FASTK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)7.49175038
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.90809332
3cardiac myofibril assembly (GO:0055003)6.71582990
4tricarboxylic acid cycle (GO:0006099)6.69986797
5negative regulation of potassium ion transmembrane transport (GO:1901380)6.36978818
6myofibril assembly (GO:0030239)5.99719890
7actin-myosin filament sliding (GO:0033275)5.98981974
8muscle filament sliding (GO:0030049)5.98981974
9plasma membrane repair (GO:0001778)5.82223423
10cardiac muscle contraction (GO:0060048)5.70384293
11carnitine shuttle (GO:0006853)5.64094812
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.16095383
13regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.03574774
14regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.03087028
15cardiac muscle cell development (GO:0055013)5.00733178
16regulation of skeletal muscle contraction (GO:0014819)4.98882115
17regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.88315958
18fatty acid transmembrane transport (GO:1902001)4.88024832
19NADH metabolic process (GO:0006734)4.84371488
20mannose metabolic process (GO:0006013)4.83982865
21actomyosin structure organization (GO:0031032)4.83122257
22ventricular cardiac muscle cell action potential (GO:0086005)4.79871991
232-oxoglutarate metabolic process (GO:0006103)4.77861906
24COPI coating of Golgi vesicle (GO:0048205)4.76954455
25Golgi transport vesicle coating (GO:0048200)4.76954455
26regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.76725344
27actin-mediated cell contraction (GO:0070252)4.74351036
28cardiac cell development (GO:0055006)4.66105122
29regulation of actin filament-based movement (GO:1903115)4.58327579
30striated muscle contraction (GO:0006941)4.58263307
31lysine metabolic process (GO:0006553)4.47251947
32lysine catabolic process (GO:0006554)4.47251947
33carnitine transmembrane transport (GO:1902603)4.44504995
34regulation of acyl-CoA biosynthetic process (GO:0050812)4.44193453
35cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.43212489
36creatine metabolic process (GO:0006600)4.29727566
37amino-acid betaine transport (GO:0015838)4.26938692
38carnitine transport (GO:0015879)4.26938692
39negative regulation of erythrocyte differentiation (GO:0045647)4.25974972
40heart trabecula formation (GO:0060347)4.23312370
41regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.22467576
42cardiac muscle hypertrophy (GO:0003300)4.21138813
43regulation of relaxation of muscle (GO:1901077)4.20337997
44regulation of cofactor metabolic process (GO:0051193)4.19164269
45regulation of coenzyme metabolic process (GO:0051196)4.19164269
46aspartate family amino acid catabolic process (GO:0009068)4.18167259
47cardiac muscle tissue morphogenesis (GO:0055008)4.14935822
48tricarboxylic acid metabolic process (GO:0072350)4.13802352
49bundle of His cell to Purkinje myocyte communication (GO:0086069)4.13261272
50oxaloacetate metabolic process (GO:0006107)4.12036502
51adult heart development (GO:0007512)4.11044458
52regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.08569174
53striated muscle hypertrophy (GO:0014897)4.05213277
54sarcoplasmic reticulum calcium ion transport (GO:0070296)4.04602499
55cell communication involved in cardiac conduction (GO:0086065)3.97097608
56GDP-mannose metabolic process (GO:0019673)3.96863088
57regulation of membrane repolarization (GO:0060306)3.96039994
58regulation of fatty acid oxidation (GO:0046320)3.94439816
59oxidative phosphorylation (GO:0006119)3.93460944
60ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.90124295
61cell communication by electrical coupling (GO:0010644)3.90115888
62protein retention in ER lumen (GO:0006621)3.81079023
63retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.80105285
64negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.76204520
65muscle tissue morphogenesis (GO:0060415)3.74537926
66succinate metabolic process (GO:0006105)3.73694017
67regulation of the force of heart contraction (GO:0002026)3.73533778
68fatty acid beta-oxidation (GO:0006635)3.71944872
69actin filament-based movement (GO:0030048)3.67386937
70NIK/NF-kappaB signaling (GO:0038061)3.66360658
71proline biosynthetic process (GO:0006561)3.65172436
72negative regulation of cell size (GO:0045792)3.63357231
73heart contraction (GO:0060047)3.62153826
74heart process (GO:0003015)3.62153826
75regulation of striated muscle contraction (GO:0006942)3.60284471
76negative regulation of potassium ion transport (GO:0043267)3.58432985
77regulation of sarcomere organization (GO:0060297)3.52879330
78maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.49300176
79muscle hypertrophy (GO:0014896)3.47029522
80cardiac muscle cell action potential involved in contraction (GO:0086002)3.40838414
81valine metabolic process (GO:0006573)3.35466135
82regulation of sequestering of triglyceride (GO:0010889)3.35227659
83cardiac muscle cell action potential (GO:0086001)3.32467363
84mitochondrial fusion (GO:0008053)3.31833922
85cardiac muscle hypertrophy in response to stress (GO:0014898)3.29928409
86muscle hypertrophy in response to stress (GO:0003299)3.29928409
87cardiac muscle adaptation (GO:0014887)3.29928409
88UV protection (GO:0009650)3.29733350
894-hydroxyproline metabolic process (GO:0019471)3.25132548
90regulation of ATP catabolic process (GO:1903289)3.23984332
91regulation of ATPase activity (GO:0043462)3.23984332
92regulation of cell communication by electrical coupling (GO:0010649)3.23721653
93quaternary ammonium group transport (GO:0015697)3.23283685
94regulation of sulfur metabolic process (GO:0042762)3.19470180
95regulation of mammary gland epithelial cell proliferation (GO:0033599)3.16590035
96acetyl-CoA metabolic process (GO:0006084)3.16001078
97skeletal muscle contraction (GO:0003009)3.13933753
98barbed-end actin filament capping (GO:0051016)3.12759907
99muscle contraction (GO:0006936)3.11290247
100apoptotic process involved in morphogenesis (GO:0060561)3.10683053
101regulation of heart rate (GO:0002027)3.09846150
102positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.08957997
103glycogen catabolic process (GO:0005980)3.08680524
104fatty acid catabolic process (GO:0009062)3.05668928
105basement membrane organization (GO:0071711)3.04962917
106regulation of necrotic cell death (GO:0010939)3.02710699
107cell-substrate adherens junction assembly (GO:0007045)3.01653166
108focal adhesion assembly (GO:0048041)3.01653166
109adherens junction assembly (GO:0034333)3.01031483
110positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.00831101
111striated muscle cell development (GO:0055002)3.00470410
112branched-chain amino acid catabolic process (GO:0009083)3.00026162
113regulation of cardiac muscle cell contraction (GO:0086004)2.98995209
114branched-chain amino acid metabolic process (GO:0009081)2.98860447
115gluconeogenesis (GO:0006094)2.97531479
116regulation of extracellular matrix disassembly (GO:0010715)2.97481216
117negative regulation of nucleotide catabolic process (GO:0030812)2.95870168
118protein localization to endosome (GO:0036010)2.94025450
119regulation of tight junction assembly (GO:2000810)2.94001245
120striated muscle adaptation (GO:0014888)2.93342758
121fatty acid oxidation (GO:0019395)2.92262335
122negative regulation of cytosolic calcium ion concentration (GO:0051481)2.91471693
123regulation of early endosome to late endosome transport (GO:2000641)2.90491600
124glucan catabolic process (GO:0009251)2.88708990
125positive regulation of Cdc42 GTPase activity (GO:0043089)2.84421799
126pinocytosis (GO:0006907)2.83119564
127negative regulation of necroptotic process (GO:0060546)2.78613342
128activation of Rac GTPase activity (GO:0032863)2.75746683
129regulation of glucose import in response to insulin stimulus (GO:2001273)2.73151147
130activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.72503238
131protein maturation by protein folding (GO:0022417)2.72399472
132antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.68546136
133modulation by symbiont of host cellular process (GO:0044068)2.68506434
134proline metabolic process (GO:0006560)2.66962546
135positive regulation of triglyceride lipase activity (GO:0061365)2.66856156
136positive regulation of lipoprotein lipase activity (GO:0051006)2.66856156
137modulation by virus of host process (GO:0019054)2.65971715
138regulation of necroptotic process (GO:0060544)2.64760746
139antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.62200121
140negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.62155895
141positive regulation of nuclease activity (GO:0032075)2.60614739
142regulation of ARF GTPase activity (GO:0032312)2.60611875
143antigen processing and presentation of endogenous antigen (GO:0019883)2.60025117
144pentose-phosphate shunt (GO:0006098)2.59136354
145maternal placenta development (GO:0001893)2.58779122
146endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.58366490
147retrograde transport, endosome to Golgi (GO:0042147)2.55612942
148semaphorin-plexin signaling pathway (GO:0071526)2.55560163
149negative regulation of necrotic cell death (GO:0060547)2.54546903
150regulation of cholesterol metabolic process (GO:0090181)2.53903093
151positive regulation of protein dephosphorylation (GO:0035307)2.53435890
152positive thymic T cell selection (GO:0045059)2.53064562
153activation of MAPKKK activity (GO:0000185)2.49142692
154glucose catabolic process (GO:0006007)2.48255686
155activation of JUN kinase activity (GO:0007257)2.48062002
156positive regulation of myotube differentiation (GO:0010831)2.47689075
157regulation of type I interferon-mediated signaling pathway (GO:0060338)2.44313925
158vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.43258657
159actin filament depolymerization (GO:0030042)2.42844827
160thymic T cell selection (GO:0045061)2.41971388
161cell-substrate junction assembly (GO:0007044)2.40262321
162stress fiber assembly (GO:0043149)2.39408533
163urea cycle (GO:0000050)2.38972280
164monosaccharide biosynthetic process (GO:0046364)2.38287104
165positive regulation of receptor recycling (GO:0001921)2.37909214
166negative regulation of viral release from host cell (GO:1902187)2.37105768
167response to laminar fluid shear stress (GO:0034616)2.35036004
168cellular response to virus (GO:0098586)2.33340060
169glucose 6-phosphate metabolic process (GO:0051156)2.31988129
170hexose biosynthetic process (GO:0019319)2.31530397
171regulation of nuclease activity (GO:0032069)2.30353701
172positive regulation of blood vessel endothelial cell migration (GO:0043536)2.28041658
173atrioventricular valve morphogenesis (GO:0003181)2.27672815
174endothelial cell chemotaxis (GO:0035767)2.27479744
175Arp2/3 complex-mediated actin nucleation (GO:0034314)2.26800942
176regulation of cholesterol biosynthetic process (GO:0045540)2.25740573
177fructose metabolic process (GO:0006000)2.24984053
178nitrogen cycle metabolic process (GO:0071941)2.24641071
179endoplasmic reticulum unfolded protein response (GO:0030968)2.23090765
180embryo implantation (GO:0007566)2.22892616
181response to peptidoglycan (GO:0032494)2.22030472
182positive regulation of histone deacetylation (GO:0031065)2.21085741
183epithelial cell differentiation involved in prostate gland development (GO:0060742)2.19349918
184glutamine family amino acid biosynthetic process (GO:0009084)2.18972014
185protein targeting to plasma membrane (GO:0072661)2.18725894
186negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.18689929
187negative regulation of cell killing (GO:0031342)2.18556743
188negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.18556743
189modulation by virus of host morphology or physiology (GO:0019048)2.18154027
190adhesion of symbiont to host (GO:0044406)2.17990278
1913-UTR-mediated mRNA stabilization (GO:0070935)2.17961093
192urea metabolic process (GO:0019627)2.17618876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.86430111
2TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.30815213
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.12992178
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.10137708
5ZNF263_19887448_ChIP-Seq_K562_Human2.83326262
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.54095287
7LXR_22292898_ChIP-Seq_THP-1_Human2.49505889
8* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.39450480
9TBX20_22328084_ChIP-Seq_HEART_Mouse2.34677401
10TBX20_22080862_ChIP-Seq_HEART_Mouse2.34677401
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.34232747
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.33108303
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.28857758
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15482589
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.12145686
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09863308
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.07140745
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.05722843
19MYC_22102868_ChIP-Seq_BL_Human2.04377358
20KDM2B_26808549_Chip-Seq_DND41_Human2.02942516
21NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.93508728
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.87517943
23P68_20966046_ChIP-Seq_HELA_Human1.86745151
24RACK7_27058665_Chip-Seq_MCF-7_Human1.86031451
25ZFP281_18757296_ChIP-ChIP_E14_Mouse1.78103941
26CLOCK_20551151_ChIP-Seq_293T_Human1.73795066
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72673120
28* VDR_21846776_ChIP-Seq_THP-1_Human1.69092624
29CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.65755147
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60439009
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.59909894
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.58743681
33VDR_24763502_ChIP-Seq_THP-1_Human1.58388535
34ATF3_27146783_Chip-Seq_COLON_Human1.56025490
35TCF7_22412390_ChIP-Seq_EML_Mouse1.55743669
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.55007841
37LXR_22158963_ChIP-Seq_LIVER_Mouse1.54227103
38ELF1_20517297_ChIP-Seq_JURKAT_Human1.52542379
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52460827
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51948437
41* MAF_26560356_Chip-Seq_TH2_Human1.47880392
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.47871965
43MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.47366958
44* BCL6_27268052_Chip-Seq_Bcells_Human1.45972190
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.45837194
46* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45005896
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.44702683
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.43847431
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.42982658
50CTCF_27219007_Chip-Seq_Bcells_Human1.40903031
51* BCOR_27268052_Chip-Seq_Bcells_Human1.39860487
52* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39636914
53KDM2B_26808549_Chip-Seq_K562_Human1.39148332
54CREB1_26743006_Chip-Seq_LNCaP_Human1.39116116
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38893735
56* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.38693826
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36659750
58* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35691025
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34194355
60TP63_22573176_ChIP-Seq_HFKS_Human1.34145127
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34034821
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33253403
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.31911316
64YY1_22570637_ChIP-Seq_MALME-3M_Human1.31848913
65SMC4_20622854_ChIP-Seq_HELA_Human1.31819364
66CTCF_21964334_ChIP-Seq_BJAB-B_Human1.31193978
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.30633107
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30107901
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29081614
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28341004
71RUNX1_22412390_ChIP-Seq_EML_Mouse1.28296719
72GATA4_21415370_ChIP-Seq_HL-1_Mouse1.27885637
73NCOR1_26117541_ChIP-Seq_K562_Human1.26596252
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26536301
75CTCF_21964334_Chip-Seq_Bcells_Human1.26535092
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26244672
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26131741
78SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24318855
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22711125
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22269048
81CTCF_26484167_Chip-Seq_Bcells_Mouse1.22117485
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21874889
83E2F1_20622854_ChIP-Seq_HELA_Human1.21711951
84NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.21498608
85SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20461521
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19956394
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18662024
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18560414
89BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18285133
90PHF8_20622854_ChIP-Seq_HELA_Human1.17500138
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17256757
92TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.14353865
93EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13824317
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13262389
95SA1_27219007_Chip-Seq_Bcells_Human1.12335361
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10974055
97SPI1_20517297_ChIP-Seq_HL60_Human1.10391622
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10274518
99RARB_24833708_ChIP-Seq_LIVER_Mouse1.10195493
100CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10180937
101ETS1_21867929_ChIP-Seq_TH2_Mouse1.09740098
102MAF_26560356_Chip-Seq_TH1_Human1.09377145
103GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.08547998
104E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08162450
105TP53_22127205_ChIP-Seq_IMR90_Human1.07522160
106MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07516903
107RUNX1_27514584_Chip-Seq_MCF-7_Human1.06908120
108RARA_24833708_ChIP-Seq_LIVER_Mouse1.06847962
109GATA1_19941827_ChIP-Seq_MEL_Mouse1.06560797
110SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05731756
111* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05640596
112CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05047644
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04952002
114* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04708338
115MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04092836
116KDM2B_26808549_Chip-Seq_JURKAT_Human1.03940607
117GATA1_19941826_ChIP-Seq_K562_Human1.02904727
118* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02676932
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02424894
120SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02204214
121PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02130590
122DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99768948
123* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98593211
124KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98008119
125CIITA_25753668_ChIP-Seq_RAJI_Human0.95697339
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94033694
127FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93747281
128FOXP1_21924763_ChIP-Seq_HESCs_Human0.93389296
129UTX_26944678_Chip-Seq_JUKART_Human0.93356385
130TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92791498

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.86613371
2MP0003646_muscle_fatigue5.81272081
3MP0000751_myopathy4.97749084
4MP0004084_abnormal_cardiac_muscle4.74716383
5MP0005058_abnormal_lysosome_morphology4.03190190
6MP0004036_abnormal_muscle_relaxation3.85207320
7MP0004215_abnormal_myocardial_fiber3.77560897
8MP0000749_muscle_degeneration3.69069014
9MP0005330_cardiomyopathy3.42256686
10MP0004087_abnormal_muscle_fiber3.04390382
11MP0004130_abnormal_muscle_cell2.71939737
12MP0000750_abnormal_muscle_regeneration2.70220404
13MP0002269_muscular_atrophy2.67710277
14MP0008260_abnormal_autophagy2.57953180
15MP0002106_abnormal_muscle_physiology2.54004478
16MP0002972_abnormal_cardiac_muscle2.51344567
17MP0008775_abnormal_heart_ventricle2.47212102
18MP0003137_abnormal_impulse_conducting2.39605954
19MP0005620_abnormal_muscle_contractility2.39601177
20MP0004233_abnormal_muscle_weight2.38025171
21MP0010630_abnormal_cardiac_muscle2.36320147
22MP0000747_muscle_weakness2.35288045
23MP0004145_abnormal_muscle_electrophysio2.32883337
24MP0005385_cardiovascular_system_phenoty2.22995954
25MP0001544_abnormal_cardiovascular_syste2.22995954
26MP0003172_abnormal_lysosome_physiology2.19004316
27MP0000759_abnormal_skeletal_muscle2.11424236
28MP0003436_decreased_susceptibility_to2.06273828
29MP0005670_abnormal_white_adipose2.04029039
30MP0005369_muscle_phenotype2.02858909
31MP0003705_abnormal_hypodermis_morpholog1.90232178
32MP0006138_congestive_heart_failure1.89159342
33MP0006036_abnormal_mitochondrial_physio1.88323083
34MP0005666_abnormal_adipose_tissue1.85770546
35MP0004484_altered_response_of1.85403980
36MP0003221_abnormal_cardiomyocyte_apopto1.79375516
37MP0003303_peritoneal_inflammation1.76650487
38MP0002877_abnormal_melanocyte_morpholog1.69289316
39MP0004085_abnormal_heartbeat1.59466832
40MP0005076_abnormal_cell_differentiation1.57386609
41MP0000858_altered_metastatic_potential1.54460809
42MP0000678_abnormal_parathyroid_gland1.52350008
43MP0009278_abnormal_bone_marrow1.48985729
44MP0004510_myositis1.47946317
45MP0003453_abnormal_keratinocyte_physiol1.47218145
46MP0003828_pulmonary_edema1.45554177
47MP0004947_skin_inflammation1.44094801
48MP0009384_cardiac_valve_regurgitation1.41173723
49MP0001958_emphysema1.40308651
50MP0002332_abnormal_exercise_endurance1.40128782
51MP0001873_stomach_inflammation1.38671987
52MP0003806_abnormal_nucleotide_metabolis1.38615409
53MP0005375_adipose_tissue_phenotype1.38448023
54MP0009840_abnormal_foam_cell1.37922587
55MP0004185_abnormal_adipocyte_glucose1.35157265
56MP0009333_abnormal_splenocyte_physiolog1.34842022
57MP0005409_darkened_coat_color1.31297315
58MP0003763_abnormal_thymus_physiology1.27303700
59MP0010234_abnormal_vibrissa_follicle1.23458814
60MP0002127_abnormal_cardiovascular_syste1.23155452
61MP0003091_abnormal_cell_migration1.22406109
62MP0008961_abnormal_basal_metabolism1.21824980
63MP0001348_abnormal_lacrimal_gland1.20245127
64MP0000266_abnormal_heart_morphology1.15834399
65MP0002234_abnormal_pharynx_morphology1.15577240
66MP0000685_abnormal_immune_system1.15328263
67MP0002249_abnormal_larynx_morphology1.11253143
68MP0003567_abnormal_fetal_cardiomyocyte1.10378310
69MP0004381_abnormal_hair_follicle1.09238290
70MP0002933_joint_inflammation1.09067360
71MP0004043_abnormal_pH_regulation1.08827722
72MP0002909_abnormal_adrenal_gland1.06361027
73MP0003279_aneurysm1.05585617
74MP0005025_abnormal_response_to1.05214503
75MP0003075_altered_response_to1.05130294
76MP0001661_extended_life_span1.04836908
77MP0005257_abnormal_intraocular_pressure1.03470506
78MP0000003_abnormal_adipose_tissue1.02022831
79MP0005266_abnormal_metabolism1.01969495
80MP0010155_abnormal_intestine_physiology1.01490712
81MP0006035_abnormal_mitochondrial_morpho1.00833009
82MP0001533_abnormal_skeleton_physiology0.97657036
83MP0002060_abnormal_skin_morphology0.97645462
84MP0003300_gastrointestinal_ulcer0.96111479
85MP0005501_abnormal_skin_physiology0.94579460
86MP0002796_impaired_skin_barrier0.94494602
87MP0002998_abnormal_bone_remodeling0.93411365
88MP0003566_abnormal_cell_adhesion0.92028356
89MP0005023_abnormal_wound_healing0.91439747
90MP0005464_abnormal_platelet_physiology0.88334074
91MP0000604_amyloidosis0.87868763
92MP0000767_abnormal_smooth_muscle0.87606461
93MP0005000_abnormal_immune_tolerance0.87556851
94MP0000343_altered_response_to0.87415404
95* MP0002419_abnormal_innate_immunity0.86832881
96MP0002971_abnormal_brown_adipose0.85644064
97MP0002108_abnormal_muscle_morphology0.84070958
98MP0000013_abnormal_adipose_tissue0.83283336
99MP0005166_decreased_susceptibility_to0.82645743
100MP0005083_abnormal_biliary_tract0.82642911
101MP0000681_abnormal_thyroid_gland0.82330241
102MP0005319_abnormal_enzyme/_coenzyme0.81929908
103MP0004272_abnormal_basement_membrane0.81054062
104MP0005332_abnormal_amino_acid0.80729056
105MP0005387_immune_system_phenotype0.80681100
106MP0001790_abnormal_immune_system0.80681100
107MP0000733_abnormal_muscle_development0.78896264
108MP0001853_heart_inflammation0.78642108
109MP0002396_abnormal_hematopoietic_system0.77862292
110MP0005165_increased_susceptibility_to0.77265800
111MP0001243_abnormal_dermal_layer0.76948009
112MP0009931_abnormal_skin_appearance0.76839588
113MP0002078_abnormal_glucose_homeostasis0.75580904
114MP0005360_urolithiasis0.74119234
115MP0001835_abnormal_antigen_presentation0.72208812
116MP0003950_abnormal_plasma_membrane0.70922217
117MP0005365_abnormal_bile_salt0.70770586
118MP0005621_abnormal_cell_physiology0.70716246
119MP0006082_CNS_inflammation0.69655101
120MP0002128_abnormal_blood_circulation0.69376583
121MP0010368_abnormal_lymphatic_system0.69177638
122* MP0001819_abnormal_immune_cell0.66971446
123MP0000230_abnormal_systemic_arterial0.65839523
124MP0002118_abnormal_lipid_homeostasis0.65066329
125MP0005085_abnormal_gallbladder_physiolo0.64236938
126MP0002653_abnormal_ependyma_morphology0.64200863
127MP0002970_abnormal_white_adipose0.63463233
128MP0005584_abnormal_enzyme/coenzyme_acti0.60271692
129MP0005275_abnormal_skin_tensile0.59391353
130MP0009643_abnormal_urine_homeostasis0.56899813
131MP0005623_abnormal_meninges_morphology0.56515864
132MP0009115_abnormal_fat_cell0.56429825
133MP0003984_embryonic_growth_retardation0.56045385
134MP0002822_catalepsy0.55700674
135MP0005334_abnormal_fat_pad0.55027864
136MP0008438_abnormal_cutaneous_collagen0.54846178
137MP0002088_abnormal_embryonic_growth/wei0.54804441
138MP0002089_abnormal_postnatal_growth/wei0.54486576
139MP0010329_abnormal_lipoprotein_level0.53561330
140MP0004858_abnormal_nervous_system0.53387005
141MP0003191_abnormal_cellular_cholesterol0.53057123
142MP0003656_abnormal_erythrocyte_physiolo0.52044670
143MP0003283_abnormal_digestive_organ0.51252465
144MP0003329_amyloid_beta_deposits0.49872006
145MP0005535_abnormal_body_temperature0.48580689
146MP0005451_abnormal_body_composition0.48163830
147MP0000609_abnormal_liver_physiology0.48037126
148MP0002139_abnormal_hepatobiliary_system0.46466376
149MP0003195_calcinosis0.45353909
150MP0002925_abnormal_cardiovascular_devel0.43332415
151MP0001849_ear_inflammation0.42714701
152MP0001765_abnormal_ion_homeostasis0.41276197
153MP0001666_abnormal_nutrient_absorption0.41158828
154MP0009672_abnormal_birth_weight0.40971509
155MP0001672_abnormal_embryogenesis/_devel0.40265239

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.58335050
2Exercise-induced myalgia (HP:0003738)6.05140638
3Exercise-induced muscle cramps (HP:0003710)5.65843020
4Myoglobinuria (HP:0002913)5.49748040
5Ventricular tachycardia (HP:0004756)5.46149815
6Calf muscle hypertrophy (HP:0008981)5.25267218
7Muscle fiber splitting (HP:0003555)5.06504971
8Muscle hypertrophy of the lower extremities (HP:0008968)4.86539670
9Hyporeflexia of lower limbs (HP:0002600)4.59419549
10Atrial fibrillation (HP:0005110)4.39848968
11Abnormality of the calf musculature (HP:0001430)4.32649208
12Subaortic stenosis (HP:0001682)4.20810002
13Abnormality of the left ventricular outflow tract (HP:0011103)4.20810002
14Lipoatrophy (HP:0100578)4.19614735
15Primary atrial arrhythmia (HP:0001692)4.13858107
16Rhabdomyolysis (HP:0003201)4.12516491
17Increased connective tissue (HP:0009025)4.07237173
18Supraventricular tachycardia (HP:0004755)4.04054949
19Asymmetric septal hypertrophy (HP:0001670)4.02678335
20Bundle branch block (HP:0011710)4.01054033
21Difficulty running (HP:0009046)3.99058081
22Supraventricular arrhythmia (HP:0005115)3.97734999
23Right ventricular cardiomyopathy (HP:0011663)3.96948081
24EMG: myopathic abnormalities (HP:0003458)3.69709258
25Palpitations (HP:0001962)3.65684232
26Dilated cardiomyopathy (HP:0001644)3.60695758
27Syncope (HP:0001279)3.57516477
28Centrally nucleated skeletal muscle fibers (HP:0003687)3.48480692
29Prolonged QT interval (HP:0001657)3.38019521
30Difficulty climbing stairs (HP:0003551)3.35664630
31Atrioventricular block (HP:0001678)3.32744321
32Myotonia (HP:0002486)3.32740420
33Heart block (HP:0012722)3.31349793
34Vertebral compression fractures (HP:0002953)3.30729788
35Type 1 muscle fiber predominance (HP:0003803)3.29864347
36Ventricular arrhythmia (HP:0004308)3.28624038
37Ketoacidosis (HP:0001993)3.21733242
38Protrusio acetabuli (HP:0003179)3.20975373
39Ventricular fibrillation (HP:0001663)3.13911235
40Abnormal atrioventricular conduction (HP:0005150)3.11514780
41Muscle fiber inclusion bodies (HP:0100299)3.00174376
42Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.93508250
43Premature rupture of membranes (HP:0001788)2.90896334
44Hypoglycemic coma (HP:0001325)2.88308656
45Muscle stiffness (HP:0003552)2.84767519
46Stridor (HP:0010307)2.83165826
47Increased variability in muscle fiber diameter (HP:0003557)2.79594966
48Cerebral aneurysm (HP:0004944)2.79093884
49Achilles tendon contracture (HP:0001771)2.76615654
50Ketosis (HP:0001946)2.73567176
51J-shaped sella turcica (HP:0002680)2.72864685
52Abnormality of fatty-acid metabolism (HP:0004359)2.70867803
53Dysostosis multiplex (HP:0000943)2.70462525
54Bulbar palsy (HP:0001283)2.70329301
55Broad face (HP:0000283)2.65069210
56Limb-girdle muscle atrophy (HP:0003797)2.62051863
57Abnormality of skeletal muscle fiber size (HP:0012084)2.60011721
58Thin bony cortex (HP:0002753)2.59044616
59Biconcave vertebral bodies (HP:0004586)2.58628624
60Cervical subluxation (HP:0003308)2.58520292
61Hemorrhage of the eye (HP:0011885)2.57845557
62Abnormality of the Achilles tendon (HP:0005109)2.52583292
63Ragged-red muscle fibers (HP:0003200)2.50987541
64Ulnar bowing (HP:0003031)2.49710676
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.49387636
66Dicarboxylic aciduria (HP:0003215)2.49387636
67Abnormal EKG (HP:0003115)2.48513056
68Obstructive sleep apnea (HP:0002870)2.48242883
69Abnormal gallbladder physiology (HP:0012438)2.44296135
70Cholecystitis (HP:0001082)2.44296135
71Hyperacusis (HP:0010780)2.41137843
72Hepatic necrosis (HP:0002605)2.40335312
73Mildly elevated creatine phosphokinase (HP:0008180)2.37864963
74Abnormality of mucopolysaccharide metabolism (HP:0011020)2.30451807
75Abnormality of polysaccharide metabolism (HP:0011012)2.30451807
76Abnormality of glycosaminoglycan metabolism (HP:0004371)2.30451807
77Distal lower limb muscle weakness (HP:0009053)2.30322389
78Nemaline bodies (HP:0003798)2.29942283
79Easy fatigability (HP:0003388)2.28413030
80Joint stiffness (HP:0001387)2.27539555
81Urinary glycosaminoglycan excretion (HP:0003541)2.26337373
82Mucopolysacchariduria (HP:0008155)2.26337373
83EMG: neuropathic changes (HP:0003445)2.24296496
84Myopathic facies (HP:0002058)2.23619758
85Spinal rigidity (HP:0003306)2.23405988
86Neck muscle weakness (HP:0000467)2.20956391
87Broad metatarsal (HP:0001783)2.19795577
88Dysmetric saccades (HP:0000641)2.18362168
89Hyperglycinuria (HP:0003108)2.16636013
90Systemic lupus erythematosus (HP:0002725)2.15730621
91Colitis (HP:0002583)2.15710954
92Large for gestational age (HP:0001520)2.13593135
93Lower limb amyotrophy (HP:0007210)2.13186379
94Hyperammonemia (HP:0001987)2.12078235
95Hand muscle atrophy (HP:0009130)2.11498273
96Areflexia of lower limbs (HP:0002522)2.11462071
97Left ventricular hypertrophy (HP:0001712)2.10915681
98Testicular atrophy (HP:0000029)2.09316184
99Cholelithiasis (HP:0001081)2.09062623
100Conjunctival hamartoma (HP:0100780)2.09045305
101Increased muscle lipid content (HP:0009058)2.08989726
102Generalized amyotrophy (HP:0003700)2.07309341
103Gout (HP:0001997)2.06951364
104Progressive muscle weakness (HP:0003323)2.05399370
105Axonal loss (HP:0003447)2.00788722
106Generalized muscle weakness (HP:0003324)2.00429120
107Palmoplantar keratoderma (HP:0000982)1.98806951
108Athetosis (HP:0002305)1.97623945
109Eczematoid dermatitis (HP:0000976)1.97568639
110Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.94963042
111Nuclear cataract (HP:0100018)1.94275149
112Abnormality of liposaccharide metabolism (HP:0010968)1.93099598
113Abnormality of glycosphingolipid metabolism (HP:0004343)1.93099598
114Abnormality of glycolipid metabolism (HP:0010969)1.93099598
115Cellulitis (HP:0100658)1.92453310
116Hamartoma of the eye (HP:0010568)1.92171225
117Loss of speech (HP:0002371)1.92060371
118Growth hormone excess (HP:0000845)1.90569695
119Fragile skin (HP:0001030)1.90051809
120Facial diplegia (HP:0001349)1.89648552
121Malnutrition (HP:0004395)1.88756082
122Pheochromocytoma (HP:0002666)1.88034121
123Hypertriglyceridemia (HP:0002155)1.87598206
124Upper limb amyotrophy (HP:0009129)1.86836465
125Distal upper limb amyotrophy (HP:0007149)1.86836465
126Neoplasm of the adrenal gland (HP:0100631)1.86431083
127Hyperinsulinemic hypoglycemia (HP:0000825)1.85580838
128Mitral regurgitation (HP:0001653)1.84203693
129Abnormal mitochondria in muscle tissue (HP:0008316)1.83918960
130Distal arthrogryposis (HP:0005684)1.82639988
131Blue sclerae (HP:0000592)1.82508773
132Hepatocellular necrosis (HP:0001404)1.81946636
133Hypertensive crisis (HP:0100735)1.81830639
134Lymphangioma (HP:0100764)1.81825563
135Neonatal death (HP:0003811)1.81805427
136Emphysema (HP:0002097)1.81202619
137Abnormality of glycine metabolism (HP:0010895)1.79937112
138Abnormality of serine family amino acid metabolism (HP:0010894)1.79937112
139Increased serum ferritin (HP:0003281)1.79198149
140Multiple enchondromatosis (HP:0005701)1.78742701
141Abnormal gallbladder morphology (HP:0012437)1.78132889
142Ulnar deviation of the wrist (HP:0003049)1.77715787
143Round ear (HP:0100830)1.77237457
144Frequent falls (HP:0002359)1.76365075
145Late onset (HP:0003584)1.76052758
146Elbow flexion contracture (HP:0002987)1.75911361
147Abnormality of the foot musculature (HP:0001436)1.75535190
148Neoplasm of head and neck (HP:0012288)1.74723771
149Esophageal neoplasm (HP:0100751)1.74723771
150Gowers sign (HP:0003391)1.74362556
151Distal lower limb amyotrophy (HP:0008944)1.74147991
152Sudden cardiac death (HP:0001645)1.73424727
153Gastrointestinal inflammation (HP:0004386)1.70467122
154Reticulocytosis (HP:0001923)1.70369630
155Shallow orbits (HP:0000586)1.69828453
156Nonimmune hydrops fetalis (HP:0001790)1.68770104
157Increased cerebral lipofuscin (HP:0011813)1.68726206
158Thin ribs (HP:0000883)1.67561851
159Atrophic scars (HP:0001075)1.66586262
160Fatigue (HP:0012378)1.66376626
161Flat acetabular roof (HP:0003180)1.65315089
162Abnormality of the thoracic spine (HP:0100711)1.65206220
163Increased IgE level (HP:0003212)1.65168380
164Deep venous thrombosis (HP:0002625)1.64719778
165Purpura (HP:0000979)1.64414881
166Ankle clonus (HP:0011448)1.64036595
167Gastrointestinal stroma tumor (HP:0100723)1.63446730
168Disproportionate tall stature (HP:0001519)1.63372932
169Abnormality of complement system (HP:0005339)1.62232624
170Gastrointestinal dysmotility (HP:0002579)1.62075432
171Cerebral palsy (HP:0100021)1.61978377
172Turricephaly (HP:0000262)1.61279945

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.09385328
2TRIB34.52812671
3PKN23.83219026
4LMTK23.52232613
5BCKDK3.43093090
6PHKG23.32290762
7PHKG13.32290762
8PDK33.15280946
9PDK43.15280946
10OBSCN3.01286542
11PRPF4B2.91899458
12NEK12.82475449
13SMG12.56048049
14IRAK32.50847146
15NME22.48123011
16MYLK2.30910495
17DMPK2.15467012
18TESK11.96327502
19ERN11.90658335
20PDK21.85540141
21TESK21.82523140
22RIPK11.71372131
23PINK11.69791615
24EPHA21.67837138
25MAP3K101.61650409
26MAP4K11.58186215
27ICK1.54906889
28MAP3K71.49296867
29ARAF1.47499308
30PRKD31.47227576
31TBK11.44408103
32MST1R1.40663332
33PDGFRA1.36330528
34SIK11.27520053
35FLT31.19544835
36TAOK11.18569598
37MAP3K131.17301576
38TNK21.15106923
39MAP2K31.13318883
40MAPKAPK31.11787568
41RIPK41.11245250
42EEF2K1.10831212
43TYK21.07778314
44PIM21.07305712
45SCYL21.07226971
46ZAP701.06526168
47GRK61.03689352
48ILK1.01878000
49MAPK120.96901098
50WNK40.95462572
51MAP3K60.94809343
52TIE10.94123364
53PRKD10.92036157
54FGFR40.91987408
55CDC42BPA0.91065467
56MAP2K60.87990638
57LRRK20.86577199
58PRKAA10.86441252
59DAPK30.86279021
60CDK120.86264188
61PTK60.85916850
62MAP3K30.85061951
63MUSK0.83884611
64BLK0.82825388
65PIK3CA0.82566618
66MAP3K110.80243109
67PAK30.79270881
68MAP2K20.77991558
69LIMK10.77559105
70STK380.77445861
71MTOR0.72748976
72SIK30.72127701
73CAMK40.71337393
74KSR20.69520737
75CAMK2D0.62710446
76MAPK110.62165168
77NME10.62152704
78KDR0.60504024
79TYRO30.59861679
80BRAF0.58040266
81ROCK10.57279978
82CAMKK10.56664591
83CDK40.56214706
84MAP3K140.56096928
85MAPK70.54696869
86IRAK40.54363041
87MAP3K80.53113846
88RPS6KL10.52659143
89RPS6KC10.52659143
90HIPK20.52490629
91JAK30.52377994
92DDR20.52101726
93IRAK20.51975672
94CAMK10.51445344
95RPS6KA60.50558571
96PRKAA20.50238602
97RET0.50193273
98AKT20.50106442
99SGK30.49196561
100PDPK10.48995287
101ABL20.47809436
102PRKCH0.47012665
103SIK20.45618985
104DYRK1B0.45252146
105MAP3K50.43936693
106MOS0.43369536
107PDK10.43028438
108MAPK150.42955541
109PRKD20.42914188
110STK240.42808252
111LATS20.42273062
112TAOK20.41942523
113PAK60.41426108
114PRKG20.41397743
115DAPK10.40165609
116CSK0.39432071
117PTK2B0.38887498
118RPS6KA10.38820592
119DAPK20.37980290
120IKBKE0.37965895
121MET0.37454166
122MAP2K40.36429508
123MAPK40.36022914
124PAK40.35671758
125BMX0.35623841
126PRKACG0.35101373
127CAMK1D0.34516549
128EPHB10.33704613
129MAP3K10.33474971
130RPS6KA20.31362049
131MARK20.30589750
132MAP3K90.30260436
133UHMK10.29874696
134PRKACB0.29045677
135PTK20.27868682
136TGFBR20.27561103
137MAP3K40.27298145
138CAMK2G0.26110702
139ROCK20.25075198
140ALK0.25036882
141FGFR10.24313170
142STK40.22701845
143WNK10.21021192

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.80052142
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.79626067
3Other glycan degradation_Homo sapiens_hsa005114.19348064
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.63554366
5Propanoate metabolism_Homo sapiens_hsa006403.27890818
6Fatty acid degradation_Homo sapiens_hsa000713.10950977
7Cardiac muscle contraction_Homo sapiens_hsa042602.94131383
8Carbon metabolism_Homo sapiens_hsa012002.84401128
9Dilated cardiomyopathy_Homo sapiens_hsa054142.59055005
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.54947423
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.48650160
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.48611749
13Fatty acid metabolism_Homo sapiens_hsa012122.48089018
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.20970852
15Pyruvate metabolism_Homo sapiens_hsa006202.12798770
16Biosynthesis of amino acids_Homo sapiens_hsa012301.93417301
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.85599105
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.73934328
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.68233405
20Parkinsons disease_Homo sapiens_hsa050121.67664665
21Butanoate metabolism_Homo sapiens_hsa006501.61714158
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48835575
23Lysosome_Homo sapiens_hsa041421.43853488
24PPAR signaling pathway_Homo sapiens_hsa033201.43815922
25Chronic myeloid leukemia_Homo sapiens_hsa052201.35190489
26Arginine biosynthesis_Homo sapiens_hsa002201.34485578
27Lysine degradation_Homo sapiens_hsa003101.33132000
28Insulin resistance_Homo sapiens_hsa049311.32889621
29Non-small cell lung cancer_Homo sapiens_hsa052231.30704592
30Oxidative phosphorylation_Homo sapiens_hsa001901.30460674
31Glucagon signaling pathway_Homo sapiens_hsa049221.30179665
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26073881
33B cell receptor signaling pathway_Homo sapiens_hsa046621.24839042
34Fructose and mannose metabolism_Homo sapiens_hsa000511.22771744
35Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21790460
36Prion diseases_Homo sapiens_hsa050201.18231490
37Insulin signaling pathway_Homo sapiens_hsa049101.15415734
38Tryptophan metabolism_Homo sapiens_hsa003801.14647399
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13545896
40Starch and sucrose metabolism_Homo sapiens_hsa005001.12325717
41Alzheimers disease_Homo sapiens_hsa050101.11258238
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10535784
43Adipocytokine signaling pathway_Homo sapiens_hsa049201.09813063
44Osteoclast differentiation_Homo sapiens_hsa043801.08361004
45Viral myocarditis_Homo sapiens_hsa054161.07139403
46Galactose metabolism_Homo sapiens_hsa000521.06006579
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05977307
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03318498
49Fatty acid biosynthesis_Homo sapiens_hsa000611.02678132
50AMPK signaling pathway_Homo sapiens_hsa041520.99491056
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96617590
52Pancreatic cancer_Homo sapiens_hsa052120.96168295
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93568947
54Leishmaniasis_Homo sapiens_hsa051400.92619023
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.92294097
56beta-Alanine metabolism_Homo sapiens_hsa004100.91767706
57Toxoplasmosis_Homo sapiens_hsa051450.91585623
58Huntingtons disease_Homo sapiens_hsa050160.89195676
59Vibrio cholerae infection_Homo sapiens_hsa051100.87365373
60Arginine and proline metabolism_Homo sapiens_hsa003300.85652334
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84996249
62Hepatitis C_Homo sapiens_hsa051600.84423118
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82919448
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82694785
65Endocytosis_Homo sapiens_hsa041440.81948717
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80243917
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79930143
68Shigellosis_Homo sapiens_hsa051310.78598875
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.78220410
70Glioma_Homo sapiens_hsa052140.77140519
71Pertussis_Homo sapiens_hsa051330.75626765
72N-Glycan biosynthesis_Homo sapiens_hsa005100.75272779
73Nitrogen metabolism_Homo sapiens_hsa009100.75143940
74Salmonella infection_Homo sapiens_hsa051320.74718233
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74040864
76Fat digestion and absorption_Homo sapiens_hsa049750.73927021
77Peroxisome_Homo sapiens_hsa041460.73873632
78TNF signaling pathway_Homo sapiens_hsa046680.73785036
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73732338
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72406202
81Tuberculosis_Homo sapiens_hsa051520.72237230
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71597072
83Apoptosis_Homo sapiens_hsa042100.70504662
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70374553
85Pentose phosphate pathway_Homo sapiens_hsa000300.70292053
86HIF-1 signaling pathway_Homo sapiens_hsa040660.70079816
87Type II diabetes mellitus_Homo sapiens_hsa049300.68824534
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.67464052
89Influenza A_Homo sapiens_hsa051640.67156310
90Bile secretion_Homo sapiens_hsa049760.67137879
91mTOR signaling pathway_Homo sapiens_hsa041500.66337799
92Fatty acid elongation_Homo sapiens_hsa000620.65896271
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.65328117
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64441390
95Endometrial cancer_Homo sapiens_hsa052130.64411393
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63286511
97Hepatitis B_Homo sapiens_hsa051610.62874198
98HTLV-I infection_Homo sapiens_hsa051660.62626059
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62568311
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.62049492
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61399661
102Inositol phosphate metabolism_Homo sapiens_hsa005620.60873340
103Small cell lung cancer_Homo sapiens_hsa052220.60676378
104Choline metabolism in cancer_Homo sapiens_hsa052310.56882263
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56435401
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.55466060
107Glycerolipid metabolism_Homo sapiens_hsa005610.52915396
108Primary immunodeficiency_Homo sapiens_hsa053400.52711985
109Focal adhesion_Homo sapiens_hsa045100.52381512
110Thyroid cancer_Homo sapiens_hsa052160.51722767
111Gastric acid secretion_Homo sapiens_hsa049710.50856819
112Base excision repair_Homo sapiens_hsa034100.49784474
113Vitamin B6 metabolism_Homo sapiens_hsa007500.49304223
114Oxytocin signaling pathway_Homo sapiens_hsa049210.48920766
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.48247550
116Insulin secretion_Homo sapiens_hsa049110.48149040
117Selenocompound metabolism_Homo sapiens_hsa004500.44996234
118ErbB signaling pathway_Homo sapiens_hsa040120.44243440
119Circadian rhythm_Homo sapiens_hsa047100.43781327
120VEGF signaling pathway_Homo sapiens_hsa043700.43692024
121Calcium signaling pathway_Homo sapiens_hsa040200.42752993
122Prolactin signaling pathway_Homo sapiens_hsa049170.42578710
123Herpes simplex infection_Homo sapiens_hsa051680.42551498
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41776961
125Glutathione metabolism_Homo sapiens_hsa004800.41553873
126Phenylalanine metabolism_Homo sapiens_hsa003600.40508676
127Viral carcinogenesis_Homo sapiens_hsa052030.39306481
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38776142
129Staphylococcus aureus infection_Homo sapiens_hsa051500.38152066
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38128772
131Tight junction_Homo sapiens_hsa045300.36021748
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31750807
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31149735
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.31148631
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30320888
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29136742
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28831030
138Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27162475
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.27137179
140Notch signaling pathway_Homo sapiens_hsa043300.26200788
141Sulfur relay system_Homo sapiens_hsa041220.24833191
142Pancreatic secretion_Homo sapiens_hsa049720.23307801
143cAMP signaling pathway_Homo sapiens_hsa040240.20945741
144Proteoglycans in cancer_Homo sapiens_hsa052050.20719140
145Protein digestion and absorption_Homo sapiens_hsa049740.18937425
146Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.18027953
147Bladder cancer_Homo sapiens_hsa052190.17843494
148GnRH signaling pathway_Homo sapiens_hsa049120.17158201
149Adherens junction_Homo sapiens_hsa045200.17053860
150Metabolic pathways_Homo sapiens_hsa011000.16899245
151ABC transporters_Homo sapiens_hsa020100.16669514
152Amoebiasis_Homo sapiens_hsa051460.16558438
153Gap junction_Homo sapiens_hsa045400.15472511
154Acute myeloid leukemia_Homo sapiens_hsa052210.15163589
155Neurotrophin signaling pathway_Homo sapiens_hsa047220.14080566
156Renin secretion_Homo sapiens_hsa049240.13589679
157Estrogen signaling pathway_Homo sapiens_hsa049150.10860904

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