homo sapiens_hsa001001.54589279
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53594277
35* Adherens junction_Homo sapiens_hsa045201.53240565
36Retinol metabolism_Homo sapiens_hsa008301.51505613
37Fatty acid elongation_Homo sapiens_hsa000621.50998885
38Starch and sucrose metabolism_Homo sapiens_hsa005001.46626588
39Fat digestion and absorption_Homo sapiens_hsa049751.46316063
40Pyruvate metabolism_Homo sapiens_hsa006201.45056292
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44499106
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43955526
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.40269663
44Prostate cancer_Homo sapiens_hsa052151.37092476
45Selenocompound metabolism_Homo sapiens_hsa004501.34181275
46Vitamin B6 metabolism_Homo sapiens_hsa007501.30378662
47Thyroid cancer_Homo sapiens_hsa052161.30092946
48Vitamin digestion and absorption_Homo sapiens_hsa049771.27219009
49Phenylalanine metabolism_Homo sapiens_hsa003601.25069578
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24419952
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.21944643
52Folate biosynthesis_Homo sapiens_hsa007901.21029298
53Carbon metabolism_Homo sapiens_hsa012001.20085685
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18886672
55Tyrosine metabolism_Homo sapiens_hsa003501.18846492
56Chronic myeloid leukemia_Homo sapiens_hsa052201.18426125
57ABC transporters_Homo sapiens_hsa020101.18026827
58Arginine and proline metabolism_Homo sapiens_hsa003301.17636131
59Staphylococcus aureus infection_Homo sapiens_hsa051501.16220163
60Biosynthesis of amino acids_Homo sapiens_hsa012301.15750073
61Proteoglycans in cancer_Homo sapiens_hsa052051.15584583
62Glioma_Homo sapiens_hsa052141.14206238
63Endometrial cancer_Homo sapiens_hsa052131.14002311
64mTOR signaling pathway_Homo sapiens_hsa041501.13490649
65Inositol phosphate metabolism_Homo sapiens_hsa005621.12324277
66Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11790966
67Cysteine and methionine metabolism_Homo sapiens_hsa002701.10326013
68ErbB signaling pathway_Homo sapiens_hsa040121.05752597
69Dorso-ventral axis formation_Homo sapiens_hsa043201.05095749
70Lysine degradation_Homo sapiens_hsa003101.04292221
71Sphingolipid metabolism_Homo sapiens_hsa006001.03826454
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03765796
73Fatty acid biosynthesis_Homo sapiens_hsa000611.00539473
74Notch signaling pathway_Homo sapiens_hsa043301.00220134
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99389372
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96589081
77Non-small cell lung cancer_Homo sapiens_hsa052230.96026771
78Choline metabolism in cancer_Homo sapiens_hsa052310.94740373
79TGF-beta signaling pathway_Homo sapiens_hsa043500.94654047
80Glycerolipid metabolism_Homo sapiens_hsa005610.93606305
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.90132721
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88807240
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87932560
84Tight junction_Homo sapiens_hsa045300.85181002
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83812534
86Melanogenesis_Homo sapiens_hsa049160.80577437
87Estrogen signaling pathway_Homo sapiens_hsa049150.80074886
88Hippo signaling pathway_Homo sapiens_hsa043900.79614176
89VEGF signaling pathway_Homo sapiens_hsa043700.77215987
90Melanoma_Homo sapiens_hsa052180.76190481
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75918703
92Viral carcinogenesis_Homo sapiens_hsa052030.72843862
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72405126
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.71948068
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70846818
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70221033
97Other glycan degradation_Homo sapiens_hsa005110.69358778
98Renal cell carcinoma_Homo sapiens_hsa052110.67690948
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66388031
100Prolactin signaling pathway_Homo sapiens_hsa049170.66247322
101Axon guidance_Homo sapiens_hsa043600.64331506
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.63117510
103Pancreatic secretion_Homo sapiens_hsa049720.62803945
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62650028
105Glutathione metabolism_Homo sapiens_hsa004800.61301826
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.61078341
107Pancreatic cancer_Homo sapiens_hsa052120.59506630
108Cell cycle_Homo sapiens_hsa041100.59067518
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58814463
110Type II diabetes mellitus_Homo sapiens_hsa049300.58742790
111GnRH signaling pathway_Homo sapiens_hsa049120.58145267
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57948396
113Pentose phosphate pathway_Homo sapiens_hsa000300.55581696
114Protein digestion and absorption_Homo sapiens_hsa049740.54719500
115Pathways in cancer_Homo sapiens_hsa052000.53642997
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52502214
117Hepatitis C_Homo sapiens_hsa051600.52430773
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51659924
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51445118
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48583355
121FoxO signaling pathway_Homo sapiens_hsa040680.47509335
122Galactose metabolism_Homo sapiens_hsa000520.44055054
123Metabolic pathways_Homo sapiens_hsa011000.43739881
124Insulin resistance_Homo sapiens_hsa049310.43013305
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42127804
126Fructose and mannose metabolism_Homo sapiens_hsa000510.42050059
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.41284423
128Sulfur relay system_Homo sapiens_hsa041220.40552995
129ECM-receptor interaction_Homo sapiens_hsa045120.40047749
130One carbon pool by folate_Homo sapiens_hsa006700.38556384
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.32551360
132Linoleic acid metabolism_Homo sapiens_hsa005910.29943017
133Mineral absorption_Homo sapiens_hsa049780.29686098
134Phototransduction_Homo sapiens_hsa047440.26753004
135Renin-angiotensin system_Homo sapiens_hsa046140.25032899
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23351086
137AMPK signaling pathway_Homo sapiens_hsa041520.22391191
138Prion diseases_Homo sapiens_hsa050200.21868128
139Glucagon signaling pathway_Homo sapiens_hsa049220.21372931
140Ovarian steroidogenesis_Homo sapiens_hsa049130.18020439
141Amoebiasis_Homo sapiens_hsa051460.15967204
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14070452
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12828481
144Circadian rhythm_Homo sapiens_hsa047100.10022761
145Glycosaminoglycan degradation_Homo sapiens_hsa005310.06181132
146Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.04101655
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.03811995
148Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.02761056
149Bladder cancer_Homo sapiens_hsa052190.00989056
150Ether lipid metabolism_Homo sapiens_hsa005650.00085295
151Insulin signaling pathway_Homo sapiens_hsa04910-0.0455947
152Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0130858
153Dilated cardiomyopathy_Homo sapiens_hsa05414-0.0069704
154Focal adhesion_Homo sapiens_hsa04510-0.0058281

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