FARS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that transfers phenylalanine to its cognate tRNA. This protein localizes to the mitochondrion and plays a role in mitochondrial protein translation. Mutations in this gene can cause combined oxidative phosphorylation deficiency 14 (Alpers encephalopathy). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular ketone body metabolic process (GO:0046950)5.30295406
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.05128572
3L-phenylalanine catabolic process (GO:0006559)5.05128572
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.95532485
5L-phenylalanine metabolic process (GO:0006558)4.95532485
6lysine metabolic process (GO:0006553)4.85298074
7lysine catabolic process (GO:0006554)4.85298074
8tricarboxylic acid cycle (GO:0006099)4.85009062
9ketone body metabolic process (GO:1902224)4.55602177
10proteasome assembly (GO:0043248)4.55213905
11fatty acid beta-oxidation (GO:0006635)4.45159056
12fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.39216209
13branched-chain amino acid catabolic process (GO:0009083)4.39109511
14cysteine metabolic process (GO:0006534)4.35861593
15aromatic amino acid family catabolic process (GO:0009074)4.34894835
16glyoxylate metabolic process (GO:0046487)4.33721372
17valine metabolic process (GO:0006573)4.31107743
18protein neddylation (GO:0045116)4.30405497
19short-chain fatty acid metabolic process (GO:0046459)4.26425926
20DNA deamination (GO:0045006)4.23483791
21chaperone-mediated protein transport (GO:0072321)4.23386401
22aspartate family amino acid catabolic process (GO:0009068)4.20014622
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.18634752
24oxidative phosphorylation (GO:0006119)4.16882633
25cullin deneddylation (GO:0010388)4.13882894
26alpha-linolenic acid metabolic process (GO:0036109)4.11797133
272-oxoglutarate metabolic process (GO:0006103)4.10470853
28pseudouridine synthesis (GO:0001522)4.08360278
29sulfur amino acid catabolic process (GO:0000098)4.04895833
30fatty acid catabolic process (GO:0009062)4.03613666
31amino-acid betaine metabolic process (GO:0006577)4.02469769
32fatty acid oxidation (GO:0019395)3.98601739
33lipid oxidation (GO:0034440)3.98293629
34branched-chain amino acid metabolic process (GO:0009081)3.98215549
35indole-containing compound catabolic process (GO:0042436)3.93396598
36indolalkylamine catabolic process (GO:0046218)3.93396598
37tryptophan catabolic process (GO:0006569)3.93396598
38positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.92471967
39kynurenine metabolic process (GO:0070189)3.92458267
40triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.92128026
41mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.86099959
42carnitine metabolic process (GO:0009437)3.83286114
43regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.82777597
44protein deneddylation (GO:0000338)3.81812047
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.81210674
46tryptophan metabolic process (GO:0006568)3.78628115
47NADH metabolic process (GO:0006734)3.72371704
48bile acid biosynthetic process (GO:0006699)3.71962306
49succinate metabolic process (GO:0006105)3.70832173
50monocarboxylic acid catabolic process (GO:0072329)3.70421016
51negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.70060128
52negative regulation of ligase activity (GO:0051352)3.70060128
53rRNA modification (GO:0000154)3.64842082
54alpha-amino acid catabolic process (GO:1901606)3.64695557
55regulation of cellular amino acid metabolic process (GO:0006521)3.64472648
56protein complex biogenesis (GO:0070271)3.62390880
57serine family amino acid catabolic process (GO:0009071)3.61023871
58signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.60654894
59signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.60654894
60signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.60654894
61acetyl-CoA metabolic process (GO:0006084)3.60572384
62DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.59300602
63ethanol oxidation (GO:0006069)3.58524283
64nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.58033396
65anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.56991415
66regulation of triglyceride catabolic process (GO:0010896)3.55443378
67base-excision repair, AP site formation (GO:0006285)3.55256860
68serine family amino acid biosynthetic process (GO:0009070)3.52383325
69tricarboxylic acid metabolic process (GO:0072350)3.52251646
70intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.51936648
71signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.51936648
72cellular amino acid catabolic process (GO:0009063)3.50540828
73mitochondrial respiratory chain complex assembly (GO:0033108)3.48208280
74serine family amino acid metabolic process (GO:0009069)3.48133599
75signal transduction involved in DNA damage checkpoint (GO:0072422)3.47365838
76signal transduction involved in DNA integrity checkpoint (GO:0072401)3.47365838
77urea cycle (GO:0000050)3.47317420
78urea metabolic process (GO:0019627)3.47317420
79positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.46045626
80oxaloacetate metabolic process (GO:0006107)3.45764929
81energy coupled proton transport, down electrochemical gradient (GO:0015985)3.45577585
82ATP synthesis coupled proton transport (GO:0015986)3.45577585
83fructose metabolic process (GO:0006000)3.45128557
84organic acid catabolic process (GO:0016054)3.44224012
85carboxylic acid catabolic process (GO:0046395)3.44224012
86transcription elongation from RNA polymerase III promoter (GO:0006385)3.43056447
87termination of RNA polymerase III transcription (GO:0006386)3.43056447
88glycine metabolic process (GO:0006544)3.41233160
89signal transduction involved in cell cycle checkpoint (GO:0072395)3.41204181
90regulation of mitochondrial translation (GO:0070129)3.37708884
91exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.36346649
92positive regulation of ligase activity (GO:0051351)3.34179154
93purine deoxyribonucleotide catabolic process (GO:0009155)3.31084448
94ribosome assembly (GO:0042255)3.30817834
95low-density lipoprotein particle remodeling (GO:0034374)3.30749368
96respiratory electron transport chain (GO:0022904)3.30666838
97carnitine shuttle (GO:0006853)3.29392816
98homocysteine metabolic process (GO:0050667)3.26413313
99protein targeting to mitochondrion (GO:0006626)3.25673044
100nitrogen cycle metabolic process (GO:0071941)3.25373769
101deoxyribonucleotide catabolic process (GO:0009264)3.25098853
102telomere maintenance via semi-conservative replication (GO:0032201)3.24333875
103respiratory chain complex IV assembly (GO:0008535)3.24213517
104electron transport chain (GO:0022900)3.24176606
105coenzyme catabolic process (GO:0009109)3.24124832
106fatty acid transmembrane transport (GO:1902001)3.23387595
107ribosomal small subunit assembly (GO:0000028)3.22475860
108regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.20946862
109biotin metabolic process (GO:0006768)3.20410013
110deoxyribose phosphate catabolic process (GO:0046386)3.19317490
111cellular modified amino acid catabolic process (GO:0042219)3.16562960
112aromatic amino acid family metabolic process (GO:0009072)3.16329036
113bile acid metabolic process (GO:0008206)3.13818654
114antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.13517975
115NAD metabolic process (GO:0019674)3.10686072
116protein-lipid complex remodeling (GO:0034368)3.08845383
117macromolecular complex remodeling (GO:0034367)3.08845383
118plasma lipoprotein particle remodeling (GO:0034369)3.08845383
119mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.07509042
120acyl-CoA metabolic process (GO:0006637)3.05027815
121thioester metabolic process (GO:0035383)3.05027815
122autophagic vacuole fusion (GO:0000046)3.04371717
123reverse cholesterol transport (GO:0043691)3.04035864
124amino-acid betaine transport (GO:0015838)3.03236161
125carnitine transport (GO:0015879)3.03236161
126high-density lipoprotein particle remodeling (GO:0034375)3.02817098
127aspartate family amino acid metabolic process (GO:0009066)3.02717760
128dicarboxylic acid metabolic process (GO:0043648)3.02695811
129ubiquinone biosynthetic process (GO:0006744)3.01784840
130quinone biosynthetic process (GO:1901663)3.01784840
131DNA strand elongation involved in DNA replication (GO:0006271)3.00059601
132regulation of sequestering of triglyceride (GO:0010889)2.97581938
133antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.96938624
134cytochrome complex assembly (GO:0017004)2.96849328
135carnitine transmembrane transport (GO:1902603)2.96333329
136aerobic respiration (GO:0009060)2.95961158
137protein localization to mitochondrion (GO:0070585)2.95459021
138spliceosomal snRNP assembly (GO:0000387)2.94914501
139aldehyde catabolic process (GO:0046185)2.94859680
140cellular biogenic amine catabolic process (GO:0042402)2.94305179
141amine catabolic process (GO:0009310)2.94305179
142small molecule catabolic process (GO:0044282)2.94072650
143fusion of sperm to egg plasma membrane (GO:0007342)2.93685172
144pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.93672908
145establishment of protein localization to mitochondrion (GO:0072655)2.93453419
146mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93014486
147mitochondrial respiratory chain complex I assembly (GO:0032981)2.93014486
148NADH dehydrogenase complex assembly (GO:0010257)2.93014486
149regulation of acyl-CoA biosynthetic process (GO:0050812)2.89927898
150imidazole-containing compound metabolic process (GO:0052803)2.89360557
151proline metabolic process (GO:0006560)2.89210105
152sulfur amino acid metabolic process (GO:0000096)2.88704699
153regulation of ubiquitin-protein transferase activity (GO:0051438)2.88620282
154triglyceride homeostasis (GO:0070328)2.86987565
155organelle membrane fusion (GO:0090174)2.86858921
156telomere maintenance via recombination (GO:0000722)2.86812475
157DNA strand elongation (GO:0022616)2.84636295
158AMP metabolic process (GO:0046033)2.83737836
159establishment of integrated proviral latency (GO:0075713)2.83618935
160rRNA processing (GO:0006364)2.82587329
161deoxyribose phosphate metabolic process (GO:0019692)2.82176970
162pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.82053163
163establishment of viral latency (GO:0019043)2.81462327
164regulation of ligase activity (GO:0051340)2.81211663
165DNA catabolic process, exonucleolytic (GO:0000738)2.81080515
166* tRNA aminoacylation for protein translation (GO:0006418)2.78243714
167formation of translation preinitiation complex (GO:0001731)2.76638888
1682-deoxyribonucleotide metabolic process (GO:0009394)2.76193002
169deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.75179805
170folic acid-containing compound biosynthetic process (GO:0009396)2.74467955
171ribosome biogenesis (GO:0042254)2.73461703
172deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.72845998
173* amino acid activation (GO:0043038)2.72774137
174* tRNA aminoacylation (GO:0043039)2.72774137
175DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.71963155
176purine deoxyribonucleotide metabolic process (GO:0009151)2.71431621
177xenobiotic catabolic process (GO:0042178)2.71059822
178histone H2A acetylation (GO:0043968)2.70822630
179GTP biosynthetic process (GO:0006183)2.70240015
180pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.69831695
181purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.69813545
182iron-sulfur cluster assembly (GO:0016226)2.69627508
183metallo-sulfur cluster assembly (GO:0031163)2.69627508
184transcription-coupled nucleotide-excision repair (GO:0006283)2.69366303
185rRNA metabolic process (GO:0016072)2.69328164
186cellular component biogenesis (GO:0044085)2.67510881
187transcription from mitochondrial promoter (GO:0006390)2.66193991
188nucleotide-excision repair, DNA gap filling (GO:0006297)2.64268575
189regulation of cellular amine metabolic process (GO:0033238)2.64067681
190RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.62976421
191negative regulation of protein ubiquitination (GO:0031397)2.62506786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.94541930
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.99375023
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.51402939
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.20172674
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.01361241
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.51587666
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.32024250
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.15390755
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.05659709
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.95076045
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.78166648
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.68840899
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55623635
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.53962062
15ELK1_19687146_ChIP-ChIP_HELA_Human2.45111301
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.38067681
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.37123696
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.30387586
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.30156274
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20435434
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.19757553
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.15570195
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.09771841
24GATA1_22025678_ChIP-Seq_K562_Human2.01377432
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.00285192
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.85846206
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81429419
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80914561
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.78145852
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77328781
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77232404
32E2F7_22180533_ChIP-Seq_HELA_Human1.74003079
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65604236
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60910002
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.58803719
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56316528
37TTF2_22483619_ChIP-Seq_HELA_Human1.54980696
38IRF1_19129219_ChIP-ChIP_H3396_Human1.54650857
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53746819
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47748321
41* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44608444
42* CIITA_25753668_ChIP-Seq_RAJI_Human1.41350040
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41267415
44* FOXP3_21729870_ChIP-Seq_TREG_Human1.40455940
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38744557
46* YY1_21170310_ChIP-Seq_MESCs_Mouse1.38116303
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36778893
48* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35915252
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35630843
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33059699
51GABP_19822575_ChIP-Seq_HepG2_Human1.31456148
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30939967
53* DCP1A_22483619_ChIP-Seq_HELA_Human1.30089331
54BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29781888
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26392638
56* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25252532
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22900416
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22466223
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.21831430
60KDM5A_27292631_Chip-Seq_BREAST_Human1.21669503
61TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.21591642
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21344974
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21099220
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19952842
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19763626
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19386314
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18688051
68VDR_23849224_ChIP-Seq_CD4+_Human1.18522361
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17267837
70AR_21909140_ChIP-Seq_LNCAP_Human1.16943323
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16840453
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15230006
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14886405
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.12509326
75IRF8_22096565_ChIP-ChIP_GC-B_Human1.10193321
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10026945
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09286284
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08586219
79HTT_18923047_ChIP-ChIP_STHdh_Human1.06577958
80SPI1_23547873_ChIP-Seq_NB4_Human1.06540590
81ZNF274_21170338_ChIP-Seq_K562_Hela1.06013355
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05811369
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05671360
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04544775
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04501775
86RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03105641
87* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03002844
88E2F1_21310950_ChIP-Seq_MCF-7_Human1.02514970
89ELK1_22589737_ChIP-Seq_MCF10A_Human1.01857917
90ERG_20517297_ChIP-Seq_VCAP_Human1.01268810
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00633658
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98948475
93* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98900830
94SCL_19346495_ChIP-Seq_HPC-7_Human0.97992771
95XRN2_22483619_ChIP-Seq_HELA_Human0.96702661
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96619572
97TFEB_21752829_ChIP-Seq_HELA_Human0.96120639
98KAP1_22055183_ChIP-Seq_ESCs_Mouse0.95625211
99NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94331262
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93658022
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93116244
102MYB_26560356_Chip-Seq_TH2_Human0.92930713
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90373280
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89964820
105CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88678247
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87307644
107* SALL4_22934838_ChIP-ChIP_CD34+_Human0.87095456
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.86970106
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86811191
110* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.85515462
111GATA3_26560356_Chip-Seq_TH2_Human0.84914949
112SOX2_22085726_ChIP-Seq_NPCs_Mouse0.84059640
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83581118
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.82574101
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81760381
116FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.81158627
117YY1_22570637_ChIP-Seq_MALME-3M_Human0.80973018
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80964351
119AR_20517297_ChIP-Seq_VCAP_Human0.80887965
120LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80330182
121IGF1R_20145208_ChIP-Seq_DFB_Human0.80303166
122IRF8_21731497_ChIP-ChIP_J774_Mouse0.79555546
123MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.78787673
124CTCF_26484167_Chip-Seq_Bcells_Mouse0.78651123
125E2F4_17652178_ChIP-ChIP_JURKAT_Human0.78520455
126MYCN_18555785_ChIP-Seq_MESCs_Mouse0.77096505
127CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76931113
128MYC_18940864_ChIP-ChIP_HL60_Human0.76217313
129PADI4_21655091_ChIP-ChIP_MCF-7_Human0.75916295
130GATA4_21415370_ChIP-Seq_HL-1_Mouse0.75915270
131RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75738708
132GATA2_22383799_ChIP-Seq_G1ME_Mouse0.75370260
133PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74978089
134PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.74773829
135* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.74453319
136BCL6_27268052_Chip-Seq_Bcells_Human0.73278205
137EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.72512753
138* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.72406273
139ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.66097979
140EWS_26573619_Chip-Seq_HEK293_Human0.66075869

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.06534941
2MP0002139_abnormal_hepatobiliary_system6.00847763
3MP0005365_abnormal_bile_salt4.91602849
4MP0003806_abnormal_nucleotide_metabolis4.54413849
5MP0005085_abnormal_gallbladder_physiolo4.35986333
6MP0008058_abnormal_DNA_repair3.55253671
7MP0008875_abnormal_xenobiotic_pharmacok3.42545238
8MP0003646_muscle_fatigue3.38506823
9MP0000372_irregular_coat_pigmentation3.37686344
10MP0002837_dystrophic_cardiac_calcinosis3.24074228
11MP0005332_abnormal_amino_acid2.78580896
12MP0001835_abnormal_antigen_presentation2.78402019
13MP0006036_abnormal_mitochondrial_physio2.73639472
14MP0010329_abnormal_lipoprotein_level2.55866805
15MP0005464_abnormal_platelet_physiology2.53749633
16MP0003186_abnormal_redox_activity2.47276171
17MP0009840_abnormal_foam_cell2.44643764
18MP0004957_abnormal_blastocyst_morpholog2.43530966
19MP0008007_abnormal_cellular_replicative2.43045424
20MP0003252_abnormal_bile_duct2.29225673
21MP0005671_abnormal_response_to2.17147787
22MP0001666_abnormal_nutrient_absorption2.16855525
23MP0003786_premature_aging2.16425961
24MP0003111_abnormal_nucleus_morphology2.13475024
25MP0000465_gastrointestinal_hemorrhage2.12184041
26MP0003195_calcinosis2.10342493
27MP0003077_abnormal_cell_cycle2.06309697
28MP0001764_abnormal_homeostasis1.99983969
29MP0003656_abnormal_erythrocyte_physiolo1.97296601
30MP0005083_abnormal_biliary_tract1.94966216
31MP0006072_abnormal_retinal_apoptosis1.93153562
32MP0005075_abnormal_melanosome_morpholog1.92213775
33MP0003191_abnormal_cellular_cholesterol1.90190348
34MP0005319_abnormal_enzyme/_coenzyme1.84033875
35MP0002148_abnormal_hypersensitivity_rea1.82330326
36MP0005670_abnormal_white_adipose1.81935657
37MP0003763_abnormal_thymus_physiology1.79544959
38MP0008932_abnormal_embryonic_tissue1.74473676
39MP0000609_abnormal_liver_physiology1.74316134
40MP0002118_abnormal_lipid_homeostasis1.70942563
41MP0004147_increased_porphyrin_level1.69712961
42MP0009643_abnormal_urine_homeostasis1.69290061
43MP0004215_abnormal_myocardial_fiber1.68167832
44MP0005584_abnormal_enzyme/coenzyme_acti1.61396050
45MP0004019_abnormal_vitamin_homeostasis1.52550659
46MP0005636_abnormal_mineral_homeostasis1.50226174
47MP0005410_abnormal_fertilization1.42380854
48MP0005330_cardiomyopathy1.41359044
49MP0005451_abnormal_body_composition1.41177245
50MP0005266_abnormal_metabolism1.37643242
51MP0004043_abnormal_pH_regulation1.35684358
52MP0001800_abnormal_humoral_immune1.34899125
53MP0008872_abnormal_physiological_respon1.34564215
54MP0004084_abnormal_cardiac_muscle1.33761892
55MP0002166_altered_tumor_susceptibility1.33486890
56MP0000689_abnormal_spleen_morphology1.33192230
57MP0006035_abnormal_mitochondrial_morpho1.32295494
58MP0004130_abnormal_muscle_cell1.29420219
59MP0008260_abnormal_autophagy1.28925137
60MP0008057_abnormal_DNA_replication1.27578412
61MP0002398_abnormal_bone_marrow1.27166049
62MP0001853_heart_inflammation1.27011962
63MP0000749_muscle_degeneration1.26330049
64MP0000751_myopathy1.26288986
65MP0002019_abnormal_tumor_incidence1.24179271
66MP0002452_abnormal_antigen_presenting1.23185469
67MP0009785_altered_susceptibility_to1.22141334
68MP0005666_abnormal_adipose_tissue1.21631634
69MP0002006_tumorigenesis1.20916318
70MP0002723_abnormal_immune_serum1.20715654
71MP0005058_abnormal_lysosome_morphology1.20403515
72MP0004036_abnormal_muscle_relaxation1.17528126
73MP0009697_abnormal_copulation1.17395599
74MP0005000_abnormal_immune_tolerance1.17363820
75MP0002420_abnormal_adaptive_immunity1.15388331
76MP0003868_abnormal_feces_composition1.14706036
77MP0001819_abnormal_immune_cell1.14569336
78MP0002722_abnormal_immune_system1.14327275
79MP0002102_abnormal_ear_morphology1.14193902
80MP0003693_abnormal_embryo_hatching1.10630269
81MP0002396_abnormal_hematopoietic_system1.10184317
82MP0002429_abnormal_blood_cell1.06940627
83MP0002095_abnormal_skin_pigmentation1.06296919
84MP0005395_other_phenotype1.03994577
85MP0003011_delayed_dark_adaptation1.03840351
86MP0000598_abnormal_liver_morphology1.03750243
87MP0003866_abnormal_defecation1.02181642
88MP0002138_abnormal_hepatobiliary_system1.02173218
89MP0005253_abnormal_eye_physiology1.01918938
90MP0005376_homeostasis/metabolism_phenot1.01216285
91MP0002078_abnormal_glucose_homeostasis1.00868000
92MP0001765_abnormal_ion_homeostasis1.00170204
93MP0009333_abnormal_splenocyte_physiolog0.99492295
94MP0002269_muscular_atrophy0.98835737
95MP0002132_abnormal_respiratory_system0.97184084
96MP0001661_extended_life_span0.96901531
97MP0000716_abnormal_immune_system0.96799134
98MP0005397_hematopoietic_system_phenotyp0.95535995
99MP0001545_abnormal_hematopoietic_system0.95535995
100MP0001873_stomach_inflammation0.95476019
101MP0008873_increased_physiological_sensi0.95169106
102MP0008469_abnormal_protein_level0.93371442
103MP0000313_abnormal_cell_death0.93009422
104MP0003221_abnormal_cardiomyocyte_apopto0.89623221
105MP0000604_amyloidosis0.89464436
106MP0002405_respiratory_system_inflammati0.88998193
107MP0009642_abnormal_blood_homeostasis0.88990237
108MP0000490_abnormal_crypts_of0.88885812
109MP0000703_abnormal_thymus_morphology0.88878803
110MP0005647_abnormal_sex_gland0.88075134
111MP0009763_increased_sensitivity_to0.86129334
112MP0001790_abnormal_immune_system0.85157187
113MP0005387_immune_system_phenotype0.85157187
114MP0000015_abnormal_ear_pigmentation0.85117066
115MP0005535_abnormal_body_temperature0.83767898
116MP0005646_abnormal_pituitary_gland0.83617962
117MP0002972_abnormal_cardiac_muscle0.82809752
118MP0003718_maternal_effect0.82477632
119MP0000685_abnormal_immune_system0.81736411
120MP0001544_abnormal_cardiovascular_syste0.81097400
121MP0005385_cardiovascular_system_phenoty0.81097400
122MP0010155_abnormal_intestine_physiology0.81045796
123MP0009764_decreased_sensitivity_to0.79689147
124MP0001845_abnormal_inflammatory_respons0.79139127
125MP0005025_abnormal_response_to0.78958879
126MP0002971_abnormal_brown_adipose0.78915613
127MP0005220_abnormal_exocrine_pancreas0.78157024
128MP0003329_amyloid_beta_deposits0.76519486
129MP0001929_abnormal_gametogenesis0.76193582
130MP0005165_increased_susceptibility_to0.76113388
131MP0004087_abnormal_muscle_fiber0.74349991
132MP0003137_abnormal_impulse_conducting0.74063444
133MP0008789_abnormal_olfactory_epithelium0.73368613
134MP0005551_abnormal_eye_electrophysiolog0.72159119
135MP0000343_altered_response_to0.72066207
136MP0000350_abnormal_cell_proliferation0.69143951
137MP0001756_abnormal_urination0.68740041
138MP0001905_abnormal_dopamine_level0.67713981
139MP0004808_abnormal_hematopoietic_stem0.67299377
140MP0008995_early_reproductive_senescence0.67003575
141MP0003943_abnormal_hepatobiliary_system0.65548192
142MP0006276_abnormal_autonomic_nervous0.65494402
143MP0000230_abnormal_systemic_arterial0.65164242
144MP0005379_endocrine/exocrine_gland_phen0.64789663
145MP0010094_abnormal_chromosome_stability0.62503514
146MP0010630_abnormal_cardiac_muscle0.62314524
147MP0006138_congestive_heart_failure0.60031374
148MP0000358_abnormal_cell_content/0.60001984
149MP0005620_abnormal_muscle_contractility0.59961107
150MP0001730_embryonic_growth_arrest0.59767503
151MP0005408_hypopigmentation0.58922363
152MP0002106_abnormal_muscle_physiology0.58771255
153MP0002136_abnormal_kidney_physiology0.58035035
154MP0002332_abnormal_exercise_endurance0.57559151
155MP0005084_abnormal_gallbladder_morpholo0.57031438
156MP0002254_reproductive_system_inflammat0.55548930
157MP0008775_abnormal_heart_ventricle0.55152166
158MP0005334_abnormal_fat_pad0.54672398
159MP0003953_abnormal_hormone_level0.54130358
160MP0002970_abnormal_white_adipose0.53629349
161MP0003698_abnormal_male_reproductive0.49876767
162MP0001663_abnormal_digestive_system0.49697279
163MP0005448_abnormal_energy_balance0.49362781
164MP0009115_abnormal_fat_cell0.48537032
165MP0008877_abnormal_DNA_methylation0.47949886

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of fatty-acid metabolism (HP:0004359)4.51940954
2Hyperglycinuria (HP:0003108)4.46304143
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.39327894
4Hepatic necrosis (HP:0002605)4.35800226
5Hypoglycemic coma (HP:0001325)4.22110234
6Abnormality of dicarboxylic acid metabolism (HP:0010995)4.21392319
7Dicarboxylic aciduria (HP:0003215)4.21392319
8Hyperammonemia (HP:0001987)4.20695712
9Ketosis (HP:0001946)4.15471661
10Acute encephalopathy (HP:0006846)4.14638240
11Intrahepatic cholestasis (HP:0001406)4.02658212
12Abnormality of serine family amino acid metabolism (HP:0010894)4.02403723
13Abnormality of glycine metabolism (HP:0010895)4.02403723
14Cerebral edema (HP:0002181)3.92219460
15Abnormal mitochondria in muscle tissue (HP:0008316)3.85101066
16Hyperglycinemia (HP:0002154)3.83266857
17Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.81210188
18Hepatocellular necrosis (HP:0001404)3.81050112
19Acute necrotizing encephalopathy (HP:0006965)3.79050755
20Ketoacidosis (HP:0001993)3.74469734
21Generalized aminoaciduria (HP:0002909)3.61518236
22Hypobetalipoproteinemia (HP:0003563)3.61488959
23Microvesicular hepatic steatosis (HP:0001414)3.54405780
24Increased muscle lipid content (HP:0009058)3.48857643
25Increased CSF lactate (HP:0002490)3.44893197
26Mitochondrial inheritance (HP:0001427)3.44751209
27Type I transferrin isoform profile (HP:0003642)3.41490671
28* Lactic acidosis (HP:0003128)3.37650204
29Lethargy (HP:0001254)3.35785139
30Lipid accumulation in hepatocytes (HP:0006561)3.24317638
31Xanthomatosis (HP:0000991)3.22419451
32Myoglobinuria (HP:0002913)3.21461369
33Abnormality of monocarboxylic acid metabolism (HP:0010996)3.20189674
34Increased intramyocellular lipid droplets (HP:0012240)3.19026254
35Metabolic acidosis (HP:0001942)3.14045239
36Abnormal protein glycosylation (HP:0012346)3.06618019
37Abnormal glycosylation (HP:0012345)3.06618019
38Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.06618019
39Abnormal protein N-linked glycosylation (HP:0012347)3.06618019
40Reduced antithrombin III activity (HP:0001976)3.06102276
41Progressive macrocephaly (HP:0004481)3.01106729
42Abnormality of serum amino acid levels (HP:0003112)2.98601760
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.97115677
44Deep venous thrombosis (HP:0002625)2.96864180
45Prolonged partial thromboplastin time (HP:0003645)2.96738150
46Hyperlipoproteinemia (HP:0010980)2.95494225
47Rhabdomyolysis (HP:0003201)2.95428151
48Petechiae (HP:0000967)2.93107397
49Hyperbilirubinemia (HP:0002904)2.92677600
50Abnormality of the prostate (HP:0008775)2.92577878
51Palpitations (HP:0001962)2.87093465
52Methylmalonic aciduria (HP:0012120)2.84938413
53Hypomagnesemia (HP:0002917)2.84615196
54Abnormality of methionine metabolism (HP:0010901)2.83805754
55Hypolipoproteinemia (HP:0010981)2.83718497
56Dyschromatopsia (HP:0007641)2.81476447
57Increased hepatocellular lipid droplets (HP:0006565)2.80594650
58Abnormal number of erythroid precursors (HP:0012131)2.80085960
59Proximal tubulopathy (HP:0000114)2.79791553
60* Increased serum lactate (HP:0002151)2.76398468
61Decreased activity of mitochondrial respiratory chain (HP:0008972)2.76202520
62Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.76202520
63Prostate neoplasm (HP:0100787)2.74894165
64Abnormality of glycolysis (HP:0004366)2.72443390
65Increased serum pyruvate (HP:0003542)2.72443390
66Aplastic anemia (HP:0001915)2.72029973
67Abnormality of urine glucose concentration (HP:0011016)2.71695007
68Glycosuria (HP:0003076)2.71695007
69Vomiting (HP:0002013)2.63305212
70Abnormality of sulfur amino acid metabolism (HP:0004339)2.62808049
71Abnormality of glutamine family amino acid metabolism (HP:0010902)2.62373192
72Gout (HP:0001997)2.61855934
73CNS demyelination (HP:0007305)2.56841900
74Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.56143070
75Fat malabsorption (HP:0002630)2.49249629
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49209755
77Abnormality of magnesium homeostasis (HP:0004921)2.48637043
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.47413233
79Hypoalphalipoproteinemia (HP:0003233)2.44843488
80Respiratory failure (HP:0002878)2.43109660
81Pancytopenia (HP:0001876)2.42377387
82Abnormality of cells of the erythroid lineage (HP:0012130)2.40929286
83Late onset (HP:0003584)2.40905483
84Exercise intolerance (HP:0003546)2.38996174
85Molar tooth sign on MRI (HP:0002419)2.38873451
86Abnormality of midbrain morphology (HP:0002418)2.38873451
87Delayed CNS myelination (HP:0002188)2.37104196
88Abnormal pupillary function (HP:0007686)2.36614933
89Respiratory difficulties (HP:0002880)2.36483102
90Renal Fanconi syndrome (HP:0001994)2.36386842
91Abnormal gallbladder morphology (HP:0012437)2.35642693
92Degeneration of anterior horn cells (HP:0002398)2.35597630
93Abnormality of the anterior horn cell (HP:0006802)2.35597630
94Type 2 muscle fiber atrophy (HP:0003554)2.35016356
95Renal cortical cysts (HP:0000803)2.34093152
96Abnormal gallbladder physiology (HP:0012438)2.32628802
97Cholecystitis (HP:0001082)2.32628802
98Abnormality of alanine metabolism (HP:0010916)2.32309284
99Hyperalaninemia (HP:0003348)2.32309284
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32309284
101Nausea (HP:0002018)2.32261097
102Exertional dyspnea (HP:0002875)2.31966715
103Optic disc pallor (HP:0000543)2.28458338
104Colon cancer (HP:0003003)2.28012423
105Cholelithiasis (HP:0001081)2.27970021
106Abolished electroretinogram (ERG) (HP:0000550)2.27328342
107Oral leukoplakia (HP:0002745)2.25693691
1083-Methylglutaconic aciduria (HP:0003535)2.25685644
109Abnormality of purine metabolism (HP:0004352)2.20862335
110Methylmalonic acidemia (HP:0002912)2.19781276
111Abnormality of nucleobase metabolism (HP:0010932)2.16778776
112Ragged-red muscle fibers (HP:0003200)2.13629328
113Leukodystrophy (HP:0002415)2.11740873
114Hypoplasia of the thymus (HP:0000778)2.09466310
115Joint hemorrhage (HP:0005261)2.09374154
116Abnormality of pyrimidine metabolism (HP:0004353)2.08611658
117Ventricular tachycardia (HP:0004756)2.07048119
118Hypercholesterolemia (HP:0003124)2.07026375
119Autoimmune hemolytic anemia (HP:0001890)2.06569604
120Asymmetric septal hypertrophy (HP:0001670)2.05609795
121Hyperinsulinemic hypoglycemia (HP:0000825)2.04259333
122IgM deficiency (HP:0002850)2.02951767
123Hypoglycemic seizures (HP:0002173)2.02949104
124Muscle fiber atrophy (HP:0100295)2.02910866
125Abnormality of the intrinsic pathway (HP:0010989)2.01289882
126Prolonged bleeding time (HP:0003010)2.00708359
127Steatorrhea (HP:0002570)1.99394987
128Exercise-induced myalgia (HP:0003738)1.96235792
129Abnormality of the heme biosynthetic pathway (HP:0010472)1.96074304
130Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96033332
131Stomach cancer (HP:0012126)1.93560564
132Pancreatic cysts (HP:0001737)1.92792613
133Abnormality of renal resorption (HP:0011038)1.92580714
134Poor head control (HP:0002421)1.92567979
135Hyperuricemia (HP:0002149)1.92523369
136Increased purine levels (HP:0004368)1.92523369
137Abnormality of the common coagulation pathway (HP:0010990)1.92193197
138Conjugated hyperbilirubinemia (HP:0002908)1.90661635
139Abnormality of T cell physiology (HP:0011840)1.89657510
140Panhypogammaglobulinemia (HP:0003139)1.89256586
141True hermaphroditism (HP:0010459)1.87459994
142Stomatitis (HP:0010280)1.87040383
143Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.86375424
144Pancreatic fibrosis (HP:0100732)1.85556917
145Elevated erythrocyte sedimentation rate (HP:0003565)1.84309631
146IgG deficiency (HP:0004315)1.82357597
147Progressive microcephaly (HP:0000253)1.81749239
148Paralysis (HP:0003470)1.81289005
149Hypoplasia of the pons (HP:0012110)1.81123263
150Pulmonary fibrosis (HP:0002206)1.80366488
151Cellular immunodeficiency (HP:0005374)1.80005165
152Neutropenia (HP:0001875)1.78132644
153Opisthotonus (HP:0002179)1.76988983
154Abnormality of T cells (HP:0002843)1.76370930
155Rough bone trabeculation (HP:0100670)1.76278170
156X-linked dominant inheritance (HP:0001423)1.74690821
157Congenital, generalized hypertrichosis (HP:0004540)1.74067082
158Abnormality of B cell number (HP:0010975)1.73194161
159Abnormality of the preputium (HP:0100587)1.70773100

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.49437688
2PDK44.73193118
3PDK34.73193118
4ZAK4.20340115
5VRK24.01232256
6LMTK23.42674176
7STK163.01801445
8PDK22.69589241
9NUAK12.65752647
10BUB12.61065497
11MAP3K122.23290130
12WNK32.15471561
13TXK2.03963518
14MAP4K22.03013845
15ERN12.02555897
16STK38L2.01740012
17TAOK31.92816727
18PBK1.89710991
19ACVR1B1.79466519
20SRPK11.78798711
21TSSK61.75095617
22IRAK31.72480117
23MUSK1.69924984
24NEK11.69894186
25MYLK1.63564087
26SCYL21.61988070
27EIF2AK11.61365074
28CDC71.58474596
29KIT1.53633888
30PINK11.48101983
31MAPK111.46702724
32FLT31.42798243
33BMPR1B1.42633228
34PLK31.41834618
35TESK21.40597729
36CCNB11.40275041
37MAP2K31.36932962
38TEC1.36671035
39WNK41.36356691
40SIK11.29979676
41FER1.27276504
42INSRR1.24538636
43TTN1.22405668
44CDK191.21997113
45PHKG21.17768212
46PHKG11.17768212
47MAP4K11.17658638
48TYK21.17519312
49VRK11.13910598
50STK241.12660660
51OBSCN1.11861786
52PLK41.05601206
53PIM21.04132884
54MAP3K31.03509168
55ERBB41.03244912
56ARAF1.02240336
57FGFR41.01919290
58MAP3K61.01629173
59EIF2AK30.99928657
60MAPKAPK30.97035319
61FES0.93716489
62GRK10.92436814
63MAP3K110.92195637
64TLK10.90289607
65BRAF0.89818218
66MKNK10.88656143
67MAPK150.87923622
68TIE10.84391013
69KDR0.83479815
70RPS6KA50.79895343
71TRIM280.77620297
72PKN20.76276768
73ABL20.75698511
74EEF2K0.74498474
75WEE10.73050746
76NME10.72449631
77TBK10.71598098
78MAP2K60.71418477
79EIF2AK20.70472838
80NME20.69700193
81BTK0.69532400
82TTK0.68990313
83CSNK1G10.67711553
84IKBKB0.65700258
85MAPK120.65629415
86NEK20.65159228
87TRIB30.64607045
88BRSK20.63569805
89PASK0.62548100
90OXSR10.61372642
91GRK60.60988296
92TAF10.59348688
93CSNK1G30.57521427
94STK40.57048636
95MAP3K50.55557890
96DYRK30.54539766
97IKBKE0.54044096
98MAPK40.53772135
99PRKAA10.52844841
100AURKB0.52730254
101MKNK20.52407941
102PRKAA20.51385198
103ADRBK20.50722357
104MARK30.49456428
105TNIK0.49097546
106SIK30.48649003
107CDK40.47220131
108TESK10.46988785
109PIK3CG0.45888553
110MAP3K130.45588350
111NLK0.45040917
112IRAK10.43826307
113JAK20.43700525
114BRSK10.43462129
115DAPK10.42763585
116LRRK20.42171622
117TAOK20.41143650
118CSNK2A20.41009503
119IRAK40.40077055
120ITK0.39867589
121PRKCQ0.39649467
122PLK10.39207798
123TGFBR10.38660098
124PRKCI0.38486768
125PAK10.37976319
126CSF1R0.37864468
127CSNK2A10.37814038
128AURKA0.37678935
129DYRK20.36248033
130MATK0.36158756
131BMPR20.35724862
132CHEK10.35120969
133ILK0.34252278
134PIM10.33552937
135SYK0.32618368
136GRK50.31797453
137PRKG20.29288462
138MST40.28604087
139ZAP700.28424564
140ATR0.28327793
141JAK30.27426772
142PRKACG0.27244382
143STK100.25902622
144LYN0.24573998
145RPS6KB20.24272212
146CHEK20.23947909
147CDK80.23795159
148STK390.23522707

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.20771644
2Propanoate metabolism_Homo sapiens_hsa006403.14620455
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.03737630
4Fatty acid degradation_Homo sapiens_hsa000713.02143985
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.72947059
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.71480501
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.62865965
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.59158383
9Fatty acid metabolism_Homo sapiens_hsa012122.34373704
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33995957
11Pyruvate metabolism_Homo sapiens_hsa006202.32347685
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29356379
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.20720523
14Butanoate metabolism_Homo sapiens_hsa006502.18662828
15Peroxisome_Homo sapiens_hsa041462.17805824
16Carbon metabolism_Homo sapiens_hsa012002.12838878
17Tryptophan metabolism_Homo sapiens_hsa003802.10141357
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.08067991
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.99200128
20Asthma_Homo sapiens_hsa053101.92775309
21Fatty acid elongation_Homo sapiens_hsa000621.86508375
22Oxidative phosphorylation_Homo sapiens_hsa001901.84866958
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74953312
24Selenocompound metabolism_Homo sapiens_hsa004501.72888158
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.70203200
26Arginine biosynthesis_Homo sapiens_hsa002201.69229176
27Parkinsons disease_Homo sapiens_hsa050121.66944807
28Spliceosome_Homo sapiens_hsa030401.66838092
29Nitrogen metabolism_Homo sapiens_hsa009101.66114124
30PPAR signaling pathway_Homo sapiens_hsa033201.64486442
31Biosynthesis of amino acids_Homo sapiens_hsa012301.63099593
32Sulfur metabolism_Homo sapiens_hsa009201.62110560
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.59510310
34Allograft rejection_Homo sapiens_hsa053301.59101224
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.58171241
36Autoimmune thyroid disease_Homo sapiens_hsa053201.53347231
37Systemic lupus erythematosus_Homo sapiens_hsa053221.52156833
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.49396544
39Graft-versus-host disease_Homo sapiens_hsa053321.49178293
40RNA degradation_Homo sapiens_hsa030181.44119156
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.42623409
42Fanconi anemia pathway_Homo sapiens_hsa034601.41049251
43beta-Alanine metabolism_Homo sapiens_hsa004101.41010942
44Pentose phosphate pathway_Homo sapiens_hsa000301.35953519
45RNA transport_Homo sapiens_hsa030131.31959116
46Histidine metabolism_Homo sapiens_hsa003401.29325860
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28178648
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.26831005
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.24978874
50Folate biosynthesis_Homo sapiens_hsa007901.23813762
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22977815
52Chemical carcinogenesis_Homo sapiens_hsa052041.22116241
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21930759
54Starch and sucrose metabolism_Homo sapiens_hsa005001.20723259
55Complement and coagulation cascades_Homo sapiens_hsa046101.20301096
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.20228666
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.19481046
58Antigen processing and presentation_Homo sapiens_hsa046121.17007376
59Type I diabetes mellitus_Homo sapiens_hsa049401.11526167
60Huntingtons disease_Homo sapiens_hsa050161.11280097
61Sulfur relay system_Homo sapiens_hsa041221.11086356
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09856907
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08637696
64Arginine and proline metabolism_Homo sapiens_hsa003301.08278846
65Basal transcription factors_Homo sapiens_hsa030221.07568175
66Fructose and mannose metabolism_Homo sapiens_hsa000511.06760344
67Primary immunodeficiency_Homo sapiens_hsa053401.06253619
68Alzheimers disease_Homo sapiens_hsa050101.06023199
69Phenylalanine metabolism_Homo sapiens_hsa003601.02992385
70Vitamin B6 metabolism_Homo sapiens_hsa007501.02399999
71Caffeine metabolism_Homo sapiens_hsa002321.02352984
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02277206
73Maturity onset diabetes of the young_Homo sapiens_hsa049501.02096726
74Glutathione metabolism_Homo sapiens_hsa004800.98011289
75DNA replication_Homo sapiens_hsa030300.97624901
76Fatty acid biosynthesis_Homo sapiens_hsa000610.94561829
77Fat digestion and absorption_Homo sapiens_hsa049750.93934624
78Tyrosine metabolism_Homo sapiens_hsa003500.93867562
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.92765741
80Metabolic pathways_Homo sapiens_hsa011000.88616579
81Proteasome_Homo sapiens_hsa030500.87466288
82One carbon pool by folate_Homo sapiens_hsa006700.86289977
83Cell cycle_Homo sapiens_hsa041100.83944226
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82952014
85Galactose metabolism_Homo sapiens_hsa000520.82352067
86Retinol metabolism_Homo sapiens_hsa008300.82070705
87Hematopoietic cell lineage_Homo sapiens_hsa046400.81974881
88Bile secretion_Homo sapiens_hsa049760.81711490
89Viral myocarditis_Homo sapiens_hsa054160.80927533
90Pyrimidine metabolism_Homo sapiens_hsa002400.77927086
91Rheumatoid arthritis_Homo sapiens_hsa053230.73803413
92Glycerolipid metabolism_Homo sapiens_hsa005610.72423874
93ABC transporters_Homo sapiens_hsa020100.71158511
94Cardiac muscle contraction_Homo sapiens_hsa042600.70402629
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69583445
96Base excision repair_Homo sapiens_hsa034100.67659367
97N-Glycan biosynthesis_Homo sapiens_hsa005100.67628121
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63522468
99Protein export_Homo sapiens_hsa030600.58587447
100Mismatch repair_Homo sapiens_hsa034300.58505020
101Epstein-Barr virus infection_Homo sapiens_hsa051690.58462701
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.55849485
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55573925
104RNA polymerase_Homo sapiens_hsa030200.51634679
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50335041
106Phototransduction_Homo sapiens_hsa047440.49293408
107Herpes simplex infection_Homo sapiens_hsa051680.45900676
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45841818
109Vitamin digestion and absorption_Homo sapiens_hsa049770.45764444
110Ribosome_Homo sapiens_hsa030100.45113057
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44921889
112Linoleic acid metabolism_Homo sapiens_hsa005910.42333592
113Purine metabolism_Homo sapiens_hsa002300.42030869
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41988748
115Lysine degradation_Homo sapiens_hsa003100.40991107
116Collecting duct acid secretion_Homo sapiens_hsa049660.38173002
117Staphylococcus aureus infection_Homo sapiens_hsa051500.37718126
118p53 signaling pathway_Homo sapiens_hsa041150.35903176
119Steroid biosynthesis_Homo sapiens_hsa001000.33841431
120Homologous recombination_Homo sapiens_hsa034400.29623987
121Nucleotide excision repair_Homo sapiens_hsa034200.29129885
122Glucagon signaling pathway_Homo sapiens_hsa049220.28275188
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.27279674
124* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27026655
125Other glycan degradation_Homo sapiens_hsa005110.22451069
126Non-homologous end-joining_Homo sapiens_hsa034500.21007440
127Renin-angiotensin system_Homo sapiens_hsa046140.17946886
128Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17524998
129Arachidonic acid metabolism_Homo sapiens_hsa005900.15291545
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.14120423
131Regulation of autophagy_Homo sapiens_hsa041400.11910670
132Insulin resistance_Homo sapiens_hsa049310.11865775

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