FASLG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)9.37717655
2positive regulation of fibroblast migration (GO:0010763)9.17469324
3heart field specification (GO:0003128)9.14723846
4secondary heart field specification (GO:0003139)9.14723846
5cell migration involved in heart development (GO:0060973)9.11131341
6negative regulation of cell fate specification (GO:0009996)8.99517423
7cytidine deamination (GO:0009972)8.62709764
8cytidine metabolic process (GO:0046087)8.62709764
9cytidine catabolic process (GO:0006216)8.62709764
10pyrimidine ribonucleoside catabolic process (GO:0046133)7.66751513
11growth hormone receptor signaling pathway (GO:0060396)7.46170396
12positive regulation of cell fate commitment (GO:0010455)7.31591811
13cardiac ventricle formation (GO:0003211)7.29394856
14positive regulation of interleukin-17 production (GO:0032740)6.83499374
15cardiac chamber formation (GO:0003207)6.68840675
16cellular response to growth hormone stimulus (GO:0071378)6.64259353
17negative regulation of cell fate commitment (GO:0010454)6.24260604
18positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)6.00747690
19regulation of metalloenzyme activity (GO:0048552)5.92131622
20specification of organ identity (GO:0010092)5.79226723
21regulation of mesoderm development (GO:2000380)5.58339744
22cell migration involved in gastrulation (GO:0042074)5.56401053
23sleep (GO:0030431)5.55471945
24regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)5.53683853
25positive regulation of extracellular matrix organization (GO:1903055)5.46694352
26T-helper 1 type immune response (GO:0042088)5.39159725
27positive regulation of alpha-beta T cell proliferation (GO:0046641)4.68608826
28positive regulation of defense response to virus by host (GO:0002230)4.64220913
29regulation of cell fate specification (GO:0042659)4.47429626
30endothelial cell differentiation (GO:0045446)4.36305049
31positive regulation of lamellipodium organization (GO:1902745)4.35568411
32somite rostral/caudal axis specification (GO:0032525)4.33061025
33intra-S DNA damage checkpoint (GO:0031573)4.30410594
34regulation of alpha-beta T cell proliferation (GO:0046640)4.28422048
35positive regulation of calcium-mediated signaling (GO:0050850)4.21854820
36regulation of fibroblast migration (GO:0010762)4.16566658
37cytokine biosynthetic process (GO:0042089)4.15439000
38positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)4.14215462
39hydrogen peroxide biosynthetic process (GO:0050665)4.12921763
40positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)4.10278166
41regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)4.10278166
42regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.03349697
43negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.96581116
44regulation of interleukin-17 production (GO:0032660)3.92581155
45G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.92247974
46regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.86046969
47positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.86046969
48L-fucose metabolic process (GO:0042354)3.81804279
49L-fucose catabolic process (GO:0042355)3.81804279
50fucose catabolic process (GO:0019317)3.81804279
51positive regulation of Notch signaling pathway (GO:0045747)3.78382118
52respiratory system process (GO:0003016)3.74583074
53reactive oxygen species biosynthetic process (GO:1903409)3.72832002
54signal transduction involved in regulation of gene expression (GO:0023019)3.70299642
55negative regulation of osteoclast differentiation (GO:0045671)3.62812259
56response to growth hormone (GO:0060416)3.54685063
57pyrimidine nucleoside catabolic process (GO:0046135)3.50222228
58activated T cell proliferation (GO:0050798)3.47099316
59cytokine metabolic process (GO:0042107)3.44835942
60mesodermal cell differentiation (GO:0048333)3.44083427
61positive regulation of activated T cell proliferation (GO:0042104)3.40243819
62insulin-like growth factor receptor signaling pathway (GO:0048009)3.38802135
63positive regulation of natural killer cell activation (GO:0032816)3.32100850
64positive regulation of gamma-delta T cell activation (GO:0046645)3.30980079
65regulation of substrate adhesion-dependent cell spreading (GO:1900024)3.20547123
66regulation of calcium-mediated signaling (GO:0050848)3.18580275
67regulation of regulatory T cell differentiation (GO:0045589)3.18496144
68lipopolysaccharide-mediated signaling pathway (GO:0031663)3.17234817
69negative regulation of telomerase activity (GO:0051974)3.14933344
70negative regulation of embryonic development (GO:0045992)3.09020746
71Golgi transport vesicle coating (GO:0048200)3.08455679
72COPI coating of Golgi vesicle (GO:0048205)3.08455679
73positive regulation of mRNA catabolic process (GO:0061014)3.07287586
74positive regulation of mRNA 3-end processing (GO:0031442)3.06066599
75positive regulation of establishment of protein localization to plasma membrane (GO:0090004)3.05299117
76purinergic nucleotide receptor signaling pathway (GO:0035590)3.04453863
77DNA replication checkpoint (GO:0000076)3.03980344
78response to nerve growth factor (GO:1990089)3.03296015
79cellular response to nerve growth factor stimulus (GO:1990090)3.03296015
80positive regulation of striated muscle cell differentiation (GO:0051155)3.00851089
81negative regulation of viral genome replication (GO:0045071)2.98930160
82adaptation of signaling pathway (GO:0023058)2.98469277
83regulation of telomere maintenance via telomerase (GO:0032210)2.92996639
84positive regulation of protein localization to plasma membrane (GO:1903078)2.92914003
85cardiac chamber morphogenesis (GO:0003206)2.91922178
86tolerance induction (GO:0002507)2.91907757
87filopodium assembly (GO:0046847)2.91845869
88regulation of extracellular matrix organization (GO:1903053)2.90374880
89positive regulation of NF-kappaB import into nucleus (GO:0042346)2.88805919
90positive regulation of B cell differentiation (GO:0045579)2.86734253
91cellular response to interleukin-15 (GO:0071350)2.86570967
92DNA demethylation (GO:0080111)2.83441035
93leukocyte aggregation (GO:0070486)2.82559119
94defense response to fungus (GO:0050832)2.81921770
95alkaloid metabolic process (GO:0009820)2.81192653
96regulation of gamma-delta T cell differentiation (GO:0045586)2.80432017
97regulation of natural killer cell activation (GO:0032814)2.77916594
98positive regulation of natural killer cell mediated immunity (GO:0002717)2.77282219
99regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:004509110.3682473
100regulation of Wnt signaling pathway involved in heart development (GO:0003307)10.3671223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse9.98580094
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.34812122
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.22731085
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.40851183
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.02396488
6* RUNX_20019798_ChIP-Seq_JUKART_Human3.59760933
7FLI1_27457419_Chip-Seq_LIVER_Mouse3.13788170
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.09496462
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.03547564
10ZNF263_19887448_ChIP-Seq_K562_Human2.61159702
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.45004138
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.30008650
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.16973757
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06601217
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.94165709
16TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.93314415
17GATA3_27048872_Chip-Seq_THYMUS_Human1.92480556
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87324705
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.84712370
20* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.82009958
21MYB_26560356_Chip-Seq_TH2_Human1.78341046
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.77497207
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.72129856
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.69199133
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.68507515
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.65957339
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.57298475
28LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.56456310
29GATA3_26560356_Chip-Seq_TH2_Human1.53340338
30PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.51505125
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.42730468
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38580243
33PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.37328218
34BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.35450776
35* TAF2_19829295_ChIP-Seq_ESCs_Human1.34790703
36PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.33385103
37P53_22127205_ChIP-Seq_FIBROBLAST_Human1.27821730
38GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27145303
39P53_21459846_ChIP-Seq_SAOS-2_Human1.26671169
40SCL_19346495_ChIP-Seq_HPC-7_Human1.25787481
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22327955
42GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.18308002
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12160516
44* GATA3_26560356_Chip-Seq_TH1_Human1.11676039
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.08523383
46RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06237370
47* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05576043
48FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05381087
49PRDM14_20953172_ChIP-Seq_ESCs_Human1.04328953
50OCT4_20526341_ChIP-Seq_ESCs_Human1.00446100
51CTCF_20526341_ChIP-Seq_ESCs_Human0.98217631
52* GATA3_21878914_ChIP-Seq_MCF-7_Human0.96436054
53EZH2_27294783_Chip-Seq_NPCs_Mouse0.94328032
54GATA3_21867929_ChIP-Seq_TH1_Mouse0.94064079
55ERG_21242973_ChIP-ChIP_JURKAT_Human0.93238456
56CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92215247
57ARNT_22903824_ChIP-Seq_MCF-7_Human0.92141970
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91885733
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91157866
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90426082
61SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89986992
62FOXH1_21741376_ChIP-Seq_EPCs_Human0.88912241
63* MYB_26560356_Chip-Seq_TH1_Human0.88842885
64IRF8_21731497_ChIP-ChIP_J774_Mouse0.87882933
65STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.87466013
66* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86089493
67OCT1_27270436_Chip-Seq_PROSTATE_Human0.86052082
68RUNX1_27457419_Chip-Seq_LIVER_Mouse0.85411966
69PU_27001747_Chip-Seq_BMDM_Mouse0.84964041
70STAT3_18555785_Chip-Seq_ESCs_Mouse0.83548216
71P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83503498
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80594199
73ZNF274_21170338_ChIP-Seq_K562_Hela0.79926430
74HOXB7_26014856_ChIP-Seq_BT474_Human0.79538513
75SA1_27219007_Chip-Seq_Bcells_Human0.78811615
76SOX2_21211035_ChIP-Seq_LN229_Human0.78506998
77SMAD1_18555785_Chip-Seq_ESCs_Mouse0.78009864
78* GATA6_21074721_ChIP-Seq_CACO-2_Human0.77827070
79KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77482824
80SPI1_20517297_ChIP-Seq_HL60_Human0.77342821
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.76768397
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.76741257
83SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.76074360
84OCT4_18555785_Chip-Seq_ESCs_Mouse0.75406771
85CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75355754
86FOXH1_21741376_ChIP-Seq_ESCs_Human0.75315140
87KDM2B_26808549_Chip-Seq_REH_Human0.74608247
88CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73424339
89SUZ12_27294783_Chip-Seq_ESCs_Mouse0.73316268
90SRY_22984422_ChIP-ChIP_TESTIS_Rat0.73093757
91* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.73068991
92NMYC_18555785_Chip-Seq_ESCs_Mouse0.71762308
93CTCF_18555785_Chip-Seq_ESCs_Mouse0.71342702
94ERG_20517297_ChIP-Seq_VCAP_Human0.71258630
95* RBPJ_21746931_ChIP-Seq_IB4_Human0.70882342
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.70712122
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70700006
98E2F1_20622854_ChIP-Seq_HELA_Human0.69991151
99VDR_22108803_ChIP-Seq_LS180_Human0.69615463
100SOX2_18555785_Chip-Seq_ESCs_Mouse0.69493218

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002234_abnormal_pharynx_morphology8.38167457
2MP0001873_stomach_inflammation7.57969305
3MP0006082_CNS_inflammation5.31383790
4MP0000465_gastrointestinal_hemorrhage3.91558229
5MP0004510_myositis3.50802907
6MP0005671_abnormal_response_to3.48884390
7MP0004130_abnormal_muscle_cell2.84270632
8MP0001835_abnormal_antigen_presentation2.76184122
9MP0001851_eye_inflammation2.53134621
10MP0002933_joint_inflammation2.52102247
11MP0001800_abnormal_humoral_immune2.31663087
12MP0005360_urolithiasis2.27402867
13MP0003763_abnormal_thymus_physiology2.26304897
14MP0003436_decreased_susceptibility_to2.21177277
15MP0005025_abnormal_response_to2.19347898
16MP0005000_abnormal_immune_tolerance2.09462294
17MP0002148_abnormal_hypersensitivity_rea1.92658158
18MP0008875_abnormal_xenobiotic_pharmacok1.91755947
19MP0004782_abnormal_surfactant_physiolog1.83158569
20MP0009785_altered_susceptibility_to1.81550726
21MP0002419_abnormal_innate_immunity1.78754073
22MP0002723_abnormal_immune_serum1.77048531
23MP0002452_abnormal_antigen_presenting1.73027903
24MP0001663_abnormal_digestive_system1.69405227
25MP0001790_abnormal_immune_system1.65957068
26MP0005387_immune_system_phenotype1.65957068
27MP0002420_abnormal_adaptive_immunity1.65712771
28MP0009333_abnormal_splenocyte_physiolog1.65037385
29MP0003646_muscle_fatigue1.59993493
30MP0001819_abnormal_immune_cell1.59541245
31MP0005666_abnormal_adipose_tissue1.58765385
32MP0008872_abnormal_physiological_respon1.50352462
33MP0005166_decreased_susceptibility_to1.50325092
34MP0003724_increased_susceptibility_to1.42648047
35MP0001845_abnormal_inflammatory_respons1.41775626
36MP0002405_respiratory_system_inflammati1.39387708
37MP0003075_altered_response_to1.33012402
38MP0008469_abnormal_protein_level1.27204398
39MP0004947_skin_inflammation1.26871823
40MP0000716_abnormal_immune_system1.26247681
41MP0000703_abnormal_thymus_morphology1.25783077
42MP0005381_digestive/alimentary_phenotyp1.25674800
43MP0010155_abnormal_intestine_physiology1.23056049
44MP0000685_abnormal_immune_system1.19830444
45MP0002398_abnormal_bone_marrow1.16961187
46MP0001533_abnormal_skeleton_physiology1.11125974
47MP0002722_abnormal_immune_system1.10643263
48MP0003300_gastrointestinal_ulcer1.10034842
49MP0002177_abnormal_outer_ear1.05181874
50MP0005334_abnormal_fat_pad0.99927602
51MP0003866_abnormal_defecation0.99887958
52MP0002693_abnormal_pancreas_physiology0.98268848
53MP0008873_increased_physiological_sensi0.97946515
54MP0000569_abnormal_digit_pigmentation0.95552987
55MP0000689_abnormal_spleen_morphology0.94538242
56MP0003011_delayed_dark_adaptation0.92662583
57MP0002429_abnormal_blood_cell0.89186632
58MP0001664_abnormal_digestion0.87794357
59MP0002277_abnormal_respiratory_mucosa0.87402462
60MP0004381_abnormal_hair_follicle0.86858628
61MP0000343_altered_response_to0.82607875
62MP0001529_abnormal_vocalization0.78631618
63MP0005310_abnormal_salivary_gland0.78510896
64MP0009764_decreased_sensitivity_to0.76211412
65MP0002932_abnormal_joint_morphology0.72431383
66MP0004264_abnormal_extraembryonic_tissu0.70199005
67MP0001905_abnormal_dopamine_level0.68331683
68MP0004142_abnormal_muscle_tone0.67920485
69MP0005375_adipose_tissue_phenotype0.67137095
70MP0009384_cardiac_valve_regurgitation0.66629133
71MP0001348_abnormal_lacrimal_gland0.65560908
72MP0009115_abnormal_fat_cell0.65327340
73MP0003638_abnormal_response/metabolism_0.64918618
74MP0005448_abnormal_energy_balance0.63594953
75MP0001853_heart_inflammation0.59461717
76MP0002089_abnormal_postnatal_growth/wei0.58275905
77MP0008569_lethality_at_weaning0.57963747
78MP0000627_abnormal_mammary_gland0.57357226
79MP0005464_abnormal_platelet_physiology0.56724307
80MP0005253_abnormal_eye_physiology0.56419459
81MP0003448_altered_tumor_morphology0.56215932
82MP0009763_increased_sensitivity_to0.56213976
83MP0002163_abnormal_gland_morphology0.54418549
84MP0000372_irregular_coat_pigmentation0.53206652
85MP0008932_abnormal_embryonic_tissue0.52897167
86MP0002132_abnormal_respiratory_system0.52542498
87MP0003195_calcinosis0.52335356
88MP0003950_abnormal_plasma_membrane0.52292891
89MP0001727_abnormal_embryo_implantation0.52167127
90MP0000230_abnormal_systemic_arterial0.51174850
91MP0002998_abnormal_bone_remodeling0.50019577
92MP0003936_abnormal_reproductive_system0.49112820
93MP0002166_altered_tumor_susceptibility0.48682485
94MP0003567_abnormal_fetal_cardiomyocyte0.48012355
95MP0003045_fibrosis0.47948836
96MP0005386_behavior/neurological_phenoty0.47516633
97MP0004924_abnormal_behavior0.47516633
98MP0001765_abnormal_ion_homeostasis0.46122999
99MP0010307_abnormal_tumor_latency0.43836000
100MP0008877_abnormal_DNA_methylation0.42535516

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)8.66573452
2Neonatal hypoglycemia (HP:0001998)8.31455237
3Lip pit (HP:0100267)7.62821002
4Decreased activity of mitochondrial respiratory chain (HP:0008972)6.97684188
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)6.97684188
6Chin dimple (HP:0010751)6.91812822
7Enlarged epiphyses (HP:0010580)6.89134291
8Anterior segment dysgenesis (HP:0007700)6.35503406
9Sparse lateral eyebrow (HP:0005338)6.34062717
10Depressed nasal tip (HP:0000437)6.28568877
11Glucose intolerance (HP:0000833)6.21836368
12Abnormality of the fingertips (HP:0001211)5.48195074
13Myotonia (HP:0002486)5.41555267
14Premature skin wrinkling (HP:0100678)5.34655343
15Agammaglobulinemia (HP:0004432)5.23490625
16Insulin-resistant diabetes mellitus (HP:0000831)4.86325841
17Hypoplasia of the iris (HP:0007676)4.75628330
18Abnormality of the columella (HP:0009929)4.73095136
19Abnormal glucose tolerance (HP:0001952)4.25675474
20Stomatitis (HP:0010280)4.12960702
21Epileptic encephalopathy (HP:0200134)4.12757434
22Recurrent gram-negative bacterial infections (HP:0005420)4.01573959
23Fatigable weakness (HP:0003473)3.77430424
24Abnormality of the neuromuscular junction (HP:0003398)3.77430424
25Hyperglycemia (HP:0003074)3.70337179
26Ectropion (HP:0000656)3.64031612
27Meningitis (HP:0001287)3.31086717
28Cellulitis (HP:0100658)3.16907326
29T lymphocytopenia (HP:0005403)3.12203960
30Easy fatigability (HP:0003388)3.09951842
31* Abnormality of T cell number (HP:0011839)2.93479180
32Recurrent abscess formation (HP:0002722)2.79269988
33Mask-like facies (HP:0000298)2.78118666
34Long palpebral fissure (HP:0000637)2.76384490
35Hypoproteinemia (HP:0003075)2.71932641
36Prominent supraorbital ridges (HP:0000336)2.60030684
37Alveolar cell carcinoma (HP:0006519)2.56699426
38Periodontitis (HP:0000704)2.54737019
39Type 2 muscle fiber atrophy (HP:0003554)2.49410579
40Verrucae (HP:0200043)2.44711672
41Papilloma (HP:0012740)2.44711672
42Hemiplegia (HP:0002301)2.41474141
43Abnormality of the anterior chamber (HP:0000593)2.39975162
44Cerebellar dysplasia (HP:0007033)2.34901445
45Abnormality of the pupil (HP:0000615)2.32324486
46Muscle fiber atrophy (HP:0100295)2.31650353
47Megalocornea (HP:0000485)2.31579237
48Abnormality of binocular vision (HP:0011514)2.29915682
49Diplopia (HP:0000651)2.29915682
50Gingivitis (HP:0000230)2.27976337
51Cupped ear (HP:0000378)2.27421526
52Neoplasm of the tracheobronchial system (HP:0100552)2.24450060
53Encephalitis (HP:0002383)2.18205223
54Optic neuritis (HP:0100653)2.16180220
55Retrobulbar optic neuritis (HP:0100654)2.16180220
56Chronic diarrhea (HP:0002028)2.15484227
57* Abnormality of T cells (HP:0002843)2.13009007
58Skin pits (HP:0100276)2.12909385
59Myositis (HP:0100614)2.11937418
60Insulin resistance (HP:0000855)2.11530344
61IgG deficiency (HP:0004315)2.05656562
62Osteomyelitis (HP:0002754)2.02131734
63* Leukocytosis (HP:0001974)2.01745278
64Hypodontia (HP:0000668)1.99619097
65Elevated erythrocyte sedimentation rate (HP:0003565)1.96736628
66Coarctation of aorta (HP:0001680)1.96716611
67Sepsis (HP:0100806)1.95947679
68Abnormality of macrophages (HP:0004311)1.93666426
69Adactyly (HP:0009776)1.87959156
70Nonprogressive disorder (HP:0003680)1.85089353
71Eczematoid dermatitis (HP:0000976)1.84716571
72Orchitis (HP:0100796)1.84077272
73Abnormality of the renal collecting system (HP:0004742)1.83341898
74Skin rash (HP:0000988)1.82671546
75Duplicated collecting system (HP:0000081)1.82108292
76Ureteral stenosis (HP:0000071)1.81235991
77Constricted visual fields (HP:0001133)1.75114916
78Reduced subcutaneous adipose tissue (HP:0003758)1.73896683
79Pulmonary infiltrates (HP:0002113)1.72783499
80Non-midline cleft lip (HP:0100335)1.72725130
81Death in infancy (HP:0001522)1.69409689
82Broad nasal tip (HP:0000455)1.68488695
83Mediastinal lymphadenopathy (HP:0100721)1.68246193
84Dental malocclusion (HP:0000689)1.67356907
85Microdontia (HP:0000691)1.67153477
86Preauricular skin tag (HP:0000384)1.66353392
87Severe combined immunodeficiency (HP:0004430)1.66175797
88Long eyelashes (HP:0000527)1.65685341
89Ureteral obstruction (HP:0006000)1.64279334
90* Neutropenia (HP:0001875)1.63259026
91Hypoalbuminemia (HP:0003073)1.62642881
92Abnormal albumin level (HP:0012116)1.62642881
93Pulmonary embolism (HP:0002204)1.61775746
94Posterior embryotoxon (HP:0000627)1.60951878
95Abnormality of the line of Schwalbe (HP:0008048)1.58261289
96Neck muscle weakness (HP:0000467)1.57050900
97Oligodontia (HP:0000677)1.54024289
98Striae distensae (HP:0001065)1.52958654
99Chronic obstructive pulmonary disease (HP:0006510)1.51867394
100Obstructive lung disease (HP:0006536)1.51867394

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CA7.71766576
2CDK193.73035847
3MAP3K62.59457430
4CAMK1D2.40795158
5RET2.38187003
6BMPR22.35267803
7CAMKK22.23833035
8TXK2.23538048
9OXSR12.20861376
10KIT2.20373769
11TLK110.4476149
12GRK71.95526036
13MAP2K31.94587232
14MAP2K61.79744901
15MAPK121.62581750
16TGFBR21.61324658
17PDGFRB1.48996322
18CAMK1G1.48718861
19MOS1.43254022
20STK101.39773575
21PTK21.25420216
22ZAP701.23852048
23LCK1.16713055
24GRK61.14459369
25MAP4K11.12091457
26PRKCG1.03484607
27GRK50.90524716
28CSK0.89234609
29PRKCH0.88943533
30MAP2K40.88415807
31FES0.85205462
32JAK30.84599314
33ITK0.84536155
34KDR0.83083705
35ADRBK20.80139569
36MAP3K110.79958693
37MARK30.74382728
38TAOK30.72613336
39SYK0.71530574
40CAMKK10.70698850
41ADRBK10.70106396
42IKBKB0.61630714
43JAK20.61320213
44MUSK0.57991700
45BTK0.57240024
46TESK10.56411696
47INSR0.53227883
48MAP3K50.50192091
49STK110.49625284
50PRKCQ0.46512903
51TNK20.45935648
52IGF1R0.45427425
53MINK10.43611589
54PRKD10.40053221
55FYN0.39412604
56PBK0.39058299
57PDK10.37600067
58MST40.31593738
59CAMK10.30681235
60PAK10.30508756
61PRKG10.29326633
62MATK0.28673535
63LYN0.26491347
64HCK0.25294037
65TESK20.22327172
66MAP4K20.22071425
67TEC0.21933683
68TYK20.21504881
69CAMK2A0.20750950
70IKBKE0.19511644
71CAMK40.19193024
72EPHA30.18888613
73EIF2AK20.17737136
74CSNK1D0.17724837
75INSRR0.16144843
76TYRO30.15591016
77RIPK40.12786181
78PRKACA0.12761437
79PRKCA0.11367941
80LIMK10.10744283
81JAK10.10652971
82GRK10.09501683
83PRKCD0.09301379
84FRK0.08898975
85FGR0.08555846
86BLK0.07435353
87OBSCN0.05896181
88EGFR0.05538513
89SGK30.04995645
90WNK40.04917864
91ERBB20.04876000
92FGFR10.04793758
93PIM10.04617810
94PRKCB0.03813304
95MAPKAPK20.03409143
96SRC0.02934845
97CSNK2A20.01741730
98WNK30.01377902
99ABL10.01158121
100DAPK10.00257814

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002326.00055198
2Vitamin B6 metabolism_Homo sapiens_hsa007504.38458019
3* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.06353095
4* Graft-versus-host disease_Homo sapiens_hsa053322.69051010
5Primary immunodeficiency_Homo sapiens_hsa053402.64310542
6Malaria_Homo sapiens_hsa051442.61338515
7Pentose phosphate pathway_Homo sapiens_hsa000302.31339814
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.30947997
9Linoleic acid metabolism_Homo sapiens_hsa005912.29362700
10* Autoimmune thyroid disease_Homo sapiens_hsa053202.28729203
11* Allograft rejection_Homo sapiens_hsa053302.23496939
12T cell receptor signaling pathway_Homo sapiens_hsa046602.17553475
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.12345811
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.04682451
15* Measles_Homo sapiens_hsa051621.88087488
16Rheumatoid arthritis_Homo sapiens_hsa053231.76198874
17* African trypanosomiasis_Homo sapiens_hsa051431.72516465
18Legionellosis_Homo sapiens_hsa051341.66781368
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.65402639
20* Type I diabetes mellitus_Homo sapiens_hsa049401.60478501
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.59043065
22Viral myocarditis_Homo sapiens_hsa054161.51840118
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42103096
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40897934
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39526048
26* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29054407
27RNA polymerase_Homo sapiens_hsa030201.28118049
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27162789
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.25951309
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25682845
31Leishmaniasis_Homo sapiens_hsa051401.24135297
32Staphylococcus aureus infection_Homo sapiens_hsa051501.15705809
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.15589665
34Antigen processing and presentation_Homo sapiens_hsa046121.13624806
35Prolactin signaling pathway_Homo sapiens_hsa049171.09959659
36Osteoclast differentiation_Homo sapiens_hsa043801.09752479
37Type II diabetes mellitus_Homo sapiens_hsa049301.09033476
38Hematopoietic cell lineage_Homo sapiens_hsa046401.07302292
39TNF signaling pathway_Homo sapiens_hsa046681.04535536
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98168657
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95842165
42B cell receptor signaling pathway_Homo sapiens_hsa046620.94782909
43* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94467693
44VEGF signaling pathway_Homo sapiens_hsa043700.94248499
45Intestinal immune network for IgA production_Homo sapiens_hsa046720.90632113
46* Influenza A_Homo sapiens_hsa051640.90206482
47Pertussis_Homo sapiens_hsa051330.88435192
48Fat digestion and absorption_Homo sapiens_hsa049750.84357574
49Chemokine signaling pathway_Homo sapiens_hsa040620.82562576
50Amoebiasis_Homo sapiens_hsa051460.81468256
51Acute myeloid leukemia_Homo sapiens_hsa052210.80714775
52Renal cell carcinoma_Homo sapiens_hsa052110.80648574
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.80596018
54Asthma_Homo sapiens_hsa053100.80247326
55Non-small cell lung cancer_Homo sapiens_hsa052230.79948535
56Salmonella infection_Homo sapiens_hsa051320.78434447
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77894961
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76398665
59Toxoplasmosis_Homo sapiens_hsa051450.72781820
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70318824
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.69966294
62Platelet activation_Homo sapiens_hsa046110.68772379
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66934391
64Insulin resistance_Homo sapiens_hsa049310.63728937
65Tuberculosis_Homo sapiens_hsa051520.61283240
66* Apoptosis_Homo sapiens_hsa042100.59364944
67Complement and coagulation cascades_Homo sapiens_hsa046100.51748941
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48296885
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.44266696
70Colorectal cancer_Homo sapiens_hsa052100.44158167
71Hepatitis C_Homo sapiens_hsa051600.43782699
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42931121
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42886643
74Pancreatic cancer_Homo sapiens_hsa052120.42572048
75mTOR signaling pathway_Homo sapiens_hsa041500.40799621
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39677716
77Arachidonic acid metabolism_Homo sapiens_hsa005900.39351274
78ErbB signaling pathway_Homo sapiens_hsa040120.38911783
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.38471158
80Retinol metabolism_Homo sapiens_hsa008300.37248751
81cAMP signaling pathway_Homo sapiens_hsa040240.37143315
82Chronic myeloid leukemia_Homo sapiens_hsa052200.36562190
83Small cell lung cancer_Homo sapiens_hsa052220.36021423
84Choline metabolism in cancer_Homo sapiens_hsa052310.34757270
85Ether lipid metabolism_Homo sapiens_hsa005650.31023819
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29109927
87Melanoma_Homo sapiens_hsa052180.28481073
88Endometrial cancer_Homo sapiens_hsa052130.28362687
89Glioma_Homo sapiens_hsa052140.26394665
90Chemical carcinogenesis_Homo sapiens_hsa052040.24910344
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24030925
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.23314706
93* FoxO signaling pathway_Homo sapiens_hsa040680.22882122
94HTLV-I infection_Homo sapiens_hsa051660.21287252
95* Hepatitis B_Homo sapiens_hsa051610.21215931
96Dorso-ventral axis formation_Homo sapiens_hsa043200.20603606
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.19626743
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19377847
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18979057
100Cholinergic synapse_Homo sapiens_hsa047250.18898512

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