FASTKD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is localized in the mitochondrial inner compartment and that may play a role in mitochondrial apoptosis. Nonsense mutations have been reported to result in cytochrome c oxidase deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.71648286
2nucleobase biosynthetic process (GO:0046112)5.28432699
3purine nucleobase biosynthetic process (GO:0009113)5.14185989
4DNA replication initiation (GO:0006270)4.62334676
5DNA strand elongation involved in DNA replication (GO:0006271)4.61889391
6IMP biosynthetic process (GO:0006188)4.52560365
7CENP-A containing nucleosome assembly (GO:0034080)4.48426102
8telomere maintenance via semi-conservative replication (GO:0032201)4.47316369
9DNA strand elongation (GO:0022616)4.45902339
10chromatin remodeling at centromere (GO:0031055)4.43587218
11mitotic metaphase plate congression (GO:0007080)4.42962369
12proteasome assembly (GO:0043248)4.17841126
13ribosomal small subunit assembly (GO:0000028)4.16464064
14formation of translation preinitiation complex (GO:0001731)4.13971194
15telomere maintenance via recombination (GO:0000722)4.08532302
16maturation of SSU-rRNA (GO:0030490)4.07508098
17cullin deneddylation (GO:0010388)4.04487790
18DNA replication checkpoint (GO:0000076)4.04044836
19IMP metabolic process (GO:0046040)4.01617304
20protein localization to kinetochore (GO:0034501)4.00117287
21DNA catabolic process, exonucleolytic (GO:0000738)3.98531755
22DNA replication-dependent nucleosome assembly (GO:0006335)3.97361088
23DNA replication-dependent nucleosome organization (GO:0034723)3.97361088
24metaphase plate congression (GO:0051310)3.90525532
25DNA unwinding involved in DNA replication (GO:0006268)3.89000991
26mitotic recombination (GO:0006312)3.86441961
27non-recombinational repair (GO:0000726)3.86209300
28double-strand break repair via nonhomologous end joining (GO:0006303)3.86209300
29nuclear pore organization (GO:0006999)3.83457080
30protein deneddylation (GO:0000338)3.79908035
31DNA replication-independent nucleosome assembly (GO:0006336)3.78470081
32DNA replication-independent nucleosome organization (GO:0034724)3.78470081
33attachment of spindle microtubules to kinetochore (GO:0008608)3.76075316
34ribosome biogenesis (GO:0042254)3.75616656
35ribosomal large subunit biogenesis (GO:0042273)3.71010052
36ribosome assembly (GO:0042255)3.64694788
37histone exchange (GO:0043486)3.63614887
38DNA ligation (GO:0006266)3.62188506
39kinetochore organization (GO:0051383)3.60901470
40mitotic nuclear envelope disassembly (GO:0007077)3.60874322
41telomere maintenance via telomere lengthening (GO:0010833)3.60838535
42negative regulation of DNA-dependent DNA replication (GO:2000104)3.58183480
43folic acid-containing compound biosynthetic process (GO:0009396)3.57314055
44establishment of chromosome localization (GO:0051303)3.55497337
45pseudouridine synthesis (GO:0001522)3.55002542
46regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.51561496
47regulation of mitotic spindle checkpoint (GO:1903504)3.51561496
48mitotic sister chromatid segregation (GO:0000070)3.51393200
49mitotic chromosome condensation (GO:0007076)3.50573134
50mitochondrial RNA metabolic process (GO:0000959)3.50477017
51exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.50295011
52protein localization to chromosome, centromeric region (GO:0071459)3.48262047
53ribonucleoprotein complex biogenesis (GO:0022613)3.47992903
54nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46981766
55negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.46974096
56maturation of 5.8S rRNA (GO:0000460)3.44348142
57spliceosomal snRNP assembly (GO:0000387)3.44282061
58amino acid activation (GO:0043038)3.42519657
59tRNA aminoacylation (GO:0043039)3.42519657
60rRNA processing (GO:0006364)3.41327732
61viral mRNA export from host cell nucleus (GO:0046784)3.41260146
62rRNA modification (GO:0000154)3.40927094
63nucleotide-excision repair, DNA gap filling (GO:0006297)3.40253946
64tRNA aminoacylation for protein translation (GO:0006418)3.40202793
65regulation of cellular amino acid metabolic process (GO:0006521)3.39855249
66somatic diversification of immune receptors via somatic mutation (GO:0002566)3.39826424
67somatic hypermutation of immunoglobulin genes (GO:0016446)3.39826424
68regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.36822749
69response to X-ray (GO:0010165)3.36431459
70anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.36306604
71regulation of helicase activity (GO:0051095)3.34453370
72DNA deamination (GO:0045006)3.33961658
73establishment of integrated proviral latency (GO:0075713)3.33617535
74membrane disassembly (GO:0030397)3.30351796
75nuclear envelope disassembly (GO:0051081)3.30351796
76positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.29773552
77rRNA metabolic process (GO:0016072)3.29621848
78positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.28824546
79transcription from mitochondrial promoter (GO:0006390)3.28604625
80transcription-coupled nucleotide-excision repair (GO:0006283)3.26328861
81establishment of viral latency (GO:0019043)3.22000141
82cell cycle G1/S phase transition (GO:0044843)3.20318878
83G1/S transition of mitotic cell cycle (GO:0000082)3.20318878
84nuclear pore complex assembly (GO:0051292)3.19969563
85sister chromatid segregation (GO:0000819)3.19751208
86positive regulation of ligase activity (GO:0051351)3.18001909
87pteridine-containing compound biosynthetic process (GO:0042559)3.17800260
88signal peptide processing (GO:0006465)3.17786114
89somatic recombination of immunoglobulin gene segments (GO:0016447)3.17506025
90respiratory chain complex IV assembly (GO:0008535)3.17398528
91L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.15887614
92replication fork processing (GO:0031297)3.15241184
93RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.12215898
94chaperone-mediated protein transport (GO:0072321)3.12139929
95negative regulation of ligase activity (GO:0051352)3.12085751
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.12085751
97lactate metabolic process (GO:0006089)3.11425139
98kinetochore assembly (GO:0051382)3.11391416
99histone mRNA metabolic process (GO:0008334)3.11016033
100mitotic spindle checkpoint (GO:0071174)3.09555068
101mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.09212211
102rRNA methylation (GO:0031167)3.07945887
103regulation of mitochondrial translation (GO:0070129)3.07697237
104regulation of ubiquitin-protein transferase activity (GO:0051438)3.05375958
105negative regulation of DNA recombination (GO:0045910)3.05082033
106signal transduction involved in DNA integrity checkpoint (GO:0072401)3.04372666
107signal transduction involved in DNA damage checkpoint (GO:0072422)3.04372666
108negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.04191077
109regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.02446083
110cellular component biogenesis (GO:0044085)3.01005445
111negative regulation of sister chromatid segregation (GO:0033046)3.00850125
112negative regulation of mitotic sister chromatid separation (GO:2000816)3.00850125
113negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00850125
114negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00850125
115signal transduction involved in cell cycle checkpoint (GO:0072395)3.00146854
116telomere organization (GO:0032200)2.99040988
117regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.99024987
118regulation of mitotic metaphase/anaphase transition (GO:0030071)2.99024987
119branched-chain amino acid catabolic process (GO:0009083)2.98827458
120telomere maintenance via telomerase (GO:0007004)2.98595305
121oxidative phosphorylation (GO:0006119)2.98489603
122spindle checkpoint (GO:0031577)2.98090926
123telomere maintenance (GO:0000723)2.97898847
1247-methylguanosine mRNA capping (GO:0006370)2.97800953
125negative regulation of chromosome segregation (GO:0051985)2.97662844
126protein K6-linked ubiquitination (GO:0085020)2.97621954
127regulation of ligase activity (GO:0051340)2.96504635
128DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.96478254
129organelle disassembly (GO:1903008)2.96337608
130somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.95666342
131somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.95666342
132isotype switching (GO:0045190)2.95666342
133tRNA metabolic process (GO:0006399)2.95351987
134transcription elongation from RNA polymerase I promoter (GO:0006362)2.95088420
135signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.94951715
136intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.94951715
137mismatch repair (GO:0006298)2.94463773
138spindle assembly checkpoint (GO:0071173)2.94211721
139somatic diversification of immunoglobulins (GO:0016445)2.93804903
140pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.93103378
141regulation of translational termination (GO:0006449)2.92508789
1427-methylguanosine RNA capping (GO:0009452)2.92280533
143RNA capping (GO:0036260)2.92280533
144signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.92085393
145signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.92085393
146signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.92085393
147postreplication repair (GO:0006301)2.91088182

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.31427468
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.52480206
3* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.16478954
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.80000185
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58414571
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.53226188
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.38746374
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.28691986
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.28082172
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.08622132
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08138927
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.04244570
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.03785013
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.98097762
15* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.92445736
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.83519239
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.68092628
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59723226
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.58362886
20* VDR_23849224_ChIP-Seq_CD4+_Human2.46905416
21AR_21909140_ChIP-Seq_LNCAP_Human2.42334866
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28688419
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.27890465
24* FLI1_27457419_Chip-Seq_LIVER_Mouse2.27542048
25* XRN2_22483619_ChIP-Seq_HELA_Human2.27172328
26* DCP1A_22483619_ChIP-Seq_HELA_Human2.18595959
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18020586
28* FOXP3_21729870_ChIP-Seq_TREG_Human2.13777606
29THAP11_20581084_ChIP-Seq_MESCs_Mouse2.12604962
30RBPJ_22232070_ChIP-Seq_NCS_Mouse2.12217311
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10058848
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08918363
33ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08088096
34ELK1_19687146_ChIP-ChIP_HELA_Human1.97430651
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.96691555
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96263015
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.94896059
38* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93146353
39ZNF274_21170338_ChIP-Seq_K562_Hela1.92481663
40* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.92067585
41* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91752308
42TTF2_22483619_ChIP-Seq_HELA_Human1.90360642
43GABP_19822575_ChIP-Seq_HepG2_Human1.88087881
44* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86771337
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.86688659
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84418084
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84040860
48* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82195613
49* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79779465
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69036092
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68321732
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.68118423
53EWS_26573619_Chip-Seq_HEK293_Human1.66771126
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64988431
55FUS_26573619_Chip-Seq_HEK293_Human1.64938526
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63272432
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59349836
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59243295
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54233299
60IGF1R_20145208_ChIP-Seq_DFB_Human1.47616785
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46948041
62KDM5A_27292631_Chip-Seq_BREAST_Human1.42616339
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38207008
64VDR_22108803_ChIP-Seq_LS180_Human1.37009526
65CIITA_25753668_ChIP-Seq_RAJI_Human1.33044759
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30918576
67* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28101875
68TAF15_26573619_Chip-Seq_HEK293_Human1.26436603
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24898228
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20136814
71* EZH2_27294783_Chip-Seq_NPCs_Mouse1.18989416
72* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18911050
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17881727
74* NFE2_27457419_Chip-Seq_LIVER_Mouse1.17872745
75* MYC_18940864_ChIP-ChIP_HL60_Human1.16918450
76* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16535163
77* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15954428
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15271540
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.13954695
80TFEB_21752829_ChIP-Seq_HELA_Human1.13077366
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11504745
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09530371
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08684962
84* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08623302
85* P300_19829295_ChIP-Seq_ESCs_Human1.08511264
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07816929
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05795937
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04239389
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01070248
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00830997
91* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00590348
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00450213
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99894063
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98620453
95SOX2_16153702_ChIP-ChIP_HESCs_Human0.98471016
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97459350
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96199264
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95532754
99* CRX_20693478_ChIP-Seq_RETINA_Mouse0.93339550
100SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92306594
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90784678
102* SOX17_20123909_ChIP-Seq_XEN_Mouse0.89793265
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88200086
104EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87631635
105SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86453586
106* P300_18555785_Chip-Seq_ESCs_Mouse0.86128695
107SALL1_21062744_ChIP-ChIP_HESCs_Human0.86032464
108* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84261976
109NOTCH1_21737748_ChIP-Seq_TLL_Human0.83831533
110ELK1_22589737_ChIP-Seq_MCF10A_Human0.83686171
111ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82549898
112* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.82311936
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80831382
114GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80247956
115SALL4_22934838_ChIP-ChIP_CD34+_Human0.79608301
116* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.79114929
117* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78814515
118HTT_18923047_ChIP-ChIP_STHdh_Human0.78776052
119EGR1_19374776_ChIP-ChIP_THP-1_Human0.78673702
120IRF1_19129219_ChIP-ChIP_H3396_Human0.78488782
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78187511
122CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75583095
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.75457199
124FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.75292718
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.72812083
126* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72419497
127NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.72125989
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.71155914
129SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.69639092
130* NANOG_21062744_ChIP-ChIP_HESCs_Human0.69255209
131* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.68586060

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.47559026
2MP0010094_abnormal_chromosome_stability5.26465737
3MP0004957_abnormal_blastocyst_morpholog4.63468558
4MP0003111_abnormal_nucleus_morphology4.36620168
5MP0003806_abnormal_nucleotide_metabolis4.13352393
6MP0008058_abnormal_DNA_repair3.99121899
7MP0003077_abnormal_cell_cycle3.95387456
8MP0008057_abnormal_DNA_replication3.91821336
9MP0009697_abnormal_copulation3.21873781
10MP0003123_paternal_imprinting3.14938542
11MP0003941_abnormal_skin_development3.04139158
12MP0008007_abnormal_cellular_replicative3.02958690
13MP0008932_abnormal_embryonic_tissue2.82881453
14MP0008877_abnormal_DNA_methylation2.81243284
15MP0003718_maternal_effect2.73868012
16MP0003195_calcinosis2.38685839
17MP0001730_embryonic_growth_arrest2.31143657
18MP0003786_premature_aging2.15393288
19MP0002396_abnormal_hematopoietic_system2.10357519
20MP0006072_abnormal_retinal_apoptosis2.05960540
21MP0000350_abnormal_cell_proliferation1.97568151
22MP0006054_spinal_hemorrhage1.89450041
23MP0006036_abnormal_mitochondrial_physio1.88783041
24MP0000372_irregular_coat_pigmentation1.87602749
25MP0003186_abnormal_redox_activity1.70090814
26MP0002254_reproductive_system_inflammat1.68969488
27MP0001697_abnormal_embryo_size1.67031629
28MP0010307_abnormal_tumor_latency1.65435931
29MP0001672_abnormal_embryogenesis/_devel1.62419342
30MP0005380_embryogenesis_phenotype1.62419342
31MP0003121_genomic_imprinting1.56768208
32MP0003984_embryonic_growth_retardation1.50281295
33MP0009379_abnormal_foot_pigmentation1.50075058
34MP0008875_abnormal_xenobiotic_pharmacok1.47859999
35MP0002088_abnormal_embryonic_growth/wei1.45171307
36MP0005253_abnormal_eye_physiology1.44311003
37MP0002080_prenatal_lethality1.41835956
38MP0003315_abnormal_perineum_morphology1.40947791
39MP0001661_extended_life_span1.40065361
40MP0006035_abnormal_mitochondrial_morpho1.37397720
41MP0002160_abnormal_reproductive_system1.35014568
42MP0001529_abnormal_vocalization1.33876243
43MP0002837_dystrophic_cardiac_calcinosis1.31498760
44MP0002090_abnormal_vision1.29427260
45MP0000313_abnormal_cell_death1.25090512
46MP0003567_abnormal_fetal_cardiomyocyte1.24170264
47MP0010352_gastrointestinal_tract_polyps1.23990482
48MP0005266_abnormal_metabolism1.22680151
49MP0003646_muscle_fatigue1.19738284
50MP0000647_abnormal_sebaceous_gland1.19165566
51MP0002085_abnormal_embryonic_tissue1.16624887
52MP0004084_abnormal_cardiac_muscle1.15907701
53MP0002210_abnormal_sex_determination1.14660445
54MP0001984_abnormal_olfaction1.13498984
55MP0003890_abnormal_embryonic-extraembry1.12801736
56MP0002084_abnormal_developmental_patter1.10820971
57MP0005408_hypopigmentation1.10159635
58MP0002086_abnormal_extraembryonic_tissu1.08603985
59MP0002019_abnormal_tumor_incidence1.08548084
60MP0002132_abnormal_respiratory_system1.07397858
61MP0001293_anophthalmia1.06062651
62MP0004133_heterotaxia1.05632694
63MP0000358_abnormal_cell_content/1.05017207
64MP0000490_abnormal_crypts_of1.04648635
65MP0006292_abnormal_olfactory_placode1.04433480
66MP0003937_abnormal_limbs/digits/tail_de1.04318232
67MP0001145_abnormal_male_reproductive1.01904120
68MP0004197_abnormal_fetal_growth/weight/1.01795751
69MP0009672_abnormal_birth_weight0.99795336
70MP0008789_abnormal_olfactory_epithelium0.98304322
71MP0001929_abnormal_gametogenesis0.97747362
72MP0004808_abnormal_hematopoietic_stem0.95513856
73MP0001764_abnormal_homeostasis0.93508566
74MP0005389_reproductive_system_phenotype0.93177025
75MP0004147_increased_porphyrin_level0.92977735
76MP0010030_abnormal_orbit_morphology0.91087134
77MP0005187_abnormal_penis_morphology0.89653207
78MP0003221_abnormal_cardiomyocyte_apopto0.88224641
79MP0000653_abnormal_sex_gland0.87779868
80MP0005394_taste/olfaction_phenotype0.86747398
81MP0005499_abnormal_olfactory_system0.86747398
82MP0001324_abnormal_eye_pigmentation0.86021097
83MP0002269_muscular_atrophy0.83860947
84MP0002751_abnormal_autonomic_nervous0.83237350
85MP0003119_abnormal_digestive_system0.82951124
86MP0008873_increased_physiological_sensi0.81780473
87MP0004215_abnormal_myocardial_fiber0.81346942
88MP0001119_abnormal_female_reproductive0.79310582
89MP0008995_early_reproductive_senescence0.77487751
90MP0002006_tumorigenesis0.76490375
91MP0003787_abnormal_imprinting0.75485793
92MP0002233_abnormal_nose_morphology0.73461937
93MP0009703_decreased_birth_body0.72534800
94MP0003950_abnormal_plasma_membrane0.72484075
95MP0005332_abnormal_amino_acid0.71963143
96MP0001177_atelectasis0.71913967
97MP0001191_abnormal_skin_condition0.71541105
98MP0002139_abnormal_hepatobiliary_system0.71367164
99MP0005395_other_phenotype0.71180509
100MP0005384_cellular_phenotype0.71047943
101MP0005397_hematopoietic_system_phenotyp0.68090223
102MP0001545_abnormal_hematopoietic_system0.68090223
103MP0002095_abnormal_skin_pigmentation0.67163464
104MP0003943_abnormal_hepatobiliary_system0.66889717
105MP0004233_abnormal_muscle_weight0.66464367
106MP0002111_abnormal_tail_morphology0.66284317
107MP0005391_vision/eye_phenotype0.66225307
108MP0000427_abnormal_hair_cycle0.64871450
109MP0005551_abnormal_eye_electrophysiolog0.64630392
110MP0005084_abnormal_gallbladder_morpholo0.64486755
111MP0003763_abnormal_thymus_physiology0.64006250
112MP0002938_white_spotting0.63545470
113MP0005075_abnormal_melanosome_morpholog0.63120363
114MP0005360_urolithiasis0.62459667
115MP0000749_muscle_degeneration0.61807299
116MP0004134_abnormal_chest_morphology0.61205108
117MP0005085_abnormal_gallbladder_physiolo0.59458913
118MP0000049_abnormal_middle_ear0.58487728
119MP0000703_abnormal_thymus_morphology0.57385879
120MP0002127_abnormal_cardiovascular_syste0.55390517
121MP0003698_abnormal_male_reproductive0.55170155
122MP0001919_abnormal_reproductive_system0.55000825
123MP0003656_abnormal_erythrocyte_physiolo0.54975612
124MP0001853_heart_inflammation0.54109085
125MP0005376_homeostasis/metabolism_phenot0.53816239
126MP0000678_abnormal_parathyroid_gland0.53319401
127MP0004782_abnormal_surfactant_physiolog0.51296477
128MP0005621_abnormal_cell_physiology0.50855691
129MP0000689_abnormal_spleen_morphology0.50772092
130MP0009053_abnormal_anal_canal0.50608307
131MP0002161_abnormal_fertility/fecundity0.49098176
132MP0002102_abnormal_ear_morphology0.48606150
133MP0002722_abnormal_immune_system0.47488014

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.29977558
2Increased serum pyruvate (HP:0003542)3.93403352
3Abnormality of glycolysis (HP:0004366)3.93403352
4Chromsome breakage (HP:0040012)3.68216710
5Methylmalonic acidemia (HP:0002912)3.67729431
6Breast hypoplasia (HP:0003187)3.66358700
7Carpal bone hypoplasia (HP:0001498)3.64409972
8Oral leukoplakia (HP:0002745)3.59113766
9Aplastic anemia (HP:0001915)3.48145295
10Reticulocytopenia (HP:0001896)3.40111088
11Colon cancer (HP:0003003)3.35885448
12Hepatocellular necrosis (HP:0001404)3.28349262
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.17766022
14Abnormality of methionine metabolism (HP:0010901)3.15870558
15Abnormal number of erythroid precursors (HP:0012131)3.14936608
16Acute necrotizing encephalopathy (HP:0006965)3.14179815
17Hepatic necrosis (HP:0002605)3.13735382
18Abnormal mitochondria in muscle tissue (HP:0008316)3.12193650
19Abnormality of cells of the erythroid lineage (HP:0012130)3.11438214
20* Increased CSF lactate (HP:0002490)3.10346005
21Abnormality of the preputium (HP:0100587)3.02094671
22Rough bone trabeculation (HP:0100670)3.01028996
23Abnormality of chromosome stability (HP:0003220)2.99860880
24* Mitochondrial inheritance (HP:0001427)2.99693480
25* Increased serum lactate (HP:0002151)2.97300246
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.91982804
27Abnormality of alanine metabolism (HP:0010916)2.91982804
28Hyperalaninemia (HP:0003348)2.91982804
29Medulloblastoma (HP:0002885)2.91622607
30Pancreatic islet-cell hyperplasia (HP:0004510)2.91238312
31Degeneration of anterior horn cells (HP:0002398)2.88349018
32Abnormality of the anterior horn cell (HP:0006802)2.88349018
33Methylmalonic aciduria (HP:0012120)2.82274594
34Agnosia (HP:0010524)2.82196616
35Abnormality of the labia minora (HP:0012880)2.81473018
36Microvesicular hepatic steatosis (HP:0001414)2.76490843
37Hypoglycemic coma (HP:0001325)2.75930400
38Acute encephalopathy (HP:0006846)2.75697672
39Hyperglycinemia (HP:0002154)2.70824391
40Absent radius (HP:0003974)2.70414905
41Meckel diverticulum (HP:0002245)2.65679603
42Abnormality of aspartate family amino acid metabolism (HP:0010899)2.64402551
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.62756257
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.62756257
45Stenosis of the external auditory canal (HP:0000402)2.53970933
46Progressive macrocephaly (HP:0004481)2.52627087
47Patellar aplasia (HP:0006443)2.52306571
48Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.50651783
49Abnormality of the ileum (HP:0001549)2.49977381
50Selective tooth agenesis (HP:0001592)2.48238356
51Aplasia involving forearm bones (HP:0009822)2.47841074
52Absent forearm bone (HP:0003953)2.47841074
53Cerebral hypomyelination (HP:0006808)2.45716309
54Neoplasm of the adrenal gland (HP:0100631)2.44936564
55Abnormality of pyrimidine metabolism (HP:0004353)2.44907864
5611 pairs of ribs (HP:0000878)2.44686967
57Cerebral edema (HP:0002181)2.44598244
58Abnormal lung lobation (HP:0002101)2.44440887
59Absent thumb (HP:0009777)2.43932787
60Abnormality of serum amino acid levels (HP:0003112)2.43351380
61Aplasia/Hypoplasia of the patella (HP:0006498)2.39464240
62Exercise-induced muscle cramps (HP:0003710)2.35833282
63Median cleft lip (HP:0000161)2.35264597
64Small intestinal stenosis (HP:0012848)2.32784977
65Duodenal stenosis (HP:0100867)2.32784977
66Ependymoma (HP:0002888)2.32184459
67* Lactic acidosis (HP:0003128)2.31787762
68Rhabdomyosarcoma (HP:0002859)2.30732700
69Abnormal protein glycosylation (HP:0012346)2.27472519
70Abnormal glycosylation (HP:0012345)2.27472519
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27472519
72Abnormal protein N-linked glycosylation (HP:0012347)2.27472519
73* Increased hepatocellular lipid droplets (HP:0006565)2.27252550
74Impulsivity (HP:0100710)2.27016522
75Abnormality of endocrine pancreas physiology (HP:0012093)2.25808249
76Abnormality of the pancreatic islet cells (HP:0006476)2.25808249
77Irregular epiphyses (HP:0010582)2.24853470
78Abnormality of serine family amino acid metabolism (HP:0010894)2.24269082
79Abnormality of glycine metabolism (HP:0010895)2.24269082
80Macrocytic anemia (HP:0001972)2.23153258
81Myelodysplasia (HP:0002863)2.22000439
82Aplasia/Hypoplasia of the uvula (HP:0010293)2.20226805
83Hyperglycinuria (HP:0003108)2.20103289
84* Exercise intolerance (HP:0003546)2.19348759
85Neoplasm of the colon (HP:0100273)2.16586716
86Premature graying of hair (HP:0002216)2.15764289
87Abnormal trabecular bone morphology (HP:0100671)2.15425305
88Neoplasm of the pancreas (HP:0002894)2.15041378
89Type I transferrin isoform profile (HP:0003642)2.12309405
90Volvulus (HP:0002580)2.11544200
91Abnormality of the vitamin B12 metabolism (HP:0004341)2.10907397
92Hypoglycemic seizures (HP:0002173)2.10634863
93Aplasia/Hypoplasia of the sacrum (HP:0008517)2.10011713
94Reduced antithrombin III activity (HP:0001976)2.09762053
95Renal cortical cysts (HP:0000803)2.08765217
96Horseshoe kidney (HP:0000085)2.08704379
97Prominent metopic ridge (HP:0005487)2.08625878
98Lethargy (HP:0001254)2.08303319
99Palpitations (HP:0001962)2.07847992
100Sloping forehead (HP:0000340)2.07777561
101Progressive inability to walk (HP:0002505)2.07648895
102Hyperinsulinemic hypoglycemia (HP:0000825)2.07530467
103Bone marrow hypocellularity (HP:0005528)2.06785641
104Megaloblastic anemia (HP:0001889)2.06439703
105Abnormality of vitamin B metabolism (HP:0004340)2.04975483
106Spastic diplegia (HP:0001264)2.04403275
107CNS demyelination (HP:0007305)2.04378838
108Pancytopenia (HP:0001876)2.03701825
109Multiple enchondromatosis (HP:0005701)2.02657433
110Generalized aminoaciduria (HP:0002909)2.02064527
111Biliary tract neoplasm (HP:0100574)2.00946570
112Pancreatic cysts (HP:0001737)2.00912862
113Respiratory failure (HP:0002878)2.00604235
114* Lipid accumulation in hepatocytes (HP:0006561)1.99501493
115Abnormal spermatogenesis (HP:0008669)1.97679964
116Abnormal biliary tract morphology (HP:0012440)1.97330261
117Neoplasm of the rectum (HP:0100743)1.96429001
118Cellular immunodeficiency (HP:0005374)1.96102299
119Nephroblastoma (Wilms tumor) (HP:0002667)1.96008027
120Triphalangeal thumb (HP:0001199)1.95818299
121Ovarian neoplasm (HP:0100615)1.95650055
122Abnormal biliary tract physiology (HP:0012439)1.95576228
123Bile duct proliferation (HP:0001408)1.95576228
124* Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95546588
125Abnormality of the duodenum (HP:0002246)1.94874337
126Supernumerary spleens (HP:0009799)1.94845849
127Embryonal renal neoplasm (HP:0011794)1.94336318
128Secondary amenorrhea (HP:0000869)1.92395612
129CNS hypomyelination (HP:0003429)1.91729035
130Pancreatic fibrosis (HP:0100732)1.89106249
131Hypothermia (HP:0002045)1.88963300
132Gonadotropin excess (HP:0000837)1.88637513
133Spinal muscular atrophy (HP:0007269)1.86906534
134Leukodystrophy (HP:0002415)1.86792101
135Sparse eyelashes (HP:0000653)1.83989711
136Clubbing of toes (HP:0100760)1.83726466
137Emotional lability (HP:0000712)1.83450909
138Abnormality of the metopic suture (HP:0005556)1.82580944
139Glioma (HP:0009733)1.80674558
140* Respiratory difficulties (HP:0002880)1.79900560
141Abnormality of the renal collecting system (HP:0004742)1.78638375
142Bifid tongue (HP:0010297)1.78516738
143Ragged-red muscle fibers (HP:0003200)1.78233590
144* Increased intramyocellular lipid droplets (HP:0012240)1.77941083
145Female pseudohermaphroditism (HP:0010458)1.77282841
146Hypobetalipoproteinemia (HP:0003563)1.76819317
147Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76224196
148Dicarboxylic aciduria (HP:0003215)1.76224196

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.79934471
2WEE14.44057126
3EIF2AK14.11917228
4CDC73.65558084
5SRPK13.28939148
6NEK13.03419322
7TSSK62.99892735
8EIF2AK32.80143944
9TRIM282.78221072
10BRSK22.70184863
11STK162.55282561
12PBK2.38637543
13TTK2.30198276
14MAP4K22.18638280
15MKNK12.16294689
16CCNB12.04847895
17VRK12.04281293
18ACVR1B2.03749808
19VRK21.87269334
20NEK21.85838865
21MKNK21.83831934
22PLK41.81650327
23PLK11.77701429
24PLK31.67701763
25ERBB31.67600630
26TLK11.57914099
27TNIK1.56059881
28FRK1.54928313
29ZAK1.52175951
30AURKB1.48980699
31NME21.48134440
32BMPR1B1.47953685
33BRSK11.47739251
34ATR1.47040633
35NME11.41592819
36BCKDK1.36232940
37STK38L1.34279017
38RPS6KB21.33715533
39TAOK21.24479392
40TAF11.23137642
41CDK71.21608475
42CHEK21.20313323
43AURKA1.16330896
44PASK1.13154869
45MAP3K111.06897388
46STK391.04480352
47CDK80.99061487
48CSNK1G10.96499861
49MAP3K80.94824308
50MAP2K30.89891927
51MAP3K120.88895838
52MAP3K30.88848437
53PDK40.88474308
54PDK30.88474308
55BRAF0.86812756
56OXSR10.86507422
57CSNK1G30.84361657
58STK40.83529455
59TESK10.83318951
60CHEK10.82966239
61OBSCN0.80796050
62STK240.79986164
63CDK40.79950395
64FLT30.79510132
65AKT30.78474711
66ATM0.78010172
67EIF2AK20.77403786
68CSNK2A20.74550219
69RPS6KA40.74302654
70CSNK1G20.74233405
71TIE10.73538804
72SCYL20.70339922
73TESK20.69169127
74EPHA20.67666971
75CSNK2A10.67342065
76MST40.65445605
77MAP3K40.61608452
78NUAK10.60841067
79STK100.60406879
80CDK20.60275726
81CSNK1A1L0.59884963
82DYRK30.59539313
83GRK10.57939325
84LATS10.57133987
85TGFBR10.56440657
86CDK10.54920575
87ADRBK20.53333004
88LIMK10.53046549
89MELK0.51576376
90PLK20.47932330
91PAK40.45256164
92MAP2K60.44225410
93BCR0.43548649
94BRD40.43193403
95YES10.42237272
96PHKG10.38702359
97PHKG20.38702359
98MAP3K50.38575803
99WNK40.38043855
100PAK10.37763214
101CDK190.36687792
102RPS6KA50.35613794
103ALK0.34963657
104PRKCE0.34610732
105STK30.33968748
106CDK120.32265814
107PDK20.30575807
108TXK0.29771715
109DAPK10.28300297
110PRKDC0.27826216
111PRKCI0.27131790
112CSNK1E0.26795995
113PINK10.26340667
114CLK10.25985849
115PIM10.24902105
116TEC0.24607049
117NEK90.23914641
118WNK30.23487421
119PAK30.22989987
120PRKG20.22218831
121ERBB40.22207056
122RPS6KB10.21511063
123AKT20.18476303
124CDK60.18442906
125MYLK0.17977079
126RAF10.16778947
127SIK30.15502203
128PIM20.14394704
129FGFR10.14112013

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.53533968
2Mismatch repair_Homo sapiens_hsa034304.35290540
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.74072843
4Proteasome_Homo sapiens_hsa030503.66841082
5RNA polymerase_Homo sapiens_hsa030203.13407824
6Ribosome_Homo sapiens_hsa030103.05154910
7Spliceosome_Homo sapiens_hsa030402.91606935
8RNA transport_Homo sapiens_hsa030132.91155427
9One carbon pool by folate_Homo sapiens_hsa006702.76367910
10Nucleotide excision repair_Homo sapiens_hsa034202.67527768
11Homologous recombination_Homo sapiens_hsa034402.65606416
12Base excision repair_Homo sapiens_hsa034102.52179070
13Pyrimidine metabolism_Homo sapiens_hsa002402.50532141
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.42253447
15Cell cycle_Homo sapiens_hsa041102.30683364
16Non-homologous end-joining_Homo sapiens_hsa034502.11591101
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.92848946
18RNA degradation_Homo sapiens_hsa030181.92632787
19Basal transcription factors_Homo sapiens_hsa030221.92296918
20Fanconi anemia pathway_Homo sapiens_hsa034601.86484580
21Parkinsons disease_Homo sapiens_hsa050121.55748583
22Oxidative phosphorylation_Homo sapiens_hsa001901.49767754
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.48040271
24Purine metabolism_Homo sapiens_hsa002301.45304540
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.45208650
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40184487
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39931952
28Biosynthesis of amino acids_Homo sapiens_hsa012301.38331418
29Protein export_Homo sapiens_hsa030601.38152009
30mRNA surveillance pathway_Homo sapiens_hsa030151.36047390
31Carbon metabolism_Homo sapiens_hsa012001.34295473
32Huntingtons disease_Homo sapiens_hsa050161.31378994
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12617532
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10488344
35Folate biosynthesis_Homo sapiens_hsa007901.08063840
36Systemic lupus erythematosus_Homo sapiens_hsa053221.06304170
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03065074
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.03021862
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02741137
40Selenocompound metabolism_Homo sapiens_hsa004501.01853398
41Pyruvate metabolism_Homo sapiens_hsa006200.97379235
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97256102
43Pentose phosphate pathway_Homo sapiens_hsa000300.94762577
44Epstein-Barr virus infection_Homo sapiens_hsa051690.92653564
45p53 signaling pathway_Homo sapiens_hsa041150.91725420
46Fatty acid metabolism_Homo sapiens_hsa012120.85928808
47Glutathione metabolism_Homo sapiens_hsa004800.85040455
48Fructose and mannose metabolism_Homo sapiens_hsa000510.84055181
49Vitamin B6 metabolism_Homo sapiens_hsa007500.83591285
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81100473
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73468609
52Alzheimers disease_Homo sapiens_hsa050100.73325606
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72144601
54Oocyte meiosis_Homo sapiens_hsa041140.71792716
55Propanoate metabolism_Homo sapiens_hsa006400.71139949
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68724435
57Galactose metabolism_Homo sapiens_hsa000520.66417979
58beta-Alanine metabolism_Homo sapiens_hsa004100.64748690
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62206548
60Metabolic pathways_Homo sapiens_hsa011000.60709016
61Tryptophan metabolism_Homo sapiens_hsa003800.56503972
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56220218
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55062022
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52907038
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52237086
66Viral carcinogenesis_Homo sapiens_hsa052030.47237868
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47034977
68Antigen processing and presentation_Homo sapiens_hsa046120.46064385
69Peroxisome_Homo sapiens_hsa041460.43105847
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42113084
71Herpes simplex infection_Homo sapiens_hsa051680.40751889
72Sulfur relay system_Homo sapiens_hsa041220.40229614
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40136832
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37840041
75Legionellosis_Homo sapiens_hsa051340.37749945
76Regulation of autophagy_Homo sapiens_hsa041400.36152278
77Arginine and proline metabolism_Homo sapiens_hsa003300.35772806
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34045907
79Phototransduction_Homo sapiens_hsa047440.33240007
80Vitamin digestion and absorption_Homo sapiens_hsa049770.32988011
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31260422
82Fatty acid degradation_Homo sapiens_hsa000710.31133380
83Sulfur metabolism_Homo sapiens_hsa009200.30989212
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30698939
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30661910
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.30607530
87Ether lipid metabolism_Homo sapiens_hsa005650.29350088
88Cardiac muscle contraction_Homo sapiens_hsa042600.27603313
89Fatty acid elongation_Homo sapiens_hsa000620.27190989
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.26108606
91N-Glycan biosynthesis_Homo sapiens_hsa005100.24428166
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24089563
93Alcoholism_Homo sapiens_hsa050340.24045320
94Nitrogen metabolism_Homo sapiens_hsa009100.23567628
95Starch and sucrose metabolism_Homo sapiens_hsa005000.22390102
96Lysine degradation_Homo sapiens_hsa003100.21828801
97Tyrosine metabolism_Homo sapiens_hsa003500.21278759
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20683326
99HTLV-I infection_Homo sapiens_hsa051660.19726142
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.18505711
101Circadian rhythm_Homo sapiens_hsa047100.18404321
102Thyroid cancer_Homo sapiens_hsa052160.17952847
103Butanoate metabolism_Homo sapiens_hsa006500.17781773
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15597391
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15303339
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.15287903
107Chemical carcinogenesis_Homo sapiens_hsa052040.14302421
108Phenylalanine metabolism_Homo sapiens_hsa003600.10373939
109Caffeine metabolism_Homo sapiens_hsa002320.10005415
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.08963033
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.08785616
112Retinol metabolism_Homo sapiens_hsa008300.07617291
113TGF-beta signaling pathway_Homo sapiens_hsa043500.06827177
114Renin-angiotensin system_Homo sapiens_hsa046140.06275808
115Steroid biosynthesis_Homo sapiens_hsa001000.05577628
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.05324186

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