FASTKD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a small family of Fas-activated serine/threonine kinase domain (FASTKD) containing proteins that share an amino terminal mitochondrial targeting domain and multiple carboxy terminal FAST domains as well as a putative RNA-binding RAP domain. The members of this family are ubiquitously expressed and are generally most abundant in mitochondria-enriched tissues such as heart, skeletal muscle and brown-adipose tissue. Some members of this protein family may play a role in apoptosis. The protein encoded by this gene interacts with components of the mitochondrial respiratory and translation networks. A pseudogene of this gene is also present on chromosome 5. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.28191885
2nucleobase biosynthetic process (GO:0046112)5.15252569
3DNA strand elongation (GO:0022616)5.09510429
4DNA replication initiation (GO:0006270)5.04384128
5DNA replication checkpoint (GO:0000076)4.84955619
6purine nucleobase biosynthetic process (GO:0009113)4.74952951
7telomere maintenance via semi-conservative replication (GO:0032201)4.72069048
8DNA unwinding involved in DNA replication (GO:0006268)4.64070888
9mitotic metaphase plate congression (GO:0007080)4.44344142
10IMP biosynthetic process (GO:0006188)4.35806270
11telomere maintenance via recombination (GO:0000722)4.25670505
12DNA deamination (GO:0045006)4.10195232
13formation of translation preinitiation complex (GO:0001731)4.04179738
14DNA double-strand break processing (GO:0000729)4.02391754
15IMP metabolic process (GO:0046040)3.97978049
16mitotic recombination (GO:0006312)3.92965238
17folic acid-containing compound biosynthetic process (GO:0009396)3.91935889
18regulation of mitochondrial translation (GO:0070129)3.87858548
19protein localization to kinetochore (GO:0034501)3.86175222
20regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.81163816
21telomere maintenance via telomere lengthening (GO:0010833)3.79137031
22ribosome assembly (GO:0042255)3.78482202
23metaphase plate congression (GO:0051310)3.76736416
24ribosome biogenesis (GO:0042254)3.75692532
25chromatin remodeling at centromere (GO:0031055)3.70743629
26respiratory chain complex IV assembly (GO:0008535)3.70085433
27mitotic nuclear envelope disassembly (GO:0007077)3.70076569
28CENP-A containing nucleosome assembly (GO:0034080)3.69611161
29DNA replication-dependent nucleosome organization (GO:0034723)3.67880906
30DNA replication-dependent nucleosome assembly (GO:0006335)3.67880906
31nuclear pore organization (GO:0006999)3.65804811
32transcription from mitochondrial promoter (GO:0006390)3.59231945
33ribosomal small subunit assembly (GO:0000028)3.58681772
34nuclear pore complex assembly (GO:0051292)3.58465464
35cullin deneddylation (GO:0010388)3.57490736
36mitochondrial RNA metabolic process (GO:0000959)3.50342624
37nuclear envelope disassembly (GO:0051081)3.47907235
38membrane disassembly (GO:0030397)3.47907235
39protein localization to chromosome, centromeric region (GO:0071459)3.42841519
40maturation of SSU-rRNA (GO:0030490)3.41999271
41transcription elongation from RNA polymerase III promoter (GO:0006385)3.41463958
42termination of RNA polymerase III transcription (GO:0006386)3.41463958
43nucleotide-excision repair, DNA gap filling (GO:0006297)3.41163632
44establishment of chromosome localization (GO:0051303)3.40550864
45regulation of glucokinase activity (GO:0033131)3.40242018
46regulation of hexokinase activity (GO:1903299)3.40242018
47pseudouridine synthesis (GO:0001522)3.39735160
48amino acid salvage (GO:0043102)3.38779014
49L-methionine salvage (GO:0071267)3.38779014
50L-methionine biosynthetic process (GO:0071265)3.38779014
51DNA catabolic process, exonucleolytic (GO:0000738)3.38388801
52double-strand break repair via nonhomologous end joining (GO:0006303)3.37065465
53non-recombinational repair (GO:0000726)3.37065465
54mitotic chromosome condensation (GO:0007076)3.34805752
55maturation of 5.8S rRNA (GO:0000460)3.34624807
56cytochrome complex assembly (GO:0017004)3.33450904
57DNA replication-independent nucleosome organization (GO:0034724)3.32580184
58DNA replication-independent nucleosome assembly (GO:0006336)3.32580184
59folic acid metabolic process (GO:0046655)3.30953688
60rRNA methylation (GO:0031167)3.30199511
61attachment of spindle microtubules to kinetochore (GO:0008608)3.29579130
62ribonucleoprotein complex biogenesis (GO:0022613)3.25353506
63cell cycle G1/S phase transition (GO:0044843)3.23148656
64G1/S transition of mitotic cell cycle (GO:0000082)3.23148656
65protein K6-linked ubiquitination (GO:0085020)3.22437532
66rRNA modification (GO:0000154)3.21864186
67regulation of double-strand break repair via homologous recombination (GO:0010569)3.21207262
68kinetochore organization (GO:0051383)3.19617543
69methionine biosynthetic process (GO:0009086)3.17624635
70rRNA processing (GO:0006364)3.17171184
71maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.16445266
72histone exchange (GO:0043486)3.14143456
73positive regulation of mitochondrial fission (GO:0090141)3.12253064
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.11354329
75regulation of centriole replication (GO:0046599)3.11144320
76kinetochore assembly (GO:0051382)3.11065190
77spliceosomal snRNP assembly (GO:0000387)3.10872769
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.09802167
79transcription-coupled nucleotide-excision repair (GO:0006283)3.09147556
80regulation of nuclear cell cycle DNA replication (GO:0033262)3.08901498
81mitotic sister chromatid segregation (GO:0000070)3.07443717
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06877996
83rRNA metabolic process (GO:0016072)3.06500699
84regulation of cellular amino acid metabolic process (GO:0006521)3.06416332
85water-soluble vitamin biosynthetic process (GO:0042364)3.06066897
86DNA ligation (GO:0006266)3.05866853
87replication fork processing (GO:0031297)3.04929694
88negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04596888
89GMP metabolic process (GO:0046037)3.04214127
90regulation of spindle organization (GO:0090224)3.01669038
91somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01061708
92somatic hypermutation of immunoglobulin genes (GO:0016446)3.01061708
93telomere organization (GO:0032200)3.00796839
94telomere maintenance (GO:0000723)3.00705103
95pteridine-containing compound biosynthetic process (GO:0042559)2.99681336
96mismatch repair (GO:0006298)2.99580717
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97169599
98pore complex assembly (GO:0046931)2.96321999
99DNA duplex unwinding (GO:0032508)2.96041011
100DNA geometric change (GO:0032392)2.95534965
101positive regulation of ligase activity (GO:0051351)2.95494707
102positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.95172611
103signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.93264711
104signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.93264711
105signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.93264711
106RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.92675698
107regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.92614529
108nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91554785
109deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.89817787
110DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.88675947
111aspartate family amino acid biosynthetic process (GO:0009067)2.88542621
112ribosomal large subunit biogenesis (GO:0042273)2.88096981
113regulation of centrosome cycle (GO:0046605)2.86939590
114protein complex biogenesis (GO:0070271)2.86595964
115mitotic sister chromatid cohesion (GO:0007064)2.86278690
116intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.86250745
117signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.86250745
118establishment of protein localization to mitochondrial membrane (GO:0090151)2.85772983
119negative regulation of DNA-dependent DNA replication (GO:2000104)2.85551486
120methionine metabolic process (GO:0006555)2.84863604
121negative regulation of chromosome segregation (GO:0051985)2.83859646
122negative regulation of mitotic sister chromatid separation (GO:2000816)2.83045340
123negative regulation of mitotic sister chromatid segregation (GO:0033048)2.83045340
124negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.83045340
125negative regulation of sister chromatid segregation (GO:0033046)2.83045340
126signal transduction involved in cell cycle checkpoint (GO:0072395)2.82193571
127histone H2A acetylation (GO:0043968)2.81618227
128regulation of mitotic spindle checkpoint (GO:1903504)2.81527347
129regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.81527347
130organelle disassembly (GO:1903008)2.80764075
131mitochondrial respiratory chain complex assembly (GO:0033108)2.80739853
132signal transduction involved in DNA integrity checkpoint (GO:0072401)2.80025408
133signal transduction involved in DNA damage checkpoint (GO:0072422)2.80025408
134protein deneddylation (GO:0000338)2.79817134
135tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79241042
136RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79241042
137spindle checkpoint (GO:0031577)2.79150059
138negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.78886533
139regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.77758308
140proteasome assembly (GO:0043248)2.76938093
141negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.76758321
142negative regulation of ligase activity (GO:0051352)2.76758321
143regulation of ubiquitin-protein transferase activity (GO:0051438)2.76204525
144L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.74874023
145regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.74776057
146pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.74443157
147spindle assembly checkpoint (GO:0071173)2.74068004
148mitotic spindle assembly checkpoint (GO:0007094)2.74042128
149postreplication repair (GO:0006301)2.73632771
150regulation of helicase activity (GO:0051095)2.72802197
151sister chromatid segregation (GO:0000819)2.72660991
152DNA replication (GO:0006260)2.72143544
153somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.71713858
154somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.71713858
155isotype switching (GO:0045190)2.71713858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.57488747
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.20170386
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.58260001
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.55585274
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.49373894
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.21518585
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.99311224
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94204840
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.88630371
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.83153048
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82004582
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78658645
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.77069680
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.74420278
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.73362550
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.38951810
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34409694
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32546340
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32164384
20AR_21909140_ChIP-Seq_LNCAP_Human2.24707856
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21480358
22VDR_23849224_ChIP-Seq_CD4+_Human2.20163287
23XRN2_22483619_ChIP-Seq_HELA_Human2.12732763
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.06338124
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03871859
26FOXP3_21729870_ChIP-Seq_TREG_Human2.02104290
27ZNF274_21170338_ChIP-Seq_K562_Hela2.01700247
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00229631
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96009469
30GABP_19822575_ChIP-Seq_HepG2_Human1.94022911
31DCP1A_22483619_ChIP-Seq_HELA_Human1.92879610
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90640785
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86458110
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86099009
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.85839991
36* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84651236
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83850086
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82191514
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80240974
40EWS_26573619_Chip-Seq_HEK293_Human1.79672716
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77930477
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77429504
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72059699
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71217746
45TTF2_22483619_ChIP-Seq_HELA_Human1.70112123
46* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69863490
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63497050
48FUS_26573619_Chip-Seq_HEK293_Human1.60885471
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60633288
50IGF1R_20145208_ChIP-Seq_DFB_Human1.59330661
51ELK1_19687146_ChIP-ChIP_HELA_Human1.58996525
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57575875
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56948863
54CIITA_25753668_ChIP-Seq_RAJI_Human1.56131047
55MYC_22102868_ChIP-Seq_BL_Human1.55671741
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52286122
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.51957231
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50750444
59KDM5A_27292631_Chip-Seq_BREAST_Human1.50173438
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.48586655
61* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43266334
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40676050
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40285673
64IRF1_19129219_ChIP-ChIP_H3396_Human1.38148947
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36794560
66* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36471532
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35115452
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31432190
69VDR_22108803_ChIP-Seq_LS180_Human1.31089976
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.29868916
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28775513
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27710222
73TFEB_21752829_ChIP-Seq_HELA_Human1.27558410
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27291294
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23413069
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22385729
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22018947
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21089447
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.20017250
80TAF15_26573619_Chip-Seq_HEK293_Human1.19336183
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18978818
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18147758
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16786088
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.16467647
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16410032
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16283497
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15849007
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08192872
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07435157
90* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07085854
91P300_19829295_ChIP-Seq_ESCs_Human1.05824853
92SPI1_23547873_ChIP-Seq_NB4_Human1.05021676
93HTT_18923047_ChIP-ChIP_STHdh_Human1.02379050
94MYC_18940864_ChIP-ChIP_HL60_Human1.01102804
95* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00998625
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97390457
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96981549
98RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96594463
99ER_23166858_ChIP-Seq_MCF-7_Human0.95419571
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93406443
101NANOG_16153702_ChIP-ChIP_HESCs_Human0.92465391
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92332004
103POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91911441
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90928666
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90841883
106EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89862305
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89666387
108SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88704451
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87330656
110SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.87093153
111IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.86506117
112TP53_22573176_ChIP-Seq_HFKS_Human0.86297017
113ELK1_22589737_ChIP-Seq_MCF10A_Human0.84495120
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84291651
115CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83224374
116EZH2_27294783_Chip-Seq_NPCs_Mouse0.80793523
117MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80743496
118CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80523545
119PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80152364
120GBX2_23144817_ChIP-Seq_PC3_Human0.80136018
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79674913
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.78527041
123SOX2_19829295_ChIP-Seq_ESCs_Human0.78322328
124NANOG_19829295_ChIP-Seq_ESCs_Human0.78322328
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.77945243
126* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77689162
127CTBP2_25329375_ChIP-Seq_LNCAP_Human0.77648647
128KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.77410310
129FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76088428
130KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74837386
131HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.73692305
132VDR_21846776_ChIP-Seq_THP-1_Human0.73299281
133STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.73018076
134SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.72625379
135RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.72219943
136TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.71570193
137ESR1_15608294_ChIP-ChIP_MCF-7_Human0.71189395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.49860007
2MP0010094_abnormal_chromosome_stability5.05603110
3MP0004957_abnormal_blastocyst_morpholog4.63364594
4MP0008057_abnormal_DNA_replication4.55208104
5MP0003111_abnormal_nucleus_morphology4.53957245
6MP0003077_abnormal_cell_cycle3.94459202
7MP0008058_abnormal_DNA_repair3.37829389
8MP0003195_calcinosis2.94595710
9MP0008877_abnormal_DNA_methylation2.90255256
10MP0002396_abnormal_hematopoietic_system2.83322122
11MP0008007_abnormal_cellular_replicative2.75571040
12MP0009379_abnormal_foot_pigmentation2.72327338
13MP0003123_paternal_imprinting2.64263443
14MP0008932_abnormal_embryonic_tissue2.49734898
15MP0010352_gastrointestinal_tract_polyps2.41655202
16MP0001730_embryonic_growth_arrest2.37269199
17MP0000350_abnormal_cell_proliferation2.23198801
18MP0000372_irregular_coat_pigmentation2.15410919
19MP0002837_dystrophic_cardiac_calcinosis2.09703804
20MP0003786_premature_aging1.97584076
21MP0008995_early_reproductive_senescence1.94254122
22MP0006072_abnormal_retinal_apoptosis1.91773582
23MP0010307_abnormal_tumor_latency1.82246213
24MP0003718_maternal_effect1.78642556
25MP0005379_endocrine/exocrine_gland_phen1.77945176
26MP0002102_abnormal_ear_morphology1.77825995
27MP0005646_abnormal_pituitary_gland1.74891818
28MP0003880_abnormal_central_pattern1.74135245
29MP0001697_abnormal_embryo_size1.71423143
30MP0002938_white_spotting1.70788929
31MP0003763_abnormal_thymus_physiology1.70656762
32MP0004147_increased_porphyrin_level1.69934145
33MP0000490_abnormal_crypts_of1.69737794
34MP0003787_abnormal_imprinting1.65179945
35MP0002019_abnormal_tumor_incidence1.64139559
36MP0004808_abnormal_hematopoietic_stem1.60659692
37MP0000313_abnormal_cell_death1.59603221
38MP0001672_abnormal_embryogenesis/_devel1.58906564
39MP0005380_embryogenesis_phenotype1.58906564
40MP0005174_abnormal_tail_pigmentation1.52747110
41MP0009333_abnormal_splenocyte_physiolog1.52338934
42MP0002080_prenatal_lethality1.50996064
43MP0005645_abnormal_hypothalamus_physiol1.46744210
44MP0002163_abnormal_gland_morphology1.45606420
45MP0003984_embryonic_growth_retardation1.45444779
46MP0006054_spinal_hemorrhage1.43718830
47MP0003806_abnormal_nucleotide_metabolis1.43676777
48MP0002088_abnormal_embryonic_growth/wei1.40591117
49MP0005397_hematopoietic_system_phenotyp1.34442558
50MP0001545_abnormal_hematopoietic_system1.34442558
51MP0002398_abnormal_bone_marrow1.32108098
52MP0000689_abnormal_spleen_morphology1.31869786
53MP0001188_hyperpigmentation1.31520885
54MP0006035_abnormal_mitochondrial_morpho1.30676074
55MP0002210_abnormal_sex_determination1.29333831
56MP0003121_genomic_imprinting1.29116312
57MP0000015_abnormal_ear_pigmentation1.28928882
58MP0002086_abnormal_extraembryonic_tissu1.27892098
59MP0002085_abnormal_embryonic_tissue1.27522730
60MP0002722_abnormal_immune_system1.26725232
61MP0002160_abnormal_reproductive_system1.25764647
62MP0008789_abnormal_olfactory_epithelium1.25609195
63MP0005253_abnormal_eye_physiology1.24826802
64MP0001984_abnormal_olfaction1.24649163
65MP0005551_abnormal_eye_electrophysiolog1.21627633
66MP0000703_abnormal_thymus_morphology1.20792899
67MP0005220_abnormal_exocrine_pancreas1.20161210
68MP0005332_abnormal_amino_acid1.19514239
69MP0003186_abnormal_redox_activity1.16680548
70MP0000427_abnormal_hair_cycle1.15287066
71MP0002084_abnormal_developmental_patter1.13056199
72MP0004197_abnormal_fetal_growth/weight/1.12584366
73MP0000516_abnormal_urinary_system1.11713146
74MP0005367_renal/urinary_system_phenotyp1.11713146
75MP0000358_abnormal_cell_content/1.10709403
76MP0004215_abnormal_myocardial_fiber1.10558465
77MP0001929_abnormal_gametogenesis1.09167323
78MP0004133_heterotaxia1.08834282
79MP0000858_altered_metastatic_potential1.06842645
80MP0001145_abnormal_male_reproductive1.05955721
81MP0001119_abnormal_female_reproductive1.05932189
82MP0005076_abnormal_cell_differentiation1.05515850
83MP0003567_abnormal_fetal_cardiomyocyte1.04471173
84MP0005409_darkened_coat_color1.03609669
85MP0008875_abnormal_xenobiotic_pharmacok1.03471506
86MP0001661_extended_life_span1.03142292
87MP0005408_hypopigmentation1.03064477
88MP0001485_abnormal_pinna_reflex1.02723667
89MP0006036_abnormal_mitochondrial_physio1.00616727
90MP0005671_abnormal_response_to1.00351763
91MP0002429_abnormal_blood_cell0.99270900
92MP0005395_other_phenotype0.98227918
93MP0000653_abnormal_sex_gland0.97686556
94MP0003941_abnormal_skin_development0.97479364
95MP0005389_reproductive_system_phenotype0.97120010
96MP0002139_abnormal_hepatobiliary_system0.95978541
97MP0001853_heart_inflammation0.94814228
98MP0001919_abnormal_reproductive_system0.94482893
99MP0009697_abnormal_copulation0.94206234
100MP0000716_abnormal_immune_system0.91927581
101MP0002090_abnormal_vision0.90960786
102MP0003698_abnormal_male_reproductive0.88893447
103MP0002254_reproductive_system_inflammat0.88828562
104MP0005084_abnormal_gallbladder_morpholo0.88262111
105MP0005384_cellular_phenotype0.86488171
106MP0008872_abnormal_physiological_respon0.85734044
107MP0001986_abnormal_taste_sensitivity0.83558963
108MP0001800_abnormal_humoral_immune0.83265559
109MP0005621_abnormal_cell_physiology0.79905322
110MP0001293_anophthalmia0.78708997
111MP0001835_abnormal_antigen_presentation0.78649800
112MP0001764_abnormal_homeostasis0.78274189
113MP0002420_abnormal_adaptive_immunity0.78177961
114MP0002006_tumorigenesis0.77892228
115MP0002751_abnormal_autonomic_nervous0.77546064
116MP0003315_abnormal_perineum_morphology0.77280659
117MP0009046_muscle_twitch0.76752590
118MP0001819_abnormal_immune_cell0.76615230
119MP0001905_abnormal_dopamine_level0.75230169
120MP0000647_abnormal_sebaceous_gland0.74181054
121MP0005023_abnormal_wound_healing0.73783117
122MP0006292_abnormal_olfactory_placode0.73731899
123MP0002095_abnormal_skin_pigmentation0.73118652
124MP0002876_abnormal_thyroid_physiology0.73043647
125MP0003890_abnormal_embryonic-extraembry0.72369370
126MP0002452_abnormal_antigen_presenting0.70480479
127MP0005376_homeostasis/metabolism_phenot0.70360132
128MP0003937_abnormal_limbs/digits/tail_de0.69417997
129MP0003221_abnormal_cardiomyocyte_apopto0.69406793
130MP0009672_abnormal_birth_weight0.68766578
131MP0002723_abnormal_immune_serum0.68033049
132MP0001324_abnormal_eye_pigmentation0.67395959
133MP0002736_abnormal_nociception_after0.67113178
134MP0005647_abnormal_sex_gland0.66835788
135MP0005075_abnormal_melanosome_morpholog0.66800992
136MP0008260_abnormal_autophagy0.66436038
137MP0003448_altered_tumor_morphology0.65120212
138MP0003943_abnormal_hepatobiliary_system0.64815069
139MP0005636_abnormal_mineral_homeostasis0.64477978
140MP0010234_abnormal_vibrissa_follicle0.64412801
141MP0002234_abnormal_pharynx_morphology0.64324740
142MP0002405_respiratory_system_inflammati0.63759002
143MP0003699_abnormal_female_reproductive0.63410691
144MP0008775_abnormal_heart_ventricle0.62916222
145MP0003646_muscle_fatigue0.62837030
146MP0000477_abnormal_intestine_morphology0.62834755
147MP0000678_abnormal_parathyroid_gland0.62325076
148MP0003656_abnormal_erythrocyte_physiolo0.61258972
149MP0001915_intracranial_hemorrhage0.60949742
150MP0001529_abnormal_vocalization0.60195674
151MP0004264_abnormal_extraembryonic_tissu0.58057725
152MP0002075_abnormal_coat/hair_pigmentati0.56783552
153MP0005451_abnormal_body_composition0.56670404
154MP0005266_abnormal_metabolism0.56508576
155MP0000598_abnormal_liver_morphology0.55346243

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.55462163
2Oral leukoplakia (HP:0002745)3.83637447
311 pairs of ribs (HP:0000878)3.78942317
4Abnormality of chromosome stability (HP:0003220)3.62796656
5Abnormality of the preputium (HP:0100587)3.57709477
6Degeneration of anterior horn cells (HP:0002398)3.52743875
7Abnormality of the anterior horn cell (HP:0006802)3.52743875
8Agnosia (HP:0010524)3.50560663
9Meckel diverticulum (HP:0002245)3.45726029
10Aplastic anemia (HP:0001915)3.43616973
11Breast hypoplasia (HP:0003187)3.37015633
12Colon cancer (HP:0003003)3.30159481
13Aplasia/Hypoplasia of the uvula (HP:0010293)3.29807517
14Abnormality of the ileum (HP:0001549)3.24703044
15Chromsome breakage (HP:0040012)3.24441747
16Acute necrotizing encephalopathy (HP:0006965)3.23695461
17Increased CSF lactate (HP:0002490)3.23020725
18Reticulocytopenia (HP:0001896)3.10651089
19Rough bone trabeculation (HP:0100670)3.09238799
20Patellar aplasia (HP:0006443)3.08164854
21Abnormality of methionine metabolism (HP:0010901)3.08051908
22Abnormal mitochondria in muscle tissue (HP:0008316)3.05499637
23Progressive macrocephaly (HP:0004481)3.03815126
24Methylmalonic acidemia (HP:0002912)3.00436741
25Acute encephalopathy (HP:0006846)2.98176470
26Myelodysplasia (HP:0002863)2.97797588
27Abnormal number of erythroid precursors (HP:0012131)2.95800567
28Increased hepatocellular lipid droplets (HP:0006565)2.94105278
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93676033
30Absent thumb (HP:0009777)2.92376040
31Abnormality of cells of the erythroid lineage (HP:0012130)2.91853881
32Increased serum pyruvate (HP:0003542)2.91815771
33Abnormality of glycolysis (HP:0004366)2.91208575
34Medulloblastoma (HP:0002885)2.90517734
35Mitochondrial inheritance (HP:0001427)2.87249059
36Lipid accumulation in hepatocytes (HP:0006561)2.84305230
37Aplasia/Hypoplasia of the patella (HP:0006498)2.80141350
38Thrombocytosis (HP:0001894)2.77841065
39Bone marrow hypocellularity (HP:0005528)2.73955586
40Abnormality of aspartate family amino acid metabolism (HP:0010899)2.73670100
41Carpal bone hypoplasia (HP:0001498)2.72344325
42Cerebral hypomyelination (HP:0006808)2.72217937
43Small intestinal stenosis (HP:0012848)2.71637436
44Duodenal stenosis (HP:0100867)2.71637436
45Cerebral edema (HP:0002181)2.71358667
46Abnormality of serum amino acid levels (HP:0003112)2.71287564
47Hepatic necrosis (HP:0002605)2.69595667
48Metaphyseal cupping (HP:0003021)2.69066605
49Microretrognathia (HP:0000308)2.68784563
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.67513555
51Abnormality of alanine metabolism (HP:0010916)2.67513555
52Hyperalaninemia (HP:0003348)2.67513555
53Abnormality of vitamin B metabolism (HP:0004340)2.58125542
54Type I transferrin isoform profile (HP:0003642)2.55003791
55Hyperglycinemia (HP:0002154)2.52923612
56Missing ribs (HP:0000921)2.50611394
57Abnormality of the fovea (HP:0000493)2.48370871
58Sloping forehead (HP:0000340)2.47493199
59Hypoplasia of the fovea (HP:0007750)2.47453239
60Aplasia/Hypoplasia of the fovea (HP:0008060)2.47453239
61Multiple enchondromatosis (HP:0005701)2.46167171
62Selective tooth agenesis (HP:0001592)2.43217383
63Abnormality of the labia minora (HP:0012880)2.39721527
64Medial flaring of the eyebrow (HP:0010747)2.39515624
65Impulsivity (HP:0100710)2.38855448
66Abnormality of the vitamin B12 metabolism (HP:0004341)2.37380842
67Rhabdomyosarcoma (HP:0002859)2.36883038
68Methylmalonic aciduria (HP:0012120)2.34785551
69Premature graying of hair (HP:0002216)2.34774401
70Neoplasm of the adrenal gland (HP:0100631)2.34712045
71Cellular immunodeficiency (HP:0005374)2.33207289
72Exertional dyspnea (HP:0002875)2.30653896
73Abnormality of the calcaneus (HP:0008364)2.28453627
74IgM deficiency (HP:0002850)2.28183916
75Megaloblastic anemia (HP:0001889)2.27788263
76Poor head control (HP:0002421)2.27299662
77Clubbing of toes (HP:0100760)2.26611850
78Atrophy/Degeneration involving motor neurons (HP:0007373)2.26435404
79Abnormality of the carotid arteries (HP:0005344)2.24361613
80Abnormality of the duodenum (HP:0002246)2.24332271
81Tubulointerstitial nephritis (HP:0001970)2.23814088
82Irregular epiphyses (HP:0010582)2.23600729
83Microvesicular hepatic steatosis (HP:0001414)2.23146385
84Lactic acidosis (HP:0003128)2.21898972
85Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.20741080
86Decreased activity of mitochondrial respiratory chain (HP:0008972)2.20741080
87Self-mutilation (HP:0000742)2.20171121
88Lethargy (HP:0001254)2.20043478
89Pancreatic fibrosis (HP:0100732)2.19998497
90Ependymoma (HP:0002888)2.18419692
91Abnormal trabecular bone morphology (HP:0100671)2.16340858
92Horseshoe kidney (HP:0000085)2.15795885
93Abnormality of pyrimidine metabolism (HP:0004353)2.14974387
94Tracheoesophageal fistula (HP:0002575)2.14253094
95Volvulus (HP:0002580)2.13363516
96Facial hemangioma (HP:0000329)2.12171615
97Breast carcinoma (HP:0003002)2.10518193
98Macrocytic anemia (HP:0001972)2.10318942
99Secondary amenorrhea (HP:0000869)2.10286611
100Neoplasm of the pancreas (HP:0002894)2.08739693
101Type 2 muscle fiber atrophy (HP:0003554)2.06196554
102CNS hypomyelination (HP:0003429)2.05894494
103Muscle fiber atrophy (HP:0100295)2.05428557
104Pancreatic cysts (HP:0001737)2.04726120
105Hypoglycemic coma (HP:0001325)2.01792378
106Premature ovarian failure (HP:0008209)2.01483030
107Lymphoma (HP:0002665)2.01131716
108Ectopic kidney (HP:0000086)2.01113807
109Abnormality of homocysteine metabolism (HP:0010919)2.00567062
110Homocystinuria (HP:0002156)2.00567062
111Glioma (HP:0009733)2.00380381
112Hypoplasia of the radius (HP:0002984)2.00171620
113Short tibia (HP:0005736)2.00136277
114Hypoplasia of the capital femoral epiphysis (HP:0003090)1.99718806
115Trismus (HP:0000211)1.99419066
116CNS demyelination (HP:0007305)1.97883564
117Pancreatic islet-cell hyperplasia (HP:0004510)1.96904312
118Cleft eyelid (HP:0000625)1.96412973
119Nephronophthisis (HP:0000090)1.95608118
120Renal Fanconi syndrome (HP:0001994)1.95598760
121Aplasia/Hypoplasia of the tibia (HP:0005772)1.95459788
122Stenosis of the external auditory canal (HP:0000402)1.94680909
123Nephrogenic diabetes insipidus (HP:0009806)1.94679101
124Cafe-au-lait spot (HP:0000957)1.92595053
125Respiratory failure (HP:0002878)1.92564695
126Abnormality of aromatic amino acid family metabolism (HP:0004338)1.92183639
127Increased serum lactate (HP:0002151)1.91005247
128Triphalangeal thumb (HP:0001199)1.90502773
129Congenital primary aphakia (HP:0007707)1.90117497
130Renal cortical cysts (HP:0000803)1.89748806
131Abnormal spermatogenesis (HP:0008669)1.89032385
132Glossoptosis (HP:0000162)1.88379730
133Atresia of the external auditory canal (HP:0000413)1.88370687
134Slender long bone (HP:0003100)1.87733630
135Nephroblastoma (Wilms tumor) (HP:0002667)1.87461602
136Amaurosis fugax (HP:0100576)1.86942991
137Pallor (HP:0000980)1.86666025
138Pulmonary fibrosis (HP:0002206)1.83936668
139Neoplasm of the colon (HP:0100273)1.83483584
140Pancytopenia (HP:0001876)1.83180904
141Abnormality of sulfur amino acid metabolism (HP:0004339)1.82938488
142Respiratory difficulties (HP:0002880)1.82406695
143Molar tooth sign on MRI (HP:0002419)1.81521967
144Abnormality of midbrain morphology (HP:0002418)1.81521967
145True hermaphroditism (HP:0010459)1.80848331
146Neuroendocrine neoplasm (HP:0100634)1.80088967
147Short thumb (HP:0009778)1.79971157
148Abnormal lung lobation (HP:0002101)1.79956872
149Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79151791
150Abnormal protein N-linked glycosylation (HP:0012347)1.79151791
151Abnormal protein glycosylation (HP:0012346)1.79151791
152Abnormal glycosylation (HP:0012345)1.79151791
153Tongue fasciculations (HP:0001308)1.78466689
154Reduced antithrombin III activity (HP:0001976)1.78142495
155Cutaneous melanoma (HP:0012056)1.76499741
156Gait imbalance (HP:0002141)1.76129104
157Ovarian neoplasm (HP:0100615)1.75642325
158Hepatocellular necrosis (HP:0001404)1.75167615
159B lymphocytopenia (HP:0010976)1.74403645
160Embryonal renal neoplasm (HP:0011794)1.74375144
161Prominent metopic ridge (HP:0005487)1.74301303
1623-Methylglutaconic aciduria (HP:0003535)1.74155427
163Abnormality of T cells (HP:0002843)1.74139168
164Hyperinsulinemic hypoglycemia (HP:0000825)1.71658622
165Abnormality of the astrocytes (HP:0100707)1.70257193
166Astrocytoma (HP:0009592)1.70257193
167Abnormality of vitamin metabolism (HP:0100508)1.69628120
168Pheochromocytoma (HP:0002666)1.67480167

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.58561866
2WEE14.36398222
3BUB14.22687054
4MST43.75494803
5TRIM283.53781058
6FRK3.53642531
7MAP4K23.43032431
8EIF2AK13.07754406
9ACVR1B2.97610191
10BRSK22.93266023
11NME22.77309680
12NEK22.64512136
13TSSK62.56554295
14EIF2AK32.29077637
15PLK42.27323025
16PINK12.26522684
17SRPK12.24562748
18PDK22.21533058
19CCNB12.09094432
20PBK2.06572203
21NEK12.04376396
22TESK22.04344330
23PLK11.98525278
24TTK1.96618997
25NUAK11.93384475
26BCR1.91938649
27STK161.91014091
28SIK31.82505386
29ERBB31.72130453
30PASK1.66952365
31ATR1.62141880
32BRSK11.61242699
33RPS6KA41.54796554
34PKN21.53594807
35AURKB1.49814421
36VRK11.48893718
37PLK31.46887660
38CDK71.46417018
39WNK31.45313794
40CDK41.39938364
41VRK21.36889390
42MKNK11.31288842
43BMPR1B1.31160520
44GRK11.30700527
45CHEK21.29488335
46BCKDK1.20634398
47AURKA1.17076940
48RPS6KB21.14601369
49BRAF1.13228751
50TGFBR11.12088781
51MKNK21.11944777
52PIM21.11173795
53CHEK11.06227039
54MAP3K81.04879786
55FLT31.02239122
56EPHA21.00466685
57ADRBK21.00353397
58TLK10.98460068
59STK100.97707266
60SCYL20.96189473
61CDK80.92134829
62MAP4K10.91994258
63PAK40.91304109
64DYRK30.89538620
65PLK20.84394072
66KDR0.83389329
67EEF2K0.81483793
68EPHA30.80844969
69OXSR10.80731972
70MUSK0.80320004
71MAP3K40.78865798
72CDK20.78251291
73PIM10.77443763
74STK390.74786659
75STK40.72681465
76STK30.72244611
77TESK10.70782769
78ATM0.70772525
79CSNK1G20.70737457
80NEK90.69795950
81FER0.67280657
82ZAP700.65800986
83TEC0.64980897
84PDK30.64428933
85PDK40.64428933
86TXK0.64148903
87CSNK2A20.63878475
88IRAK30.63545558
89STK38L0.62467660
90CSNK2A10.62051774
91FGFR20.60734056
92DAPK10.60060096
93ZAK0.59895186
94MAPK130.59311940
95CDK30.58616583
96MAP2K30.56642860
97LATS20.53889968
98CSNK1G30.53289575
99ARAF0.53232579
100CDK120.52559505
101PRKCI0.51862088
102IRAK40.51627759
103MAP3K110.51444731
104CDK10.50246434
105ALK0.50066516
106CDK90.50003515
107NEK60.49736559
108MARK30.48242935
109PRKCE0.47662970
110MINK10.47296978
111CDK60.46680476
112MELK0.46380529
113STK240.45237386
114EIF2AK20.44863900
115MAP2K70.42431946
116PAK10.41340019
117JAK30.40188901
118LATS10.39519419
119CSNK1G10.39070740
120PAK30.38564536
121DYRK20.37758793
122ABL20.37618007
123RAF10.35273284
124MAP3K30.34758808
125NLK0.34697290
126CSNK1A10.34670957
127RPS6KA50.31672666
128CSNK1A1L0.31259851
129NTRK30.31208304
130BRD40.31054584
131LRRK20.30189595
132NME10.30163869
133MST1R0.28920308
134TYK20.28441769
135MAP3K120.27193082
136KIT0.27183579
137BTK0.26472019
138MAPKAPK30.25799588
139MAP3K50.25512303
140CAMK2D0.24301363
141TNIK0.23446955
142PRKACB0.23327499
143RPS6KB10.22724768
144ERBB40.21750718

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.27453448
2Mismatch repair_Homo sapiens_hsa034304.47994574
3RNA polymerase_Homo sapiens_hsa030203.71348882
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.62428792
5Homologous recombination_Homo sapiens_hsa034403.49833775
6Proteasome_Homo sapiens_hsa030503.46095016
7RNA transport_Homo sapiens_hsa030132.94563343
8Base excision repair_Homo sapiens_hsa034102.92423289
9Cell cycle_Homo sapiens_hsa041102.82213887
10Spliceosome_Homo sapiens_hsa030402.80440231
11Pyrimidine metabolism_Homo sapiens_hsa002402.78317497
12Nucleotide excision repair_Homo sapiens_hsa034202.77672305
13Ribosome_Homo sapiens_hsa030102.73275101
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.61835754
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.55158409
16One carbon pool by folate_Homo sapiens_hsa006702.53303959
17Fanconi anemia pathway_Homo sapiens_hsa034602.27762375
18RNA degradation_Homo sapiens_hsa030182.05296083
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.02775244
20Propanoate metabolism_Homo sapiens_hsa006401.93109581
21Basal transcription factors_Homo sapiens_hsa030221.80722247
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76301770
23Non-homologous end-joining_Homo sapiens_hsa034501.67738389
24Fatty acid elongation_Homo sapiens_hsa000621.64767327
25p53 signaling pathway_Homo sapiens_hsa041151.52767345
26Butanoate metabolism_Homo sapiens_hsa006501.52635820
27Purine metabolism_Homo sapiens_hsa002301.49192190
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.48378110
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43844114
30mRNA surveillance pathway_Homo sapiens_hsa030151.30604533
31Folate biosynthesis_Homo sapiens_hsa007901.30586951
32Epstein-Barr virus infection_Homo sapiens_hsa051691.26529498
33Biosynthesis of amino acids_Homo sapiens_hsa012301.19795165
34Pentose phosphate pathway_Homo sapiens_hsa000301.19242660
35Phototransduction_Homo sapiens_hsa047441.14811794
36Sulfur metabolism_Homo sapiens_hsa009201.11566637
37Protein export_Homo sapiens_hsa030601.05868795
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05072271
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.02795252
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02208267
41Caffeine metabolism_Homo sapiens_hsa002320.94488269
42Antigen processing and presentation_Homo sapiens_hsa046120.92681141
43Steroid biosynthesis_Homo sapiens_hsa001000.92616240
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.89425160
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85431907
46Herpes simplex infection_Homo sapiens_hsa051680.84867075
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81141530
48Viral carcinogenesis_Homo sapiens_hsa052030.79901958
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.78883264
50Oocyte meiosis_Homo sapiens_hsa041140.78224543
51Alzheimers disease_Homo sapiens_hsa050100.77653283
52Selenocompound metabolism_Homo sapiens_hsa004500.77572254
53Collecting duct acid secretion_Homo sapiens_hsa049660.77451209
54Vitamin B6 metabolism_Homo sapiens_hsa007500.77029297
55N-Glycan biosynthesis_Homo sapiens_hsa005100.76249779
56Carbon metabolism_Homo sapiens_hsa012000.75798245
57Fatty acid metabolism_Homo sapiens_hsa012120.74594808
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71868079
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70939508
60Thyroid cancer_Homo sapiens_hsa052160.70378286
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68897529
62Sulfur relay system_Homo sapiens_hsa041220.67107573
63Systemic lupus erythematosus_Homo sapiens_hsa053220.64826507
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64338562
65HTLV-I infection_Homo sapiens_hsa051660.62116820
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61201751
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59667722
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.57976146
69Tryptophan metabolism_Homo sapiens_hsa003800.56045392
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54426466
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54360905
72Primary immunodeficiency_Homo sapiens_hsa053400.53080903
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50888052
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50760614
75Arginine biosynthesis_Homo sapiens_hsa002200.50467196
76Huntingtons disease_Homo sapiens_hsa050160.50046041
77beta-Alanine metabolism_Homo sapiens_hsa004100.49984890
78Legionellosis_Homo sapiens_hsa051340.48658545
79Chemical carcinogenesis_Homo sapiens_hsa052040.48615516
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47878345
81Measles_Homo sapiens_hsa051620.47434588
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47310559
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.47199914
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45903200
85Vitamin digestion and absorption_Homo sapiens_hsa049770.45277872
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45270906
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44137881
88Fructose and mannose metabolism_Homo sapiens_hsa000510.44121392
89Retinol metabolism_Homo sapiens_hsa008300.44118200
90Other glycan degradation_Homo sapiens_hsa005110.43780134
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41837572
92Fatty acid degradation_Homo sapiens_hsa000710.40719975
93Glutathione metabolism_Homo sapiens_hsa004800.40089247
94Parkinsons disease_Homo sapiens_hsa050120.39718574
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39205487
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35245819
97Hepatitis B_Homo sapiens_hsa051610.34453537
98Apoptosis_Homo sapiens_hsa042100.33885591
99Colorectal cancer_Homo sapiens_hsa052100.33703926
100Metabolic pathways_Homo sapiens_hsa011000.32781575
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32102579
102Sphingolipid metabolism_Homo sapiens_hsa006000.30460676
103Linoleic acid metabolism_Homo sapiens_hsa005910.30404692
104Vibrio cholerae infection_Homo sapiens_hsa051100.29422876
105Small cell lung cancer_Homo sapiens_hsa052220.28321396
106Type I diabetes mellitus_Homo sapiens_hsa049400.27480853
107Ether lipid metabolism_Homo sapiens_hsa005650.27092206
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.25767405
109Tyrosine metabolism_Homo sapiens_hsa003500.25642123
110MicroRNAs in cancer_Homo sapiens_hsa052060.25337142
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24572763
112Galactose metabolism_Homo sapiens_hsa000520.24487146
113Nitrogen metabolism_Homo sapiens_hsa009100.24186273
114Shigellosis_Homo sapiens_hsa051310.24083078
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22879219
116Influenza A_Homo sapiens_hsa051640.22238157
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21176850
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21138008
119Olfactory transduction_Homo sapiens_hsa047400.20897841
120Hematopoietic cell lineage_Homo sapiens_hsa046400.20789778
121Leishmaniasis_Homo sapiens_hsa051400.20460535
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20075726
123Oxidative phosphorylation_Homo sapiens_hsa001900.18987677
124Arginine and proline metabolism_Homo sapiens_hsa003300.18491375
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18116374
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17662678
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17112593
128Renin-angiotensin system_Homo sapiens_hsa046140.16808443
129Regulation of autophagy_Homo sapiens_hsa041400.16746905
130Pyruvate metabolism_Homo sapiens_hsa006200.15712928
131TGF-beta signaling pathway_Homo sapiens_hsa043500.12458220
132Alcoholism_Homo sapiens_hsa050340.10635694
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10116557
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.09992443
135HIF-1 signaling pathway_Homo sapiens_hsa040660.09121085
136Peroxisome_Homo sapiens_hsa041460.08351573
137Asthma_Homo sapiens_hsa053100.08128174
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07867961
139Jak-STAT signaling pathway_Homo sapiens_hsa046300.07735896
140Allograft rejection_Homo sapiens_hsa053300.06741207
141Acute myeloid leukemia_Homo sapiens_hsa052210.06213232
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.05674681

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