FASN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)7.42044837
2biotin metabolic process (GO:0006768)6.96198782
3fatty acid transmembrane transport (GO:1902001)6.53936838
4carnitine shuttle (GO:0006853)6.50199744
5triglyceride catabolic process (GO:0019433)6.12283951
6acylglycerol catabolic process (GO:0046464)5.70623200
7neutral lipid catabolic process (GO:0046461)5.70623200
8regulation of sequestering of triglyceride (GO:0010889)5.40974029
9alpha-linolenic acid metabolic process (GO:0036109)5.39640119
10positive regulation of fatty acid beta-oxidation (GO:0032000)5.31569442
11* triglyceride biosynthetic process (GO:0019432)5.29100429
12* fatty-acyl-CoA biosynthetic process (GO:0046949)5.28000080
13white fat cell differentiation (GO:0050872)5.24407049
14coenzyme A biosynthetic process (GO:0015937)5.14695988
15* acyl-CoA biosynthetic process (GO:0071616)5.07674537
16* thioester biosynthetic process (GO:0035384)5.07674537
17* acylglycerol biosynthetic process (GO:0046463)5.07384626
18* neutral lipid biosynthetic process (GO:0046460)5.07384626
19regulation of cholesterol biosynthetic process (GO:0045540)5.06811811
20carnitine transmembrane transport (GO:1902603)4.83600835
21* acetyl-CoA metabolic process (GO:0006084)4.73736156
22* long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.72413307
23valine metabolic process (GO:0006573)4.71142399
24regulation of fatty acid beta-oxidation (GO:0031998)4.60039034
25positive regulation of fatty acid oxidation (GO:0046321)4.59232554
26* fatty-acyl-CoA metabolic process (GO:0035337)4.52033792
27regulation of cholesterol storage (GO:0010885)4.46490244
28amino-acid betaine transport (GO:0015838)4.44385137
29carnitine transport (GO:0015879)4.44385137
30desmosome organization (GO:0002934)4.43123248
31fatty acid homeostasis (GO:0055089)4.31973039
32* long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.27317073
33brown fat cell differentiation (GO:0050873)4.26927679
34coenzyme A metabolic process (GO:0015936)4.22716054
35sulfur amino acid catabolic process (GO:0000098)4.22023066
36* triglyceride metabolic process (GO:0006641)4.15412726
37fatty acid beta-oxidation (GO:0006635)4.11982663
38glycerolipid catabolic process (GO:0046503)4.07663256
39plasma lipoprotein particle clearance (GO:0034381)4.00991275
40cytoskeletal anchoring at plasma membrane (GO:0007016)4.00342596
41* acylglycerol metabolic process (GO:0006639)3.95694671
42COPI coating of Golgi vesicle (GO:0048205)3.95107403
43Golgi transport vesicle coating (GO:0048200)3.95107403
44regulation of triglyceride biosynthetic process (GO:0010866)3.91479855
45activation of Rac GTPase activity (GO:0032863)3.91037229
46* neutral lipid metabolic process (GO:0006638)3.88889064
47semaphorin-plexin signaling pathway (GO:0071526)3.88621546
48positive regulation of lipid catabolic process (GO:0050996)3.85311712
49regulation of fatty acid oxidation (GO:0046320)3.84968265
50intracellular lipid transport (GO:0032365)3.83951358
51negative regulation of cell size (GO:0045792)3.83029744
52peptidyl-tyrosine autophosphorylation (GO:0038083)3.69193407
53pentose-phosphate shunt (GO:0006098)3.68711453
54negative regulation of fatty acid biosynthetic process (GO:0045717)3.67250702
55fatty acid oxidation (GO:0019395)3.63101546
56regulation of glucose import in response to insulin stimulus (GO:2001273)3.61033713
57epithelial cell-cell adhesion (GO:0090136)3.58928595
58adherens junction assembly (GO:0034333)3.56872398
59tricarboxylic acid metabolic process (GO:0072350)3.56624668
60triglyceride homeostasis (GO:0070328)3.56035648
61acylglycerol homeostasis (GO:0055090)3.56035648
62NADPH regeneration (GO:0006740)3.55463434
63fatty acid catabolic process (GO:0009062)3.55362992
64regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.55172651
65regulation of triglyceride metabolic process (GO:0090207)3.54659245
66lipid oxidation (GO:0034440)3.54535796
67lipid particle organization (GO:0034389)3.51845575
68positive regulation of triglyceride metabolic process (GO:0090208)3.51470161
69protein heterotrimerization (GO:0070208)3.50376918
70regulation of cholesterol homeostasis (GO:2000188)3.49966244
71regulation of triglyceride catabolic process (GO:0010896)3.47740156
72planar cell polarity pathway involved in neural tube closure (GO:0090179)3.47696666
73positive regulation of histone deacetylation (GO:0031065)3.46411630
74basement membrane organization (GO:0071711)3.44865236
75regulation of translational fidelity (GO:0006450)3.43283320
76positive regulation of fatty acid metabolic process (GO:0045923)3.37794320
77epithelial cell differentiation involved in prostate gland development (GO:0060742)3.36423578
78apoptotic process involved in morphogenesis (GO:0060561)3.33723765
79focal adhesion assembly (GO:0048041)3.33067944
80cell-substrate adherens junction assembly (GO:0007045)3.33067944
81proline metabolic process (GO:0006560)3.32716099
82negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.32230517
83cell-cell junction maintenance (GO:0045217)3.27060694
84retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.26716360
85quaternary ammonium group transport (GO:0015697)3.26110683
86complement activation, alternative pathway (GO:0006957)3.25488053
87positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.24847525
88CDP-diacylglycerol biosynthetic process (GO:0016024)3.24286850
89regulation of mammary gland epithelial cell proliferation (GO:0033599)3.23266518
90ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.22548713
91nucleoside bisphosphate biosynthetic process (GO:0033866)3.22548713
92purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.22548713
93regulation of cholesterol metabolic process (GO:0090181)3.20268104
94protein retention in ER lumen (GO:0006621)3.19680804
95branched-chain amino acid metabolic process (GO:0009081)3.19170705
96regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.18980677
97glucose catabolic process (GO:0006007)3.17691451
98* acyl-CoA metabolic process (GO:0006637)3.15776512
99* thioester metabolic process (GO:0035383)3.15776512
100regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.13431682
101lipid storage (GO:0019915)3.13340987
102maternal placenta development (GO:0001893)3.13088287
103regulation of cAMP-dependent protein kinase activity (GO:2000479)3.12325772
104positive regulation of glucose import (GO:0046326)3.12287342
105establishment of apical/basal cell polarity (GO:0035089)3.11856764
106proline biosynthetic process (GO:0006561)3.11578454
107embryonic retina morphogenesis in camera-type eye (GO:0060059)3.11183562
108ethanol oxidation (GO:0006069)3.10446527
109maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.09239079
110NADP metabolic process (GO:0006739)3.08444301
111diacylglycerol metabolic process (GO:0046339)3.06683247
112cellular response to lithium ion (GO:0071285)3.06363916
113negative regulation of fatty acid transport (GO:2000192)3.05277541
114positive regulation of triglyceride biosynthetic process (GO:0010867)3.03680868
1152-oxoglutarate metabolic process (GO:0006103)3.02571193
116convergent extension (GO:0060026)3.00285106
117heterochromatin organization (GO:0070828)3.00140134
118positive regulation of lipid storage (GO:0010884)2.98634007
119regulation of NFAT protein import into nucleus (GO:0051532)2.98402185
120insulin-like growth factor receptor signaling pathway (GO:0048009)2.98087984
121monocarboxylic acid catabolic process (GO:0072329)2.96781027
122endothelial cell chemotaxis (GO:0035767)2.95345043
123branched-chain amino acid catabolic process (GO:0009083)2.95158758
124DNA unwinding involved in DNA replication (GO:0006268)2.94973130
125growth hormone receptor signaling pathway (GO:0060396)2.94862145
126triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.94704420
127cell-substrate junction assembly (GO:0007044)2.94212897
128alanine transport (GO:0032328)2.93694027
129fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.93420072
130positive regulation of cellular response to insulin stimulus (GO:1900078)2.92188541
131regulation of lipid catabolic process (GO:0050994)2.91001029
132long-chain fatty acid transport (GO:0015909)2.90084050
133CDP-diacylglycerol metabolic process (GO:0046341)2.89774038
134hemidesmosome assembly (GO:0031581)2.89125963
135short-chain fatty acid metabolic process (GO:0046459)2.87894688
136linoleic acid metabolic process (GO:0043651)2.86616619
137glucose 6-phosphate metabolic process (GO:0051156)2.84210633
138L-serine transport (GO:0015825)2.82846388
139response to dietary excess (GO:0002021)2.81797099
140positive regulation of glycogen biosynthetic process (GO:0045725)2.81672898
141erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.78320351
142L-phenylalanine metabolic process (GO:0006558)2.78320351
143response to food (GO:0032094)2.78199979
144regulation of fatty acid metabolic process (GO:0019217)2.76070514
145glucocorticoid receptor signaling pathway (GO:0042921)2.74959502
146regulation of receptor binding (GO:1900120)2.73211873
147NADH metabolic process (GO:0006734)2.71649177
148branching involved in mammary gland duct morphogenesis (GO:0060444)2.70814079
149mitotic chromosome condensation (GO:0007076)2.66291791
150branching involved in salivary gland morphogenesis (GO:0060445)2.64748808
151atrioventricular valve morphogenesis (GO:0003181)2.63636658
152regulation of chromatin binding (GO:0035561)2.62930857
153spliceosomal tri-snRNP complex assembly (GO:0000244)2.62439848
154negative regulation of cell fate specification (GO:0009996)2.58268751
155regulation of early endosome to late endosome transport (GO:2000641)2.56962192
156embryonic eye morphogenesis (GO:0048048)2.55539878
157positive regulation of steroid biosynthetic process (GO:0010893)2.54039317
158regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.53614320
159gap junction assembly (GO:0016264)2.49466995
160establishment of monopolar cell polarity (GO:0061162)2.47144951
161establishment or maintenance of monopolar cell polarity (GO:0061339)2.47144951
162protein-DNA complex disassembly (GO:0032986)2.47016398
163nucleosome disassembly (GO:0006337)2.47016398
164regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.45656912
165negative regulation of cell fate commitment (GO:0010454)2.45110351
166regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.44643241

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse9.29979323
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.43402068
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.18206593
4* RXR_22158963_ChIP-Seq_LIVER_Mouse3.90912212
5CLOCK_20551151_ChIP-Seq_293T_Human3.75348681
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.39928648
7* LXR_22158963_ChIP-Seq_LIVER_Mouse3.25166451
8ZNF263_19887448_ChIP-Seq_K562_Human3.09237361
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.96692051
10E2F7_22180533_ChIP-Seq_HELA_Human2.92239784
11* TP63_17297297_ChIP-ChIP_HaCaT_Human2.77989493
12* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.64398353
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.63131889
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.59470610
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.58586199
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.92264564
17* LXR_22292898_ChIP-Seq_THP-1_Human1.75931877
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71996998
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71271904
20P300_27058665_Chip-Seq_ZR-75-30cells_Human1.69022467
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.68764286
22* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66404042
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65545106
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64175347
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.64035391
26AR_21909140_ChIP-Seq_LNCAP_Human1.61952284
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.61816955
28* KDM2B_26808549_Chip-Seq_DND41_Human1.58831245
29FOXM1_23109430_ChIP-Seq_U2OS_Human1.58292329
30* RACK7_27058665_Chip-Seq_MCF-7_Human1.57012519
31* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55956523
32* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55887800
33* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51589575
34KDM2B_26808549_Chip-Seq_K562_Human1.50534858
35* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48550539
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.48433928
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48215065
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45043140
39* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44353129
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43670836
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42827082
42* TET1_21451524_ChIP-Seq_MESCs_Mouse1.42764417
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41647882
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.40922351
45* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40890015
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.40388714
47SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.40210189
48TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.36593148
49CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35733699
50* VDR_21846776_ChIP-Seq_THP-1_Human1.33955961
51CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.33551272
52PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.33107504
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32955452
54* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32745512
55* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31759631
56* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31309311
57NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31038429
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.29920330
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29416587
60PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28627178
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28551806
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26667247
63* MYC_22102868_ChIP-Seq_BL_Human1.25458956
64* MYC_18555785_ChIP-Seq_MESCs_Mouse1.23988995
65CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23420432
66CREB1_26743006_Chip-Seq_LNCaP_Human1.22976518
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21850903
68* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21826754
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.21169083
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20154758
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20152942
72* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20086859
73* SA1_27219007_Chip-Seq_ERYTHROID_Human1.18917660
74ESR1_21235772_ChIP-Seq_MCF-7_Human1.18582996
75DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16877299
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16837480
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16716289
78* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.15505052
79MYC_19079543_ChIP-ChIP_MESCs_Mouse1.14358733
80* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14182442
81* XRN2_22483619_ChIP-Seq_HELA_Human1.14009020
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10376841
83DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09633820
84NCOR1_26117541_ChIP-Seq_K562_Human1.09487067
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09068601
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09020986
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08373098
88* FOXA2_19822575_ChIP-Seq_HepG2_Human1.08341520
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07402871
90* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.07316421
91* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07312718
92* ATF3_27146783_Chip-Seq_COLON_Human1.06907735
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06844855
94* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06674604
95FOXO3_23340844_ChIP-Seq_DLD1_Human1.06379528
96CTCF_27219007_Chip-Seq_Bcells_Human1.06319439
97* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06236691
98FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05786472
99TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05685994
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05033846
101* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04003543
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03664874
103TCF7_22412390_ChIP-Seq_EML_Mouse1.02956956
104* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02571155
105EGR1_19374776_ChIP-ChIP_THP-1_Human1.02211129
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01840725
107* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01560214
108* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01553606
109* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00355211
110SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00223667
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00186607
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00052168
113TBX20_22080862_ChIP-Seq_HEART_Mouse0.99460773
114TBX20_22328084_ChIP-Seq_HEART_Mouse0.99460773
115ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99244451
116* RUNX1_27514584_Chip-Seq_MCF-7_Human0.98796940
117ESR1_20079471_ChIP-ChIP_T-47D_Human0.98778814
118PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.96041963
119SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91940182
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91386025
121TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91028455
122EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88377298
123P68_20966046_ChIP-Seq_HELA_Human0.87996884
124NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87303779
125* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86830531
126* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86313603
127PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85428472
128KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85027103
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84078420
130NANOG_21062744_ChIP-ChIP_HESCs_Human0.84022270
131GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83898466
132TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80859134
133SMC4_20622854_ChIP-Seq_HELA_Human0.80572823
134FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.80090161
135* TP53_22127205_ChIP-Seq_IMR90_Human0.80053668
136CHD1_26751641_Chip-Seq_LNCaP_Human0.79586150
137GATA1_19941826_ChIP-Seq_K562_Human0.79350035
138GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78756955

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose6.55179913
2MP0005666_abnormal_adipose_tissue4.73265242
3MP0004130_abnormal_muscle_cell4.18042039
4MP0004185_abnormal_adipocyte_glucose4.17852135
5MP0008438_abnormal_cutaneous_collagen3.85171273
6MP0003705_abnormal_hypodermis_morpholog3.59001765
7MP0000566_synostosis3.45128691
8MP0005375_adipose_tissue_phenotype3.43097046
9MP0002139_abnormal_hepatobiliary_system3.34495330
10MP0010329_abnormal_lipoprotein_level3.18856814
11MP0005365_abnormal_bile_salt3.07195565
12MP0002971_abnormal_brown_adipose2.92103765
13MP0005275_abnormal_skin_tensile2.51653865
14MP0005360_urolithiasis2.45979107
15MP0009115_abnormal_fat_cell2.43252933
16MP0000003_abnormal_adipose_tissue2.30662977
17* MP0002118_abnormal_lipid_homeostasis2.29256015
18MP0002970_abnormal_white_adipose2.21479129
19MP0005451_abnormal_body_composition2.08265048
20MP0003191_abnormal_cellular_cholesterol2.06377764
21* MP0005334_abnormal_fat_pad2.04122249
22MP0000013_abnormal_adipose_tissue2.01989488
23MP0005085_abnormal_gallbladder_physiolo2.01245009
24MP0003123_paternal_imprinting1.88766466
25MP0005076_abnormal_cell_differentiation1.85357009
26MP0004264_abnormal_extraembryonic_tissu1.84573125
27* MP0000609_abnormal_liver_physiology1.77476316
28MP0002837_dystrophic_cardiac_calcinosis1.67391777
29MP0001661_extended_life_span1.61060261
30MP0001881_abnormal_mammary_gland1.58099644
31MP0002796_impaired_skin_barrier1.57729525
32MP0005409_darkened_coat_color1.57713843
33MP0002089_abnormal_postnatal_growth/wei1.56648327
34MP0000678_abnormal_parathyroid_gland1.56300810
35MP0003942_abnormal_urinary_system1.54746362
36MP0003959_abnormal_lean_body1.48162947
37MP0004272_abnormal_basement_membrane1.46670564
38MP0010352_gastrointestinal_tract_polyps1.45902072
39MP0001730_embryonic_growth_arrest1.45679551
40MP0005448_abnormal_energy_balance1.41720038
41MP0004233_abnormal_muscle_weight1.39214018
42MP0002009_preneoplasia1.37054813
43MP0002098_abnormal_vibrissa_morphology1.36883137
44MP0000534_abnormal_ureter_morphology1.35072410
45MP0005257_abnormal_intraocular_pressure1.34646925
46MP0003045_fibrosis1.33147415
47MP0003315_abnormal_perineum_morphology1.32680531
48MP0005535_abnormal_body_temperature1.32240113
49MP0010234_abnormal_vibrissa_follicle1.30144957
50MP0000579_abnormal_nail_morphology1.29145669
51MP0003566_abnormal_cell_adhesion1.27608334
52MP0004782_abnormal_surfactant_physiolog1.26253600
53MP0001348_abnormal_lacrimal_gland1.25663140
54MP0002060_abnormal_skin_morphology1.22576360
55MP0002877_abnormal_melanocyte_morpholog1.21298304
56MP0009780_abnormal_chondrocyte_physiolo1.20667173
57MP0000467_abnormal_esophagus_morphology1.17363426
58MP0003283_abnormal_digestive_organ1.13256901
59* MP0005452_abnormal_adipose_tissue1.11890493
60MP0003984_embryonic_growth_retardation1.11424479
61MP0003252_abnormal_bile_duct1.11169263
62MP0000627_abnormal_mammary_gland1.09694469
63* MP0002078_abnormal_glucose_homeostasis1.08654646
64MP0005380_embryogenesis_phenotype1.07606403
65MP0001672_abnormal_embryogenesis/_devel1.07606403
66MP0005332_abnormal_amino_acid1.06388257
67MP0005319_abnormal_enzyme/_coenzyme1.06092726
68MP0003690_abnormal_glial_cell1.04620442
69MP0005584_abnormal_enzyme/coenzyme_acti1.02904317
70MP0009278_abnormal_bone_marrow1.01839298
71MP0008961_abnormal_basal_metabolism1.01455189
72MP0002254_reproductive_system_inflammat0.99660113
73MP0010030_abnormal_orbit_morphology0.99248574
74MP0003111_abnormal_nucleus_morphology0.98456384
75* MP0002080_prenatal_lethality0.98238209
76MP0001216_abnormal_epidermal_layer0.97842826
77MP0008260_abnormal_autophagy0.97698232
78MP0002876_abnormal_thyroid_physiology0.97437790
79MP0004197_abnormal_fetal_growth/weight/0.96570938
80MP0005623_abnormal_meninges_morphology0.95709697
81MP0009840_abnormal_foam_cell0.95276587
82MP0002168_other_aberrant_phenotype0.94073752
83MP0004957_abnormal_blastocyst_morpholog0.93821286
84MP0009672_abnormal_birth_weight0.93743914
85MP0000377_abnormal_hair_follicle0.93390540
86MP0002697_abnormal_eye_size0.93276930
87MP0000462_abnormal_digestive_system0.91985551
88MP0002085_abnormal_embryonic_tissue0.89934863
89MP0001346_abnormal_lacrimal_gland0.89115828
90MP0003693_abnormal_embryo_hatching0.88965507
91MP0000733_abnormal_muscle_development0.87890006
92MP0005083_abnormal_biliary_tract0.86763042
93MP0000762_abnormal_tongue_morphology0.86175376
94MP0005058_abnormal_lysosome_morphology0.84506410
95MP0003385_abnormal_body_wall0.81116014
96MP0009053_abnormal_anal_canal0.80833907
97MP0005647_abnormal_sex_gland0.80726293
98MP0002822_catalepsy0.79984283
99MP0000350_abnormal_cell_proliferation0.78921751
100MP0003806_abnormal_nucleotide_metabolis0.78329607
101MP0008932_abnormal_embryonic_tissue0.77904143
102MP0008875_abnormal_xenobiotic_pharmacok0.77465502
103MP0004087_abnormal_muscle_fiber0.76461730
104MP0005220_abnormal_exocrine_pancreas0.76106396
105MP0001697_abnormal_embryo_size0.75904193
106MP0002084_abnormal_developmental_patter0.75371783
107MP0004381_abnormal_hair_follicle0.74622579
108MP0003890_abnormal_embryonic-extraembry0.74377440
109MP0002909_abnormal_adrenal_gland0.74065754
110MP0003861_abnormal_nervous_system0.73681712
111MP0006138_congestive_heart_failure0.73605303
112MP0000751_myopathy0.72591359
113MP0002269_muscular_atrophy0.72459963
114MP0010771_integument_phenotype0.71243976
115MP0002166_altered_tumor_susceptibility0.71081257
116* MP0000598_abnormal_liver_morphology0.70744252
117MP0009931_abnormal_skin_appearance0.70658008
118MP0003119_abnormal_digestive_system0.70383236
119MP0001177_atelectasis0.68906182
120MP0002006_tumorigenesis0.68777786
121MP0005501_abnormal_skin_physiology0.68252499
122MP0001666_abnormal_nutrient_absorption0.67786043
123MP0003453_abnormal_keratinocyte_physiol0.66771722
124MP0003329_amyloid_beta_deposits0.66141569
125MP0010630_abnormal_cardiac_muscle0.65873757
126MP0002249_abnormal_larynx_morphology0.64596396
127MP0004858_abnormal_nervous_system0.64523955
128* MP0003953_abnormal_hormone_level0.63735846
129* MP0003948_abnormal_gas_homeostasis0.63649193
130MP0002295_abnormal_pulmonary_circulatio0.62259452
131MP0009703_decreased_birth_body0.61662355
132MP0003115_abnormal_respiratory_system0.61615681
133MP0001958_emphysema0.60419249
134MP0002108_abnormal_muscle_morphology0.60180888
135MP0000759_abnormal_skeletal_muscle0.60074440
136MP0001727_abnormal_embryo_implantation0.59524894
137MP0003300_gastrointestinal_ulcer0.59055265
138MP0000639_abnormal_adrenal_gland0.58705107
139MP0005248_abnormal_Harderian_gland0.57911380
140MP0000371_diluted_coat_color0.57720796
141MP0002086_abnormal_extraembryonic_tissu0.57567012
142MP0002111_abnormal_tail_morphology0.57202739
143MP0000537_abnormal_urethra_morphology0.56351809
144MP0005397_hematopoietic_system_phenotyp0.56200409
145MP0001545_abnormal_hematopoietic_system0.56200409
146MP0004019_abnormal_vitamin_homeostasis0.56097252
147MP0008995_early_reproductive_senescence0.55620976
148MP0005023_abnormal_wound_healing0.54412961
149MP0001849_ear_inflammation0.53817695
150MP0000604_amyloidosis0.53373997
151MP0002088_abnormal_embryonic_growth/wei0.52798362

Predicted human phenotypes

RankGene SetZ-score
1Acanthosis nigricans (HP:0000956)4.73194743
2Oligomenorrhea (HP:0000876)4.59900829
3Hyperglycinuria (HP:0003108)4.36627976
4Turricephaly (HP:0000262)4.18386296
5Hypertriglyceridemia (HP:0002155)3.83284954
6Cerebral aneurysm (HP:0004944)3.82624936
7Abnormality of serine family amino acid metabolism (HP:0010894)3.79342761
8Abnormality of glycine metabolism (HP:0010895)3.79342761
9Septate vagina (HP:0001153)3.57835917
10Broad face (HP:0000283)3.41950870
11Epidermoid cyst (HP:0200040)3.39600940
12Complement deficiency (HP:0004431)3.29834174
13Growth hormone excess (HP:0000845)3.22876840
14Xanthomatosis (HP:0000991)3.21011490
15Deep venous thrombosis (HP:0002625)3.06890511
16Myoglobinuria (HP:0002913)3.06458144
17Flat acetabular roof (HP:0003180)3.01267155
18Difficulty running (HP:0009046)3.00781777
19Myocardial infarction (HP:0001658)3.00104067
20Ketosis (HP:0001946)2.98811652
21Hypoalphalipoproteinemia (HP:0003233)2.98406832
22Hyperammonemia (HP:0001987)2.87334481
23Ketoacidosis (HP:0001993)2.85214281
24Long foot (HP:0001833)2.84872640
25Increased connective tissue (HP:0009025)2.84275487
26Advanced eruption of teeth (HP:0006288)2.82299536
27Hyperglycinemia (HP:0002154)2.76791850
28Ulnar bowing (HP:0003031)2.76709737
29Hypoglycemic coma (HP:0001325)2.63505127
30Abnormality of the distal phalanx of the thumb (HP:0009617)2.62937057
31Shallow orbits (HP:0000586)2.60900213
32Ankle contracture (HP:0006466)2.57452041
33Hyperlipoproteinemia (HP:0010980)2.57373312
34Abnormality of the lower motor neuron (HP:0002366)2.55585539
35Obstructive sleep apnea (HP:0002870)2.55464426
36Abnormality of proline metabolism (HP:0010907)2.54020099
37Hydroxyprolinuria (HP:0003080)2.54020099
38Bronchomalacia (HP:0002780)2.54014577
39Insulin resistance (HP:0000855)2.53820130
40Insulin-resistant diabetes mellitus (HP:0000831)2.51317839
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.45434503
42Testicular atrophy (HP:0000029)2.42065376
43Abnormality of complement system (HP:0005339)2.41335987
44Hypolipoproteinemia (HP:0010981)2.40719252
45Achilles tendon contracture (HP:0001771)2.40119018
46Asymmetry of the thorax (HP:0001555)2.39743865
47Abnormality of the distal phalanges of the toes (HP:0010182)2.34644910
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.33983349
49Pseudobulbar signs (HP:0002200)2.32324308
50Long palpebral fissure (HP:0000637)2.32150512
51Hemorrhage of the eye (HP:0011885)2.30666852
52Abnormality of the Achilles tendon (HP:0005109)2.30262901
53Subcapsular cataract (HP:0000523)2.27404872
54Distal lower limb amyotrophy (HP:0008944)2.27177029
55Patellar dislocation (HP:0002999)2.25756060
56Deviation of the thumb (HP:0009603)2.24301495
57Spastic diplegia (HP:0001264)2.24090323
58Abnormality of carpal bone ossification (HP:0006257)2.23764094
59Sparse lateral eyebrow (HP:0005338)2.23632723
60Abnormality of fatty-acid metabolism (HP:0004359)2.22403505
61Macroorchidism (HP:0000053)2.21885432
62Abnormal cartilage morphology (HP:0002763)2.21238941
63Broad metatarsal (HP:0001783)2.20794507
64Abnormality of the phalanges of the hallux (HP:0010057)2.20298219
65Precocious puberty (HP:0000826)2.18582648
66Germ cell neoplasia (HP:0100728)2.18168353
67Stridor (HP:0010307)2.16596921
68Coronal craniosynostosis (HP:0004440)2.16593472
69Disproportionate tall stature (HP:0001519)2.14929936
70Rhabdomyolysis (HP:0003201)2.14518003
71Protrusio acetabuli (HP:0003179)2.14435170
72Increased nuchal translucency (HP:0010880)2.13847195
73Cortical dysplasia (HP:0002539)2.13556668
74Short nail (HP:0001799)2.12907764
75Intrahepatic cholestasis (HP:0001406)2.12393313
76Skin nodule (HP:0200036)2.12068623
77Alopecia of scalp (HP:0002293)2.11747222
78Aplasia involving bones of the extremities (HP:0009825)2.09215787
79Aplasia involving bones of the upper limbs (HP:0009823)2.09215787
80Aplasia of the phalanges of the hand (HP:0009802)2.09215787
81Partial duplication of thumb phalanx (HP:0009944)2.08024477
82Abnormal tarsal ossification (HP:0008369)2.07957659
83Mitral valve prolapse (HP:0001634)2.07851884
84Urethral obstruction (HP:0000796)2.07755665
85Abnormal ossification of hand bones (HP:0005921)2.07648710
86Aneurysm (HP:0002617)2.06939212
87Large hands (HP:0001176)2.05895853
88Increased mean platelet volume (HP:0011877)2.05006672
89Lymphangioma (HP:0100764)2.04913194
90Abnormality of glutamine family amino acid metabolism (HP:0010902)2.04636782
91Dysmetric saccades (HP:0000641)2.04300475
92Enlarged penis (HP:0000040)2.03240835
93Biconcave vertebral bodies (HP:0004586)2.03217631
94Hypercholesterolemia (HP:0003124)2.02263745
95Hypercortisolism (HP:0001578)2.00752018
96Cerebral inclusion bodies (HP:0100314)1.99710208
97Thin bony cortex (HP:0002753)1.98689844
98Insomnia (HP:0100785)1.97558913
99Hand muscle atrophy (HP:0009130)1.97290987
100Proximal placement of thumb (HP:0009623)1.97073054
101Multiple enchondromatosis (HP:0005701)1.94957347
102Back pain (HP:0003418)1.94165678
103Abnormal hemoglobin (HP:0011902)1.93037869
104Easy fatigability (HP:0003388)1.92622191
105Abnormality of the fingertips (HP:0001211)1.91718312
106Hyperthyroidism (HP:0000836)1.90732927
107Hyperacusis (HP:0010780)1.90564121
108Partial duplication of the phalanx of hand (HP:0009999)1.89262244
109Increased variability in muscle fiber diameter (HP:0003557)1.88203703
110Right ventricular cardiomyopathy (HP:0011663)1.86638131
111Bifid scrotum (HP:0000048)1.86556471
112Polycythemia (HP:0001901)1.86312755
113Upper limb amyotrophy (HP:0009129)1.85644994
114Distal upper limb amyotrophy (HP:0007149)1.85644994
115Cervical subluxation (HP:0003308)1.84475890
116Generalized hypotonia (HP:0001290)1.84435727
117Reticulocytosis (HP:0001923)1.84337029
118Hyperpituitarism (HP:0010514)1.84128367
119Lower limb amyotrophy (HP:0007210)1.83909831
120Hypobetalipoproteinemia (HP:0003563)1.83781455
121Truncus arteriosus (HP:0001660)1.83645176
122Insidious onset (HP:0003587)1.83315170
123Termporal pattern (HP:0011008)1.83315170
124Hamartoma of the eye (HP:0010568)1.83196883
125Heterotopia (HP:0002282)1.81976823
126Abnormality of the 4th metacarpal (HP:0010012)1.81271607
127Bone cyst (HP:0012062)1.81228794
128Pili torti (HP:0003777)1.80457206
129Premature skin wrinkling (HP:0100678)1.80024240
130Congenital glaucoma (HP:0001087)1.79135138
131Self-mutilation (HP:0000742)1.78989269
132Bowed forearm bones (HP:0003956)1.78483278
133Bowing of the arm (HP:0006488)1.78483278
134Midface retrusion (HP:0011800)1.76440679
135Annular pancreas (HP:0001734)1.76334021
136Abnormality of the astrocytes (HP:0100707)1.75820490
137Astrocytoma (HP:0009592)1.75820490
138High anterior hairline (HP:0009890)1.73837764
139Rectal prolapse (HP:0002035)1.73716856
140Hypochromic microcytic anemia (HP:0004840)1.73664308
141Arnold-Chiari malformation (HP:0002308)1.73640752
142Hyporeflexia of lower limbs (HP:0002600)1.72927541
143Premature rupture of membranes (HP:0001788)1.72422807
144Renovascular hypertension (HP:0100817)1.72354856
145Bowel incontinence (HP:0002607)1.72298212
146Abnormal foot bone ossification (HP:0010675)1.71931573
147Selective tooth agenesis (HP:0001592)1.70246329
148Axonal loss (HP:0003447)1.69799524
149Hypoparathyroidism (HP:0000829)1.69631923
150Abnormality of monocarboxylic acid metabolism (HP:0010996)1.69081414
151Striae distensae (HP:0001065)1.68279713
152Choanal stenosis (HP:0000452)1.68052236
153Abnormality of glycolysis (HP:0004366)1.68034256
154Neonatal death (HP:0003811)1.66954190
155Anal stenosis (HP:0002025)1.64949257
156Microglossia (HP:0000171)1.64469677
157Abnormal platelet volume (HP:0011876)1.63595564
158Pigmentary retinal degeneration (HP:0001146)1.63231075
159Mildly elevated creatine phosphokinase (HP:0008180)1.63043882
160Short humerus (HP:0005792)1.62438818
161J-shaped sella turcica (HP:0002680)1.62129787
162Elfin facies (HP:0004428)1.61971145
163Fragile skin (HP:0001030)1.61800817
164Fibroma (HP:0010614)1.61725001
165Limb hypertonia (HP:0002509)1.61006981
166Blue sclerae (HP:0000592)1.60309063
167Ankyloglossia (HP:0010296)1.60249724
168Long eyelashes (HP:0000527)1.59728524
169Atelectasis (HP:0100750)1.59587435
170Abnormal hand bone ossification (HP:0010660)1.59496897
171Overlapping toe (HP:0001845)1.59179101
172Natal tooth (HP:0000695)1.59162257
173Spinal cord compression (HP:0002176)1.58279853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D6.12444272
2TRIB34.74957289
3CAMK1G4.61891920
4SIK14.54222785
5SMG13.44002428
6ICK3.24279626
7EPHA23.10194083
8IRAK33.08125111
9DDR22.52903857
10BCKDK2.45253997
11RIPK12.36167983
12PDGFRA2.14197440
13PKN22.11287873
14TYRO31.87337984
15MAP3K61.86711561
16EEF2K1.70868166
17CDK121.69366838
18PDK41.63642359
19PDK31.63642359
20LATS21.61897710
21BMX1.54689437
22FGFR21.49788097
23LATS11.49165172
24CDK61.46956108
25PRKAA21.38383464
26ERN11.34945158
27PAK41.21208759
28IRAK21.17672473
29MAP3K101.14458735
30* MTOR1.13991924
31LMTK21.13801106
32PRKD31.13251834
33MST1R1.11207561
34RPS6KB21.09621905
35PRPF4B1.07449871
36FGFR41.02200692
37PRKAA10.99433372
38ARAF0.99123374
39PHKG20.98552537
40PHKG10.98552537
41PRKCI0.96826982
42PDGFRB0.95946692
43PTK60.93058598
44GSK3A0.92245677
45TNK20.92192193
46TTN0.87704563
47MET0.85880368
48FGFR10.84775337
49PRKD20.84621671
50FGR0.83387269
51FGFR30.80873654
52RET0.79506092
53MAP3K110.77744925
54PIM20.76580931
55PAK20.74296808
56CSK0.73504768
57TESK10.73321015
58MAPK110.73176666
59CDK90.72735386
60NME20.72079782
61SCYL20.71411635
62RPS6KA20.71130416
63DAPK10.70926892
64DAPK20.68149796
65EPHB20.67314213
66ALK0.65811200
67PDK20.64820772
68MAPKAPK30.64236414
69MATK0.62920708
70CDK40.62538269
71PAK60.61880020
72PINK10.61484949
73BRAF0.58491360
74MARK20.55304211
75DYRK1B0.54200146
76PTK20.54076525
77MAP2K20.52132135
78MAP3K90.50050205
79UHMK10.49005221
80PRKCH0.47958198
81FER0.47437162
82MAP3K80.46124152
83PRKACG0.46122150
84BRD40.45651272
85JAK20.44605164
86PRKD10.43383358
87PRKG20.43283458
88MAPK150.42693652
89KSR20.42521784
90FLT30.40945135
91MAP3K70.40792194
92EPHB10.40654734
93AKT20.40430880
94RPS6KB10.39867051
95MAP2K10.39209317
96CDC42BPA0.39080381
97INSR0.38780813
98RPS6KA10.38754987
99NTRK10.38206489
100ILK0.38172128
101PDPK10.37729694
102LRRK20.37578712
103TAOK10.36549801
104PRKCZ0.36142253
105INSRR0.35954653
106TTK0.35435715
107CHEK10.35076988
108TRPM70.34863437
109TESK20.34825253
110CDK70.34639850
111CHEK20.33855530
112AURKA0.33694956
113HIPK20.33505906
114CDK10.33479737
115MARK10.32973544
116CSNK1G10.32668257
117MAPK80.32373762
118RPS6KC10.32240543
119RPS6KL10.32240543
120IRAK10.31749136
121SIK20.31077412
122STK30.30492328
123FRK0.30418003
124GSK3B0.30378282
125MAP3K10.30318420
126TAOK20.29777472
127CDK20.29440684
128CAMK10.28378765
129CAMKK10.27665290
130STK110.27649374
131IRAK40.26859220
132EGFR0.26680428
133CHUK0.26465516
134AKT10.26111192
135WNK40.26042260
136RPS6KA30.25967810
137PDK10.25565622
138MAPK100.24784479
139SRC0.24598821
140JAK10.24467678
141MAPK140.23293446
142WNK10.23074826
143SGK30.21792084
144RPS6KA60.21353396

Predicted pathways (KEGG)

RankGene SetZ-score
1* Fatty acid biosynthesis_Homo sapiens_hsa000615.04820392
2Propanoate metabolism_Homo sapiens_hsa006403.80709334
3* Fatty acid metabolism_Homo sapiens_hsa012123.40798518
4PPAR signaling pathway_Homo sapiens_hsa033203.32373354
5Nitrogen metabolism_Homo sapiens_hsa009102.93046935
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.82375141
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.78898248
8Fatty acid degradation_Homo sapiens_hsa000712.71085793
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.57343802
10Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.53959472
11Pyruvate metabolism_Homo sapiens_hsa006202.43407377
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.21947830
13Glycerolipid metabolism_Homo sapiens_hsa005612.15840089
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.98352863
15Arginine biosynthesis_Homo sapiens_hsa002201.82132895
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.76362578
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.73185238
18Carbon metabolism_Homo sapiens_hsa012001.71964167
19Butanoate metabolism_Homo sapiens_hsa006501.67676367
20* AMPK signaling pathway_Homo sapiens_hsa041521.64308297
21Fat digestion and absorption_Homo sapiens_hsa049751.63284769
22Caffeine metabolism_Homo sapiens_hsa002321.57468725
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.51619603
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.47236369
25beta-Alanine metabolism_Homo sapiens_hsa004101.43896069
26Lysine degradation_Homo sapiens_hsa003101.42469440
27Tryptophan metabolism_Homo sapiens_hsa003801.42329551
28Biosynthesis of amino acids_Homo sapiens_hsa012301.41217709
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33145854
30Fatty acid elongation_Homo sapiens_hsa000621.27399235
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21722663
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20293487
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18555527
34Peroxisome_Homo sapiens_hsa041461.18414815
35Insulin resistance_Homo sapiens_hsa049311.18289733
36* Insulin signaling pathway_Homo sapiens_hsa049101.15720555
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08090317
38mTOR signaling pathway_Homo sapiens_hsa041501.07266535
39ErbB signaling pathway_Homo sapiens_hsa040121.05563104
40Prostate cancer_Homo sapiens_hsa052151.05455555
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04950094
42Central carbon metabolism in cancer_Homo sapiens_hsa052301.02363072
43Glucagon signaling pathway_Homo sapiens_hsa049221.01475268
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99570188
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98901047
46Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98067534
47Complement and coagulation cascades_Homo sapiens_hsa046100.92491481
48Phenylalanine metabolism_Homo sapiens_hsa003600.88967860
49Tyrosine metabolism_Homo sapiens_hsa003500.83761598
50DNA replication_Homo sapiens_hsa030300.83340335
51Pentose phosphate pathway_Homo sapiens_hsa000300.82832086
52Prion diseases_Homo sapiens_hsa050200.80698610
53Thyroid hormone synthesis_Homo sapiens_hsa049180.79490255
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78999888
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77843491
56Bile secretion_Homo sapiens_hsa049760.77057841
57Axon guidance_Homo sapiens_hsa043600.77056777
58N-Glycan biosynthesis_Homo sapiens_hsa005100.75732751
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71675938
60One carbon pool by folate_Homo sapiens_hsa006700.71030177
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70717858
62ABC transporters_Homo sapiens_hsa020100.69918432
63Adherens junction_Homo sapiens_hsa045200.68501755
64Starch and sucrose metabolism_Homo sapiens_hsa005000.67432337
65Renal cell carcinoma_Homo sapiens_hsa052110.67019161
66Renin-angiotensin system_Homo sapiens_hsa046140.66290482
67mRNA surveillance pathway_Homo sapiens_hsa030150.66241757
68Melanogenesis_Homo sapiens_hsa049160.66079516
69Other glycan degradation_Homo sapiens_hsa005110.65738240
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65611661
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65464374
72Staphylococcus aureus infection_Homo sapiens_hsa051500.65331325
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64433764
74Pancreatic cancer_Homo sapiens_hsa052120.62118474
75Choline metabolism in cancer_Homo sapiens_hsa052310.60602477
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59245001
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58620298
78Vibrio cholerae infection_Homo sapiens_hsa051100.58233505
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58071917
80Inositol phosphate metabolism_Homo sapiens_hsa005620.56450171
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.56067233
82GnRH signaling pathway_Homo sapiens_hsa049120.55635740
83ECM-receptor interaction_Homo sapiens_hsa045120.55050269
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54648592
85Focal adhesion_Homo sapiens_hsa045100.54402138
86Hippo signaling pathway_Homo sapiens_hsa043900.53558679
87Selenocompound metabolism_Homo sapiens_hsa004500.52059438
88Vitamin B6 metabolism_Homo sapiens_hsa007500.51893819
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.51745960
90Prolactin signaling pathway_Homo sapiens_hsa049170.51644584
91Long-term potentiation_Homo sapiens_hsa047200.50753845
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.50438006
93Steroid biosynthesis_Homo sapiens_hsa001000.50298134
94Vitamin digestion and absorption_Homo sapiens_hsa049770.49141497
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48453397
96Sulfur relay system_Homo sapiens_hsa041220.48118751
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48116900
98Type II diabetes mellitus_Homo sapiens_hsa049300.48014752
99Base excision repair_Homo sapiens_hsa034100.47916775
100Basal cell carcinoma_Homo sapiens_hsa052170.45462676
101Acute myeloid leukemia_Homo sapiens_hsa052210.42627113
102Endometrial cancer_Homo sapiens_hsa052130.41873125
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.41322838
104Small cell lung cancer_Homo sapiens_hsa052220.41141871
105Proteoglycans in cancer_Homo sapiens_hsa052050.40435874
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39683660
107Chronic myeloid leukemia_Homo sapiens_hsa052200.39424505
108Notch signaling pathway_Homo sapiens_hsa043300.38924694
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38106348
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37916994
111Chemical carcinogenesis_Homo sapiens_hsa052040.36005628
112Fructose and mannose metabolism_Homo sapiens_hsa000510.35011143
113VEGF signaling pathway_Homo sapiens_hsa043700.33788312
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.33465877
115Tight junction_Homo sapiens_hsa045300.32232655
116Thyroid cancer_Homo sapiens_hsa052160.31121878
117Bladder cancer_Homo sapiens_hsa052190.31011777
118Arginine and proline metabolism_Homo sapiens_hsa003300.30503139
119Retinol metabolism_Homo sapiens_hsa008300.29394134
120Viral myocarditis_Homo sapiens_hsa054160.28839296
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28577453
122TGF-beta signaling pathway_Homo sapiens_hsa043500.27695293
123Hedgehog signaling pathway_Homo sapiens_hsa043400.27526579
124Renin secretion_Homo sapiens_hsa049240.26589473
125Dorso-ventral axis formation_Homo sapiens_hsa043200.24340834
126Amoebiasis_Homo sapiens_hsa051460.23526306
127HIF-1 signaling pathway_Homo sapiens_hsa040660.22977258
128Galactose metabolism_Homo sapiens_hsa000520.22703146
129Protein digestion and absorption_Homo sapiens_hsa049740.22626095
130Glioma_Homo sapiens_hsa052140.21287759
131Estrogen signaling pathway_Homo sapiens_hsa049150.20216161
132Non-small cell lung cancer_Homo sapiens_hsa052230.19709548
133Colorectal cancer_Homo sapiens_hsa052100.19310862
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18761767
135MicroRNAs in cancer_Homo sapiens_hsa052060.17985131

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